OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9895440	and/or anti-CD28 (CD28.2, Biolegend Cat Nr.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "and/or", "anti-CD28", "(", "CD28.2", ",", "Biolegend", "Cat", "Nr", "." ] } ]
PMC11461874	To monitor the bioluminescence, cells were cultured in the recording medium [phenol-red free DMEM (Sigma Aldrich) supplemented with 10% fetal bovine serum (Equitech Bio, Inc.), 3.5 mg/mL glucose, 25 U/mL penicillin, 25 mg/mL streptomycin, 0.1 mM luciferin, and 10 mM HEPES-NaOH; pH 7.0].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10203589	Knockdown or overexpression of FGF18 in human non-small cell lung cancer cell A549 significantly reversed the effects of HDACs on the proliferation, migration and cell cycle of lung cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	First, we derive the Karush–Kuhn–Tucker (KKT) conditions for MSMNTF (necessary conditions for a solution in nonlinear programming to be optimal):2[12pt] $$ _i \,( }GS_i + A_iGS_i^}} ) + 2( }GS_i^} + GS_i^}G^}GS_i} )} ) - = 0,$$∑i-2AiTGSi+AiGSiT+2GSiGTGSiT+GSiTGTGSi-β=0,3[12pt] $$G^}A_iG - G^}GA_iG^}G = 0,$$-GTGAiGTG=0,...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11344246	In order to biologically validate our bioinformatic methods, five proteins were knocked down in both MOC cell lines and fibroblasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "order", "to...
PMC11218145	To evoke the Ca release from the ER and the consequent uptake in the mitochondria and cytosol, cells were stimulated with 1 µM Bradykinin (BK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	On cardiovascular examination, signs of right and global heart failure were found in respectively 50% and 15% of the cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", ...
PMC11756937	Afterwards, the cells were enzymatically dissociated, triturated to achieve single-cell suspension, centrifuged and stained for stage-specific embryonic antigen 4 (SSEA4) which is expressed on the surface of undifferentiated hiPSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684297	After image capturing, the cells were processed for MTT assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "image", "capturing", ",", "the", "cells", "were", "processed", "for", "MTT",...
PMC9429973	Aims: The Phase 2 results support continued study of imetelstat 9.4 mg/kg in a Phase 3 randomized controlled study, for which the study design is described here.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11732523	Upon admission, her vital signs were: temperature 36.8 °C, heart rate 70 bpm, respiratory rate 22 bpm, blood pressure 124/82 mmHg, and oxygen saturation 85 % on room air.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9622879	As the conventional retail market is not suitable for the LEM, a new market has been studied in many previous studies to coordinate prosumers efficiently.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC2193049	The cells were then lysed in 1 ml lysis buffer (1% Triton X-100, 0.15 M NaCl, 5 mM EDTA, 20 mM Tris–HCl [pH 7.3], and 0.2 mg/ml phenylmethylsulfonyl fluoride) and maintained on ice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11337594	The cleavage of PARP1, CASP7, CASP3, and GSDME induced by TER was significantly reduced in p53 knockout cells (Fig. 2E), and apoptosis was also diminished (Fig. 2F and G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10237474	Enhancers 1 and 2 were added to cells 20 h post transfection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enhancers", "1", "and", "2", "were", "added", "to", "cells", "20", "h", ...
PMC9429973	The CAR-T cells were enriched using biotinylated anti-EGFR mAb and further expanded with anti-CD3/CD28 beads or gamma-irradiated EBV-LCL cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CAR-T", "cells", "were", ...
PMC9622879	The UDDSR program collected flexible bids from the homes, including information of their controllable appliances.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "UDDSR", "program", "collected", "flexible", "bi...
PMC11761919	The rabbit anti-Fiber2 polyclonal antibody (Jia et al., 2022) was used in western blot detection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "rabbit", "anti-Fiber2", "polyclonal",...
PMC5600151	All these modifications may decrease the cytotoxicity and enhance the transfection efficiency to a different extent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "these", "modifications", "may", "decrease", "th...
PMC11449273	Beads were centrifuged at 21,000 x g for 1 min and supernatants were aspirated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Beads", "were", "centrifuged", "at", "21,000", "x", "g", "for", ...
PMC11615101	The hind paw volume was measured weekly from days 1 to 28, and a representative image taken on day 28 is shown in figure (Figure 7A, upper panel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11653533	Ficus exasperata, also known as Ficus asperrima Roxb, Ficus hispisdissima, Ficus politoria Moon, Ficus punctifera Warb.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ficus", "exasperata", ...
PMC9429973	We extracted data on age, sex, and complete blood count and white blood cell differential (CBC) at the time of testing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11342785	Inspired by these models, we hypothesized that we could synthetically drive TPPP MT bundling in cells by directly connecting it to synthetic droplet-forming hubs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11738017	Figure created with BioRender.com. (	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "created", "with", "BioRender.com", ".", "(" ] } ]
PMC10578720	In particular, liver macrophages of DCA-treated mice secreted more IL-1β and less IL-10 than vehicle-treated mice (Figure 7F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "particular", ...
