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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Positive conventional and positive NGS-based diagnostic were present in 18 events.
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PMC9429973
Although a higher incidence is observed with older age, longer series and comparative studies are needed to confirm these results.
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PMC9429973
Response was assessed every 8 weeks from cycle 3, and every 12 weeks from cycle 13 and was measured according to Lugano Classification.
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PMC9429973
More specifically, clonal hematopoiesis of indeterminate potential (CHIP) has been defined by hematopoietic clones with a variant allele frequency (VAF) ≥2% in the absence of hematologic disease.
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PMC9454852
The intracellular rise in ROS could be due to ER, but also due to mitochondrial release after the destabilization of mitochondrial membrane potential, as the ER and mitochondrial crosstalk plays a crucial role in the redox state and response .
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PMC11769516
Studies have shown that BA has excellent protective properties against T-2 toxin neurotoxicity.
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PMC11225860
Assays were performed in replicates of four and normalized to the DMSO treated condition.
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PMC11798926
These other AP complexes are involved in a variety of intracellular trafficking events for other AMPAR auxiliary proteins (Guardia et al., 2018).
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PMC11754094
In addition, compared with nCas9 (D10A), the cleavage activity of nCas9 (H840A) is not completely impaired and introduces DSBs with a low efficiency.
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PMC9739791
The picosecond transient absorption measurements conducted for PPE and prodrug 30 revealed that the transient state of prodrug 30 decays significantly faster than free polymer PPE (Table 12).
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PMC9429973
Aims: The aim of this study was to estimate prevalence of congenital and autoimmune neutropenia among Polish children and to improve the efficiency of recruiting patients with suspected SCN by launching the FIX-NET project with a nationwide advertising campaign.
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PMC11786767
According to the ranking score, the top miRNA (nucleotide residues 3,296–3,319, AAGAGCTTGCCTGATACAGAA) was chosen and cloned into pcDNA6.2-GW/EmGFP vector.
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PMC11257988
G12C is the most common mutation (45%) in former/current smokers, and G12D is the most common mutation (46%) in never-smokers .
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PMC7802142
The treatment of 30 μg/mL ReN-NV also produced significant higher cell proliferation than that of PBS at 72 h (P < 0.05) (Fig. 2c).
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PMC11566417
a Relative absorbance of MRSA when co-cultured with CM from primary and immortalized MDECs at various passages.
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PMC8753818
Findings of this research represented that the doubling time of CHO-KO had increased 6 h which was related to cell cycle arrest in G2/M phase.
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PMC11657744
Specifically, the cell cycle progressed after serum addition, resulting in an increased S phase at 12 h. These results suggest that the reduced AurA kinase levels in Cep89 or Fbf1 knockdown cells might be due to an altered phase of the cell cycle.
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PMC11803210
Upregulation of genes associated with epithelial-to-mesenchymal transition induced by Nar treatment in ER+ breast cancer cells offers a basis to explore and determine tumor-specific response to phytoestrogen treatment.
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PMC11622247
In initial experiments, microporation was conducted using “traditional” FIT probes, which contained only QB dyes.
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PMC11740207
If this hypothesis is valid, the leukemic equivalents in vitro would likely be VSLSLCs.
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PMC11449273
To explore p53 and plakoglobin interaction in another cellular system under the same genetic background condition, we took advantage of SKOV-3 ovarian carcinoma cells that are p53 null but express endogenous plakoglobin (Fig 2A).
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PMC9577200
The OD value of the control group without graphene (CK) was initially 0.01 and 0.02 for BC and PAO1, respectively.
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PMC3888431
Additionally, two different de novo assembly methods were used.
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PMC9429973
Summary/Conclusion: Achieving at least a minimal renal response as well as performing autoHSCT improve the PFS and OS in patients with newly diagnosed MM with dialysis-dependent RI.
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PMC11033180
The terminal part of the axonal arbor contains numerous branches emanating from the axon shaft.
