OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11791478	inhibited tumor growth across multiple cancer models, including bladder, cervical, gastric, head and neck squamous cell carcinoma, and non–small cell lung cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10419319	Given that inhibiting glycolysis may disrupt the metabolic adaptations that enable cancer cells to survive and proliferate in the presence of cisplatin, identifying effective glycolysis inhibitors capable of sensitizing cisplatin-resistant OC cells to therapy holds significant therapeutic potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11462673	A IGV visual analysis highlights that the binding profile of LDB1 complex, along with T-ALL Hi-C data, was analyzed and reveal that there is binding at distal enhancers in the Myb-AHI1 intergenic region.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9351137	It is then possible to speculate that the CRS undergo relocation as subcomplexes by exploiting the interactions with microtubules and/or microtubule-associated proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", ...
PMC11473750	MYCN amplification correlates with poor prognosis in the childhood cancer, neuroblastoma, making MYCN an ideal target for therapeutic intervention.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MYCN", "amplification",...
PMC11314247	MCF-S7 and MDA-MB-231 cells were cultured using Dulbecco’s modified Eagle’s medium (DMEM) (Gibco Company, Waltham, MA, USA), a high-glucose medium without phenol red, containing 5% fetal bovine serum (FBS, Gibco Company, USA).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9250505	Cells were treated with the indicated concentration (Conc.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "treated", "with", "the", "indicated", "concentration", "(", "Conc", ".", ...
PMC6771295	The majority of the feedback loops originated from SIRT5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "majority", "of", "the", "feedback", "loops", "originated", "from", "SIRT5", "." ] } ]
PMC4360730	Annotating these metadata with ontologies provides alternate ways to search for these experiments (discussed below and Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Annotating", "these", "metad...
PMC11803149	n = 5 (mice transferred with young cells) and n = 3 (mice transferred with aged cells).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5", ...
PMC11564405	A The total anticancer immunity score in the low RILPL2 expression group and high RILPL2 expression group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "The", "total", "anticancer", "immunity", ...
PMC10936243	For example, respondents claimed to be worried about charging their client, lest they would be unable to afford to pay the bill.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11411004	HDACis are potent antiproliferative agents that regulate acetylation by targeting HDACs (Cao et al. 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HDACis", "are", "potent", "antiproliferative", "a...
PMC9429973	Secondary objectives include best response rates after infusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondary", "objectives", "include", "best", "response", "rates", "after", "infusion", "." ] } ]
PMC11766309	To further establish a link between YKT6 and mutations in CESC patients, the mutation profiles of patients with high/low YKT6 expression levels were assessed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	G3/4 neutropenia, thrombocytopenia, and anemia occurred in 9.8%, 19.5%, and 12.2% of pts, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G3/4", "neut...
PMC10671321	Briefly, hiPSC cells were dissociated with Stem Pro Accutase Cell Dissociation (Gibco, Waltham, MA, USA) and differentiated using the MyoCult-differentiation kit (Stemcell technologies, Vancouver, Canada).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700165	In SYF cells, ITK-SYK and BTK-SYK did not show any detectable phosphorylation, while TEL-SYK showed some phosphorylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "SYF", "cells", ",", "...
PMC10094712	The changes in [Ca]i were recorded using an Axiovert 200M inverted motorized fluorescence microscope (Carl Zeiss Microscopy GmbH, Jena, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11770130	Before the experiment started, the mice were housed in the CLAMS for 48 h. The data were processed as described before.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Before", "th...
PMC9429973	Frozen sera from patients and 14 healthy individuals (HI) were used for miRNA detection processed by Real–Time PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Frozen", "se...
PMC9429973	S. Tayabali, S. Moore, M. Jenner, F. Djebbari, L. Romao, L. English, R. Rodriguez, B. Briot Ribeyre, G. Roadknight, K. Varnai, S. Little, J. Davies, K. Woods, C. Davis, F. Borca, J. Olza Meneses, H. Phan, W. K. Wong, R. Popat University College London Hospitals NHS Foundation Trust, London; Oxford University Hospitals ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711063	In total, 536 genes were regulated by both ZG16B and Bex + Carv (Figure 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "total", ",", "536", "genes", ...
PMC9429973	The INPS-MD predicted ΔΔG mean in significant SNPs is -1.048kcal/mol (min -3.659-max 0.645), while in the non-significant group the mean was -0.376kcal/mol (min -3.361-max 1.617), t-Test p=1.61x10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11538390	Regions are labeled by their corresponding codes from Statistics Finland and shown in Supplementary Data 8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regions", "are", "labeled", "by", "their", "correspond...
