OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11502327	Grape seed procyanidin (GSP) is a natural polyphenol with good antioxidant properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Grape", "seed", "procyanidin", "(", "GSP", ")", "is", "a", ...
PMC8097906	Notably, during the migration assay fibroblasts were cultivated in specific fibroblast medium and not in the charcoal treated medium used for the cancer cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11472569	Recent studies have identified a functional role for EVs in communication between cancer and immune cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "identified", "a", "functi...
PMC10936243	Because sometimes if there is under-pad also it may tear or overturn” [D122].Most of them stated that the use of bedding usually depended on the type of medical condition or surgical procedure each cat was undergoing (n = 7/20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6034753	Alternatively, aggregation of the protein in these cells may inhibit its effectiveness .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alternatively", ",", "aggregation", "of", "the", "protein", "in", "these", ...
PMC11568601	BiP, a protein frequently overexpressed in several types of cancer, has been demonstrated to be an ER stress detector that directly binds to the UPR activator proteins, IRE1 and PERK, leading to UPR activation [12–14].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11546117	P-gp is expressed in different tissues including human breast tissue, although the downregulation of P-gp during lactation has been shown .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P-gp", "is", "exp...
PMC11621565	The 2-ΔΔCT method evaluated relative gene expression, with GADPH as the normalisation reference gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "2-ΔΔCT", "method", "evaluated", "relative", "gene", ...
PMC10850553	Total cell lysates were then prepared subjected to western blot analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "cell", "lysates", "were", "then", "prepared", "subjected", "to", "western", ...
PMC11755467	Use the RNA Single Fold option.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Use", "the", "RNA", "Single", "Fold", "option", "." ] } ]
PMC11739670	Peptide‐specific CD8 T‐cell clones were generated from PBMCs from healthy individuals with at least one copy of the relevant HLA class I allele, as previously described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3675084	Cells were plated at 1000–2500 cells/well in 100 µL of complete medium in 96-well plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "plated", "at", "1000–2500", "cells/well", ...
PMC10831439	ns p>0.05, p≤0.05, p≤0.01, p≤0.001, **p≤0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ns", "p>0.05", ",", "*...
PMC10891340	The recombinant DPV strain expressing green fluorescent protein (DPV-GFP) was constructed by the research center.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "recombinant", "DPV", "strain", "expressing...
PMC11490153	The stretching vibration at 2923 and 2856 cm was attributed to C-H, and the vibration at 1730 was related to the carbonyl group in EO, tween 20, and alginate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8956657	Mutations within the NLS region dramatically alter the mechanism of binding, which reverts to the canonical P2 Lys binding mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutations", "within", ...
PMC11756514	Thus, neither of the two tested CTLs can recognize encapsulated or non-capsulated S. pneumoniae strains.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "neither", "of", "the", "two", "test...
PMC11746948	To solidify the evidence that APT2 is a critical regulator of GPX4 depalmitoylation, thereby impacting cellular susceptibility to ferroptosis, we individually silenced APT2 and other depalmitoylases, including protein acyltransferase APT1 and the abhydrolase domain-containing proteins known to mediate protein depalmito...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The majority of patients had severe lung damage: CT 2 st. -	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "majority", "of", "patients", "had", "severe", "lung", "damage", ...
PMC5941560	This list of likely damaged genes was used to probe selected gene set databases from MSigDB .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "list", "of", "likely", "damaged", "genes", ...
PMC9429973	Aims: We hypothesized that inhibition of ATR may be useful in patients with MDS or CMML, particularly those who harbor SF gene mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	As a result, the Saudi Ministry of Health has acknowledged the need for a national SCD registry to serve as valuable resource for real-world data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11658074	To compare the differences between AT-EVs and ADSC-EVs, we used a proximity barcoding assay (PBA) to analyze the surface proteins on individual particles of these two types of EVs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	One relevant gene, which has not escaped our attention, was PNMA1 that codes the paraneoplastic Ma1 antigen a truly specific neuronal protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	These patients were further randomly divided into 1) a derivation (80%) cohort of 205 patients and 2) a test (20%) cohort of 51 patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11063646	Prolonged radiation exposure, chemical contact, and frequent injury lead to the development of skin cancer (Watson et al., 2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10470467	Therefore, the application potential of the signature in immunotherapy deserves further study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "application", "potential", "of", "the", "signature...
