OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	All of them occurred during the first time of infusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "of", "them", "occurred", "during", "the", "first", "time", "of", "infusion", "." ...
PMC11611077	CHO cells transfected with prestin and untransfected CHO cells were fixed with 4% paraformaldehyde in phosphate buffer at room temperature for 5 min and washed with PBS.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	E. Monzón Manzano, M. T. Alvarez Román, P. Acuña, E. G. Arias Salgado, A. Ramírez, M. Martín Salces, M. I. Rivas Pollmar, A. González Ceberino, N. V. Butta, V. Jiménez Yuste Hematology, La Paz University Hospital, Madrid, Spain Background: Platelet destruction and suppression of platelet production are involved in immu...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The synergic action of Ven and Sil was analyzed by the Chou-Talalay combination index (CI) method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "synergic", "action", "of", "Ven...
PMC11770199	Their lower toxicity and tumor-homing characteristics make them more feasible for achieving intravenous administration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Their", "lower", "toxicity", "and", "tumor-homing", "characteristics", ...
PMC11474209	The immunological sensor in ICTS used quantum dots as the fluorescent dye due to their good optical and electrical characteristics and extremely limited emission wavelength.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11489351	Cells were incubated at 37 °C for 10 min, and the plate was read again with the same parameters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "...
PMC10114490	D mRNA levels of genes involved in GSH metabolism (KEGG: glutathione_metabolism).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "mRNA", "levels", "of", "genes", "involved", "in", "GSH", ...
PMC10606998	These processes must obviously depend on the type of irradiation, the size and material of the nanoparticle core, and the material and thickness of its organic shell, as well as on the cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794568	The wounds were observed and photographed under a microscope at 0 h and 72 h, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "wounds", "were", "observed", "and", ...
PMC11632064	Although no highly selective BCL2A1 inhibitor has yet been identified (Li et al, 2021), a few inhibitors have shown promising results in experimental cancer studies (D de Araujo et al, 2018; Haq et al, 2013b), including the BET inhibitor CPI-0610, which indirectly targets the transcription of BCL2A1 (Yamatani et al, 20...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9712534	The ATPase and core domains of human TOP2A and TOP2B share high sequence similarity, and the C-terminal regions are less conserved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ATPas...
PMC9599726	We conclude that RSL3 is a potent ferroptosis inducer in both GIST882 and GIST48 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "We", "conclude", "that", "RSL3", "is", "a", ...
PMC11787355	h Untargeted ligandomics of primary glioblastoma cell lines with overlapping of PTPRZ1 ligands across primary glioblastoma cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "h", "Untargeted", "ligandomics", "of", ...
PMC9429973	Preceptorships on SCD will be launched soon.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Preceptorships", "on", "SCD", "will", "be", "launched", "soon", "." ] } ]
PMC2118063	This suggested that the pattern of IRF8 expression seen with mouse lymphoma subsets was likely to reflect differences related to the differentiative state of the cell of origin rather than a mechanistic contribution to transformation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697703	Data are represented as mean ± SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "represented", "as", "mean", "±", "SEM", "." ] } ]
PMC9429973	Methods: We conducted a retrospective cohort study of adult patients with newly diagnosed AML who were treated in our institution between January 2009 and December 2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11577421	Notably, albumin interacts with the cellular glycocalyx, a phenomenon particularly studied in endothelial cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "albumin", "interacts", "with", "the", ...
PMC11767725	Articles were initially screened based on their titles and abstracts to assess relevance, followed by full-text reviews for those meeting the inclusion criteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9621239	The clones with the recombination of genotype B and C were found in patient 13 and counted as genotype B. Chi-square test was used to compare the difference of genotype distribution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10502403	To assess the dependence on glucose metabolism, examinations of cytokine secretion by γδ-T cells using metabolic inhibitors were performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "assess", "the", ...
PMC9429973	Similarly, hepatomegaly appeared first in >90% of adults compared to <50% of children.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "hepatomegaly", "appeared",...
PMC11696659	After reviewing the abstracts, we identified 9 articles directly related to the study of telomere length and lung cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "reviewing", "the", ...
PMC10729469	E Quantification of F-FDG PET brain glucose uptake on the day of sacrifice (n = 5—6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "Quantification", "of", "F-FDG", "...