PMC6650823	Structure-activity relationship studies were stablished, and a hit dipeptide emerged.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Structure-activity", "relationship", "studies", "were", "stablished", ",", "and", "a", "hit...
PMC9424261	P < 0.05 was regarded as statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", "was", "regarded", "as", "statistically", "significant", "." ] } ]
PMC11381192	A nomogram survival model incorporating CSI was built for precise risk stratification, and the nomogram demonstrated good performance in terms of discrimination, calibration, and clinical utility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11733919	TIS, therapy-induced senescence; 17D, 17-DMAG treatment; MNP@CD26, nanoplatform containing anti-CD26 antibody; MNP@CD26@17D, nanoplatform containing anti-CD26 antibody and 17-DMAG.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11397654	Further synthetic efforts are thus needed to obtain novel drug candidates constituted of functionalised calixarenes or calixarene analogues featuring suitable pharmacokinetic behaviours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "s...
PMC11509224	Membranoids B and D are considered to be artifacts and can be obtained by treating aplysulfurin with methanol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Membranoids", "B", "and", "D", "are", ...
PMC11610461	Gene set variation analysis suggested that PSENEN expression correlated positively with oxidative phosphorylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", "set", "variation", "analysis", "suggested", "that", "PSENEN", "expr...
PMC9429973	Results: Of the 454 pts, 223 had CEBPA and 231 monoallelic CEBPA mutations (CEBPA) affecting bZIP in 78 pts or TAD in 153 pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Within 18 m., 12 p. had perm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Within", "18", "m.", ",", "12", "p.", "had", "perm", "." ] } ]
PMC11321678	In addition, the genes also revealed the putative regulatory pathway and cellular origin, highlighting the critical role of cCREs for tumorigenesis and subgroup‐specificity determination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Prospective screening of asymptomatic children revealed that the VTE rate can reach as high as 32% post native Asparginase (NEA) treatment (Mitchell LG 2003).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	At an incubation temperature of 60 °C, the RCY was 66.0 ± 0.7% after 15 min of incubation and reached a maximum value of 71.7 ± 0.6% for this temperature regime when the reaction time was increased to 60 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11474209	Nek2, a cycle-reliant protein kinase, regulates mitotic progression and chromosomal segregation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nek2", ",", "a", "cycle-reliant", "protein", "kinase", ",", "regulates", ...
PMC11453018	This data was then processed using FlowJo software (Tree Star, USA) to quantify apoptotic events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "data", "was", "then", "process...
PMC11683240	From left to right, the number of the active chromatographic fraction used for each next fractionation step is given in chronological order.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", ...
PMC11787355	The harvested tumors were processed with tumor dissociation kit (#130-095-929, Miltenyi Biotec) and further enriched for tumor cells with tumor cell isolation kit (#130-108-339, Miltenyi Biotec) following the manufacture instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10237474	Both plates were transferred into the Octet.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "plates", "were", "transferred", "into", "the", "Octet", "." ] } ]
PMC11225860	This aggressive phenotype had an increased rate of replication and was seen in 2% of the treatment group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "aggressive", "phenotype", ...
PMC11380329	Fig. 5Venn diagram illustrating (A) The distribution of the number of specific and/or common metabolites in the different types of propolis analyzed, and (B) The different categories of specific metabolites identified by LC-MS/MS analysis in each type of propolis Venn diagram illustrating (A) The distribution of the nu...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10993311	T1 = ≤ 15 gestational weeks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "T1", "=", "≤", "15", "gestational", "weeks", "." ] } ]
PMC11541409	Ba/F3 or CHO cells with PDGFRA mutations (D842V, RD841-842KI) are resistant to imatinib, while CHO cells with PDGFRA mutation (D842Y, D846Y, Y849C, Del DIMH842-845, Del DIMH843-846, Del I843 and HDSN845-848P) are sensitive to imatinib (IC50 < 200 nM).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC9429973	However, most MM patients will relapse post-ASCT and many effective relapse regimens have a lenalidomide backbone (e.g. KRD: carfilzomib, lenalidomide, dexamethasone, DRD: daratumumab-RD, IRD: ixazomib-RD) making choice of regimen at first relapse increasingly difficult in patients progressing during LenM therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11204465	Compound 36 showed significant inhibitory effects on transplanted mouse leukaemia P-388 and L-1210 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "Compound", "36", "showed", "significant", "inhibitory", "e...
PMC8998437	By comparison, in LCL-2mon cells, the value was 0.111 ± 0.031 (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "comparison", ",", "in", "LCL-2mon"...