PMC11015054	Immunohistochemistry of paraffin‐embedded subcutaneous tumor tissues from nude mice showed larger necrotic areas in tumor sections from both SMMC‐7721 and HepG2 cell lines with METTL5‐sh versus negative control by HE staining (Figure 5I,J).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "B-CellLine"...
PMC11252033	Total proteins extracted from the cells were quantified with Bradford reagent (Merck Life Science, Milan, Italy).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "proteins", "extract...
PMC11764090	This finding contrasts with the common belief that the reduction in growth caused by abiotic factors is typically attributed to a combination of decreased cell production and reduced mature cell size .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11126803	We first hypothesize that ERβ may regulate ZEB1 via promoter regulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "first", "hypothesize", "that", "ERβ", "may", "regulate", "ZEB1", "via", "promot...
PMC9164404	The results showed that within 12 h, 80%, 10% and 8% of Pt drugs were released in sodium ascorbate (NaVc) aqueous solution, acetate buffer solution, and PBS, respectively, indicating Pt drugs could be rapidly released under the reductive environment (Fig. 1E).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6114978	Anti-LATS2 (rabbit polyclonal, catalog# ab70565) utilized for immunohistochemistry (1:100) was obtained from Abcam (Cambridge, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Interestingly, although Axi- vs. Tisa-cel did not confer different outcomes for patients with 0-1 risk factors (p=0.47), Axi-cel led to significantly improved PFS compared to Tisa-cel in patients with 2-4 risk factors (p<0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10654497	and (H) show significant differences in immune checkpoints and HLA cells between patients with different subtypes. “-”	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "and", "(", "H", ...
PMC11742431	The results emerged that the expression level of Survivin protein gradually decreased with time under the treatment of KVN or K14N, which showed a gradual decrease of fluorescence intensity in the cytoplasm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8728081	Further, from the ROS study, it was observed that there were no significant changes in the reactive oxygen species between control and intervention groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9143157	These findings suggested that the release of free THP is necessary for P-THP to exert is effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggested", "that", "the", ...
PMC8382973	The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973	At loss of MRD negativity in arm A or at PD in arm B, second line treatment will be carfilzomib, dexamethasone and daratumumab until progressive disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4369959	Thus, zerumbone acts as an antiangiogenic and antitumor drug in the treatment of gastric cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "zerumbone", "acts", "as", "an", "an...
PMC11528603	Various compounds obtained from plants of Annonaceae family have demonstrated potential anticancer activities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Various", "compounds", "obtained", "from", "plants", "of", "Annonaceae", "f...
PMC10545062	It is also unclear if a positive response to fluid administration in terms of either BP or CO augmentation equates to the need for fluid administration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11742431	Subsequently, the expression levels of EGFP proteins in UMUC‐3‐EGFP cells treated with the additional addition of MG132 (proteasome inhibitor) or Baf (lysosomal and autophagy pathway inhibitor) were examined by fluorescence microscopy (Figure S3) and western blot (Figure 1G), and the results implied that RVL and R14L d...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754436	Western blotting.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Western", "blotting", "." ] } ]
PMC11388384	Furthermore, if SCUBE1 physically protected SHH from an extracellular protease, cells should show a higher apparent sensitivity to SHH when treated with SCUBE1; however, SCUBE1 did not affect the SHH response threshold, suggesting that SCUBE1 did not biochemically stabilize SHH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11406030	Consequently, it was concluded that LMTK3 staining, particularly in the nucleus, exhibited strong intensity and varied across histotypes but not with patient age or tumor stage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11549612	The observed hypomethylation of BOLA1, BOLA2, and BOLA3 genes across cell lines and TCGA datasets sheds light on potential regulatory mechanisms contributing to their abnormal up-regulation in KIRC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9398137	Statistical significance: *, 5% simultaneous significance level; NS, not statistically significant, for details see Supplementary Materials and Methods.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11185260	Transcriptional changes in genes related to cancer progression were tested by RT-qPCR in intracranial BT-12 tumors harvested at 72h after a single injection of scL-SMARCB1 nanocomplex (30µg DNA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306331	We show that light-based dissolution is sufficient to partially revert aberrant FUS-CHOP gene expression within 6 hours, suggesting a direct role of FUS-CHOP phase separation in gene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676670	The applied PCR conditions were as follows: reaction volume, 25 μL; DNA input, 15 ng; Encyclo Plus PCR kit (Evrogen, Moscow, Russia); and each primer at a final concentration of 5 pM. Sanger sequencing was carried out according to the manufacturer’s protocol with the BigDye Terminator v3.1 Kit (Applied Biosystems/Therm...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806613	Images were captured using confocal microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "were", "captured", "using", "confocal", "microscopy", "." ] } ]
