OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10033453	Plasmid pVSV-XN2 was a gift from Richard Vile (Mayo Clinic Rochester, Rochster, MN, USA) encoding for full-length antisense VSV Indiana genome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10968586	In glioblastoma cell line T98G, 277.5 μM and 555 μM OLE for 24 h diminished cell viability in a dose-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens"...
PMC8358176	After 30 days, the expression fold changes of TNF in MWCNT- and SWCNT-treated rats were 1.59 ± 0.74 and 2.3 ± 0.97, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC4685341	During the scale up of a cell culture process for a late stage project we observed that the cell age might influence the non-fucose level and thus the ADCC of the recombinant monoclonal antibody negatively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9388315	According to the results, the amount of Cinnamaldehyde in the prepared extract was 26 μg/ml.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "results", ",", "the", ...
PMC11745823	The engineered shRNAs preferentially target the mRNA of RIT1 and c‐Myc, promoting their breakdown and so reducing their production in the infected cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9000591	However, to date, only a limited number of herbal medicines have been officially approved for therapeutic purposes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "to", "date", ...
PMC11666785	The results clearly indicate the negligible effect of photobleaching for the duration of data acquisition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "clearly", "indicate", "the", "negligible", ...
PMC10919056	Analysis of the Difference in Immune Score between high-RS and low-RS Groups. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Analysis", "of", "the", "Difference", "in", "Immune", "Score", "between", ...
PMC9429973	The best response was defined as the deepest response during the follow-up.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "best", "response", "was", "defined", "as", "the", "deepest", "response", ...
PMC11755519	They can also transfer information between cancer cells and other types of cells, such as stromal cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "can", "also", "transfer", "inf...
PMC11727145	With the addition of insulin (Figure 4, #4–5), a slight increase in cell attachment and keratinocyte invagination was noted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11740508	Combination treatment reduced colonies to ~ 60% of controls, while in their SUM149PT controls, colonies were reduced to about 30% of controls In Tala titration studies, Deci addition reduced colony formation at each Tala dose in all M231 variants (Fig. 4E–G), and potently in SUM149PT -where Tala doses could be reduced ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11481779	Another concept used is convolutional encoder-decoder architectures, which include Akita and Orca .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "concept", "used", "is", "convolutional", "encoder-decoder", "architect...
PMC11400680	Additionally, advanced deep learning methods, namely segment anything model (SAM) (2023) (23), had recently demonstrated impressive results in segmentation tasks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11628309	Additionally, the overexpression of α-synuclein and its A30P mutant increases susceptibility to compounds such as dopamine and L-DOPA, decreasing viability by up to 57% for the WT protein and up to 63% for the A30P mutant (Bisaglia et al., 2010).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6222726	It has imparipinnate leaves of coriaceous texture with 3 to 13 leaflets, 6.5 cm long and 2.3 cm wide, and margin roughly serrated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11675244	Upregulated Wnt signaling enhances the stemness of both normal and cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Upregulated", "Wnt", "signaling", "enhances", "the", "stemness", "of", "both", "...
PMC11513011	After 48 h, apoptotic cells were analyzed by flow cytometry using the Annexin V-FITC Apoptosis Detection Kit (Nacalai Tesque, Kyoto, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11740907	Because of the low quantity of data points, it was not possible to create a kinetic model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Because", "of", "the", "low", "quantit...
PMC11791264	The migration rate was calculated as follows: % of scratch closure = [(initial wound length) − (wound length at 24/72 h)]/(initial wound length) × 100.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	Exatecan mesylate (DX-8951f) (57) is a water-soluble CPT derivative with stronger TOPO-I inhibitory and antitumor activity than other CPT analogs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11279397	In vivo mouse models have also confirmed that these compounds have therapeutic effects on virus-infected mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vivo", "mouse", "models", "have", "also", ...
PMC11711127	Unstable cell-cell synapses have been reported in Ag-specific systems between human Tregs and cognate APCs (136) and mouse Tregs with DCs (137).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC2614415	Furthermore, we demonstrated the pan-Aurora inhibitor VE-465 can synergize with paclitaxel to induce apoptosis and is a potent killer of taxane-sensitive and resistant ovarian cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7185206	These results suggest that ADAM10 and ADAM17 cleave surface PD-L1 to produce sPD-L1, which in turn induces CD8 + T cell apoptosis and prevents PD-(L)1 inhibitor function (Figure 4(e)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8345486	Cells were incubated with DCF-DA in HBSS (10 μM, 3 × 10 cells in 0.3 mL, 30-min incubation at 37 °C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	At the last follow-up, the proportion of returning to society was comparable between the HID and ISD groups, showing 78.0% versus 84.6% among children and 74.6% versus 81.2% among adults.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8336407	TBA assay (TBA test) is widely used to assess the products of lipid peroxidation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TBA", "assay", "(", "TBA", "test", ")", "is", ...
