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OTAR3088
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BioData-CellLine_annotated

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PMC11638255
For mesothelioma tumors, fresh sections were roughly minced and incubated in a tumor digestion mix consisting of PBS/2% FBS supplemented with 100 μg/mL DNase I (Worthington Biochemical, USA; #LS006331) and 1.5 mg/mL Collagenase IV (Sigma-Aldrich, USA; #C4-22-1G) for 1 h at 37 °C at 180RPM.
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PMC11742864
Previous studies revealed that taking ω-3 LCPUFAs supplements at a dose of 3.6 g/day reduced the inflammatory markers C-reactive protein (CRP) and PGE2.
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PMC10890055
The decrease below the normative cut-off was observed at a concentration of 140 μmol∙L. The possibility of G418 influencing the metabolic activity assay was excluded, because the medium with G418 was removed prior to the addition of ZnCl2 solutions.
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PMC9429973
At diagnosis, 23% had an ECOG performance status ≥2, 68% had Ann-Arbor stage III-IV, 63% had increased lactic dehydrogenase levels and 77% had extranodal disease (24% >1 site).
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PMC11703992
Bioinformatic analysis revealed that NF-κB/MAPK pathways were closely related to DDIT4+ Memory T cells.
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PMC4355729
A value of p less than 0.05 (* P < 0.05, ** P < 0.01) was regarded statistically significant.
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PMC11742864
Among them, is the consumption of different long-chain polyunsaturated FAs (LCPUFAs) in several prospective and case-control studies.
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PMC11754291
Before use, irradiated fibroblasts were thawed and seeded at 8,000 cells/cm in T75 flasks using a medium consisting of a 3:1 mixture of DMEM and Ham’s F12 (Invitrogen, Waltham, MA, United States) supplemented with 5% Fetal Clone II serum (HyClone, Wilmington, DE, United States), 5 μg/mL insulin (Sigma-Aldrich, St. Loui...
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PMC10734950
For this purpose, the Annexin V-FITC and propidium iodide (P.I.) assay and a flow cytometry protocol was utilized .
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PMC10213179
Supernatant from this incubation was then transferred to target protein immobilized on magnetic beads and again incubated at 37°C for 30 min for the selection step.
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PMC11706297
Prime automatically added the missing chains and PropKa measured the protonation state at physiological pH. The LigPrep module was applied to BTT-1–10, BTP-1–10, and lapatinib for preparation with energy minimization at physiological pH. Maestro’s grid generation was used to determine the docking grid, which was then a...
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PMC11791203
The three dimensional conformer structures of the compounds with favourable ADME parameters obtained from GC-MS of the chloroform extract were retrieved from the PubChem compound repository and converted into PDBQT files using the MGLTools 1.5.7 within AutoDockVina.
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PMC10976516
An example are myeloma cells expressing CXC chemokine receptor 4 (CXCR4) and thereby facilitating their homing into bone marrow, as has been shown in a study by Liu et al. with myeloma cells infected with the measles virus.
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PMC11762280
Regulatory cell death (RCD) is a type of cell death that depends on specific molecular mechanisms that are controllable and reversible .
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PMC6222726
The leaflets are velvety, 1.3 to 5 cm long, 0.5 to 2 cm wide, and have toothed margins.
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PMC11144382
Furthermore, the establishment of an RA gradient across the brain is required during development.
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PMC11740207
These findings are relevant in both preclinical and clinical trials—provided that in vivo counterparts are included—and aid in selecting the most efficient and least toxic drugs.
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PMC9512971
As a sensitivity analysis, we investigated the influence of patients who tested positive for SARS-CoV-2 after conversion to a SARS-CoV-2-negative status.
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PMC6024716
Higher specific and total luciferase activity observed in the OAZ1 knockout cell lines (Figure 4a) were the result of an increase in both mRNA (Figure 4b) and protein expression (Figure 4c).
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PMC7612475
Whilst a number of studies have linked loss of mRNA splicing machinery components with aberrant DNA damage response (DDR) activation and/or defective DNA repair (1, 30–32), it is clear that the majority of somatically acquired mutations in spliceosome genes do not lead to a loss function.
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PMC11790599
Surviving colonies were washed with phosphate buffer saline (PBS, Invitrogen), stained with 0.2% (w/v) crystal violet (Sigma Aldrich) in buffered formalin (Sigma Aldrich) for 10 min, and photographed using a GelDoc XR Imaging System (Bio-Rad).
