OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11790971	For the three passages, the balanced accuracies and impurity scores of individual cross-validation folds are shown in Fig. 6a–c. Bar plots in Fig. 6d–f show the mean and standard deviation of classification performance for different imaging modalities across passages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7022782	Fluorescence measurements were recorded at 0, 1, 2, 3, 4, 7, 10, 20, and 30 days and the time-dependent decay of ICG fluorescence was investigated and expressed as a percentage (%) of fluorescence remaining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Mean patient age was 68.5 years (range 40-89 years).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Mean", "patient", "age", "was", "68.5", ...
PMC11621493	The flow rate was 0.15 ml/min and the column was kept at 50°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "flow", "rate", "was", "0.15", "ml/min", "and", ...
PMC11637276	Cell detachment.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Cell", "detachment", "." ] } ]
PMC9429973	Pts with DS 3 and 4 completed 6 ABVD and IFRT on PET-CT positive areas.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "with", "DS", "3", "and", "4", "completed", "6"...
PMC11469524	However, as our modeling technique employs a greedy hill climbing link adjustment strategy, the resulting networks may represent a local optimum.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...
PMC10170482	Further, analysis of vinculin distribution showed that in cells grown in soft 3D CS, vinculin was spot-like randomly distributed, whereas in stiff MC conditions, vinculin was allocated with F-actin fibers at the cellular border (Figure 3D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7709199	The crystal structure of murine IL-12B presented here (Fig. 3 ▸ b) displays high overall structural similarity to human IL-12B (r.m.s.d.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11737091	The initiation of DNA replication is critically dependent on the activation of DBF4-dependent protein kinase (DDK) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "initiation", "of", "DNA", "repl...
PMC11782508	The FTIR spectrum was recorded at room temperature in the mid-infrared region (400–4000 cm⁻¹).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "FTIR", "spectrum", "was", "recorded", "at", ...
PMC11564322	It should be noted that the effect of EDPs depends on the concentration, form of administration, exposure time, and tissue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", ...
PMC5941560	Short and long insertions and deletions were defined using a cutoff of 50 bp, in accordance with the structural variant databases from NCBI .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7185206	Further, sPD-L1 derived from a subset of tumor cells may protect distant malignant cells from anti-tumor immunity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", ",", "sPD-L1", "derived", "f...
PMC11297139	Lastly, DNA was purified using MinElute PCR Purification Kit (QIAGEN).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lastly", ",", "DNA", "was", "purified", "using", "MinElute", "PCR", "...
PMC11144200	The long-term viability of adaptive effector T cells appears to be necessary for the sustained remission of solid malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "long-term", "viability", "...
PMC10538569	stands for P values = or < 0.001. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "stands", "for", "P", "values", "=", "or", "<", "0.001", ".", "(" ] } ]
PMC9681981	Then, the cells were cultured in 24-well plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "the", "cells", "were", "cultured", "in", "24-well", "plates", "." ] } ]
PMC11171319	In fact, we isolated HCMV clinical strains in our laboratory, namely HCMV-DB and BL, which fully replicate in human mammary epithelial cells (HMECs), ovarian epithelial cells (OECs), prostate epithelial cells (PECs), and astrocytes followed by their transformation with the appearance in cultures of CMV-transformed HMEC...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-...
PMC9429973	Our study concerned patients diagnosed with COVID-19 during this period.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "study", "concerned", "patients", "diagnosed", "with", "COVID-19", "during", "this", "peri...
PMC6133382	GNA does not require Ca or Mg cofactors to bind, allowing the use of 10 μM EDTA to ameliorate cell clumping during repeated centrifugation and wash steps.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803210	MCF-7 cells were treated with vehicle control (0.1 % DMSO) or 10 µM naringenin for 24 hours, then total RNA was isolated from samples for sequencing.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627133	Quantification of SpyRho fluorescence intensities (mean±s.d.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "SpyRho", "fluorescence", "intensities", "(", "mean±s.d", ".", "," ] } ]
PMC9429973	The estimated 1 year PFS was 68.5%(95%CI 21.3% to 92.2%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "estimated", "1", "year", "PFS", "was", "68.5%(95%CI", "21.3", ...
PMC9429973	No patient discontinued asciminib solely due to intolerance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "patient", "discontinued", "asciminib", "solely", "due", "to", "intolerance", "." ] } ]
