PMCID string | Sentences string | ner list |
|---|---|---|
PMC11087301 | Despite being derived from the primary tumor tissue, CTCs depict molecular diversities including stemness and mesenchymal features, even two distinct CTC from an individual patient may reveal different molecular characteristics . | [
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PMC11596967 | At the end of the incubation period, colonies were fixed with 70% methanol and stained with 0.5% crystal violet. | [
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PMC11506670 | Band signals were visualized using an enhanced chemiluminescence substrate Luminata™ Classico Western HRP Substrate (Cat No. WBLUC0500; Merck Millipore, Burlington, MA, USA), and captured using the ChemiDoc Touch Imaging System (Bio-Rad Laboratories, Inc., Hercules, CA, USA). | [
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PMC9599726 | The expression of other genes related to ferroptosis was not altered (Figure 7A, upper panels). | [
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PMC11594074 | Three independent docking simulations were performed for each compound. | [
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PMC9429973 | Four patients (Patients 1, 3, 4, and 5) had adequate RIC melphalan exposure (AUC = 6.8-10.1 mg.h/L) following a 140 mg/m dose, maintaining a ratio of 72-97% at 6 months, which has remained stable. | [
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PMC9429973 | Three cell-dose levels were evaluated: DL1 (3x10/kg), DL2 (5x10/kg) and DL3 (10x10/kg) CAR30 T-cells. | [
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PMC9429973 | 10 selected physicians from Albanian Association of Hematology from 7 centers across the country fulfilled a questionnaire (survey) for each SCD patient, based on patient medical history (retrospective data) and interviewing the patient live (collecting primary data-EQ-5D instruments). | [
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PMC11438317 | The ABL Ab was from BD Pharmingen (Franklin Lakes, NJ). | [
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PMC11687663 | The discovered peaks are labelled as tentative due to the presence of natural products in isomeric forms, including isomerization of aglycones (e.g. flavones and isoflavones), or as isobaric compounds with the same molecular weight but distinct elemental composition . | [
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PMC11024707 | It is suggested that mi-RNA-23a has a potential modulatory function in CNS diseases In a study comparing mi-RNA-23a levels in lymphoblasts obtained from patients with autism and control subjects, it was shown that there was a higher level of expression in patients with ASD . | [
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PMC11673128 | Cells were finally stained with 7-AAD (Miltenyi Biotech) for viability for 5 min in the dark at room temperature. | [
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PMC11711345 | The performance of the in vitro assay was successful for all cell lines as seen by the cytotoxic responses to the positive control (p < 0.001, ANOVA followed by Dunnett´s test) (Figure 2). | [
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PMC8992508 | Therefore, new and innovative strategies, such as the fallback to natural products and the discover of dual activity ligands emerged as new perspectives. | [
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PMC11499955 | Fluorescence imaging after addition of DBCO-TAMRA confirmed efficient and selective click-and-release reaction on tissue sections (Fig. 5B). | [
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PMC9429973 | Disease control rate defined as SD and above was 70%. | [
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PMC9429973 | However, at relapse, OS is approximately 40-50%. | [
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PMC8711270 | The COVID-19 pandemic drove the rapid development of adenoviral vectored vaccines and their eventual emergency use (Mendonça et al., 2021). | [
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PMC10565698 | CircRNAs are a class of ncRNAs, most of which are closed-loop structures formed by exons . | [
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PMC11397654 | Comparing the cytotoxicity of the L-proline-substituted calixarenes with their unsubstituted counterparts might also allow for assessing the importance of L-proline in the antitumour activity of the calixarene derivatives. | [
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PMC11683240 | First, the inhibiting effect of α1AT on the intoxication of CHO-K1 cells and lung adenoma A549 cells was confirmed by analyzing the ADP-ribosylation status of Gαi (Fig. 2). | [
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PMC11473750 | Thus, RNF121 represents an attractive therapeutic vulnerability in neuroblastoma, particularly as mice hemizygous for a hypo-functioning RNF121 allele appeared healthy. | [
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PMC11743975 | Niclosamide was purchased from Sigma Aldrich (St. Louis, MO, United States, No. N3510). | [
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PMC10957991 | Permeabilization and simultaneous blocking of non-specific binding was performed with 0.1% Triton X-100 in Dulbecco-BSA for 5 min. | [
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PMC9429973 | Serum inflammatory markers (CRP, interleukin-6, procalcitonin) were recorded daily, and the baseline CAR-HEMATOTOX score (Rejeski et al Blood 2021) was assessed for each patient. | [
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PMC6889484 | One copy of the overlapping ∼900-bp direct repeat is efficiently deleted during reverse transcription by HIV-1 reverse transcriptase switching templates in the homologous repeats, resulting in the functional reconstitution of A3G-D128K (Figure S1; reviewed by Delviks-Frankenberry et al.). | [
