OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC8414691	Finally, and most importantly, a direct role of SRCAP in cytokinesis is supported by results indicating that it interacts with cytokinesis regulators in co-IP assays of chromatin-free protein extracts from telophase-synchronized HeLa cells (Fig. 6), with the midbody recruitment of the same regulators depending on SRCAP...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5574817	Lane 1:1 kb DNA ladder; Lane 2: NotI restricted plasmid sample where 6 kb refers to the fragment of plasmid and 4 kb band refers to the hERG cDNA insert.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087055	The acquisition time was every 3 min using Nikon Elements Advance Research software V4.00.07.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "acquisition", "time", "was", "every", "3", "min", "using"...
PMC11434983	Each experimental point was repeated in tetraplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "experimental", "point", "was", "repeated", "in", "tetraplicate", "." ] } ]
PMC11607638	Minimum essential medium (MEM) amino acids mixture (50×, #11130‐051) and 0.25% Trypsin–EDTA (#52500056) were from Gibco™ (Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10933092	LncRNAs characteristically fulfill regulatory or structural roles in different biological and pathological activities and are distinct from protein-coding genes (Quinn and Chang, 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	The majority of patients were male (65%) and age > 60 years (77%), with most being aged 70-79 years (33% of total).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	Here, we propose a model of how ACKR3 controls the migration of the diffused large B-cell lymphoma VAL cells in vitro and in vivo in response to CXCL12.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055443	The relative gene expression of IL-8, IL-1β, and TNF-α inflammatory cytokines was increased by 2.27 ± 0.31, 4.76 ± 1.52, and 139.6 ± 5.47 fold respectively in Caco-2 cells treated with V. cholerae.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4355729	Overall, PIK3R1 down-regulation in RCC promotes propagation, migration, EMT and stem-like phenotype in renal cancer cells through the AKT/GSK3β/CTNNB1 pathway, and may contribute to progression and metastasis of RCC.Renal cell carcinoma (RCC) is one of the most lethal types of urological cancer1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11271278	B RT-qPCR measuring expression changes of ETV1 and FOXA1 after CRISPRi of each enhancer e1–e4 or the promoter of ETV1 in LNCaP cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ ...
PMC10452486	New reports are emerging on the functional diversity of the dimers in association with other cell surface receptors such as KIR and the leukocyte Ig-like family of receptors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	Data are shown as mean ± s.d. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", "mean", "±", "s.d", ".", "(" ] } ]
PMC9429973	Summary/Conclusion: Our study showed that WGOM detects SVs as translocations and aneuploidies in BCP-ALL as good as conventional methods with a 95% concordance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11295144	The animal study was approved by Ethics Committee University College London.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "animal", "study", "was", "approved", "by", "Ethics", "Committee", "University", ...
PMC11026382	f Correlation between experimentally measured and predicted growth rates for five DHFR point mutations in two TYMS backgrounds (same mutants as d, e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	B. Moses, J. LaMora, R. Nathan, F. Fisher, C. Tseng, J. Seehra, J. Lachey Keros Therapeutics, Lexington, United States of America Background: Transforming growth factor-beta (TGF-β) superfamily signaling is vital in regulating hematopoiesis, including normal platelet (PLT) production.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	CAR-T therapy was associated with statistically significant improved ORR and CR rates and longer EFS and PFS, translating into improved OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CAR-T", "the...
PMC11347429	After assigning ethnicity to every participant, we analyzed gene expression signals with respect to ethnicity (using Data file 20 and sample descriptions from Data file 1 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591052	It appears that 20E’s anabolic properties extend beyond muscle tissue and could potentially aid in the treatment of various pathologies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "appears", "...
PMC11049294	According to our results, the balance of fluorescent substrate accumulation and enzymatic degradation shifted in the direction of substrate uptake in the first 5 h. After 6 h of incubation, substrate reduction dominates as a result of enzymatic degradation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	For patients with advanced MDS, as defined by an excess of blasts, therapeutic options include hypomethylating agents and allogeneic stem cell transplantation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10545062	The bilateral common femoral arteries and left femoral vein were surgically exposed for arterial sheath and venous dual lumen hemorrhage and resuscitation catheter placement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11627060	The MTT assay was employed to assess the anti-carcinogenic effect by treating A549 cell lines with TQ-BSA NPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MTT", "assay", "was", ...