PMC10114490	Orange: NES > 0, enriched in diHLC-T. Blue: NES < 0, enriched in iHDF-T. Red line marks FDR = 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6461034	The arrow indicates MET, a receptor tyrosine kinase that is in the INKA top 20 for CRC0254, but not CRC0177.Scheme indicating signal transduction pathways of IGF1R/INSR, EGFR, ERBB2, EPHA2, and MET.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11697703	For miR193b-miR-365 GoF experiments, we confirmed that co-electroporated miR193b-miR-365 constructs were co-expressed in neurons (Figure S2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "miR193b-miR-365", "GoF", "...
PMC6160470	Calcein accumulation should not be affected by compounds that alter mitochondrial or plasma membrane potential, as compared to Rho123, which is a positively charged molecule.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Cox proportional hazards model was used for multivariate analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cox", "proportional", "hazards", "model", "was", "used", "for", "multivariate", "analysis", "." ] } ]
PMC7452526	It has a high capacity of reducing the cell viability percentage lower than 10%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "a", "high", "capacity", "of", "reducing", ...
PMC9473868	These results indicated BAI could induce SW982 cells apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "These", "results", "indicated", "BAI", "could", "induce", "SW982", "cells", "apoptosis", "." ]...
PMC10975211	Future clinical trials will be crucial in assessing the safety and efficacy in human subjects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Future", "clinical", "trials", "will", "be", "crucial", "in...
PMC11046454	Structures of aptamer-functionalized CAR.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Structures", "of", "aptamer-functionalized", "CAR", "." ] } ]
PMC11216402	Variation in the chromatin accessibility profiles across GC cell lines is consistent with differential TF activity inferred from sequence-based machine learning. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Variation", ...
PMC10772747	For experiments, T47D cells were used at 80-90% confluence (Amalina et al., 2023).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "experiments", ...
PMC11488203	Data represent the mean ± s.d. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represent", "the", "mean", "±", "s.d", ".", "(" ] } ]
PMC8916024	In our study, Proteobacteria as identified as one of the main bacterial phyla in sediment, which was consistent with a previous report that Proteobacteria was the most abundant flora in rice field sediment (Chen et al., 2012; Zhao et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The products of BCL2 and its homologues, including BAX and BCL2-like 12 (BCL2L12), are implicated in CLL, as apoptosis regulators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8358006	The biological associations with H3K27me3 dysregulation may be attributed to the function of the tissue and the pathophysiological status of the model in relation to the ongoing gene expression programs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11704135	By chelating these ions, the derivatives prevent their participation in Fenton and Haber-Weiss reactions, which generate highly reactive hydroxyl radicals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "chelat...
PMC9429973	Sometimes the language used by reporters reflects the uncertainty in the diagnosis due to atypical appearances or other tests not being consistent, the fact that tests are incomplete or clinical information is missing from the referral.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519583	These findings indicated that Wnt5b and Wnt11 synergistically contribute to excessive MP proliferation and IMAT accumulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "indicated", "that", "Wnt5b", "and...
PMC11422497	Histological changes, Ki-67 staining, and TUNEL assay were performed on the subcutaneous tumor tissues to comprehensively examine the impact of circRNA on GISTs cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11285179	Enrichment analysis of gene pathways showed that RA signaling pathways were activated after CCL28 stimulation (Fig. 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enrichment", "analysis", "of", "g...
PMC10114490	A complete list of differentially expressed genes is included in Additional file 2: Table S4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "complete", "list", "of", "differentially", "expre...
PMC3888431	Nowadays, related CHO cells are the most commonly used cell lines in modern research and biotechnology .	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nowadays", ",", "related", "CHO", "cells...
PMC11411004	To detect the active HDAC isoforms, 2 μM I-4 was applied to CHO-ADM monoclonal antibody cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "To", "detect", "the", "active", "HDAC", ...
PMC11794588	Ten phototropic nauplii were introduced to each container and cultured for 24 h at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ten", "phototropic", "nauplii", "were", "introduced", ...
PMC9429973	Results: We identified six patients with monoallelic germline IKZF2 mutations (one nonsense (p.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "We", "identified", "six", "patients", "with...
PMC11739504	These results establish a link between acetylation regulated by Kat2b and its relevance to ciliary assembly and function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "establish", "a", "...
