OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10079526	D Panel displays representative images of 2 mice per group for days shown in B. E Survival plot depicts survival of mice per group over the time course of the experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11673902	For example, some methods may accurately measure the mechanical response of cells by applying microfluidics to apply precise pressure or shear stresses, while others may utilize microstructural arrays to enable high-throughput determination of cellular mechanical properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Forty-one patients with a median age of 51 (range 31–78) years were enrolled in the study over the time period 1994-2020.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8409415	P < .01; Kruskal‐Wallis H test was used to compare groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", ".01", ";", "Kruskal‐Wallis", "H", "test", "was", "used", "to", ...
PMC11519567	Data are mean±s.d.,	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "mean±s.d", ".", "," ] } ]
PMC11422150	Quantitative PCR at the SCI site, where the hAMSC treatment suppressed TNF-α expression and enhanced BDNF expression (D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantitative", "PCR", ...
PMC5833712	Proteins were separated by SDS-PAGE under reducing conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteins", "were", "separated", "by", "SDS-PAGE", "under", "reducing", "conditions", "." ] } ]
PMC11471157	MS-1 cell line was obtained from ATCC (Manassas, VA, USA).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MS-1", "cell", "line", "was", "obtained", "from", "ATCC", ...
PMC9429973	Aims: To understand and predict the 3D genome consequence of IGH-CCND1 translocation events using the highly predictive heteromorphic polymer model (HiP-HoP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11216402	Clustering in the inferred motif activity space generates a PCA plot with the same grouping detected in the ATAC-seq signal (Fig. 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8348645	Test for Carbohydrates: Molisch’s test: We mixed 0.2 mL of sample with a few drops of Molisch’s reagent (α-naphthol dissolved in alcohol).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655536	As shown in Fig. 1H, the cell viability was significantly reduced by HA in all tested primary bone marrow cells from ten patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11725127	The mutation of Cys284 does eliminate the covalent binding of GA to USP2, but it doesn't affect the binding of GA to the allosteric pocket.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6468656	Among those MMPs identified, MMP10 was associated with poor survival in ccRCC, and the upregulation of MMP10 was induced by the ghrelin-ghrelin receptor-Aurora A signaling axis to promote ccRCC metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461874	Bioluminescence from firefly luciferase was normalized by that of renilla luciferase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bioluminescence", "from", "firefly", "luciferase", "was", "normalized", "by", "that", "of",...
PMC7570809	Finally, to investigate if cell death induced by the RGDechi15D effect is due to the apoptosis process, a caspase-3 activity assay was carried out.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11543935	In combination with devices that can be used in MR environments, like the STIMULATE device, the Bio-Phantom can be used for the training of image-guided interventions, followed by treatment analysis using multiple assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11317131	Additional rounds of evolution did not result in variants with increased efficiency (Supplementary Figure S4 and Supplementary Note S5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "rounds", ...
PMC8632470	Then, the cells were 24-hour toxicity-induced with 30 μM of cadmium chloride.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "the", "cells", "were", "24-hour", "toxicity-induced", "with", ...
PMC11737091	Concurrently, the expression levels of Cyclin D1 were significantly reduced, leading to the blockade of DNA replication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Concurrently", ",", "the", "expre...
PMC6160470	First we employed UIC2 shift assay to inspect whether crown ethers affect P-gp conformation, and to establish the nature of the interaction or modulation we complemented it with an ATPase assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11626627	Fig 1 TWIST1 is a downstream target gene of miR-204–3p. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig", "1", "TWIST1", "is", "a", "downstream", "target", "gene", "of", "miR-204–3p", ...
PMC11462673	Incubate the cells in a humidified incubator at 37 °C with 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Incubate", "the", "cells", "in", "a", "humidified", "incuba...
PMC9429973	Image: Summary/Conclusion: Within AML, SF3B1 mutations are enriched in AML patients with GATA2::MECOM and AML-MRC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", ...
PMC6642070	The beads were washed by ice-cold cell lysis buffer and 1× SDS-PAGE sample loading buffer was added.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "beads", "were", "washed", "by",...
PMC11345828	The reaction was poured into brine and extracted with EtOAc.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reaction", "was", "poured", "into", "brine", "and", "extracted", "with", "EtOAc", "...
PMC9429973	Clinical and radiological features are diverse; the diagnosis is confirmed by cerebrospinal fluid (CSF) analysis using immunological and molecular techniques.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinica...
