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PMC11680982
For HER2-low cells G1 phase: shNC vs. shHER2, P = 0.001. **
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PMC11363012
Elucidating both the biosynthesis and function of natural products would be greatly facilitated by tracking the location of these metabolites at the cell-level resolution.
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PMC11468365
This process results in a benchmark dataset comprising 17,901 unique drug combinations, involving 38 distinct drugs and 37 cancer cell lines.
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PMC11794568
Cells were inoculated into 24-well plates as previously described and cultured for 24 h before being assayed using the Edu Proliferation Kit (Beyotime Biotechnology, China).
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PMC6442998
The myoid phenotype of GIST48 cells echoes the presence of small cluster of cells expressing myoid markers in a subset of imatinib-responsive GIST tissues reported by Agaram et al. .
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PMC11538390
d Sequencing chromatograms of anti-IRF6 and anti-H3K27Ac ChIP-PCR products of cells heterozygous for rs570516915.
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PMC10142392
Furthermore, the hydrophilic model dye 5(6)-carboxyfluorescein encapsulated in an aqueous polymer matrix exhibited slow and sustained release at pH 7.4 but highly accelerated release below pH 7.4, indicating the desired pH sensitivity of the system in the endosomal pH range .
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PMC8592717
Several mechanisms may be relevant for bringing about the protective effects.
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PMC8097906
Cell viability measurement via MTS-assay after 48 h treatment with isolated pure VSM compounds ß-sitosterol and lupeol (50 μg/ml) of the RMA cell line: e RH-30, and f HA-OH1.
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PMC11711127
Further, owing to the immunological relevance of senescence in T cells, several ongoing studies aim to delay senescence by developing strategies to maintain telomere length and prolong telomerase activity in specific populations of T cells (199).
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PMC9895440
The advent of single-cell technologies has re-shaped our understanding of the tumor-infiltrating immune compartment including exhausted T cells in human patients.
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PMC11011837
This encourages a shift towards personalized therapy approaches grounded in metabolic classification to integrate the genetic approach.
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PMC11791478
Intact XB002 ADC concentrations (25A3 conjugated with at least one zovodotin molecule) were determined by a similar method, except that a biotinylated anti-zovodotin antibody was employed as the capture reagent.
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PMC11656380
Basic cell-penetrating peptides such as HIV-1 TAT and R8 interact with negatively charged heparan sulfate proteoglycans (HSPGs) for cellular entry.
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PMC9954564
However, no study has evaluated the role of LILRB1 and LILRB2 polymorphisms in developing vitiligo or the possible interactions between HLA-G and the genes encoding its receptors.
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PMC10854447
Inspection of the docked complexes revealed that the compounds bind tightly within the binding pocket.
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PMC11711127
It was seen that GRAIL expression was downregulated by specific siRNA and GRAIL overexpression was induced by pcDNA-GRAIL transfection.
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PMC7351993
A sample sorted with the RIACS was loaded into a custom glass bottom chamber with a volume of 1 mL and a viewing area of 7 mm in diameter fabricated by bonding a glass substrate (No.1 0.12–0.17 mm, 25 mm diameter, Matsunami) and a cylindrical structure made of PDMS (polydimethylsiloxane, Sylgard 184, Dow Corning), and ...
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PMC6024716
The OAZ1 knockout cell lines displayed up to four-fold higher expression of both stably and transiently expressed proteins, with comparable growth and metabolic activity to the parental cell line; and an approximately three-fold increase in intracellular polyamine content.
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PMC11615828
Additionally, the gene depletion of endogenous regulators or overexpression of dominant negative mutants is a common strategy to inhibit specific pathways.
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PMC10813895
TGFβR2i treatment enables cKit luminal epithelial cells progenitors, which are ER−, to differentiate into ER+ luminal epithelial cells and induces ELF5 expression in ER+ luminal epithelial cells, suggesting that ELF5-expressing progenitors, regardless of their ER status, can give rise to ER+ luminal epithelial cells.
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PMC9429973
Aims: To determine immune factors responsible for elimination or control over residual CML cells, which may be crucial for achieving long-term relapse-free survival (RFS) and TFR after imatinib discontinuation.
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PMC11453018
A Bar graphs show the dose-dependent inhibition of viability in ES cell lines (SKES1, A673, A4573, and TC71) compared to normal human myoblast cells (LHCN) following iP300w treatment for 48 hours.
