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PMC11298021
Studies have shown that rapamycin can induce cell cycle arrest and apoptosis in T-ALL cells by inhibiting downstream effectors of the PI3K/Akt/mTOR pathway, including p70S6 kinase and 4E-BP1.
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PMC11697189
We found differences in the tumor microenvironment of renal cancer patients in different risk groups, which may be one of the reasons affecting the prognosis of the two groups.
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PMC9429973
Methods: We generated HPC cell lines from high-purity sorted murine LSK cells by Lhx2 overexpression.
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PMC11506670
To evaluate the effects of the identified single amino acid mutations on protein structure, models for NRAS G48C, Q43K, and E37K were generated using SWISS-MODEL (accessed through https://swissmodel.expasy.org (accessed on 12 July 2024)).
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PMC11789597
Tumor size was calculated at the indicated time points using the following standard formula: Volume = (length × width)/2.
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PMC10142392
Despite this, comparative analysis of the properties of linear block copolymers and star compositions is important as it can help determine which structure is best suited for a specific application.
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PMC9952933
The current study shows the effect of CAP not only on osteosarcoma cells but also on Ewing’s sarcoma cells in direct comparison to the effect on non-malignant bone cells.
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PMC11365983
Skeletal phenotypes present in the cohort of patients with FOXC1 mutation or copy number variation include scoliosis and pre-axial polydactyly (arrowhead); the duplicated second phalanx of the left thumb was previously surgically removed.
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PMC11683130
The reduction of SerpinA12 leads to an overactivation of KLK7 and thus an excessive loss of corneocytes, which impair epidermal barrier.
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PMC11791203
All the cultures were incubated at 37°C in a humidified environment with 5% CO2.
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PMC9429973
Results: Our analysis indicated increased methylation at the SLIT2 promoter site in AML patients compared to healthy CD34.
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PMC11779993
The absorbance was measured at 734 nm using a microplate reader (Synergy H, Bio-tex, VT, USA).
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PMC11585565
This graphic summarizes the key findings of this study, illustrating that the missense variants c.1474G > T, c.1475G > A, and c.1484 C > T in CNNM4, which correspond to p.(Gly492Cys), p.(Gly492Asp), and p.(Thr495Ile), respectively, in the CBS domain of the CNNM4 protein, result in significantly increased mRNA and prote...
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PMC11790599
Unraveling the precise molecular targets is crucial for understanding the selectivity of TSL’s action towards these specific subtypes of breast cancer cells and distinguishing why it does not exert similar effects on other cell types.
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PMC9429973
Animals were treated for 6 weeks with epeleuton 1,000 mg/kg once daily or vehicle by gavage.
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PMC8345486
The structure of the A2780cis spheroids was loose, resembling an aggregate conformation.
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PMC9429973
Aims: Here we describe the study design of a Phase Ib/II study to assess the safety and efficacy of the novel combination of siremadlin + venetoclax + azacitidine in patients with AML who are unfit for IC (NCT05155709).
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PMC8358006
As expected, we found that TBX20 depletion significantly suppressed cell growth in vitro (Fig. 5d) and in vivo (Fig. 5e, Supplementary Fig. 12).Fig.
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PMC9428827
Here we demonstrate that mutein can change the CD8MP/Treg balance in vivo in both healthy and tumor-bearing mice.
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PMC10874773
When there is present a 13,14-β-lactone, most of the neurotoxic compounds show no toxicity and neurotrophic activity after β-lactone ring opening.
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PMC11767725
Metabolic disorders, including T2DM, obesity, and MetS, are characterized by intricate interactions among genetic predispositions, environmental exposures, and lifestyle habits.
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PMC9429973
The most used ESA was darbepoetin alfa (60%), followed by epoetin alfa (38%) and epoetin alfa-epbx (2%).
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PMC10907726
To validate these findings, we found that qRT-PCR results was consistent with the results of Western blot analysis.
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PMC11588085
In two independent ovarian cancer cell lines, knocking down XIST led to enrichment of the M-CSC subtype of CSCs.