PMC11711871	G Determination of plasma concentrations of the glucocorticoids corticosterone, 11-dehydrocorticosterone and the corticosterone/11-dehydrocorticosterone ratio and H the mineralocorticoid aldosterone and its precursor 11-deoxycorticosterone in the morning (7–8 am) and afternoon (6–7 pm) of GR and GR. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700247	AH1 tetramer staining in the various treatment groups revealed a notable increase in AH1-specific T-cell infiltration in RT-treated tumors, as well as in nonirradiated tumors (Figure 3B-C).Figure 3.RT/CART-19 combination treatment enhances crosspresentation of TAAs and T-cell responses to TAAs. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10522430	All data were presented as mean ± SD and subsequently subjected to analysis using GraphPad Prism software version 8 (San Diego, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7759933	The ALB expression gradually increased and reached the maximal level at day 10 (9.56-fold) with a slightly decrease after 12 and 17 days (7.67-fold and 8.03-fold, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In addition, increased expression of PFRs is associated with bleeding history and sustained CT time at FIBTEM under ASA prophylaxis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ...
PMC11411131	Theoretically, full-length Krab-Sec could inhibit luciferase expression but not when exposed to MeHg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Theoretically", ",", "full-length", "Krab-Sec", "could", "inhibit", "l...
PMC11271278	We then prioritized HAPI genes that have a substantial amount of enhancer activity originating from other chromosomes or abnormally distant intra-chromosomal regions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then",...
PMC9429973	Despite the clinical significance of PROMs, patients are rarely involved in their development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "the", "clinical", "significance", "of", "PROMs", ",", ...
PMC10747139	complexes, namely RM175, RAED-C, and RAPTA-C, are 18-electron Ru–arene “piano-stool” complexes, in which an η-arene ring stabilizes the 2 oxidation state of the Ru metal center .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7553912	Protein expression of OSM and OSMRβ in the kidney on days 0, 3, 6, or 9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "expression", "of", "OS...
PMC10213179	The latter studies used an unbiased cell-based SELEX process that required identification of the target protein after the aptamer selection using biochemical methods (e.g., protein pull-down followed by mass spectrometry).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585254	Here, we set out to identify the receptor determinants responsible for β-arrestin-mediated regulation of the chemokine receptor C-X-C motif chemokine receptor 5 (CXCR5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11612508	The Scherrer equation, expressed as Dp = 0.9λ / (β cos θ), was employed to determine the crystallite size of the nanocrystalline samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11320084	Clinically, most patients with lung cancer (LC) die from tumor spread and metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinically", ",", "most", "patients", "with", "lung", ...
PMC11409031	Previous research has shown that CD4 T cells can either directly kill tumor cells via cell lysis or modulate the TME indirectly to target cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	The possible mechanisms include decreased platelet production, increased platelet destruction, and consumption.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "possible", "mechanisms", "include", "decreased", "platelet", "p...
PMC9429973	A patient was defined as relapsed/refractory (R/R) if they had commenced a drug which was in a different therapeutic category, or if they re-started the same regimen after a gap of more than 180 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The CR rate at Day 100 was 55% (95% CI: 32%, 76%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CR", "rate", "a...
PMC11185260	In some experiments, 24h after the initial injection of scL-SMARCB1, the animals were secured in a lead restraint that permitted only the tumor area to be exposed to γ-irradiation, and the first fractionated dose of 5 Gy of ionizing radiation was administered.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747139	Moreover, the relative neuraminidase activity of the H1N1+60 group was 66.3%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "relative", "neuraminidase", "activity", ...
PMC9325715	The redshifts were observed for the corresponding bands after Fe binding, indicating the weakening of the C-H bond.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "redshifts", "were", "obser...
PMC9429973	Summary/Conclusion: In patients with advanced MF, bomedemstat alone had an acceptable tolerability profile, relieved symptoms, reduced spleen volume and mutation burden while improving fibrosis and anemia without safety signals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median follow up time was 40.7 and 35.3 months, in the Len-only and Len-combo groups, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "follow", "up", "time", "was"...
PMC11419566	There are 4 phases in the cell cycle: G1, S, G2, and M. Cells in the G0 phase are also known as dormant cells, which are temporarily unable to proliferate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10809689	Therefore, we may probably conclude that although a large amount of glutamate was produced by GLS, GDH also consumed it, or even Glu may have been regenerated from other metabolic pathways such as transaminase activity with compensatory mechanisms .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	CPX-351, a dual-drug liposomal encapsulation of cytarabine and daunorubicin, improved significantly rates of remission and overall survival (Lancet JE et al, JCO 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9848491	In the internal validation cohort, the prognosis of the high-risk group was lower than that of the low-risk group ( Figure 5D , p=3.76e-03).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8409415	Cluster of differentiation 70 is a member of the tumor necrosis factor superfamily and the ligand for CD27.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cluster", "of", "differentiation", ...
