OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	≥10% Grade 1-2 AE included pruritus, fatigue, hypertension, and anemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "≥10", "%", "Grade", "1", "-", "2", "AE", "...
PMC10713411	Immune-related analyses in high- and low-PRPCDGs-risk groups in TCGA-KIRC cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immune-related", "analyses", "in", "high-", "and", "low-PRPCDGs-risk", "groups", "in", "TCGA-KIRC", ...
PMC10882807	magnification, 20x; scale bars, 200 μm), P < 0.05, p < 0.01, **p < 0.001 Despite advancements in this field , the survival rate of patients with HCC remains unsatisfactory due to challenges in early tumor diagnosis, as well as tumor recurrence and metastasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11089031	The ZNF692 transcript level was significantly increased (fold change = 3.02) in tumors compared with adjacent normal tissues (n = 72).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11739696	In many human cancers, there is a deregulation of this balance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "many", "human", "cancers", ",", "there", "is", "a", "deregulation", ...
PMC8358176	Over recent years, the focus of many research communities has been on nanomaterials such as fullerene derivatives, nanotubes, and nanowires that are used in the manufacture of biotechnological tools ( 4 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10968586	All these aspects may represent a potential source of difficulties if the objective is achieving and maintaining pharmacologically relevant concentrations of OLE and HT in plasma after ingestion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092382	Rehd et Wils.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Rehd", "et", "Wils", "." ] } ]
PMC11720808	Data are expressed as the mean ± SD (n=5). **	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "expressed", "as", "the", "mean", "±", "SD", "(", ...
PMC9429973	Results: Eight patients (pts) were enrolled into the first two cohorts; 7 received ≥ 1 dose of PegC and one dropped out before receiving study drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11665584	There were proportionally fewer IFE Suprabasal (Krt10, Serpinb3b), Upper HF Suprabasal (Cst6, Defb6), and HF Stem Cell 2 (Cd34, Tgm5) cells and more Lower HF 1 & 2 (Sox5, Ptch1; Lef, Pik3r3, respectively) PITX1 keratinocytes (Figure 7A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10706275	The cell lines K1-EGFP-8, K1-EGFP-21, and K1-EGFP-24, which were successfully adapted to suspension culture, underwent continuous passage for 60 generations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	The interaction between CHIP and epigenetic age acceleration was analysed using Cox proportional hazards regression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "interaction", "between", "CHIP", "and", "epigenetic", ...
PMC11377827	Remarkably, USP43 facilitates HIF-1 nuclear accumulation through hypoxia-sensitive recruitment of 14-3-3 proteins, rather than its deubiquitinase activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Remarka...
PMC11359735	10 pmoles of purified sVSG (native H6-myo-inositol) mixed with 10 pmoles of D6-myo-inositol internal standard was processed alongside as a standard.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "10", ...
PMC9479186	R2 > 0.25 was considered to have an interaction relationship.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "R2", ">", "0.25", "was", "considered", "to", "have", "an", "interaction", "relationship", ...
PMC11742670	The cells are then resuspended in 2 mL of 60% ice-cold ethanol and incubated at 4ºC for 1 h for fixation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells...
PMC11536589	The differences of discrete variables were compared using the Mann-Whitney test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "differences", "of", "discrete", "variables", "were", "compared", "using", "the", ...
PMC10654497	In addition, among non-small cell lung cancer patients, KEAP1 and STK11 mutated patients are not sensitive to immunotherapy and have shorter disease-free and overall survival (Fig. 4).Figure 4Comparison of somatic mutations and SFRGs between different subtypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743316	Indeed, new research has discovered that cancer cells may employ both glycolytic and oxidative processes to maintain the generation of ATP .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ","...
PMC11332076	Scale bar: 20 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "20", "μm", "." ] } ]
PMC9429973	D. Brandes, T. Brozou, S. Soura, A. Bergmann, U. Fischer, A. Borkhardt, R. Wagener Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany and University Hospital Duesseldorf; Duesseldorf School of Oncology (DSO), Duesseldorf; Institute of Human Genetics, H...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	With gentle stirring on ice, one-third volume of high-salt nuclear extraction buffer [20 mM Hepes (pH 7.9), 20 mM MgCl2, 1.2 M KCl, 1 mM DTT, 0.1 mM EDTA, 25% glycerol, and 1× Complete protease inhibitor cocktail] was added to the above suspension.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11621565	The transfer was made on a nitrocellulose membrane at 80V ct.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transfer", "was", "made", "on", "a", "nitrocellulose", "membrane", "at", ...