PMC3730428	We therefore conclude that cotreatment with SAHA (or a similar HDAC inhibitor) and a SMC could be a promising therapeutic approach for the treatment of mesothelioma that will exploit the TNFα-rich, pro-inflammatory micro-environment to induce apoptosis via TNFR1 complex IIb (Figure 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9895440	Sequencing was performed on Illumina Novaseq 6000 platform to produce paired-end 101nt R2 reads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sequencing", "was", "performed", "on", "Illumina", "Novaseq", "6000", ...
PMC11762280	To establish an acute UVB injury model, mice were exposed to low-dose (215 mJ/cm) or high-dose (430 mJ/cm) of UVB by UVB lamps (Philips, UVB Broadband PL-S 9 W/12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11490153	For the comparison of IC50 values, the upper and lower confidence limits were compared against each other.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "comparison", "of", "IC50...
PMC10237474	We first generated both CHO-K1 and Expi293F GnTI stable pools after co-transfecting the PB transposase with two expression vectors, encoding chain A or B linked with an Fc-CPM monomer.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Given the confounding effect of unbalanced pt characteristics between the IA and Lo + VEN cohorts, we performed a multivariate analysis on the full population (n=635) taking into consideration the effects of age, treatment intensity, MRD status, and ELN category on OS and RFS (all significant by univariate analysis).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10734950	The cytotoxicity compound F8 was assessed on the CCRF-CEM cell line through a DNS live-cell bioimaging assay .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cytotoxicity", "compound", "F8", ...
PMC4355729	Interestingly, spindle-shaped morphology of mesenchymal cells has been observed in cells with the down-expression of PIK3R1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "spindle-shaped", "morphology", ...
PMC11409031	This enables accurate prediction of responses to immune therapy and chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "enables", "accurate", "prediction", "of", "responses", "to", "immune", "therapy", ...
PMC9954564	Finally, it presents all significant genetic interactions and the best one.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "it", "presents", "all", "significant", "genetic", "interactions", ...
PMC11201989	Moreover, PD-L1 formed a complex with PC-2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "PD-L1", "formed", "a", "complex", "with", "PC-2", "." ] } ]
PMC7887261	As shown in Table 2, of the 24 candidate genes, the most evolutionarily constrained (intolerance) genes with the lowest LoF observed/expected (o/e) values were PHF13, TP63, and STAU2; whereas the genes with the highest LC-correlated PhoRank scores were CHEK2, ATM, TP63, and MME.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10237474	Proteins 9 and 10 co-produced from CHO-K1 showed two bands in SDS-PAGE with each corresponding to an individual chain in the complex (Fig 6A and 6B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: EZH2 and PIK3IP1 mRNA level was examined by qPCR in newly-diagnosed AML patients and healthy control from Feb. 1, 2016, to Jan. 30, 2022, at our institute with approval of the Ethics Committee.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11766174	In the experiment presented in Figure 4A, three subgroups of CA-positive cells were arbitrarily defined as strong, moderate, and weak, accounting for average percentages of 8.6, 12.9, and 54.7 of the total CA-positive cells (~76% as described above), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In this scenario, real-world studies present an essential role on complementing efficacy and safety data from pivotal and randomized studies in a much broader population profile.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11576293	4H, Ar-H), 7.69 (s, 1H, pyrimidine–C5-H), 7.5 (d., 2H, Ar-H, J = 9 Hz), 7.04 (d., 2H, Ar-H, J = 9 Hz), 3.92 (s, 3H, OCH3), 2.73 (s, 3H, SCH3); C NMR (75 MHz, CDCl3) δ (ppm) = 172.7, 164.3, 163.14, 162.17, 136.9, 135.5, 129.1, 128.8, 128.5, 114.3, 106.7, 55.5, 14.4; HRMS (ESI+) calcd.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401358	ATR-FTIR spectra showed that the content of the β-sheet structure in SF-95 °C group reached as high as 60 %, more than twice that without heating, and could be oxidized into random coil and α-helix structures (Fig. 6C and Fig. S19B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10669128	They also showed the model effectiveness for the study of KIT pathway activation, GIST pathogenesis, and preclinical validation of GIST therapies and drug response .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11321678	For low volume, use a 40 µm Flowmi Cell Strainer (H13680‐0040, Bel‐Art) to minimize volume loss.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "low", "volume", ...
PMC11528603	SA-EA-exposed cells exhibited early noticeable morphological changes (i.e., at 24-hour time point) including elongation, shrinkage, and blebbing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SA-EA-exposed", ...
PMC11745823	Ns, no significant difference.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ns", ",", "no", "significant", "difference", "." ] } ]
PMC9429973	There was no significant different in FLT3-ITD positivity between FL cohort with or without FLT3-i (p=0.3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "no", "significant", "d...
PMC10745221	15 μL of the non-histone supernatant and non-histone pellet were loaded into each well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "15", "μL", "of", "the", "non-histone", "supernatant", "and", "no...