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PMC10812665
A secondary screen was performed in iPSC-derived peripheral neurons, which essentially confirmed the NeuriTox hits , but did not yield additional mechanistic information.
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PMC5308810
Data are presented as mean tumor volumes (mm) ± SD versus time (two-way ANOVA, ***p<0.001). (
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PMC11489175
The different OTUs display specificity for different chains.
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PMC9429973
Eleven cases which were scored negative for CD26+ LSCs were also found to be negative for any BCR-ABL transcript.
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PMC8567602
F, Optical densitometry–quantified gradients of SMARCB1 and PBRM1 depict overlap among the glycerol gradient fractions in two human synovial sarcoma cell lines and a mouse synovial sarcoma tumor.
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PMC9429973
However in real-world practice, adhering to this intensified regimen was difficult and doses were rarely escalated beyond level 2.
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PMC11438317
We also show that LYP co-localizes with SLP76 in microclusters, upon TCR engagement.
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PMC4485648
Extracellular pH was measured in cell culture media as described earlier (21).
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PMC11687167
Treg cells represent 5–10% of the peripheral blood (PB) CD4 + T-cell population and play a central role in modulating various immune responses and silencing self-reactive T cells .
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PMC11539788
C-D) qRT‒PCR was performed to detect ILK mRNA levels after RNF19A was overexpressed or knocked down. (
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PMC11746942
C Representative immunohistochemistry images showing the expression of CD31, K16, K17, Ki67, P-STAT3, and Src in dorsal skin sections from mice treated with solvent control, IMQ, IMQ + TY, or TY alone.
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PMC9429973
HLA matching was well-balanced in 3 groups.
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PMC11216402
We used a panel of GC-derived cell lines in combination with the TCGA stomach-adenocarcinoma (TCGA-STAD) cohort to identify heterogeneous regulatory programs in GC and their concomitant transcriptional responses.
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PMC11740573
Then, 100 ul of fresh bacterial suspensions at 0.5 on the McFarland scale were added to each well, as well as calcitriol in an amount so that its final concentration in the well was near the physiological level of 100 ng/ml .
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PMC6461034
Plotted is the INKA score for ATM, exhibiting a time‐dependent increase, which is not observed with ATM blocking.
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PMC7987994
This provides that buffering capacity and osmolarity will not be severely altered and ensures conditions better mimicking those in vivo with body fluid circulation and removal of the degradation products from the site of implantation.
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PMC11637276
Indeed, α2 integrin inhibition or down-regulation significantly decreased the uptake of collagen I-rich matrices in MDA-MB–231, A2780-Rab25, YEJ P, and SW1990 cells.
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PMC11774251
HaCaT cells at over 60% confluence in 12-well plates were treated with Tan-I for 6–8 hours, followed by TNF-α (100 ng/mL, Sino Biological, Beijing, China) co-stimulation for 24 hours.
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PMC8633974
Eighty-six and a half percent of the gated live singlet U1 cells were positive for GFP expression on an average, and ≥98% of the gated live singlet JLat 8.4 cells showed GFP expression.
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PMC7192625
We constructed networks from the CHiCAGO output, simply considering all contacts with CHiCAGO score >5 as edges, as suggested by the package guidelines.
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PMC9429973
Ferritin, thyroid hormone, vitamin B12 and B9 levels were normal.
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PMC4369959
In this paper, the role of ginger and its active ingredients against GI cancer have been discussed as it has worldwide consumption as a spice.
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PMC10965315
Harmaline was added to the cell suspension at concentrations of 37.5 and 75 μM, and the cells were incubated for 24 h. A2780 cells invaded and passed through a layer of polymerized collagen, attaching to the bottom of a polycarbonate membrane.
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PMC8316344
NS non-significance; **P < 0.01; ***P < 0.001; ****P < 0.0001.
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PMC9429973
Image: Summary/Conclusion: The combination of itacitinib 200 mg daily and CAMPATH in pts with T-PLL was safe and well tolerated with no dose-limiting toxicities.
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PMC9429973
Ruxolitinib (RUX), a JAK1/2 inhibitor, was the first therapy for intermediate- and high-risk MF approved in the United States; however, a high unmet need remains for alternative treatment options for patients who discontinue or are no longer responding to RUX.
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PMC11785489
After training, the TCR sequence feature weights were fixed, and the resultant TCR scoring function can be applied to external data (e.g., Datasets 3–6).