PMC11413393	n = 10 mice/group (RCC243) and n = 5 mice/group (786-0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "10", "mice/group", "(", "RCC243",...
PMC11441402	For adherent cells, medium was removed from cells and 100 µL of 0.5 mg/mL MTT (Sigma-Aldrich, Merck, Germany) made up in RPMI medium was added to wells and incubated for 3 h at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10253973	The transformation of the carbohydrate part of the compounds 7–9 (Figure 3) increased their water solubility, and all complexes exhibited high cytotoxicity towards human ovarian cancer (CH1), colorectal cancer (SW480), lung cancer (A549), melanoma proteoglycan cells (Me300), glioblastoma (LNZ308) and cisplatin resistan...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	Because our goal was to identify evolutionarily conserved mechanisms of host immunity, we took advantage of an existing commercial human prey library and conducted two independent yeast two-hybrid (Y2H) screens using IpaH4 bait.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	The C-terminus was shortened after T370 (violet) or T364 (gray, short), and an mTurq2 was appended.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "C-ter...
PMC11599565	Results are representative of n = 3 independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "representative", "of", "n", "=", "3", "independent", "experiments", "." ] } ]
PMC11711063	The association between altered characteristics of the tumor matrisome and cancer outcomes has also been shown. ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "association", "between", "altered", "chara...
PMC11615743	As a result, the high off‐rate of the monovalent aptamer and the slow off‐rate of the bivalent aptamer further increased the positive‐to‐negative ratio.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10882807	Finally, two pathologists evaluated all stained sections independently.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "two", "pathologists", "evaluated", "all", "stained", "sections", "independently", "." ]...
PMC5925824	By flow cytometry LY3300054 was shown to specifically bind to the surface of the PD-L1-positive (H292, HCC827) but not the PD-L1–negative A204 cell lines (Additional file 1: Figure S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine"...
PMC11335267	In addition, the expected decrease in adiponectin mRNA expression in vWAT induced by HFD was less pronounced in Alx3-deficient mice than in controls (Fig. 2O).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11569208	The targeting of kinases using small molecular inhibitors to favor dephosphorylated states has been shown to influence interferon signalling and resistance to infection in a multitude of ways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Two patients were previously diagnosed with a multiple myeloma, one patient had a T lymphoma in complete remission, and one patient had a monoclonal gammapathy of undetermined significance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637276	Vectashield antifade mounting medium from VECTOR laboratories.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vectashield", "antifade", "mounting", "medium", "from", "VECTOR", "laboratories", "." ] } ]
PMC7433824	İK involved in the cell culture experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "İK", "involved", "in", "the", "cell", "culture", "experiments", "." ] } ]
PMC11731614	Silver stain was performed on gels using the Pierce™ Silver Stain Kit (ThermoFisher Scientific 24612) according to the manufacturer’s protocol with a development time of 90 s. Dynamic light scattering.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767582	C NMR (101 MHz, CDCl3) δ 153.2, 149.6, 148.7, 138.2, 137.4, 132.4, 132.0, 121.3, 118.8, 111.3, 111.2, 111.1, 102.8, 60.7, 56.0, 55.7, 55.6, 55.6.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In a separate experiment, mice were sacrificed at day 49 post-huPBMC injection (after 4 weeks of antibody treatment) for tissue analysis (liver, lung, skin and bone marrow) of immune cell infiltration (T cells and macrophages), inflammation and/or fibrosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6222726	The leaves are 3 to 8 cm long and have 7 to 35 small, linear, and glabrous leaflets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "leaves", "are", ...
PMC9429973	R. Garcia-Vicente, A. Rodriguez-Garcia, R. Gomez-Gordo, A. Ortega-Hernandez, R. Ancos, S. Serrano, J. Modrego, A. Leivas, A. Valeri, A. Jimenez-Ubieto, J. M. Sanchez-Pina, M. L. Paciello, D. Gomez-Garre, J. Martinez-Lopez, M. Linares Department of Translational Hematology, Research Institute Hospital 12 de Octubre (i+1...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698	Bioinformatics predicted that miR-211-5p might be the downstream target of circUSP10, and RIP and dual-luciferase experiments proved that circUSP10 could act as a sponge by adsorbing miR-211-5p.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763111	In addition, GSEA analyses demonstrated that LLT1 overexpression led to positive enrichment in pathways related to cytokine and cytokine-receptor interactions, as well as cytokine production (Fig. 