PMC10604092	Anorexia in cancer is common in the advanced stages of several cancers and is often exacerbated by treatment-induced adverse effects (e.g., nausea, vomiting, and oral mucosal ulcers), decreased motor activity, tumor-related gastrointestinal obstruction, and psychological factors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	Per sample, a network of inferred kinase–substrate relations annotated with INKA scores is visualized using the R package “network” (Butts, 2008).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8345486	Cell lysates for protein content analysis were obtained from the same probe by repeatedly freezing and thawing the samples and by sonication for 1 min (Sonorex Digitec DT 31H, Bandelin electronic GmbH & Co. KG, Berlin, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	TEAEs reported in this study are consistent with the known safety profile of GO, and the presence of ADAs does not appear to be associated with any potential safety concerns.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11348300	Omitting fitting areas of stable oxygen (due to tissue not being palpated) is necessary to avoid introducing discrepancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Omitting", "fitting", "areas...
PMC10955424	Malignant ascites serves as a reservoir for a diverse mixture of soluble factors, metabolites, and cellular components.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Malignant", "ascites", "serves", ...
PMC11499381	For mVenus analysis, we explored whether the mVenus fluorescence arising from the interaction between V1–154 and V155–238 was above background levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "mVenu...
PMC7759933	These results show a steady growth of spheroids during the time of culture, which is in line with other studies on HepG2 spheroids .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "token...
PMC11607321	Dot size represents the number of cell lines that have the gene as essential (scaled log2 fold-change < −0.5) in the original dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC4816271	Over the duration of this culture period we noted differential decrease in levels of expression between the 3 groups: the unmodified (no SAR/CHS) and CHS receptors showed a substantial decrease in MFI up ranging from 22.4–49.5% compared with the day 3 MFI (Fig 4D compared with Fig 4C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7762347	Similarly, it has been reported for micronuclei formation where CYN induced genomic instability in HepG2 cells to a similar extent as the combination with MCLR .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9219615	Fgr and Hck are blood cell-specific Src kinases that were hyperphosphorylated in cells exposed to Tpz-1 (Figure 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fgr", "and", "Hck", "a...
PMC11344246	Briefly, we took gene expression data from a previous study of both MOC and benign mucinous ovarian tumours and created an edge-weighted network of MOC enriched gene co-expression by performing differential network analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A total of 18 follow-up samples were analyzed with a threshold for EMR positivity set at 1x10^ (-4) as we previously described (Onecha E et al. Haematologica 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8839885	Platinum (Pt)-based chemotherapy is the standard of care for OC, but toxicity and acquired chemoresistance has proven challenging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Platinum", "(Pt)-based", "chemotherapy"...
PMC11307990	786-0 cells (0.6 × 10 in 200 μL of medium) were seeded in 35 mm confocal dishes and cultured overnight.	[ { "tags": [ "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11095939	Using genetic mouse models, cellular models, and genome-wide approaches, we uncovered a regulatory capacity of Mecp2 in quiescence exit (Figure 7I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10748106	Some iridoid glycosides do not inherently possess antiproliferative activity; instead, they exhibit effects on human cancer cells once they undergo hydrolysis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", ...
PMC7553912	d,e) Quantitative analysis of the protein expressions of OSM and OSMRβ.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", ",", "e", ")", "Quantitative", "analysis", "of", "the", ...
PMC11806613	MDA-MB-231 cells were treated with 1 µL/mL of ethanol control or OST-01 (1 µL of OST-01 extract contains 250 µg of dry plant extract) for 24 h. A Left, mRNA levels were measured by qPCR.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792888	Next, we decided to corroborate the relationship between cell cycle arrest and apoptotic cell death after scorpion venom treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "dec...
PMC11640555	A lower concentration of CX-4945 (5 μM) did not reduce its expression (Figure 2A, densitometric analysis Figure 2(A1)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8996378	The ATPase activity of ABCB1 is one of the most attractive targets for the design of inhibitors (Mollazadeh et al., 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10587429	An inherent limitation of the current model is that patient derived xenograft tumors cannot be directly transplanted orthotopically due to the limited space in the site of administration (tibia).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10919056	Clinical nomogram. (	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Clinical", "nomogram", ".", "(" ] } ]