PMC11799978	Similarly, the phosphate buffer was added to the same volume as the NaHCO3 solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "the", "phosphate", "buffer", "was", "adde...
PMC11768927	Consistent with this, Ahmed et al. demonstrated that mice infected with rM51R-M, a recombinant virus encoding the M51R mutation, exhibited an enhanced immune response alongside reduced neurotoxicity when compared to wild-type (WT) VSV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10969097	The extracts were stored at −86 °C and lyophilised at −110 °C to obtain dry samples .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "extracts", "were", "stored", "a...
PMC11786767	Second, to date, Ki-67 homologs have only been detected in vertebrates (48).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Second", ",", "to", "date", ",", "Ki-67", "homol...
PMC11509224	For instance, the compound (−)-agelamide D (43) exhibited cytotoxic activity against L5178Y mouse lymphoma cells and, in another activity evaluation model, demonstrated cytotoxic activity against Hep3B cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11266100	First, the luciferase-pcDNA3 plasmid electrotransfection efficiency of the model CHO-K1 cell line with three different composition EP buffers was tested (No. 1, 2, and 5) (Figure 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	Application of DAMGO induced a robust decrease in FRET emission ratio by about 6% (mean ± SEM; n = 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Applica...
PMC11394227	In the presence of puromycin, the caspase-3 activity of CHO-PAb and CHO-PAb-QS cells was 15.86 μmol/mg and 11.32 μmol/mg, respectively, and the caspase-3 activity of CHO-PAb-QS cells was 28.6% lower than that of CHO-PAb cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502327	According to the National Cancer Institute, 213 proteins are shared across 60 tumor cell lines from nine different cancers (93).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accordi...
PMC9541067	b Quantitative analysis to (a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Quantitative", "analysis", "to", "(", "a", ")", "." ] } ]
PMC11279598	Consequently, efforts to dissect specific chemical constituents with a given biological effect may prove futile.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "efforts", "to", "dissect", "speci...
PMC8164677	The better interaction of wedelolactone than standard is evident in the case of Brd1 which can be possibly attributed to stronger H-bonding with PHE: A 26 (Figure 8A and B)(Figure 7C and B).Table 3Binding Energy (kcal/mol) and Post-Dock Analysis of the Best Pose of Wedelolactone with Hepatocyte Growth Factor Receptor (...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699465	We found the nuclear localization of TMEM199.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "the", "nuclear", "localization", "of", "TMEM199", "." ] } ]
PMC11525293	Two bands of the CRBN protein are evident: °stays for endogenous CRBN, *for transfected CRBN that has higher molecular weight due to an HA tag.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670407	g, h Tumor volume and tumor weight were measured and analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", ",", "h", "Tumor", "volume", "and", "tumor", "weight", "were", "measur...
PMC11566417	600 µL of RPMI or CM was added, and tubes were incubated for 1 h at 37°C with 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10957991	To investigate whether the disrupted cellular junctions were associated with alterations in the cellular forces, we performed traction force imaging on epithelial sheets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	These findings contribute to the understanding of the humanistic and psychological burden of RBCT dependency in patients with β-thalassemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "contribute", ...
PMC9581083	During the spread of the international new crown pneumonia epidemic, NRICM101 have been sold in the United States, Singapore, Australia, Canada, the United Kingdom, France, Belgium, Luxembourg, South Africa, Thailand and the Philippines and other countries for clinicians and the public to use correctly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11799978	NIH3T3 and CAFs were placed in six-well plates at a density of 4 × 10 cells/well.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NIH3T3", "and", "CAFs", "were", "placed", "in...
PMC11468365	To identify synergistic drug combinations, there are two main approaches: in vitro and in vivo experimental approach and in silico computational predictive approach .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11803918	The fused nanoparticles were subjected to ultrafiltration to remove debris (Thermo Fisher Scientific).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fused", "nanoparticles", "were", "subjected", "to", ...
PMC9429973	B. Yohannan, F. Cervoni-curet, A. Rios Hematology and Oncology, University of Texas Health Science Center, McGovern Medical School, Houston, United States of America Background: Acute promyelocytic leukemia (APL) is a rare and distinct subtype of acute myeloid leukemia characterized by t(15;17) translocation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727638	The number of cells in the Cell Domes was analyzed by degrading the hydrogel shells with 2.4 U/mL alginate lyase (Sigma-Aldrich) and collecting cells from the Cell Domes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519077	All samples are tested four times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "samples", "are", "tested", "four", "times", "." ] } ]