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PMC11552389 | Consistent with in vitro results, our data show that over-expression of FOXN3 inhibits melanoma cell proliferation in vivo. | [
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PMC10831439 | Despite being rare in peripheral blood, iNKT cells can be easily expanded ex vivo to achieve cell numbers, which are necessary for clinical applications. | [
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PMC10571053 | Additionally, we found that the FINs ML-162, GPX inhibitor 26a, and PACMA31 act as inhibitors of P-gp. | [
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PMC11640476 | B1/S1: days 1, 4, 7, and 11 (4 times); B2/S2: days 4, 7, and 11 (3 times); B3/S3: days 7 and 11 (2 times); B4/S4: day 11 (1 time). | [
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PMC11471176 | After careful mixing, the cells are cultured at 37 °C in a carbon dioxide incubator for specified durations. | [
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PMC11767582 | The plate was incubated for a further 3 h (37 °C). | [
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PMC10788478 | The number of input reads was more than 33.3 million. | [
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PMC11055510 | SKOV3 cells are a commonly used human ovarian cancer cell line that is often used as a model for in vitro studies. | [
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PMC11790971 | In addition to the monoclonal wells, which contained cells from one of the four cell lines, artificial pools were created by deliberately mixing cells from different cell lines to simulate the cell line selection process. | [
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PMC9429973 | When we infected Pax5 and WT mice with LCMV-Docile, we found that innate (early interferon production) and adaptive immune responses (tetramer positive CD8 T cells and early viral titers) were not intrinsically impaired in Pax5 mice. | [
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PMC11765879 | Ghaffari et al. reported that ZSC leaf extract induces apoptosis in the MCF-7 cell line by activating the pro-apoptotic marker Bax . | [
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PMC10631132 | Image quantitation confirmed the significant differences between both protocols (Fig. 5I) while demonstrating no significant differences in osteoclasts differentiated according to the EB protocol (Fig. 5J and K) using either the PBMC or fibroblast-derived cell line. | [
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PMC11803918 | When CCR5 or PD-1 was blocked by neutralizing αCCR5 or αPD-1 monoclonal antibody (mAb), the uptake level of hybrid exosomes in A375 cells was significantly decreased compared with that of the isotype IgG control (Figure 3C). | [
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PMC9429973 | In zanubrutinib patients, the dose of 160 mg BID was more commonly administered (64%) than 320 mg QD (31%). | [
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PMC11775197 | Then, it regulates the cell cycle, promoting apoptosis and inhibiting cell proliferation via the RB/E2F pathway. | [
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PMC11718109 | Strikingly, when VMAT2-GFP, synaptophysin and mCherry-synapsin were co-expressed together, VMAT2 vesicles and synaptophysin vesicles segregated from each other and assembled into distinct phases within the mCherry-synapsin phase, with synapsin being more concentrated (based on a higher fluorescence intensity) in the sy... | [
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PMC7723249 | Most interestingly, supernatant from CCHFV-infected moDCs increased the level of basolateral infection over one log compared to control, while no effect was observed on apical infection (Fig 3C). | [
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PMC11529598 | Quantitative real-time polymerase chain reaction (qRT-PCR) was carried out using TaqMan MicroRNA assay kits (Applied Biosystems). | [
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PMC10818573 | Multiple reports in the literature have described the detection of EBV infection in various cell types maintained in cell culture banks ; these infections can be attributed to the presence of an existing EBV infection during the initial process of cell line establishment, EBV contamination of culturing materials, or im... | [
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PMC11747949 | In tumor stroma analysis we noted an increase in CD11bCD86 cells after CCR2 inhibition. | [
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PMC11317131 | Similar to others, we observed lower PE efficiencies using a single pegRNA (22,60), with PASTE PE and integration into the ROSA26 locus reaching 11.2% and 2.4%, respectively. | [
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PMC11767725 | IGF-1 activates the phosphoinositide 3-kinase (PI3K)/Akt and mammalian target of rapamycin complex 1 (mTORC1) pathways, driving sebocyte proliferation and increasing sebum lipid synthesis. | [
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PMC6889484 | To circumvent APOBEC3 expression in virus-producing cells, which diminishes virus infectivity, a vector containing two overlapping fragments of A3G-D128K was designed that maintained the gene in an inactive form in the virus-producer cells. | [
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PMC6835428 | This was the case in the work presented by Mendes et al. (Table 7). | [
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PMC10671321 | A proline-rich domain (PRAD) at the N-terminus of ColQ allows its association with acetylcholinesterase (AChE), an enzyme that hydrolyzes acetylcholine and thus controls the duration of the synaptic transmission. | [