PMC11471157	The hydrolysate was then derivatized using the AccQ-Tag Ultra Derivatization Kit (Waters, MA, USA), and the derivatives were analyzed via pre-column derivatization HPLC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700165	Graphic representation of the kinases investigated. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Graphic", "representation", "of", "the", "kinases", "investigated", ".", "(" ] } ]
PMC11792888	In this work, we evaluate the effects of R. junceus venom on cell viability in non-cancerous and cancerous NSCLC cell lines using cell viability assays, flow cytometry, and Western blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC11451940	Moreover, the following human carcinoma cells were also used for studies with 24 h incubation time: cisplatin-resistant ovarian carcinoma (A2780R), breast adenocarcinoma (MCF-7), prostate adenocarcinoma (PC-3), lung adenocarcinoma (A549) and bone osteosarcoma (HOS), which were obtained from ATCC collection of cell line...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11265931	In conclusion, the evidence provided here clearly suggests that garlic SEVs have therapeutic potential on cancer cells while having no cytotoxic effect on the healthy cell line HUVEC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11317131	We observed evolved libraries increase efficiency by 15.4, 70.2 and 20.9-fold over P1, P2 and P3, respectively (Figure 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11670954	Furthermore, a separate study demonstrated that LPS increases the mRNA expression of RhoA , ROCK2 , and MLCK , leading to alterations in their distribution within Caco2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11506670	Lastly, cell fusion—a result of aberrant mitosis sometimes observed in some malignancies —can be observed in cells transfected with NRAS E37K.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	However, with the average age of AML diagnosis being approximately 70 years, many AML patients are ineligible to receive IC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",...
PMC8540611	In the following, only AuNP14 and AuNP15 effects on the HL-60 and CEM-SS cell lines will be considered since AuNP13 affected the target siRNA in any case, and there was no effect from the use of the target siRNA for HeLa cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10940855	Right, mean levels of total Annexin V cells within each treatment group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Right", ",", "mean", "levels", "of", "total", "Annexin", "V", "cells"...
PMC11680578	Synergistic treatment of paclitaxel (PTX) and rosiglitazone (RGZ) on the cell cycle of SKOV-3 ovarian cancer cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Synergist...
PMC5035325	Animal’s procedures were performed in accordance with the guidelines stipulated by Animal Subject Committee Review Board of the CIM and CIM”s Institutional Animal Care and Use Committees.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This result suggests that part of the resistance mechanism is transcriptionally mediated and virtually common to several SI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "result", "suggests", "that", "...
PMC11323699	Considering the therapeutic relevance of targeting the CD47/TSP-1 axis, we used the CD47-derived TAX2 peptide to selectively antagonize it in a preclinical model of aggressive ovarian carcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11506827	The cells (2.5 × 10 cells/well in 60-mm dishes) were seeded and allowed to adhere overnight before pre-treating with GEF or DMSO for 12 h in a serum-free medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4005030	Salvia miltiorrhiza has long been used in the traditional Chinese formulations for the treatment of heart ischemic diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Salvia", "miltiorrhiza", "has", "long", ...
PMC11352666	Moreover, MERTK inhibition may be particularly effective in combination with chemotherapy and targeted agents .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "MERTK", "inhibition", "may", "be", "partic...
PMC11787651	The microflow system provided stable and reproducible retention time information comparable to results from the nanoflow system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "microflow", "system", "provided", "stable"...
PMC8956657	The IMPα3 is shown in dark gray and surface mode, and the p50 is shown in orange in stick mode.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IMPα3", "i...
PMC4816271	The plate was centrifuged at 1000g for 40 minutes at RT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plate", "was", "centrifuged", "at", "1000", "g", "for", "40", "minu...
PMC9786247	Neither of the strains induced detectable IL-1β, IL-6 and TNF-α host cell responses at 1 d p.i. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Neither", "of", "the", "strains",...
PMC11637276	Collagen I was dissolved in ice-cold PBS to a final concentration of 1 mg/ml, and 100 μl of the solution was used to coat a 35 mm glass-bottom dish with the help of a pipette tip.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11128598	The cell line A-172 was the one with the lowest CI (0.06), despite of using lower CQ doses than in the rest of the cell lines assayed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706491	To assess the impact of conditional Sty1 inactivation, we analyzed asynchronous cultures of wild-type and sty1-as strains treated with 3-MB-PP1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "assess", "t...