PMC11730320	At the DN3 stage, cells expressing TCRβ chain genes continue to develop as αβ lineage cells and later express pTCRα which is needed for development of a diverse TCR repertoire and progression to CD4+CD8+ double positive (DP) thymocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401358	All morphological characterization was performed by tapping mode in air at a scan rate of 2.0 Hz and a resolution of 256 × 256 pixels per image using AC160TS-R3 probes (Olympus, Tpkyo, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11488203	Following transfection with the indicated miRs, different GFP-labeled human cancer cell lines including A549 lung carcinoma, MDA-MB-231 breast carcinoma, and SK-OV-3 ovarian cancer cells were incubated for 72 h while slow-growing HT-29 colon adenocarcinoma and CCF-STTG1 astrocytoma cells were cultured for 168 h. Therea...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O"...
PMC11774112	We successfully developed the Co-PHRD polypeptide micelle system for the co-delivery of miRNA-34a and DTIC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "successfully", "developed", "the", "Co-PHRD", "polypeptide"...
PMC3734024	B cells capable of secreting IL-10 are reportedly enriched in several B cell subsets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "cells", "capable", "of", "secreting", "IL-10", "are", "repo...
PMC11676169	For experiments mapping the regions of interaction between XRCC5 or XRCC6 and BCAT1, HEK 293T cells were co-transfected with expression vectors for full-length XRCC6 (pcDNA-HAXRCC6 (1–609)) or full-length XRCC5 (pLenti-HAXRCC6 (1–732)) and BCAT1 deletion mutants in the pLenti-Myc-DDK-P2A-Puro vector (N-terminal (1–197)...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Of the 34 laboratories evaluated, five analysed TP53 only, with four of these utilising a non-disease specific myeloid NGS panel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "the", ...
PMC11536589	Data represent means ± SEM from three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represent", "means", "±", "SEM", "from", "three", "independent", "experiments", "." ] } ]
PMC6182045	Following growth and selection, the 10 best growing clones were grown in six-day batch culture and assayed for gp120 expression by quantitative ELISA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7917457	The VALO-mD901 virus, a murine surrogate version of VALO-D102, was generated similarly to VALO-D102.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "VALO-mD901", "virus", ",", "a", "murine", ...
PMC9261184	The calibration results must be within ±5% of the actual value to validate results as per US EPA Method 320.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "calibration", ...
PMC11607321	This asymmetrical design was chosen for its ability to maintain the model’s predictive and reconstructive capacities while streamlining its architecture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "asymmetrical", ...
PMC11089031	The IHC results showed similar patterns of ZNF692 expression in kidney-resident immune cells and kidney tissue cells identified by mRNA expression analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IHC",...
PMC5574817	Amplification of this plasmid DNA was carried out by transformation into the DH5α strain of Escherichia coli bacteria (Invitrogen, USA) using standard laboratory protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754291	Representative images from donor K3 on day 7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "from", "donor", "K3", "on", "day", "7", "." ] } ]
PMC5925824	High resolution crystallographic data sets have demonstrated that the epitopes of the PD-1 blocking antibodies nivolumab and pembrolizumab structurally cluster on the flat PD-L1-binding surface of PD-1 and overlap with the binding site for PD-L1 [17–19].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7553912	The full-length blots are presented in Supplementary Fig. S4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "full-length", "blots", "are", "presented", "in", "Supplementary", "Fig.", "S4", "." ] } ]
PMC11402217	Additionally, XD23’s ability to significantly reduce colony formation in OS cells further confirms its suppressive role in cell proliferation (Figures 1C–1E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10988555	Moreover, melting curve analysis of CT-DNA in the presence of complexes led to total quenching of Evagreen dye fluorescence which further validated their interaction with DNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	At 72 hpi, viral replication was quantified using fluorescence microscopy (RRV-GFP and ONNV-GFP) or luciferase assays (VSV-LUC and SINV-LUC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11547917	Our study aimed to investigate in more detail the in vitro antioxidant properties and in vitro cytotoxic activity of the Aristolochia clematitis extract.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", ...
PMC2614415	To confirm the effects were due to Aurora-A specific inhibition, we treated 1A9 cells with both low and high doses of VE-465 for 96 hours and probed immunoblots for phospho-Aurora-B (T232) and phospho-p53 (S315) (Fig. 4G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11507371	This notion finds support in the slightly elevated basal Nrf2 localisation in A431 nuclei, indicating heightened Nrf2 activity associated with basal redox adaptation (Figure 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11531744	Therefore, there was an urgently need to find effective systemic therapy and identify novel biomarkers of prognosis assessment for OC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", ...
PMC10747139	The development of novel drugs that can have double biological behavior (anticancer–antiviral, anticancer–antimicrobial, etc.),	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11486946	Single-molecule imaging and the phosphorylation assay began 1 and 2 min after the EGF addition, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single-molecule", "imaging", "and", "the", "phosp...