PMC11295144	Examples of three levels of IPSC frequency are shown as (i) high, >0.1 Hz, black; (ii) low, <0.1 Hz, gray; or (iii) no IPSCs, white. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5941560	Only Pindel calls with at least 2 supporting reads, a summed mapping score greater than or equal to 100, and a mean mapping score greater than 10 were kept for further analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11295144	In these experiments, the α2β2γ2-GABAAR/NL2- or α4β3δ-GABAAR/NL2-expressing HEK293 cells in co-culture with the medium spiny neurons were immunolabeled with an α2- or α4-subunit-specific antibody, respectively, in combination with a Bassoon-specific antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4369959	Administration of ginger extract to the mice pretreated with carcinogen 1,2-dimethylhydrazine (DMH) inhibited the levels of fecal bile acids, neutral sterols, tissue cholesterol, HMG CoA reductase, free fatty acids, triglycerides, phospholipase A, and phospholipase C .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8623816	Proteins encoded by dsRNA-1 shared the highest aa sequence identities to the RdRp of members of the family Partitiviridae.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteins", "encoded", "by", "dsRN...
PMC11552389	Overall, these analyses indicated that relative to normal skin, FOXN3 expression was significantly decreased in melanoma (Figure 1A and B, and Supplementary Figure 1), whereas FSIP1 expression was increased (Figure 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763126	Conclusion: These data indicate that CBDP1 exerts its antitumor effects by regulating the USP5/YTHDF2/TRPM3 axis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conclusion", ":", "These", "data", "indicate", "that",...
PMC11063646	Emulgels are widely used for delivering hydrophobic drugs (Patel et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Emulgels", "are", "widely", "used", "for", "delivering", "h...
PMC11803149	B-E) Violin plots show expression of exhaustion-related genes (Tox, Pdcd1, Lag3, Havcr2, and Tigit) (B), central memory-related genes (Sell and Ccr7) (C), a proliferation marker gene, Mki67 (D), and genes highly expressed specifically in cluster 0 (Shmt1, Shmt2, Phgdh, Mthfd1, C1qbp, and Eif5a) (E). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379	For identification of key genes involved in the transition from adherent to suspension morphology, expression data from an additional set of 63 different human cell lines deposited in the Human Protein Atlas database were analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10577955	These results agree with those of Zhan et al., 2018 who reported that treating paclitaxel-resistant lung cancer cells (H460) with betulinic acid induced a G2/M phase cell cycle arrest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC11486946	Representative images from 11 independent experiments are displayed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "from", "11", "independent", "experiments", "are", "displayed", "." ] } ]
PMC11489275	All Statistical analyses were performed using IBM SPSS Statistics (Version 26.0) and R Studio (Version 3.6.3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "Statistical", "analys...
PMC11754432	Yet, ALOX15B expression has been observed in the basal and spinous layers of the epidermis of non-lesional skin by in situ hybridisation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yet", ...
PMC11509309	The filtered extracts were combined and dried under reduced pressure, which produced a brown residue (13.43 g) that was partitioned between CH2Cl2 and H2O.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10040136	The P-value indicates significant difference between the two survival curves. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "P-value", "indicates", "significant", "difference", "between", "the", "two", "surviv...
PMC7136814	Interestingly, we found MYOD1 to be expressed in approximately 5 to 25% of RD cells and 1 to 10% of A-204 cells, while the majority of cells (≥80%) had MYOD1 below detection levels (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "...
PMC9429973	MRD by NGS was assessed from BM aspirates by the clonoSEQ® assay (Adaptive Biotechnologies) with a limit of detection <10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11655536	Tumor volumes and mice body weights were examined every other day (Fig. 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor", "volumes", "and", "mice", "body", "weights", "were"...
PMC11731161	A–D NCI-H929 and MM.1S cells were transfected with the tet-on-shRNA either with control sequence (NC) or sequences targeting USP7 (#1 and #2), cells were treated with 1ug/ml DOX for 48 h, USP7 (A and B) and XPO1 (A and C) protein levels were analyzed by immunoblotting and were quantitatively analyzed.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11684821	Strikingly, most of the MC.7.G5-like T cells we describe incorporated a conserved CAXYGGSQGNLIF amino acid motif, where X represents 3–5 amino acids, in their unusually long CDR3-α.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Overall survival at 1 year was 100% in the 3mg KRP203+CsA, 67% in the 1mg KRP203+CsA and 36% in the 3mg KRP203+Tac arm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11687663	In this case, the IC50 values are given in μg/mL, indicating the concentration at which each substance is able to inhibit the growth of HepG2 cells by 50% .This screening was conducted to validate the in-silico molecular docking results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	GFP signals were then divided by the percent area of RFP to give normalized GFP signal.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GFP", "signals", "were", "then", "divided", "by", ...
PMC11594588	This disrupts most of the key metabolic processes occurring in cardiomyocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "disrupts", "most", "of", "the", "key", "metabolic", "processes", "occurring", ...
PMC11225860	The ploidy classification performed by QuPath highlights normalploid cells in green and polyploid cells in blue (C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ploidy", "classification", ...