PMC7185206	In our Cox proportional hazards models, low PD-L1 protein-to-mRNA ratios predict strikingly poor outcomes in papillary renal cell carcinoma (Figure 1(c)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11243198	These findings further support the inhibitory activity of the GANT61 analogs on the Hh pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "further", "support", "the", "inhibitory", ...
PMC10545062	It is worth noting that two outlier animals were observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "worth", "noting", "that", "two", "outlier", "animals", "were", "observed", "."...
PMC11740907	Another peak was shown at 907.60 cm in region of fingerprint due to bending type vibrations at W=O. Very strong and broad W-O-W stretch pattern at 732.42 cm was observed.46 BW showed C-O stretch in fingerprint region at 1377.25cm and an intense peak was also noticed at 659.73 cm because of bending vibrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10994876	This process plays a crucial role in YAP-induced cell proliferation and growth promotion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "process", "plays", "a", "crucial", "role", "in", "YAP-induced", ...
PMC3203927	These results are supportive of further cytokine identification and validation studies with cells from non-neural tissue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "are", "supportive", "of", "further...
PMC9352806	Saponins from bitter melon (BMS) are well-known to have various biological activities, especially in the field of fat-lowering.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Saponins", "from", ...
PMC9429973	The proportion of patients on ruxolitinib (rux) with a negative or borderline response after two doses was higher than observed in other patients (5/10 vs 5/47, p=0.01).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The majority of pts (71/86 (83%)) had IPI score 3-5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "majority", "of", "pts", "(", "71/86"...
PMC10135767	These findings provide new insights into the mechano-chemical regulation mechanism for adhesion molecule-mediated intracellular signaling pathways, providing a basis for the development of novel concepts in risk assessment, clinical diagnosis, and the effectiveness of inflammatory disease and cancer treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	Nevertheless, the kinetics displayed a general alignment in comparable ranges, reinforcing our findings that the full agonist DAMGO elicits activation of the MOR at a notably faster rate compared to the partial agonist morphine (sensor: 75× faster, receptor:G-protein interaction: 20x faster).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7723249	Polarization of human epithelial cells leads to a different pattern of surface proteins on the apical side compared to the basolateral side.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Polarization", ...
PMC9776316	Consistent with the decreased cell viability, the IC50 of cisplatin in the XRCC4 knockdown cells was also significantly lower than in the control cells (Figure 2c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11438317	Thus, interactions of these proteins, which are critical for T cell activation and are dependent on tyrosine phosphorylation, seem to be regulated by LYP, which rather than targeting a particular protein, dephosphorylates several adaptor proteins that are part of the microclusters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	Other kinases, including AKT2, RPS6KB1, and RET, showed similar behavior.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "kinases", ",", "including", "AKT2", ",", "RPS6KB1", ","...
PMC11594074	In these cells, the reporter genes were controlled by a cytomegalovirus (CMV) promoter, which is sensitive to the methylation status .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11185260	ImageJ software was used to calculate tumor volumes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ImageJ", "software", "was", "used", "to", "calculate", "tumor", "volumes", "." ] } ]
PMC10877303	In the P1 position of the substrate, the glutamine (Q) residue is essential, while the P2 position strongly prefers a leucine residue .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9910796	H-K) Immuno-EM of ER-associated zippers with antibodies to luminal ER marker PDI (H), pp220 (I), pp62 (J) and pEP84R (K).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635087	Isolated chloroplasts are enclosed by a double envelope membrane and have multiple layers of thylakoid membranes, which do not form grana stacks in the chloroplasts of land plants (Fig. 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240571	Male BALB/c nude mice (8 weeks old) were purchased from Clair (Tokyo, Japan) to establish the xenograft model.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11791264	A, SKOV3 cells were stably transfected with control vector (pCDH) or pCDH-SETD7 in the absence or presence of bafilomycin A1 (Baf A1, 100 nM) for 10 h. The lysates were immunoblotted with the antibodies indicated on the right.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706776	Reverse Transcription (RT) was performed from 1 µg of RNA with the “Maxima H Minus First Strand cDNA Synthesis Kit” (Macherey-Nagel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	AM-exposed AdCAR-T were co-cultured with OCI-AML-3 (21 d vs 7 d AM exposure, followed by 7 d AM absence).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AM-exposed", ...

