OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11711127	In a similar vein, inclusion of a stimulatory step is widely adopted in tolerogenic DCs (tolDCs) protocols, and logically makes sense in order to ensure utilisation of mature DC characteristics—e.g. migration and peptide-MHC (pMHC) presentation—that allow engagement with T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740207	VSELSCs may also originate from MdPCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "VSELSCs", "may", "also", "originate", "from", "MdPCs", "." ] } ]
PMC11089031	It is necessary to identify new biomarkers that can serve as indicators for the detection of ccRCC at its early stages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "neces...
PMC8658661	However, it has been shown that the titers of the BSEP protein, which carry bile salts, are 100 times lower in HepG2 cells than in hepatocytes , which is consistent with studies of the mRNA level .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC10669128	Visceral sarcomas are a rare malignant subgroup of soft tissue sarcomas (STSs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Visceral", "sarcomas", "are", "a", "rare", "malignant", "subgroup", ...
PMC9841531	San Diego, CA).	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "San", "Diego", ",", "CA", ")", "." ] } ]
PMC7723249	All data together suggest that CCHFV and HAZV receptors have different localization on polarized Caco-2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "All", "data", "together", "suggest", "that", ...
PMC9429973	This demonstrates the importance of the MDT in ensuring pathologists play an active role in the diagnosis and that their reports are not misinterpreted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Carfilzomib was well tolerated, with grade 2 anemia in 39% (16/41) of patients,successfully managed by ESAs, without necessity of blood transfusions; 29%(12/41) grade 3-4 neutropenia (pegfilgrastim in primary prophylaxis wasgiven, no ospedalization was required, no septic shocks were observed); 34%(14/41) grade 2, 21% ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: Mouse embryonic stem cells (mESC) were cultured and treated with Yoda-1 and GsMTx4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Mouse", "embryonic", "stem", ...
PMC10788478	LGR6 mRNA expression data in lung adenocarcinoma samples were obtained from the TCGA database (http://cancergenome.nih.gov/) as previously described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LGR6", "mRNA", "expression",...
PMC8875242	In keeping with previous studies , we observed no ABCB1 inhibitory activity for abacavir, tenofovir DF, or zidovudine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "keeping", "with", ...
PMC3675084	In the paclitaxel-resistant cells, mitotic catastrophe is the major cell death pathway; it has reported that mitotic catastrophe can proceed via caspase-3 dependent or independent pathways , .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9512971	The plasma concentration of GBPA was predicted to exceed the EC50 for at least 11.5 h at the dose used (2400 mg/day) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11592837	In automated microscopy, PBMCs treated with ETP displayed a visible increase in proportion of γH2AX-positive cells after 0.5 h of incubation, becoming significant after 1 h (p < 0.01) with a maximum after 2 h (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: The safety profile of bosutinib after 5 years follow-up, with a focus on gastrointestinal, liver, effusion and renal treatment-emergent adverse events (TEAEs), was characterized.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Since TPO is a key regulator of both HSC and Mk, we investigated the dual role of TPO defect in the disease model of BT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11066331	Robustness of developed method was tested using mass spectra recorded in different technical replicates prepared separately on different days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Robustness", "of", "developed", "...
PMC11088135	YAP1 is highly expressed in human glioma, and it may serve as a reliable prognostic biomarker and therapeutic target for glioma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "YAP1", "is",...
PMC11562028	The size distribution of the Re-CDs was uniform, and concentrated in the 1–4 nm size range.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "size", "distribution", "of", "the", ...
PMC11733919	In the present study, we have designed a nanoplatform composed of iron oxide nanoparticles functionalized with an antibody against a cell surface marker of senescent cells (CD26), and loaded with the senolytic drug HSP90 inhibitor 17-DMAG (MNP@CD26@17D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11350568	Designing a hyperefficient TMPDS. (	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Designing", "a", "hyperefficient", "TMPDS", ".", "(" ] } ]
PMC11345828	To address this, we envisioned replacing the 1,3,5-trimethylpyrazole with a symmetrical heteroaryl group and thereby removing the site of axial chirality.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "addres...
PMC10976516	However, the ultimate challenge for OV therapy is not only the eradication of locally injected tumor lesions but also all metastases, especially in advanced cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	The phenylalanine-free diet contained all the same nutrients as the control diet, except for phenylalanine and corn starch.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "phenylalanine-free", "diet", ...