PMC11727306	It is shown for the first time that low concentrations of abrin toxin up to as high as 1 to 10 ng/mL amplifies superantigen activity in stimulated T-cells, leading to excessive NFAT pathway activation and secretion of cytokines, e.g., interleukin-2 (IL-2) and interferon-γ (INFγ), in a dose-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767793	Still, a significant variability in biological assay outputs hampers the data comparison across laboratories, as well as test reproducibility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Still", ",", "a",...
PMC7553912	The blotted membranes were incubated with goat anti-OSM antibody (diluted at 1:100, Abcam), goat anti-OSMRβ antibody (diluted at 1:500, R&D Systems), goat anti-OPN antibody (diluted at 1:500, Santa Cruz Biotechnology, Santa Cruz, CA), rabbit anti-ANXA1 antibody (diluted at 1:1000, Abcam), rabbit anti-ANXA2 antibody (di...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394112	For statistical analyses and plots, Student’s t-test, log-rank test, or one-way ANOVA were performed using Prism 7 or 9 (GraphPad Software Inc., San Diego, CA, USA) and Sigma Plot v13.0 (Systat Software Inc., San Jose, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604015	However, several studies have reported the expansion of CD7-negative T cells accompanied by the elimination of CD7-positive counterparts during CD7 CAR-T cell therapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11429241	One gene, CDH1, was downregulated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "gene", ",", "CDH1", ",", "was", "downregulated", "." ] } ]
PMC9429973	J. Angus, W. Letton, S. Connolly, J. Bilimoria, C. Martin Jazz Pharmaceuticals, Oxford; Crystallise Ltd., Essex, United Kingdom Background: VOD/SOS is a potentially fatal complication of HCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11661040	A-E) Western blot analysis was employed to detect the expression levels of CGREF1, Cyclin D, p-GSK3β/GSK3β and p-β catenin/β catenin following CGREF1 overexpression and/or inhibition of the Wnt pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10142392	Nanofibers of PCL encapsulated in ampicillin and coated with PCL have been developed using a diluted and partially electrospinnable PCL solution as the shell and a fully electrospinnable PCL solution containing a drug as the core.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755519	Unfortunately, the cited study did not analyze the protein and qualitative and quantitative analyses of the EVs used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unfortunately", ",", "the", "cite...
PMC11621493	Elongation time was set to 3:30 min (∼20–30 s/kb).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Elongation", "time", "was", "set", "to", "3:30", "min", "(", "∼20–30", "s/kb", ...
PMC11467800	Extravasation assays were performed using confocal microscopy (Zeiss LSM 880) with z‐stack and tile‐scan configurations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Extravasation", "assays", "were", "performed", "u...
PMC11697703	In mice, corticospinal and related subcerebral projection neurons are born during mid-corticogenesis (peak at embryonic day (E) 13.5), reside in layer V, project to brainstem and spinal cord, have large soma size, and extend large dendritic arbors with specific branching patterns and apical tufts reaching layer I. Call...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11225860	This cell is representing a failure to progress through G1/S and was seen in approximately 10% of the combination treatment population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "cell...
PMC9429973	A reduction in soluble BCMA was observed in the first cycle of treatment in a majority of patients who responded to teclistamab.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "reducti...
PMC11321678	We then visualized the single‐cell clusters with UMAP (Figure 1B,C,E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then", "visualized", "the", "single‐cell", "clus...
PMC11786767	Therefore, Ki-67 knockdown delays mitotic progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "Ki-67", "knockdown", "delays", "mitotic", "progression", "." ] } ]
PMC11643491	Cells referred to as A375 positive (A375+) were shown to be more aggressive and have higher phagocytic capacity , while A375 negative (A375−) cells were less aggressive and phagocytic, as previously detailed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790971	and are the amplitudes of the respective exponential components, and are the fluorescence lifetimes of the short and long exponential components, respectively, and is a constant offset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540692	For the same reason, NaBu was at all times dissolved ex tempore in PBS to make a 100 mM stock solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the",...
PMC10142392	In summary, although direct comparison between linear block copolymers and star compositions is challenging due to the complexity of controlling all properties, it is important to continue research in this area to determine which structure is best suited for a given application.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711871	The endothelium-dependent vasorelaxation responses were assessed by the addition of cumulative doses of the endothelium-dependent vasodilator acetylcholine (ACh, 10 to 10 M).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11502327