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8701144	Fluorescent images were acquired with a Zeiss Elyra PS1 microscope system (Carl Zeiss Microscopy, Jena, Germany) using standard filters sets and laser lines with a Plan-APOCHROMAT 63x 1.4 NA oil objective.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We assessed peripheral blood T cell subsets by multiparametric flow cytometry using the following monoclonal antibodies: CD45, CD3, CD4, CD8, CXCR3, CCR6, CCR4, CD25 and CD127.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591052	Following multiple PBST washes, we applied secondary anti-mouse or anti-rabbit antibodies (1:10,000; Sigma-Aldrich, St. Louis, MO, USA) conjugated with horseradish peroxidase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5854676	Figure 4FTIR spectra from (a) MgO; (b) PEG + MgO. FTIR spectra from (a) MgO; (b) PEG + MgO. The dominant peaks in MgO are shown in Fig. 5(a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10919056	Additionally, KEGG enrichment analysis indicated that “neuroactive ligand-receptor interaction”, “cAMP signaling pathway”, “cytokine-cytokine receptor interaction”, “adrenergic signaling pathway in cardiomyocytes”, “GnRH secretion”, and “TGF-beta signaling pathway” were enriched in high-RS population (Figure 7B). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11653168	The consequence of this inhibition is a greater apoptotic rate of STAT3-dependent cancer cells (22).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "consequence", "of", "this", "inhibition", ...
PMC10530622	Indeed, the link between microbiota and lithiasis has been highlighted when authors found an association between antibiotic exposure of children at young age (3–12 months) and nephrolithiasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544771	CPX has been shown to induce cell cycle arrest in the G1/G0 phase in many cell lines, including promyeloid leukemia (HL-60) cells , Chinese hamster ovary cells , human umbilical vein endothelial cells , cervical cancer (HeLa) cells , neuroblastoma cells , rhabdomyosarcoma (Rh30) cells , breast cancer (MDA-MB-231) , acu...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11770130	In brief, the sodium hyaluronate, poloxamer 407 and ultrapure water were mixed, centrifuged and stored in the fridge.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "brief", ","...
PMC9429973	These are a complex group of blood cancers that typically have poor overall survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "are", "a", "complex", "group", "of", "blood", "cancers"...
PMC11731161	After 15 min of incubation in the dark, the samples were subjected to analysis via flow cytometry (Beckman Coulter, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Although the heterogeneity of study populations precluded meta-analyses of outcomes data, consistent improvements in key clinical parameters were widely reported, including reductions in LDH levels, TEs, transfusion dependence and mortality outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074	Despite the need for further in vitro and in vivo experiments to be performed on safety and the involved molecular mechanisms, compound 4 may hold high potential for future development as an anticancer drug.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	estimated life expectancy of less than three months and involvement of the palliative care team (PCT).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "estimated", "life", "expectancy", "of", ...
PMC5574817	Fig. 7 Plasmid map of pCMV6-Neo-hERG (adapted from Origene Technologies, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "7", "Plasmid", "map", "of", "pCMV6-Neo-hERG", "(", "adap...
PMC11244823	Although it is uncertain that the N-terminal epitopes of gD1 addressed in this communication are linked to better protection, we suggest that in future vaccine developments, type-common antigens should be avoided, while a broad range of type-specific antigens should be favored.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683130	The majority of serpins containing(B1-8, B12, B13) in Clade B are expressed in the skin (35).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973	Univariate analysis In multivariate analysis, elevated NLR (>9) (hazard risk [HR] 2.83, 95% confidence interval [CI] 1.75–4.57) was retained as only factor associated with intensive care hospitalization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	The isolated tumor cells and previously established primary glioblastoma cell lines were cultured in DMEM-F12 supplemented with B27 (#17504044, Thermo Fisher), 5 µg/ml Insulin (#I9278, Sigma-Aldrich), 5 µg/ml Heparin (#H4784, Sigma-Aldrich), 20 ng/ml epidermal growth factor (EGF, #AF-100-15, Peprotech) and 20 ng/ml fib...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10772747	The threshold value was determined based on a p-value of 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "threshold", "value", "was", "determined", "based", "on", "a", "p-value", "of",...
PMC11389534	Defective PARP1 UFMylation can lead to excessive degradation of nascent DNA at stalled replication forks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Defective", "PARP1", "UFMylation", "can", "lead", "to", "ex...
PMC10582049	ADH1B CAF markers are prognostic for patients with lung adenocarcinoma at early stages. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ADH1B", "CAF", "markers", "are", "prognostic", "for", "patients", ...
PMC10914904	Similarly, the IFN-stimulated oligoadenylate synthetase (OAS)/RNase L system, which is triggered by cytosolic virus-derived dsRNA, leads to the generation of 2′–5′ oligoadenylates, thereby promoting the dimerization and activation of RNase L, an endonuclease responsible for the widespread degradation of cytoplasmic mRN...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635087	The precipitate was suspended in 15 mL of 180 mM sucrose buffer (20 mM Tris-HCl, 5 mM EGTA, 5 mM MgCl2・6H2O, 5 mM KCl) shielded from light, and gently mixed at 40° for 1 hour.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4355729	The volume of xenografts was serially measured.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "volume", "of", "xenografts", "was", "serially", "measured", "." ] } ]