PMC9424261	Cancer is a major public problem in all countries of the world, and it is the leading cause of shortening lifespan and leading to death .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC5916734	We previously developed plasmid vectors, p1.1 and p1.2, based on the untranslated regions of the translation elongation factor 1 alpha gene from Chinese hamster.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC6364197	Importantly, we found that the molecular mechanisms of cell survival and drug resistance observed in the scaffold were similar to those reported in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	A. Röth, W. Barcellini, S. D’Sa, Y. Miyakawa, C. M. Broome, M. Michel, D. J. Kuter, B. Jilma, T. H. A. Tvedt, I. C. Weitz, T. Sourdille, J. Wang, D. S. Vagge, K. Kralova, F. Shafer, M. Wardecki, M. Lee, S. Berentsen Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital E...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5673060	Dose response curve of PazR cells to pazopanib or NVP-AUY-922 treatment. (	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dose", "response", "curve", "of", "PazR", "cells", "to", "pazopanib", "...
PMC9429973	Neither patient who received pomalidomide and dexamethasone or elotuzumab with lenalidomide and dexamethasone responded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Neither", "patient", "who", "received", "pomalidomide", "and", "dexame...
PMC9429973	Infusion reactions occurred in 2 patients (13%), one of them experienced anaphylactoid reaction that required infusion interruption.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Infusion", "reactions",...
PMC9429973	A gene editing platform using homology directed repair (HDR) that replaces the HBB gene to achieve a normal or β-thalassemia trait phenotype with HbA expression similar to healthy individuals is an ideal strategy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782508	EDX was employed to determine the elemental composition of the purified azurin (Fig. 5b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EDX", "was", "employed", "to", "determine", "the", ...
PMC10329237	Also, another study showed that LOS treatment significantly decreases migration in pancreatic stellate cells (50).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "another", "study", "showe...
PMC9960565	After freeze-drying, a light gray hygroscopic powder was obtained with a yield of 58% (0.13 g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "freeze-drying", ","...
PMC9429973	The absence of a resistance mutation influenced choice of therapy in another 4 patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "absence", "of", "a", "resistance", "mutation", "influenced", ...
PMC11552389	12741, Cell Signaling Technology, Danvers, MA), rinsed, and probed for 30 minutes using secondary AF488-anti-mouse IgG (Invitrogen).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11521786	Considering the benefits of active immunotherapy and studies suggesting the antitumoral advantages of a polyclonal response over monoclonal antibodies (25–27), developing a vaccine against HER3 could be a strategy for treating cancers in which the activation of this receptor plays a fundamental role.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9351137	These subunits are structurally and functionally orthologous to human MRG15, Tip60, and CFDP1, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "subunits", "are", "structurally", "and",...
PMC10291556	The full horizontal line indicates the level of phagocytosis of the untreated control cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "full", "horizontal", "line", "indicates", "the", "level", ...
PMC10745221	Hyblot Cl) at -80°C for 63 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hyblot", "Cl", ")", "at", "-80", "°", "C", "for", "63", "days", "." ] } ]
PMC11591052	These data imply the activation of the PI3K/AKT/mTOR pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "imply", "the", "activation", "of", "the", "PI3K/AKT/mTOR", "pathway", "." ] } ]
PMC10998613	These results support the interpretation that β2AR associates with CXCR4 multimers in this cancer cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O" ], "tokens": [ "These", "results", "support", "the", ...
PMC11679892	In this study, only the neuroblastoma cell line was examined, and no reference cell line was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", ...
PMC10988555	The A2780 cell line was seeded in 25 cm T-flasks at a density of 2 × 10 cells/T-flasks.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "A2780", "cell", "line", ...
PMC11767793	Then, we discuss their qualification for positive and negative controls when applied in the in vitro cytotoxicity screening of MNMs in the context of previously defined requirements for such applications .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We applied Mass-Spectometry analysis of AML blasts and AML- or h-MSCs co-cultured for 21 days in 3D, finding a total of 15 differentially new synthesized secreted factors in the 3D medium of co-cultures with the AML blasts, related to inflammation, angiogenesis and cancer pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	Based on the Koff and the respective EC50 value, we calculated the on-rate Kon for each agonist.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "the", "Koff", "and", ...
PMC11705901	Likely candidates would be by influencing the functional expression of other polymorphisms, and epigenetic processes such as methylation of the OXTR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Likely", "ca...
PMC7917457	The B16.F10.9/K1 clone is considerably more responsive to cancer immunotherapies than the highly immunosuppressive parental strain B16.F10.9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "B16.F10.9/K1", "clone", "is", "considerabl...