Grape seed procyanidin (GSP) is a natural polyphenol with good antioxidant properties.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Grape", "seed", "procyanidin", "(", "GSP", ")", "is", "a", ...

PMC8097906

Notably, during the migration assay fibroblasts were cultivated in specific fibroblast medium and not in the charcoal treated medium used for the cancer cell lines.

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PMC11472569

Recent studies have identified a functional role for EVs in communication between cancer and immune cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "identified", "a", "functi...

PMC10936243

Because sometimes if there is under-pad also it may tear or overturn” [D122].Most of them stated that the use of bedding usually depended on the type of medical condition or surgical procedure each cat was undergoing (n = 7/20).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6034753

Alternatively, aggregation of the protein in these cells may inhibit its effectiveness .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alternatively", ",", "aggregation", "of", "the", "protein", "in", "these", ...

PMC11568601

BiP, a protein frequently overexpressed in several types of cancer, has been demonstrated to be an ER stress detector that directly binds to the UPR activator proteins, IRE1 and PERK, leading to UPR activation [12–14].

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11546117

P-gp is expressed in different tissues including human breast tissue, although the downregulation of P-gp during lactation has been shown .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P-gp", "is", "exp...

PMC11621565

The 2-ΔΔCT method evaluated relative gene expression, with GADPH as the normalisation reference gene.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "2-ΔΔCT", "method", "evaluated", "relative", "gene", ...

PMC10850553

Total cell lysates were then prepared subjected to western blot analyses.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "cell", "lysates", "were", "then", "prepared", "subjected", "to", "western", ...

PMC11755467

Use the RNA Single Fold option.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Use", "the", "RNA", "Single", "Fold", "option", "." ] } ]

PMC11739670

Peptide‐specific CD8 T‐cell clones were generated from PBMCs from healthy individuals with at least one copy of the relevant HLA class I allele, as previously described .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3675084

Cells were plated at 1000–2500 cells/well in 100 µL of complete medium in 96-well plates.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "plated", "at", "1000–2500", "cells/well", ...

PMC10831439

ns p>0.05, *p≤0.05, **p≤0.01, ***p≤0.001, ****p≤0.0001.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ns", "p>0.05", ",", "*...

PMC10891340

The recombinant DPV strain expressing green fluorescent protein (DPV-GFP) was constructed by the research center.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "recombinant", "DPV", "strain", "expressing...

PMC11490153

The stretching vibration at 2923 and 2856 cm was attributed to C-H, and the vibration at 1730 was related to the carbonyl group in EO, tween 20, and alginate.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8956657

Mutations within the NLS region dramatically alter the mechanism of binding, which reverts to the canonical P2 Lys binding mechanism.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutations", "within", ...

PMC11756514

Thus, neither of the two tested CTLs can recognize encapsulated or non-capsulated S. pneumoniae strains.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "neither", "of", "the", "two", "test...

PMC11746948

To solidify the evidence that APT2 is a critical regulator of GPX4 depalmitoylation, thereby impacting cellular susceptibility to ferroptosis, we individually silenced APT2 and other depalmitoylases, including protein acyltransferase APT1 and the abhydrolase domain-containing proteins known to mediate protein depalmito...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The majority of patients had severe lung damage: CT 2 st. -

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "majority", "of", "patients", "had", "severe", "lung", "damage", ...

PMC5941560

This list of likely damaged genes was used to probe selected gene set databases from MSigDB .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "list", "of", "likely", "damaged", "genes", ...

PMC9429973

Aims: We hypothesized that inhibition of ATR may be useful in patients with MDS or CMML, particularly those who harbor SF gene mutations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9429973

As a result, the Saudi Ministry of Health has acknowledged the need for a national SCD registry to serve as valuable resource for real-world data.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11658074

To compare the differences between AT-EVs and ADSC-EVs, we used a proximity barcoding assay (PBA) to analyze the surface proteins on individual particles of these two types of EVs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11599565

One relevant gene, which has not escaped our attention, was PNMA1 that codes the paraneoplastic Ma1 antigen a truly specific neuronal protein.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

These patients were further randomly divided into 1) a derivation (80%) cohort of 205 patients and 2) a test (20%) cohort of 51 patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11063646

Prolonged radiation exposure, chemical contact, and frequent injury lead to the development of skin cancer (Watson et al., 2024).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10470467

Therefore, the application potential of the signature in immunotherapy deserves further study.