PMC11321678	Altogether, our analyses provide a comprehensive identification of cis‐regulatory elements’ activity and reveal the regulatory architecture within different molecular subgroups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Altogether", ...
PMC11782780	No. BC2205), Lactate Kit (Cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No.", "BC2205", ")", ",", "Lactate", "Kit", "(", "Cat", "." ] } ]
PMC11301242	Yaming Xi: Conceptualization, Methodology, Writing – review & editing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yaming", "Xi", ":", "Conceptualization", ",", "Methodology", ",", "Writing", "–"...
PMC11285179	Finally, retain 80 μL of the supernatant for subsequent liquid chromatography-mass spectrometry analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "retain", "80", "μL", "of", "the", "supernatant",...
PMC9927933	We first performed an association study using TCGA database containing more than 400 lung cancer cases, and found that overexpression of either UBE2C or UBE2S is correlated with the survival of LUAD patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11359735	For this reason, we sought to confirm the presence of a definitive GPI anchor component (myo-inositol) in CSP by direct chemical means.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6617630	BETi in combination with Pan-HDAC inhibitor had a limited effect on survival of DHL/THL, while combination of BETi and BCL2 inhibitor (ABT-199) had a significant (p < 0.005) inhibitory effect on survival followed by BCL-XL inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739504	Scale bar: 20 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "20", "μm", "." ] } ]
PMC11788920	Therefore, being able to regulate transcription by targeting the PQS with dCas9 promises to be a widely applicable and sequence specific method of transcription regulation, unlike alternative methods (such as small molecules or site-directed mutagenesis), which lack sequence specificity or transience.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8316344	F βTrCP increased the ubiquitination of TFRC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "βTrCP", "increased", "the", "ubiquitination", "of", "TFRC", "." ] } ]
PMC11723947	Interestingly, we observed a significant enrichment of genes downregulated in HP1α-deficient cells among those that define Tex identity (Fig. 3n).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interes...
PMC11763764	The identification of the key molecules in these pathways is a critical step towards developing targeted therapies to improve the clinical outcomes of patients with recurrent ovarian cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987	We reasoned that a weaker association between low promoter variability and broad width than with high entropy may be due to low variable promoters being composed of multiple clusters of TSSs (multi-modal peaks) from independent core promoters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11757131	Of these intermediate products, 3-HIB has attracted widespread attention in recent years (18, 19).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "these", "intermediate", "products", ...
PMC11437637	The data were compared using a two-paired t-test or a two-paired Mann-Whitney U test for normally distributed and non-normally distributed data, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC10778532	RNA sequencing analysis revealed that VHL-C162F mutation upregulates genes involved in hypoxia and epithelial mesenchymal transition (EMT) pathways by comparison with VHL WT cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7504302	On the other hand, studies in human renal cell carcinomas suggest that the functional loss of SETD2 gene, together with other chromatin remodelers, could lead to epigenome aberrations and pathological splicing events, as discussed in further detail below.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10530622	Urinary oxalate excretion was higher in men, in higher body mass index, diabetes, creatinuria and proteinuria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Urinary", "oxalate", "excretion", ...
PMC11411004	All conditions were performed in three independent replicates, and the data are expressed as the mean ± standard deviation (SD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", ...
PMC11628904	Therefore, we next probed for apoptotic death using antibodies against active‐caspase 3 in order to determine whether isotonic medium protects cells from this mode of death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803149	Photos of tumors isolated from mice analyzed on day 20.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Photos", "of", "tumors", "isolated", "from", "mice", "analyzed", "on", "day", "20", "." ...
PMC11704834	It is noteworthy that it has been previously shown that Zeb1 is a critical TF in mediating TLE1-induced silencing of E-cadherin expression and TLE1-mediated EMT in LUAD cells (9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11481779	To account for that, differences between the reference genome and an individual one (obtained by reads from an experiment) can be calculated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Methods: CARDINAL is a two-part, open-label, single-arm study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "CARDINAL", "is", "a", "two-part", ",", "open-label", ",", "single-arm...

