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OTAR3088
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BioData-CellLine_annotated

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PMC9080589
Metastasis remains the most common cause of lethal outcomes in PTC after curative resection.
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PMC11218145
It has been demonstrated that to provoke its pro-apoptotic effects, BAX also modulates the Ca homeostasis, by controlling the Ca transmission between the ER and the mitochondria and by regulating the mitochondrial ψm and the generation of ROS .
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PMC11687167
In recent years, increasing evidence has indicated other important roles for PCSK9 in inflammation, tumors, and even immune regulation.
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PMC11363012
The results from SIRIUS revealed the presence of 122 alkaloids, 66 flavonoids and anthocyanins, and 5 iridoids across all three tissues (Supporting Information Data 2).
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PMC9429973
The cumulative doses of INO given before and after this amendment were 4.3 mg/m and 2.7 mg/m, respectively.
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PMC11422150
It was significantly suppressed compared to the untreated group n = 5 each in untreated SCI and hAMSC groups and n = 4 in the normal group.
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PMC9587866
PASS and gene expression studies revealed some important findings: both compounds are HIF1-alpha (Hypoxia inducible factor alpha) inhibitors.
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PMC7757104
The roles of OPNc in non-small cell lung cancer cells were mediated by Runt-related transcription factor 2 via a histone deacetylase-dependent pathway, further suggesting that OPNc may be a marker of the EMT and tumor progression in lung cancer.
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PMC11461874
We then assessed the temporal profiles of protein expression in the TRAF7-KO liver with mass spectrometry-based proteomic analysis (Supplementary Data 1).
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PMC11732523
January 16, 2024: The scan demonstrates an increased number and extent of patchy and linear opacities in both lungs, with some areas showing heightened density. (
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PMC3164356
However, it is important to note that CHO-K1 is an ancestral cell line from which many CHO cell lines have been derived.
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PMC11790971
Confusion matrices were generated based on cells from monoclonal wells (Fig. 2g, j, m).
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PMC9429973
Therapy was discontinued for disease progression in 47.4% of pts on IXA-POM-DEX and 76.9% of pts on POM-DEX and for adverse events in 7.9% and 7.7% of pts, respectively.
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PMC11545737
It was able to mitigate the depletion of immature transitional B cells and resting memory B cells in peripheral blood mononuclear cells (PBMCs) from septic shock patients .
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PMC11743414
GSEA generated an ordered list based on the correlation between all genes and FHL1 expression, indicating significant differences between high- and low-FHL1 groups , arranged 1000 times for each analysis.
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PMC10421378
Probiotics can interact with immune cells present in the gut-associated lymphoid tissue, promoting beneficial immune responses and potentially regulating excessive inflammation .
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PMC11267830
RNA isolation, library preparation, transcriptomic sequencing (Illumina NovaSeq 6000), and data cleansing were carried out by Novogene Bioinformatics Technology Co., Ltd. (Beijing, China).
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PMC10745221
Extracts loaded on the gel represented approximately 250,000 cells.
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PMC9429973
324 untreated CLLs (54 with IGH deletion (del-3’IGH) and 270 as the control group) were sequenced by targeted-NGS, with a custom panel including 54 CLL-related genes (Nextseq platform, Illumina).
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PMC6379402
Twenty-four hour after transfection, 90 µl of fresh media was added and 72 h after transfection, Presto Blue cell viability assay was performed.
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PMC9784246
A total of 1 μL of each etoposide stock solution (5–0.019 mg/mL, two-fold dilution) was added to the corresponding wells of a 96 microplate, resulting in final serial concentrations of (50, 25, 12.5, 6.25, 3.12, 1.56, 0.78, 0.39, and 0.19 μg/mL).
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PMC11773391
No financial and personal relationships with other people or organisations could inappropriately influence (bias) this work.
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PMC8973085
The most reactive derivative 5d showed H-acceptor interaction toward the 4k9g protein with fit docking paths (bond length ≤3.5 Å) (Figures 6 and 7).
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PMC11565047
Then, media were renewed, and the cells were treated with either vehicle (ethanol 96 %; Sigma), 17β-estradiol (E2; 10 nM; Sigma; agonist of ERα), R1881 (metribolone; 10 nM; Toronto Research Chemicals; agonist of AR) or a combination of both.