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PMC11627133
Its ligand was further optimized, yielding the fluorogenic spirocyclic rhodamine SpyRho.
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PMC11575040
In summary, LINC00094 knockdown inhibited the growth of melanoma cells by inhibiting the PI3K/AKT signaling pathway, thereby hindering cell cycle progression and inducing apoptosis.
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PMC10114490
Minor changes in specific cellular pathways might be overseen in a global expression profile analysis.
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PMC11754432
Given that epidermal differentiation is mediated through a Ca gradient, membrane localisation of ALOX15B in the stratum granulosum detected in Fig. 1 aligns with this.
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PMC8414691
F Multinucleated cells (MC).
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PMC11267830
Our study revealed that indisulam, which targets RBM39 to induce tumor cell apoptosis, is an effective drug for treating T-ALL.
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PMC11787355
Briefly, 9-mer peptides of human proteome that share at least 5 amino acids with the target epitope were shortlisted.
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PMC9429973
Only newly emerged ICD-10-GM coding’s were assessed as being potentially treatment related.
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PMC9429973
Aims: In this randomized phase II trial we evaluated the impact of either Revlimid (R) or Thalidomide (T) as combination partner for K and dexamethasone (KRd or KTd) on outcome in pts with newly diagnosed MM (NDMM) not eligible for autologous transplantation (TNE).
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PMC11640476
Fibrinogen solution was further diluted in complete DMEM (10% FBS) to a final concentration of 2.5 mg/mL before use (fibrinogen WS).
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PMC11488203
Whereas SDF-1 represents the ligand for the chemokine receptors CXCR4 and CXCR7, Western blot analyses were performed to identify expression of these receptors on the different cancer cell lines representing five different tumor entities.
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PMC11745600
B, Gross image of a kidney transplanted with porcine pancreatic islets.
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PMC9429973
Pts in Cohort B who achieve stable disease and derive clinical benefit, per the treating physician, may continue to receive an additional 3 cycles of Lonca-R. All pts will be followed every 12 weeks for 1 year, then every 24 weeks for up to 3 years, and then annually up to 5 years.
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PMC9429973
Around 17 million deaths occur worldwide due to cancer annually and blood coagulation, specifically thrombin, has been shown to play an important role.
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PMC9429973
Using different proportions of transformation-positive MM cells spiked with transformation-negative leukemic cells, HL-60, ISM-FISH showed a sensitivity of less than 0.1%.
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PMC11387401
Only one study, by Bouwman et al, (2014), also examined its interaction with other cellular RNAs by performing Tat CLIP coupled with microarray analysis, reporting 317 Tat-mRNA interactions (Bouwman et al, 2014).
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PMC11803918
The tumor-targeting capability of γδ-T exosomes makes them effective vehicles for delivering therapeutic agents directly to the tumor site, improving treatment efficacy, and reducing off-target effects.
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PMC11628309
Use of the BE (2)-M17 cell line in research.
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PMC11509309
The pro-apoptotic factor CHOP is a marker of UPR induction .
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PMC2118063
A control vector (pSR.puro-negative) was constructed using 64-nucleotide sequences (5′-gatccccTGTAGATGGGTACGCGCTCttcaagagaGAGCGCGTACCCATCTACAtttttggaaa-3′ and 5′-agcttttccaaaaaTGTAGATGGGTACGCGCTCtctcttgaaGAGCGCGTACCCATCTACAggg-3′) with no substantial homology to any mammalian gene sequence and thus serves as a nonsilen...
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PMC9429973
Pts with Gr 3–4 ocular symptoms, visual acuity reduced, and keratopathy were 0 (0.0%), 5 (13.9%) and 0 (0.0%), respectively.
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PMC9878562
LECs were purified by staining with APC-conjugated anti-mouse CD31 (Biolegend, clone 390) and positively selected using anti-APC microbeads according to manufacturer’s instructions (Miltenyi Biotec).
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PMC11352666
AKT, a component of the PI3K/AKT pathway activated by MERTK, is known to promote the expression of BCL-2 .