PMC11725127	The USP2 knockout-induced cell proliferation inhibition was abrogated by KRAS overexpression in RPMI 8226 cells (n = 3). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC8998437	However, in Akuba cell line (the early passage type II BL cell line), only a small fraction of cells (~8.4%) carried CCR1.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2614416	Nanotrap analytical column (CL5/61241/00): 5 μm 200 Ǻ Magic C18 75 μm × 150 mm. •	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nanotrap", "analytical", "column", "(", ...
PMC11637284	Throughout our study we consistently observe multiple bands for the various TAC60 variants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Throughout", "our", "study", "we", "consistently", "observe", "multiple", "...
PMC11770746	It is noteworthy that, under the conditions used, the in vivo percent TGI of cisplatin is higher than paclitaxel (41% vs 27%), although its in vitro IC50 value in the same CT26 cancer cells is ∼15-fold higher (5.89 μM vs 0.384 μM), reinforcing the importance of performing in vivo studies. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679033	Data were taken from at least two independent experiments (each treatment performed in duplicate or triplicate) and plotted as a percentage of LDH release compared to the determined maximal LDH release, according to the manufacturer’s calculation protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6487404	It is of note that cyclosporine inhibits CYP3A4, P-glycoprotein, and OATP1B1 (9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "of", "note", "that", "cyclosporine", ...
PMC9429973	Follow-up swabs were performed in 21 pts, 18 converted to negative after a mean of 23.4 days (SD +/- 8,4) from the first nasal swab and in 3 it still remained positive after 37, 40 and 45 days respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9817179	Single-molecule data from the PA-JF646 channel was analyzed using a SLIMfast (Normanno et al., 2015), a GUI based on a MATLAB implementation of the MTT algorithm (Sergé et al., 2008), and is available in the supplemental materials of Teves et al., 2016.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: To model kinase-independent functions of Cdk6 in Acute Lymphoblastic Leukemia (ALL), mouse pre/pro B-cell lines were generated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":...
PMC11747949	Similarly divergent response was identified in the analysis of adhesion proteins (PECAM‐1, LECAM‐2, gp40, cadherin 1 (CD324) are decreased in response to CCR2 antagonist in hypoxia, but increased in normoxia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8193046	The aromatic substructures 1,2,4-oxadiazole and 1,3,4-thiadiazole were extended to (i) isoxazole, (ii) oxazole, (iii) imidazole, (iv) furan, (v) thiazole, (vi) pyrazole, and (vii) thiophene, and added to the extended positive hit list.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10944868	ND, not determined.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "ND", ",", "not", "determined", "." ] } ]
PMC9429973	CECT response remained prognostic for PFS only.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CECT", "response", "remained", "prognostic", "for", "PFS", "only", "." ] } ]
PMC11794847	For histological analysis, tumor sections were stained with an anti-Ki67 antibody to assess cellular proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "histological", "analysis", ",", "tumor", "secti...
PMC10777969	Small molecules belonging to carbohydrate derivatives are such potential candidates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Small", "molecules", "belonging", "to", "carbohydrate", "derivatives", "are", "such", "potential", ...
PMC8557138	Endothelial cells are quiescent in a normal physiological state and survive with minimal metabolic needs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Endothelial", "cells", "are", "quiescent", "in", "a", "norm...
PMC9275501	HA can modify the surface of liposomes to give them targeting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HA", "can", "modify", "the", "surface", "of", "liposomes", "to", "give", "them", ...
PMC11790971	A 15-day ambr®15 (Sartorius Stedim Biotech) production run was performed to quantify their process performances and the measurements for production phenotypes, including Viable Cell Concentration (VCC), Peak Titre, and Specific Productivity Rate (SPR), are reported in Table S1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11488203	Data represent the mean ± s.d. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represent", "the", "mean", "±", "s.d", ".", "(" ] } ]
PMC11266100	Various electroporation buffers have been selected based on a review of various available electroporation-associated works involving gene transfer (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Various", "e...
PMC11001582	f, qPCR analysis of COL6A1 transcript levels normalized to GAPDH at DIV 5 (left panel) and DIV 7 (right panel) in (GR)50, or GFP-treated iNeurons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11222184	The expressions of cell cycle-related genes AURKA, CCND3, CDC20, E2F4, MCM2 and STMN1 changed with XL-888 administration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expressions", ...
PMC10968586	OLE and HT activity against solid tumor insurgence and development has been challenged in a large number of experimental models, both in vivo and in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8584319	7 × 10 MEFs or 3 × 10 HepG2 cells seeded in 48-well plates were incubated overnight and then treated with various concentrations of AZD8055.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11394386	In addition, the potential role of the lncRNAs as biomarkers of prognosis, treatment response and therapeutic targets is becoming increasingly important.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11266100	For the ESOPE protocol (1.2 kV/cm x 100 µs × 8) the differences are low with both cell lines experiencing high permeabilization, although the difference is more profound in the nanosecond range.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Pts received dara SC 1800 mg per approved schedule and tal (400 μg/kg weekly or 800 μg/kg Q2W) with step-up dosing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", ...