PMC10823017	We used ICA-1 (1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy) methyl] cyclopentyl]-, [1R-(1a, 2b, 3b, 4a)]), a selective PKC-ι inhibitor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747160	Q-Griffithsin is currently in clinical trials as a COVID-19 prophylactic, meaning that even if it does not have exceptional inhibitory capabilities against SARS-CoV-2, it still may be a pharmacologically favorable, non-immunogenic starting point for either a combinatorial prophylactic treatment or for the creation of a...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720107	Conversely, the Morado cultivar increased PPARγ protein expression by 1.3 ng/mL compared with the control (Figure 7D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "the", ...
PMC6442998	Upper panel: GIST48 were treated with imatinib (0 to 2.5μM), cilostazol (0 to 5μM) and combination of the two at a 1:2 ratio (i.e. imatinib 0.5μM + cilostazol 1μM) for 72h.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: The aim is to determine the origin of vacuoles Methods: Patients with SCD who benefit from an exchange transfusion program, have not only their own HbSS RBC but also transfused HbAA RBC in circulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659921	D2’.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "D2", "’", "." ] } ]
PMC11705862	Scale Bar = 20 μm To investigate the functional relevance of IRIS-1 and IRIS-2 in human neurons, we utilized the SH-SY5Y human neuroblastoma cell line model, a common choice for studying neuronal function and neurodegenerative disorders .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC9516447	Same as in (D) except eIF4E and phosphorylated eIF4E (p-eIF4E) protein levels were analyzed. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Same", "as", "in", "(", "D"...
PMC9429973	HCT-CI was not an indicator of late NRM (5-year NRM 10.2 % vs. 0%, p=0.29).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HCT-CI", "was", "not", "an", ...
PMC11413393	All animal studies were approved by the University Health Network Animal Care Committee under protocol #4896.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "animal", "studies", "were", "approved", ...
PMC11549612	Cellular component (CC) terms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cellular", "component", "(", "CC", ")", "terms", "." ] } ]
PMC3915447	The majority of chemotherapy medicines have serious adverse effects in addition to their clinical effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "majority", "of", "chemotherapy", "medicines", "have", ...
PMC11087055	The first distinction is the necessity of the Wnt/PCP pathway to the large-scale cell flow.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "first", "distinction", "is", "the", "necessity", "of...
PMC10812665	Glutamine may also be converted towards malate by glutaminolysis, i.e., by a sequence of reactions using only “the left part of the TCA”, not involving citrate synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10507284	Therefore, early diagnosis, exploration of prognostic biomarkers, and precise individualized treatment are of great significance in improving the clinical outcome of patients with STS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Sequence analyses proved the NUP98-NSD1 transcript, arising from fusion of NUP98 exon 12 with exon 6 in NSD1 gene, in all four patients (2M/2F; FAB M4/M5b; age 42, 54, 64 and 64 years).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9581083	S. baicalensis extracts have shown broad-spectrum antiviral activities against ZIKA, H1N1, HIV, and DENV viruses (Liu et al., 2021a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11775197	Wagner and colleagues verified the effect of PPARβ/δ on angiogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wagner", "and", "colleagues", "verified", "the", "effect", "of", "PPARβ/δ", "on", "angiogenesis"...
PMC9878562	The synergistic effect of LTB4 was impaired in the presence of the BIIL315 confirming the involvement of BLT1R ( Figure 6B ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "syner...
PMC11713679	The successful differentiation of the BE(2)‐M17 cells has been achieved and confirmed through morphological changes.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "successful", "differentiation", "of", "the", "BE(...
PMC8735881	After posttransfection 48 h, the virus-containing supernatants were harvested and centrifuged at 2,000 × g for 5 min, passed through 0.45 μm filter to remove cell debris, and then stored in aliquots in a −80°C freezer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9712534	Statistical values between DMSO and ICRF treatments are as follows; WT: p = 1.41E−14, H58Y: p = 0.043, T65I: p = 0.031, Y66F: p = 0.822.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	In support of this hypothesis, we report that copper chelation can facilitate copper transfer between neuroblastoma cells and neutrophils in vitro and enhance effector function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11082662	SMPDL3B may function downstream of ACER2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SMPDL3B", "may", "function", "downstream", "of", "ACER2", "." ] } ]
PMC11502962	GIST882 cells were cultured to 60% confluence and replaced with FBS-free medium.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GIST882", "cells", "were", "cultured", "to", "60", "%", "confluenc...