PMC11507371	To verify this in the context of the utilised cell lines and plasma setup of this study, the cell viability was assessed after exposure to plasma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11047729	Tocotrienol and ferulic acid work synergistically and greatly decrease hTERT expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tocotrienol", "and", "ferulic", "acid", "work", "synergistically", "and", "greatly", "decre...
PMC10606998	As a comparison of Figure 3a,b indicates, according to the Resazurin assay results, the radiosensitization effect is more pronounced in the Gl-Tr culture, suggesting a specificity of cell lines to the action of gamma irradiation in the presence of SPIONs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6034753	GST-Apoptin was used against MSB-1 lysate and (B) GST-Meq (1–170) against induced U2OS-Apoptin lysate.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "GST-Apoptin", "was", "used", ...
PMC11758416	The authors declare no competing interests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "authors", "declare", "no", "competing", "interests", "." ] } ]
PMC10877303	Fig. 7e indicates that most residues had RMSF values lower than 2.5 Å, with minor fluctuations, signifying the stability of the complexes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11763764	Therefore, we propose to further explore the potential of FGFR4 inhibitors in targeting recurrent ovarian cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "propose", "to", "fu...
PMC9532503	The association (ka), dissociation (kd) constants, and binding affinity (KD) data were analyzed using Biacore T200 evaluation software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11224020	We conclude that upregulation of both cell motility and CCR7 expression in DCs confined at a height of 3 µm relies on the activity of the cPLA2 enzyme.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615101	Both cell lines (RAFLS and SW982) were cultured in 96-well culture plates and treated with different doses of TNF-α (1, 5, 10, 20, and 40ng/ml)/α-Taxilin (0, 6.25, 12.5, 25, 50, and 100ng/ml).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11721587	Previous studies showed that forced dimerization of Fu through a coiled-coil (CC) domain from GCN4 (CC-Fu) is sufficient to induce its kinase activation (26, 28).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11119602	Although the association of TG2 with membrane structures is not completely understood, several studies have advanced the idea that TG2 can interact with specific membrane-associated proteins during autophagy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	For eligible patients, standard treatment includes intensive chemotherapy during induction, followed by consolidative chemotherapy or stem cell transplantation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "eligible", "patients"...
PMC9429973	Our data highlight the significant morbidity and mortality burden incurred by patients with MPN-SVT, including a substantially lower rate of re-canalisation compared to a recent meta-analysis of all patients with SVT and high rates of thrombosis recurrence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11127909	Hence, there is an urgent need to comprehend the mechanism underlying drug resistance in OS and to seek novel strategies for effective treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11244823	Cellular extract expressing gD1(402)-nLuc-V5-H6X and media supernatant of cells expressing gD1(83)-nLuc-V5-H6X were migrated in duplicated in SDS-polyacrylamide gels (SDS-PAGE) as described previously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10158546	Specifically, through repeated measurements of amyloid seeding activity in 6-week time course experiments, we failed to observe replication of MM1 and VV2 type sCJD, or RML and 263K rodent adapted scrapie.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	Cells were expanded and Dox response (GFP-expression as surrogate marker) re-validated after thawing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "expanded", "and", "Dox", "response", "(", ...
PMC11515150	With regard to survival and proliferation in vivo, engineered anti-CD19 CAR-NK cells with IL-15 and inducible caspase-9 had successfully entered phase II clinical trial (NCT03056339) and the overall response rate (ORR) was up to 73% (8/11) without obvious toxic effects .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11650848	Functional consequences of altered methylation were examined in cultured cells with mutations or by inhibition of the main DNA methyltransferases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Functional", "consequences", ...
PMC10747160	More concerningly, the most recent Omicron strains display numerous mutations in their spike protein sequences, which have allowed them to establish breakthrough infections in patients who have received multiple booster doses of COVID-19 vaccines .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10588957	The effect of DATS on the cell viability of HepG2. ( *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "DATS", "on", "the", "cell", "viability", "of", ...
PMC2777936	This may be caused by a difference in the stability or effectiveness of the individual siRNA species or possibly a difference in the rate at which they silence their gene targets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8414691