PMC8494202	P values < 0.05 were considered statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "values", "<", "0.05", "were", "considered", "statistically", "significant", "." ] } ]
PMC6034753	The GST pull-down showed that Meq interacts with GST-Apoptin and Apoptin interacts with GST-Meq (1–170).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "GST", "pull-down", "showed", "that", ...
PMC9587298	The cytotoxic effect of different concentrations of MGO (0 – 5.0 mM) was evaluated for 24 h and 48 h exposure, as shown in Fig. 6a.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	None of the TEAEs were severe, and no participants discontinued treatment due to TEAEs; there were no serious adverse events or deaths.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11267830	The supernatant was collected for subsequent analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "supernatant", "was", "collected", "for", "subsequent", "analysis", "." ] } ]
PMC11173119	Fifty cells positively stained for CD14 marker were analyzed for each healthy and FMF patient iPSCs-derived macrophages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fifty", "cells", "positively", "stained", "for", ...
PMC11286266	Actin was used as a loading control marker. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Actin", "was", "used", "as", "a", "loading", "control", "marker", ".", "(" ] } ]
PMC8711270	C6 cells did not result in the generation of replication competent viruses, allowing for the cost-effect production of AdV vectors.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C6", "cells", ...
PMC10048572	Some of these mutations are driver ones that impact the therapy choice and the outcome of the disease, some may simply serve as markers of a tumor clone .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	There was no association with % circulating IMC, monocytes, WBC or ANC at baseline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "no", "association", "with", "%", ...
PMC9325715	Thus, such structures may also form in Fe-bLTF complexes as all transferrins have highly homologous structures and reveal similar properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "such...
PMC11658074	AT is primarily composed of lipid-rich cells known as adipocytes, along with stromal vascular fraction cells (SVFs) that consist of adipose-derived stem cells (ADSCs), preadipocytes, endothelial cells, and immune cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11443022	Treatment strategies included attempted varicocelectomy, pharmacological intervention with amoxapine, and surgical testicular sperm extraction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "strategies", "included", "attempted", "varicoce...
PMC9429973	Further assessing clinical outcomes in CLL+AF vs CLL-AF, significantly higher incidence of HF (26.3% vs 3.0%; P < .001), bleeding (12.2% vs 4.8%; P < .001) and stroke (6.6% vs 1.2%; P < .001) were observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	Cancer-associated fibroblasts (CAFs) found frequently in tumor microenvironment have a definite function in tumor development and drug efficacy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer-associated", "fibroblasts",...
PMC10048572	ITH-based studies with prognostic information available were included.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ITH-based", "studies", "with", "prognostic", "information", "available", "were", "included", "." ] } ]
PMC9847912	The sequence for p7312A was provided by the laboratory of George Shaw via Fred Bibollet-Ruche University of Pennsylvania, Philadelphia, PA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "seque...
PMC9429973	In 9 cases type of insert was not detected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "9", "cases", "type", "of", "insert", "was", "not", "detected", "." ] } ]
PMC9848491	Data from the International Federation of Obstetricians and Gynaecologists show a significant decline in survival in patients with advanced UCEC and metastatic endometrial cancer (3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11658074	a The protein expression of CD151 in AT-EVs and ADSC-EVs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "The", "protein", "expression", "of", "CD151", "in", "AT-EVs", "and", "ADSC-EVs", "." ...
PMC7192625	Further work on higher resolution capture Hi-C networks could shed further light on the biological meaning of these results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "work", "on", "higher",...
PMC9429973	FFP is used by both medical and surgical specialties with general surgery, general medicine and neurosurgery being the main users.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FFP", "is", "used...
PMC11585565	The results are from four independent experiments (n = 4). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "are", "from", "four", "independent", "experiments", "(", ...
PMC9429973	In total, 33 previously unknown genetic alterations were identified by OGM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "total", ",", "33", "previously", "unknown", "genetic", "alterations", "wer...
PMC11707577	Engineered living materials (ELM) focuses on novel hybrid materials derived from combination of artificial and biological components, presenting the hallmarks of material from nature, from biocompatibility to targeting, adaptation, longevity and sustainability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11507371	The aforementioned concept of redox adaptation introduced by Kong et al. further elaborates that while the strengthening of defence mechanisms manages to maintain a balance between the harmful effects of ROS and the protective role of antioxidants at a basic level, it fails to react to further increasing ROS levels, es...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9368503	Synovial sarcoma is a rare translocation-driven cancer with poor survival outcomes, particularly in the advanced setting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Synovial", "sarcoma", "is", "a", "rare", "t...