PMC11078693	Pick up the glass with forceps/tweezers (Figure 1, problem 2).e.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pick", "up", "the", "glass", "with", "forceps/tweezers", "(", "Figure", "1", ...
PMC11547972	Its anti-cancer effects have been demonstrated on a panel of human tumor cell lines, including bladder, lung, breast, and colon cancer cells, by modulating epigenetic as well as non-epigenetic pathways involving interactions with the Akt/MAPK and the Nrf2/ARE signaling pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743414	Studies involving the knockout and overexpression of the FHL1 gene have indicated that elevated FHL1 expression is associated with poor clinical outcomes in AML patients undergoing induction chemotherapy with cytarabine and daunorubicin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7053076	BGD is usually considered a universal inhibitor of both NF-κB pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BGD", "is", "usually", "considered", "a", "universal", "inhibitor", "of", "both", "NF...
PMC9436459	Scheme 11Enantioselective total synthesis of brosimone A (80) by the Lei group Enantioselective total synthesis of brosimone A (80) by the Lei group In 2021, the Tang group reported a convergent route towards the total synthesis of two MDAAs named kuwanons G and H (92 and 93) with unique dehydroprenylflavone dienes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11437637	Shake and mix the suspended cells thoroughly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shake", "and", "mix", "the", "suspended", "cells", "thoroughly", "." ] } ]
PMC9429973	Aims: The aims of the monocentric study, named MAS_PED1, that was approved by Ethics Committee, are to: a) identify patients (pts) with different cutaneous forms at risk of developing aggressive systemic disease; b) detect the known KIT D816V mutation using RT-PCR; c) identify different KIT, and/or additional gene muta...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9341513	Beyond the loss of interactions with the insert itself, the main effect of removing the insert is an increase in interactions between CCND1 and upstream DHSs, consistent with their reduced genomic separation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615101	The top layer was aspirated, mixed with chilled isopropanol, and incubated on ice (10min), followed by centrifugation (15min at 11,000 × g at 4°C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10899471	However, neither the mimic nor the inhibitor of miR-455-5p could regulate BATF2 expression ( Figures 2H–K ), suggesting that BATF2 expression was repressed by miR-939-3p in sarcoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11694066	We calculated normalized AUC Z-scores from dose–response survival curves of each drug in the JN1 cell line (Supplementary Table S3) and compared them with those of a panel of 92 tumor cell lines previously screened with the same library (Supplementary Table S4; ref.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706297	Initially, chalcones (A1 and A2) were afforded via Claisen–Schmidt condensation of ketones (1-(2-methoxynaphthalen-1-yl)ethan-1-one and 1-(naphthalen-2-yl)ethan-1-one) and 4-chlorobenzaldehyde.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC3813807	Total RNA was extracted using an E.Z.N.A. FFPE RNA isolation kit (Omega Bio-Tek, Inc., Norcross, GA, USA), according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7192625	The black line shows the diagonal (x = y). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "black", "line", "shows", "the", "diagonal", "(", "x", "=", "y", ...
PMC11377827	n = 4 biological replicates, mean ± sd.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "4", "biological", "replicates", ",", "mean", "±", "sd", "." ] } ]
PMC11711127	Indeed, the pTreg and Th17 lineage are inherently connected by TGF-β mediation and as discussed, FOXP3 expression is considered unstable in pTreg populations (131).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11541409	Although 2DG (IC50 0.5–2.5 µM) inhibited the proliferation of imatinib-resistant GIST cells in vitro, it had limited inhibitory effects in vivo, possibly due to insufficient drug concentration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4277423	While CCR5 expression was reduced in the CCR5/CR2 cells, no significant difference in CD4 and CXCR4 expression (Fig. 5D) and in cell growth (Fig. 5E) was found in CCR5/CR2 cells as compared to mock-transduced and CCR5/GF1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11323699	2Immunohistochemical assessment of CD47 expression in ovarian carcinomas at diagnosis and after neoadjuvant chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2Immunohistochemical", "assessment", "of", "CD47", "expression", "in", ...
PMC9918897	Although XN is present in significant amounts in hops, its concentration decreases markedly during brewing, despite numerous initiatives to increase the natural amount of XN in beer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791264	The Tubulin panel is reused from Figure 1K as both panels originate from the same experimental blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Tubulin", "panel", "is", "reuse...
PMC11342785	The chamber was then filled with the solution and sealed, then imaged by using TIRF microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "chamber", "was", "then", "filled", "...
