OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10847511	These findings highlight the limitations of drug and biomarker discovery research based on existing cell line databases and emphasize the need for caution when interpreting results obtained from such sources.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9503685	Cells were cultured in Dulbecco’s Modified Eagle Medium (DMEM) supplemented with 10% Fetal Bovine Serum (FBS), 2 mM L-glutamine and 1% penicillin-streptomycin solution and incubated at 37 °C in a humidified atmosphere with 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Mutations of TP53 in JAK2V617F patients are linked to AML transformation, illustrated by development of leukemias after retroviral overexpression of JAK2V617F in TP53 inactivated (KO) cells transplanted in irradiated animals, thus a possible cooperation between TP53 inactivation and JAK2 signaling in transformation pro...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11696576	LTB4 showed the greatest induction versus unstimulated control in this cell type with an 18-fold increase versus between a 4-to-6-fold increase for the other eicosanoids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC3675084	Together, the results show that efflux transporter P-gp contributed to the selected paclitaxel resistance in SKOV-3-TR and OVCAR-3-TR cells, but BPR0L075 is not a substrate for efflux pumps, which contributes to its ability to overcome paclitaxel resistance. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "...
PMC11413393	c Western blot analysis of asymmetric dimethylarginine (aDMA) changes in 786-0 and RCC243 cells after MS023 treatment using the ASYM25 antibody for indicated period of time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC11441402	One-way ANOVA analysis with Tukey’s multiple comparisons was used to compare GI50 and LC50 values calculated for each assay, where p < 0.05 was considered statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7917457	OVs can induce tumor cell killing through direct lysis of infected tumor cells or through induction of a strong antiviral immune response, leading to the elimination of OV-infected cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: This is a quantitative study; a cross-sectional survey was conducted among Tunisian youths (n = 182; male 23,3 %, female 76,7 %).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742670	MAE comparison for testing and training datasets to predict IC50 on three different cell lines. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MAE", "comparison", "for", "testing", "and", "training...
PMC6364197	This could be attributed to the similar morphology of the PCL scaffolds to the bone marrow, as collagen type I helps in cell chemoresistance by activating DDR1 (36).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: In our local DLBCL population treated with immunochemotherapy the COO according to the Hans algorithm, despite the small number, was suprinsingly found to be a significant independent prognostic factor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11389534	Deeper exploration is necessary to unravel the exact molecular mechanisms that govern its diverse functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Deeper", "exploration", "is", "necessary", "to", "unravel", ...
PMC11656048	CHX is a kind of inhibitor of protein synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CHX", "is", "a", "kind", "of", "inhibitor", "of", "protein", "synthesis", "." ] } ]
PMC4485786	Besides its role in T-cell priming, IL-12 efficiently reverts T helper (TH)17 cells back into a TH1 phenotype, restores M1 macrophage function, and mediates dendritic cell (DC)-NK interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Mean fluorescence intensity (MFI) cutoffs (ECL: MFI=1.43; RCA: MFI=1.10) were calculated based on HCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mean", "fluorescence", ...
PMC11301242	Annotation and (B) functional enrichment analysis of ecDNA amplicon peaks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Annotation", "and", "(", "B", ")", "functional", "enrichment", "analysis", "of",...
PMC11721587	These observations suggest that the nuclear Ci-Sufu-Fu complex may contribute to Ci function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "observations", "suggest", "that", "the", "nuclear", "Ci-Sufu-Fu", ...
PMC11632064	We examined the data from this study to determine whether our candidate genes for the mitochondrial resistance signature were included.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "examined", "the", ...
PMC11026382	Error bars in x indicate the standard deviation across N = 3 experimental replicates, error bars in y describe the standard deviation obtained by jackknife (leave-one-out) sub-sampling the data and refitting the model ten times (all points centered at the mean).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6889484	Viruses from peak production, normalized for p24 CA, from round 1 cultures 100% CEM (day 7; indicated by a blue star in A), 50%CEM:50%CEM/D128K (day 9; indicated by a red star in A), and 25% CEM:75% CEM/D128K (day 12; indicated by a green star in A) were used to infect either 100% CEM or 100% CEM/D128K cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679033	Some authors did not find significant DNA damaging effect of CIT using comet assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "authors", "did", "not", "find", "significant", "DNA", "d...
PMC8041314	However, the simultaneous targeting of ABCB1, ABCC1, and ABCG2 has only very recently been emphasized.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "simultaneous", ...