PMC8740518	The color scale indicates the relative expression levels of the metabolites across all samples, blue represents an expression less than the mean, while red represents a higher expression level greater than the mean. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540692	The results were expressed as N-fold differences in gene expression relative to the TBP gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "were", "expressed", "as", "N-fold", "diff...
PMC11615828	According to the design and features, we named this tool RIVET (Rapid Immobilization of target Vesicles on Engaged Tracks).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", ...
PMC5308810	CXCR4-KLA displays the preferential cell killing of CXCR4 compared to CXCR4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CXCR4-KLA", "displays", "the", "preferential", "cell", "killing", "of", "CXCR4", "compared"...
PMC11711063	Single‐cell image analysis was performed using CellProfiler.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single‐cell", "image", "analysis", "was", "performed", "using", "CellProfiler", "." ] } ]
PMC10040136	The PDGFD mRNA forward primer was GCGGCTTCACTCTCAGGAGAAT, and the PDGFD mRNA reverse primer was CTTGTGTCCACACCATCGTCCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PDGFD", "mRNA", "forward", "primer", "was", ...
PMC10840195	The apoptosis of A498 cells and SR-A498 cells was determined by flow cytometry (B).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "apoptosis", "of", "A498", "cells", ...
PMC9672323	The effect of dexamethasone and piroxicam was measured on the IFN-γ levels of T cells in PBMCs alone (a, c), and in co-culture with U-87 (b) (n = 5), and A-172 (d) (n = 4) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11496728	To explore the effect of regulatory elements on the expression of recombinant proteins, eGFP was replaced with SEAP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "explore", "the", "effect", ...
PMC9813422	HBV virions infect hepatocytes, and then the relaxed circular DNA (rcDNA) is transported to the nucleus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HBV", "virions", "infect", "hepat...
PMC9429973	Compared with AELN risk classification, AMLOS score model was more superior in both sensitivity and applicability with the AUC value in AMLOS vs. AELN alone of 0.716 vs. 0.693, 0.702 vs. 0.531 in training cohort and validation cohort, respectively (Fig. 1C, D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519583	Indeed, we confirmed that MP senescence was mitigated in glycerol-injected muscles compared with that in Ctx-injected muscles (Supplementary Fig. 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ","...
PMC7709199	Here, we present the use of the GlycoDelete (GD) HEK cell line for protein crystallization, which produces homogeneous mature-like trisaccharide glycan stubs (Meuris et al., 2014 ▸).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11258145	The sensitivity of cells to curcumin presence depends on the saturation level of their membranes; the more rigid the membrane, the lower the concentration of curcumin causes its disruption.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585565	Functional analysis also showed that this missense variant in LMNA affected the splicing process resulting in mRNA degradation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Functional", "analysis", "also", "showed", ...
PMC10253973	In developing countries, cancer is the second most common fatal disease after heart issues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "developing", "countries", ",", "cancer", "is", "the",...
PMC6461034	Using a minimal volume of peptide solution (≤ 5 μl), check for a pH ≥ 6 with a pH strip.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using",...
PMC11225860	At later stages of apoptosis, phosphatidylserine will be present, along with a high degree of cell membrane comprise, enabling the binding of both Annexin V and PI (double positive, C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11719944	This suggests that constant antigen presentation during the autoimmune process may cause an exhausted state, resulting in a decrease in effector response capacity, such as the secretion of granules and proinflammatory cytokines .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740508	Azacytidine is primarily incorporated into RNA, with about 20% converted to the cytosine analog 5-aza-2′-deoxycytidine for DNA incorporation in place of cytosine .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9822769	In fact, the ratio between AR 37°C and AR 4°C is 3.2 and 3.6 for 1 and 3 but increases hugely for cisplatin and especially for 2, indicating that active/facilitated transport contributes significantly to the overall uptake of the latter two complexes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11696659	Although telomere evaluation in peripheral blood lymphocytes is an attractive potential biomarker, as it is non-invasive, inexpensive, and quantifiable, high accuracy and standardization of measurements are essential for it to be useful .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422150	Six weeks after SCI induction, gait function was assessed using three-dimensional motion analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Six", "weeks", "after", "SCI", "induction", ",", "gait", "functi...