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PMC10213199
In contrast, TCM prescriptions contain multiple active compounds.
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PMC6901583
This treatment abrogated the expression of CCL2 as well as the phosphorylation of p65 via BRD4 overexpression (Fig. 6d).
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PMC11513011
In T24 and KK47 cells, administration of DIB reduced the expression of FoxM1.
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PMC11092382
In addition, sophocarpine is closely associated with the p38MAPK signaling pathway in cardiovascular diseases.
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PMC9429973
This audit confirmed that a consultant-led approach means bone marrows meet approved indications every time.
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PMC11509224
In the in vitro biological activity experiment, compound 151 exhibited aromatase-inhibitory activity, with an IC50 value of 34.4 µM, and it also induced quinone reductase 1 (QR1) activity in cultured Hepa 1c1c7 cells, with a CD value (the concentration needed to double the QR1 activity) of 11.2 µM. Aromatase is an esse...
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PMC11400680
The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013).
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PMC11762280
C UVB skin damage of Ac-DEVD-CHO or PBS treated mice was evaluated by scores (n = 8).
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PMC11593031
This contrasts with older studies, such as the one by Do et al. in 2009 , which reported a more limited range of chromosomal alterations, likely due to the dynamic karyotype evolution of the Neuro-2a cell line over 15 years of culture.
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PMC4816271
T-cells from 5 donors were transduced with equal titers of retroviral supernatant coding for muK666 or huK666 CARs.
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PMC11321678
To identify the upstream regulators of the subgroup‐specific NTR genes, we proposed a trans‐regulatory network for NTR.
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PMC10809689
b.), (c.), and (d.) Represents glutamate (GLU) in retention time of 8.15 min, 7.89 min, and 8.14 min for control, PMA, and PG72 groups, respectively.
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PMC11476222
Calibration plots for GM3, GD1, GD2, and GD3 were generated, with R-squared values ranging from 0.9961 to 0.9975.
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PMC11337594
Ns: not significant, p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 TER induces GSDME-dependent cell pyroptosis via activated CASP3 in A375 cells. (
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PMC9429973
Maintenance also improved DFS (149 vs 82 months in non-maintenance group, p=0.0084); estimated 5 years DFS 77% vs 64%.
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PMC10887351
T-lymphocytes express both β2- and β3-ARs, among them β3-ARs were mainly upregulated in response to stress .
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PMC10654497
We combined the survival time, survival status, and data for the five characteristics using the R “RMS” software package and used the Cox method to create a nomogram to forecast the survival status of patients with LUAD at 1, 3, and 5 years (Fig. 9A).
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PMC9429973
We speculate that therapeutic cancer vaccination targeting immunosuppressive cells such as MDSC by vaccination using e.g. IDO, ARG or TGFβ derived epitopes will incite an anti-regulatory immune response, which may break the local immune suppression in the BM and allow effector immune cells to exert killing of transform...
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PMC11345828
This modification did not yield a consistent trend for either potency or clearance.
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PMC11012012
In human PBMCs from healthy donors, a limited SLAMF9/CD84-H1 reactivity in some circulating B cells was observed .
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PMC11775197
We need to explore the association between CRC and PPAR more.
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PMC11742431
PROTACs consist of three components, a ligand that binds to the protein of interest, a ligand that binds to the E3 ubiquitin ligase, and a linker between the two.
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PMC11748335
This accounts for the low DNA methylation observed in peaks within short LOCKs (Fig. 1B), which are notably enriched in CGI regions (Fig. 1D; Fig. 5B).
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PMC10212663
ITGA3, member of the integrin family, is an adhesion molecule expressed on the cell surface which can interact with extracellular matrix proteins.
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PMC11507371
Skin cancer is one of the most common malignancies worldwide.
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PMC10142392
Another way to access elegant architectures based on PCL is through the use of a combination of ROP and a six-armed dendrimer with alternating terminal groups free of hydroxyl and bromobutyrate, enabling the formation of multi-star arms.