PMC9429973	In patients with a partial response (PR) to treatment, the number of positive cells was statistically significantly higher than in patients with CR: 80% (58-88) vs. 24% (8-42), respectively, p<0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: The aim of this study was to use the combination of CRISPR/Cas9 screening and high-throughput drug screening on cells with introduced SF3B1 or NOTCH1 mutations in order to reveal unique vulnerabilities specific to the cells carrying these frequent CLL mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543935	The rapid evolution of medical technologies and devices, coupled with the growing shift towards alternatives to animal models, like the Directive 2010/63/EU of the European Parliament which was implemented as “an important step towards achieving the final goal of full replacement of procedures on live animals for scien...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10530622	In mice with obesity induced by leptin deficiency, Amin et al., 2018 observed hyperoxaluria compared to lean control animals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "mice", "wit...
PMC9429973	When asked how much they were bothered by treatment side effects, a majority of patients reported “a little bit” or “not at all” at most cycles (71%-89% in the high-risk group and 46%-86% in the non–high-risk group).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6642070	p53 and β-enolase protein in A-204 cells exposed to atorvastatin (Atr), pitavastatin (Pit), simvastatin (Sim), rosuvastatin (Ros), and lovastatin (Lov) at 10 μM for 48 h. (g) p53 and β-enolase protein in A-204 cells after lentivirus-mediated knockdown of HMGCR. (	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594641	Ribonucleoprotein was added to the transfection reagent, previously diluted in Opti-MEM, and incubated for 5–10 min at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ribonucleoprotein", "wa...
PMC8041314	Screening of a virtual compound library for novel broad-spectrum ABCB1, ABCC1, and ABCG2 inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Screening", "of", "a", "virtual", "compound", "library...
PMC11049548	Analyzing metabolic profiles from ex vivo primary cell cultures post six cycles of platinum-based chemotherapy would be of high interest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Analyzing", "metabolic", "pr...
PMC11247842	Putative causal genes were called as genes found by nearest gene or gene-analysis that are also supported by gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, or/and mammalian phenotype database (MPD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10093184	As osteosarcomas represent a very heterogeneous malignancy and the number of available canine osteosarcoma cell lines is limited, their further de novo isolation and characterization are necessary to span the variability of the naturally occurring tumor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461833	In addition, we also overexpressed lamin A in HEK293 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "In", "addition", ",", "we", "also", "overexpressed", "lamin", "A", "in", "HE...
PMC11746948	Furthermore, pharmacologically modulating GPX4 palmitoylation impacts liver ischemia–reperfusion injury.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "pharmacologically", "modulating", "GPX4", "palmitoylation", "impacts", ...
PMC6617630	a–c WT-MYC, SH, DHL, THL, and BCL-2/BCL-6 translocation harboring cell lines were treated with 3 different pharmacological BET bromodomain inhibitors I-BET (a), JQ1 (b), and OTX (c) for 72 h and cell survival was assessed by flow cytometry after annexin V/PI staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8916024	Differences in α-index among the three groups were assessed with the Kruskal–Wallis H test and Tukey HSD test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differences", "in", "α-index...
PMC11597167	The results are presented in Figure 1 and tabulated in Table 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "are", "presented", "in", "Figure", "1", "and", "tabulated", ...
PMC10142392	Multiple branch compositions also exhibit low critical micelle concentrations, high loading capacity, and controlled release of the cargo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multiple", "branch", "compos...
PMC11536589	Representative images were shown here and other images were represented in Supplementary Fig. 5A.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "were", "shown", "here", "and", "other", ...
PMC9429973	Findings derived from cytogenetics and molecular characterization in these patients are shown in Figure1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Findings", "derived", "from", "cytogenetics", "and", "molecular", "cha...
PMC10728200	However, Ferrostatin-1 itself did not affect ROS and lipid-ROS levels (Fig. S3 and 1D, E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "Ferrostatin-1", "...
PMC10956161	Immunohistochemistry was used to verify the levels of expression of PRDX6 protein in samples of lung adenocarcinoma compared with normal adjacent tissue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunohistochemist...
PMC10932641	PCNA, proliferating cell nuclear antigen; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; NC, negative control; lncRNA, long noncoding RNA; SI, silent; OE, overexpressive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352666	The hallmark of EWS is the EWS-FLI1 fusion protein, which acts as a transcription factor, driving aberrant gene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "hallmark", ...
PMC11704834	Consistent with these results, TLE1 expression in A549 cells also conferred protection against the proliferation-inhibitory and apoptotic effects of the third generation EGFR-TKI osimertinib (Fig. S2A-D) and attenuated the antitumor effect of gefitinib in the EGFR-TKI sensitive, EGFR-mutant LUAD HCC827 cell line (Fig. ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11694346	As depicted in Fig. 8(a), the untreated cells (control group) exhibited negligible fluorescence, indicating lower inherent autofluorescence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "depict...
PMC9429973	One patient died of toxicity attributed to Gilteritinib (febrile neutropenia).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "patient", "died", "of", "toxicity", "attributed", "to", "Gilteritinib", "...