PMC11790971

For the three passages, the balanced accuracies and impurity scores of individual cross-validation folds are shown in Fig. 6a–c. Bar plots in Fig. 6d–f show the mean and standard deviation of classification performance for different imaging modalities across passages.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7022782

Fluorescence measurements were recorded at 0, 1, 2, 3, 4, 7, 10, 20, and 30 days and the time-dependent decay of ICG fluorescence was investigated and expressed as a percentage (%) of fluorescence remaining.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Results: Mean patient age was 68.5 years (range 40-89 years).

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PMC11621493

The flow rate was 0.15 ml/min and the column was kept at 50°C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "flow", "rate", "was", "0.15", "ml/min", "and", ...

PMC11637276

Cell detachment.

[ { "tags": [ "O", "O", "O" ], "tokens": [ "Cell", "detachment", "." ] } ]

PMC9429973

Pts with DS 3 and 4 completed 6 ABVD and IFRT on PET-CT positive areas.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "with", "DS", "3", "and", "4", "completed", "6"...

PMC11469524

However, as our modeling technique employs a greedy hill climbing link adjustment strategy, the resulting networks may represent a local optimum.

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PMC10170482

Further, analysis of vinculin distribution showed that in cells grown in soft 3D CS, vinculin was spot-like randomly distributed, whereas in stiff MC conditions, vinculin was allocated with F-actin fibers at the cellular border (Figure 3D).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7709199

The crystal structure of murine IL-12B presented here (Fig. 3 ▸ b) displays high overall structural similarity to human IL-12B (r.m.s.d.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11737091

The initiation of DNA replication is critically dependent on the activation of DBF4-dependent protein kinase (DDK) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "initiation", "of", "DNA", "repl...

PMC11782508

The FTIR spectrum was recorded at room temperature in the mid-infrared region (400–4000 cm⁻¹).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "FTIR", "spectrum", "was", "recorded", "at", ...

PMC11564322

It should be noted that the effect of EDPs depends on the concentration, form of administration, exposure time, and tissue.

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PMC5941560

Short and long insertions and deletions were defined using a cutoff of 50 bp, in accordance with the structural variant databases from NCBI .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC7185206

Further, sPD-L1 derived from a subset of tumor cells may protect distant malignant cells from anti-tumor immunity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", ",", "sPD-L1", "derived", "f...

PMC11297139

Lastly, DNA was purified using MinElute PCR Purification Kit (QIAGEN).

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PMC11144200

The long-term viability of adaptive effector T cells appears to be necessary for the sustained remission of solid malignancies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "long-term", "viability", "...

PMC10538569

stands for P values = or < 0.001. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "stands", "for", "P", "values", "=", "or", "<", "0.001", ".", "(" ] } ]

PMC9681981

Then, the cells were cultured in 24-well plates.

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PMC11171319

In fact, we isolated HCMV clinical strains in our laboratory, namely HCMV-DB and BL, which fully replicate in human mammary epithelial cells (HMECs), ovarian epithelial cells (OECs), prostate epithelial cells (PECs), and astrocytes followed by their transformation with the appearance in cultures of CMV-transformed HMEC...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-...

PMC9429973

Our study concerned patients diagnosed with COVID-19 during this period.