PMC7685376	Lipofectamine 2000 (Invitrogen, USA) was used to transfect the MCM and negative control siRNAs into the cells according to the manufacturer’s suggestions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11805741	∑1%: Molar extension coefficient at a concentration of 1%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∑1", "%", ":", "Molar", "extension", "coefficient", "at", "a", "concentration", ...
PMC11721587	Our previous study revealed that the SUMO pathway regulates Hh signaling by promoting Smo cell surface accumulation (43).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "previous", "study", ...
PMC9964635	The molecular bindings between the target and new derivatives were visualized in 2D using Discovery Studio Visualizer Software 2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "molecular", "bindings", "b...
PMC11271800	In a mouse model of lung cancer, the combination of anti-PD-1/PD-L1 with an anti-angiogenic drug (apatinib) improved TME, which enhanced the anti-tumor effects of PD-1/PD-L1 inhibitors by inducing polarization of M2 to M1 TAMs, which was validated in a later study of brain metastasis in lung cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10631132	Scale bar = 500 µm Immunocytochemistry in conjunction with confocal microscopy of the cell-forming complexes was performed to assess the differentiation process following mesodermal induction (Fig. 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10198699	The reason is that POPIA only applies to personal information that is ‘entered in a record by or for a responsible party’ [section 3(1)].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600253	Among the stilbene compounds, trans-resveratrol, also known as 3,4,5,’-tri-hydroxystilbene, and pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, which is a dimethylether analog of resveratrol), have been well-studied as promising dietary polyphenolic compounds with various chemopreventive and chemotherapeutic effe...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: At the clinical cut-off date of January 18, 2022, 35/113 (31.0%) pts in the overall population had received a COVID-19 vaccine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10957991	The mechanisms behind altered TRPV4 levels are poorly understood but at least stromal stiffening could play a role in this process due to the ability of TRPV4 to respond to the biophysical changes in its microenvironment, such as pressure and stiffness in some cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10419319	Glucose is mainly used in OC cells to produce ATP and to maintain redox homeostasis and energy balance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glucose", "is", "mainly", "used", "in"...
PMC9512971	Dosing—Prior to this study, we conducted a phase 1 study to set the dosage and treatment regimen for this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dosing"...
PMC8903741	Accordingly, we seeded a low concentration of cells for three days post transfection and added G-418.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accordingly", ",", "we", "seeded", "a", "lo...
PMC7612475	Critically, we show that the cancer-associated SF3B1 mutation causes the accumulation of unscheduled R-loops that triggers replication fork stalling and collapse.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Critically", ...
PMC10507284	Hence, the above evidence distinguished that TROAP could arrest the cell cycle of STS cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "the", "above", "evidence", "distinguishe...
PMC10926885	Given that NDE1 significantly positively correlates with almost all of the known immune checkpoint genes, it is clear that NDE1 is connected to immunity against cancer tumours (Figure 6D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8073654	When paclitaxel (25 mg/kg) was orally administered with 2 (5 mg/kg), its relative bioavailability was improved by 185% due to the oral exposure of paclitaxel through the inhibition of the intestinal P-gp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10079526	We observed a significant reduction in colony formation for homologous recombination deficient cells in response to combination treatment compared to wild-type cells, indicating that homologous recombination is required for repair of the induced DNA double strand breaks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680578	It has also been found that PTX can reduce the levels of vascular endothelial growth factor (VEGF) in tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "also...
PMC11727145	The present study successfully standardized and optimized the DED model for evaluating clinical cutaneous cell therapies, highlighting the importance of insulin and EGF in culture media for promoting keratinocyte proliferation/function in this model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	of 107 patients with AML (73 males, 34 females, 68 mean age) were recorded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "of", "107", "patients", "with", "AML",...
PMC11530949	In contrast, the IC50 value for the Ag-doped CuO NPs synthesized by Ephedra intermedia was significantly lower, at 11.5 µg/mL. This drastic reduction in IC50 values demonstrates the enhanced cytotoxic efficiency of the NPs compared to the plant extract alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11661024	Hence, there is a need for a balancing connection between the urogenital system microbiome and the host immune system to support healthy urogenital system homeostasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8073654	enhanced hippocampal neurogenesis in olfactory bulbectomy (OBX)-induced mice and increased the number of 5-bromo-2′-deoxyuridine (BrdU)/NeuN (a neuronal marker) double-labeled cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "enhanced", "...