Finally, and most importantly, a direct role of SRCAP in cytokinesis is supported by results indicating that it interacts with cytokinesis regulators in co-IP assays of chromatin-free protein extracts from telophase-synchronized HeLa cells (Fig. 6), with the midbody recruitment of the same regulators depending on SRCAP...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5574817

Lane 1:1 kb DNA ladder; Lane 2: NotI restricted plasmid sample where 6 kb refers to the fragment of plasmid and 4 kb band refers to the hERG cDNA insert.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11087055

The acquisition time was every 3 min using Nikon Elements Advance Research software V4.00.07.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "acquisition", "time", "was", "every", "3", "min", "using"...

PMC11434983

Each experimental point was repeated in tetraplicate.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "experimental", "point", "was", "repeated", "in", "tetraplicate", "." ] } ]

PMC11607638

Minimum essential medium (MEM) amino acids mixture (50×, #11130‐051) and 0.25% Trypsin–EDTA (#52500056) were from Gibco™ (Shanghai, China).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10933092

LncRNAs characteristically fulfill regulatory or structural roles in different biological and pathological activities and are distinct from protein-coding genes (Quinn and Chang, 2016).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

The majority of patients were male (65%) and age > 60 years (77%), with most being aged 70-79 years (33% of total).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9878562

Here, we propose a model of how ACKR3 controls the migration of the diffused large B-cell lymphoma VAL cells in vitro and in vivo in response to CXCL12.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11055443

The relative gene expression of IL-8, IL-1β, and TNF-α inflammatory cytokines was increased by 2.27 ± 0.31, 4.76 ± 1.52, and 139.6 ± 5.47 fold respectively in Caco-2 cells treated with V. cholerae.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4355729

Overall, PIK3R1 down-regulation in RCC promotes propagation, migration, EMT and stem-like phenotype in renal cancer cells through the AKT/GSK3β/CTNNB1 pathway, and may contribute to progression and metastasis of RCC.Renal cell carcinoma (RCC) is one of the most lethal types of urological cancer1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11271278

B RT-qPCR measuring expression changes of ETV1 and FOXA1 after CRISPRi of each enhancer e1–e4 or the promoter of ETV1 in LNCaP cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ ...

PMC10452486

New reports are emerging on the functional diversity of the dimers in association with other cell surface receptors such as KIR and the leukocyte Ig-like family of receptors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11224020

Data are shown as mean ± s.d. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", "mean", "±", "s.d", ".", "(" ] } ]

PMC9429973

Summary/Conclusion: Our study showed that WGOM detects SVs as translocations and aneuploidies in BCP-ALL as good as conventional methods with a 95% concordance.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11295144

The animal study was approved by Ethics Committee University College London.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "animal", "study", "was", "approved", "by", "Ethics", "Committee", "University", ...

PMC11026382

f Correlation between experimentally measured and predicted growth rates for five DHFR point mutations in two TYMS backgrounds (same mutants as d, e).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

B. Moses, J. LaMora, R. Nathan, F. Fisher, C. Tseng, J. Seehra, J. Lachey Keros Therapeutics, Lexington, United States of America Background: Transforming growth factor-beta (TGF-β) superfamily signaling is vital in regulating hematopoiesis, including normal platelet (PLT) production.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

CAR-T therapy was associated with statistically significant improved ORR and CR rates and longer EFS and PFS, translating into improved OS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CAR-T", "the...

PMC11347429

After assigning ethnicity to every participant, we analyzed gene expression signals with respect to ethnicity (using Data file 20 and sample descriptions from Data file 1 ).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11591052

It appears that 20E’s anabolic properties extend beyond muscle tissue and could potentially aid in the treatment of various pathologies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "appears", "...

PMC11049294

According to our results, the balance of fluorescent substrate accumulation and enzymatic degradation shifted in the direction of substrate uptake in the first 5 h. After 6 h of incubation, substrate reduction dominates as a result of enzymatic degradation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

For patients with advanced MDS, as defined by an excess of blasts, therapeutic options include hypomethylating agents and allogeneic stem cell transplantation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10545062

The bilateral common femoral arteries and left femoral vein were surgically exposed for arterial sheath and venous dual lumen hemorrhage and resuscitation catheter placement.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11627060

The MTT assay was employed to assess the anti-carcinogenic effect by treating A549 cell lines with TQ-BSA NPs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MTT", "assay", "was", ...