PMC10898159	ETV1, an ETS family transcription factor, is located on chromosome 7p21 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ETV1", ",", "an", "ETS", "family", "transcription", "factor", ",", "i...
PMC10125312	Results showed how exposure to low AuNR-PEG concentrations (≤2 nM) equivalent to less than 104 μg/mL of gold was not toxic to cells, whereas increases in concentration decreased the survival rate to less than 70% after 24 h of exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Selective blocking of RBCs particles and Hb endocytosis did not affect hemolysate-induced HUVECs activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Selective", "blocking", "of", "RBCs", "particles", "and", "Hb", ...
PMC9424261	These results demonstrate that CA increases the sensitivity of liver cancer cells to ferroptosis by upregulating HERPUD1, while HERPUD1 reduces the ubiquitination of MDM2 to reduce the content of GSS, thereby inhibiting GSH synthesis and promoting ferroptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	Furthermore, inhibition of EGFR revealed increases in CCL2, CCL5 and CXCL10 to a similar level as ALOX15B silencing (Fig. 4F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11724582	TGF-β1 successfully induced the differentiation of CAFs and upregulated the expression of CAF markers, including α-SMA and fibroblast activation protein (FAP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11464609	These findings may arise from index hopping, a phenomenon that standard analysis pipelines cannot detect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "may", "arise", "from", ...
PMC11672617	All cell types were cultured in a humidified atmosphere of 5% CO2 at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cell", "types", "were", "cultured", ...
PMC11766332	This molecule is subsequently transferred “en-bloc” to the nascent glycoprotein and then processed to form a vast array of N-glycan structures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC11661040	The results showed that the volume and weight of tumors in the CGREF1 knockout group were significantly lower than those in the control group (Fig. 7A-C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10123657	Ions with charge states ranging from 2+ to 5+ were fragmented, while the collision energy was adjusted between 23–65 ev as a function of the m/z value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	UV/VIS (CH2Cl2) λmax, nm (ε, M cm): 400 (123,300), 499 (10,100), 530 (5600), 618 (5200), and 674 (42,800).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6803987	IV.1 ~ IV.29.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "IV.1", "~", "IV.29", "." ] } ]
PMC11789597	Moreover, GSVA analysis revealed that a variety of cell processes or pathways were dysregulated by CAV1 knockdown (Figure S2B,C, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9341513	The gene body is shown as a solid tube, with flanking regions shown as an outline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gene", "body", "is", "shown", "as", ...
PMC11001582	After a further 5 d in culture without selection, individual colonies were isolated, expanded and screened for the desired targeting at both the 5′ end (5′-TCGGGGATTATGCCTGCTGC’3′ and 5′-GCATCCCAGGTCTCACTGCA-3′) and the 3′ end (5′-TCGAAAGGCCCGGAGATGAGGAAG-3′ and 5′-GGGTTCAGACAGGTACAGCAT-3′).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9622879	In this case, the local selling and buying prices in this time slot will be 36[12pt] $$&P_(t) = P_(t) $$(t)=Pmid(t)37[12pt] $$&P_(t) = (t) _^E_^(t) + P_(t) E_(t)}^E_^(t)}. $$(t)=PLS(t)∑i=1NEi,Comsell(t)+PMG(t)ECom(t)∑i=1NEi,Combuy(t).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8270637	The medium and H9 cells were replaced every 3 days.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "medium", "and", "H9", "cells", "were", "replaced", "every", "3", "days", "...
PMC11633763	Accordingly, identifying the precise molecular pathways underlying the aetiology of osteosarcoma and developing more potent therapeutic approaches are crucial.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accordingly", ",", "identify...
PMC11609529	Overall, these data demonstrate that the YM fusion is critical for sustaining cell growth and survival in YM-positive cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "t...
PMC11739504	To investigate the α-tubulin acetylation function of Kat2b in detail, an acetyltransferase domain-deleted construct of Kat2b (ΔAT), a nuclear localization signal domain-deleted Kat2b (ΔNLS) and both-domain-deleted Kat2b mutant (ΔATΔNLS) were created (Fig. 5a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Comparison of OS and PFS of different regimens pretended in figure 1,2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Comparison", "of", "OS", "and", "PFS", "of", "different", "regimens", "pretended...
PMC8409415	Tumor‐bearing mice were administered PBS or cisplatin (3 mg/kg) twice weekly (days 0, 4, 8, and 12) four times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11126803	All experiments were carried out with three replicates each time, and each experiment was repeated at least three times, independently.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "exper...
PMC9429973	Only 50% were receiving immunosuppressive treatment based on calcineurin inhibitors or corticosteroids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "50", "%", "were", "receiving", "immunosuppressive", "treatment", "b...
PMC11683240	Subsequently, the biotin-labeled Gαi was detected via Western Blot, while Hsp90 or Ponceau-S staining served as control for equal protein loading.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequ...