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PMC11015054

Immunohistochemistry of paraffin‐embedded subcutaneous tumor tissues from nude mice showed larger necrotic areas in tumor sections from both SMMC‐7721 and HepG2 cell lines with METTL5‐sh versus negative control by HE staining (Figure 5I,J).

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PMC11252033

Total proteins extracted from the cells were quantified with Bradford reagent (Merck Life Science, Milan, Italy).

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PMC11764090

This finding contrasts with the common belief that the reduction in growth caused by abiotic factors is typically attributed to a combination of decreased cell production and reduced mature cell size .

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PMC11126803

We first hypothesize that ERβ may regulate ZEB1 via promoter regulation.

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PMC9164404

The results showed that within 12 h, 80%, 10% and 8% of Pt drugs were released in sodium ascorbate (NaVc) aqueous solution, acetate buffer solution, and PBS, respectively, indicating Pt drugs could be rapidly released under the reductive environment (Fig. 1E).Fig.

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PMC6114978

Anti-LATS2 (rabbit polyclonal, catalog# ab70565) utilized for immunohistochemistry (1:100) was obtained from Abcam (Cambridge, MA, USA).

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PMC9429973

Interestingly, although Axi- vs. Tisa-cel did not confer different outcomes for patients with 0-1 risk factors (p=0.47), Axi-cel led to significantly improved PFS compared to Tisa-cel in patients with 2-4 risk factors (p<0.001).

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PMC10654497

and (H) show significant differences in immune checkpoints and HLA cells between patients with different subtypes. “-”

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PMC11742431

The results emerged that the expression level of Survivin protein gradually decreased with time under the treatment of KVN or K14N, which showed a gradual decrease of fluorescence intensity in the cytoplasm.

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PMC8728081

Further, from the ROS study, it was observed that there were no significant changes in the reactive oxygen species between control and intervention groups.

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PMC9143157

These findings suggested that the release of free THP is necessary for P-THP to exert is effect.

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PMC8382973

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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PMC9429973

At loss of MRD negativity in arm A or at PD in arm B, second line treatment will be carfilzomib, dexamethasone and daratumumab until progressive disease.

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PMC4369959

Thus, zerumbone acts as an antiangiogenic and antitumor drug in the treatment of gastric cancer.

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PMC11528603

Various compounds obtained from plants of Annonaceae family have demonstrated potential anticancer activities.

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PMC10545062

It is also unclear if a positive response to fluid administration in terms of either BP or CO augmentation equates to the need for fluid administration.

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PMC11742431

Subsequently, the expression levels of EGFP proteins in UMUC‐3‐EGFP cells treated with the additional addition of MG132 (proteasome inhibitor) or Baf (lysosomal and autophagy pathway inhibitor) were examined by fluorescence microscopy (Figure S3) and western blot (Figure 1G), and the results implied that RVL and R14L d...

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PMC11754436

Western blotting.

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PMC11388384

Furthermore, if SCUBE1 physically protected SHH from an extracellular protease, cells should show a higher apparent sensitivity to SHH when treated with SCUBE1; however, SCUBE1 did not affect the SHH response threshold, suggesting that SCUBE1 did not biochemically stabilize SHH.

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PMC11406030

Consequently, it was concluded that LMTK3 staining, particularly in the nucleus, exhibited strong intensity and varied across histotypes but not with patient age or tumor stage.

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PMC11549612

The observed hypomethylation of BOLA1, BOLA2, and BOLA3 genes across cell lines and TCGA datasets sheds light on potential regulatory mechanisms contributing to their abnormal up-regulation in KIRC.

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PMC9398137

Statistical significance: *, 5% simultaneous significance level; NS, not statistically significant, for details see Supplementary Materials and Methods.

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PMC11185260

Transcriptional changes in genes related to cancer progression were tested by RT-qPCR in intracranial BT-12 tumors harvested at 72h after a single injection of scL-SMARCB1 nanocomplex (30µg DNA).