PMC10033453

Plasmid pVSV-XN2 was a gift from Richard Vile (Mayo Clinic Rochester, Rochster, MN, USA) encoding for full-length antisense VSV Indiana genome.

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PMC10968586

In glioblastoma cell line T98G, 277.5 μM and 555 μM OLE for 24 h diminished cell viability in a dose-dependent manner.

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PMC8358176

After 30 days, the expression fold changes of TNF in MWCNT- and SWCNT-treated rats were 1.59 ± 0.74 and 2.3 ± 0.97, respectively.

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PMC4685341

During the scale up of a cell culture process for a late stage project we observed that the cell age might influence the non-fucose level and thus the ADCC of the recombinant monoclonal antibody negatively.

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PMC9388315

According to the results, the amount of Cinnamaldehyde in the prepared extract was 26 μg/ml.

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PMC11745823

The engineered shRNAs preferentially target the mRNA of RIT1 and c‐Myc, promoting their breakdown and so reducing their production in the infected cells.

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PMC9000591

However, to date, only a limited number of herbal medicines have been officially approved for therapeutic purposes.

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PMC11666785

The results clearly indicate the negligible effect of photobleaching for the duration of data acquisition.

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PMC10919056

Analysis of the Difference in Immune Score between high-RS and low-RS Groups. (

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PMC9429973

The best response was defined as the deepest response during the follow-up.

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PMC11755519

They can also transfer information between cancer cells and other types of cells, such as stromal cells.

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PMC11727145

With the addition of insulin (Figure 4, #4–5), a slight increase in cell attachment and keratinocyte invagination was noted.

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PMC11740508

Combination treatment reduced colonies to ~ 60% of controls, while in their SUM149PT controls, colonies were reduced to about 30% of controls In Tala titration studies, Deci addition reduced colony formation at each Tala dose in all M231 variants (Fig. 4E–G), and potently in SUM149PT -where Tala doses could be reduced ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11481779

Another concept used is convolutional encoder-decoder architectures, which include Akita and Orca .

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PMC11400680

Additionally, advanced deep learning methods, namely segment anything model (SAM) (2023) (23), had recently demonstrated impressive results in segmentation tasks.

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PMC11628309

Additionally, the overexpression of α-synuclein and its A30P mutant increases susceptibility to compounds such as dopamine and L-DOPA, decreasing viability by up to 57% for the WT protein and up to 63% for the A30P mutant (Bisaglia et al., 2010).

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PMC6222726

It has imparipinnate leaves of coriaceous texture with 3 to 13 leaflets, 6.5 cm long and 2.3 cm wide, and margin roughly serrated.

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PMC11675244

Upregulated Wnt signaling enhances the stemness of both normal and cancer cells.

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PMC11513011

After 48 h, apoptotic cells were analyzed by flow cytometry using the Annexin V-FITC Apoptosis Detection Kit (Nacalai Tesque, Kyoto, Japan).

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PMC11740907

Because of the low quantity of data points, it was not possible to create a kinetic model.

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PMC11791264

The migration rate was calculated as follows: % of scratch closure = [(initial wound length) − (wound length at 24/72 h)]/(initial wound length) × 100.

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PMC10547921

Exatecan mesylate (DX-8951f) (57) is a water-soluble CPT derivative with stronger TOPO-I inhibitory and antitumor activity than other CPT analogs.

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PMC11279397

In vivo mouse models have also confirmed that these compounds have therapeutic effects on virus-infected mice.

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PMC11711127

Unstable cell-cell synapses have been reported in Ag-specific systems between human Tregs and cognate APCs (136) and mouse Tregs with DCs (137).

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PMC2614415

Furthermore, we demonstrated the pan-Aurora inhibitor VE-465 can synergize with paclitaxel to induce apoptosis and is a potent killer of taxane-sensitive and resistant ovarian cancer cells.