PMC9429973

All of them occurred during the first time of infusion.

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PMC11611077

CHO cells transfected with prestin and untransfected CHO cells were fixed with 4% paraformaldehyde in phosphate buffer at room temperature for 5 min and washed with PBS.

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PMC9429973

E. Monzón Manzano, M. T. Alvarez Román, P. Acuña, E. G. Arias Salgado, A. Ramírez, M. Martín Salces, M. I. Rivas Pollmar, A. González Ceberino, N. V. Butta, V. Jiménez Yuste Hematology, La Paz University Hospital, Madrid, Spain Background: Platelet destruction and suppression of platelet production are involved in immu...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The synergic action of Ven and Sil was analyzed by the Chou-Talalay combination index (CI) method.

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PMC11770199

Their lower toxicity and tumor-homing characteristics make them more feasible for achieving intravenous administration .

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PMC11474209

The immunological sensor in ICTS used quantum dots as the fluorescent dye due to their good optical and electrical characteristics and extremely limited emission wavelength.

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PMC11489351

Cells were incubated at 37 °C for 10 min, and the plate was read again with the same parameters.

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PMC10114490

D mRNA levels of genes involved in GSH metabolism (KEGG: glutathione_metabolism).

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PMC10606998

These processes must obviously depend on the type of irradiation, the size and material of the nanoparticle core, and the material and thickness of its organic shell, as well as on the cell line.

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PMC11794568

The wounds were observed and photographed under a microscope at 0 h and 72 h, respectively.

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PMC11632064

Although no highly selective BCL2A1 inhibitor has yet been identified (Li et al, 2021), a few inhibitors have shown promising results in experimental cancer studies (D de Araujo et al, 2018; Haq et al, 2013b), including the BET inhibitor CPI-0610, which indirectly targets the transcription of BCL2A1 (Yamatani et al, 20...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9712534

The ATPase and core domains of human TOP2A and TOP2B share high sequence similarity, and the C-terminal regions are less conserved.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ATPas...

PMC9599726

We conclude that RSL3 is a potent ferroptosis inducer in both GIST882 and GIST48 cells.

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PMC11787355

h Untargeted ligandomics of primary glioblastoma cell lines with overlapping of PTPRZ1 ligands across primary glioblastoma cell lines.

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PMC9429973

Preceptorships on SCD will be launched soon.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Preceptorships", "on", "SCD", "will", "be", "launched", "soon", "." ] } ]

PMC2118063

This suggested that the pattern of IRF8 expression seen with mouse lymphoma subsets was likely to reflect differences related to the differentiative state of the cell of origin rather than a mechanistic contribution to transformation.

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PMC11697703

Data are represented as mean ± SEM.

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PMC9429973

Methods: We conducted a retrospective cohort study of adult patients with newly diagnosed AML who were treated in our institution between January 2009 and December 2021.

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PMC11577421

Notably, albumin interacts with the cellular glycocalyx, a phenomenon particularly studied in endothelial cells.

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PMC11767725

Articles were initially screened based on their titles and abstracts to assess relevance, followed by full-text reviews for those meeting the inclusion criteria.

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PMC9621239

The clones with the recombination of genotype B and C were found in patient 13 and counted as genotype B. Chi-square test was used to compare the difference of genotype distribution.

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PMC10502403

To assess the dependence on glucose metabolism, examinations of cytokine secretion by γδ-T cells using metabolic inhibitors were performed.