PMC11711871

G Determination of plasma concentrations of the glucocorticoids corticosterone, 11-dehydrocorticosterone and the corticosterone/11-dehydrocorticosterone ratio and H the mineralocorticoid aldosterone and its precursor 11-deoxycorticosterone in the morning (7–8 am) and afternoon (6–7 pm) of GR and GR. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11700247

AH1 tetramer staining in the various treatment groups revealed a notable increase in AH1-specific T-cell infiltration in RT-treated tumors, as well as in nonirradiated tumors (Figure 3B-C).Figure 3.RT/CART-19 combination treatment enhances crosspresentation of TAAs and T-cell responses to TAAs. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10522430

All data were presented as mean ± SD and subsequently subjected to analysis using GraphPad Prism software version 8 (San Diego, CA, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7759933

The ALB expression gradually increased and reached the maximal level at day 10 (9.56-fold) with a slightly decrease after 12 and 17 days (7.67-fold and 8.03-fold, respectively).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

In addition, increased expression of PFRs is associated with bleeding history and sustained CT time at FIBTEM under ASA prophylaxis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ...

PMC11411131

Theoretically, full-length Krab-Sec could inhibit luciferase expression but not when exposed to MeHg.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Theoretically", ",", "full-length", "Krab-Sec", "could", "inhibit", "l...

PMC11271278

We then prioritized HAPI genes that have a substantial amount of enhancer activity originating from other chromosomes or abnormally distant intra-chromosomal regions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then",...

PMC9429973

Despite the clinical significance of PROMs, patients are rarely involved in their development.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "the", "clinical", "significance", "of", "PROMs", ",", ...

PMC10747139

complexes, namely RM175, RAED-C, and RAPTA-C, are 18-electron Ru–arene “piano-stool” complexes, in which an η-arene ring stabilizes the 2 oxidation state of the Ru metal center .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7553912

Protein expression of OSM and OSMRβ in the kidney on days 0, 3, 6, or 9.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "expression", "of", "OS...

PMC10213179

The latter studies used an unbiased cell-based SELEX process that required identification of the target protein after the aptamer selection using biochemical methods (e.g., protein pull-down followed by mass spectrometry).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11585254

Here, we set out to identify the receptor determinants responsible for β-arrestin-mediated regulation of the chemokine receptor C-X-C motif chemokine receptor 5 (CXCR5).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11612508

The Scherrer equation, expressed as Dp = 0.9λ / (β cos θ), was employed to determine the crystallite size of the nanocrystalline samples.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11320084

Clinically, most patients with lung cancer (LC) die from tumor spread and metastasis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinically", ",", "most", "patients", "with", "lung", ...

PMC11409031

Previous research has shown that CD4 T cells can either directly kill tumor cells via cell lysis or modulate the TME indirectly to target cancer cells .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

The possible mechanisms include decreased platelet production, increased platelet destruction, and consumption.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "possible", "mechanisms", "include", "decreased", "platelet", "p...

PMC9429973

A patient was defined as relapsed/refractory (R/R) if they had commenced a drug which was in a different therapeutic category, or if they re-started the same regimen after a gap of more than 180 days.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The CR rate at Day 100 was 55% (95% CI: 32%, 76%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CR", "rate", "a...

PMC11185260

In some experiments, 24h after the initial injection of scL-SMARCB1, the animals were secured in a lead restraint that permitted only the tumor area to be exposed to γ-irradiation, and the first fractionated dose of 5 Gy of ionizing radiation was administered.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10747139

Moreover, the relative neuraminidase activity of the H1N1+60 group was 66.3%.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "relative", "neuraminidase", "activity", ...

PMC9325715

The redshifts were observed for the corresponding bands after Fe binding, indicating the weakening of the C-H bond.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "redshifts", "were", "obser...

PMC9429973

Summary/Conclusion: In patients with advanced MF, bomedemstat alone had an acceptable tolerability profile, relieved symptoms, reduced spleen volume and mutation burden while improving fibrosis and anemia without safety signals.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Median follow up time was 40.7 and 35.3 months, in the Len-only and Len-combo groups, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "follow", "up", "time", "was"...

PMC11419566

There are 4 phases in the cell cycle: G1, S, G2, and M. Cells in the G0 phase are also known as dormant cells, which are temporarily unable to proliferate.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10809689

Therefore, we may probably conclude that although a large amount of glutamate was produced by GLS, GDH also consumed it, or even Glu may have been regenerated from other metabolic pathways such as transaminase activity with compensatory mechanisms .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

CPX-351, a dual-drug liposomal encapsulation of cytarabine and daunorubicin, improved significantly rates of remission and overall survival (Lancet JE et al, JCO 2018).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9848491

In the internal validation cohort, the prognosis of the high-risk group was lower than that of the low-risk group ( Figure 5D , p=3.76e-03).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC8409415

Cluster of differentiation 70 is a member of the tumor necrosis factor superfamily and the ligand for CD27.,

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cluster", "of", "differentiation", ...