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PMC6133382

GNA does not require Ca or Mg cofactors to bind, allowing the use of 10 μM EDTA to ameliorate cell clumping during repeated centrifugation and wash steps.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11803210

MCF-7 cells were treated with vehicle control (0.1 % DMSO) or 10 µM naringenin for 24 hours, then total RNA was isolated from samples for sequencing.

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PMC11627133

Quantification of SpyRho fluorescence intensities (mean±s.d.,

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "SpyRho", "fluorescence", "intensities", "(", "mean±s.d", ".", "," ] } ]

PMC9429973

The estimated 1 year PFS was 68.5%(95%CI 21.3% to 92.2%).

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PMC9429973

No patient discontinued asciminib solely due to intolerance.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "patient", "discontinued", "asciminib", "solely", "due", "to", "intolerance", "." ] } ]

PMC10114490

Orange: NES > 0, enriched in diHLC-T. Blue: NES < 0, enriched in iHDF-T. Red line marks FDR = 0.05.

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PMC6461034

The arrow indicates MET, a receptor tyrosine kinase that is in the INKA top 20 for CRC0254, but not CRC0177.Scheme indicating signal transduction pathways of IGF1R/INSR, EGFR, ERBB2, EPHA2, and MET.

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PMC11697703

For miR193b-miR-365 GoF experiments, we confirmed that co-electroporated miR193b-miR-365 constructs were co-expressed in neurons (Figure S2A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "miR193b-miR-365", "GoF", "...

PMC6160470

Calcein accumulation should not be affected by compounds that alter mitochondrial or plasma membrane potential, as compared to Rho123, which is a positively charged molecule.

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PMC9429973

Cox proportional hazards model was used for multivariate analysis.

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PMC7452526

It has a high capacity of reducing the cell viability percentage lower than 10%.

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PMC9473868

These results indicated BAI could induce SW982 cells apoptosis.

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PMC10975211

Future clinical trials will be crucial in assessing the safety and efficacy in human subjects.

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PMC11046454

Structures of aptamer-functionalized CAR.

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PMC11216402

Variation in the chromatin accessibility profiles across GC cell lines is consistent with differential TF activity inferred from sequence-based machine learning. (

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PMC10772747

For experiments, T47D cells were used at 80-90% confluence (Amalina et al., 2023).

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PMC11488203

Data represent the mean ± s.d. (

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PMC8916024

In our study, Proteobacteria as identified as one of the main bacterial phyla in sediment, which was consistent with a previous report that Proteobacteria was the most abundant flora in rice field sediment (Chen et al., 2012; Zhao et al., 2017).

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PMC9429973

The products of BCL2 and its homologues, including BAX and BCL2-like 12 (BCL2L12), are implicated in CLL, as apoptosis regulators.

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PMC8358006

The biological associations with H3K27me3 dysregulation may be attributed to the function of the tissue and the pathophysiological status of the model in relation to the ongoing gene expression programs.

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PMC11704135

By chelating these ions, the derivatives prevent their participation in Fenton and Haber-Weiss reactions, which generate highly reactive hydroxyl radicals.

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PMC9429973

Sometimes the language used by reporters reflects the uncertainty in the diagnosis due to atypical appearances or other tests not being consistent, the fact that tests are incomplete or clinical information is missing from the referral.

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PMC11519583

These findings indicated that Wnt5b and Wnt11 synergistically contribute to excessive MP proliferation and IMAT accumulation.

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PMC11422497

Histological changes, Ki-67 staining, and TUNEL assay were performed on the subcutaneous tumor tissues to comprehensively examine the impact of circRNA on GISTs cells.

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PMC11285179

Enrichment analysis of gene pathways showed that RA signaling pathways were activated after CCL28 stimulation (Fig. 4A).

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PMC10114490

A complete list of differentially expressed genes is included in Additional file 2: Table S4.

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PMC3888431

Nowadays, related CHO cells are the most commonly used cell lines in modern research and biotechnology .

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PMC11411004

To detect the active HDAC isoforms, 2 μM I-4 was applied to CHO-ADM monoclonal antibody cells.

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PMC11794588

Ten phototropic nauplii were introduced to each container and cultured for 24 h at room temperature.

