OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	The most frequent treatment-emergent adverse events (TEAE) were neutropenia (51%), fatigue (39%), and CRS (38%), with grade 3 CRS in 1 patient (2%) and no grade 4/5 CRS events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461874	Statistical significance was determined for genotype, time and interaction by two-way ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "was", "determined", "for", "genotype", ",", ...
PMC10988808	I Quantitative analysis of CCDC25.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "I", "Quantitative", "analysis", "of", "CCDC25", "." ] } ]
PMC9611901	It is clear to us that prohibited substances may no longer be used in processing of leather, but for the purpose of experiments it is allowed to compare the effects of prohibited substances with those whose use is permitted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4355729	The decrease of CTNNB1 protein was also observed in 786-mut1 shCTNNB1 and A-704-mut2 shCTNNB1 cells (P < 0.01; P < 0.01) (Fig. 6a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11381192	All cells were cultured in RPMI‐1640 medium (Gibco, USA) supplemented with 10% foetal bovine serum (Biological Industries, Israel) and 1% penicillin–streptomycin (Beyotime Biotechnology, Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10203589	In addition, blocking Wnt pathway significantly decreased the mRNA and protein expression levels of FGF18 and affected the colony formation of CD44-LT97 cells (68).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794847	Additionally, while we did observe a relationship between HVEM and GPT2, further studies are needed to decipher the intricate molecular mechanisms at play.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11451940	Both assays were carried out in accordance with the manufacturers' protocols, with a modification in the caspase induction assay: we used the CellEvent™ Caspase-3/7 green detection reagent only for detecting caspase-3/7 activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525028	Views of ac4C modification peaks of ATF4 in the 143B cell line from acRIP-seq. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Views", "of", "ac4C", "modification", "peaks", "of", ...
PMC9019892	β‐actin antibody was purchased from TransGen Biotech (Beijing, China; no. HC201‐02).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β‐actin", "antibody", "was", "purchased", "from", "TransGen", ...
PMC10870498	The primers used in cell transfection were synthesized by Sangon and listed in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primers", "used", "in", "cell", "transfection", "wer...
PMC11247842	Annotation file: the regulator elements and CpG islands annotation file were reformatted for GARFIELD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Annotation", "file", ":", "the", "regulator", "elements", "...
PMC6892818	Therefore, mCD40L regulates early signalling events in renal cells and, more importantly, TRAF2 and TRAF3 regulation is fundamentally different between normal and malignant cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11279397	Additionally, germacron dose-dependently inhibited Pseudo rabies virus (PRV) replication in vitro and displayed antiviral activity against PRV during the initial phases of viral replication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10745221	Recent studies have pointed to the role of S-adenosylmethionine-dependent protein arginine methyltransferases (PRMTs) in cell proliferation and cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", ...
PMC8540611	In experiments to determine cell death after 2 days of incubation, the uptake level did not drop so much, but remained at 30% for CEM-SS cells and 15% for HL-60 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	IBER is being investigated for the treatment of relapsed/refractory MM (RRMM) in a phase 1/2 study (NCT02773030).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IBER", "is", "bei...
PMC10165258	Schematic of the consecutive steps toward addition of multiple secondary droplets to primary droplets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematic", "of", "the", "consecutive", "steps", "toward", "addition",...
PMC11658074	4Surface protein sequences and EV subpopulations of AT-EVs and ADSC-EVs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4Surface", "protein", "sequences", "and", "EV", "subpopulations", "of", "AT-EVs", "and", "ADSC-E...
PMC10669128	Through this model, they reproduced gastrointestinal pathology in mice with remarkable penetrance, demonstrating that the constitutive activation of KIT signaling is pivotal and sufficient to cause neoplastic growth in mice .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Cytotoxic capacity, T cell proliferation and cytokine secretion were assessed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytotoxic", "capacity", ",", "T", "cell", "proliferation", "and", "cytokine", "secretion", ...
PMC7887261	In the seven validation datasets, of the 25 candidates, 100% were covered by the gnomAD, 22 (88%) in TCGA, 16 (64%) in COPDGene, nine (36%) in GELCC, and nine (36%) were covered in one of the three case–control studies (OncoArray, Affymetrix, and UKB) with genotyping data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9592219	We assessed the progress of wound healing and compared the results with the initial measurements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "assessed", "the", "progress", "of", "wound", "healing...