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PMC11306331

We show that light-based dissolution is sufficient to partially revert aberrant FUS-CHOP gene expression within 6 hours, suggesting a direct role of FUS-CHOP phase separation in gene expression.

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PMC11676670

The applied PCR conditions were as follows: reaction volume, 25 μL; DNA input, 15 ng; Encyclo Plus PCR kit (Evrogen, Moscow, Russia); and each primer at a final concentration of 5 pM. Sanger sequencing was carried out according to the manufacturer’s protocol with the BigDye Terminator v3.1 Kit (Applied Biosystems/Therm...

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PMC11806613

Images were captured using confocal microscopy.

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PMC11799978

Similarly, the phosphate buffer was added to the same volume as the NaHCO3 solution.

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PMC11768927

Consistent with this, Ahmed et al. demonstrated that mice infected with rM51R-M, a recombinant virus encoding the M51R mutation, exhibited an enhanced immune response alongside reduced neurotoxicity when compared to wild-type (WT) VSV.

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PMC10969097

The extracts were stored at −86 °C and lyophilised at −110 °C to obtain dry samples .

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PMC11786767

Second, to date, Ki-67 homologs have only been detected in vertebrates (48).

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PMC11509224

For instance, the compound (−)-agelamide D (43) exhibited cytotoxic activity against L5178Y mouse lymphoma cells and, in another activity evaluation model, demonstrated cytotoxic activity against Hep3B cells.

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PMC11266100

First, the luciferase-pcDNA3 plasmid electrotransfection efficiency of the model CHO-K1 cell line with three different composition EP buffers was tested (No. 1, 2, and 5) (Figure 4A).

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PMC11806106

Application of DAMGO induced a robust decrease in FRET emission ratio by about 6% (mean ± SEM; n = 8).

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PMC11394227

In the presence of puromycin, the caspase-3 activity of CHO-PAb and CHO-PAb-QS cells was 15.86 μmol/mg and 11.32 μmol/mg, respectively, and the caspase-3 activity of CHO-PAb-QS cells was 28.6% lower than that of CHO-PAb cells.

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PMC11502327

According to the National Cancer Institute, 213 proteins are shared across 60 tumor cell lines from nine different cancers (93).

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PMC9541067

b Quantitative analysis to (a).

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PMC11279598

Consequently, efforts to dissect specific chemical constituents with a given biological effect may prove futile.

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PMC8164677

The better interaction of wedelolactone than standard is evident in the case of Brd1 which can be possibly attributed to stronger H-bonding with PHE: A 26 (Figure 8A and B)(Figure 7C and B).Table 3Binding Energy (kcal/mol) and Post-Dock Analysis of the Best Pose of Wedelolactone with Hepatocyte Growth Factor Receptor (...

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PMC11699465

We found the nuclear localization of TMEM199.

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PMC11525293

Two bands of the CRBN protein are evident: °stays for endogenous CRBN, *for transfected CRBN that has higher molecular weight due to an HA tag.

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PMC11670407

g, h Tumor volume and tumor weight were measured and analyzed.

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PMC11566417

600 µL of RPMI or CM was added, and tubes were incubated for 1 h at 37°C with 5% CO2.

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PMC10957991

To investigate whether the disrupted cellular junctions were associated with alterations in the cellular forces, we performed traction force imaging on epithelial sheets.

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PMC9429973

These findings contribute to the understanding of the humanistic and psychological burden of RBCT dependency in patients with β-thalassemia.

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PMC9581083

During the spread of the international new crown pneumonia epidemic, NRICM101 have been sold in the United States, Singapore, Australia, Canada, the United Kingdom, France, Belgium, Luxembourg, South Africa, Thailand and the Philippines and other countries for clinicians and the public to use correctly.

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PMC11799978

NIH3T3 and CAFs were placed in six-well plates at a density of 4 × 10 cells/well.

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PMC11468365

To identify synergistic drug combinations, there are two main approaches: in vitro and in vivo experimental approach and in silico computational predictive approach .

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PMC11803918

The fused nanoparticles were subjected to ultrafiltration to remove debris (Thermo Fisher Scientific).

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PMC9429973

B. Yohannan, F. Cervoni-curet, A. Rios Hematology and Oncology, University of Texas Health Science Center, McGovern Medical School, Houston, United States of America Background: Acute promyelocytic leukemia (APL) is a rare and distinct subtype of acute myeloid leukemia characterized by t(15;17) translocation.