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PMC7185206

These results suggest that ADAM10 and ADAM17 cleave surface PD-L1 to produce sPD-L1, which in turn induces CD8 + T cell apoptosis and prevents PD-(L)1 inhibitor function (Figure 4(e)).

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PMC8345486

Cells were incubated with DCF-DA in HBSS (10 μM, 3 × 10 cells in 0.3 mL, 30-min incubation at 37 °C).

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PMC9429973

At the last follow-up, the proportion of returning to society was comparable between the HID and ISD groups, showing 78.0% versus 84.6% among children and 74.6% versus 81.2% among adults.

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PMC8336407

TBA assay (TBA test) is widely used to assess the products of lipid peroxidation.

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PMC11413393

n = 10 mice/group (RCC243) and n = 5 mice/group (786-0).

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PMC11441402

For adherent cells, medium was removed from cells and 100 µL of 0.5 mg/mL MTT (Sigma-Aldrich, Merck, Germany) made up in RPMI medium was added to wells and incubated for 3 h at 37 °C.

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PMC10253973

The transformation of the carbohydrate part of the compounds 7–9 (Figure 3) increased their water solubility, and all complexes exhibited high cytotoxicity towards human ovarian cancer (CH1), colorectal cancer (SW480), lung cancer (A549), melanoma proteoglycan cells (Me300), glioblastoma (LNZ308) and cisplatin resistan...

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PMC11098378

Because our goal was to identify evolutionarily conserved mechanisms of host immunity, we took advantage of an existing commercial human prey library and conducted two independent yeast two-hybrid (Y2H) screens using IpaH4 bait.

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PMC11806106

The C-terminus was shortened after T370 (violet) or T364 (gray, short), and an mTurq2 was appended.

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PMC11599565

Results are representative of n = 3 independent experiments.

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PMC11711063

The association between altered characteristics of the tumor matrisome and cancer outcomes has also been shown. ,

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PMC11615743

As a result, the high off‐rate of the monovalent aptamer and the slow off‐rate of the bivalent aptamer further increased the positive‐to‐negative ratio.

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PMC10882807

Finally, two pathologists evaluated all stained sections independently.

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PMC5925824

By flow cytometry LY3300054 was shown to specifically bind to the surface of the PD-L1-positive (H292, HCC827) but not the PD-L1–negative A204 cell lines (Additional file 1: Figure S1).

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PMC11335267

In addition, the expected decrease in adiponectin mRNA expression in vWAT induced by HFD was less pronounced in Alx3-deficient mice than in controls (Fig. 2O).

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PMC11569208

The targeting of kinases using small molecular inhibitors to favor dephosphorylated states has been shown to influence interferon signalling and resistance to infection in a multitude of ways.

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PMC9429973

Two patients were previously diagnosed with a multiple myeloma, one patient had a T lymphoma in complete remission, and one patient had a monoclonal gammapathy of undetermined significance.

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PMC11637276

Vectashield antifade mounting medium from VECTOR laboratories.

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PMC7433824

İK involved in the cell culture experiments.

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PMC11731614

Silver stain was performed on gels using the Pierce™ Silver Stain Kit (ThermoFisher Scientific 24612) according to the manufacturer’s protocol with a development time of 90 s. Dynamic light scattering.

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PMC11767582

C NMR (101 MHz, CDCl3) δ 153.2, 149.6, 148.7, 138.2, 137.4, 132.4, 132.0, 121.3, 118.8, 111.3, 111.2, 111.1, 102.8, 60.7, 56.0, 55.7, 55.6, 55.6.

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PMC9429973

In a separate experiment, mice were sacrificed at day 49 post-huPBMC injection (after 4 weeks of antibody treatment) for tissue analysis (liver, lung, skin and bone marrow) of immune cell infiltration (T cells and macrophages), inflammation and/or fibrosis.

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PMC6222726

The leaves are 3 to 8 cm long and have 7 to 35 small, linear, and glabrous leaflets.

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PMC9429973

R. Garcia-Vicente, A. Rodriguez-Garcia, R. Gomez-Gordo, A. Ortega-Hernandez, R. Ancos, S. Serrano, J. Modrego, A. Leivas, A. Valeri, A. Jimenez-Ubieto, J. M. Sanchez-Pina, M. L. Paciello, D. Gomez-Garre, J. Martinez-Lopez, M. Linares Department of Translational Hematology, Research Institute Hospital 12 de Octubre (i+1...