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PMC5925824 | Tables list the Log2 fold-change of LY3300054 vs control group for genes with fold-change > 1.5, p value < 0.05. | [
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PMC11078693 | We immunostained the RPMI 8226 cells with TUBB4A antibodies at a final concentration of 10 μg /mL from 1:30 dilution of a 300 μg /mL stock concentration obtained following the probe conjugation with Biotium CF568 Mix-n-Stain kit according to the manufacturer’s instructions: https://biotium.com/wp-content/uploads/2017/1... | [
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PMC11767817 | Potential molecular targets were also analyzed. | [
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PMC9964654 | The Au uptake in A2780 cells, determined by PIXE, was ca. | [
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PMC11701801 | These results indicate that inhibiting CBP/p300 in SMARCA4/SMARCA2-deficient cells and SS18–SSX fusion cells induces apoptosis by downregulating KREMEN2. | [
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PMC8735881 | Given the disappointed results of allogeneic transplantation of CCR5 gene-edited HSCs in patients and concerns over the deleterious effects of the CCR5Δ32 mutation, we generally consider that knocking in antiviral genes is a safer and more efficient way than the deletion or disruption of host cell genes to modify cells... | [
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PMC11698348 | Approximately, two-thousand HF bulge SCs or ten thousand epidermal SCs were seeded per 24-well plate and incubated for 48 hours with DMEM/F-12 media (3:1) supplemented with 10% chelated fetal bovine serum, 10ng/ml epidermal growth factor, 0.5μg/ml hydrocortisone, 10M cholera toxin, 5μg/ml insulin, 1.8M Adenine (Merck, ... | [
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PMC11767817 | Thus, compound 2a increased the level of p-Akt two-fold compared to the control cells, while the effects of curcumin and compound 2a-B were comparable. | [
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PMC11519567 | Data are mean±s.d., | [
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PMC11092418 | However, the same combination was found to be antagonistic in LN-18 and A172 cells, which were cultured in the medium containing 2% and 10% serum, respectively, highlighting the complex and heterogeneous nature of brain cancer (Table 4). | [
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PMC11001582 | This analysis revealed that ECM-associated proteins were not altered in lumbar spinal cord of 12-month-old eGFP knock-in mice (Extended Data Fig. 8d). | [
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PMC11779993 | The HPLC was performed using the Shim-pack GISS C18 column at 4.6 × 150 mm and 5 μm of particle size. | [
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PMC11502327 | The parental cell characteristics of EXO are reflected in surface markers, contents and cell activation pathways. | [
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PMC10577955 | Finally by targeting the Let-7 miRNA/Cyclin D1/VEGF cascade, acetoxy-lup-5(6), 20(29)-diene could be a potential therapeutic agent for lung cancer. | [
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PMC8922418 | PE is more suitable for active windows with multiple cytosine/adenines or unacceptable bystander edits. | [
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PMC10729469 | To overcome this limitation, we generated TCRAβ-Tregs that transiently express an Aβ-specific TCR by electroporation of a plasmid encoding the TCRAβ. | [
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PMC10174970 | The accuracy of such studies is highly dependent on the phenotypic and genetic similarity of cell lines to patient tumors, but this is not always the case, particularly for pancreatic cancer. | [
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PMC7452526 | The colloidal sample was prepared by adding a small amount of distilled water to the washed silver nanoparticles and dissolve it using the ultrasonic bath for 15 min The preliminary characterization of AgNPs was carried out using UV-visible spectrophotometer (Cary 5000) and a cell with 1cm path length. | [
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PMC11615828 | Although clustering and immobilization of synaptic vesicles can be triggered under comparable kinetics (Figures 5 and 6a; Table S1 and Videos S4, S25–S27, Supporting Information), , RIVET‐mediated synaptic vesicle trapping on MTs takes significantly longer time (≈5 min) to attenuate animal locomotion compared to synapt... | [
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PMC11537649 | I and J) Cell apoptosis was evaluated by flow cytometry. * | [
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PMC11806106 | DAMGO and fentanyl displayed a slightly slower affinity for receptor activation and induced a slightly slower activation as well. | [
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PMC9429973 | This was in the same range as EC50s of daratumumab and the HexaBody-CD38 parental antibody without E430G mutation, suggesting that the hexamerization mutation has limited impact on trogocytosis induction. | [
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PMC11461025 | Cells were treated in triplicate. | [
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PMC11796104 | GO analysis indicated several significantly enriched terms, such as, protein transport (p = 1.11E-11), chromatin organization (p = 2.68E-10), cytosol (p = 2.97E-44) and protein binding (p = 5.09E-72) (Figure S1A-C). | [