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PMC11290772
To assess the time curve of ROBO1-NK cells lysing SKOV-3 cells, xCELLigence RTCA instrument (Agilent, USA) was utilized following the procedure outlined in the data sheet.
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PMC9429973
M. Jagurinoski, E. Aleksov, M. Stojcov-Jagurinoska, I. Tonev, R. Vladimirova, Y. Davidkova, G. Balatzenko, B. Spassov, M. Guenova Laboratory of Hematopathology & Immunology; Department of Clinical Hematology; Laboratory of Cytogenetics & Molecular Biology, Specialized Hospital for Active Therapy of Hematological Diseas...
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PMC11063646
To assess the spreadability of the formulated emulgels, a pulley equipped with the wooden block, a pair of mirror-image glass slides, and standard weights were used.
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PMC7369657
In order to confirm the inhibition of proliferation of 143B cells, a CCK-8 assay (Figure 1(c)), NR assay (Figure 1(d)), and an LDH leakage assay (Figure 1(e)) was performed.
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PMC11592837
Applying the AKLIDES platform and its integrated algorithms to differentiate between the foci-like and a diffuse overall nuclear staining of γH2AX in the course of cell death, we also found disparate results between PBMC and Jurkat cells.
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PMC11648299
The use of oral antibiotics due to secondary infections was frequent, and oral antivirals were prescribed to a patient with the diagnosis of eczema herpeticum (Fig. 1).
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PMC11351758
Although the existence of a transient or flicker opening of MPT has long been debated from different aspects, MPT pore flicker has recently been elegantly demonstrated using isolated mitochondria.
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PMC9429973
The extension to a larger number of patients will confirm the results obtained and detect variables that remain cryptic to the karyotype.
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PMC11718109
Scale bar, 10 μm.
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PMC10523483
Mean ± SD, data analyzed by t test. (
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PMC11530949
Treatment with the Ag-doped CuO NPs significantly increased ROS levels and NO enzyme activity, approximately 1.5 times and three times higher, respectively, than the levels observed with the plant extract.
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PMC11772585
C The mRNA levels of METTL1 in normal specimens and cSCC tumors were detected by qRT-PCR.
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PMC9429973
Image: Summary/Conclusion: Add-on parsaclisib showed efficacy in patients from both low and higher baseline PC groups.
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PMC11679326
Adenovirus-delivered UPL1 lectin affected multiple signaling cascades in hepatocellular carcinoma Huh7 and BEL-7404 cells .
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PMC7602170
In the non-SDH deficient GISTs, BRAF-mutated GISTs, NF1-related GISTs, K/N-RAS mutation-associated GISTs, and quadruple wt GISTs are included .
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PMC8010066
4The changes in virulence factor production in P.aeruginosa strains.
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PMC11172027
The cell growth of MTK-SK without the use of NALM or NASeLM showed a significant increase over time, as shown in Figure 4, from 100% up to 400%.
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PMC11055510
In particular, circMAN1A2 expression is significantly upregulated in the sera of OC patients and has a promising clinical application as a good diagnostic marker (Fan et al., 2019).
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PMC9424261
J Total ubiquitination of MDM2, as co-IP by anti-MDM2 antibody for the indicated treatment in Bel-7402 cells with or without HERPUD1 knocked out, and measured by anti-total ubiquitin antibody.
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PMC11766309
In summary, the results of the pan-cancer analysis provided new insight into the SNARE protein YKT6 as a target gene and candidate oncogene with actionable mutations.
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PMC9429973
Patients were aged 20 years or less.
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PMC11291490
CD4 T cells play a pivotal role in several crucial aspects of immune responses, including the generation of high-affinity neutralizing antibodies, immunoglobulin class switching, and the optimal expansion of CD8 cytotoxic T lymphocytes.
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PMC11653168
In Jurkat cells, a similar dose-dependent reduction in viability was observed; however, the inhibitory effect was less pronounced compared with in CCRF-CEM cells.
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PMC11011837
Regarding the study of lipids, statistical analyses were conducted at three different levels: lipid classes, lipid molecular species, and lipid building blocks.
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PMC11588008
Centrifuge at 12,000 rpm for 10 min.
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PMC9910796
Whole genome sequencing of vEP84Ri confirmed the absence of significant changes as compared to parental BA71V beyond the 2.7 kbp inducible cassette required for its construction.