PMC11317131	Next, we observed phage numbers plateau, likely due to the integrase variants reaching a point of hyperactivity that they were no longer challenged by the current level of stringency, necessitating increases in stringency for continued productive evolution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11310713	The electrostatic extrusion method was used to produce GTB, as shown in the scheme.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "electrostatic", "extrusion", "method", "was", "used", ...
PMC11509309	CHO-K1 cells were treated with tunicamycin (Tm), an antibiotic that induces ER stress by inhibiting protein N-glycosylation , which triggers UPR and cell death.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	Cholesterol is another important regulator of cell proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cholesterol", "is", "another", "important", "regulator", "of", "cell", "proliferation", "." ] } ]
PMC9429973	This inherited disorder causing hemolytic anemia, due to membrane proteins abnormalities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "inherited", "disorder", "causing", "hemolytic", "anemia", ",", "due", "t...
PMC11321678	Statistical analysis was performed by Prism 8 software or commercially available software (SPSS 22.0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", "performed", "by", "P...
PMC11773391	Cells were seeded in six‐well plates and grown to 70%–80% confluence; then, each well contained 5 × 10 cells and 5.0 μg MGMT‐Luc, according to the manufacturer's instructions for Lipofectamine 3000 (Thermo Fisher Scientific Inc.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11694066	Data on the PARPi plus ATRi combination in DSRCT are much scarcer for now: one heavily pretreated patient, who received the PARPi olaparib in combination with ATRi AZD6738 as part of the eSMART trial (NCT02813135), presented stable disease for 4 months of the study (15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	These future studies will be important for understanding the impact of IpaH4-eukaryotic host interactions to bacterial replication and pathogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "future", "studies", "wil...
PMC9429973	Summary/Conclusion: Our results demonstrated that Ulixertinib treatment reduced OPN production both in vitro and in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Our", "results", "demo...
PMC11637716	These included telomere length analysis, functional testing for Fanconi anaemia, followed by focused genetic testing for SAMD9, SAMD9L, GATA2 and RUNX1 mutations and then extended to a selection of genes involved in infantile myelodysplastic syndromes and BMF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9268620	The foil was coated with a thin layer of cold in a sputter coater (Polaron E5100, SEM Coating Unit, Hertfordshire, UK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11496491	A boxplot of the standardized strength values for each of the two sets of samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "boxplot", "of", "the", "standardized", "strength", "va...
PMC11525028	Then ITC assay was utilized to validate the interactions of both inhibitors with NAT10 (Figure 6D), and the titration curve showed that paliperidone (KD = 12.8 ± 8.72 μM) and AG-401 (KD = 1.92 ± 0.87 μM) could bound to NAT10 protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10154097	Decreased miR-218-5p might be a marker of bone metastasis in prostate cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Decreased", "miR-218", "-", "5p", "might", "be", "a", "marker", ...
PMC9429973	Moreover, both CD4+ and CD45RO+ markers, a characteristic immunophenotype of Sezary cells, represented subpopulations with a higher basic expression of TMEM244, suggesting the involvement of this gene in the disease onset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11566417	Lysis was repeated, after which cells were washed once by centrifugation with PBS and resuspended in RPMI medium (Corning) + 1% HEPES (Thermo Fisher).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748363	The latter compounds were advanced into testing against the virulent strain Mtb H37Rv, where they were found to preserve their antimycobacterial activity (MIC = 6.25 μg/mL), M. avium , and M. kansasii (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8427838	Moesin is highly enriched at the sites of cellular protrusions such as filopodia, microvilli and microspikes, and has been proposed to positively regulate cell migration in different cell types .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11785489	After all, the TCR sequence is only one minor influence on the transcriptional state of a given T cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "all", ",", "t...
PMC10006224	For the boxplot analysis in Supplementary Fig. 6e, signals for each protein and condition were obtained ±150-bp around peak summits and log2 fold change between NIPBL KD and control was calculated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10698968	Graph shows single DTs (dots) calculated from exponential growth equations (example shown in C), with mean (lines).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10823017	The control group had 86% live cells along with only 2% cells with early apoptosis and 1.37% cells with late apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9577200	Given the natural materials evaluation scenario as antibacterial and anticancer agents, the increase in antibiotic use has resulted in the emergence of antibiotic-resistant bacteria that have a dangerous impact on human health.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	L. Largeaud, M. Collin, N. Monselet, F. Vergez, L. Larcher, P. Hirsch, N. Duployez, J. Bustamante, C. Bellanné-Chantelot, J. Donadieu, F. Sicre de Fontbrune, M. Nolla, C. Fieschi, F. Delhommeau, E. Delabesse, M. Pasquet Clinical Haematology laboratory, Toulouse Hospital; UMR1037, Cancer Research Center of Toulouse, Tou...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10850553	IA lesions (Aneurysm) or control arterial walls (Superficial temporal artery) were harvested subjected to immunohistochemical analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IA", "lesions", "(", "...