PMC9027909	The intestinal barrier plays crucial role in keeping homeostasis of the gut and protecting from translocation of the gut contents into the lower layers, such as mucus and the circulation system .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8973725	Dysregulation of gene methylation has been shown to increase ccRCC cell proliferation and invasion and may contribute to the progression and recurrence of ccRCC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11344246	Given each of our candidate genes have roles within the cell cycle, cell cycle analysis was completed using total intensity of DAPI staining to infer DNA content in knockdown and control cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10523483	Here, we identify an H1.2–NRF2 antioxidant feedforward cycle that promotes NSCLC progression and confers resistance to chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "identify", "an", ...
PMC9429973	Likewise, we found that ATAD2 is up-regulated in T-ALL patients and associated with poor prognosis and cell cycle pathway abnormal activation (P<0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11741577	HaCaT cells (2×10) were seeded in the upper chamber with DMEM (50 μl) containing 2% FBS, and treated with 50 μl of CM or serum-free IMDM.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11474209	However, when additional extremely abundant but less harmful homologs are present, it is challenging to discriminate between the structurally identical MC homologs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11320834	Durvalumab is a human immunoglobulin G1 kappa monoclonal antibody that blocks the interaction of PD-L1 with PD-1 and CD80.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Durvalumab", "is", "a", "human", ...
PMC11434983	The cell suspensions were transferred to scintillation vials, cell-associated radioactivity was measured using an automated gamma counter, and the percentage of cell-bound radioactivity was calculated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11597291	The 4-arm PEG(10 kDa)-NH2 exhibited a PCT loading capacity of 33 %wt, lower than the 52 %wt loading of the linear PEG(10 kDa)-NH2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	P. Pölönen, A. Elsayed, L. Montefiori, S. Kimura, J. Myers, D. Hedges, J. Xu, Y. Hui, Z. Cheng, Y. Fan, Y. Chang, R. Shraim, M. Devidas, S. Winter, K. Dunsmore, J. J. Yang, T. L. Vincent, K. Tan, C. Chen, H. Newman, M. Loh, E. Raetz, S. P. Hunger, E. Rampersaud, T.-C. Chang, G. Wu, S. Pounds, C. G. Mullighan, D. T. Tea...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10998613	PIE-FCCS measurements were performed as previously described (34).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PIE-FCCS", "measurements", "were", "performed", "as", "previously", "described", "(", "34", ")",...
PMC11301242	The counts of transcript fusions were compared between samples containing circular amplicons and those lacking circular amplicons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "counts", "of", "transcript", "fusions", ...
PMC9429973	Additional mutations are defined as pathogenic mutations in any non-driver gene from the myeloid panel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "mutations", "are", "defined", "as", "pathogenic", ...
PMC9429973	An anti-S IgG response was observed in 81.1% (30/37) of MPN patients after a first dose, increasing after two doses to 91.7% (55/60).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11201245	Kim et al. (2007) have already shown genomic increases in 8q24 in serous OC, although these were located more distally in a gene-rich region in 8q24.3 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8839885	After 24 h, cells were treated with platinum chemotherapy, consisting of 5 μM of our synthesized platinum (IV) prodrug (RJY13) in combination with 10 μM of 2-methoxyestradiol (2ME2) and endogenous metabolite of 17β-estradiol, 2-hydroxyestradiol (2HE2) , imatinib , ceritinib , BAY-61-3606 , tyrphostin AG-1296 , PD98059 ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11322866	We speculate that the increase in Lamin B1 level is involved in the senescence of MM cells induced by EZH2 inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "speculate", ...
PMC10142392	Therefore, this elucidation of the contributions of the hydrophobicity of block copolymers during self-assembly can provide new perspectives and powerful strategies for programming the morphology and dimensions of block copolymer aggregates in solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11025866	A small upregulation of SLC7A11 occurred in EBV-negative 293 cells exogenously expressing the EBV lytic transactivator protein RTA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "small", "upregulation", "of", ...
PMC11407042	Add 50 μL CytoTox 96 Reagent to each well and incubate for 30 min at room temperature in the dark.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Add", "50", "μL", "Cyt...
PMC9429973	Anticoagulants are deemed high risk medications due to their narrow therapeutic index, and the risk of significant adverse patient outcomes that can occur due to over or under dosing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301242	Discordant read pair clusters are shown as arcs, with the colors indicating the orientation of the reads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Discordant", "read", "pair", "clusters", ...