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PMC11481779
We first train the encoder-decoder neural network and then use it as a component of the diffusion model - where we guide the diffusion using a latent representation of the sequence, as well as the final output from the encoder-decoder.
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PMC11066331
Finally, PLS-DA with 100 % accuracy (Cl = 96.5–100 %).
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PMC9429973
An average of 66ng of cfDNA and 660ng of gDNA from WBC were used.
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PMC9727330
In breast cancer cells, Asp can promote epithelial cell proliferation in the disturbance of exogenous glutamine supply (Zhang et al., 2014).
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PMC11468365
It used an autoencoder for each cell line feature (Gene expression, Copy Number Variation, Methylation, Global Chromatin Profiling, Metabolomics, microRNA, and Proteomics) to reduce the dimension of omics data.
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PMC11678368
It is worth mentioning that preliminary studies included similar calculations for the analogous cis isomers of the Pd(II) and Pt(II) complexes (cis-[PdCl2(4ClL)2] and cis-[MCl2(5ClL)2], where M = Pd(II) or Pt(II)), but these complexes turned out to be less stable than the trans isomers.
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PMC9429973
Funding: This study has been funded by ISCIII (PI16/01074 and PI19/00674) (co-funded by FEDER), Castilla y Leon (GRS 2058/A/19 and GRS 2331/A/21) and AECC (PROYE20047GUTI).
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PMC9429973
Inhibition of mTORC1 with Everolimus abrogated the toxic effect of Ven in the maternal cell lines (figure 1E), whereas TIC-10, an AKT/MEK inhibitor, partially restored Ven sensitivity in MAVER1-VR and MINO-VR cell lines (figure 1D).
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PMC11696659
Further, the observed effects of lung cancer on telomere length were comparable for both sexes.
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PMC11727145
Only Ono et al. used diluted exudates for keratinocyte culture, demonstrating a positive in vitro effect on cellular proliferation .
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PMC11085211
In particular, PBMCs and GIST-T1 were treated with the established four clusters at 30 µg/mL, while the 2A-20 subfraction, previously evaluated as inactive in GIST cells, was used as a negative control (Figure 9a).
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PMC9429973
In this setting, Fludarabine plus TBI is used for the PTCy arm.
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PMC11515150
Anti-CD5-D3 nanobody was screened by phage display technology, followed by constructing fourth-generation CAR plasmids ectopically producing IL-15 to generate CD5 CAR-NK cells derived from peripheral blood.
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PMC11531744
Subsequently, the risk curves were used to evaluate the prognostic models by setting the median risk score as the cut-off point (Figs. 3E and 3F).
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PMC11461874
The quantified band intensity of DBP relative to GFP was shown in the bottom.
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PMC11802929
The conceptual advance we report as APMAT lies in the combination of the large and comprehensive experimental data set and the biophysical analysis of the TCR-pMHC interface.
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PMC9429973
Of pts with ≥VGPR, 17 were minimal residual disease (MRD) negative, 10 in Cohort 1.
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PMC11683240
A–C, PT (10 ng/ml = 0.0000962 μM) and 20 μl of a fraction of the hemofiltrate library or the respective amount of solvent (H2O) were added directly to CHO-K1 cells in FCS-free medium and incubated for 4 h at 37 °C.
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PMC7802142
Data are expressed as mean ± SEM.
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PMC11787651
C, the number of peptides identified by each method with a retention time CV below 20% and below 5%, and the number of peptides with peptide ratio CV below 20% and below 5% across all control replicates.
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PMC11155445
Novel series of acyl thiourea derivatives (48–52) were synthesized and investigated for their antituberculosis activity against H37Rv, ATCC35822 (INH resistant), ATCC35838 (RIF resistant), ATCC35820 (STM resistant) and ATCC35837 (EMB resistant) standard bacteria strains.
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PMC11697703
Only basal dendritic arbors were used for Sholl analysis (gray for miR-Cnt and miR-Cnt-double, magenta for miR-365, red for miR-193b, and cyan for miR-193b-miR-365). (
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PMC11597291
Thus, the nCGO-PEG(10 kDa)/PCT particles were opted for further study compared to the nCGO-4 arm PEG(10 kDa)/PCT particles.
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PMC6487404
To evaluate the integrity of cellular monolayer, the transepithelial electrical resistance (TEER) was measured and transport studies were conducted when the TEER values were more than 300-400 Ωcm.