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PMC11760643
Although the mechanism of action of this antibody was not reported, the findings in the current study suggest that the mechanism of action could be due to CDC.
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PMC9784246
Regions of Riyadh, Qassim, Al-Madinah, Al-Hassa, Hail, and Asir recorded the highest prevalence .
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PMC11298021
Accordingly, this concentration was chosen for further investigations.
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PMC6442998
p≤ 0.05.
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PMC11638255
Horizontal line indicates data median.
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PMC11297139
e ChIP assays performed on EWS/FLI1-bound enhancers in ARID1A + WT and ARID1A + ΔDD A673 cell lines using antibodies against IgG, FLI1, H3K27ac, and SMARCC1.
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PMC11459296
We confirmed superior engraftment in all these tissues in NSGS mice (Figure 1J), with a similar representation of the different immune cell subsets across both mouse strains (Figure 1K).
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PMC10840195
In a series of WB analyses, at least three independent experiments were performed with similar results Fig. 7Analysis of the effect of sunitinib on the Wnt/β-catenin pathway and EMT pathway in Twist-overexpressing SR-A498 cells.
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PMC9250505
Organoids were harvested after depolymerization of Matrigel using Cultrex® organoid harvesting solution (R&D systems, US) and organoid pellets were resuspended in RIPA buffer plus protease inhibitors.
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PMC9429973
ECOG performance score was 1 in 75% of our cohort.
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PMC8662250
As expected, in the presence of PPAR‐γ antagonist GW9662 (9 nM), CBD (10 M) incubation did not reach any significant inhibitory effect of SARS‐CoV‐2 SP‐induced proinflammatory cytokine release in the same experimental conditions (Figure 3a–d).
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PMC11754784
Data are represented as mean ± s.d. (
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PMC9429973
Eighteen patients harbored at least one gene mutation detected by Next-generation sequencing (NGS) mutation analysis.
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PMC11463018
m.p.:
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PMC11763126
C Molecular docking predictions of CBDP1 and YTHDF2.
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PMC11750712
Staining was performed on the Leica Bond RX platform with the Bond Polymer refine detection kit (Leica Biosystems).
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PMC11551844
The main differences between the two compounds, as reported by Cayme and Ragasa (2004) are C-NMR signals for C-20, C-22, C-23 and C-24.
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PMC11321678
The CNV profiles showed that immune cells were very conserved among different patients, which suggests that they can serve as a reference to identify CNV events in tumor cells (Figure 2A).
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PMC11286266
Cells within unshadowed rectangles and marked with red delineate those cells expressing moderate/high levels of mTurquoise-tagged plasmid selected for analysis of BiP::sfGFP and XBP1s::mCherry signals distribution.
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PMC11087766
This suggests there could be two major steps in the import process, nuclear targeting and translocation across the nuclear shell, and that the chimera may be a stalled transport intermediate.
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PMC11190538
In addition, total solids supplemented with nanophytosome C-phycocyanin reached a high of 13.98 and 15.13 percent at T3 and T4, respectively.
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PMC10938377
A shift in the P NMR signals was observed from 33.00 ppm for the free complex to 42.31–42.67 ppm for the conjugates, indicating that the environment of the phosphorus is influenced by the introduction of the peptide.
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PMC11534035
Treating CAL39 cells (Figure 2B) with low doses of the GPER1 agonist G1 showed no effect on the gap area.
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PMC10560648
Recent studies have shown that different species of jellyfish can play important roles, including antimicrobial activity, antioxidant effects, and cytotoxicity .
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PMC9780037
First, it is generally inhibited in cancer cells .
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PMC11748335
UTR, untranslated region; TSS, transcription start site; TTS, transcription termination site.
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PMC5810978
then 95°C for 15 min followed by 45 cycles of a 2-step PCR: 95°C for 15 sec, 60°C for 60 sec. Human SaV was quantified with primers SaV124F, 1F, 5F, and 1245R and probes (FAM-) SaV 124TP and SaV 5TP under the following conditions: 50°C for 30 min for reverse transcription, and then 95°C for 15 min followed by 40 cycles...