PMC10604092

Anorexia in cancer is common in the advanced stages of several cancers and is often exacerbated by treatment-induced adverse effects (e.g., nausea, vomiting, and oral mucosal ulcers), decreased motor activity, tumor-related gastrointestinal obstruction, and psychological factors .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6461034

Per sample, a network of inferred kinase–substrate relations annotated with INKA scores is visualized using the R package “network” (Butts, 2008).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8345486

Cell lysates for protein content analysis were obtained from the same probe by repeatedly freezing and thawing the samples and by sonication for 1 min (Sonorex Digitec DT 31H, Bandelin electronic GmbH & Co. KG, Berlin, Germany).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

TEAEs reported in this study are consistent with the known safety profile of GO, and the presence of ADAs does not appear to be associated with any potential safety concerns.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11348300

Omitting fitting areas of stable oxygen (due to tissue not being palpated) is necessary to avoid introducing discrepancies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Omitting", "fitting", "areas...

PMC10955424

Malignant ascites serves as a reservoir for a diverse mixture of soluble factors, metabolites, and cellular components.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Malignant", "ascites", "serves", ...

PMC11499381

For mVenus analysis, we explored whether the mVenus fluorescence arising from the interaction between V1–154 and V155–238 was above background levels.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "mVenu...

PMC7759933

These results show a steady growth of spheroids during the time of culture, which is in line with other studies on HepG2 spheroids .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "token...

PMC11607321

Dot size represents the number of cell lines that have the gene as essential (scaled log2 fold-change < −0.5) in the original dataset.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC4816271

Over the duration of this culture period we noted differential decrease in levels of expression between the 3 groups: the unmodified (no SAR/CHS) and CHS receptors showed a substantial decrease in MFI up ranging from 22.4–49.5% compared with the day 3 MFI (Fig 4D compared with Fig 4C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7762347

Similarly, it has been reported for micronuclei formation where CYN induced genomic instability in HepG2 cells to a similar extent as the combination with MCLR .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9219615

Fgr and Hck are blood cell-specific Src kinases that were hyperphosphorylated in cells exposed to Tpz-1 (Figure 5).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fgr", "and", "Hck", "a...

PMC11344246

Briefly, we took gene expression data from a previous study of both MOC and benign mucinous ovarian tumours and created an edge-weighted network of MOC enriched gene co-expression by performing differential network analysis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

A total of 18 follow-up samples were analyzed with a threshold for EMR positivity set at 1x10^ (-4) as we previously described (Onecha E et al. Haematologica 2019).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8839885

Platinum (Pt)-based chemotherapy is the standard of care for OC, but toxicity and acquired chemoresistance has proven challenging.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Platinum", "(Pt)-based", "chemotherapy"...

PMC11307990

786-0 cells (0.6 × 10 in 200 μL of medium) were seeded in 35 mm confocal dishes and cultured overnight.

[ { "tags": [ "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...

PMC11095939

Using genetic mouse models, cellular models, and genome-wide approaches, we uncovered a regulatory capacity of Mecp2 in quiescence exit (Figure 7I).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC10748106

Some iridoid glycosides do not inherently possess antiproliferative activity; instead, they exhibit effects on human cancer cells once they undergo hydrolysis .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", ...

PMC7553912

d,e) Quantitative analysis of the protein expressions of OSM and OSMRβ.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", ",", "e", ")", "Quantitative", "analysis", "of", "the", ...

PMC11806613

MDA-MB-231 cells were treated with 1 µL/mL of ethanol control or OST-01 (1 µL of OST-01 extract contains 250 µg of dry plant extract) for 24 h. A Left, mRNA levels were measured by qPCR.

[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11792888

Next, we decided to corroborate the relationship between cell cycle arrest and apoptotic cell death after scorpion venom treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "dec...