PMC9065483	The 786-0 (human male renal cell adenocarcinoma, cat.	[ { "tags": [ "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "786", "-", "0", "(", "human", "male", "renal", ...
PMC7351993	However, it is not meaningful to have more than several colors in this high-frequency spectral region since only several independent components can be resolved in the region even if the full spectral information is obtained.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	There were 12 grade 5 AEs (11 and 1 patients in the R/R and TN cohorts, respectively); 1 (intracranial hematoma [R/R]) was considered treatment-related.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6948907	So we can get the optical density (OD) of every well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "So", "we", "can", "get", "the", "optical", "density", "(", "OD", ...
PMC11539788	The expression levels of the target genes were determined using the comparative Ct method (ΔΔCT) and normalized to the expression level of the GAPDH gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11185260	p<0.05. (	[ { "tags": [ "O", "O", "O" ], "tokens": [ "p<0.05", ".", "(" ] } ]
PMC9341513	DHSs often coincide with regulatory elements such as promoters and enhancers; particularly in U266 there is a cluster of DHSs near and within CCND1 which is not present in GM12878.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10024132	However, because NK cells lack of surface CD3 molecules, the cell type would not be applicable for combining with blinatumomab in cancer treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10317042	The Hewga-CCS cell line was used for high-throughput screening.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Hewga-CCS", "cell", "line", "was", "used", "for", "high-throughput", "screening", "." ]...
PMC11806182	In contrast, the three down-regulated genes—WBP1L, WFS1, and AXIN2—were associated with longer overall survival and were involved in the positive regulation of protein ubiquitination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5963610	Multiple clinical trials have been performed with the NGcGM3-containing vaccine, developed at the Center of Molecular Immunology (CIM) for melanoma and breast cancer showing evidences of clinical effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755467	Typically, each 50 μM final standard concentration of compound in 500 μL cell culture media volume had a final concentration of 25 μM of NaOH and 0.25% DMSO, which were well tolerated by cells as tested for viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739696	These findings highlight the novel potential of Co3O4NPs as potent inducers of melanoma A-375 cell death in a concentration-dependent manner through excessive ROS production, genomic instability, mitochondrial dysfunction and dysregulation of apoptotic and mitochondrial gene expression, ultimately promoting apoptosis i...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11013014	Chemical shifts (δ) are expressed in parts per million (ppm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chemical", "shifts", "(", "δ", ")", "are", "expressed", "in", ...
PMC11706776	p < 0.05; p < 0.01; p < 0.001 and ***p < 0.0001. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10604092	However, interestingly, we observed that the adipose tissue weights did not decrease in the SLC-transplanted rats fed an isocaloric diet (Figure 6D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Image: Summary/Conclusion: The IST has a lower response rate in our center compared to what has been published internationally.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Sum...
PMC11300639	We standardized the results using the Z score method, where darker red represents stronger binding to TSC1 and larger positive values, and conversely, darker blue represents weaker binding to TSC1 and smaller negative values.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9143157	Because THP was conjugated to the HPMA polymer by the hydrazone bond, the release of free THP from P-THP occurred constantly and slowly in physiological pH, but rapid release was triggered at an acidic pH , so a long time incubation results in an increased amount of released free THP, and the decreased pH in the medium...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11066331	Peak lists for all mass spectra were converted to the feature matrix.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Peak", "lists", "for", "all", "mass", "spectra", "were", "converted", "to", ...
PMC10976516	Song et al.Ad.hTERT-E1A-TK, recombinant Ad5 expressing HSV-TK and hTERT drivingIntratumoralAd.hTERT-E1A-TK infection combined with administration of prodrug gancyclovir (GCV) resulted in more potent cytotoxicity on A549 cells and synergistically suppressed human lung cancer A549 tumor growth in the subcutaneous xenotra...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740573	The susceptibility results were interpreted in accordance with established breakpoint criteria (EUCAST – European Committee on Anti-microbial Susceptibility Testing for amoxicillin/clavulanic acid and moxifloxacin, and CLSI – The Clinical and Laboratory Standards Institute for kanamycin).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11795610	Subsequently, the cells were incubated at 4℃ overnight with the following antibodies: anti-filaggrin antibody (1:200), anti-involucrin (1:200), and anti-TRPV4 (1:200).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	V. Navrkalova, J. Kotaskova, K. Plevova, T. Reigl, M. Valisova, M. Bohunova, M. Zenatova, L. Radova, A. Panovska, S. Pospisilova Internal Medicine - Hematology and Oncology, University Hospital Brno and Masaryk University; Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czechia B...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012012	SLAMF4/CD244 was not expressed by B cells and it was found to be negative in CLL and BL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SLAMF4/CD244", "was", "not", "expressed", ...