PMC9429973	The heterogeneous nature of the disease requires more flexible, potent and safer approaches to make T-cell based treatments available for AML patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC6901583	The abovementioned effects were assessed in the animal models as described in the materials section.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "abovementioned", "effects", "were", "assessed", "in", ...
PMC8753818	Statistical analyses of the data were done using GraphPad Prism 6.0, and the data were represented as mean ± S.E. Calculations of the level of significance (p) were done by Mann–Whitney U test, A p value less than 0.05 (p < 0.05) was considered statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746942	A Venn diagram showing overlap between upregulated ATAC-seq peaks in psoriasis patients and downregulated genes after TY treatment in HaCaT cells (10 μM TY and 25 μg/mL IL-6), including K16 and K17.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC11271800	In addition, since patients with advanced disease need to be treated with long-term imatinib and multiline TKIs, their anti-tumor immunity is suppressed and weakened, and ICIs should be administered as early in the disease as possible.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11244823	As shown in Fig 5, the posC1 serum precipitated all four antigens at values of up to 10 RLU, whereas the ELISA-negative serum No 62 precipitated more than two logarithmic scales less.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11703992	By integrating transcriptomic and MR analyses, we provided in-depth insights into significant genes in CD4+ Memory T cells in GCA and identified causal effects between DDIT4/ARHGAP15 and the occurrence of GCA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7887261	TRICL Transdisciplinary Research in Cancer of the Lung, CMC Combined Multivariate and Collapsing, KBAC Kernel-Based Adaptive Cluster, LoF loss of function, LC lung cancer, PF pulmonary function, OR odds ratio, CI confidence interval, o/e observed/expected. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11593713	Abbreviations: HAdV5—human adenovirus 5; HcoV-229E—human coronavirus 229E; HcoV-OC43—human coronavirus OC43; HRV A—human rhinovirus A; IU—international activity unit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6948907	Inhibition ratio of different concentrations was calculated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibition", "ratio", "of", "different", "concentrations", "was", "calculated", "." ] } ]
PMC11678448	Pasteurella is ubiquitous in animal populations and is generally considered a component of the commensal microbiota found in the oral cavity, nasopharynx, and respiratory tract .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11752767	Melanoma is among the most immunogenic malignancies expressing melanoma-differentiation antigens and neoantigens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Melanoma", "is", "among", "the", "most", "immunogenic", "malignancies", "expressing", ...
PMC11774747	Furthermore, alternative systems, such as those based on CD20 mimotopes, have also been explored as potential elimination markers, offering additional safety mechanisms (119, 120).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	pHRSIN-pSFFV-pPGK-Puro/Hygro USP43 expressing vector was transfected to 5 × 10 cells in six-well plates using Fugene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "pHRSIN-pSFFV-pPGK-Puro/Hygro", "USP43", "expressing", "vector", ...
PMC9429973	Of ptn started on 1st line IM, NIL, and DAS; 94%, 63% and 100% received the licensed doses (400 mg OD, 300 mg BD, and 100 mg OD), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11719944	T cells play a central role in regulating and initiating these responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "T", "cells", "play", "a", "central", "role", "in", "regulating", "and", "i...
PMC2193049	Therefore, the participation of two complementary and possibly overlapping proteolytic systems in antigen processing could be envisaged and would be compatible with our results obtained after treatment of melanoma cells with lactacystin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11026382	For the TYMS R166Q background the overall proportion of significant epistatic mutations was larger: while only 41 mutations (1%) showed significant negative epistasis, 851 mutations (28%) showed significant positive epistasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Universidad Complutense; Service of Hematology, Hospital La Paz, Madrid, Spain; Division of Hematology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America Background: Congenital dyserythropoietic anemia type III (CDA III) is one of the rarest types of CDA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10854447	Physicochemical and pharmacokinetic properties (Lipinski parameters) of compounds 7h, 7i, 7j, 7k, and 7l.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Physicochemical", "and", "ph...
PMC9429973	The median time to relapse post-ASCT was 6 (2-17) months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "time", "to", "relapse", "post-ASCT", "was", "6"...
PMC9429973	However, some donors had been found carrying malignant hematopathy-related mutation genes when they had a physical examination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "some", "donors", "had"...
PMC5839394	Findings from several studies reported that both the AgNPs and Ag released by AgNPs are involved in the mechanism of cytotoxicity in different ways: infact, AgNPs probably provide a perfect surface outside the mitochondria for the univalent reduction of oxygen to superoxide from electron through the electron transport ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10994876	To explore this, we assessed the production capacity of the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "explore", "this", ",", "we", "assessed", "the", "production", "capacity", ...