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PMC11310713
The micro-sized beads can be prepared using the electrostatic extrusion method with isolated GCs and TCs.
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PMC10203589
Its pathogenesis and treatment are complex, and the prognosis becomes worse with increasing age (154, 155).
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PMC9622879
Certain homes within the community only had a PV system as the RES, and a central sharing ESS was integrated into the community to store surplus energy from its members.
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PMC11783017
K7M2 cells were cultured in the upper chamber and DCs were seeded in the lower chamber.
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PMC11323699
CD47 expression was assessed by IHC in paired samples at diagnosis (baseline, green point) and after neoadjuvant chemotherapy (NACT) (orange triangle) (n = 65).
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PMC9429973
The cell dosage of XYF19 was significantly lower than Tecartus and Kymriah, participants were infused with XYF19 CAR-T cells: 3 at low dose (2.0×10/kg), 5 at medium dose (5.0×10/kg), and 3 at high dose (1.0×10/kg).
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PMC9429973
Performance status (PS) at diagnosis was between 0 and 1 in 64%.The functional symptomatology was dominated by abdominal pain; essentially gastric seat (86%) followed by transit disorders (28.5%) and digestive hemorrhage (27%).
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PMC11522251
A range of cytokines and growth factor receptors, such as the epidermal growth factor receptor, activate the transcription factor STAT3 .
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PMC11594588
Epicardial coronary vein thrombosis was demonstrated in 16 of 50 cases.
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PMC11453018
LMNB1+siP15 refers to the condition where LMNB1 is expressed and P15 is knocked down for 48 hours.
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PMC11766309
Our results reveal that YKT6 is a potential prognostic and cancer immunity biomarker.
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PMC11783017
F, G) Representative fluorescent images and quantitative analysis of DCFH-DA staining in 143B cells after treatment for 24 h. (H, I) Live/dead staining of 143B cells after treatment for 24 h using Calcein-AM/PI kit. (
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PMC11243198
BAS 06844821 had more modest effects on the luciferase activity, decreasing the activity by ~40% at the highest dose tested.
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PMC9429973
Patients demographics, AML characteristics, response to treatment and follow up data were collected.
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PMC9429973
The human PK protein in the R-state was used as the starting point of the study (Protein Data Bank entry “2VGB”).
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PMC10936243
Diagram of the explanatory sequential mixed-methods design as adapted for the current experiment (Creswell et al. 2003).
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PMC11746948
Images were captured at a magnification of 20× using the VS200 Research Slide Scanner (Olympus).
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PMC11723947
Statistical significance was calculated using the Pairwise Wilcoxon Rank Sum Test (two-tailed).
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PMC11240571
To confirm non-specific reaction by secondary antibody, Western blotting was performed using a secondary antibody.
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PMC9429973
Summary/Conclusion: This prospective register enrolled patients diagnosed since January 2018 and is of a nationwide scope.
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PMC11569208
VSV expressing shRNA against ACP2 has improved infectivity and oncolysis. (
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PMC9429973
A further decrease in IgM levels was seen after 2 years of maintenance (IgM 3.62 g/dl at baseline; 1.3 g/dl after induction and 0.42 g/dl after end of maintenance, p-value<0.001; Figure 1A), accompanied by a further increase in Hb levels (Hb 10.5 to 14.3 g/dl, p-value<0.001; Figure 1B).
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PMC10203589
The expression level of FGF18 protein in tumor tissues of 12 non-small cell lung cancer (NSCLC) patients was significantly higher than that in adjacent non-tumor tissues, and with the increase of FGF18 expression, the prognosis, tumor differentiation and tumor-lymph node metastasis (TNM) stage of NSCLC patients were al...
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PMC11775197
PPAR plays a noteworthy role in controlling cancer growth .
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PMC6600253
Here, we list only a few examples, which are described below.
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PMC10933092
In summary, the genome-wide integrated analysis of RNA mA methylation and the transcriptome identified mA-regulated mRNAs and lncRNAs and characterized the crosstalk between mRNA and lncRNA mA methylation and expression.
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