PMC9429973

≥10% Grade 1-2 AE included pruritus, fatigue, hypertension, and anemia.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "≥10", "%", "Grade", "1", "-", "2", "AE", "...

PMC10713411

Immune-related analyses in high- and low-PRPCDGs-risk groups in TCGA-KIRC cohort.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immune-related", "analyses", "in", "high-", "and", "low-PRPCDGs-risk", "groups", "in", "TCGA-KIRC", ...

PMC10882807

magnification, 20x; scale bars, 200 μm), *P < 0.05, **p < 0.01, ***p < 0.001 Despite advancements in this field , the survival rate of patients with HCC remains unsatisfactory due to challenges in early tumor diagnosis, as well as tumor recurrence and metastasis .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11089031

The ZNF692 transcript level was significantly increased (fold change = 3.02) in tumors compared with adjacent normal tissues (n = 72).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11739696

In many human cancers, there is a deregulation of this balance.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "many", "human", "cancers", ",", "there", "is", "a", "deregulation", ...

PMC8358176

Over recent years, the focus of many research communities has been on nanomaterials such as fullerene derivatives, nanotubes, and nanowires that are used in the manufacture of biotechnological tools ( 4 ).

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PMC10968586

All these aspects may represent a potential source of difficulties if the objective is achieving and maintaining pharmacologically relevant concentrations of OLE and HT in plasma after ingestion.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11092382

Rehd et Wils.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Rehd", "et", "Wils", "." ] } ]

PMC11720808

Data are expressed as the mean ± SD (n=5). **

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "expressed", "as", "the", "mean", "±", "SD", "(", ...

PMC9429973

Results: Eight patients (pts) were enrolled into the first two cohorts; 7 received ≥ 1 dose of PegC and one dropped out before receiving study drugs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11665584

There were proportionally fewer IFE Suprabasal (Krt10, Serpinb3b), Upper HF Suprabasal (Cst6, Defb6), and HF Stem Cell 2 (Cd34, Tgm5) cells and more Lower HF 1 & 2 (Sox5, Ptch1; Lef, Pik3r3, respectively) PITX1 keratinocytes (Figure 7A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10706275

The cell lines K1-EGFP-8, K1-EGFP-21, and K1-EGFP-24, which were successfully adapted to suspension culture, underwent continuous passage for 60 generations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

The interaction between CHIP and epigenetic age acceleration was analysed using Cox proportional hazards regression.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "interaction", "between", "CHIP", "and", "epigenetic", ...

PMC11377827

Remarkably, USP43 facilitates HIF-1 nuclear accumulation through hypoxia-sensitive recruitment of 14-3-3 proteins, rather than its deubiquitinase activity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Remarka...

PMC11359735

10 pmoles of purified sVSG (native H6-myo-inositol) mixed with 10 pmoles of D6-myo-inositol internal standard was processed alongside as a standard.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "10", ...

PMC9479186

R2 > 0.25 was considered to have an interaction relationship.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "R2", ">", "0.25", "was", "considered", "to", "have", "an", "interaction", "relationship", ...

PMC11742670

The cells are then resuspended in 2 mL of 60% ice-cold ethanol and incubated at 4ºC for 1 h for fixation.

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PMC11536589

The differences of discrete variables were compared using the Mann-Whitney test.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "differences", "of", "discrete", "variables", "were", "compared", "using", "the", ...

PMC10654497

In addition, among non-small cell lung cancer patients, KEAP1 and STK11 mutated patients are not sensitive to immunotherapy and have shorter disease-free and overall survival (Fig. 4).Figure 4Comparison of somatic mutations and SFRGs between different subtypes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11743316

Indeed, new research has discovered that cancer cells may employ both glycolytic and oxidative processes to maintain the generation of ATP .