PMC11011020	The chronoamperometric analysis shows that the current density changes derived from the cell lines are easily detectable against that of the control. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9784246	The MeOH fraction exerted the most potent cytotoxic activity (IC50 = 1.57 ± 0.04 μg/mL), while the total extract exhibited 50% growth inhibition at an almost two-fold concentration (3.3 ± 0.19 μg/mL) as that of the MeOH fraction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11532793	This article has focused on pipelines using transcript quantification from Salmon or kallisto, because of their speed and popularity, but the edgeR DTE analysis pipeline examined here can also be used with RSEM output (8) via edgeR’s catchRSEM function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9046263	In concordance with our findings of overexpressed HML-6 expression in GBM cell lines, the two patient-derived neurosphere lines were both derived from patients harboring the classical GBM subtype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012313	Recent genomic studies that analyzed the phosphorylation of tyrosine residues between LCLs that were stimulated through the BCR or only through LMP2A demonstrated similarities in upstream activated proteins (such as Lyn, SYK, BTK) but only 12% in similarities further downstream .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787651	We next integrated these converted data with our EpiProfile (version 2.1), as the generated “ms1” and “ms2” files can be examined to resolve the comprehensive histone PTM information, including the isobaric histone peptides, low-abundant PTMs, different histone mutations, different derivatization strategies, and histon...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9250505	Forced expression of hBADS99-flag did not appreciably decrease hBADS99 compared to vector-transfected cells but pBADS99 was significantly less than that observed in hBAD-flag transfected cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11585587	The differences between multiple groups were evaluated using one-way ANOVA and the Dunnett t-test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "differences", "between", "multiple", "groups", "were", "evaluat...
PMC11723210	The reconstruction process is summarized in Figure 2, comprising four main stages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reconstruction", "process", "is", "summarized", "in", "Figure", "2",...
PMC11708541	The effects of 3,4-DAP 84 and other AP on respiratory and ventilation during the later stages of botulism in mice were examined using unrestrained whole-body plethysmography (UWBP) and arterial blood gas measurements in combination (Fig. 16).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Our study has several limitations that should be considered when reviewing the results, including the retrospective design and inclusion of a small number of patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11626627	Subsequently, the anti-TWIST1 antibody (Proteintech, Cat No: 25,465–1-AP) or IgG was added to the cell lysate and incubated overnight at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11467800	Extravasation observation assays were done with the same larvae for 3 days repeatedly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Extravasation", "observation", "assays", "were", "done", "with", "the", "sa...
PMC11012313	While this paper did not identify the signals from LMP2A that are required to reach this effect, subsequent studies using this same mouse model of Burkitt’s lymphoma demonstrated that the mTOR inhibitor, rapamycin, blocks the LMP2A-mediated enhancement in tumor development .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10538569	After overnight incubation at 37°C, 500 µl supernatant was removed and 750 µl fresh complete RPMI 1640 medium supplemented with human rIL-2 (100 IU/ml) were added into cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11495567	The treated cells were then fixed and stained with Alexa Fluor568 phalloidin stain mixed with Hoechst stain as described in the methods.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "treat...
PMC7039683	All GFP-positive active enhancers (GPAEs) were resized into 400 bp regions that maximize the overall ATAC-seq signal within each NFR; all GPAEs composed of > 70% repeats were removed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	For each patient, with NIH ImageJ software, we extracted the areas of subcutaneous fat, visceral fat and the skeletal muscle from an unenhanced axial CT image at vertebra L3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	ERK is phosphorylated via EGFR activation, and reduced ERK phosphorylation attenuates in the transcription of genes involved in the cholesterol biosynthesis pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ERK", ...
PMC11794847	Glucose utilization, lactic acid detection, and intracellular ATP detection assays revealed that the activated T cells have a significantly enhanced glucose utilization, lactic acid production, and intracellular ATP levels, indicating a higher glycolysis level (Fig. 5D–F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11609529	Parental Heya-8 cells were included as a control. (	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Parental", "Heya-8", "cells", "were", "included", "as", "a", "control", ".", "(" ] } ]
PMC8041314	Finally, the manual selection posed also a risk of faulty selection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "manual", "selection", "posed", "also", "a", "risk", ...