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PMC9429973

Results: We identified six patients with monoallelic germline IKZF2 mutations (one nonsense (p.

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PMC11739504

These results establish a link between acetylation regulated by Kat2b and its relevance to ciliary assembly and function.

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PMC11471157

The hydrolysate was then derivatized using the AccQ-Tag Ultra Derivatization Kit (Waters, MA, USA), and the derivatives were analyzed via pre-column derivatization HPLC.

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PMC11700165

Graphic representation of the kinases investigated. (

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PMC11792888

In this work, we evaluate the effects of R. junceus venom on cell viability in non-cancerous and cancerous NSCLC cell lines using cell viability assays, flow cytometry, and Western blot.

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PMC11451940

Moreover, the following human carcinoma cells were also used for studies with 24 h incubation time: cisplatin-resistant ovarian carcinoma (A2780R), breast adenocarcinoma (MCF-7), prostate adenocarcinoma (PC-3), lung adenocarcinoma (A549) and bone osteosarcoma (HOS), which were obtained from ATCC collection of cell line...

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PMC11265931

In conclusion, the evidence provided here clearly suggests that garlic SEVs have therapeutic potential on cancer cells while having no cytotoxic effect on the healthy cell line HUVEC.

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PMC11317131

We observed evolved libraries increase efficiency by 15.4, 70.2 and 20.9-fold over P1, P2 and P3, respectively (Figure 3B).

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PMC11670954

Furthermore, a separate study demonstrated that LPS increases the mRNA expression of RhoA , ROCK2 , and MLCK , leading to alterations in their distribution within Caco2 cells.

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PMC11506670

Lastly, cell fusion—a result of aberrant mitosis sometimes observed in some malignancies —can be observed in cells transfected with NRAS E37K.

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PMC9429973

However, with the average age of AML diagnosis being approximately 70 years, many AML patients are ineligible to receive IC.

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PMC8540611

In the following, only AuNP14 and AuNP15 effects on the HL-60 and CEM-SS cell lines will be considered since AuNP13 affected the target siRNA in any case, and there was no effect from the use of the target siRNA for HeLa cells.

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PMC10940855

Right, mean levels of total Annexin V cells within each treatment group.

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PMC11680578

Synergistic treatment of paclitaxel (PTX) and rosiglitazone (RGZ) on the cell cycle of SKOV-3 ovarian cancer cells. (

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PMC5035325

Animal’s procedures were performed in accordance with the guidelines stipulated by Animal Subject Committee Review Board of the CIM and CIM”s Institutional Animal Care and Use Committees.

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PMC9429973

This result suggests that part of the resistance mechanism is transcriptionally mediated and virtually common to several SI.

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PMC11323699

Considering the therapeutic relevance of targeting the CD47/TSP-1 axis, we used the CD47-derived TAX2 peptide to selectively antagonize it in a preclinical model of aggressive ovarian carcinoma.

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PMC11506827

The cells (2.5 × 10 cells/well in 60-mm dishes) were seeded and allowed to adhere overnight before pre-treating with GEF or DMSO for 12 h in a serum-free medium.

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PMC4005030

Salvia miltiorrhiza has long been used in the traditional Chinese formulations for the treatment of heart ischemic diseases.

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PMC11352666

Moreover, MERTK inhibition may be particularly effective in combination with chemotherapy and targeted agents .

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PMC11787651

The microflow system provided stable and reproducible retention time information comparable to results from the nanoflow system.

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PMC8956657

The IMPα3 is shown in dark gray and surface mode, and the p50 is shown in orange in stick mode.

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PMC4816271

The plate was centrifuged at 1000g for 40 minutes at RT.

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PMC9786247

Neither of the strains induced detectable IL-1β, IL-6 and TNF-α host cell responses at 1 d p.i. (

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PMC11637276

Collagen I was dissolved in ice-cold PBS to a final concentration of 1 mg/ml, and 100 μl of the solution was used to coat a 35 mm glass-bottom dish with the help of a pipette tip.

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PMC11128598

The cell line A-172 was the one with the lowest CI (0.06), despite of using lower CQ doses than in the rest of the cell lines assayed.