PMC8316344	D TRIB2 regulated TFRC expression in a PSMB5-independent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "TRIB2", "regulated", "TFRC", "expression", "in", "a", "PSMB5-independent", "manner", "." ] } ]
PMC10243817	Recently, we have discovered that the expression of Mex3 RNA-binding family member B (MEX3B) was significantly elevated in nasal epithelial cells in CRS (5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739696	Level of ROS generation within untreated (control) and Co3O4NPs-treated (303.80 µg/ml) melanoma A-375 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Level", "of", "ROS", "generation", ...
PMC9436459	Among albanol B (46), sanggenon D (128), and sanggenon B (165), 46 exhibited the best anti-inflammatory activity, which inhibited expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and suppressed production of pro-inflammatory cytokines and mediators in LPS-induced RAW264.7 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7433824	The incubator, in which the flasks were kept, had a humidified atmosphere of 5% CO2 at 37°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "incub...
PMC11723947	HLA-B7 WT or HP1γ-deficient human naive CD4 T cells were injected i.v.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HLA-B7", "WT", "or", "HP1γ-deficient", "human", "naive", "CD4", "T", "cells", ...
PMC9429973	However, the clinical significance of major DNA double strand break repair pathway Non-Homologous End Joining (NHEJ) in T cell acute lymphoblastic leukemia remains to be studied in detail.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	By co-immunoprecipitation, proximity-ligation assay (C) and Nanoluciferase experiments, we demonstrated the interaction between PHBs and the members of the eIF4F complex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10421378	Afterward, the microorganisms were transferred to a 15 mL Falcon conical tube containing 9 mL MRS broth and sealed with parafilm, and incubated for 24 h at 30 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	The accurate control over physicomechanical and biological characteristics of a bioprinted construct is possible using advanced 3D printing technologies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "accurate", "control", "ove...
PMC11607638	After tagging with a fluorescent protein KillerRed, confocal imaging confirmed localization of SKR in the plasma membrane of SKR‐KillerRed‐CHO‐K1 cells (Figure 4J).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11301095	Rifampin, although used in almost all survivor cases, is prone to interactions in combination therapy, affecting efficacy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rifampin", ",", "although", ...
PMC11589157	In conclusion, we have successfully generated a haplotype-resolved chromosome-level genome for the critically endangered northern white-cheeked gibbon, using the third-generation sequencing technologies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11298021	MTT assay on Jurkat cells showed that the viability of Jurkat cells was significantly reduced ‎after exposure to rapamycin in a dose- and time-dependent manner. (	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Eight out of nine responses were seen after the first cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eight", "out", "of", "nine", "responses", "were", "seen", "after", "the", "first", ...
PMC9119314	Selectivity index with respect to Hep G cells.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "Selectivity", "index", "with", "respect", "to", "Hep", "G", "cells", "." ] } ]
PMC11088135	We will perform these issues in the future.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "will", "perform", "these", "issues", "in", "the", "future", "." ] } ]
PMC9429973	Aims: The objective of this study is to better define the current survival landscape of CML and the long-term toxicities, so that we can have a better and updated understanding of the disease and the actual clinical practice in local, regional and global settings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11285179	For RDH13 and DHRS11 gene silence, pericytes were infected with negative control siRNAs, RDH13-targeting, or DHRS11-targeting siRNAs (genepharma).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...
PMC11413393	This deficit was comparable to that seen with the use of a DNA-dependent protein kinase (DNAPK) inhibitor, a well-characterized disruptor of DSB repair.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9545714	Tetrahydrofuran (THF) was purchased from Sigma Chemical Company (St. Louis MO).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tetrahydrofuran", "(", "THF", ")", "was", "purchased", "fro...
PMC9780037	In addition to PEGylation, ionic liquids have also been shown great value in extending cyt c thermal stability and shelf life.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "additi...
PMC9844987	prQTLs, dprQTLs, and frQTLs with FDR ≤5% were retained.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "prQTLs", ",", "dprQTLs", ",", "and", "frQTLs", "with", "FDR", "≤5", "%", ...
PMC7812570	Compared to the infectivity of HIV-1 strains produced from cells cotransfected with an empty vector (negative control), the infectivity of both HIV-1 NL4-3 and THRO.c/2626 produced from cells expressing GPI-m36.4 but not GPI-FluIgG03 was dramatically decreased (Fig. 7C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352666	These data indicate that EWS cells can be particularly dependent on MCL-1 for survival, especially if they express high levels of EWS-FLI1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These",...
PMC11739484	A uniform scratch was made in the monolayer using a 200 µL pipette tip.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "uniform", "scratch", "was", "made", "in", "the", "monolayer...
PMC11591052	ATF3 is considered a ‘’hub of the cellular adaptive-response network’’ , regulates serine biosynthesis by increasing PHGDH, PSAT1, and PSPH , and also coordinates serine and nucleotide metabolism .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10847511