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PMC10719213
We used next-generation amplicon sequencing to screen the mtDNA for mutations.
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PMC11754436
DHRS4-AS1 served as a tumor suppressor gene that regulated the proliferation and apoptosis of OS cells.
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PMC11661024
Hence, the interest is progressively changing from live probiotic bacteria to non-viable postbiotic products.
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PMC9370419
By screening a drug library using SBHX21 cells, we identified estradiol benzoate as a novel anti-HBx agent.
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PMC6114978
These findings were mirrored in sarcoma cell lines that demonstrated constitutive activation of TAZ/YAP which demonstrated a similar frequency with regards to loss of expression of at least one of the Hippo kinases (83%) (Figure 7A). (
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PMC11779876
Only productive rearrangements were used for downstream analysis.
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PMC10729469
APP/PS1 mice were untreated or treated with TCRAβ-Tregs, polyclonal Tregs (Treg) or EV-Tregs (TCR-Tregs electroporated with empty plasmid vector) by adoptive transfer and brain tissues acquired 3 weeks post adoptive transfer A. ELISA performed to quantify Aβ1–42 levels in the brain using Tris–HCl (soluble) and guanidin...
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PMC11637276
Macropinosome acidification has been shown to occur within 5 to 10 min after macropinosome formation , which is in agreement with our live cell imaging observations, where pHrodo-collagen I fluorescence increased approximately 12 min after internalisation.
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PMC11470999
Other drawbacks of intracarotid arterial injection include technical challenges and significant trauma to the mice, with a mortality rate reaching up to 30% when using certain cells to establish the model.
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PMC10969097
Other organs, such as the kidneys, intestines, bone marrow and peripheral blood, were histologically evaluated to measure the impact of the treatment on neighbouring tissues .
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PMC11787651
C, the number of peptides identified by each method with a retention time CV below 20% and below 5%, and the number of peptides with peptide ratio CV below 20% and below 5% across all control replicates.
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PMC6684588
In a reporter-gene assay conducted with a human rhabdomyosarcoma (A204) cell line, ACE-083 inhibited signaling by activin A, activin B, myostatin and GDF11 in a dose-dependent manner, with IC50 values ranging from approximately 40–700 pM (Table 1) or, in alternative units, 5–80 ng/mL (see Supplementary Fig. S2).
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PMC9596868
Values represent mean ± SD of three independent experiments for PA-1, A2780 and OVCAR3 cell lines and of two independent experiments for OSE cell line, respectively, analysed by ANOVA with Dunnett's Multiple Comparison test. *
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PMC9429973
We analyzed therapy results from 50 pts.
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PMC11496728
Based on the copy number analysis results, the transient expression levels of SEAP and IL-3 are not closely related to the gene copy number.
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PMC11779605
The dotted horizontal line represents a Q value of 0.05, and the dotted vertical lines represent a Log2 fold change of 1.5 or −1.5. (
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PMC11733919
After functionalizing the MNPs with STV, the supernatants were collected for quantification by the Bradford assay.
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PMC9429973
Median duration (range) of exposure was 103.1 (0.1-201.1) wk on asciminib and 30.5 (1.0-188.3) wk on BOS.
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PMC10956161
A previous study found that PRDX6 gene expression was markedly higher in non-small cell lung cancer tissues than in adjacent tissues, which seems consistent with the current findings.
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PMC9429973
The fraction of neutralizing Abs (NAbs) against SARS-CoV-2 spike of Wuhan-Hu-1 strain and five variants (alpha, beta, gamma, delta and Omicron) was assessed in the collected sera by a SARS-CoV-2 pseudovirus neutralization assay.
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PMC11768927
For example, Cook et al. reported regression of lymphatic lesions in patients with relapsed refractory T-cell lymphoma following a single dose treatment with VSV- IFNβ-NIS (NCT03017820), establishing the safety of the IFNβ sodium symporter strain and its association with tumor regression.
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PMC11792888
Cells were seeded in 96-well plates, treated for 72 h, and analyzed by MTT assay. (
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PMC11753541
However, conventional incubators are expensive, space-occupying, and additional investment for a dermatosurgeon.
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PMC11687167
A Schematic representation of PCSK9 gene structure.
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PMC9429973
Any-grade NEs were seen in 31% (n = 19) of patients; grade 3 NEs occurred in 5% (n = 3) of patients and no grade 4/5 NEs were reported.
