OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11576293	See Supplementary Material A1 for more details.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "See", "Supplementary", "Material", "A1", "for", "more", "details", "." ] } ]
PMC11787355	PTPRZ1-derived ligands were found across examined primary glioblastoma cell lines, and PTPRZ1, in particular, was among the overlapping PTPRZ1-derived ligands (Fig. 1h, Supplementary Fig. 1i).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754094	To determine the effect of MMR, we introduced PE3 with pegRNA and an MMR inhibitory factor, hMLH1dn.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "determine", "the", "effect"...
PMC9046263	RNA-in situ hybridization confirms presence of HML-6 provirus RNA in the nucleus (DAPI) and cytoplasm of glioblastoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA-in", "situ", "hybridizat...
PMC11612626	Immunoproteasomes are highly specialized proteasome variants that are expressed at higher levels in antigen-presenting cells and contain replacements of the three constitutive proteasome catalytic subunits to generate peptides with a hydrophobic C-terminus that fit within the groove of MHC class I (MHC-I) molecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10033453	There was also dose-dependent cell death induced by highest concentrations of mIFNβ alone (data not shown).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "also", "dose-dependent", ...
PMC9621239	Representative phylogenetic trees of HBV QS across the X gene from the liver tissue in patients with HCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "phylogenetic", "trees", "o...
PMC9429973	Both ASXL1 MF patients and Asxl1-/-Jak2 mice showed increased monocytes/macrophages in BM (Figure 1C-D), accounting for more severe inflammation in ASXL1 MF patients and mouse models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637276	We previously showed that PAK1 modulates macropinocytosis of Matrigel, collagen I, normal fibroblast- and cancer-associated fibroblast-CDM .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "previously", "showed", "that", "...
PMC6617630	MYC, BCL2, and BCL-6 rearrangements were detected by FISH using break-apart probes carried out in DLBCL cell lines (n = 9) and BL cell line (n = 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594806	Common types of nanoparticles used include liposomes, nanoproducts, inorganic carriers, hydrogels, biomimetic carriers, and cationic polymer nanocarriers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Common", "ty...
PMC11672142	Due to the general low solubility of the compounds in either 1-octanol and water, stock solutions had to first be prepared in dimethyl sulfoxide (DMSO) and then diluted into the two cosolvents to a final 5% DMSO (v/v).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055323	For example, we show that SS18 innate or native condensate could enrich acetyltransferase CBP/p300 while allowing free access of HDAC1/2 (the most abundant HDACs in BJ cells) and corresponding repressor complexes containing HDAC1/2, like SIN3 complex (SIN3A), NuRD complex (RBBP4) and CoREST (RCOR1), into the interior o...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629461	Cells were fixed for DUOX2 (A, B) or DUOXA2 (A′, B′) immunocytochemistry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "fixed", "for", "DUOX2...
PMC11590005	Material and Method: An epidemiological cross-sectional online survey was conducted on 441 Brazilian undergraduate dental students using Google Forms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Material", "and", "Method", ...
PMC10565698	TCF12 expression was lower in cells treated with miR-211-5p mimics than in cells transfected with control miR-NC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TCF12", "expression", "was", "low...
PMC11144382	High retinol (vitamin A1) intake is associated with decreased bone mineral density and increased fracture risk in humans, and high dietary RA in mice has been shown to reduce bone mass by increasing osteoclastogenesis and decreasing osteoblastogenesis, without affecting bone mineralization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: Study ZILO-301 is a Phase 3 randomized, double-blind, placebo-controlled, multicenter study under which pts with R/R MCL will initially receive single agent Ibr (560 mg daily).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720107	In our experiments, the strongest decrease in cell metabolism, as measured by the resazurin reduction test, was observed in BJ and SCC-15 cell lines following treatment with the Ornak and Morado cultivars.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "...
PMC11322866	Anti-p21 (2947T), p-ERK1/2 (9101S), phospho-Rb (Ser780) (9307S), p44/42 MAPK (ERK1/2) (9102S), and EZH2 (5246T) antibodies were purchased from Cell Signaling Technology (Danvers, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11757230	Chronic inflammatory enteropathy (CIE) is a spontaneous gastrointestinal disorder in dogs that resembles inflammatory bowel disease in humans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chronic", "inflammatory", "e...
PMC9429973	Aims: We aimed to further characterize the differentiation and maturation status and in vitro activation capability of T-cells at different stages of CLL (stable and progressive) and to analyze the changes induced on these cells by the BTKi Ibrutinib given as single agent in patients who were in clinical response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	To evaluate the level of cellular association, the cells were seeded one day prior to the experiments into Petri dishes (3.5 cm diameter, nine dishes for each tested cell line) with a density of 7 × 10 cells/dish.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11216402	Briefly, CN variations were identified using CNVkit with default parameters (bcbio-nextgen v0.9.3) (Talevich et al. 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "C...