PMC11271278	To determine what types of enhancers are interacting with HAPI genes, the trans and long-range cis interaction data sets with enhancer contact values and interaction intensity calculated for each gene as described above are used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In this group, 88% of pts died in the short term without achieving remission, the remaining 12% of pts had short-term remission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7185206	Karpas-299 cells were treated with vehicle control versus TAPI-2, recombinant human ADAM10, or recombinant human ADAM17 over 24 h and PD-L1 positive cells were measured by flow cytometry.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770130	Ribosome pulldown was conducted as previously described, with modifications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ribosome", "pulldown", "was", "conducted", "as", "previously", "described", ",", "with", "modifi...
PMC9429973	AEs leading to discontinuation were reported in 2 new pts since the previous data cutoff; both pts discontinued and died due to COVID-19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11422150	Additionally, flow cytometry of bone marrow revealed suppressed production of M-MDSCs (Figure 6B), and production of M1 macrophages was also inhibited by hAMSC treatment (Figure 6C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257988	Drugs targeting MEK downstream in the MAPK cascade via inhibition of signal transduction pathways are less effective in treating KRAS-mutant NSCLC in multiple experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC4485786	In sharp contrast, up to 70% of the sarcoma cells from mice treated with either NHS-IL12/IL-2MAB602 or NHS-IL12/FcIL-7 expressed the senescence marker p-HP1γ or p16 (Fig. 5A, B), in the absence of PCNA (PCNA/p-HP1γ) (Fig. 5A, upper line inserts) and Ki67 (Ki67/p16) (Fig. 5A, lower line inserts).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11297139	p < 0.001.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.001", "." ] } ]
PMC11721587	To evaluate the dynamics Hh-induced Fu condensates, Cl8 cells were transfected with mEGFP-Fu and treated with Hh-conditioned medium for 16 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", ...
PMC11765243	As we see below, altered Treg differentiation was consistently observed in distinct conditions in p110αKD-T mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "we", "see", "below", ",", "altered", ...
PMC11635519	We designed a structure that encodes a fusion protein to display the MCP1 peptide on the cell surface.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "designed", "a", "structure", "th...
PMC10547921	The carboxylic acid-containing thailanstatin semi-synthetic analog 87 was directly coupled to trastuzumab surface lysine to obtain a very effective thailanstatin ADC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "carboxylic", ...
PMC11632064	Interestingly, the pro-inflammatory effects of BRD7389 could not be observed in A-375 above 300 nM due to cell death (Fig 1H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC5672695	The glutathione-S-transferase T1 (GSTT1) and glutathione-S-transferase M1 (GSTM1) polymorphisms were examined using the polymerase chain reaction method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "glutathione-S-tr...
PMC9429973	Understanding the needs of these patients will enable healthcare providers to properly support them.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Understanding", "the", "needs", "of", "these", "patients", "will", ...
PMC11337594	Ileitis in mice with FADD-deficient intestinal epithelial cells can be driven by necroptosis or GSDMD-dependent pyroptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ileitis", "in", "mice", "with", "FADD-deficient", "int...
PMC11746942	Moreover, the deletion of Stat3 in keratinocytes but not in T cells reduced psoriasis-like dermatitis, indicating that persistent STAT3 activation in keratinocytes leads to the pathogenesis of psoriasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11391695	In 96-well plates, HCC cells were seeded at a density of 3000 cells per well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "96-well", "plates", ",", "HCC", "cells", "...
PMC11772585	K The mobility and invasiveness were assessed by trans-well migration assay and matrigel invasiveness measurement (n = 5), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "K", "The", ...
PMC11697703	We first confirmed the specificity of the miR-193b∼365 cluster to corticospinal projection neurons in independent samples of purified corticospinal and callosal projection neurons on postnatal day (P) 2, and compared the relative quantity (RQ) of miRNA in corticospinal relative to callosal projection neurons via qPCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11343332	Target gene expression is normalized to GAPDH mRNA expression, and the results are expressed as a fold change from the control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Target", "ge...
PMC10454535	Treatments for MM include proteasome inhibitors, immunomodulators, monoclonal antibodies, corticosteroids, histone deacetylase inhibitors, and radiation therapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatments", "for", ...
PMC10568263	The Au@MnO2 precipitates were dried in an oven at 60 °C for 12 h. Finally, the Au@MnO2 precipitates were added to the DI water to obtain 3/10 by weight aqueous solutions of Au@MnO2 for further use.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6468656	Ghrelin, a peptide hormone, has been reported to promote cancer metastasis and is clinically associated with poor survival in various types of cancers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11252553	Radiation has a range of biological effects on cells, and one of the most significant outcomes is cell death, resulting in the loss of reproductive ability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	A total of 647 proteins were identified as putative Mecp2 interactors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "647", "proteins", "were", "identified", "as", "putative", "Mecp2"...