PMC11791478

inhibited tumor growth across multiple cancer models, including bladder, cervical, gastric, head and neck squamous cell carcinoma, and non–small cell lung cancers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10419319

Given that inhibiting glycolysis may disrupt the metabolic adaptations that enable cancer cells to survive and proliferate in the presence of cisplatin, identifying effective glycolysis inhibitors capable of sensitizing cisplatin-resistant OC cells to therapy holds significant therapeutic potential.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11462673

A IGV visual analysis highlights that the binding profile of LDB1 complex, along with T-ALL Hi-C data, was analyzed and reveal that there is binding at distal enhancers in the Myb-AHI1 intergenic region.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9351137

It is then possible to speculate that the CRS undergo relocation as subcomplexes by exploiting the interactions with microtubules and/or microtubule-associated proteins.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", ...

PMC11473750

MYCN amplification correlates with poor prognosis in the childhood cancer, neuroblastoma, making MYCN an ideal target for therapeutic intervention.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MYCN", "amplification",...

PMC11314247

MCF-S7 and MDA-MB-231 cells were cultured using Dulbecco’s modified Eagle’s medium (DMEM) (Gibco Company, Waltham, MA, USA), a high-glucose medium without phenol red, containing 5% fetal bovine serum (FBS, Gibco Company, USA).

[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...

PMC9250505

Cells were treated with the indicated concentration (Conc.,

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "treated", "with", "the", "indicated", "concentration", "(", "Conc", ".", ...

PMC6771295

The majority of the feedback loops originated from SIRT5.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "majority", "of", "the", "feedback", "loops", "originated", "from", "SIRT5", "." ] } ]

PMC4360730

Annotating these metadata with ontologies provides alternate ways to search for these experiments (discussed below and Figure 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Annotating", "these", "metad...

PMC11803149

n = 5 (mice transferred with young cells) and n = 3 (mice transferred with aged cells).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5", ...

PMC11564405

A The total anticancer immunity score in the low RILPL2 expression group and high RILPL2 expression group.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "The", "total", "anticancer", "immunity", ...

PMC10936243

For example, respondents claimed to be worried about charging their client, lest they would be unable to afford to pay the bill.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11411004

HDACis are potent antiproliferative agents that regulate acetylation by targeting HDACs (Cao et al. 2021).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HDACis", "are", "potent", "antiproliferative", "a...

PMC9429973

Secondary objectives include best response rates after infusion.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondary", "objectives", "include", "best", "response", "rates", "after", "infusion", "." ] } ]

PMC11766309

To further establish a link between YKT6 and mutations in CESC patients, the mutation profiles of patients with high/low YKT6 expression levels were assessed.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9429973

G3/4 neutropenia, thrombocytopenia, and anemia occurred in 9.8%, 19.5%, and 12.2% of pts, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G3/4", "neut...

PMC10671321

Briefly, hiPSC cells were dissociated with Stem Pro Accutase Cell Dissociation (Gibco, Waltham, MA, USA) and differentiated using the MyoCult-differentiation kit (Stemcell technologies, Vancouver, Canada).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11700165

In SYF cells, ITK-SYK and BTK-SYK did not show any detectable phosphorylation, while TEL-SYK showed some phosphorylation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "SYF", "cells", ",", "...

PMC10094712

The changes in [Ca]i were recorded using an Axiovert 200M inverted motorized fluorescence microscope (Carl Zeiss Microscopy GmbH, Jena, Germany).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11770130

Before the experiment started, the mice were housed in the CLAMS for 48 h. The data were processed as described before.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Before", "th...

PMC9429973

Frozen sera from patients and 14 healthy individuals (HI) were used for miRNA detection processed by Real–Time PCR.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Frozen", "se...