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PMC10006224
These opposite effects on the two variants are independent of the presence of the other variant and epistatic to KD of other regulators of cohesin dynamics.
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PMC9966931
We demonstrate, for the first time, their antifungal activity against two of most scientific/economic important phytopathogenic fungi, Colletotrichum gloeosporioides Penz.
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PMC11792888
The maximal effects (Emax) at the highest venom concentration tested (2 mg/mL) reached 52.39 ± 5.91% and 53.86 ± 7.52% cell viability for non-cancerous MRC-5 and CHO-K1 cells, compared to 23.02 ± 7.25% and 27.03 ± 5.15% for A549 and NCI-H460 cancer cells, indicating that R junceus venom displayed a higher potency again...
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PMC11216402
EMT in cancer is a complex process (Yang et al. 2020; Lovisa 2021), but we found that individual GC cell lines activate the gene expression signature associated with EMT to varying degrees.
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PMC11525028
Univariate and multivariate analyses of prognostic factors for overall survival and LMFS among patients with osteosarcoma, by Wald test.
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PMC11519583
Skeletal muscle mesenchymal progenitors (MPs) play a critical role in supporting muscle regeneration.
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PMC11621493
To understand the regulation of PLA2G4D in more detail, further studies are required, preferably in a cell system that expresses the enzyme endogenously.
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PMC11323699
c Correlation plot displaying plasma TSP-1 levels versus tissue CD47 expression.
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PMC11036064
Overall, hsa-miR-34a-5p increases the anti-tumoral effect of temozolomide on A172 cell apoptosis.
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PMC6163708
Two most important fields (day 9, control and 20 μM GANT61) were quantitated using ImageJ software.
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PMC11657744
Consistent with our in vivo findings and previous studies, the knockdown of Cep89 and Fbf1 did not alter ciliogenesis .
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PMC9429973
PETINT(-) presented a negative predictive value of 95%.
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PMC4355729
AKT-mediated phosphorylation activates components closely related to the cellular filaments which are important for cytoskeleton dynamics34.
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PMC9429973
Results: In a Phase 2 trial in patients with ITP, EFG (10 mg/kg given intravenously) reduced total IgG levels by 63.7% (from mean [SD] 10.6 g/L [5.1] at baseline to 4.1 g/L [2.0]) 3 days after the fourth weekly infusion.
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PMC11413393
RNA isolation was performed using the Qiashredder kit (Qiagen, #79654) and the RNeasy mini kit (Qiagen, #74104).
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PMC11612315
The cells were washed with phosphate-buffered saline (PBS) and fixed with 2% paraformaldehyde for 10 min at 25 °C.
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PMC8068766
As explained in methods, four comparisons were performed separately for day 1, 2, and 3.
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PMC10999934
Scissor requires a single-cell expression matrix, a bulk expression matrix and a phenotype of interest as inputs.
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PMC10040136
3MSC and IM resistance in GIST cells in vitro.
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PMC11290772
Notably, the rate of lysis mediated by ROBO1-NK cells was significantly higher compared with the control group, with a lysis rate of 75% and 79% observed for organoids derived from samples #01 and #02, respectively (Figure 4D).
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PMC10882807
RIP assays and correlation assay estimated that EIF4A3 could interacted with hsa_circ_0005397.
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PMC11700523
Whether MR activation by IS could be suppressed by antioxidants was investigated.
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PMC8864075
C,D) Effects of different concentrations of reTFAE on the expression of EMT-related proteins (n = 3). (
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PMC11788920
The ** symbol in (C) indicates a statistically significant difference compared to TR only case with P< .01.
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PMC10073922
Based on the data presented in figure 4, NDRG2 overexpression reduced the number of migrated and invaded cells compared to the mock and control cells, suggesting the anti-metastatic effects of NDRG2 on A549 cells.
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PMC11543853
The set of template-matched particles was curated by inspecting each matched particle’s position in the tomogram.
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PMC9424261
E, F Production of lipid ROS in (C, D) was measured by C11-BODIPY staining followed by flow cytometry after 10 h of drug treatment: 10 μM erastin or 5 μM RSL3; 10 μM CA; pretreatment with 10 μM CA for 1 h followed by 10 μM erastin or 5 μM RSL3.