PMC10079526

D Panel displays representative images of 2 mice per group for days shown in B. E Survival plot depicts survival of mice per group over the time course of the experiment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11673902

For example, some methods may accurately measure the mechanical response of cells by applying microfluidics to apply precise pressure or shear stresses, while others may utilize microstructural arrays to enable high-throughput determination of cellular mechanical properties.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Results: Forty-one patients with a median age of 51 (range 31–78) years were enrolled in the study over the time period 1994-2020.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8409415

P < .01; Kruskal‐Wallis H test was used to compare groups.

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PMC11519567

Data are mean±s.d.,

[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "mean±s.d", ".", "," ] } ]

PMC11422150

Quantitative PCR at the SCI site, where the hAMSC treatment suppressed TNF-α expression and enhanced BDNF expression (D).

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PMC5833712

Proteins were separated by SDS-PAGE under reducing conditions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteins", "were", "separated", "by", "SDS-PAGE", "under", "reducing", "conditions", "." ] } ]

PMC11471157

MS-1 cell line was obtained from ATCC (Manassas, VA, USA).

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PMC9429973

Aims: To understand and predict the 3D genome consequence of IGH-CCND1 translocation events using the highly predictive heteromorphic polymer model (HiP-HoP).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11216402

Clustering in the inferred motif activity space generates a PCA plot with the same grouping detected in the ATAC-seq signal (Fig. 1A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC8348645

Test for Carbohydrates: Molisch’s test: We mixed 0.2 mL of sample with a few drops of Molisch’s reagent (α-naphthol dissolved in alcohol).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11655536

As shown in Fig. 1H, the cell viability was significantly reduced by HA in all tested primary bone marrow cells from ten patients.

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PMC11725127

The mutation of Cys284 does eliminate the covalent binding of GA to USP2, but it doesn't affect the binding of GA to the allosteric pocket.

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PMC6468656

Among those MMPs identified, MMP10 was associated with poor survival in ccRCC, and the upregulation of MMP10 was induced by the ghrelin-ghrelin receptor-Aurora A signaling axis to promote ccRCC metastasis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11461874

Bioluminescence from firefly luciferase was normalized by that of renilla luciferase.

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PMC7570809

Finally, to investigate if cell death induced by the RGDechi15D effect is due to the apoptosis process, a caspase-3 activity assay was carried out.

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PMC11543935

In combination with devices that can be used in MR environments, like the STIMULATE device, the Bio-Phantom can be used for the training of image-guided interventions, followed by treatment analysis using multiple assays.

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PMC11317131

Additional rounds of evolution did not result in variants with increased efficiency (Supplementary Figure S4 and Supplementary Note S5).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "rounds", ...

PMC8632470

Then, the cells were 24-hour toxicity-induced with 30 μM of cadmium chloride.

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PMC11737091

Concurrently, the expression levels of Cyclin D1 were significantly reduced, leading to the blockade of DNA replication.

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PMC6160470

First we employed UIC2 shift assay to inspect whether crown ethers affect P-gp conformation, and to establish the nature of the interaction or modulation we complemented it with an ATPase assay.

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PMC11626627

Fig 1 TWIST1 is a downstream target gene of miR-204–3p. (

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PMC11462673

Incubate the cells in a humidified incubator at 37 °C with 5% CO2.

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PMC9429973

Image: Summary/Conclusion: Within AML, SF3B1 mutations are enriched in AML patients with GATA2::MECOM and AML-MRC.

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PMC6642070

The beads were washed by ice-cold cell lysis buffer and 1× SDS-PAGE sample loading buffer was added.