PMC10154097	This assay was performed to separate cell nuclear and cytoplasmic fractions according to previously described procedures using PARIS™ Kit (Ambion, Austin, TX, USA) followed by measuring circSOX4 level by qRT-PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	RVU120 is administered orally, each other day for 7 total doses per 21 days cycle, until disease progression/unacceptable toxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RVU120", "is", "a...
PMC11495567	Image Lab Software was used to quantify the chemiluminescence images that were then normalized against GAPDH and the controls and then plotted against the PCAIs concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Twelve pts (6.2%) switched to other BTKis and 5 pts (2.6%) did so for HTN.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twelve", "pts", "...
PMC8633974	To conclude, the combination of “diverse” strain-inactivating TatD and “tri-exon”-directed TatE gRNAs prompted maximal suppression of HIV-1 replication by CRISPR-Cas9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10530622	However, glycine’s contribution to oxalate production is very small .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "glycine", "’s", "contribution", "to", "oxalate", "production", "is", ...
PMC11731161	D Cell apoptosis rates of different MM cell lines after treated with indicated concentrations of SEL for 48 h. E Representative immunoblotting images and quantitative analysis of XPO1 protein levels in different MM cell lines treated with increasing concentrations of SEL for 24 h. F and G Immunofluorescent staining of ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637276	MDA-MB-231 cells were transfected with an siRNA targeting α2 integrin (siITGA2) or non-targeting siRNA control (siNT) and spheroids were embedded in 2 mg/ml collagen I and matrigel (1:1 ratio) matrix for 3 days.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10605143	We found that an increase in its expression may affect the intrinsic ability of human mammary epithelial cells to acquire mesenchymal characteristics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O" ], "...
PMC4112127	Further studies are now indicated in biospecimens of patients at high risk for CC, such as those with PSC, to assess the value of BMP3 and other methylation markers for screening or early detection of CC in biospecimens such as bile, bile duct brushings, blood or stool.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2614416	With BLASTP 2.2.15 [Oct-15-2006], mapping now includes RefSeq.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "BLASTP", "2.2.15", "[", "Oct-15", "-", "2006", "]", ",", ...
PMC11658074	d Schematic diagram of fat grafting and UVB irradiation on the back.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Schematic", "diagram", "of", "fat", "grafting", "and", "UVB", "irradiation"...
PMC9429973	Median prior lines of therapy was 3 (range, 2 to 6); no pts received prior HSCT and 6 pts received prior CAR-T. At a median follow-up of 6.9 months (range, 2.3 to 14.1), the most common treatment emergent adverse events (TEAE) were fatigue (n=5), anemia (n=4) and constipation (n=4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8998437	The mRNA expression levels of the genes of interest were normalized to the mRNA expression levels of the housekeeping gene TBP (encoding TATA box-binding protein).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11751675	These, as well as nine other sesquiterpene lactones (4, 22–29) previously isolated from this herb, were all tested for their anti-PR8 activity using both the cytopathogenic effect (CPE) reduction and cell counting kit 8 (CCK8) assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9847912	Our findings also suggest that GSK232 is not a suitable candidate for antiretroviral therapy of HIV-2 infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "also", "suggest", "that", ...
PMC11129910	We also looked at the expression level of the transcription factor Snail in spindle cell carcinoma cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "looked", "at", "the", "expres...
PMC7338939	The mathematical model provides the opportunity to improve the therapy by considering killing factors, depicted on top of each plot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mathematical", ...
PMC9429973	The top down-regulated genes in RT compared to CLL included CD79B (B-cell receptor signaling), CD160 (checkpoint pathway), KLF2 and CD40LG (T-cell regulation), CIITA (IFNg signaling) and SELL (cell adhesion).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11588008	For standby, three to five generations were maintained.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "standby", ",", "three", "to", "five", "generations", "were", "maintained", "." ] } ]
PMC9684669	Upper panel: Western blot analysis of p-CAMKII (T286), CAMKII (pan), p-CREB1 (s133), CREB1, ABCB1, and BIRC5 in MDR ovarian cancer cells treated for 24 hours with terfenadine (Ter).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055510	Schematic diagram of circMAN1A2 overexpression and knockdown sites. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematic", "diagram", "of", "circMAN1A2", "overexpression", "and", "knockdown", "sites", ".", "(" ] ...
PMC9429973	Clinical parameters (number of VOCs, hospitalizations, days hospitalized, ACS events, and blood transfusions) were documented for the year prior to treatment initiation as baseline values.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10212663	Nuclear factor‐κB receptor activator ligand (RANKL) is a member of the tumor necrosis factor superfamily (TNFSF), encoded by the TNFSF11 gene, and is the shared ligand for RANK and osteoprotegerin (OPG) (fellow TNFSF members).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11736898	In contrast, VID400, which is specific for CYP24A1, significantly increased CYP24A1 expression, suggesting that it increased local vitamin D levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	J. Liu, E. Jiang Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China Background: Hematological patients are at higher risk of developing carbapenem-resistant Enterobacteriaceae (CRE) bloodstream infection (BSI) and associated with high mo...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	No imputation for missing data was used; endpoints were summarized descriptively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "imputation", "for", "missing", "data", "was", "used", ";", "endpoints", ...