PMC11519583	Recent studies have shown that attenuated proliferation and adipogenic differentiation are representative phenotypes of MPs derived from aged mice .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "show...
PMC11687167	Three isoforms of SREBP, SREBP1a, SREBP1c, and SREBP2, have been identified, each of which plays a different role in lipid synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11543885	Timing: 1–2 weeks Timing: 1–2 weeks Here we describe steps for the transfection and generation of a stable flag-NLRP3-APEX2 expression HEK293 cell line.16.Maintenance of Flp-In T-REx HEK293 cells.a.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11635519	This overlap is crucial for ensuring complete epitope presentation, including epitopes that span the boundaries between peptides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "overlap", "is", "crucial", "fo...
PMC2777936	To determine if stable repression of FZD5 or FZD7 in EC cells induced differentiation, expression of immunophenotypic differentiation-specific extracellular markers recognized by A2B5 and SSEA-3 were each examined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	CMML cases driven by mutations in RAS pathway signaling genes or ASXL1 have a higher risk of failure and progression to acute myeloid leukemia (AML).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11023271	Serum also contains extracellular DNA and RNA (for example microRNA), which may serve as the serum factor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Serum", "also", "contains", ...
PMC11391695	Following encapsulation of the pcDNA-ACYP2 vector within PEI/NPs, the NPs were coated with HCC cell membranes (pcDNA/PEI/NPs@M).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "encapsulation", ...
PMC9436459	Of these compounds, 6, 31, 40, and 57 were found to be potent multi-targeted agents for AD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "these", "co...
PMC11521786	Treated cell viability percentage was calculated using the following formula: cell viability (%) = (OD treated cell540–630 nm)/(OD nontreated cell540–630 nm) × 100.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730000	mTOR protein expression levels were decreased in the DOX group compared with the control group (Figure 7A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "mTOR", "protein", "expression", "...
PMC9429973	The fifth patient progressed within the first yr after ASCT and received VRD+dara.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fifth", "patient", "progressed", "within", "the", "first", "yr", ...
PMC8097906	The analysis of cell migration capacity under treatment with different concentrations of plant extracts (VSM and LW) and plant-derived compounds (Geni, Seco, Mata, Daid and Jaspl.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Immunophenotypic analysis on the NK cell product was performed before and after the expansion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunophenotypic", "analysis", "on", "the", "NK", "cell", "product", ...
PMC10874773	Seco-prezizaane-type sesquiterpenes (SPS, Fig. 1A), as a class of sesquiterpenes, are known to be derived from bond cleavage in the backbone of prezizaanes (Li, Shen, & Zhang, 2016), which have a highly oxygenated fused tetra- or penta-cyclic structure with several continuous stereo centers (Kawamura et al., 2019), ori...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	Also, we introduce a computational prototype of an iCell, which integrates three omics, tissue-specific molecular interaction network types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "we",...
PMC9424261	TMT analysis was performed and analyzed by Luming Biotechnology (Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TMT", "analysis", "was", "performed", "and", "analyzed", "by", "...
PMC9927933	The growth suppression by UBE2C knockdown could be largely rescued by simultaneous DEPTOR knockdown in lung cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "growth", "suppression", "by", "...
PMC11476264	In the lung cancer database organized by Kaplan–Meier plot, analysis demonstrated that ZEB1 expression levels were negatively correlated with patient survival, and patients with high levels of FBXO11 expression in their tumors had higher overall survival rates and survived longer than patients with low levels of FBXO11...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8097906	However, established therapies often fail in advanced RMA and tumor relapse cases, rendering novel treatment strategies necessary .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "established", "th...
PMC7757104	Future work should evaluate their putative contribution to the resistant phenotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Future", "work", "should", "evaluate", "their", "putative", "contribution", "to", "the", ...
PMC11758416	Wash adhered cells with at least 10 mL sterile 1X PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wash", "adhered", "cells", "with", "at", "least", "10", "mL", "sterile", "1X", ...
PMC9429973	We isolated CDK6-containing protein complexes by immunoprecipitation followed by mass spectrometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "isolated", "CDK6-containing", "protein", "complexes", "by", "immunoprecipitation", "followe...