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PMC11144382
Cellular localisation of NFIX following immunofluorescence studies using an anti-Flag primary antibody and an Alexa Fluor 488 secondary antibody.
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PMC11574271
Fig. 1Anomalous RON expression correlates with heightened migration and matrix invasion of bladder cancer cells.
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PMC10998613
Altogether, we interpret these results as β2AR monomers associating with CXCR4 multimers in the cancer cell lines as illustrated in Fig. 4E.
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PMC9429973
Outcomes of ALL patients in our cohort are at odds with those reported from the developed world.
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PMC10578720
Briefly, HepG-2.2.15 cells were grown in DMEM (11965092, Gibco, NY) containing 10% fetal bovine serum without antibiotic-antimycotic supplementation.
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PMC11252553
At 72 hours post-irradiation, the percentages are reduced to 22.93%, 25.87%, and 27.31% for doses of 4, 8, and 12 Gy, respectively.
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PMC11095939
Promoter-specific primers used for these studies are listed in Appendix 1—key resources table.
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PMC11472569
Microvesicles, ranging from 150 to 1,000 nm in diameter, are shed directly from the plasma membrane.
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PMC11707577
Groups of 10 animals were placed into a plastic multiwell wrapped by foil to simulate dark conditions.
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PMC11082662
Transfection reagent Lipofectamine 3000 was mixed with both empty plasmids [short hairpin RNA (shRNA), Thermo Fisher Scientific] and the knockdown plasmids (sh-SMPDL3B#1, sh-SMPDL3B#2, sh-ACER2 + SMPDL3B; Thermo Fisher Scientific) to form cation complexes.
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PMC9250505
symbols above the bar of different groups represent the statistical significance compared to vehicle. *
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PMC10745221
However, no major differences were observed in ADMA or SDMA on histones between the 143B-P and 143B-R cells (Figs 4 and 5).
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PMC9429973
Immunoblotting was performed for β-catenin, PI3K-p110, phosphorylated AktSer and phosphorylated GSK3β Results: NUC-7738 reduced PI3K-p110, phosphorylated AktSer and phosphorylated GSK3β resulting in reduced β-catenin expression.
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PMC11486946
The examination by immunofluorescence microscopy of verteporfin supported EGFR internalization, as described later.
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PMC10748106
These observations revealed specific regions where the simple iridoids could interact with positively charged species at an energy level of −10 kcal/mol.
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PMC9429973
However, germline PAX5 mutations are extremely rare.
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PMC11507371
For once, the transmembrane diffusion of RONS is proposed to be easier in cancer cells due to an elevated expression of aquaporins, which facilitate transmembrane diffusion of H2O2 .
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PMC11576293
The antiproliferative activity of new compounds 9–29 was examined against four human cancer cell lines (colon - HT-29, pancreatic - Panc-1, lung - A-549, and breast - MCF-7) using Erlotinib as a reference.
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PMC10604092
We analyzed the clinical chemistry of each blood sample by centrifuging the sample at 1500× g for 15 min and collecting the resultant serum.
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PMC11678448
Infectious diseases can lead to various forms of immune dysregulation in both innate and adaptive immunity.
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PMC11612315
Heat hyperalgesia and mechanical allodynia induced by CFA were assessed via the Hargreaves test and the von Frey test, respectively.
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PMC11686380
GAP43 is one of ASD candidate genes, and mice lacking one allele for GAP43, GAP43 mice, exhibited some autistic-like behaviors.
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PMC7961460
All these features brought Gillingham and colleagues to name c10orf118 golgin104 in humans and flies .
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PMC11352666
Luminescence was measured using a plate reader.
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PMC11247842
Table 4Candidate causal mutations selected based on annotation of their potential effect on gene productsSNPAnalysis− log10(p)Rankinggene/biotypeEffect (SIFT score)6: 86,986,115MTAG_CM, MTAG_SCS21.02/17.9914/7Novel gene ENSBTAG00000049290Missense K15Q, deleterious (0)6: 87,324,678MTAG_CM, MTAG_SCS18.50/10.04318/496NPFF...
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PMC11377827
We did not observe a clear role for USP43 catalytic activity, but it is possible that USP43 may serve dual functions, in both helping maintain the nuclear pool of HIF-1α via 14-3-3 recruitment, alongside a potential catalytic role of USP43 on chromatin.
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PMC3019555
HIF-1α translation inhibition is reversed after microtubule repolymerization. (
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