PMC9429973

S. Tayabali, S. Moore, M. Jenner, F. Djebbari, L. Romao, L. English, R. Rodriguez, B. Briot Ribeyre, G. Roadknight, K. Varnai, S. Little, J. Davies, K. Woods, C. Davis, F. Borca, J. Olza Meneses, H. Phan, W. K. Wong, R. Popat University College London Hospitals NHS Foundation Trust, London; Oxford University Hospitals ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11711063

In total, 536 genes were regulated by both ZG16B and Bex + Carv (Figure 3A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "total", ",", "536", "genes", ...

PMC9429973

The INPS-MD predicted ΔΔG mean in significant SNPs is -1.048kcal/mol (min -3.659-max 0.645), while in the non-significant group the mean was -0.376kcal/mol (min -3.361-max 1.617), t-Test p=1.61x10.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11538390

Regions are labeled by their corresponding codes from Statistics Finland and shown in Supplementary Data 8.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regions", "are", "labeled", "by", "their", "correspond...

PMC6650823

Structure-activity relationship studies were stablished, and a hit dipeptide emerged.

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PMC9424261

P < 0.05 was regarded as statistically significant.

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PMC11381192

A nomogram survival model incorporating CSI was built for precise risk stratification, and the nomogram demonstrated good performance in terms of discrimination, calibration, and clinical utility.

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PMC11733919

TIS, therapy-induced senescence; 17D, 17-DMAG treatment; MNP@CD26, nanoplatform containing anti-CD26 antibody; MNP@CD26@17D, nanoplatform containing anti-CD26 antibody and 17-DMAG.

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PMC11397654

Further synthetic efforts are thus needed to obtain novel drug candidates constituted of functionalised calixarenes or calixarene analogues featuring suitable pharmacokinetic behaviours.

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PMC11509224

Membranoids B and D are considered to be artifacts and can be obtained by treating aplysulfurin with methanol.

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PMC11610461

Gene set variation analysis suggested that PSENEN expression correlated positively with oxidative phosphorylation.

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PMC9429973

Results: Of the 454 pts, 223 had CEBPA and 231 monoallelic CEBPA mutations (CEBPA) affecting bZIP in 78 pts or TAD in 153 pts.

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PMC9429973

Within 18 m., 12 p. had perm.

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PMC11321678

In addition, the genes also revealed the putative regulatory pathway and cellular origin, highlighting the critical role of cCREs for tumorigenesis and subgroup‐specificity determination.

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PMC9429973

Prospective screening of asymptomatic children revealed that the VTE rate can reach as high as 32% post native Asparginase (NEA) treatment (Mitchell LG 2003).

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PMC11721277

At an incubation temperature of 60 °C, the RCY was 66.0 ± 0.7% after 15 min of incubation and reached a maximum value of 71.7 ± 0.6% for this temperature regime when the reaction time was increased to 60 min.

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PMC11474209

Nek2, a cycle-reliant protein kinase, regulates mitotic progression and chromosomal segregation.

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PMC11453018

This data was then processed using FlowJo software (Tree Star, USA) to quantify apoptotic events.

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PMC11683240

From left to right, the number of the active chromatographic fraction used for each next fractionation step is given in chronological order.

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PMC11787355

The harvested tumors were processed with tumor dissociation kit (#130-095-929, Miltenyi Biotec) and further enriched for tumor cells with tumor cell isolation kit (#130-108-339, Miltenyi Biotec) following the manufacture instructions.

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PMC10237474

Both plates were transferred into the Octet.

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PMC11225860

This aggressive phenotype had an increased rate of replication and was seen in 2% of the treatment group.

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PMC11380329

Fig. 5Venn diagram illustrating (A) The distribution of the number of specific and/or common metabolites in the different types of propolis analyzed, and (B) The different categories of specific metabolites identified by LC-MS/MS analysis in each type of propolis Venn diagram illustrating (A) The distribution of the nu...

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PMC10993311

T1 = ≤ 15 gestational weeks.

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PMC11541409

Ba/F3 or CHO cells with PDGFRA mutations (D842V, RD841-842KI) are resistant to imatinib, while CHO cells with PDGFRA mutation (D842Y, D846Y, Y849C, Del DIMH842-845, Del DIMH843-846, Del I843 and HDSN845-848P) are sensitive to imatinib (IC50 < 200 nM).

