Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC10154881
To analyze intracellular cytokines, cells were stimulated with 50 ng/mL PMA (Wako) and 500 ng/mL ionomycin (Wako) in the presence of brefeldin A (eBioscience) for 4 h, then stained with FVD506 followed by surface marker staining.
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PMC11755467
The reaction mix was incubated at 37 °C for 1 h. After checking the produced RNA on denaturing Polyacrylamid gel (15% Polyacrylamid, 7 M Urea, 1× TBE—15 min preheating, 30 min running the IVT product at 250 V), DNase I treatment was performed to remove the DNA template, followed by an RNA clean-up step for purification...
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PMC11519788
Similar results were observed in another UBC cell line, SW780 (Figure S2).
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PMC9429973
Pts with negative PET3 had an PFS of 89% and 80% for localizedand advanced stage, compared to 63% for all pts with positive PET3 (p <0.0001).
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PMC11741906
Moreover, miRNAs can regulate biological pathways that are involved in DNA damage signaling and response to cisplatin [, , , ].
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PMC11537649
Lnc NEAT1 was overexpressed in Hacat cells with miR-152-3p mimics or CDK6 knockdown.
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PMC10944868
The stability values exhibited by the tubulin-compound 12E complex may be attributed to the formation of tight interactions with various amino acids of the protein.
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PMC11587606
The mRNA expression levels of related genes in CRT0066854 treated MCF10A/RH for 3D cultures. (
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PMC11597167
Although rosmarinic acid possessed an IC50 value close to that of quercetin as the reference compound, its BACE1 inhibitory effect was weaker than quercetin.
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PMC8427838
E Western blot analysis of CRISPR-Cas9 mediated knockout of moesin in RKO cells and RKO cells expressing TMIGD1.
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PMC11756907
The cytotoxicity was assessed using the MTT cell viability assay.
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PMC9250505
Columns or points are the mean of triplicate experiments; bars, ±SEM. *
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PMC9429973
Summary/Conclusion: BCX9930 at doses up to 500 mg BID was generally well-tolerated.
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PMC9429973
Aims: The main objective is to evaluate the impact of lymphopenia in survival analyses of patients with severe and critical form of COVID-19.
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PMC6190245
They were cultured in a RPMI1640 containing 10% FBS and 1% streptomycin and penicillin.
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PMC11575040
BRAF oncogenes can drive and enhance the process of glycolysis.
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PMC8996378
Nevertheless, most of fourth-generation ABCB1 inhibitors have been evaluated in cancer cells in vitro, and their efficacy and safety in vivo have not been determined.
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PMC11173119
Moreover, it has been detected that FMF patients homozygous for M694V exhibit joint and skin-related issues, a higher rate of secondary amyloidosis, and higher colchicine dose requirements .
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PMC8494202
Gene Expression Profiling Interactive Analysis (GEPIA; http://gepia.cancer-pku.cn/) is a public data platform containing gene expression levels and patient characteristics for the vast majority of human tumors .
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PMC11765243
Thus, it is necessary to conditionally modify p110α PI3K expression to determine its function in T cells.
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PMC10568263
Its wide applications in superconductors, electrochromic systems, energy storage units, thermal materials, gas sensors, and immunosensors inspired this research to adopt it as the best candidate for biomarker detection and sensor construction.
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PMC8751435
Thus, the morphological manifestation of bubbling cell and ANXA5‐FITC‐ and PI‐stained cells were analyzed under fluorescence microscope (Leica, MDi).
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PMC9429973
Moreover, the combination of OICR-9429 and CX-4945 strongly induced ATAD2 downregulation compared with either single drug (P<0.001) (Figure 1H).
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PMC3995603
For sensitization, 50 mg Biostir-AD was topically applied on the upper dorsal skin and the back of the ears twice weekly for 4 weeks.
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PMC11683240
Cells were cultivated under humidified conditions at 37 °C with 5% CO2 and trypsinized and reseeded every two to three days for at most 25 times.