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PMC9429973

Similarly, hepatomegaly appeared first in >90% of adults compared to <50% of children.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "hepatomegaly", "appeared",...

PMC11696659

After reviewing the abstracts, we identified 9 articles directly related to the study of telomere length and lung cancer.

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PMC10729469

E Quantification of F-FDG PET brain glucose uptake on the day of sacrifice (n = 5—6).

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PMC11725127

The USP2 knockout-induced cell proliferation inhibition was abrogated by KRAS overexpression in RPMI 8226 cells (n = 3). (

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PMC8998437

However, in Akuba cell line (the early passage type II BL cell line), only a small fraction of cells (~8.4%) carried CCR1.

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PMC2614416

Nanotrap analytical column (CL5/61241/00): 5 μm 200 Ǻ Magic C18 75 μm × 150 mm. •

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PMC11637284

Throughout our study we consistently observe multiple bands for the various TAC60 variants.

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PMC11770746

It is noteworthy that, under the conditions used, the in vivo percent TGI of cisplatin is higher than paclitaxel (41% vs 27%), although its in vitro IC50 value in the same CT26 cancer cells is ∼15-fold higher (5.89 μM vs 0.384 μM), reinforcing the importance of performing in vivo studies. (

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PMC11679033

Data were taken from at least two independent experiments (each treatment performed in duplicate or triplicate) and plotted as a percentage of LDH release compared to the determined maximal LDH release, according to the manufacturer’s calculation protocol.

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PMC6487404

It is of note that cyclosporine inhibits CYP3A4, P-glycoprotein, and OATP1B1 (9).

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PMC9429973

Follow-up swabs were performed in 21 pts, 18 converted to negative after a mean of 23.4 days (SD +/- 8,4) from the first nasal swab and in 3 it still remained positive after 37, 40 and 45 days respectively.

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PMC9817179

Single-molecule data from the PA-JF646 channel was analyzed using a SLIMfast (Normanno et al., 2015), a GUI based on a MATLAB implementation of the MTT algorithm (Sergé et al., 2008), and is available in the supplemental materials of Teves et al., 2016.

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PMC9429973

Methods: To model kinase-independent functions of Cdk6 in Acute Lymphoblastic Leukemia (ALL), mouse pre/pro B-cell lines were generated.

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PMC11747949

Similarly divergent response was identified in the analysis of adhesion proteins (PECAM‐1, LECAM‐2, gp40, cadherin 1 (CD324) are decreased in response to CCR2 antagonist in hypoxia, but increased in normoxia.

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PMC8193046

The aromatic substructures 1,2,4-oxadiazole and 1,3,4-thiadiazole were extended to (i) isoxazole, (ii) oxazole, (iii) imidazole, (iv) furan, (v) thiazole, (vi) pyrazole, and (vii) thiophene, and added to the extended positive hit list.

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PMC10944868

ND, not determined.

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PMC9429973

CECT response remained prognostic for PFS only.

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PMC11794847

For histological analysis, tumor sections were stained with an anti-Ki67 antibody to assess cellular proliferation.

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PMC10777969

Small molecules belonging to carbohydrate derivatives are such potential candidates.

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PMC8557138

Endothelial cells are quiescent in a normal physiological state and survive with minimal metabolic needs.

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PMC9275501

HA can modify the surface of liposomes to give them targeting.

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PMC11790971

A 15-day ambr®15 (Sartorius Stedim Biotech) production run was performed to quantify their process performances and the measurements for production phenotypes, including Viable Cell Concentration (VCC), Peak Titre, and Specific Productivity Rate (SPR), are reported in Table S1.

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PMC11488203

Data represent the mean ± s.d. (

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PMC11266100

Various electroporation buffers have been selected based on a review of various available electroporation-associated works involving gene transfer (Table 1).

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PMC11001582

f, qPCR analysis of COL6A1 transcript levels normalized to GAPDH at DIV 5 (left panel) and DIV 7 (right panel) in (GR)50, or GFP-treated iNeurons.

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PMC11222184

The expressions of cell cycle-related genes AURKA, CCND3, CDC20, E2F4, MCM2 and STMN1 changed with XL-888 administration.

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PMC10968586

OLE and HT activity against solid tumor insurgence and development has been challenged in a large number of experimental models, both in vivo and in vitro.