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PMC11345828

The reaction was poured into brine and extracted with EtOAc.

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PMC9429973

Clinical and radiological features are diverse; the diagnosis is confirmed by cerebrospinal fluid (CSF) analysis using immunological and molecular techniques.

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PMC11730320

At the DN3 stage, cells expressing TCRβ chain genes continue to develop as αβ lineage cells and later express pTCRα which is needed for development of a diverse TCR repertoire and progression to CD4+CD8+ double positive (DP) thymocytes.

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PMC11401358

All morphological characterization was performed by tapping mode in air at a scan rate of 2.0 Hz and a resolution of 256 × 256 pixels per image using AC160TS-R3 probes (Olympus, Tpkyo, Japan).

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PMC11488203

Following transfection with the indicated miRs, different GFP-labeled human cancer cell lines including A549 lung carcinoma, MDA-MB-231 breast carcinoma, and SK-OV-3 ovarian cancer cells were incubated for 72 h while slow-growing HT-29 colon adenocarcinoma and CCF-STTG1 astrocytoma cells were cultured for 168 h. Therea...

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PMC11774112

We successfully developed the Co-PHRD polypeptide micelle system for the co-delivery of miRNA-34a and DTIC.

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PMC3734024

B cells capable of secreting IL-10 are reportedly enriched in several B cell subsets.

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PMC11676169

For experiments mapping the regions of interaction between XRCC5 or XRCC6 and BCAT1, HEK 293T cells were co-transfected with expression vectors for full-length XRCC6 (pcDNA-HAXRCC6 (1–609)) or full-length XRCC5 (pLenti-HAXRCC6 (1–732)) and BCAT1 deletion mutants in the pLenti-Myc-DDK-P2A-Puro vector (N-terminal (1–197)...

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PMC9429973

Of the 34 laboratories evaluated, five analysed TP53 only, with four of these utilising a non-disease specific myeloid NGS panel.

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PMC11536589

Data represent means ± SEM from three independent experiments.

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PMC6182045

Following growth and selection, the 10 best growing clones were grown in six-day batch culture and assayed for gp120 expression by quantitative ELISA.

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PMC7917457

The VALO-mD901 virus, a murine surrogate version of VALO-D102, was generated similarly to VALO-D102.

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PMC9261184

The calibration results must be within ±5% of the actual value to validate results as per US EPA Method 320.

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PMC11607321

This asymmetrical design was chosen for its ability to maintain the model’s predictive and reconstructive capacities while streamlining its architecture.

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PMC11089031

The IHC results showed similar patterns of ZNF692 expression in kidney-resident immune cells and kidney tissue cells identified by mRNA expression analysis.

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PMC5574817

Amplification of this plasmid DNA was carried out by transformation into the DH5α strain of Escherichia coli bacteria (Invitrogen, USA) using standard laboratory protocol.

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PMC11754291

Representative images from donor K3 on day 7.

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PMC5925824

High resolution crystallographic data sets have demonstrated that the epitopes of the PD-1 blocking antibodies nivolumab and pembrolizumab structurally cluster on the flat PD-L1-binding surface of PD-1 and overlap with the binding site for PD-L1 [17–19].

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PMC7553912

The full-length blots are presented in Supplementary Fig. S4.

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PMC11402217

Additionally, XD23’s ability to significantly reduce colony formation in OS cells further confirms its suppressive role in cell proliferation (Figures 1C–1E).

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PMC10988555

Moreover, melting curve analysis of CT-DNA in the presence of complexes led to total quenching of Evagreen dye fluorescence which further validated their interaction with DNA.

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PMC11098378

At 72 hpi, viral replication was quantified using fluorescence microscopy (RRV-GFP and ONNV-GFP) or luciferase assays (VSV-LUC and SINV-LUC).

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PMC11547917

Our study aimed to investigate in more detail the in vitro antioxidant properties and in vitro cytotoxic activity of the Aristolochia clematitis extract.

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PMC2614415

To confirm the effects were due to Aurora-A specific inhibition, we treated 1A9 cells with both low and high doses of VE-465 for 96 hours and probed immunoblots for phospho-Aurora-B (T232) and phospho-p53 (S315) (Fig. 4G).

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PMC11507371

This notion finds support in the slightly elevated basal Nrf2 localisation in A431 nuclei, indicating heightened Nrf2 activity associated with basal redox adaptation (Figure 2C).