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PMC10723784
There were significantly (p < .001) less percentage of apoptotic cells in both carcinoma cells compared to non‐cancer ARPE19 cells, which also correlated with the selective cytotoxicity of CBD toward ovarian cancer cells (Figure 6).
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PMC11583690
A 25-cm x 4.6-mm column with a 5-μm particle size.
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PMC11655536
HD, healthy donor.
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PMC9429973
Clinical trial information: NCT05131022.
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PMC9429973
Image: Summary/Conclusion: 1L CT/CIT use is declining since 2014 and 1L targeted agent use is now the standard of care in real-world practice.
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PMC11741906
Clearly, these miRNAs have functions in cell death/survival related processes and treatment response.
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PMC11737091
Moreover, DBF4 expression was identified as an independent risk factor in multivariate Cox regression analysis.
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PMC11740399
PI3K: phosphatidylinositol 3-kinase; AKT: protein kinase B; mTOR: mammalian target of rapamycin; PKM2: pyruvate kinase M2; FASN: fatty acid synthase The anti-tumor activity of 3025@ML via lipid metabolism.
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PMC11023271
As such, the down-regulation of RIPK4 could be a consequence of wounding and/or tumorigenesis.
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PMC11394730
ROS accumulated in ginseng-treated colorectal cancer cells activated a cellular signaling defense system.
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PMC11742047
The lipidic fingerprint of K-562 cells treated and non-treated with CBD was obtained by performing an untargeted lipidomic study.
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PMC3995603
AC (10 mg/mouse/day) and Protopic ointment (50 mg/mouse/day) were topically applied on the back and ears once daily for 4 weeks.
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PMC11422497
The percentage of Ki67-positive cells in xenograft tumors was measured. (
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PMC11743316
Furthermore, the regulation of intracellular mitochondrial ROS signaling to efficiently prevent ROS-induced events that promote tumor growth and shift the equilibrium in favor of ROS-induced apoptotic signaling would present a challenge for innovative treatment approaches.
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PMC9221284
These three isoforms arise by alternative initiation of translation starting at three different in-frame codons: a non-canonical CUG for c-Myc1, an AUG located 15 codons downstream for c-Myc2 , and an AUG 100 codons further downstream for c-MycS .
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PMC10965315
Some of these compounds, such as mitomycin C and actinomycin D from bacteria, paclitaxel, etoposide, vincristine, and irinotecan from plants, have demonstrated notable antitumor activity on different cancer cells (Huang et al., 2021).
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PMC11703992
Subsequently, through Cellchat analysis, compared with the non-expression group, both the DDIT4+ and ARHGAP15 + group showed stronger communication intensity and increased interactions with other cell types, especially through CD40 Ligand (CD40LG) ligand-receptors (Fig. S5B).
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PMC11670954
When CECs were co-treated with 500 μM BA and 1 ng/mL TNFα, the co-treatment with BA had a protective effect on cell viability and cytotoxicity compared with 1 ng/mL TNFα alone.
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PMC10936243
The questionnaire was developed using the online software tool, JISC Online surveys.
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PMC8540611
Metal nanoparticles are the most studied objects for medicine, including their application as non-viral vectors.
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PMC11473750
Bottom Panel: Representative immunoblot analysis for SK-N-BE(2)-C cells either overexpressing for 48 h empty Vector (EV), Myc-tag-RNF121 full-length or each of the 4 Deletion Mutants of RNF121, probed with an anti-Myc-tag antibody. *
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PMC9429973
No patient progressed to AP/BC on or off study.
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PMC8735881
Emerging studies demonstrate that membrane-anchored HIV entry inhibitors, such as gp41-derived fusion inhibitory peptides and broadly neutralizing antibodies (bNAbs), are particularly effective for generating HIV-resistant cells.
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PMC10758402
Having established that intratumoral administration of DMF over gavage results in better survival rates in combination with i.t.
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PMC11562028
Increasingly more nanomedicines of CDs based on natural drugs are being developed, which have shown good application prospects in the treatment of cancer.