These findings highlight the limitations of drug and biomarker discovery research based on existing cell line databases and emphasize the need for caution when interpreting results obtained from such sources.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9503685

Cells were cultured in Dulbecco’s Modified Eagle Medium (DMEM) supplemented with 10% Fetal Bovine Serum (FBS), 2 mM L-glutamine and 1% penicillin-streptomycin solution and incubated at 37 °C in a humidified atmosphere with 5% CO2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Mutations of TP53 in JAK2V617F patients are linked to AML transformation, illustrated by development of leukemias after retroviral overexpression of JAK2V617F in TP53 inactivated (KO) cells transplanted in irradiated animals, thus a possible cooperation between TP53 inactivation and JAK2 signaling in transformation pro...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11696576

LTB4 showed the greatest induction versus unstimulated control in this cell type with an 18-fold increase versus between a 4-to-6-fold increase for the other eicosanoids.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC3675084

Together, the results show that efflux transporter P-gp contributed to the selected paclitaxel resistance in SKOV-3-TR and OVCAR-3-TR cells, but BPR0L075 is not a substrate for efflux pumps, which contributes to its ability to overcome paclitaxel resistance. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "...

PMC11413393

c Western blot analysis of asymmetric dimethylarginine (aDMA) changes in 786-0 and RCC243 cells after MS023 treatment using the ASYM25 antibody for indicated period of time.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...

PMC11441402

One-way ANOVA analysis with Tukey’s multiple comparisons was used to compare GI50 and LC50 values calculated for each assay, where p < 0.05 was considered statistically significant.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7917457

OVs can induce tumor cell killing through direct lysis of infected tumor cells or through induction of a strong antiviral immune response, leading to the elimination of OV-infected cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Methods: This is a quantitative study; a cross-sectional survey was conducted among Tunisian youths (n = 182; male 23,3 %, female 76,7 %).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11742670

MAE comparison for testing and training datasets to predict IC50 on three different cell lines. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MAE", "comparison", "for", "testing", "and", "training...

PMC6364197

This could be attributed to the similar morphology of the PCL scaffolds to the bone marrow, as collagen type I helps in cell chemoresistance by activating DDR1 (36).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Summary/Conclusion: In our local DLBCL population treated with immunochemotherapy the COO according to the Hans algorithm, despite the small number, was suprinsingly found to be a significant independent prognostic factor.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11389534

Deeper exploration is necessary to unravel the exact molecular mechanisms that govern its diverse functions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Deeper", "exploration", "is", "necessary", "to", "unravel", ...

PMC11656048

CHX is a kind of inhibitor of protein synthesis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CHX", "is", "a", "kind", "of", "inhibitor", "of", "protein", "synthesis", "." ] } ]

PMC4485786

Besides its role in T-cell priming, IL-12 efficiently reverts T helper (TH)17 cells back into a TH1 phenotype, restores M1 macrophage function, and mediates dendritic cell (DC)-NK interactions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Mean fluorescence intensity (MFI) cutoffs (ECL: MFI=1.43; RCA: MFI=1.10) were calculated based on HCs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mean", "fluorescence", ...

PMC11301242

Annotation and (B) functional enrichment analysis of ecDNA amplicon peaks.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Annotation", "and", "(", "B", ")", "functional", "enrichment", "analysis", "of",...

PMC11721587

These observations suggest that the nuclear Ci-Sufu-Fu complex may contribute to Ci function.

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PMC11632064

We examined the data from this study to determine whether our candidate genes for the mitochondrial resistance signature were included.