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PMC10565698

Bioinformatics predicted that miR-211-5p might be the downstream target of circUSP10, and RIP and dual-luciferase experiments proved that circUSP10 could act as a sponge by adsorbing miR-211-5p.

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PMC11763111

In addition, GSEA analyses demonstrated that LLT1 overexpression led to positive enrichment in pathways related to cytokine and cytokine-receptor interactions, as well as cytokine production (Fig. 4B).

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PMC8701144

Fluorescent images were acquired with a Zeiss Elyra PS1 microscope system (Carl Zeiss Microscopy, Jena, Germany) using standard filters sets and laser lines with a Plan-APOCHROMAT 63x 1.4 NA oil objective.

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PMC9429973

We assessed peripheral blood T cell subsets by multiparametric flow cytometry using the following monoclonal antibodies: CD45, CD3, CD4, CD8, CXCR3, CCR6, CCR4, CD25 and CD127.

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PMC11591052

Following multiple PBST washes, we applied secondary anti-mouse or anti-rabbit antibodies (1:10,000; Sigma-Aldrich, St. Louis, MO, USA) conjugated with horseradish peroxidase.

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PMC5854676

Figure 4FTIR spectra from (a) MgO; (b) PEG + MgO. FTIR spectra from (a) MgO; (b) PEG + MgO. The dominant peaks in MgO are shown in Fig. 5(a).

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PMC10919056

Additionally, KEGG enrichment analysis indicated that “neuroactive ligand-receptor interaction”, “cAMP signaling pathway”, “cytokine-cytokine receptor interaction”, “adrenergic signaling pathway in cardiomyocytes”, “GnRH secretion”, and “TGF-beta signaling pathway” were enriched in high-RS population (Figure 7B). (

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PMC11653168

The consequence of this inhibition is a greater apoptotic rate of STAT3-dependent cancer cells (22).

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PMC10530622

Indeed, the link between microbiota and lithiasis has been highlighted when authors found an association between antibiotic exposure of children at young age (3–12 months) and nephrolithiasis .

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PMC11544771

CPX has been shown to induce cell cycle arrest in the G1/G0 phase in many cell lines, including promyeloid leukemia (HL-60) cells , Chinese hamster ovary cells , human umbilical vein endothelial cells , cervical cancer (HeLa) cells , neuroblastoma cells , rhabdomyosarcoma (Rh30) cells , breast cancer (MDA-MB-231) , acu...

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PMC11770130

In brief, the sodium hyaluronate, poloxamer 407 and ultrapure water were mixed, centrifuged and stored in the fridge.

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PMC9429973

These are a complex group of blood cancers that typically have poor overall survival.

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PMC11731161

After 15 min of incubation in the dark, the samples were subjected to analysis via flow cytometry (Beckman Coulter, USA).

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PMC9429973

Although the heterogeneity of study populations precluded meta-analyses of outcomes data, consistent improvements in key clinical parameters were widely reported, including reductions in LDH levels, TEs, transfusion dependence and mortality outcomes.

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PMC11594074

Despite the need for further in vitro and in vivo experiments to be performed on safety and the involved molecular mechanisms, compound 4 may hold high potential for future development as an anticancer drug.

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PMC9429973

estimated life expectancy of less than three months and involvement of the palliative care team (PCT).

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PMC5574817

Fig. 7 Plasmid map of pCMV6-Neo-hERG (adapted from Origene Technologies, USA).

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PMC11244823

Although it is uncertain that the N-terminal epitopes of gD1 addressed in this communication are linked to better protection, we suggest that in future vaccine developments, type-common antigens should be avoided, while a broad range of type-specific antigens should be favored.

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PMC11683130

The majority of serpins containing(B1-8, B12, B13) in Clade B are expressed in the skin (35).

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PMC9429973

Univariate analysis In multivariate analysis, elevated NLR (>9) (hazard risk [HR] 2.83, 95% confidence interval [CI] 1.75–4.57) was retained as only factor associated with intensive care hospitalization.

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PMC11787355

The isolated tumor cells and previously established primary glioblastoma cell lines were cultured in DMEM-F12 supplemented with B27 (#17504044, Thermo Fisher), 5 µg/ml Insulin (#I9278, Sigma-Aldrich), 5 µg/ml Heparin (#H4784, Sigma-Aldrich), 20 ng/ml epidermal growth factor (EGF, #AF-100-15, Peprotech) and 20 ng/ml fib...

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PMC10772747

The threshold value was determined based on a p-value of 0.05.