PMC10988808	Gene expression differential analysis was conducted utilizing the 'limma' R package, employing an adjusted p-value of < 0.05 as the selection threshold.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11701801	Moreover, simultaneous depletion of both paralogs in SMARCA4/SMARCA2-deficient cells and SS18–SSX fusion cells (Fig. 2C; Supplementary Fig. S2A and S2B) led to significantly greater growth suppression than depletion of either paralog alone (Fig. 2D); however, single or dual depletion of CREBBP and EP300 (Fig. 2C; Suppl...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721064	Consistent with previous reports , we employed a dispase-enzyme and collagenase extraction method to obtain LNCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consistent", "with", "previous", "reports", ",", "we",...
PMC10671321	The amplitude of the decrement was 26% between the 1st and 5th stimulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "amplitude", "of", "the", "decrement", "was", "26", "%", ...
PMC9105697	Sequencing costs are constantly decreasing and exome sequencing is increasingly performed in routine treatment of sarcoma patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sequencing", "costs", "are", "constantly", "decre...
PMC9429973	Methods: This is a retrospective cohort encompassing newly diagnosed AML adult patients (pts) treated at Instituto do Cancer do Estado de Sao Paulo, Brazil, between June 2011 and June 2020.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11470381	Experimental setup and analysis were used for figures 6D, E, and figure 6 – figure supplement 1B and C. General notes Nucleofection often leads to significant cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267830	g The knockdown of THOC1 affected cell colony formation and proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "The", "knockdown", "of", "THOC1", "affected", "cell", "colony", "formation", "an...
PMC8097906	The images were taken via the software CellSens Entry (Olympus, Tokyo, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "images", "were", "taken", "via", "the", "...
PMC11635519	MCP1 did not activate the CCR2 receptor when the peptide was not fused to the signal sequence and GPI-AP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MCP1", "did", "not", "activate", ...
PMC9261184	The effect of engine load on slip is more pronounced for the LDPF four-stroke engines (generators) than for the LPDF two-stroke (main) engines, which exhibit a flatter load profile.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The other main pathway is that of autophagy and lysosomal degradation, eliminating protein aggregates and damaged organelles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "other", "main", "pathway", "is"...
PMC11612794	DNA was stained with DAPI.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "DNA", "was", "stained", "with", "DAPI", "." ] } ]
PMC11769516	It seems that it occurs inside the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "seems", "that", "it", "occurs", "inside", "the", "cells", "." ] } ]
PMC11720808	Stable TLR4-overexpressing 143B cells and wild-type 143B cells were treated with DMSO or SCU, and colony formation assay was performed to investigate the effect of TLR4 overexpression and SCU treatment on 143B cell proliferation. (	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11279397	Thymol exhibited antiviral activity by effectively binding to the receptor of SARS-CoV-2 spike glycoprotein S1 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thymol", "exhibited", "antiviral", "activity", "by", "effectively...
PMC11024707	After controlling for age and sex, the differences between groups were disappeared.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "controlling", "for", "age", "and", "sex", ",", "the", "diffe...
PMC11657744	P < 0.05; , P < 0.01; *, P < 0.001. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", ";", "*", ...
PMC11247842	Four variants (rs133257289 in liver, rs137491588 in uterus, rs135442643 in blood, rs135443540 in mammary) that were identified as cis-eQTL for DGAT1 on BTA14 were also associated with CM (see Additional file 1: Table S10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11155445	Thus, the emission band of derivative (68ab) red-shifted up to 7 nm having Br as compared to the chlorine containing derivative (68aa).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	E, schematic depicting strategy for systematically varying the microtubule-interaction component (TPPP variant) of an inducible synMAP TPPP-IDR circuit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", ",", "schemat...
PMC11180402	The most common type of BC is non-muscle invasive bladder cancer (NMIBC), which accounts for 75% of newly diagnosed BC; MIBC accounts for 25% of all new diagnoses .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11633763	DUB has recently emerged as a possible target for numerous tumour therapies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DUB", "has", "recently", "emerged", "as", "a", "possible", "target", "for", ...
PMC6684588	These findings indicate that endogenous follistatin exerts an important regulatory influence on Smad2/3 pathway signaling in adult muscle under both normal and pathologic conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9027909	The study was approved by the ethics committee/institutional review board of the Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379	Results showed a significant consensus of down-regulation of genes involved in extracellular matrix organization, locomotion and cell adhesion in progeny cells compared to the parental HEK293 strain (Fig. 3a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC6835428	The diameter of lacuna aperture is 1.8–6 μm in most animal species, and 3.2–3.6 μm in humans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "diameter", "of", "lacuna", "ape...
PMC11711663	RCVL1 and RCVL2, referred to as “re-substitution CVL”, establish an upper bound for the variation in the CVL value caused by random cross-validation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9895440