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PMC9454178
After transfection for 48 h, the knockdown efficiency was tested by western blotting.
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PMC10411253
Ultrasonography revealed small testes in the scrotum (Figure 1b).
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PMC9429973
Results: Although the aim of the study was to include 33 patients, recruitment stopped prematurely due to the difficulties for hospital visits posed during COVID-19 pandemic, and eventually only 10 patients were included.
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PMC9429973
Therefore, eliminating LSCs is an urgent, yet unmet, medical need.
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PMC11001582
Primers for human TGFB1 are: 5′-GGCTACCATGCCAACTTCT-3′ and 5′-CCGGGTTATGCTGGTTGT-3′. Primers for human COL6A1 are: 5′-ACTTCGTCGTCAAGGTCATC-3′ and 5′-CATCTGGCTGTGGCTGTA-3′. Primers for human GAPDH are: 5′-ACTAGGCGCTCACTGTTCT-3′ and 5′-CCAATACGACCAAATCCGTTG-3′. Drosophila were flash-frozen in liquid nitrogen.
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PMC5311252
The choice of time point was based on a previously published global analysis of miRNA effects at both protein and mRNA level.
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PMC9398137
Data from six in vivo experiments were analyzed, each experiment covering different time periods with different numbers of known data points.
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PMC11678368
The tests were performed after 72 h of incubation with the compounds in 96-well plates.
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PMC8041314
Compound characteristics such as lipophilicity or MW can inversely correlate with the inhibition of the respective transporter, therefore exacerbating the finding of a multitarget inhibitor.
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PMC4360730
Immortalized cell lines are annotated using EFO, as well as induced pluripotent stem cells and established stem cell lines (e.g. K562—EFO:0002067, induced pluripotent stem cell—EFO:0004905 and H1-hESC—EFO:0003042).
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PMC11635087
Considering the lack of intracellular organelles with chlorophyll in animal cells, electron microscopy images can be obtained efficiently if chlorophyll autofluorescence is used to detect cells with incorporated chloroplasts.
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PMC11723947
Source data are provided in the Source data file.
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PMC11769516
The study was conducted on Sprague-Dawley rats, which were given aflatoxin (25 ug/rat/day) and honey 1 mL/kg b.w.
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PMC11725127
Firstly, umbrella sampling was employed to make Cys284 solvent accessible.
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PMC11545868
The causes of cancer are varied and include genetic and environmental factors, as well as habits such as smoking, high fat intake, and UV radiation .
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PMC2777936
Real-time RT-PCR assays were used to independently determine the expression of a) FZD5, b) FZD7, c) WNT5A, and d) POU5F1 in NT2/D1, NT2/D1-R1, Tera-1, and 833K cells.
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PMC10882807
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer worldwide .
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PMC10719213
Primary antibody from Cell Signaling: CASPASE 3 (#9662).
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PMC9429973
Time to progression was about 14 months on average (range from 3 to 25 months).
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PMC11470999
Penfluridol (PF) directly binds to CIP2A in melanoma cells. (
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PMC11387401
In general, the clear majority of the identified RNA interactors of HIV-1 proteins are protein-coding mRNAs (86.1%), although nRIPseq using preconjugated MagStrep “type3” XT beads instead of anti-FLAG antibody appears to provide a broader overview of the non-coding binding partners.
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PMC4277423
Depending on coreceptor usage, HIV-1 variants are classified as being CCR5 (R5), CXCR4 (X4), or dual-tropic .
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PMC11723947
e, g, h Floating bar charts represent the mean of the biological replicates as well as the minimum and maximum values.
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PMC9780037
Its folding and heme attachment take place in the mitochondrial intermembrane space .
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PMC9429973
Overall, these data demonstrate mechanisms that enhance erythrophagocytosis in susceptible PNH patients by increased C3 loading on PNH-E and a decreased in removal of phagocytic opsonin, iC3b.
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PMC11621493
Lipid hydrolases are active in all body compartments, where they play essential roles in lipid degradation, transport, and remodeling.