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PMC11736898
Data are plotted as means ± standard deviations.
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PMC11502066
CXCR4 plays a critical role in the metastatic spread of different types of tumor cells mediating their homing to organs which express the specific ligand, C-X-C motif chemokine ligand 12 (CXCL12) .
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PMC11519788
The cells were harvested 48 h after transfection, and lysed to measure luciferase activity using a microplate reader (BioTek Instruments).
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PMC9817179
The knock-in A673 cell line was generated by genome editing of the A673 cell line that was comprehensively authenticated by ATCC before distribution (ATCC, CRL-1598).
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PMC11750165
COS cell line was grown in DMEM (Invitrogen, Carlsbad, CA, USA) supplemented with antibodies and 10% FBS.
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PMC9429973
Somatic SAMD9L mutations were noted in P1 and P2, both of which experienced a complete hematological and cytogenetic recovery.
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PMC10047551
DNA methylation was determined by pyrosequencing, and mRNA expression was determined by RT-qPCR.
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PMC10758402
Fluorescence was measured at 590 nm upon excitation at 530 nm.
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PMC11515150
12 C CAR-NK cells were superior to 5D CAR-NK cells in antitumor potential and 12 C.b CAR-T cells exhibited superior cytotoxic activity than 5D CAR-T cells ex vivo.
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PMC9429973
The median time from diagnosis to treatment was 3 weeks (1 week to 291 weeks).
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PMC11461874
Therefore, it is likely that the effect of TRAF7 overexpression on the cellular clock is mediated by down-regulation of DBP protein.
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PMC11297139
A673 cells were cultured with RPMI 1640 medium containing 10% fetal bovine serum (FBS) and antibiotics in a humidified incubator at 5% CO2 and 37 °C.
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PMC11633763
A key molecule in the Wnt/β‐catenin pathway is β‐catenin.
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PMC11752740
The plates were then placed in a CO2 incubator for a period ranging from 24- to 48-hours, depending on the specific experimental requirements.
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PMC11419566
These proteins were overexpressed in many types of cancer cells, indicating that ER stress exists in different cancer cells.
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PMC6222635
The Dendrobium officinale plants used in this study were divided into two groups, those planted in the greenhouse and those planted in the wild.
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PMC9398137
Annexin V-based cytotoxic assays, Western blot analysis, protein co-immunoprecipitation, and cell clones with manipulated expression of BCL2 family proteins were used to analyze mechanisms of sensitivity to S63845.
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PMC11543885
The Flp-In T-REx HEK293 cell line is thawed and cultured in complete medium containing 100 μg/mL Zeocin and 15 μg/mL Blasticidin selection antibiotic in a humidified 37°C, 5% CO2 incubator.b.
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PMC11477621
Meanwhile, the linker’s design can modulate molecular flexibility and accessibility to the zinc ion within the enzyme active site .
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PMC10454535
Following the study of the compounds’ effects individually, we sought to identify a synergistic combination of one RES derivative with BTZ and assess its effects on MM cell viability and apoptosis.
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PMC11612315
b Representative inward currents induced by 100 nM CAP in the presence of 100 nM exendin 9–39 (Exe 9–39; left).
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PMC9429973
The median time from the last dose of anti-PD1 was 69 days (range, 14-365).
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PMC11653533
Similarly, apigenin C8-glucoside and quercetin-3-O-β-rhamnoside isolated from ethanolic extract of the leaves of F. exasperata have manifested antimicrobial activity against S. aureus and B. subtilis with the zone of inhibition of 1.5 and 2.0 mm respectively against S. aureus and 1.2 and 2.5 respectively against B. sub...
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PMC9351137
After permeabilization in 0.2% Triton X-100 solution and washing in PBS, the cells were incubated in 3% bovine serum albumin (BSA) for 1 h and, subsequently, with primary antibodies overnight at 4 °C.