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PMC8584319

7 × 10 MEFs or 3 × 10 HepG2 cells seeded in 48-well plates were incubated overnight and then treated with various concentrations of AZD8055.

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PMC11394386

In addition, the potential role of the lncRNAs as biomarkers of prognosis, treatment response and therapeutic targets is becoming increasingly important.

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PMC11266100

For the ESOPE protocol (1.2 kV/cm x 100 µs × 8) the differences are low with both cell lines experiencing high permeabilization, although the difference is more profound in the nanosecond range.

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PMC9429973

Pts received dara SC 1800 mg per approved schedule and tal (400 μg/kg weekly or 800 μg/kg Q2W) with step-up dosing.

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PMC8740518

The color scale indicates the relative expression levels of the metabolites across all samples, blue represents an expression less than the mean, while red represents a higher expression level greater than the mean. (

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PMC8540692

The results were expressed as N-fold differences in gene expression relative to the TBP gene.

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PMC11615828

According to the design and features, we named this tool RIVET (Rapid Immobilization of target Vesicles on Engaged Tracks).

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PMC5308810

CXCR4-KLA displays the preferential cell killing of CXCR4 compared to CXCR4.

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PMC11711063

Single‐cell image analysis was performed using CellProfiler.

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PMC10040136

The PDGFD mRNA forward primer was GCGGCTTCACTCTCAGGAGAAT, and the PDGFD mRNA reverse primer was CTTGTGTCCACACCATCGTCCT.

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PMC10840195

The apoptosis of A498 cells and SR-A498 cells was determined by flow cytometry (B).

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PMC9672323

The effect of dexamethasone and piroxicam was measured on the IFN-γ levels of T cells in PBMCs alone (a, c), and in co-culture with U-87 (b) (n = 5), and A-172 (d) (n = 4) cells.

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PMC11496728

To explore the effect of regulatory elements on the expression of recombinant proteins, eGFP was replaced with SEAP.

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PMC9813422

HBV virions infect hepatocytes, and then the relaxed circular DNA (rcDNA) is transported to the nucleus.

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PMC9429973

Compared with AELN risk classification, AMLOS score model was more superior in both sensitivity and applicability with the AUC value in AMLOS vs. AELN alone of 0.716 vs. 0.693, 0.702 vs. 0.531 in training cohort and validation cohort, respectively (Fig. 1C, D).

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PMC11519583

Indeed, we confirmed that MP senescence was mitigated in glycerol-injected muscles compared with that in Ctx-injected muscles (Supplementary Fig. 8).

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PMC7709199

Here, we present the use of the GlycoDelete (GD) HEK cell line for protein crystallization, which produces homogeneous mature-like trisaccharide glycan stubs (Meuris et al., 2014 ▸).

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PMC11258145

The sensitivity of cells to curcumin presence depends on the saturation level of their membranes; the more rigid the membrane, the lower the concentration of curcumin causes its disruption.

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PMC11585565

Functional analysis also showed that this missense variant in LMNA affected the splicing process resulting in mRNA degradation.

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PMC10253973

In developing countries, cancer is the second most common fatal disease after heart issues.

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PMC6461034

Using a minimal volume of peptide solution (≤ 5 μl), check for a pH ≥ 6 with a pH strip.

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PMC11225860

At later stages of apoptosis, phosphatidylserine will be present, along with a high degree of cell membrane comprise, enabling the binding of both Annexin V and PI (double positive, C).

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PMC11719944

This suggests that constant antigen presentation during the autoimmune process may cause an exhausted state, resulting in a decrease in effector response capacity, such as the secretion of granules and proinflammatory cytokines .

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PMC11740508

Azacytidine is primarily incorporated into RNA, with about 20% converted to the cytosine analog 5-aza-2′-deoxycytidine for DNA incorporation in place of cytosine .

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PMC9822769

In fact, the ratio between AR 37°C and AR 4°C is 3.2 and 3.6 for 1 and 3 but increases hugely for cisplatin and especially for 2, indicating that active/facilitated transport contributes significantly to the overall uptake of the latter two complexes.

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PMC11696659

Although telomere evaluation in peripheral blood lymphocytes is an attractive potential biomarker, as it is non-invasive, inexpensive, and quantifiable, high accuracy and standardization of measurements are essential for it to be useful .

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PMC11422150

Six weeks after SCI induction, gait function was assessed using three-dimensional motion analysis.