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PMC11228511
Bar graph showing the frequency of an abnormal lamin A meshwork in Zmpste24 and Lmnb1 SMCs with and without a nuclear bleb.
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PMC11751675
Grosheimol (1) and cynaropicrin (2) are guaianolide sesquiterpene lactone derivatives formed basically from perhydro-azulen attached to the lactone ring.
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PMC11673128
For fluorescent microscopy co-culture assays, the AS4 cell line was labeled with pHrodo™ Red succinimidyl ester (pHrodo™ Red, SE) (Thermo Fisher), and macrophages were stained with Hoechst 33342 (Thermo Fisher) according to the manufacturer’s protocol .
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PMC8658661
HepG2 is a popular hepatic cell line.
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PMC2614415
Paclitaxel causes cell death by stabilization of microtubule dynamics resulting in activation of the spindle assembly checkpoint and apoptosis .
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PMC11806818
One of the most common applications is to bind nucleic acid aptamers to target molecules for early disease detection and diagnosis.
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PMC6771295
Representative Western blot is shown.
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PMC11747467
Among these, the effect was more serious and significant in luminal cells ( Figure 2C ).
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PMC8481254
The primary antibodies used were anti-YAP (1:100, Abcam, #ab52771), (1:100, Abcam, #ab96718), anti-CDK19 (1:100, Abcam, #ab198843), and anti-cleaved caspase substrate (1:300, CST, #8698).
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PMC11683240
A peptide/protein library derived from human hemofiltrate was screened for inhibitors against PT.
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PMC11772449
Statistical methods: single factor analysis, *P<0.05; **P<0.01; ***P<0.001 In vivo experiments confirmed the synergistic anti-tumor effect of PFD and Sora.
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PMC11478724
Chemotherapy drugs can be effective either by deregulation or modulating MicroRNAs.
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PMC3765139
However, since major differences in the published xenotransplantation models do exist and the conclusion that CSCs are defined by their tumorigenic potential is still discussed controversially , this study focuses on the in vitro identification and characterization of stem cell-like cancer cells in established melanoma...
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PMC11547917
Antioxidant activity with the ABTS method was performed after establishing an IC50 value and the chosen concentration for the ABTS assay was 150 µM for ethanolic extract, and 2 mM for Trolox.
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PMC6461034
The top kinase impact score for each cell line and kinase activity score list was calculated from an INKA (or KARP) analysis of MaxQuant search results.
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PMC11806613
E MDA-MB-231 TNBC cells or BT474 triple-positive BC cells (10 cells) were subcutaneously injected into nude mice.
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PMC9429973
IBD patients with arterial embolism were older (63; Interquartile Range (IQR): 53-74 vs. 56; IQR: 38-70, P <0.001), more common to be females (53% vs. 47%, P= 0.028), more common to have hypertension (38.4% vs. 31.6%, P <0.001), dyslipidemia (35.8% vs. 24.7%, P <0.001), diabetes (20.8% vs. 17.2%, p= 0.008), ESRD (4% vs...
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PMC7039683
Using the genomic DNA isolated from each embryo, PCR was carried out to determine if the reporter construct was present at all, and whether it was (S - single) present at the safe harbor locus in a single copy, (T - tandem), present at the safe harbor locus in more than one copy, or (R-random) was detectable but absent...
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PMC9895440
50 μl of this cell mixture was then plated per microscopy slide well (25'000 T cells and tumor cells respectively).
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PMC7602170
Numerous marker genes are known to have great impact on disease progression and prognosis, even though they are rarely mutated.
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PMC11477621
Hydrogen bonds are formed with His132, Gly140, Asp168, and Phe198.
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PMC11761919
PINs, phthalate inulin nanoparticles; FAdV-4, fowl adenovirus serotype 4; LAB, lactic acid bacteria; HHS, hydropericardium-hepatitis syndrome; DLS, dynamic light scattering; ELS, electrophoretic light scattering; FITC, fluorescein; SDS-PAGE, sodium dodecyl-sulfate polyacrylamide gel electrophoresis; HRP, horse radish p...