PMC11711127

In a similar vein, inclusion of a stimulatory step is widely adopted in tolerogenic DCs (tolDCs) protocols, and logically makes sense in order to ensure utilisation of mature DC characteristics—e.g. migration and peptide-MHC (pMHC) presentation—that allow engagement with T cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11740207

VSELSCs may also originate from MdPCs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "VSELSCs", "may", "also", "originate", "from", "MdPCs", "." ] } ]

PMC11089031

It is necessary to identify new biomarkers that can serve as indicators for the detection of ccRCC at its early stages.

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PMC8658661

However, it has been shown that the titers of the BSEP protein, which carry bile salts, are 100 times lower in HepG2 cells than in hepatocytes , which is consistent with studies of the mRNA level .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...

PMC10669128

Visceral sarcomas are a rare malignant subgroup of soft tissue sarcomas (STSs).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Visceral", "sarcomas", "are", "a", "rare", "malignant", "subgroup", ...

PMC9841531

San Diego, CA).

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "San", "Diego", ",", "CA", ")", "." ] } ]

PMC7723249

All data together suggest that CCHFV and HAZV receptors have different localization on polarized Caco-2 cells.

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PMC9429973

This demonstrates the importance of the MDT in ensuring pathologists play an active role in the diagnosis and that their reports are not misinterpreted.

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PMC9429973

Carfilzomib was well tolerated, with grade 2 anemia in 39% (16/41) of patients,successfully managed by ESAs, without necessity of blood transfusions; 29%(12/41) grade 3-4 neutropenia (pegfilgrastim in primary prophylaxis wasgiven, no ospedalization was required, no septic shocks were observed); 34%(14/41) grade 2, 21% ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Methods: Mouse embryonic stem cells (mESC) were cultured and treated with Yoda-1 and GsMTx4.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Mouse", "embryonic", "stem", ...

PMC10788478

LGR6 mRNA expression data in lung adenocarcinoma samples were obtained from the TCGA database (http://cancergenome.nih.gov/) as previously described.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LGR6", "mRNA", "expression",...

PMC8875242

In keeping with previous studies , we observed no ABCB1 inhibitory activity for abacavir, tenofovir DF, or zidovudine.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "keeping", "with", ...

PMC3675084

In the paclitaxel-resistant cells, mitotic catastrophe is the major cell death pathway; it has reported that mitotic catastrophe can proceed via caspase-3 dependent or independent pathways , .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9512971

The plasma concentration of GBPA was predicted to exceed the EC50 for at least 11.5 h at the dose used (2400 mg/day) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11592837

In automated microscopy, PBMCs treated with ETP displayed a visible increase in proportion of γH2AX-positive cells after 0.5 h of incubation, becoming significant after 1 h (p < 0.01) with a maximum after 2 h (Figure 2A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Aims: The safety profile of bosutinib after 5 years follow-up, with a focus on gastrointestinal, liver, effusion and renal treatment-emergent adverse events (TEAEs), was characterized.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Results: Since TPO is a key regulator of both HSC and Mk, we investigated the dual role of TPO defect in the disease model of BT.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11066331

Robustness of developed method was tested using mass spectra recorded in different technical replicates prepared separately on different days.

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PMC11088135

YAP1 is highly expressed in human glioma, and it may serve as a reliable prognostic biomarker and therapeutic target for glioma .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "YAP1", "is",...

PMC11562028

The size distribution of the Re-CDs was uniform, and concentrated in the 1–4 nm size range.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "size", "distribution", "of", "the", ...