and/or anti-CD28 (CD28.2, Biolegend Cat Nr.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "and/or", "anti-CD28", "(", "CD28.2", ",", "Biolegend", "Cat", "Nr", "." ] } ]

PMC11461874

To monitor the bioluminescence, cells were cultured in the recording medium [phenol-red free DMEM (Sigma Aldrich) supplemented with 10% fetal bovine serum (Equitech Bio, Inc.), 3.5 mg/mL glucose, 25 U/mL penicillin, 25 mg/mL streptomycin, 0.1 mM luciferin, and 10 mM HEPES-NaOH; pH 7.0].

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10203589

Knockdown or overexpression of FGF18 in human non-small cell lung cancer cell A549 significantly reversed the effects of HDACs on the proliferation, migration and cell cycle of lung cancer cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6379402

First, we derive the Karush–Kuhn–Tucker (KKT) conditions for MSMNTF (necessary conditions for a solution in nonlinear programming to be optimal):2[12pt] $$ _i \,( }GS_i + A_iGS_i^}} ) + 2( }GS_i^} + GS_i^}G^}GS_i} )} ) - = 0,$$∑i-2AiTGSi+AiGSiT+2GSiGTGSiT+GSiTGTGSi-β=0,3[12pt] $$G^}A_iG - G^}GA_iG^}G = 0,$$-GTGAiGTG=0,...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11344246

In order to biologically validate our bioinformatic methods, five proteins were knocked down in both MOC cell lines and fibroblasts.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "order", "to...

PMC11218145

To evoke the Ca release from the ER and the consequent uptake in the mitochondria and cytosol, cells were stimulated with 1 µM Bradykinin (BK).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

On cardiovascular examination, signs of right and global heart failure were found in respectively 50% and 15% of the cases.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", ...

PMC11756937

Afterwards, the cells were enzymatically dissociated, triturated to achieve single-cell suspension, centrifuged and stained for stage-specific embryonic antigen 4 (SSEA4) which is expressed on the surface of undifferentiated hiPSCs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11684297

After image capturing, the cells were processed for MTT assay.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "image", "capturing", ",", "the", "cells", "were", "processed", "for", "MTT",...

PMC9429973

Aims: The Phase 2 results support continued study of imetelstat 9.4 mg/kg in a Phase 3 randomized controlled study, for which the study design is described here.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11732523

Upon admission, her vital signs were: temperature 36.8 °C, heart rate 70 bpm, respiratory rate 22 bpm, blood pressure 124/82 mmHg, and oxygen saturation 85 % on room air.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9622879

As the conventional retail market is not suitable for the LEM, a new market has been studied in many previous studies to coordinate prosumers efficiently.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC2193049

The cells were then lysed in 1 ml lysis buffer (1% Triton X-100, 0.15 M NaCl, 5 mM EDTA, 20 mM Tris–HCl [pH 7.3], and 0.2 mg/ml phenylmethylsulfonyl fluoride) and maintained on ice.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11337594

The cleavage of PARP1, CASP7, CASP3, and GSDME induced by TER was significantly reduced in p53 knockout cells (Fig. 2E), and apoptosis was also diminished (Fig. 2F and G).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10237474

Enhancers 1 and 2 were added to cells 20 h post transfection.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enhancers", "1", "and", "2", "were", "added", "to", "cells", "20", "h", ...

PMC9429973

The CAR-T cells were enriched using biotinylated anti-EGFR mAb and further expanded with anti-CD3/CD28 beads or gamma-irradiated EBV-LCL cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CAR-T", "cells", "were", ...

PMC9622879

The UDDSR program collected flexible bids from the homes, including information of their controllable appliances.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "UDDSR", "program", "collected", "flexible", "bi...

PMC11761919

The rabbit anti-Fiber2 polyclonal antibody (Jia et al., 2022) was used in western blot detection.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "rabbit", "anti-Fiber2", "polyclonal",...