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PMC11332076

Scale bar: 20 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "20", "μm", "." ] } ]

PMC9429973

D. Brandes, T. Brozou, S. Soura, A. Bergmann, U. Fischer, A. Borkhardt, R. Wagener Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany and University Hospital Duesseldorf; Duesseldorf School of Oncology (DSO), Duesseldorf; Institute of Human Genetics, H...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11721587

With gentle stirring on ice, one-third volume of high-salt nuclear extraction buffer [20 mM Hepes (pH 7.9), 20 mM MgCl2, 1.2 M KCl, 1 mM DTT, 0.1 mM EDTA, 25% glycerol, and 1× Complete protease inhibitor cocktail] was added to the above suspension.

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PMC11621565

The transfer was made on a nitrocellulose membrane at 80V ct.,

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PMC11295144

Examples of three levels of IPSC frequency are shown as (i) high, >0.1 Hz, black; (ii) low, <0.1 Hz, gray; or (iii) no IPSCs, white. (

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PMC5941560

Only Pindel calls with at least 2 supporting reads, a summed mapping score greater than or equal to 100, and a mean mapping score greater than 10 were kept for further analysis.

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PMC11295144

In these experiments, the α2β2γ2-GABAAR/NL2- or α4β3δ-GABAAR/NL2-expressing HEK293 cells in co-culture with the medium spiny neurons were immunolabeled with an α2- or α4-subunit-specific antibody, respectively, in combination with a Bassoon-specific antibody.

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PMC4369959

Administration of ginger extract to the mice pretreated with carcinogen 1,2-dimethylhydrazine (DMH) inhibited the levels of fecal bile acids, neutral sterols, tissue cholesterol, HMG CoA reductase, free fatty acids, triglycerides, phospholipase A, and phospholipase C .

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PMC8623816

Proteins encoded by dsRNA-1 shared the highest aa sequence identities to the RdRp of members of the family Partitiviridae.

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PMC11552389

Overall, these analyses indicated that relative to normal skin, FOXN3 expression was significantly decreased in melanoma (Figure 1A and B, and Supplementary Figure 1), whereas FSIP1 expression was increased (Figure 1C).

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PMC11763126

Conclusion: These data indicate that CBDP1 exerts its antitumor effects by regulating the USP5/YTHDF2/TRPM3 axis.

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PMC11063646

Emulgels are widely used for delivering hydrophobic drugs (Patel et al., 2021).

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PMC11803149

B-E) Violin plots show expression of exhaustion-related genes (Tox, Pdcd1, Lag3, Havcr2, and Tigit) (B), central memory-related genes (Sell and Ccr7) (C), a proliferation marker gene, Mki67 (D), and genes highly expressed specifically in cluster 0 (Shmt1, Shmt2, Phgdh, Mthfd1, C1qbp, and Eif5a) (E). (

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PMC7642379

For identification of key genes involved in the transition from adherent to suspension morphology, expression data from an additional set of 63 different human cell lines deposited in the Human Protein Atlas database were analyzed.

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PMC10577955

These results agree with those of Zhan et al., 2018 who reported that treating paclitaxel-resistant lung cancer cells (H460) with betulinic acid induced a G2/M phase cell cycle arrest.

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PMC11486946

Representative images from 11 independent experiments are displayed.

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PMC11489275

All Statistical analyses were performed using IBM SPSS Statistics (Version 26.0) and R Studio (Version 3.6.3).

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PMC11754432

Yet, ALOX15B expression has been observed in the basal and spinous layers of the epidermis of non-lesional skin by in situ hybridisation.

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PMC11509309

The filtered extracts were combined and dried under reduced pressure, which produced a brown residue (13.43 g) that was partitioned between CH2Cl2 and H2O.

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PMC10040136

The P-value indicates significant difference between the two survival curves. (

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PMC7136814

Interestingly, we found MYOD1 to be expressed in approximately 5 to 25% of RD cells and 1 to 10% of A-204 cells, while the majority of cells (≥80%) had MYOD1 below detection levels (Table 1).

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PMC9429973

MRD by NGS was assessed from BM aspirates by the clonoSEQ® assay (Adaptive Biotechnologies) with a limit of detection <10.

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PMC11655536

Tumor volumes and mice body weights were examined every other day (Fig. 5A).

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PMC11731161

A–D NCI-H929 and MM.1S cells were transfected with the tet-on-shRNA either with control sequence (NC) or sequences targeting USP7 (#1 and #2), cells were treated with 1ug/ml DOX for 48 h, USP7 (A and B) and XPO1 (A and C) protein levels were analyzed by immunoblotting and were quantitatively analyzed.