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PMC9429973

However, most MM patients will relapse post-ASCT and many effective relapse regimens have a lenalidomide backbone (e.g. KRD: carfilzomib, lenalidomide, dexamethasone, DRD: daratumumab-RD, IRD: ixazomib-RD) making choice of regimen at first relapse increasingly difficult in patients progressing during LenM therapy.

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PMC11204465

Compound 36 showed significant inhibitory effects on transplanted mouse leukaemia P-388 and L-1210 cells .

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PMC8998437

By comparison, in LCL-2mon cells, the value was 0.111 ± 0.031 (Figure 1A).

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PMC10823017

We used ICA-1 (1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy) methyl] cyclopentyl]-, [1R-(1a, 2b, 3b, 4a)]), a selective PKC-ι inhibitor.

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PMC10747160

Q-Griffithsin is currently in clinical trials as a COVID-19 prophylactic, meaning that even if it does not have exceptional inhibitory capabilities against SARS-CoV-2, it still may be a pharmacologically favorable, non-immunogenic starting point for either a combinatorial prophylactic treatment or for the creation of a...

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PMC11720107

Conversely, the Morado cultivar increased PPARγ protein expression by 1.3 ng/mL compared with the control (Figure 7D).

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PMC6442998

Upper panel: GIST48 were treated with imatinib (0 to 2.5μM), cilostazol (0 to 5μM) and combination of the two at a 1:2 ratio (i.e. imatinib 0.5μM + cilostazol 1μM) for 72h.

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PMC9429973

Aims: The aim is to determine the origin of vacuoles Methods: Patients with SCD who benefit from an exchange transfusion program, have not only their own HbSS RBC but also transfused HbAA RBC in circulation.

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PMC11659921

D2’.

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PMC11705862

Scale Bar = 20 μm To investigate the functional relevance of IRIS-1 and IRIS-2 in human neurons, we utilized the SH-SY5Y human neuroblastoma cell line model, a common choice for studying neuronal function and neurodegenerative disorders .

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PMC9516447

Same as in (D) except eIF4E and phosphorylated eIF4E (p-eIF4E) protein levels were analyzed. (

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PMC9429973

HCT-CI was not an indicator of late NRM (5-year NRM 10.2 % vs. 0%, p=0.29).

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PMC11413393

All animal studies were approved by the University Health Network Animal Care Committee under protocol #4896.

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PMC11549612

Cellular component (CC) terms.

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PMC3915447

The majority of chemotherapy medicines have serious adverse effects in addition to their clinical effects.

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PMC11087055

The first distinction is the necessity of the Wnt/PCP pathway to the large-scale cell flow.

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PMC10812665

Glutamine may also be converted towards malate by glutaminolysis, i.e., by a sequence of reactions using only “the left part of the TCA”, not involving citrate synthesis.

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PMC10507284

Therefore, early diagnosis, exploration of prognostic biomarkers, and precise individualized treatment are of great significance in improving the clinical outcome of patients with STS.

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PMC9429973

Sequence analyses proved the NUP98-NSD1 transcript, arising from fusion of NUP98 exon 12 with exon 6 in NSD1 gene, in all four patients (2M/2F; FAB M4/M5b; age 42, 54, 64 and 64 years).

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PMC9581083

S. baicalensis extracts have shown broad-spectrum antiviral activities against ZIKA, H1N1, HIV, and DENV viruses (Liu et al., 2021a).

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PMC11775197

Wagner and colleagues verified the effect of PPARβ/δ on angiogenesis.

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PMC9878562

The synergistic effect of LTB4 was impaired in the presence of the BIIL315 confirming the involvement of BLT1R ( Figure 6B ).

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PMC11713679

The successful differentiation of the BE(2)‐M17 cells has been achieved and confirmed through morphological changes.

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PMC8735881

After posttransfection 48 h, the virus-containing supernatants were harvested and centrifuged at 2,000 × g for 5 min, passed through 0.45 μm filter to remove cell debris, and then stored in aliquots in a −80°C freezer.

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PMC9712534

Statistical values between DMSO and ICRF treatments are as follows; WT: p = 1.41E−14, H58Y: p = 0.043, T65I: p = 0.031, Y66F: p = 0.822.

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PMC11638255

In support of this hypothesis, we report that copper chelation can facilitate copper transfer between neuroblastoma cells and neutrophils in vitro and enhance effector function.

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PMC11082662

SMPDL3B may function downstream of ACER2.

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PMC11502962

GIST882 cells were cultured to 60% confluence and replaced with FBS-free medium.