PMC5600151

All these modifications may decrease the cytotoxicity and enhance the transfection efficiency to a different extent.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "these", "modifications", "may", "decrease", "th...

PMC11449273

Beads were centrifuged at 21,000 x g for 1 min and supernatants were aspirated.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Beads", "were", "centrifuged", "at", "21,000", "x", "g", "for", ...

PMC11615101

The hind paw volume was measured weekly from days 1 to 28, and a representative image taken on day 28 is shown in figure (Figure 7A, upper panel).

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PMC11653533

Ficus exasperata, also known as Ficus asperrima Roxb, Ficus hispisdissima, Ficus politoria Moon, Ficus punctifera Warb.,

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PMC9429973

We extracted data on age, sex, and complete blood count and white blood cell differential (CBC) at the time of testing.

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PMC11342785

Inspired by these models, we hypothesized that we could synthetically drive TPPP MT bundling in cells by directly connecting it to synthetic droplet-forming hubs.

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PMC11738017

Figure created with BioRender.com. (

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PMC10578720

In particular, liver macrophages of DCA-treated mice secreted more IL-1β and less IL-10 than vehicle-treated mice (Figure 7F).

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PMC3730428

We therefore conclude that cotreatment with SAHA (or a similar HDAC inhibitor) and a SMC could be a promising therapeutic approach for the treatment of mesothelioma that will exploit the TNFα-rich, pro-inflammatory micro-environment to induce apoptosis via TNFR1 complex IIb (Figure 8).

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PMC9895440

Sequencing was performed on Illumina Novaseq 6000 platform to produce paired-end 101nt R2 reads.

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PMC11762280

To establish an acute UVB injury model, mice were exposed to low-dose (215 mJ/cm) or high-dose (430 mJ/cm) of UVB by UVB lamps (Philips, UVB Broadband PL-S 9 W/12).

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PMC11490153

For the comparison of IC50 values, the upper and lower confidence limits were compared against each other.

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PMC10237474

We first generated both CHO-K1 and Expi293F GnTI stable pools after co-transfecting the PB transposase with two expression vectors, encoding chain A or B linked with an Fc-CPM monomer.

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PMC9429973

Given the confounding effect of unbalanced pt characteristics between the IA and Lo + VEN cohorts, we performed a multivariate analysis on the full population (n=635) taking into consideration the effects of age, treatment intensity, MRD status, and ELN category on OS and RFS (all significant by univariate analysis).

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PMC10734950

The cytotoxicity compound F8 was assessed on the CCRF-CEM cell line through a DNS live-cell bioimaging assay .

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PMC4355729

Interestingly, spindle-shaped morphology of mesenchymal cells has been observed in cells with the down-expression of PIK3R1.

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PMC11409031

This enables accurate prediction of responses to immune therapy and chemotherapy.

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PMC9954564

Finally, it presents all significant genetic interactions and the best one.

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PMC11201989

Moreover, PD-L1 formed a complex with PC-2.

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PMC7887261

As shown in Table 2, of the 24 candidate genes, the most evolutionarily constrained (intolerance) genes with the lowest LoF observed/expected (o/e) values were PHF13, TP63, and STAU2; whereas the genes with the highest LC-correlated PhoRank scores were CHEK2, ATM, TP63, and MME.

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PMC10237474

Proteins 9 and 10 co-produced from CHO-K1 showed two bands in SDS-PAGE with each corresponding to an individual chain in the complex (Fig 6A and 6B).

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PMC9429973

Methods: EZH2 and PIK3IP1 mRNA level was examined by qPCR in newly-diagnosed AML patients and healthy control from Feb. 1, 2016, to Jan. 30, 2022, at our institute with approval of the Ethics Committee.

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PMC11766174

In the experiment presented in Figure 4A, three subgroups of CA-positive cells were arbitrarily defined as strong, moderate, and weak, accounting for average percentages of 8.6, 12.9, and 54.7 of the total CA-positive cells (~76% as described above), respectively.

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PMC9429973

In this scenario, real-world studies present an essential role on complementing efficacy and safety data from pivotal and randomized studies in a much broader population profile.

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PMC11576293

4H, Ar-H), 7.69 (s, 1H, pyrimidine–C5-H), 7.5 (d., 2H, Ar-H, J = 9 Hz), 7.04 (d., 2H, Ar-H, J = 9 Hz), 3.92 (s, 3H, OCH3), 2.73 (s, 3H, SCH3); C NMR (75 MHz, CDCl3) δ (ppm) = 172.7, 164.3, 163.14, 162.17, 136.9, 135.5, 129.1, 128.8, 128.5, 114.3, 106.7, 55.5, 14.4; HRMS (ESI+) calcd.