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PMC11684821

Strikingly, most of the MC.7.G5-like T cells we describe incorporated a conserved CAXYGGSQGNLIF amino acid motif, where X represents 3–5 amino acids, in their unusually long CDR3-α.

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PMC9429973

Overall survival at 1 year was 100% in the 3mg KRP203+CsA, 67% in the 1mg KRP203+CsA and 36% in the 3mg KRP203+Tac arm.

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PMC11687663

In this case, the IC50 values are given in μg/mL, indicating the concentration at which each substance is able to inhibit the growth of HepG2 cells by 50% .This screening was conducted to validate the in-silico molecular docking results.

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PMC11098378

GFP signals were then divided by the percent area of RFP to give normalized GFP signal.

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PMC11594588

This disrupts most of the key metabolic processes occurring in cardiomyocytes.

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PMC11225860

The ploidy classification performed by QuPath highlights normalploid cells in green and polyploid cells in blue (C).

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PMC8494202

P values < 0.05 were considered statistically significant.

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PMC6034753

The GST pull-down showed that Meq interacts with GST-Apoptin and Apoptin interacts with GST-Meq (1–170).

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PMC9587298

The cytotoxic effect of different concentrations of MGO (0 – 5.0 mM) was evaluated for 24 h and 48 h exposure, as shown in Fig. 6a.

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PMC9429973

None of the TEAEs were severe, and no participants discontinued treatment due to TEAEs; there were no serious adverse events or deaths.

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PMC11267830

The supernatant was collected for subsequent analysis.

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PMC11173119

Fifty cells positively stained for CD14 marker were analyzed for each healthy and FMF patient iPSCs-derived macrophages.

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PMC11286266

Actin was used as a loading control marker. (

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PMC8711270

C6 cells did not result in the generation of replication competent viruses, allowing for the cost-effect production of AdV vectors.

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PMC10048572

Some of these mutations are driver ones that impact the therapy choice and the outcome of the disease, some may simply serve as markers of a tumor clone .

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PMC9429973

There was no association with % circulating IMC, monocytes, WBC or ANC at baseline.

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PMC9325715

Thus, such structures may also form in Fe-bLTF complexes as all transferrins have highly homologous structures and reveal similar properties.

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PMC11658074

AT is primarily composed of lipid-rich cells known as adipocytes, along with stromal vascular fraction cells (SVFs) that consist of adipose-derived stem cells (ADSCs), preadipocytes, endothelial cells, and immune cells.

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PMC11443022

Treatment strategies included attempted varicocelectomy, pharmacological intervention with amoxapine, and surgical testicular sperm extraction.

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PMC9429973

Further assessing clinical outcomes in CLL+AF vs CLL-AF, significantly higher incidence of HF (26.3% vs 3.0%; P < .001), bleeding (12.2% vs 4.8%; P < .001) and stroke (6.6% vs 1.2%; P < .001) were observed.

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PMC7823217

Cancer-associated fibroblasts (CAFs) found frequently in tumor microenvironment have a definite function in tumor development and drug efficacy .

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PMC10048572

ITH-based studies with prognostic information available were included.

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PMC9847912

The sequence for p7312A was provided by the laboratory of George Shaw via Fred Bibollet-Ruche University of Pennsylvania, Philadelphia, PA.

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PMC9429973

In 9 cases type of insert was not detected.

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PMC9848491

Data from the International Federation of Obstetricians and Gynaecologists show a significant decline in survival in patients with advanced UCEC and metastatic endometrial cancer (3).

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PMC11658074

a The protein expression of CD151 in AT-EVs and ADSC-EVs.

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PMC7192625

Further work on higher resolution capture Hi-C networks could shed further light on the biological meaning of these results.

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PMC9429973

FFP is used by both medical and surgical specialties with general surgery, general medicine and neurosurgery being the main users.

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PMC11585565

The results are from four independent experiments (n = 4). (

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PMC9429973

In total, 33 previously unknown genetic alterations were identified by OGM.

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PMC11707577

Engineered living materials (ELM) focuses on novel hybrid materials derived from combination of artificial and biological components, presenting the hallmarks of material from nature, from biocompatibility to targeting, adaptation, longevity and sustainability.

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PMC11507371

The aforementioned concept of redox adaptation introduced by Kong et al. further elaborates that while the strengthening of defence mechanisms manages to maintain a balance between the harmful effects of ROS and the protective role of antioxidants at a basic level, it fails to react to further increasing ROS levels, es...