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PMC11727638

The number of cells in the Cell Domes was analyzed by degrading the hydrogel shells with 2.4 U/mL alginate lyase (Sigma-Aldrich) and collecting cells from the Cell Domes.

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PMC11519077

All samples are tested four times.

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PMC11727306

It is shown for the first time that low concentrations of abrin toxin up to as high as 1 to 10 ng/mL amplifies superantigen activity in stimulated T-cells, leading to excessive NFAT pathway activation and secretion of cytokines, e.g., interleukin-2 (IL-2) and interferon-γ (INFγ), in a dose-dependent manner.

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PMC11767793

Still, a significant variability in biological assay outputs hampers the data comparison across laboratories, as well as test reproducibility.

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PMC7553912

The blotted membranes were incubated with goat anti-OSM antibody (diluted at 1:100, Abcam), goat anti-OSMRβ antibody (diluted at 1:500, R&D Systems), goat anti-OPN antibody (diluted at 1:500, Santa Cruz Biotechnology, Santa Cruz, CA), rabbit anti-ANXA1 antibody (diluted at 1:1000, Abcam), rabbit anti-ANXA2 antibody (di...

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PMC11394112

For statistical analyses and plots, Student’s t-test, log-rank test, or one-way ANOVA were performed using Prism 7 or 9 (GraphPad Software Inc., San Diego, CA, USA) and Sigma Plot v13.0 (Systat Software Inc., San Jose, CA, USA).

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PMC11604015

However, several studies have reported the expansion of CD7-negative T cells accompanied by the elimination of CD7-positive counterparts during CD7 CAR-T cell therapy .

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PMC11429241

One gene, CDH1, was downregulated.

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PMC9429973

J. Angus, W. Letton, S. Connolly, J. Bilimoria, C. Martin Jazz Pharmaceuticals, Oxford; Crystallise Ltd., Essex, United Kingdom Background: VOD/SOS is a potentially fatal complication of HCT.

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PMC11661040

A-E) Western blot analysis was employed to detect the expression levels of CGREF1, Cyclin D, p-GSK3β/GSK3β and p-β catenin/β catenin following CGREF1 overexpression and/or inhibition of the Wnt pathway.

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PMC10142392

Nanofibers of PCL encapsulated in ampicillin and coated with PCL have been developed using a diluted and partially electrospinnable PCL solution as the shell and a fully electrospinnable PCL solution containing a drug as the core.

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PMC11755519

Unfortunately, the cited study did not analyze the protein and qualitative and quantitative analyses of the EVs used.

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PMC11621493

Elongation time was set to 3:30 min (∼20–30 s/kb).

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PMC11467800

Extravasation assays were performed using confocal microscopy (Zeiss LSM 880) with z‐stack and tile‐scan configurations.

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PMC11697703

In mice, corticospinal and related subcerebral projection neurons are born during mid-corticogenesis (peak at embryonic day (E) 13.5), reside in layer V, project to brainstem and spinal cord, have large soma size, and extend large dendritic arbors with specific branching patterns and apical tufts reaching layer I. Call...

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PMC11225860

This cell is representing a failure to progress through G1/S and was seen in approximately 10% of the combination treatment population.

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PMC9429973

A reduction in soluble BCMA was observed in the first cycle of treatment in a majority of patients who responded to teclistamab.

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PMC11321678

We then visualized the single‐cell clusters with UMAP (Figure 1B,C,E).

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PMC11786767

Therefore, Ki-67 knockdown delays mitotic progression.

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PMC11643491

Cells referred to as A375 positive (A375+) were shown to be more aggressive and have higher phagocytic capacity , while A375 negative (A375−) cells were less aggressive and phagocytic, as previously detailed.

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PMC11790971

and are the amplitudes of the respective exponential components, and are the fluorescence lifetimes of the short and long exponential components, respectively, and is a constant offset.

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PMC8540692

For the same reason, NaBu was at all times dissolved ex tempore in PBS to make a 100 mM stock solution.

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PMC10142392

In summary, although direct comparison between linear block copolymers and star compositions is challenging due to the complexity of controlling all properties, it is important to continue research in this area to determine which structure is best suited for a given application.

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PMC11711871

The endothelium-dependent vasorelaxation responses were assessed by the addition of cumulative doses of the endothelium-dependent vasodilator acetylcholine (ACh, 10 to 10 M).

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