PMC11640555

A lower concentration of CX-4945 (5 μM) did not reduce its expression (Figure 2A, densitometric analysis Figure 2(A1)).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC8996378

The ATPase activity of ABCB1 is one of the most attractive targets for the design of inhibitors (Mollazadeh et al., 2018).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10587429

An inherent limitation of the current model is that patient derived xenograft tumors cannot be directly transplanted orthotopically due to the limited space in the site of administration (tibia).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10919056

Clinical nomogram. (

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Clinical", "nomogram", ".", "(" ] } ]

PMC11507371

To verify this in the context of the utilised cell lines and plasma setup of this study, the cell viability was assessed after exposure to plasma.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11047729

Tocotrienol and ferulic acid work synergistically and greatly decrease hTERT expression .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tocotrienol", "and", "ferulic", "acid", "work", "synergistically", "and", "greatly", "decre...

PMC10606998

As a comparison of Figure 3a,b indicates, according to the Resazurin assay results, the radiosensitization effect is more pronounced in the Gl-Tr culture, suggesting a specificity of cell lines to the action of gamma irradiation in the presence of SPIONs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6034753

GST-Apoptin was used against MSB-1 lysate and (B) GST-Meq (1–170) against induced U2OS-Apoptin lysate.

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "GST-Apoptin", "was", "used", ...

PMC11758416

The authors declare no competing interests.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "authors", "declare", "no", "competing", "interests", "." ] } ]

PMC10877303

Fig. 7e indicates that most residues had RMSF values lower than 2.5 Å, with minor fluctuations, signifying the stability of the complexes .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11763764

Therefore, we propose to further explore the potential of FGFR4 inhibitors in targeting recurrent ovarian cancers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "propose", "to", "fu...

PMC9532503

The association (ka), dissociation (kd) constants, and binding affinity (KD) data were analyzed using Biacore T200 evaluation software.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11224020

We conclude that upregulation of both cell motility and CCR7 expression in DCs confined at a height of 3 µm relies on the activity of the cPLA2 enzyme.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11615101

Both cell lines (RAFLS and SW982) were cultured in 96-well culture plates and treated with different doses of TNF-α (1, 5, 10, 20, and 40ng/ml)/α-Taxilin (0, 6.25, 12.5, 25, 50, and 100ng/ml).

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...

PMC11721587

Previous studies showed that forced dimerization of Fu through a coiled-coil (CC) domain from GCN4 (CC-Fu) is sufficient to induce its kinase activation (26, 28).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11119602

Although the association of TG2 with membrane structures is not completely understood, several studies have advanced the idea that TG2 can interact with specific membrane-associated proteins during autophagy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

For eligible patients, standard treatment includes intensive chemotherapy during induction, followed by consolidative chemotherapy or stem cell transplantation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "eligible", "patients"...

PMC9429973

Our data highlight the significant morbidity and mortality burden incurred by patients with MPN-SVT, including a substantially lower rate of re-canalisation compared to a recent meta-analysis of all patients with SVT and high rates of thrombosis recurrence.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11127909

Hence, there is an urgent need to comprehend the mechanism underlying drug resistance in OS and to seek novel strategies for effective treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11244823

Cellular extract expressing gD1(402)-nLuc-V5-H6X and media supernatant of cells expressing gD1(83)-nLuc-V5-H6X were migrated in duplicated in SDS-polyacrylamide gels (SDS-PAGE) as described previously .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10158546

Specifically, through repeated measurements of amyloid seeding activity in 6-week time course experiments, we failed to observe replication of MM1 and VV2 type sCJD, or RML and 263K rodent adapted scrapie.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10114490

Cells were expanded and Dox response (GFP-expression as surrogate marker) re-validated after thawing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "expanded", "and", "Dox", "response", "(", ...

PMC11515150

With regard to survival and proliferation in vivo, engineered anti-CD19 CAR-NK cells with IL-15 and inducible caspase-9 had successfully entered phase II clinical trial (NCT03056339) and the overall response rate (ORR) was up to 73% (8/11) without obvious toxic effects .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11650848

Functional consequences of altered methylation were examined in cultured cells with mutations or by inhibition of the main DNA methyltransferases.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Functional", "consequences", ...

PMC10747160

More concerningly, the most recent Omicron strains display numerous mutations in their spike protein sequences, which have allowed them to establish breakthrough infections in patients who have received multiple booster doses of COVID-19 vaccines .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10588957

The effect of DATS on the cell viability of HepG2. ( *

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "DATS", "on", "the", "cell", "viability", "of", ...

PMC2777936

This may be caused by a difference in the stability or effectiveness of the individual siRNA species or possibly a difference in the rate at which they silence their gene targets.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...