PMC4277423	We constructed lentiviral vectors expressing Cas9 and CCR5 sgRNAs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "constructed", "lentiviral", "vectors", "expressing", "Cas9", "and", "CCR5", "sgRNAs", "." ] } ]
PMC9681981	C. perfringens uses a complex network of toxin gene expression regulators, including the two-component regulatory system (TCR) and accessory gene regulator (Agr)-like quorum sensing (ALQS), to regulate the gene expression of various toxins (Vidal et al., 2009 ▶; Ohtani, 2016 ▶; Ohtani and Shimizu, 2016 ▶).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11545737	In contrast, a prevalence of GSDMD-mediated pyroptosis was observed in the brains of meningococcus-infected BALBc mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "In", "contrast", ",", "a", "prevalence",...
PMC10452486	The B2m-free HC molecules arose late in their biosynthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "B2m-free", "HC", "molecules", "arose", "late", "in", "their", "biosynthesis", "." ] } ]
PMC9599726	We also provide evidence that inhibition of YAP by verteporfin (VP) promotes ferroptosis in GIST cells while, surprisingly, CA3 mediates ferroptosis independently of YAP inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782508	The antibacterial activity of the purified azurin was evaluated against Gram-negative bacteria Escherichia coli (ATCC 8739), Klebsiella pneumoniae (ATCC 13883), and Gram-positive bacteria Staphylococcus aureus (ATCC 25923), and Bacillus subtilis (ATCC 6633) using the agar well diffusion method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Fluorescence in situ hibridation (FISH) studies were performed either on paraffin tissue sections or bone marrow smears using Vysis LSI MYC, BCL2, BCL6 Dual color break apart probes and Vysis IGH/MYC/CEP 8 Tri-Color Dual Fusion probes (Abbott Molecular, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8839885	Results demonstrated that exposure to RJY13 caused substantial cleavage of PARP1 as indicative of apoptosis induction and direct co-culture with MS-5, blocking the ability of RJY13 to stimulate PARP1 cleavage (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In pts with both del(17p) and TP53 mutation (n=111) vs those with either (n=19), ORR was 75% vs 79%; mPFS was 27.4 vs 22.8 mo (P=.8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10253973	The findings showed that complexes of Ru(II) mostly inhibit the accumulation of β-amyloid aggregates, scavenge intracellular ROS, reduce mitochondrial degradation and maintain the correct level of matrix metalloproteinases (MMPs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11799978	The Incucyte 96-well Woundmaker Tool (Essen) was employed to create wounds across all wells of the plate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Incucyte", "96-well", "Wou...
PMC6379402	We apply the same methodology to measure the cancer driver enrichment in the top-500 most rewired always-expressed genes, and in the pan-cancer study on the pan-cancer expressed genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11682224	The angiogenesis experiment’s findings showed that the angiogenesis rate in the CHD1L-OE group was much higher than in the NC group, while it was significantly lower in the CHD1L-KD group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11345828	Mice were group-housed under pathogen-free and controlled environmental conditions and handled according to the institutional, governmental and European Union guidelines (Austrian Animal Protection Laws, GV-SOLAS and FELASA guidelines).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755467	The raw data were analyzed using ShapeMapper2, a tool created specifically for the analysis of SHAPE data by Busan and Weeks in 2018 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Kd was used in L2(6%), L3 (17.2%) and L4+ (76.8%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kd", "was", "used", "i...
PMC10968586	The 48 h incubation with the same concentrations of OLE and HT led to caspase-3-mediated apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "48", "h", "incubation", "with", "the", "s...
PMC11627398	Thus, SLC31A1 may promote the progression of septic shock through activating MAPK signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "SLC31A1", "may", "promote", "the", "progression", "...
PMC11707577	typically fail.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "typically", "fail", "." ] } ]
PMC10669128	In fact, the in vitro and in vivo drug response of certain cell lines was not frequently recapitulated in numerous clinical trials .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC9429973	In the 3 cases with no karyotype results at the initial onset, t(8;14)(q24.1;q11.2) was detected in relapse specimens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "3", "case...
PMC9429973	Markedly elevated serum ferritin (10271 ng/mL), triglycerides (618 mg/dL) and soluble CD25 (5119 pg/ml,) supported a diagnosis of HLH (6 of 8 HLH-2004 criteria and HScore 268 points) the patient immediately started treatment with dexamethasone 10 mg/m per day.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The most frequent treatment-emergent adverse events (TEAE) were neutropenia (51%), fatigue (39%), and CRS (38%), with grade 3 CRS in 1 patient (2%) and no grade 4/5 CRS events.