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PMC7685376

Lipofectamine 2000 (Invitrogen, USA) was used to transfect the MCM and negative control siRNAs into the cells according to the manufacturer’s suggestions.

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PMC11805741

∑1%: Molar extension coefficient at a concentration of 1%.

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PMC11721587

Our previous study revealed that the SUMO pathway regulates Hh signaling by promoting Smo cell surface accumulation (43).

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PMC9964635

The molecular bindings between the target and new derivatives were visualized in 2D using Discovery Studio Visualizer Software 2021.

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PMC11271800

In a mouse model of lung cancer, the combination of anti-PD-1/PD-L1 with an anti-angiogenic drug (apatinib) improved TME, which enhanced the anti-tumor effects of PD-1/PD-L1 inhibitors by inducing polarization of M2 to M1 TAMs, which was validated in a later study of brain metastasis in lung cancer.

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PMC10631132

Scale bar = 500 µm Immunocytochemistry in conjunction with confocal microscopy of the cell-forming complexes was performed to assess the differentiation process following mesodermal induction (Fig. 3).

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PMC10198699

The reason is that POPIA only applies to personal information that is ‘entered in a record by or for a responsible party’ [section 3(1)].

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PMC6600253

Among the stilbene compounds, trans-resveratrol, also known as 3,4,5,’-tri-hydroxystilbene, and pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, which is a dimethylether analog of resveratrol), have been well-studied as promising dietary polyphenolic compounds with various chemopreventive and chemotherapeutic effe...

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PMC9429973

Results: At the clinical cut-off date of January 18, 2022, 35/113 (31.0%) pts in the overall population had received a COVID-19 vaccine.

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PMC10957991

The mechanisms behind altered TRPV4 levels are poorly understood but at least stromal stiffening could play a role in this process due to the ability of TRPV4 to respond to the biophysical changes in its microenvironment, such as pressure and stiffness in some cell types.

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PMC10419319

Glucose is mainly used in OC cells to produce ATP and to maintain redox homeostasis and energy balance.

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PMC9512971

Dosing—Prior to this study, we conducted a phase 1 study to set the dosage and treatment regimen for this study.

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PMC8903741

Accordingly, we seeded a low concentration of cells for three days post transfection and added G-418.

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PMC7612475

Critically, we show that the cancer-associated SF3B1 mutation causes the accumulation of unscheduled R-loops that triggers replication fork stalling and collapse.

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PMC10507284

Hence, the above evidence distinguished that TROAP could arrest the cell cycle of STS cells.

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PMC10926885

Given that NDE1 significantly positively correlates with almost all of the known immune checkpoint genes, it is clear that NDE1 is connected to immunity against cancer tumours (Figure 6D).

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PMC8073654

When paclitaxel (25 mg/kg) was orally administered with 2 (5 mg/kg), its relative bioavailability was improved by 185% due to the oral exposure of paclitaxel through the inhibition of the intestinal P-gp.

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PMC10079526

We observed a significant reduction in colony formation for homologous recombination deficient cells in response to combination treatment compared to wild-type cells, indicating that homologous recombination is required for repair of the induced DNA double strand breaks.

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PMC11680578

It has also been found that PTX can reduce the levels of vascular endothelial growth factor (VEGF) in tumors.

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PMC11727145

The present study successfully standardized and optimized the DED model for evaluating clinical cutaneous cell therapies, highlighting the importance of insulin and EGF in culture media for promoting keratinocyte proliferation/function in this model.

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PMC9429973

of 107 patients with AML (73 males, 34 females, 68 mean age) were recorded.

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PMC11530949

In contrast, the IC50 value for the Ag-doped CuO NPs synthesized by Ephedra intermedia was significantly lower, at 11.5 µg/mL. This drastic reduction in IC50 values demonstrates the enhanced cytotoxic efficiency of the NPs compared to the plant extract alone.

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PMC11661024

Hence, there is a need for a balancing connection between the urogenital system microbiome and the host immune system to support healthy urogenital system homeostasis.

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PMC8073654

enhanced hippocampal neurogenesis in olfactory bulbectomy (OBX)-induced mice and increased the number of 5-bromo-2′-deoxyuridine (BrdU)/NeuN (a neuronal marker) double-labeled cells .

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