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PMC11632064
Oligonucleotide primers were designed using Primer Blast software (NCBI), synthesized by Integrated DNA Technologies (IDT), and validated for efficiency and specificity.
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PMC10253973
These complexes were localized in the nucleus; they luminesced between 670 and 710 nm and generated singlet oxygen and radicals.
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PMC11422150
The quantification of TSG6 showed an increasing trend with hAMSC treatment, but no significant difference was observed (2.04 ± 0.37, P = 0.10, Figure 4D).
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PMC11394227
Adherent cell culture: The CHO series of adhesion cells were cultured using Ham’s F-12 medium (Gibco Life Technologies) with 10% fetal bovine serum and 1% penicillin-streptomycin amphotericin (Solarbio, Beijing, China) in a cell incubator at 37 °C in a humid environment of 5% CO2.
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PMC11740907
It also suggests better holding capacity and suitability of SLNs for P5W30.
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PMC9429973
Studies involving larger cohorts who have higher bone marrow involvement ratios consistent with the literature are undoubtedly needed to support this proposition.
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PMC11301242
Juan Cheng: Methodology, Resources, Writing – review & editing.
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PMC11502327
For example, the killing activity of its long-chain ester derivatives on liver cancer cell lines is 5.4 times that of Chrysin, and its porphyrin derivatives can be used for non-invasive photodynamic therapy of cervical cancer and gastric cancer (181).
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PMC11453018
In summary, we demonstrate that both EWS::FLI1 and EWS::ERG cooperate with P300 to maintain LMNB1 expression and evade senescence-related processes in Ewing sarcoma.
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PMC10114490
Briefly, Hoechst 33,342 nucleic acid stain was used for sensitive and accurate cell number determination, PI exclusion for cell viability and exclusion of death cells in HCS analysis, TMRM for mitochondrial membrane potential and CellROX dye as an indicator of oxidative stress damage.
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PMC8973725
Moreover, the expression of the ZNF677 protein was gradually decreased in the primary tumor and metastatic tissues: (a) normal tissue, (b) non-metastatic cancer tissue, (c) metastatic cancer tissue. (
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PMC11026382
We constructed a mathematical model relating changes in DHFR and TYMS catalytic parameters to growth rate phenotype.
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PMC11775197
The Wnt/β-catenin pathway negatively regulates mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) via PPARγ signaling.
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PMC11576293
Taking all these findings about these new pyrimidines revealed a common observation, that such a class of compounds performs better biological activities within all tested biological systems when having low lipophilicity characters.
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PMC11658074
c Quantification of AT-EVs and ADSC-EVs in 10 ml of AT.
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PMC11718817
If the variances differed significantly, Welch’s correction was performed.
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PMC10040136
The cell suspension is then filtered through a 40-μm cell strainer to remove any remaining tissue debris.
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PMC11389534
To avoid the harmful pathology, the immune system has developed sophisticated and multilevel regulatory mechanisms.
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PMC9429973
85 (43.1%) of patients included in the study do health research on the internet, and 181 (90.5) think e-health tools may help them to improve the communication with the medical team during their treatment.
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PMC11478724
These findings were consistent with the Buqué et al. (2012).
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PMC6133382
As sialic acid is a major receptor for MVM infectivity, the MGAT1 CHO cell line we created might have the additional manufacturing benefit of being resistant to MVM infection .
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PMC11765243
On day 10 after immunization, the mice were euthanized before obtaining lymphoid organs or blood by cardiac puncture.
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PMC11453018
D The comparative Venn diagram illustrates the overlap between DEGs in iP300w-treated cells and EWS::FLI1 knockdown cells.
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PMC11792740
CAR TILs deficient in both TOX and TOX2 (Tox DKO) were more effective than wild-type (WT), TOX-deficient, or TOX2-deficient CAR TILs in suppressing tumor growth and prolonging the survival of tumor-bearing mice.
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PMC11306331
B Data was binned based on the MBP concentration.
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PMC11474209
Understanding these processes is crucial for developing interventions to mitigate health risks associated with chronic exposure to microcystins.
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PMC10125312
Both lung cell lines seemed to recover some mitochondrial activity at 24 h after irradiation, and the differences found immediately after treatment faded after 24 h. In contrast, the hepatic cell lines had very similar viabilities immediately after treatment, but after 24 h significant differences were found after a dr...
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