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PMC11531744

Therefore, there was an urgently need to find effective systemic therapy and identify novel biomarkers of prognosis assessment for OC.

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PMC10747139

The development of novel drugs that can have double biological behavior (anticancer–antiviral, anticancer–antimicrobial, etc.),

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PMC11486946

Single-molecule imaging and the phosphorylation assay began 1 and 2 min after the EGF addition, respectively.

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PMC9065483

The 786-0 (human male renal cell adenocarcinoma, cat.

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PMC7351993

However, it is not meaningful to have more than several colors in this high-frequency spectral region since only several independent components can be resolved in the region even if the full spectral information is obtained.

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PMC9429973

There were 12 grade 5 AEs (11 and 1 patients in the R/R and TN cohorts, respectively); 1 (intracranial hematoma [R/R]) was considered treatment-related.

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PMC6948907

So we can get the optical density (OD) of every well.

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PMC11539788

The expression levels of the target genes were determined using the comparative Ct method (ΔΔCT) and normalized to the expression level of the GAPDH gene.

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PMC11185260

p<0.05. (

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PMC9341513

DHSs often coincide with regulatory elements such as promoters and enhancers; particularly in U266 there is a cluster of DHSs near and within CCND1 which is not present in GM12878.

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PMC10024132

However, because NK cells lack of surface CD3 molecules, the cell type would not be applicable for combining with blinatumomab in cancer treatment.

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PMC10317042

The Hewga-CCS cell line was used for high-throughput screening.

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PMC11806182

In contrast, the three down-regulated genes—WBP1L, WFS1, and AXIN2—were associated with longer overall survival and were involved in the positive regulation of protein ubiquitination.

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PMC5963610

Multiple clinical trials have been performed with the NGcGM3-containing vaccine, developed at the Center of Molecular Immunology (CIM) for melanoma and breast cancer showing evidences of clinical effect.

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PMC11755467

Typically, each 50 μM final standard concentration of compound in 500 μL cell culture media volume had a final concentration of 25 μM of NaOH and 0.25% DMSO, which were well tolerated by cells as tested for viability.

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PMC11739696

These findings highlight the novel potential of Co3O4NPs as potent inducers of melanoma A-375 cell death in a concentration-dependent manner through excessive ROS production, genomic instability, mitochondrial dysfunction and dysregulation of apoptotic and mitochondrial gene expression, ultimately promoting apoptosis i...

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PMC11013014

Chemical shifts (δ) are expressed in parts per million (ppm).

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PMC11706776

p < 0.05; **p < 0.01; ***p < 0.001 and ****p < 0.0001. (

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PMC10604092

However, interestingly, we observed that the adipose tissue weights did not decrease in the SLC-transplanted rats fed an isocaloric diet (Figure 6D).

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PMC9429973

Image: Summary/Conclusion: The IST has a lower response rate in our center compared to what has been published internationally.

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PMC11300639

We standardized the results using the Z score method, where darker red represents stronger binding to TSC1 and larger positive values, and conversely, darker blue represents weaker binding to TSC1 and smaller negative values.

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PMC9143157

Because THP was conjugated to the HPMA polymer by the hydrazone bond, the release of free THP from P-THP occurred constantly and slowly in physiological pH, but rapid release was triggered at an acidic pH , so a long time incubation results in an increased amount of released free THP, and the decreased pH in the medium...

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PMC11066331

Peak lists for all mass spectra were converted to the feature matrix.

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PMC10976516

Song et al.Ad.hTERT-E1A-TK, recombinant Ad5 expressing HSV-TK and hTERT drivingIntratumoralAd.hTERT-E1A-TK infection combined with administration of prodrug gancyclovir (GCV) resulted in more potent cytotoxicity on A549 cells and synergistically suppressed human lung cancer A549 tumor growth in the subcutaneous xenotra...

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PMC11740573

The susceptibility results were interpreted in accordance with established breakpoint criteria (EUCAST – European Committee on Anti-microbial Susceptibility Testing for amoxicillin/clavulanic acid and moxifloxacin, and CLSI – The Clinical and Laboratory Standards Institute for kanamycin).

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PMC11795610

Subsequently, the cells were incubated at 4℃ overnight with the following antibodies: anti-filaggrin antibody (1:200), anti-involucrin (1:200), and anti-TRPV4 (1:200).