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PMC11026382

Error bars in x indicate the standard deviation across N = 3 experimental replicates, error bars in y describe the standard deviation obtained by jackknife (leave-one-out) sub-sampling the data and refitting the model ten times (all points centered at the mean).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6889484

Viruses from peak production, normalized for p24 CA, from round 1 cultures 100% CEM (day 7; indicated by a blue star in A), 50%CEM:50%CEM/D128K (day 9; indicated by a red star in A), and 25% CEM:75% CEM/D128K (day 12; indicated by a green star in A) were used to infect either 100% CEM or 100% CEM/D128K cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11679033

Some authors did not find significant DNA damaging effect of CIT using comet assay.

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PMC8041314

However, the simultaneous targeting of ABCB1, ABCC1, and ABCG2 has only very recently been emphasized.

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PMC9429973

In patients with a partial response (PR) to treatment, the number of positive cells was statistically significantly higher than in patients with CR: 80% (58-88) vs. 24% (8-42), respectively, p<0.001.

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PMC9429973

Aims: The aim of this study was to use the combination of CRISPR/Cas9 screening and high-throughput drug screening on cells with introduced SF3B1 or NOTCH1 mutations in order to reveal unique vulnerabilities specific to the cells carrying these frequent CLL mutations.

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PMC11543935

The rapid evolution of medical technologies and devices, coupled with the growing shift towards alternatives to animal models, like the Directive 2010/63/EU of the European Parliament which was implemented as “an important step towards achieving the final goal of full replacement of procedures on live animals for scien...

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PMC10530622

In mice with obesity induced by leptin deficiency, Amin et al., 2018 observed hyperoxaluria compared to lean control animals.

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PMC9429973

When asked how much they were bothered by treatment side effects, a majority of patients reported “a little bit” or “not at all” at most cycles (71%-89% in the high-risk group and 46%-86% in the non–high-risk group).

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PMC6642070

p53 and β-enolase protein in A-204 cells exposed to atorvastatin (Atr), pitavastatin (Pit), simvastatin (Sim), rosuvastatin (Ros), and lovastatin (Lov) at 10 μM for 48 h. (g) p53 and β-enolase protein in A-204 cells after lentivirus-mediated knockdown of HMGCR. (

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PMC11594641

Ribonucleoprotein was added to the transfection reagent, previously diluted in Opti-MEM, and incubated for 5–10 min at room temperature.

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PMC8041314

Screening of a virtual compound library for novel broad-spectrum ABCB1, ABCC1, and ABCG2 inhibitors.

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PMC11049548

Analyzing metabolic profiles from ex vivo primary cell cultures post six cycles of platinum-based chemotherapy would be of high interest.

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PMC11247842

Putative causal genes were called as genes found by nearest gene or gene-analysis that are also supported by gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, or/and mammalian phenotype database (MPD).

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PMC10093184

As osteosarcomas represent a very heterogeneous malignancy and the number of available canine osteosarcoma cell lines is limited, their further de novo isolation and characterization are necessary to span the variability of the naturally occurring tumor.

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PMC11461833

In addition, we also overexpressed lamin A in HEK293 cells.

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PMC11746948

Furthermore, pharmacologically modulating GPX4 palmitoylation impacts liver ischemia–reperfusion injury.

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PMC6617630

a–c WT-MYC, SH, DHL, THL, and BCL-2/BCL-6 translocation harboring cell lines were treated with 3 different pharmacological BET bromodomain inhibitors I-BET (a), JQ1 (b), and OTX (c) for 72 h and cell survival was assessed by flow cytometry after annexin V/PI staining.

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PMC8916024

Differences in α-index among the three groups were assessed with the Kruskal–Wallis H test and Tukey HSD test.

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PMC11597167

The results are presented in Figure 1 and tabulated in Table 2.

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PMC10142392

Multiple branch compositions also exhibit low critical micelle concentrations, high loading capacity, and controlled release of the cargo.

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PMC11536589

Representative images were shown here and other images were represented in Supplementary Fig. 5A.

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PMC9429973

Findings derived from cytogenetics and molecular characterization in these patients are shown in Figure1.

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PMC10728200

However, Ferrostatin-1 itself did not affect ROS and lipid-ROS levels (Fig. S3 and 1D, E).

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PMC10956161

Immunohistochemistry was used to verify the levels of expression of PRDX6 protein in samples of lung adenocarcinoma compared with normal adjacent tissue.

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PMC10932641

PCNA, proliferating cell nuclear antigen; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; NC, negative control; lncRNA, long noncoding RNA; SI, silent; OE, overexpressive.

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PMC11352666

The hallmark of EWS is the EWS-FLI1 fusion protein, which acts as a transcription factor, driving aberrant gene expression.