PMC11733919

In the present study, we have designed a nanoplatform composed of iron oxide nanoparticles functionalized with an antibody against a cell surface marker of senescent cells (CD26), and loaded with the senolytic drug HSP90 inhibitor 17-DMAG (MNP@CD26@17D).

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PMC11350568

Designing a hyperefficient TMPDS. (

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Designing", "a", "hyperefficient", "TMPDS", ".", "(" ] } ]

PMC11345828

To address this, we envisioned replacing the 1,3,5-trimethylpyrazole with a symmetrical heteroaryl group and thereby removing the site of axial chirality.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "addres...

PMC10976516

However, the ultimate challenge for OV therapy is not only the eradication of locally injected tumor lesions but also all metastases, especially in advanced cancers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11365427

The phenylalanine-free diet contained all the same nutrients as the control diet, except for phenylalanine and corn starch.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "phenylalanine-free", "diet", ...

PMC9424261

Cancer is a major public problem in all countries of the world, and it is the leading cause of shortening lifespan and leading to death .

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PMC5916734

We previously developed plasmid vectors, p1.1 and p1.2, based on the untranslated regions of the translation elongation factor 1 alpha gene from Chinese hamster.

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PMC6364197

Importantly, we found that the molecular mechanisms of cell survival and drug resistance observed in the scaffold were similar to those reported in vivo.

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PMC9429973

A. Röth, W. Barcellini, S. D’Sa, Y. Miyakawa, C. M. Broome, M. Michel, D. J. Kuter, B. Jilma, T. H. A. Tvedt, I. C. Weitz, T. Sourdille, J. Wang, D. S. Vagge, K. Kralova, F. Shafer, M. Wardecki, M. Lee, S. Berentsen Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital E...

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PMC5673060

Dose response curve of PazR cells to pazopanib or NVP-AUY-922 treatment. (

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PMC9429973

Neither patient who received pomalidomide and dexamethasone or elotuzumab with lenalidomide and dexamethasone responded.

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PMC9429973

Infusion reactions occurred in 2 patients (13%), one of them experienced anaphylactoid reaction that required infusion interruption.

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PMC9429973

A gene editing platform using homology directed repair (HDR) that replaces the HBB gene to achieve a normal or β-thalassemia trait phenotype with HbA expression similar to healthy individuals is an ideal strategy.

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PMC11782508

EDX was employed to determine the elemental composition of the purified azurin (Fig. 5b).

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PMC10329237

Also, another study showed that LOS treatment significantly decreases migration in pancreatic stellate cells (50).

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PMC9960565

After freeze-drying, a light gray hygroscopic powder was obtained with a yield of 58% (0.13 g).

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PMC9429973

The absence of a resistance mutation influenced choice of therapy in another 4 patients.

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PMC11552389

12741, Cell Signaling Technology, Danvers, MA), rinsed, and probed for 30 minutes using secondary AF488-anti-mouse IgG (Invitrogen).

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PMC11521786

Considering the benefits of active immunotherapy and studies suggesting the antitumoral advantages of a polyclonal response over monoclonal antibodies (25–27), developing a vaccine against HER3 could be a strategy for treating cancers in which the activation of this receptor plays a fundamental role.

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PMC9351137

These subunits are structurally and functionally orthologous to human MRG15, Tip60, and CFDP1, respectively.

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PMC10291556

The full horizontal line indicates the level of phagocytosis of the untreated control cells.

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PMC10745221

Hyblot Cl) at -80°C for 63 days.

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PMC11591052

These data imply the activation of the PI3K/AKT/mTOR pathway.

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PMC10998613

These results support the interpretation that β2AR associates with CXCR4 multimers in this cancer cell line.

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PMC11679892

In this study, only the neuroblastoma cell line was examined, and no reference cell line was used.

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PMC10988555

The A2780 cell line was seeded in 25 cm T-flasks at a density of 2 × 10 cells/T-flasks.

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PMC11767793

Then, we discuss their qualification for positive and negative controls when applied in the in vitro cytotoxicity screening of MNMs in the context of previously defined requirements for such applications .

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PMC9429973

We applied Mass-Spectometry analysis of AML blasts and AML- or h-MSCs co-cultured for 21 days in 3D, finding a total of 15 differentially new synthesized secreted factors in the 3D medium of co-cultures with the AML blasts, related to inflammation, angiogenesis and cancer pathways.

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PMC11806106

Based on the Koff and the respective EC50 value, we calculated the on-rate Kon for each agonist.