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PMC11461874

Statistical significance was determined for genotype, time and interaction by two-way ANOVA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "was", "determined", "for", "genotype", ",", ...

PMC10988808

I Quantitative analysis of CCDC25.

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PMC9611901

It is clear to us that prohibited substances may no longer be used in processing of leather, but for the purpose of experiments it is allowed to compare the effects of prohibited substances with those whose use is permitted.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4355729

The decrease of CTNNB1 protein was also observed in 786-mut1 shCTNNB1 and A-704-mut2 shCTNNB1 cells (P < 0.01; P < 0.01) (Fig. 6a).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11381192

All cells were cultured in RPMI‐1640 medium (Gibco, USA) supplemented with 10% foetal bovine serum (Biological Industries, Israel) and 1% penicillin–streptomycin (Beyotime Biotechnology, Shanghai, China).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10203589

In addition, blocking Wnt pathway significantly decreased the mRNA and protein expression levels of FGF18 and affected the colony formation of CD44-LT97 cells (68).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11794847

Additionally, while we did observe a relationship between HVEM and GPT2, further studies are needed to decipher the intricate molecular mechanisms at play.

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PMC11451940

Both assays were carried out in accordance with the manufacturers' protocols, with a modification in the caspase induction assay: we used the CellEvent™ Caspase-3/7 green detection reagent only for detecting caspase-3/7 activation.

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PMC11525028

Views of ac4C modification peaks of ATF4 in the 143B cell line from acRIP-seq. (

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PMC9019892

β‐actin antibody was purchased from TransGen Biotech (Beijing, China; no. HC201‐02).

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PMC10870498

The primers used in cell transfection were synthesized by Sangon and listed in Table 1.

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PMC11247842

Annotation file: the regulator elements and CpG islands annotation file were reformatted for GARFIELD.

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PMC6892818

Therefore, mCD40L regulates early signalling events in renal cells and, more importantly, TRAF2 and TRAF3 regulation is fundamentally different between normal and malignant cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11279397

Additionally, germacron dose-dependently inhibited Pseudo rabies virus (PRV) replication in vitro and displayed antiviral activity against PRV during the initial phases of viral replication.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10745221

Recent studies have pointed to the role of S-adenosylmethionine-dependent protein arginine methyltransferases (PRMTs) in cell proliferation and cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", ...

PMC8540611

In experiments to determine cell death after 2 days of incubation, the uptake level did not drop so much, but remained at 30% for CEM-SS cells and 15% for HL-60 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

IBER is being investigated for the treatment of relapsed/refractory MM (RRMM) in a phase 1/2 study (NCT02773030).

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PMC10165258

Schematic of the consecutive steps toward addition of multiple secondary droplets to primary droplets.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematic", "of", "the", "consecutive", "steps", "toward", "addition",...

PMC11658074

4Surface protein sequences and EV subpopulations of AT-EVs and ADSC-EVs.

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PMC10669128

Through this model, they reproduced gastrointestinal pathology in mice with remarkable penetrance, demonstrating that the constitutive activation of KIT signaling is pivotal and sufficient to cause neoplastic growth in mice .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Cytotoxic capacity, T cell proliferation and cytokine secretion were assessed.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytotoxic", "capacity", ",", "T", "cell", "proliferation", "and", "cytokine", "secretion", ...

PMC7887261

In the seven validation datasets, of the 25 candidates, 100% were covered by the gnomAD, 22 (88%) in TCGA, 16 (64%) in COPDGene, nine (36%) in GELCC, and nine (36%) were covered in one of the three case–control studies (OncoArray, Affymetrix, and UKB) with genotyping data.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9592219

We assessed the progress of wound healing and compared the results with the initial measurements.