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PMC11704834

Consistent with these results, TLE1 expression in A549 cells also conferred protection against the proliferation-inhibitory and apoptotic effects of the third generation EGFR-TKI osimertinib (Fig. S2A-D) and attenuated the antitumor effect of gefitinib in the EGFR-TKI sensitive, EGFR-mutant LUAD HCC827 cell line (Fig. ...

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PMC11694346

As depicted in Fig. 8(a), the untreated cells (control group) exhibited negligible fluorescence, indicating lower inherent autofluorescence.

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PMC9429973

One patient died of toxicity attributed to Gilteritinib (febrile neutropenia).

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PMC9429973

The heterogeneous nature of the disease requires more flexible, potent and safer approaches to make T-cell based treatments available for AML patients.

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PMC6901583

The abovementioned effects were assessed in the animal models as described in the materials section.

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PMC8753818

Statistical analyses of the data were done using GraphPad Prism 6.0, and the data were represented as mean ± S.E. Calculations of the level of significance (p) were done by Mann–Whitney U test, A p value less than 0.05 (p < 0.05) was considered statistically significant.

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PMC11746942

A Venn diagram showing overlap between upregulated ATAC-seq peaks in psoriasis patients and downregulated genes after TY treatment in HaCaT cells (10 μM TY and 25 μg/mL IL-6), including K16 and K17.

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PMC11271800

In addition, since patients with advanced disease need to be treated with long-term imatinib and multiline TKIs, their anti-tumor immunity is suppressed and weakened, and ICIs should be administered as early in the disease as possible.

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PMC11244823

As shown in Fig 5, the posC1 serum precipitated all four antigens at values of up to 10 RLU, whereas the ELISA-negative serum No 62 precipitated more than two logarithmic scales less.

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PMC11703992

By integrating transcriptomic and MR analyses, we provided in-depth insights into significant genes in CD4+ Memory T cells in GCA and identified causal effects between DDIT4/ARHGAP15 and the occurrence of GCA.

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PMC7887261

TRICL Transdisciplinary Research in Cancer of the Lung, CMC Combined Multivariate and Collapsing, KBAC Kernel-Based Adaptive Cluster, LoF loss of function, LC lung cancer, PF pulmonary function, OR odds ratio, CI confidence interval, o/e observed/expected. *

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PMC11593713

Abbreviations: HAdV5—human adenovirus 5; HcoV-229E—human coronavirus 229E; HcoV-OC43—human coronavirus OC43; HRV A—human rhinovirus A; IU—international activity unit.

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PMC6948907

Inhibition ratio of different concentrations was calculated.

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PMC11678448

Pasteurella is ubiquitous in animal populations and is generally considered a component of the commensal microbiota found in the oral cavity, nasopharynx, and respiratory tract .

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PMC11752767

Melanoma is among the most immunogenic malignancies expressing melanoma-differentiation antigens and neoantigens.

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PMC11774747

Furthermore, alternative systems, such as those based on CD20 mimotopes, have also been explored as potential elimination markers, offering additional safety mechanisms (119, 120).

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PMC11377827

pHRSIN-pSFFV-pPGK-Puro/Hygro USP43 expressing vector was transfected to 5 × 10 cells in six-well plates using Fugene.

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PMC9429973

Of ptn started on 1st line IM, NIL, and DAS; 94%, 63% and 100% received the licensed doses (400 mg OD, 300 mg BD, and 100 mg OD), respectively.

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PMC11719944

T cells play a central role in regulating and initiating these responses.

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PMC2193049

Therefore, the participation of two complementary and possibly overlapping proteolytic systems in antigen processing could be envisaged and would be compatible with our results obtained after treatment of melanoma cells with lactacystin.

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PMC11026382

For the TYMS R166Q background the overall proportion of significant epistatic mutations was larger: while only 41 mutations (1%) showed significant negative epistasis, 851 mutations (28%) showed significant positive epistasis.

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PMC9429973

Universidad Complutense; Service of Hematology, Hospital La Paz, Madrid, Spain; Division of Hematology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United States of America Background: Congenital dyserythropoietic anemia type III (CDA III) is one of the rarest types of CDA.

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PMC10854447

Physicochemical and pharmacokinetic properties (Lipinski parameters) of compounds 7h, 7i, 7j, 7k, and 7l.

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PMC9429973

The median time to relapse post-ASCT was 6 (2-17) months.

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PMC9429973

However, some donors had been found carrying malignant hematopathy-related mutation genes when they had a physical examination.