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PMC10898159

ETV1, an ETS family transcription factor, is located on chromosome 7p21 .

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PMC10125312

Results showed how exposure to low AuNR-PEG concentrations (≤2 nM) equivalent to less than 104 μg/mL of gold was not toxic to cells, whereas increases in concentration decreased the survival rate to less than 70% after 24 h of exposure.

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PMC9429973

Selective blocking of RBCs particles and Hb endocytosis did not affect hemolysate-induced HUVECs activation.

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PMC9424261

These results demonstrate that CA increases the sensitivity of liver cancer cells to ferroptosis by upregulating HERPUD1, while HERPUD1 reduces the ubiquitination of MDM2 to reduce the content of GSS, thereby inhibiting GSH synthesis and promoting ferroptosis.

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PMC11754432

Furthermore, inhibition of EGFR revealed increases in CCL2, CCL5 and CXCL10 to a similar level as ALOX15B silencing (Fig. 4F).

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PMC11724582

TGF-β1 successfully induced the differentiation of CAFs and upregulated the expression of CAF markers, including α-SMA and fibroblast activation protein (FAP).

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PMC11464609

These findings may arise from index hopping, a phenomenon that standard analysis pipelines cannot detect.

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PMC11672617

All cell types were cultured in a humidified atmosphere of 5% CO2 at 37 °C.

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PMC11766332

This molecule is subsequently transferred “en-bloc” to the nascent glycoprotein and then processed to form a vast array of N-glycan structures.

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PMC11661040

The results showed that the volume and weight of tumors in the CGREF1 knockout group were significantly lower than those in the control group (Fig. 7A-C).

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PMC10123657

Ions with charge states ranging from 2+ to 5+ were fragmented, while the collision energy was adjusted between 23–65 ev as a function of the m/z value.

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PMC11721277

UV/VIS (CH2Cl2) λmax, nm (ε, M cm): 400 (123,300), 499 (10,100), 530 (5600), 618 (5200), and 674 (42,800).

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PMC6803987

IV.1 ~ IV.29.

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PMC11789597

Moreover, GSVA analysis revealed that a variety of cell processes or pathways were dysregulated by CAV1 knockdown (Figure S2B,C, Supporting Information).

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PMC9341513

The gene body is shown as a solid tube, with flanking regions shown as an outline.

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PMC11001582

After a further 5 d in culture without selection, individual colonies were isolated, expanded and screened for the desired targeting at both the 5′ end (5′-TCGGGGATTATGCCTGCTGC’3′ and 5′-GCATCCCAGGTCTCACTGCA-3′) and the 3′ end (5′-TCGAAAGGCCCGGAGATGAGGAAG-3′ and 5′-GGGTTCAGACAGGTACAGCAT-3′).

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PMC9622879

In this case, the local selling and buying prices in this time slot will be 36[12pt] $$&P_(t) = P_(t) $$(t)=Pmid(t)37[12pt] $$&P_(t) = (t) _^E_^(t) + P_(t) E_(t)}^E_^(t)}. $$(t)=PLS(t)∑i=1NEi,Comsell(t)+PMG(t)ECom(t)∑i=1NEi,Combuy(t).

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PMC8270637

The medium and H9 cells were replaced every 3 days.

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PMC11633763

Accordingly, identifying the precise molecular pathways underlying the aetiology of osteosarcoma and developing more potent therapeutic approaches are crucial.

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PMC11609529

Overall, these data demonstrate that the YM fusion is critical for sustaining cell growth and survival in YM-positive cancer cells.

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PMC11739504

To investigate the α-tubulin acetylation function of Kat2b in detail, an acetyltransferase domain-deleted construct of Kat2b (ΔAT), a nuclear localization signal domain-deleted Kat2b (ΔNLS) and both-domain-deleted Kat2b mutant (ΔATΔNLS) were created (Fig. 5a).

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PMC9429973

Comparison of OS and PFS of different regimens pretended in figure 1,2.

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PMC8409415

Tumor‐bearing mice were administered PBS or cisplatin (3 mg/kg) twice weekly (days 0, 4, 8, and 12) four times.

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PMC11126803

All experiments were carried out with three replicates each time, and each experiment was repeated at least three times, independently.

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PMC9429973

Only 50% were receiving immunosuppressive treatment based on calcineurin inhibitors or corticosteroids.

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PMC11683240

Subsequently, the biotin-labeled Gαi was detected via Western Blot, while Hsp90 or Ponceau-S staining served as control for equal protein loading.

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