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PMC11271278

To determine what types of enhancers are interacting with HAPI genes, the trans and long-range cis interaction data sets with enhancer contact values and interaction intensity calculated for each gene as described above are used.

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PMC9429973

In this group, 88% of pts died in the short term without achieving remission, the remaining 12% of pts had short-term remission.

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PMC7185206

Karpas-299 cells were treated with vehicle control versus TAPI-2, recombinant human ADAM10, or recombinant human ADAM17 over 24 h and PD-L1 positive cells were measured by flow cytometry.

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PMC11770130

Ribosome pulldown was conducted as previously described, with modifications.

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PMC9429973

AEs leading to discontinuation were reported in 2 new pts since the previous data cutoff; both pts discontinued and died due to COVID-19.

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PMC11422150

Additionally, flow cytometry of bone marrow revealed suppressed production of M-MDSCs (Figure 6B), and production of M1 macrophages was also inhibited by hAMSC treatment (Figure 6C).

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PMC11257988

Drugs targeting MEK downstream in the MAPK cascade via inhibition of signal transduction pathways are less effective in treating KRAS-mutant NSCLC in multiple experiments.

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PMC4485786

In sharp contrast, up to 70% of the sarcoma cells from mice treated with either NHS-IL12/IL-2MAB602 or NHS-IL12/FcIL-7 expressed the senescence marker p-HP1γ or p16 (Fig. 5A, B), in the absence of PCNA (PCNA/p-HP1γ) (Fig. 5A, upper line inserts) and Ki67 (Ki67/p16) (Fig. 5A, lower line inserts).

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PMC11297139

p < 0.001.

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PMC11721587

To evaluate the dynamics Hh-induced Fu condensates, Cl8 cells were transfected with mEGFP-Fu and treated with Hh-conditioned medium for 16 hours.

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PMC11765243

As we see below, altered Treg differentiation was consistently observed in distinct conditions in p110αKD-T mice.

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PMC11635519

We designed a structure that encodes a fusion protein to display the MCP1 peptide on the cell surface.

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PMC10547921

The carboxylic acid-containing thailanstatin semi-synthetic analog 87 was directly coupled to trastuzumab surface lysine to obtain a very effective thailanstatin ADC.

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PMC11632064

Interestingly, the pro-inflammatory effects of BRD7389 could not be observed in A-375 above 300 nM due to cell death (Fig 1H).

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PMC5672695

The glutathione-S-transferase T1 (GSTT1) and glutathione-S-transferase M1 (GSTM1) polymorphisms were examined using the polymerase chain reaction method.

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PMC9429973

Understanding the needs of these patients will enable healthcare providers to properly support them.

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PMC11337594

Ileitis in mice with FADD-deficient intestinal epithelial cells can be driven by necroptosis or GSDMD-dependent pyroptosis .

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PMC11746942

Moreover, the deletion of Stat3 in keratinocytes but not in T cells reduced psoriasis-like dermatitis, indicating that persistent STAT3 activation in keratinocytes leads to the pathogenesis of psoriasis.

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PMC11391695

In 96-well plates, HCC cells were seeded at a density of 3000 cells per well.

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PMC11772585

K The mobility and invasiveness were assessed by trans-well migration assay and matrigel invasiveness measurement (n = 5), respectively.

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PMC11697703

We first confirmed the specificity of the miR-193b∼365 cluster to corticospinal projection neurons in independent samples of purified corticospinal and callosal projection neurons on postnatal day (P) 2, and compared the relative quantity (RQ) of miRNA in corticospinal relative to callosal projection neurons via qPCR.

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PMC11343332

Target gene expression is normalized to GAPDH mRNA expression, and the results are expressed as a fold change from the control.

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PMC10454535

Treatments for MM include proteasome inhibitors, immunomodulators, monoclonal antibodies, corticosteroids, histone deacetylase inhibitors, and radiation therapy .

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PMC10568263

The Au@MnO2 precipitates were dried in an oven at 60 °C for 12 h. Finally, the Au@MnO2 precipitates were added to the DI water to obtain 3/10 by weight aqueous solutions of Au@MnO2 for further use.

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PMC6468656

Ghrelin, a peptide hormone, has been reported to promote cancer metastasis and is clinically associated with poor survival in various types of cancers .

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PMC11252553

Radiation has a range of biological effects on cells, and one of the most significant outcomes is cell death, resulting in the loss of reproductive ability.