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PMC11401358

ATR-FTIR spectra showed that the content of the β-sheet structure in SF-95 °C group reached as high as 60 %, more than twice that without heating, and could be oxidized into random coil and α-helix structures (Fig. 6C and Fig. S19B).

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PMC10669128

They also showed the model effectiveness for the study of KIT pathway activation, GIST pathogenesis, and preclinical validation of GIST therapies and drug response .

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PMC11321678

For low volume, use a 40 µm Flowmi Cell Strainer (H13680‐0040, Bel‐Art) to minimize volume loss.

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PMC11528603

SA-EA-exposed cells exhibited early noticeable morphological changes (i.e., at 24-hour time point) including elongation, shrinkage, and blebbing.

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PMC11745823

Ns, no significant difference.

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PMC9429973

There was no significant different in FLT3-ITD positivity between FL cohort with or without FLT3-i (p=0.3).

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PMC10745221

15 μL of the non-histone supernatant and non-histone pellet were loaded into each well.

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PMC11078693

Pick up the glass with forceps/tweezers (Figure 1, problem 2).e.

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PMC11547972

Its anti-cancer effects have been demonstrated on a panel of human tumor cell lines, including bladder, lung, breast, and colon cancer cells, by modulating epigenetic as well as non-epigenetic pathways involving interactions with the Akt/MAPK and the Nrf2/ARE signaling pathways .

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PMC11743414

Studies involving the knockout and overexpression of the FHL1 gene have indicated that elevated FHL1 expression is associated with poor clinical outcomes in AML patients undergoing induction chemotherapy with cytarabine and daunorubicin.

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PMC7053076

BGD is usually considered a universal inhibitor of both NF-κB pathways.

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PMC9436459

Scheme 11Enantioselective total synthesis of brosimone A (80) by the Lei group Enantioselective total synthesis of brosimone A (80) by the Lei group In 2021, the Tang group reported a convergent route towards the total synthesis of two MDAAs named kuwanons G and H (92 and 93) with unique dehydroprenylflavone dienes.

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PMC11437637

Shake and mix the suspended cells thoroughly.

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PMC9429973

Aims: The aims of the monocentric study, named MAS_PED1, that was approved by Ethics Committee, are to: a) identify patients (pts) with different cutaneous forms at risk of developing aggressive systemic disease; b) detect the known KIT D816V mutation using RT-PCR; c) identify different KIT, and/or additional gene muta...

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PMC9341513

Beyond the loss of interactions with the insert itself, the main effect of removing the insert is an increase in interactions between CCND1 and upstream DHSs, consistent with their reduced genomic separation.

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PMC11615101

The top layer was aspirated, mixed with chilled isopropanol, and incubated on ice (10min), followed by centrifugation (15min at 11,000 × g at 4°C).

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PMC10899471

However, neither the mimic nor the inhibitor of miR-455-5p could regulate BATF2 expression ( Figures 2H–K ), suggesting that BATF2 expression was repressed by miR-939-3p in sarcoma.

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PMC11694066

We calculated normalized AUC Z-scores from dose–response survival curves of each drug in the JN1 cell line (Supplementary Table S3) and compared them with those of a panel of 92 tumor cell lines previously screened with the same library (Supplementary Table S4; ref.

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PMC11706297

Initially, chalcones (A1 and A2) were afforded via Claisen–Schmidt condensation of ketones (1-(2-methoxynaphthalen-1-yl)ethan-1-one and 1-(naphthalen-2-yl)ethan-1-one) and 4-chlorobenzaldehyde.

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PMC3813807

Total RNA was extracted using an E.Z.N.A. FFPE RNA isolation kit (Omega Bio-Tek, Inc., Norcross, GA, USA), according to the manufacturer’s instructions.

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PMC7192625

The black line shows the diagonal (x = y). (

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PMC11377827

n = 4 biological replicates, mean ± sd.

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PMC11711127

Indeed, the pTreg and Th17 lineage are inherently connected by TGF-β mediation and as discussed, FOXP3 expression is considered unstable in pTreg populations (131).

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PMC11541409

Although 2DG (IC50 0.5–2.5 µM) inhibited the proliferation of imatinib-resistant GIST cells in vitro, it had limited inhibitory effects in vivo, possibly due to insufficient drug concentration .

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PMC4277423

While CCR5 expression was reduced in the CCR5/CR2 cells, no significant difference in CD4 and CXCR4 expression (Fig. 5D) and in cell growth (Fig. 5E) was found in CCR5/CR2 cells as compared to mock-transduced and CCR5/GF1 cells.