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PMC11705901

Likely candidates would be by influencing the functional expression of other polymorphisms, and epigenetic processes such as methylation of the OXTR.

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PMC7917457

The B16.F10.9/K1 clone is considerably more responsive to cancer immunotherapies than the highly immunosuppressive parental strain B16.F10.9.

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PMC11317131

Next, we observed phage numbers plateau, likely due to the integrase variants reaching a point of hyperactivity that they were no longer challenged by the current level of stringency, necessitating increases in stringency for continued productive evolution.

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PMC11310713

The electrostatic extrusion method was used to produce GTB, as shown in the scheme.

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PMC11509309

CHO-K1 cells were treated with tunicamycin (Tm), an antibiotic that induces ER stress by inhibiting protein N-glycosylation , which triggers UPR and cell death.

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PMC11095939

Cholesterol is another important regulator of cell proliferation.

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PMC9429973

This inherited disorder causing hemolytic anemia, due to membrane proteins abnormalities.

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PMC11321678

Statistical analysis was performed by Prism 8 software or commercially available software (SPSS 22.0).

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PMC11773391

Cells were seeded in six‐well plates and grown to 70%–80% confluence; then, each well contained 5 × 10 cells and 5.0 μg MGMT‐Luc, according to the manufacturer's instructions for Lipofectamine 3000 (Thermo Fisher Scientific Inc.).

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PMC11694066

Data on the PARPi plus ATRi combination in DSRCT are much scarcer for now: one heavily pretreated patient, who received the PARPi olaparib in combination with ATRi AZD6738 as part of the eSMART trial (NCT02813135), presented stable disease for 4 months of the study (15).

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PMC11098378

These future studies will be important for understanding the impact of IpaH4-eukaryotic host interactions to bacterial replication and pathogenesis.

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PMC9429973

Summary/Conclusion: Our results demonstrated that Ulixertinib treatment reduced OPN production both in vitro and in vivo.

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PMC11637716

These included telomere length analysis, functional testing for Fanconi anaemia, followed by focused genetic testing for SAMD9, SAMD9L, GATA2 and RUNX1 mutations and then extended to a selection of genes involved in infantile myelodysplastic syndromes and BMF.

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PMC9268620

The foil was coated with a thin layer of cold in a sputter coater (Polaron E5100, SEM Coating Unit, Hertfordshire, UK).

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PMC11496491

A boxplot of the standardized strength values for each of the two sets of samples.

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PMC11525028

Then ITC assay was utilized to validate the interactions of both inhibitors with NAT10 (Figure 6D), and the titration curve showed that paliperidone (KD = 12.8 ± 8.72 μM) and AG-401 (KD = 1.92 ± 0.87 μM) could bound to NAT10 protein.

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PMC10154097

Decreased miR-218-5p might be a marker of bone metastasis in prostate cancer .

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PMC9429973

Moreover, both CD4+ and CD45RO+ markers, a characteristic immunophenotype of Sezary cells, represented subpopulations with a higher basic expression of TMEM244, suggesting the involvement of this gene in the disease onset.

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PMC11566417

Lysis was repeated, after which cells were washed once by centrifugation with PBS and resuspended in RPMI medium (Corning) + 1% HEPES (Thermo Fisher).

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PMC11748363

The latter compounds were advanced into testing against the virulent strain Mtb H37Rv, where they were found to preserve their antimycobacterial activity (MIC = 6.25 μg/mL), M. avium , and M. kansasii (Table 2).

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PMC8427838

Moesin is highly enriched at the sites of cellular protrusions such as filopodia, microvilli and microspikes, and has been proposed to positively regulate cell migration in different cell types .

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PMC11785489

After all, the TCR sequence is only one minor influence on the transcriptional state of a given T cell.

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PMC10006224

For the boxplot analysis in Supplementary Fig. 6e, signals for each protein and condition were obtained ±150-bp around peak summits and log2 fold change between NIPBL KD and control was calculated.

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PMC10698968

Graph shows single DTs (dots) calculated from exponential growth equations (example shown in C), with mean (lines).

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PMC10823017

The control group had 86% live cells along with only 2% cells with early apoptosis and 1.37% cells with late apoptosis.

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PMC9577200

Given the natural materials evaluation scenario as antibacterial and anticancer agents, the increase in antibiotic use has resulted in the emergence of antibiotic-resistant bacteria that have a dangerous impact on human health.