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PMC11095939

A total of 647 proteins were identified as putative Mecp2 interactors.

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PMC10154097

This assay was performed to separate cell nuclear and cytoplasmic fractions according to previously described procedures using PARIS™ Kit (Ambion, Austin, TX, USA) followed by measuring circSOX4 level by qRT-PCR.

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PMC9429973

RVU120 is administered orally, each other day for 7 total doses per 21 days cycle, until disease progression/unacceptable toxicity.

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PMC11495567

Image Lab Software was used to quantify the chemiluminescence images that were then normalized against GAPDH and the controls and then plotted against the PCAIs concentrations.

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PMC9429973

Twelve pts (6.2%) switched to other BTKis and 5 pts (2.6%) did so for HTN.

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PMC8633974

To conclude, the combination of “diverse” strain-inactivating TatD and “tri-exon”-directed TatE gRNAs prompted maximal suppression of HIV-1 replication by CRISPR-Cas9.

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PMC10530622

However, glycine’s contribution to oxalate production is very small .

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PMC11731161

D Cell apoptosis rates of different MM cell lines after treated with indicated concentrations of SEL for 48 h. E Representative immunoblotting images and quantitative analysis of XPO1 protein levels in different MM cell lines treated with increasing concentrations of SEL for 24 h. F and G Immunofluorescent staining of ...

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PMC11637276

MDA-MB-231 cells were transfected with an siRNA targeting α2 integrin (siITGA2) or non-targeting siRNA control (siNT) and spheroids were embedded in 2 mg/ml collagen I and matrigel (1:1 ratio) matrix for 3 days.

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PMC10605143

We found that an increase in its expression may affect the intrinsic ability of human mammary epithelial cells to acquire mesenchymal characteristics.

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PMC4112127

Further studies are now indicated in biospecimens of patients at high risk for CC, such as those with PSC, to assess the value of BMP3 and other methylation markers for screening or early detection of CC in biospecimens such as bile, bile duct brushings, blood or stool.

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PMC2614416

With BLASTP 2.2.15 [Oct-15-2006], mapping now includes RefSeq.

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PMC11658074

d Schematic diagram of fat grafting and UVB irradiation on the back.

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PMC9429973

Median prior lines of therapy was 3 (range, 2 to 6); no pts received prior HSCT and 6 pts received prior CAR-T. At a median follow-up of 6.9 months (range, 2.3 to 14.1), the most common treatment emergent adverse events (TEAE) were fatigue (n=5), anemia (n=4) and constipation (n=4).

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PMC8998437

The mRNA expression levels of the genes of interest were normalized to the mRNA expression levels of the housekeeping gene TBP (encoding TATA box-binding protein).

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PMC11751675

These, as well as nine other sesquiterpene lactones (4, 22–29) previously isolated from this herb, were all tested for their anti-PR8 activity using both the cytopathogenic effect (CPE) reduction and cell counting kit 8 (CCK8) assays.

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PMC9847912

Our findings also suggest that GSK232 is not a suitable candidate for antiretroviral therapy of HIV-2 infection.

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PMC11129910

We also looked at the expression level of the transcription factor Snail in spindle cell carcinoma cases.

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PMC7338939

The mathematical model provides the opportunity to improve the therapy by considering killing factors, depicted on top of each plot.

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PMC9429973

The top down-regulated genes in RT compared to CLL included CD79B (B-cell receptor signaling), CD160 (checkpoint pathway), KLF2 and CD40LG (T-cell regulation), CIITA (IFNg signaling) and SELL (cell adhesion).

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PMC11588008

For standby, three to five generations were maintained.

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PMC9684669

Upper panel: Western blot analysis of p-CAMKII (T286), CAMKII (pan), p-CREB1 (s133), CREB1, ABCB1, and BIRC5 in MDR ovarian cancer cells treated for 24 hours with terfenadine (Ter).

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PMC11055510

Schematic diagram of circMAN1A2 overexpression and knockdown sites. (

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PMC9429973

Clinical parameters (number of VOCs, hospitalizations, days hospitalized, ACS events, and blood transfusions) were documented for the year prior to treatment initiation as baseline values.

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PMC10212663

Nuclear factor‐κB receptor activator ligand (RANKL) is a member of the tumor necrosis factor superfamily (TNFSF), encoded by the TNFSF11 gene, and is the shared ligand for RANK and osteoprotegerin (OPG) (fellow TNFSF members).