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PMC11323699

2Immunohistochemical assessment of CD47 expression in ovarian carcinomas at diagnosis and after neoadjuvant chemotherapy.

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PMC9918897

Although XN is present in significant amounts in hops, its concentration decreases markedly during brewing, despite numerous initiatives to increase the natural amount of XN in beer .

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PMC11791264

The Tubulin panel is reused from Figure 1K as both panels originate from the same experimental blot.

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PMC11342785

The chamber was then filled with the solution and sealed, then imaged by using TIRF microscopy.

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PMC10988808

Gene expression differential analysis was conducted utilizing the 'limma' R package, employing an adjusted p-value of < 0.05 as the selection threshold.

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PMC11701801

Moreover, simultaneous depletion of both paralogs in SMARCA4/SMARCA2-deficient cells and SS18–SSX fusion cells (Fig. 2C; Supplementary Fig. S2A and S2B) led to significantly greater growth suppression than depletion of either paralog alone (Fig. 2D); however, single or dual depletion of CREBBP and EP300 (Fig. 2C; Suppl...

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PMC11721064

Consistent with previous reports , we employed a dispase-enzyme and collagenase extraction method to obtain LNCs.

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PMC10671321

The amplitude of the decrement was 26% between the 1st and 5th stimulation.

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PMC9105697

Sequencing costs are constantly decreasing and exome sequencing is increasingly performed in routine treatment of sarcoma patients.

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PMC9429973

Methods: This is a retrospective cohort encompassing newly diagnosed AML adult patients (pts) treated at Instituto do Cancer do Estado de Sao Paulo, Brazil, between June 2011 and June 2020.

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PMC11470381

Experimental setup and analysis were used for figures 6D, E, and figure 6 – figure supplement 1B and C. General notes Nucleofection often leads to significant cell death.

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PMC11267830

g The knockdown of THOC1 affected cell colony formation and proliferation.

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PMC8097906

The images were taken via the software CellSens Entry (Olympus, Tokyo, Japan).

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PMC11635519

MCP1 did not activate the CCR2 receptor when the peptide was not fused to the signal sequence and GPI-AP.

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PMC9261184

The effect of engine load on slip is more pronounced for the LDPF four-stroke engines (generators) than for the LPDF two-stroke (main) engines, which exhibit a flatter load profile.

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PMC9429973

The other main pathway is that of autophagy and lysosomal degradation, eliminating protein aggregates and damaged organelles.

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PMC11612794

DNA was stained with DAPI.

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PMC11769516

It seems that it occurs inside the cells.

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PMC11720808

Stable TLR4-overexpressing 143B cells and wild-type 143B cells were treated with DMSO or SCU, and colony formation assay was performed to investigate the effect of TLR4 overexpression and SCU treatment on 143B cell proliferation. (

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PMC11279397

Thymol exhibited antiviral activity by effectively binding to the receptor of SARS-CoV-2 spike glycoprotein S1 .

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PMC11024707

After controlling for age and sex, the differences between groups were disappeared.

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PMC11657744

P < 0.05; **, P < 0.01; ***, P < 0.001. (

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PMC11247842

Four variants (rs133257289 in liver, rs137491588 in uterus, rs135442643 in blood, rs135443540 in mammary) that were identified as cis-eQTL for DGAT1 on BTA14 were also associated with CM (see Additional file 1: Table S10).

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PMC11155445

Thus, the emission band of derivative (68ab) red-shifted up to 7 nm having Br as compared to the chlorine containing derivative (68aa).

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PMC11342785

E, schematic depicting strategy for systematically varying the microtubule-interaction component (TPPP variant) of an inducible synMAP TPPP-IDR circuit.

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PMC11180402

The most common type of BC is non-muscle invasive bladder cancer (NMIBC), which accounts for 75% of newly diagnosed BC; MIBC accounts for 25% of all new diagnoses .

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PMC11633763

DUB has recently emerged as a possible target for numerous tumour therapies .

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PMC6684588

These findings indicate that endogenous follistatin exerts an important regulatory influence on Smad2/3 pathway signaling in adult muscle under both normal and pathologic conditions.

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PMC9027909

The study was approved by the ethics committee/institutional review board of the Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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PMC7642379

Results showed a significant consensus of down-regulation of genes involved in extracellular matrix organization, locomotion and cell adhesion in progeny cells compared to the parental HEK293 strain (Fig. 3a).

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PMC6835428

The diameter of lacuna aperture is 1.8–6 μm in most animal species, and 3.2–3.6 μm in humans.

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PMC11711663

RCVL1 and RCVL2, referred to as “re-substitution CVL”, establish an upper bound for the variation in the CVL value caused by random cross-validation.

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