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PMC9429973

L. Largeaud, M. Collin, N. Monselet, F. Vergez, L. Larcher, P. Hirsch, N. Duployez, J. Bustamante, C. Bellanné-Chantelot, J. Donadieu, F. Sicre de Fontbrune, M. Nolla, C. Fieschi, F. Delhommeau, E. Delabesse, M. Pasquet Clinical Haematology laboratory, Toulouse Hospital; UMR1037, Cancer Research Center of Toulouse, Tou...

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PMC10850553

IA lesions (Aneurysm) or control arterial walls (Superficial temporal artery) were harvested subjected to immunohistochemical analyses.

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PMC11519583

Recent studies have shown that attenuated proliferation and adipogenic differentiation are representative phenotypes of MPs derived from aged mice .

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PMC11687167

Three isoforms of SREBP, SREBP1a, SREBP1c, and SREBP2, have been identified, each of which plays a different role in lipid synthesis.

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PMC11543885

Timing: 1–2 weeks Timing: 1–2 weeks Here we describe steps for the transfection and generation of a stable flag-NLRP3-APEX2 expression HEK293 cell line.16.Maintenance of Flp-In T-REx HEK293 cells.a.

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PMC11635519

This overlap is crucial for ensuring complete epitope presentation, including epitopes that span the boundaries between peptides.

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PMC2777936

To determine if stable repression of FZD5 or FZD7 in EC cells induced differentiation, expression of immunophenotypic differentiation-specific extracellular markers recognized by A2B5 and SSEA-3 were each examined.

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PMC9429973

CMML cases driven by mutations in RAS pathway signaling genes or ASXL1 have a higher risk of failure and progression to acute myeloid leukemia (AML).

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PMC11023271

Serum also contains extracellular DNA and RNA (for example microRNA), which may serve as the serum factor.

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PMC11391695

Following encapsulation of the pcDNA-ACYP2 vector within PEI/NPs, the NPs were coated with HCC cell membranes (pcDNA/PEI/NPs@M).

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PMC9436459

Of these compounds, 6, 31, 40, and 57 were found to be potent multi-targeted agents for AD.

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PMC11521786

Treated cell viability percentage was calculated using the following formula: cell viability (%) = (OD treated cell540–630 nm)/(OD nontreated cell540–630 nm) × 100.

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PMC11730000

mTOR protein expression levels were decreased in the DOX group compared with the control group (Figure 7A).

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PMC9429973

The fifth patient progressed within the first yr after ASCT and received VRD+dara.

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PMC8097906

The analysis of cell migration capacity under treatment with different concentrations of plant extracts (VSM and LW) and plant-derived compounds (Geni, Seco, Mata, Daid and Jaspl.)

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PMC9429973

Immunophenotypic analysis on the NK cell product was performed before and after the expansion.

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PMC10874773

Seco-prezizaane-type sesquiterpenes (SPS, Fig. 1A), as a class of sesquiterpenes, are known to be derived from bond cleavage in the backbone of prezizaanes (Li, Shen, & Zhang, 2016), which have a highly oxygenated fused tetra- or penta-cyclic structure with several continuous stereo centers (Kawamura et al., 2019), ori...

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PMC6379402

Also, we introduce a computational prototype of an iCell, which integrates three omics, tissue-specific molecular interaction network types.

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PMC9424261

TMT analysis was performed and analyzed by Luming Biotechnology (Shanghai, China).

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PMC9927933

The growth suppression by UBE2C knockdown could be largely rescued by simultaneous DEPTOR knockdown in lung cancer cells.

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PMC11476264

In the lung cancer database organized by Kaplan–Meier plot, analysis demonstrated that ZEB1 expression levels were negatively correlated with patient survival, and patients with high levels of FBXO11 expression in their tumors had higher overall survival rates and survived longer than patients with low levels of FBXO11...

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PMC8097906

However, established therapies often fail in advanced RMA and tumor relapse cases, rendering novel treatment strategies necessary .

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PMC7757104

Future work should evaluate their putative contribution to the resistant phenotype.

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PMC11758416

Wash adhered cells with at least 10 mL sterile 1X PBS.

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PMC9429973

We isolated CDK6-containing protein complexes by immunoprecipitation followed by mass spectrometry.

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