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PMC11736898

In contrast, VID400, which is specific for CYP24A1, significantly increased CYP24A1 expression, suggesting that it increased local vitamin D levels.

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PMC9429973

J. Liu, E. Jiang Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China Background: Hematological patients are at higher risk of developing carbapenem-resistant Enterobacteriaceae (CRE) bloodstream infection (BSI) and associated with high mo...

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PMC9429973

No imputation for missing data was used; endpoints were summarized descriptively.

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PMC4277423

We constructed lentiviral vectors expressing Cas9 and CCR5 sgRNAs.

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PMC9681981

C. perfringens uses a complex network of toxin gene expression regulators, including the two-component regulatory system (TCR) and accessory gene regulator (Agr)-like quorum sensing (ALQS), to regulate the gene expression of various toxins (Vidal et al., 2009 ▶; Ohtani, 2016 ▶; Ohtani and Shimizu, 2016 ▶).

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PMC11545737

In contrast, a prevalence of GSDMD-mediated pyroptosis was observed in the brains of meningococcus-infected BALBc mice.

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PMC10452486

The B2m-free HC molecules arose late in their biosynthesis.

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PMC9599726

We also provide evidence that inhibition of YAP by verteporfin (VP) promotes ferroptosis in GIST cells while, surprisingly, CA3 mediates ferroptosis independently of YAP inhibition.

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PMC11782508

The antibacterial activity of the purified azurin was evaluated against Gram-negative bacteria Escherichia coli (ATCC 8739), Klebsiella pneumoniae (ATCC 13883), and Gram-positive bacteria Staphylococcus aureus (ATCC 25923), and Bacillus subtilis (ATCC 6633) using the agar well diffusion method.

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PMC9429973

Fluorescence in situ hibridation (FISH) studies were performed either on paraffin tissue sections or bone marrow smears using Vysis LSI MYC, BCL2, BCL6 Dual color break apart probes and Vysis IGH/MYC/CEP 8 Tri-Color Dual Fusion probes (Abbott Molecular, USA).

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PMC8839885

Results demonstrated that exposure to RJY13 caused substantial cleavage of PARP1 as indicative of apoptosis induction and direct co-culture with MS-5, blocking the ability of RJY13 to stimulate PARP1 cleavage (Figure 1B).

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PMC9429973

In pts with both del(17p) and TP53 mutation (n=111) vs those with either (n=19), ORR was 75% vs 79%; mPFS was 27.4 vs 22.8 mo (P=.8).

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PMC10253973

The findings showed that complexes of Ru(II) mostly inhibit the accumulation of β-amyloid aggregates, scavenge intracellular ROS, reduce mitochondrial degradation and maintain the correct level of matrix metalloproteinases (MMPs).

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PMC11799978

The Incucyte 96-well Woundmaker Tool (Essen) was employed to create wounds across all wells of the plate.

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PMC6379402

We apply the same methodology to measure the cancer driver enrichment in the top-500 most rewired always-expressed genes, and in the pan-cancer study on the pan-cancer expressed genes.

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PMC11682224

The angiogenesis experiment’s findings showed that the angiogenesis rate in the CHD1L-OE group was much higher than in the NC group, while it was significantly lower in the CHD1L-KD group.

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PMC11345828

Mice were group-housed under pathogen-free and controlled environmental conditions and handled according to the institutional, governmental and European Union guidelines (Austrian Animal Protection Laws, GV-SOLAS and FELASA guidelines).

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PMC11755467

The raw data were analyzed using ShapeMapper2, a tool created specifically for the analysis of SHAPE data by Busan and Weeks in 2018 .

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PMC9429973

Kd was used in L2(6%), L3 (17.2%) and L4+ (76.8%).

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PMC10968586

The 48 h incubation with the same concentrations of OLE and HT led to caspase-3-mediated apoptosis.

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PMC11627398

Thus, SLC31A1 may promote the progression of septic shock through activating MAPK signaling.

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PMC11707577

typically fail.

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PMC10669128

In fact, the in vitro and in vivo drug response of certain cell lines was not frequently recapitulated in numerous clinical trials .

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PMC9429973

In the 3 cases with no karyotype results at the initial onset, t(8;14)(q24.1;q11.2) was detected in relapse specimens.

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PMC9429973

Markedly elevated serum ferritin (10271 ng/mL), triglycerides (618 mg/dL) and soluble CD25 (5119 pg/ml,) supported a diagnosis of HLH (6 of 8 HLH-2004 criteria and HScore 268 points) the patient immediately started treatment with dexamethasone 10 mg/m per day.

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