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PMC9368503

Synovial sarcoma is a rare translocation-driven cancer with poor survival outcomes, particularly in the advanced setting.

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PMC9027909

The intestinal barrier plays crucial role in keeping homeostasis of the gut and protecting from translocation of the gut contents into the lower layers, such as mucus and the circulation system .

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PMC8973725

Dysregulation of gene methylation has been shown to increase ccRCC cell proliferation and invasion and may contribute to the progression and recurrence of ccRCC .

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PMC11344246

Given each of our candidate genes have roles within the cell cycle, cell cycle analysis was completed using total intensity of DAPI staining to infer DNA content in knockdown and control cells.

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PMC10523483

Here, we identify an H1.2–NRF2 antioxidant feedforward cycle that promotes NSCLC progression and confers resistance to chemotherapy.

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PMC9429973

Likewise, we found that ATAD2 is up-regulated in T-ALL patients and associated with poor prognosis and cell cycle pathway abnormal activation (P<0.001).

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PMC11741577

HaCaT cells (2×10) were seeded in the upper chamber with DMEM (50 μl) containing 2% FBS, and treated with 50 μl of CM or serum-free IMDM.

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PMC11474209

However, when additional extremely abundant but less harmful homologs are present, it is challenging to discriminate between the structurally identical MC homologs.

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PMC11320834

Durvalumab is a human immunoglobulin G1 kappa monoclonal antibody that blocks the interaction of PD-L1 with PD-1 and CD80.

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PMC11434983

The cell suspensions were transferred to scintillation vials, cell-associated radioactivity was measured using an automated gamma counter, and the percentage of cell-bound radioactivity was calculated.

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PMC11597291

The 4-arm PEG(10 kDa)-NH2 exhibited a PCT loading capacity of 33 %wt, lower than the 52 %wt loading of the linear PEG(10 kDa)-NH2.

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PMC9429973

P. Pölönen, A. Elsayed, L. Montefiori, S. Kimura, J. Myers, D. Hedges, J. Xu, Y. Hui, Z. Cheng, Y. Fan, Y. Chang, R. Shraim, M. Devidas, S. Winter, K. Dunsmore, J. J. Yang, T. L. Vincent, K. Tan, C. Chen, H. Newman, M. Loh, E. Raetz, S. P. Hunger, E. Rampersaud, T.-C. Chang, G. Wu, S. Pounds, C. G. Mullighan, D. T. Tea...

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PMC10998613

PIE-FCCS measurements were performed as previously described (34).

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PMC11301242

The counts of transcript fusions were compared between samples containing circular amplicons and those lacking circular amplicons.

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PMC9429973

Additional mutations are defined as pathogenic mutations in any non-driver gene from the myeloid panel.

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PMC9429973

An anti-S IgG response was observed in 81.1% (30/37) of MPN patients after a first dose, increasing after two doses to 91.7% (55/60).

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PMC11201245

Kim et al. (2007) have already shown genomic increases in 8q24 in serous OC, although these were located more distally in a gene-rich region in 8q24.3 .

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PMC8839885

After 24 h, cells were treated with platinum chemotherapy, consisting of 5 μM of our synthesized platinum (IV) prodrug (RJY13) in combination with 10 μM of 2-methoxyestradiol (2ME2) and endogenous metabolite of 17β-estradiol, 2-hydroxyestradiol (2HE2) , imatinib , ceritinib , BAY-61-3606 , tyrphostin AG-1296 , PD98059 ...

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PMC11322866

We speculate that the increase in Lamin B1 level is involved in the senescence of MM cells induced by EZH2 inhibition.

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PMC10142392

Therefore, this elucidation of the contributions of the hydrophobicity of block copolymers during self-assembly can provide new perspectives and powerful strategies for programming the morphology and dimensions of block copolymer aggregates in solution.

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PMC11025866

A small upregulation of SLC7A11 occurred in EBV-negative 293 cells exogenously expressing the EBV lytic transactivator protein RTA .

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PMC11407042

Add 50 μL CytoTox 96 Reagent to each well and incubate for 30 min at room temperature in the dark.

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PMC9429973

Anticoagulants are deemed high risk medications due to their narrow therapeutic index, and the risk of significant adverse patient outcomes that can occur due to over or under dosing.

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PMC11301242

Discordant read pair clusters are shown as arcs, with the colors indicating the orientation of the reads.

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