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PMC9587298
For 48 h exposure, an IC50 of 1.95 ± 0.03 mM was obtained.
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PMC10197932
On the other hand, leukemia and lymphoblast cells undergo deep changes in their viability, under US treatments 17,33 since they are more susceptible to ROS.
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PMC11345828
The aqueous layer was separated and extracted with EtOAc (2×).
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PMC9429973
The overall survival was 16 months in patients who received 1 or 2 cycles (15 patients) and not reached in patients who received 3 or 4 cycles (14 patients).
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PMC9429973
Treatment-related mortality was 7.6%.
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PMC9429973
Mean duration of FEDR Tx was 4.7 months.
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PMC11300639
Therefore, there is an urgent need to find new treatment strategies to address the resistance of ccRCC to antiangiogenic drugs.
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PMC7351993
The insets show enlarged images of the sorted and unsorted particles.
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PMC11534035
Therefore, the ethanol control was set to 100% proliferation for further statistical analysis and all treatment concentrations were considered relative to this group as the control.
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PMC11767725
We utilized a wide range of keywords and Medical Subject Headings (MeSH) terms to ensure a thorough search, including but not limited to skin microbiota, metabolic disorders, obesity, diabetes mellitus, dysbiosis, skin diseases, psoriasis, atopic dermatitis, microbial interactions, and ML.
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PMC9429973
We are currently validating the model on a second sickle cell cohort.
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PMC11352877
Another primary mode of angiogenic regulation is predominantly through angiopoietins 1 and 2, which compete to bind to the Tie2 receptor.
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PMC6222726
Traditionally, it is used to treat tumors and muscle spasms .
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PMC11684269
Non-alcoholic steatohepatitis (NASH) impairs the mitochondrial function and glucose uptake of CD8 T cells, diminishing its anti-tumor capacity.
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PMC10976516
These antigens are subsequently absorbed by antigen-presenting cells (APCs) such as dendritic cells, which then induce the formation of tumor- and virus-specific T cells.
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PMC11144200
P < 0.01, ****P < 0.0001.
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PMC11791264
The results from real-time PCR indicated that LC3B mRNA expression was not altered by either SETD7 OE in SKOV3 cells (Fig. S2A) or SETD7 KD in A2780 cells (Fig. S2B).
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PMC9429973
In patients with SCD, the GBT021601 100 mg maintenance dose led to a mean Hb occupancy >30%, increased Hb, reduced markers of hemolysis, and improved RBC health.
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PMC9429973
We found a wide range of variability and no substantial difference between the GCB and non-GCB subtypes regarding the extent of SHP1 expression.
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PMC11285179
PAN-CK, NG2, CD31, and CCL28 were stained in tumor tissues to analyze their expression levels with the therapeutic efficacy of bevacizumab treatment.
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PMC11045125
Lymphomas infected with ΔEBNA2 EBV alone resemble diffuse large B cell lymphomas with large polymorphous B cells, including some multinucleated cells, while tumors infected with both ΔEBNA2 EBV and Myc are composed of homogenous, medium-sized B cells with distinct cytoplasmic borders and numerous mitotic figures, close...
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PMC9918897
It can be assumed that, at the levels used in our study, XN can only partially counteract the adverse factors of the alcoholic medium.
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PMC10335954
After sorting and analyzing The Cancer Genome Atlas (TCGA) database in our first-phase research, thyroid hormone receptor interactor 13 (TRIP13) was singled out as a candidate for the targeted treatment of gastric malignancy.
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PMC9822769
To maintain resistance in A2780cisR cells, cisplatin (1 μM) was added to the medium every two passages.
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PMC11461874
The bioluminescence signals were continuously recorded for 5–10 days at 37 °C in air with Dish Type Luminescencer, LumiCycle (Actimetrics) and Kronos (ATTO, AB-2500).
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