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PMC11706491

To assess the impact of conditional Sty1 inactivation, we analyzed asynchronous cultures of wild-type and sty1-as strains treated with 3-MB-PP1.

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PMC7185206

In our Cox proportional hazards models, low PD-L1 protein-to-mRNA ratios predict strikingly poor outcomes in papillary renal cell carcinoma (Figure 1(c)).

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PMC11243198

These findings further support the inhibitory activity of the GANT61 analogs on the Hh pathway.

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PMC10545062

It is worth noting that two outlier animals were observed.

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PMC11740907

Another peak was shown at 907.60 cm in region of fingerprint due to bending type vibrations at W=O. Very strong and broad W-O-W stretch pattern at 732.42 cm was observed.46 BW showed C-O stretch in fingerprint region at 1377.25cm and an intense peak was also noticed at 659.73 cm because of bending vibrations.

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PMC10994876

This process plays a crucial role in YAP-induced cell proliferation and growth promotion.

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PMC3203927

These results are supportive of further cytokine identification and validation studies with cells from non-neural tissue.

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PMC9352806

Saponins from bitter melon (BMS) are well-known to have various biological activities, especially in the field of fat-lowering.

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PMC9429973

The proportion of patients on ruxolitinib (rux) with a negative or borderline response after two doses was higher than observed in other patients (5/10 vs 5/47, p=0.01).

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PMC9429973

The majority of pts (71/86 (83%)) had IPI score 3-5.

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PMC10135767

These findings provide new insights into the mechano-chemical regulation mechanism for adhesion molecule-mediated intracellular signaling pathways, providing a basis for the development of novel concepts in risk assessment, clinical diagnosis, and the effectiveness of inflammatory disease and cancer treatment.

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PMC11806106

Nevertheless, the kinetics displayed a general alignment in comparable ranges, reinforcing our findings that the full agonist DAMGO elicits activation of the MOR at a notably faster rate compared to the partial agonist morphine (sensor: 75× faster, receptor:G-protein interaction: 20x faster).Fig.

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PMC7723249

Polarization of human epithelial cells leads to a different pattern of surface proteins on the apical side compared to the basolateral side.

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PMC9776316

Consistent with the decreased cell viability, the IC50 of cisplatin in the XRCC4 knockdown cells was also significantly lower than in the control cells (Figure 2c).

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PMC11438317

Thus, interactions of these proteins, which are critical for T cell activation and are dependent on tyrosine phosphorylation, seem to be regulated by LYP, which rather than targeting a particular protein, dephosphorylates several adaptor proteins that are part of the microclusters.

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PMC6461034

Other kinases, including AKT2, RPS6KB1, and RET, showed similar behavior.

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PMC11594074

In these cells, the reporter genes were controlled by a cytomegalovirus (CMV) promoter, which is sensitive to the methylation status .

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PMC11185260

ImageJ software was used to calculate tumor volumes.

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PMC10877303

In the P1 position of the substrate, the glutamine (Q) residue is essential, while the P2 position strongly prefers a leucine residue .

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PMC9910796

H-K) Immuno-EM of ER-associated zippers with antibodies to luminal ER marker PDI (H), pp220 (I), pp62 (J) and pEP84R (K).

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PMC11635087

Isolated chloroplasts are enclosed by a double envelope membrane and have multiple layers of thylakoid membranes, which do not form grana stacks in the chloroplasts of land plants (Fig. 5C).

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PMC11240571

Male BALB/c nude mice (8 weeks old) were purchased from Clair (Tokyo, Japan) to establish the xenograft model.

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PMC11791264

A, SKOV3 cells were stably transfected with control vector (pCDH) or pCDH-SETD7 in the absence or presence of bafilomycin A1 (Baf A1, 100 nM) for 10 h. The lysates were immunoblotted with the antibodies indicated on the right.

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PMC11706776

Reverse Transcription (RT) was performed from 1 µg of RNA with the “Maxima H Minus First Strand cDNA Synthesis Kit” (Macherey-Nagel).

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PMC9429973

AM-exposed AdCAR-T were co-cultured with OCI-AML-3 (21 d vs 7 d AM exposure, followed by 7 d AM absence).

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