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PMC5839394

Findings from several studies reported that both the AgNPs and Ag released by AgNPs are involved in the mechanism of cytotoxicity in different ways: infact, AgNPs probably provide a perfect surface outside the mitochondria for the univalent reduction of oxygen to superoxide from electron through the electron transport ...

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PMC10994876

To explore this, we assessed the production capacity of the cells.

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PMC8316344

D TRIB2 regulated TFRC expression in a PSMB5-independent manner.

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PMC10243817

Recently, we have discovered that the expression of Mex3 RNA-binding family member B (MEX3B) was significantly elevated in nasal epithelial cells in CRS (5).

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PMC11739696

Level of ROS generation within untreated (control) and Co3O4NPs-treated (303.80 µg/ml) melanoma A-375 cells.

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PMC9436459

Among albanol B (46), sanggenon D (128), and sanggenon B (165), 46 exhibited the best anti-inflammatory activity, which inhibited expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and suppressed production of pro-inflammatory cytokines and mediators in LPS-induced RAW264.7 cells .

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PMC7433824

The incubator, in which the flasks were kept, had a humidified atmosphere of 5% CO2 at 37°C.

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PMC11723947

HLA-B7 WT or HP1γ-deficient human naive CD4 T cells were injected i.v.

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PMC9429973

However, the clinical significance of major DNA double strand break repair pathway Non-Homologous End Joining (NHEJ) in T cell acute lymphoblastic leukemia remains to be studied in detail.

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PMC9429973

By co-immunoprecipitation, proximity-ligation assay (C) and Nanoluciferase experiments, we demonstrated the interaction between PHBs and the members of the eIF4F complex.

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PMC10421378

Afterward, the microorganisms were transferred to a 15 mL Falcon conical tube containing 9 mL MRS broth and sealed with parafilm, and incubated for 24 h at 30 °C.

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PMC7823217

The accurate control over physicomechanical and biological characteristics of a bioprinted construct is possible using advanced 3D printing technologies.

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PMC11607638

After tagging with a fluorescent protein KillerRed, confocal imaging confirmed localization of SKR in the plasma membrane of SKR‐KillerRed‐CHO‐K1 cells (Figure 4J).

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PMC11301095

Rifampin, although used in almost all survivor cases, is prone to interactions in combination therapy, affecting efficacy .

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PMC11589157

In conclusion, we have successfully generated a haplotype-resolved chromosome-level genome for the critically endangered northern white-cheeked gibbon, using the third-generation sequencing technologies.

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PMC11298021

MTT assay on Jurkat cells showed that the viability of Jurkat cells was significantly reduced ‎after exposure to rapamycin in a dose- and time-dependent manner. (

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PMC9429973

Eight out of nine responses were seen after the first cycle.

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PMC9119314

Selectivity index with respect to Hep G cells.

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PMC11088135

We will perform these issues in the future.

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PMC9429973

Aims: The objective of this study is to better define the current survival landscape of CML and the long-term toxicities, so that we can have a better and updated understanding of the disease and the actual clinical practice in local, regional and global settings.

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PMC11285179

For RDH13 and DHRS11 gene silence, pericytes were infected with negative control siRNAs, RDH13-targeting, or DHRS11-targeting siRNAs (genepharma).

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PMC11413393

This deficit was comparable to that seen with the use of a DNA-dependent protein kinase (DNAPK) inhibitor, a well-characterized disruptor of DSB repair.

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PMC9545714

Tetrahydrofuran (THF) was purchased from Sigma Chemical Company (St. Louis MO).

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PMC9780037

In addition to PEGylation, ionic liquids have also been shown great value in extending cyt c thermal stability and shelf life.

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PMC9844987

prQTLs, dprQTLs, and frQTLs with FDR ≤5% were retained.

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PMC7812570

Compared to the infectivity of HIV-1 strains produced from cells cotransfected with an empty vector (negative control), the infectivity of both HIV-1 NL4-3 and THRO.c/2626 produced from cells expressing GPI-m36.4 but not GPI-FluIgG03 was dramatically decreased (Fig. 7C).

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PMC11352666

These data indicate that EWS cells can be particularly dependent on MCL-1 for survival, especially if they express high levels of EWS-FLI1.

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PMC11739484

A uniform scratch was made in the monolayer using a 200 µL pipette tip.

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PMC11591052

ATF3 is considered a ‘’hub of the cellular adaptive-response network’’ , regulates serine biosynthesis by increasing PHGDH, PSAT1, and PSPH , and also coordinates serine and nucleotide metabolism .

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