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PMC11271278 | Previous studies have identified various potential enhancers within regions of this translocation, but a consensus regarding which one regulates ETV1 has not yet been reached. | [
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PMC9688728 | Here, we report only the difference in pathways rating but would like to emphasize the importance of comparing the results of pathway analysis against different databases when the researcher is faced with a specific task, for example, exploring the metabolomic profile of a biological object exposed to a particular drug... | [
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PMC11700523 | The 5/6 Nx group showed significantly high levels of serum creatinine, IS, and urinary proteins compared with the sham group but decreased plasma aldosterone levels (Figure 1A-1D). | [
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PMC11721277 | To evaluate the lipophilicity of [Tc]Tc-HYNIC-Chl, the water–n-octanol distribution coefficient was determined. | [
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PMC5417661 | First, the compound passed the Lucifer yellow monolayer integrity test criteria (<0.8×10 cm/s). | [
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PMC10976516 | Therefore, if OV-loaded carrier cells have a tropism toward a specific organ (for example, the lung or the liver) it may be necessary to modify the virus to make the normal cells from that organ specifically resistant to infection. | [
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PMC8662250 | The identification of immunomodulatory and anti‐inflammatory compounds able to reduce NLRP3 activation triggered by SARS‐CoV‐2 SP can be regarded with particular interest especially at intestinal epithelium level. | [
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PMC7868205 | The metal ions interact with the phytochemicals of the plant which eventually reduce the metal ions. | [
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PMC11585565 | Fig. 2b, Supplementary Table S3). | [
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PMC6600253 | Chemotherapeutic drugs can also trigger cellular senescence by permanent cell cycle arrest. | [
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PMC11799978 | Protein lysates were mixed with 1× sodium dodecyl sulfate–polyacrylamide gel electrophoresis protein loading buffer (20315ES05, Yeasen) and boiled at 100 °C for 10 min before being subjected to electrophoresis using a FuturePAGE 4–20% gradient gel (ACE) at a voltage of 90 V for 40 min and then at a voltage of 120 V for... | [
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PMC10965680 | It is generally accepted that the greater the genetic diversity of a species is, the more adaptable its offspring will be (therefore, expansion is more likely to occur). | [
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11727907 | The cells were grown to confluence, removed with trypsin-EDTA (Euroclone, Milan, Italy), and then seeded in multiwell plates for all experiments. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11742431 | Cell lines not treated with KVN or K14N proteins were controls. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Cell",
"lines",
"not",
"treated",
"with",
"KVN",
"or",
"K14N",
"proteins",
"were",
... |
PMC9429973 | The new method appears more amenable to digital scanning and analysis. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"new",
"method",
"appears",
"more",
"amenable",
"to",
"digital",
"scanning",
"a... |
PMC11472569 | As a crucial regulator of ABCG2 localization, suppression of the PI3K-Akt signaling pathway decreases the sorting of ABCG2 to EVs, eventually reducing EV production and reversing MDR. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11585587 | Venn diagram of potential targets of RA anti-MM; (B) PPI network of 58 Intersection targets. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Venn",
"diagram",
"of",
"potential",
"... |
PMC11750165 | The Y2H screening was performed as described manufacturer (Clonetech, Terra Bella, CA, USA). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"Y2H",
"screening",
"was",
"perf... |
PMC10674574 | It is common laboratory practice to replace the growth medium every other day. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"It",
"is",
"common",
"laboratory",
"practice",
"to",
"replace",
"the",
... |
PMC10547921 | In addition, using DNA-damaging agents as payloads can target tumor-specific/associated surface receptors at relatively low levels of expression. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"In",
"addition",
",",
"using",
... |
PMC7570809 | A total of 20,000 events per sample were collected. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"A",
"total",
"of",
"20,000",
"events",
"per",
"sample",
"were",
"collected",
"."
]
}
] |
PMC11629461 | UVA irradiation and SALPC photodynamic action triggered calcium oscillations in DUOX2‐CHO‐K1 cells. ( | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-CellLine",
"O",
"O",
"O"
],
"tokens": [
"UVA",
"irradiation",
"and",
"SALPC",
"photodynamic",
"action",
"triggere... |
PMC11052306 | For the weak complexes, the coordination sphere of copper was completed with oxygen atoms from the solvent. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"For",
"the",
"weak",
"complexes",
",",... |
PMC10154881 | A similar phenomenon was observed in our rMV‐SLAMblind cancer therapy. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"A",
"similar",
"phenomenon",
"was",
"observed",
"in",
"our",
"rMV‐SLAMblind",
"cancer",
"therapy... |
PMC11575040 | G, H After transfection with miR-1270 mimics for 48 h, the expression levels of LINC00094 and miR-1270 were detected by real-time PCR. * | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tok... |
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