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PMC11389534

Defective PARP1 UFMylation can lead to excessive degradation of nascent DNA at stalled replication forks.

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PMC10582049

ADH1B CAF markers are prognostic for patients with lung adenocarcinoma at early stages. (

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PMC10914904

Similarly, the IFN-stimulated oligoadenylate synthetase (OAS)/RNase L system, which is triggered by cytosolic virus-derived dsRNA, leads to the generation of 2′–5′ oligoadenylates, thereby promoting the dimerization and activation of RNase L, an endonuclease responsible for the widespread degradation of cytoplasmic mRN...

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PMC11635087

The precipitate was suspended in 15 mL of 180 mM sucrose buffer (20 mM Tris-HCl, 5 mM EGTA, 5 mM MgCl2・6H2O, 5 mM KCl) shielded from light, and gently mixed at 40° for 1 hour.

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PMC4355729

The volume of xenografts was serially measured.

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PMC11321678

Altogether, our analyses provide a comprehensive identification of cis‐regulatory elements’ activity and reveal the regulatory architecture within different molecular subgroups.

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PMC11782780

No. BC2205), Lactate Kit (Cat.

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PMC11301242

Yaming Xi: Conceptualization, Methodology, Writing – review & editing.

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PMC11285179

Finally, retain 80 μL of the supernatant for subsequent liquid chromatography-mass spectrometry analysis.

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PMC9927933

We first performed an association study using TCGA database containing more than 400 lung cancer cases, and found that overexpression of either UBE2C or UBE2S is correlated with the survival of LUAD patients.

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PMC11359735

For this reason, we sought to confirm the presence of a definitive GPI anchor component (myo-inositol) in CSP by direct chemical means.

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PMC6617630

BETi in combination with Pan-HDAC inhibitor had a limited effect on survival of DHL/THL, while combination of BETi and BCL2 inhibitor (ABT-199) had a significant (p < 0.005) inhibitory effect on survival followed by BCL-XL inhibition.

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PMC11739504

Scale bar: 20 μm.

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PMC11788920

Therefore, being able to regulate transcription by targeting the PQS with dCas9 promises to be a widely applicable and sequence specific method of transcription regulation, unlike alternative methods (such as small molecules or site-directed mutagenesis), which lack sequence specificity or transience.

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PMC8316344

F βTrCP increased the ubiquitination of TFRC.

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PMC11723947

Interestingly, we observed a significant enrichment of genes downregulated in HP1α-deficient cells among those that define Tex identity (Fig. 3n).

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PMC11763764

The identification of the key molecules in these pathways is a critical step towards developing targeted therapies to improve the clinical outcomes of patients with recurrent ovarian cancer.

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PMC9844987

We reasoned that a weaker association between low promoter variability and broad width than with high entropy may be due to low variable promoters being composed of multiple clusters of TSSs (multi-modal peaks) from independent core promoters.

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PMC11757131

Of these intermediate products, 3-HIB has attracted widespread attention in recent years (18, 19).

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PMC11437637

The data were compared using a two-paired t-test or a two-paired Mann-Whitney U test for normally distributed and non-normally distributed data, respectively.

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PMC10778532

RNA sequencing analysis revealed that VHL-C162F mutation upregulates genes involved in hypoxia and epithelial mesenchymal transition (EMT) pathways by comparison with VHL WT cells.

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PMC7504302

On the other hand, studies in human renal cell carcinomas suggest that the functional loss of SETD2 gene, together with other chromatin remodelers, could lead to epigenome aberrations and pathological splicing events, as discussed in further detail below.

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PMC10530622

Urinary oxalate excretion was higher in men, in higher body mass index, diabetes, creatinuria and proteinuria.

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PMC11411004

All conditions were performed in three independent replicates, and the data are expressed as the mean ± standard deviation (SD).

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PMC11628904

Therefore, we next probed for apoptotic death using antibodies against active‐caspase 3 in order to determine whether isotonic medium protects cells from this mode of death.

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PMC11803149

Photos of tumors isolated from mice analyzed on day 20.

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PMC11704834

It is noteworthy that it has been previously shown that Zeb1 is a critical TF in mediating TLE1-induced silencing of E-cadherin expression and TLE1-mediated EMT in LUAD cells (9).

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PMC11481779

To account for that, differences between the reference genome and an individual one (obtained by reads from an experiment) can be calculated.

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PMC9429973

Methods: CARDINAL is a two-part, open-label, single-arm study.

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