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PMC11155445
These compounds also inhibited mycobacterial enzymes MtCA1, MtCA2 and MtCA3 with Ki values in the range of 95.2–6669.2, 3.4–57.1, and 446.6–9396.5 nM respectively, which revealed that the compounds had poor activity against MtCA3.
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PMC9429973
The model demonstrated 100% sensitivity and 90.48% specificity, with an accuracy rate of 94.29% and Area Under the Curve (AUC) of 0.99 (Figure 1B).
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PMC11367146
Molecular docking analysis showed daucosterol and gigantol to have good binding affinity with BCL2, ESR1 and MMP9, and the results were further confirmed through molecular dynamics simulation analysis.
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PMC10529414
Twenty-five micrograms of protein was separated via SDS–PAGE.
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PMC11486946
For each plate, we calculated the Z’-factor using the MSD ratios of the wells with the positive (10 µM gefitinib in DMSO) and negative (DMSO only) controls.
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PMC3765139
CD117 was expressed on virtually all HBL cells indicating that this might represent a specific feature of this highly differentiated cell line.
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PMC11092418
This was followed by the CDK1/2/5/9 inhibitor dinaciclib which inhibited the growth of all four cell lines with the IC50 values ≤ 0.16 µM. Of the other targeted agents, the Abelson murine leukemia viral oncogene homolog (Abl)/Src/c-Kit inhibitor dasatinib inhibited the growth of HBCCLs with IC50 values of 0.01 µM (U118...
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PMC11674834
Our findings showed 3,4-DMA induced lower ROS levels in CHO cells expressing NAT1*4 or NAT1*14B, suggesting that N-acetylation may serve as a protective mechanism against 3,4-DMA-induced oxidative stress.
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PMC11679033
In the second part, using Comet Assay and Cytokinesis Blocked Micronucleus Cytome Assay on the Human Peripheral Lymphocyte model, we further studied the genotoxicity of single compounds and their combination.
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PMC11531744
After addition with 3µg/mL carboplatin for 24 h, trypsin was used to digest OC cells which then washed with PBS for twice.
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PMC9429973
The induction therapy period was from first HMA initiation post-diagnosis (index date) to end of the cycle during which remission occurred.
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PMC11768927
A study by Ahmed et al. investigated the susceptibility of different prostate tumor cell lines to VSV.
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PMC6889484
Direct repeat deletion during transfection has been previously measured to be ∼5%.
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PMC11790599
Representative images are shown (n = 3).
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PMC11678841
The A-431 cell line from vaginal epithelial squamous cell carcinoma (ATCC CLR-1555) was cultured in Dulbecco’s Modified Eagle Medium (DMEM; Invitrogen, Carlsbad, CA, USA) supplemented with 1% penicillin/streptomycin solution (Euroclone, Milan, Italy) and 10% fetal bovine serum (FBS; Sigma-Aldrich, St. Louis, MO, USA).
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PMC11786704
E–G) Cell viability induced by H2O2 and capsules in RAW 264.7, DC2.4 and NIH3T3 cells. (
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PMC9429973
After a median follow-up of 16 months (range 1-50), 259 withdrew from therapy.
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PMC8097906
The positive control (10 nM Jaspl.)
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PMC9429973
The study is open at centers in the USA, UK, Japan, and Taiwan.
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PMC11040965
Values were normalized to β-actin and then to values for CD28-stimulated cells (dotted line).
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PMC11607321
While the overall reconstruction of the datasets was robust, there are examples where it could be improved, particularly for proteomics where intrinsic data sparseness makes it more challenging for the model to train successfully.
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PMC11143482
Interestingly, multiple lung metastases were detected in the lungs of mice injected with 3 × 10 of cancer cells as indicated in Fig. 7.
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PMC9219615
We initiated a high-throughput screening project of 2000 compounds from the ChemBridge DIVERset chemical library in search of novel cancer-killing compounds.
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PMC10975211
They offer potential advantages over conventional antibiotics, including fast action, reduced resistance buildup, and environmental friendliness.
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