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PMC9429973

V. Navrkalova, J. Kotaskova, K. Plevova, T. Reigl, M. Valisova, M. Bohunova, M. Zenatova, L. Radova, A. Panovska, S. Pospisilova Internal Medicine - Hematology and Oncology, University Hospital Brno and Masaryk University; Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czechia B...

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PMC11012012

SLAMF4/CD244 was not expressed by B cells and it was found to be negative in CLL and BL.

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PMC11011020

The chronoamperometric analysis shows that the current density changes derived from the cell lines are easily detectable against that of the control. (

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PMC9784246

The MeOH fraction exerted the most potent cytotoxic activity (IC50 = 1.57 ± 0.04 μg/mL), while the total extract exhibited 50% growth inhibition at an almost two-fold concentration (3.3 ± 0.19 μg/mL) as that of the MeOH fraction.

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PMC11532793

This article has focused on pipelines using transcript quantification from Salmon or kallisto, because of their speed and popularity, but the edgeR DTE analysis pipeline examined here can also be used with RSEM output (8) via edgeR’s catchRSEM function.

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PMC9046263

In concordance with our findings of overexpressed HML-6 expression in GBM cell lines, the two patient-derived neurosphere lines were both derived from patients harboring the classical GBM subtype.

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PMC11012313

Recent genomic studies that analyzed the phosphorylation of tyrosine residues between LCLs that were stimulated through the BCR or only through LMP2A demonstrated similarities in upstream activated proteins (such as Lyn, SYK, BTK) but only 12% in similarities further downstream .

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PMC11787651

We next integrated these converted data with our EpiProfile (version 2.1), as the generated “ms1” and “ms2” files can be examined to resolve the comprehensive histone PTM information, including the isobaric histone peptides, low-abundant PTMs, different histone mutations, different derivatization strategies, and histon...

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PMC9250505

Forced expression of hBADS99-flag did not appreciably decrease hBADS99 compared to vector-transfected cells but pBADS99 was significantly less than that observed in hBAD-flag transfected cells.

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PMC11585587

The differences between multiple groups were evaluated using one-way ANOVA and the Dunnett t-test.

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PMC11723210

The reconstruction process is summarized in Figure 2, comprising four main stages.

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PMC11708541

The effects of 3,4-DAP 84 and other AP on respiratory and ventilation during the later stages of botulism in mice were examined using unrestrained whole-body plethysmography (UWBP) and arterial blood gas measurements in combination (Fig. 16).

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PMC9429973

Our study has several limitations that should be considered when reviewing the results, including the retrospective design and inclusion of a small number of patients.

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PMC11626627

Subsequently, the anti-TWIST1 antibody (Proteintech, Cat No: 25,465–1-AP) or IgG was added to the cell lysate and incubated overnight at 4 °C.

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PMC11467800

Extravasation observation assays were done with the same larvae for 3 days repeatedly.

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PMC11012313

While this paper did not identify the signals from LMP2A that are required to reach this effect, subsequent studies using this same mouse model of Burkitt’s lymphoma demonstrated that the mTOR inhibitor, rapamycin, blocks the LMP2A-mediated enhancement in tumor development .

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PMC10538569

After overnight incubation at 37°C, 500 µl supernatant was removed and 750 µl fresh complete RPMI 1640 medium supplemented with human rIL-2 (100 IU/ml) were added into cells.

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PMC11495567

The treated cells were then fixed and stained with Alexa Fluor568 phalloidin stain mixed with Hoechst stain as described in the methods.

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PMC7039683

All GFP-positive active enhancers (GPAEs) were resized into 400 bp regions that maximize the overall ATAC-seq signal within each NFR; all GPAEs composed of > 70% repeats were removed.

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PMC9429973

For each patient, with NIH ImageJ software, we extracted the areas of subcutaneous fat, visceral fat and the skeletal muscle from an unenhanced axial CT image at vertebra L3.

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PMC11754432

ERK is phosphorylated via EGFR activation, and reduced ERK phosphorylation attenuates in the transcription of genes involved in the cholesterol biosynthesis pathway.

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PMC11794847

Glucose utilization, lactic acid detection, and intracellular ATP detection assays revealed that the activated T cells have a significantly enhanced glucose utilization, lactic acid production, and intracellular ATP levels, indicating a higher glycolysis level (Fig. 5D–F).

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PMC11609529

Parental Heya-8 cells were included as a control. (

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PMC8041314

Finally, the manual selection posed also a risk of faulty selection.

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