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PMC9429973
Apoptosis and mitochondrial depolarization were measured by FACS.
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PMC11681005
MIBC‐specific hypoDMRs were divided into 10 clusters via k‐means clustering, with the first 9 clusters showing histone modifications on either AR, FOXA1, H3K4me3, H3K27ac or H3K27me3 (Figure 1B).
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PMC11240448
Waddington’s visionary introduction of a landscape where cells are symbolized by marbles that roll into different valleys that represent different cell states offers an intuitive visualization that over six decades has proven to be a useful framework for studies in developmental biology and cancer biology .
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PMC9503669
Thus, small molecules that inhibit Nef-dependent kinase activation restore cell growth, providing a straightforward read-out for hit selection.
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PMC9429973
In September 2021, a re-analysis of the Phase 3 trial data revealed that L-gln decreased the number of VOCs by 45%.
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PMC9878278
Similarly, silencing TLR9 using siTLR9 (that reduced gene expression by >70% without affecting the viability, data not shown) also did not change the trend of ZIKV replication (Figure 2F).
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PMC11413393
Putative proximity interactors were identified using Significance Analysis of INTeractome (SAINT) comparing Flag- miniTurbo-only samples to Flag-miniTurbo-PRMT1 samples using a Bayesian false discovery rate (BFDR) cut-off of ≤0.01 (1%).
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PMC11172027
We used MTC-SK cells, a medullary thyroid cancer cell line, and tested the behavior of NASeLM and the non-selenium-containing amino acid NALM.
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PMC8303372
On the first day, 500 µL of DMEM were added inside the wells of the ECIS culture array, connected to the ECIS instrumentation.
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PMC9621239
Furthermore, we investigate the distribution of different genotypes in the intra-patient liver microenvironment in patients with HCC co-infected with multiple-genotype HBV.
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PMC11407042
Seed 1.5×10 cells into each well in a total volume of 100 μL. Shake the plate gently, and observe under the microscope to ensure cells have spread evenly.
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PMC11697703
Lentivirus vectors were modified from the pSicoR backbone, a gift from Tyler Jacks (Addgene plasmid # 11579).
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PMC9429973
To study the effect of succinate on leukaemic progression, we used two different mouse models, i.e. Mx1-Cre Nras and MLL-AF9 knock-in (KI).
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PMC9429973
The mean duration of symptoms is 13.6 days.
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PMC9219615
In contrast, in mitochondria that have lost membrane potential, the dye can no longer accumulate and emits green fluorescence.
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PMC9429973
The median age at diagnosis was 65 years old with male predominance.
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PMC11627398
Thus, we suggest that these four genes may be associated with the host immune response in septic shock.
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PMC9429973
InO has been added to low-intensity chemotherapy, but the risks/benefits of such combinations are poorly defined.
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PMC11401350
To overcome this problem, we can envisage several solutions to eliminate specifically the CAR T cells in vivo.
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PMC11576293
Crystal data: C24 H19 Cl N2 O S, MW = 478.99, Orthorhombic; a = 6.193 (2) Å, b = 14.250 (5) Å, c = 23.313 (6) Å; a = 90°, β = 90°, y = 90o; V = 2057.38 A; space group P212121, Z: 4 and Z': 0; Dc = 1.352 g cm.
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PMC11695623
In addition, we also found that DCUN1D5 has a good diagnostic value for LUAD and the overall survival time of patients with high expression of DCUN1D5 is shorter.
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PMC9429973
Summary/Conclusion: Our study indicates that a portion of patients with preeclampsia has increased complement activation and decreased ADAMTS13 activity.
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PMC11474209
Table 2S.
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PMC11257988
When KRAS protein binds to GTP, it is in an active state, and when it binds to GDP, it is in an inactive state.
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PMC11700165
ITK-SYK, ITK-SYK-KD, and SLP-76 have been previously described.
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PMC11718031
It was observed that when CD-CHO was used as the basal medium, all the feed supplements except Efficient A plus and Ex-Cell Adv-CHO feed1 maintained a pH of around 7.1 ± 0.2.
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PMC7759933
Subsequently, the UGT1A1 mRNA level decreased (4.13-fold at day 14) and remained constant during further cultivation.
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