PMC9429973	Statistical analysis was performed using SPSS program version 20.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", "performed", "using", "SPSS", "program", "version", "20.0", "." ] } ...
PMC11306019	However, combining 1,3,6-triGG and PGG demonstrated synergistic antagonistic effects against BTZ-induced cytotoxicity (Figure 3C; Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "combining", ...
PMC10203589	In qRT-PCR, an evaluation based on FGF18 mRNA levels in 261 invasive breast cancer patients validated the previous prediction (114).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11634027	GAPDH is a control for loading and transfer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GAPDH", "is", "a", "control", "for", "loading", "and", "transfer", "." ] } ]
PMC11607638	Student's t‐test was used for statistical analysis, with a value of p < .05 taken as significant, as indicated by an asterisk (*).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11499381	This difference in minimum size is due to each individual Cos7 cell being larger than an individual HEK293S cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "This", "difference", ...
PMC10940855	We next tested whether Ephb1 expression is also increased in BM ECs in transgenic Vk*MYC mice, which develop indolent myeloma as a consequence of activation-induced deaminase-dependent MYC activation in germinal B cells (42, 43).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10926885	The dynein adaptor protein Lis1 interacts with NDE1, an essential regulator of dynein, to control mitotic events such as spindle aggregation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11271278	SEM: standard error of the mean.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SEM", ":", "standard", "error", "of", "the", "mean", "." ] } ]
PMC11394227	These findings indicate that CHO-PAb-QS cell lines overexpressing survivin exhibit enhanced anti-apoptotic capabilities compared to CHO-PAb cells under the apoptotic induction of puromycin and tunicamycin.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC4395774	The release of Cr in the supernatant was measured with a γ-counter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "release", "of", "Cr", "in", "the", "supernatant", "was", "measured", ...
PMC11279397	This suggested that PEO could be a promising novel anti-IBV drug for inhibiting IBV infection .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggested", "that", "PEO", "could", "be", "a", ...
PMC9844987	ETS factors may therefore play a role in TSS selection in promoters with multi-modal architectures (Lam et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ETS", "facto...
PMC11766174	Here, an automated immunocytochemistry (ICC) assay coupled with computational image analysis to detect and quantify intracellular Gag capsid protein (CA) is described (CA-ICC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11357960	The mRNA expression of SUMO genes (either SUMO1 or SUMO3) plus the only SUMO E2 conjugating enzyme gene (UBE2I) was necessary for SUMOylation, and the abnormal change of their expression had a significant impact on SUMOylation level in PBMC (35).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739504	H&E staining of kidney paraffin sections from 16 weeks Kat2b knockout mice showed glomerular cyst, loosen glomeruli, and dilated tubules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H&E", "stain...
PMC11267830	It attenuates cell proliferation, promotes apoptosis and interferes with cell cycle progression in vitro while facilitating tumor remission in T-ALL in vivo models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10818573	After the reaction temperature was optimized at 39 °C, the reaction time was further adjusted to minimize the experimental time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "the...
PMC7504302	These efforts have identified novel genetic aberrations and confirmed the earlier findings on recurrent alterations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "efforts", "have", "identified", "novel", "genetic", ...
PMC11025866	In tests of infection with other paramyxoviruses, Nipah virus (NiV) and Hendra virus (HeV), CHAC1 expression was not upregulated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC5330095	Antiviral compounds blocking any later step of viral replication such as transcription, translation, pregenome encapsidation, reverse transcription, particle assembly, and release can be identified and characterized using this cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Top DE genes were selected based on P-values <0.05 and log2-fold-change >0.5, comparing MRD+ and MRD6 populations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Top", "DE", "genes", "...
PMC9100622	We show that the mevalonate pathway is essential in Ewing sarcoma and could be a potential new therapeutic target.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "show", "that", "the", ...
PMC11656380	In this study, we developed Tat-Ram13, a 25-mer peptide that fuses the NOTCH1 intracellular domain fragment RAM13 with a cell-penetrating HIV-1 TAT, for the treatment of T-cell acute lymphoblastic leukemia with aberrant NOTCH1 mutation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9927933	DEPTOR knockdown also rescued inactivation of mTORC1/2 by UBE2C knockdown (Figure 6D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DEPTOR", "knockdown", "also", "rescued", "inactivation", "of", "mTORC1...
PMC11772449	H: PFD reduces the number of autophagosomes produced.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", ":", "PFD", "reduces", "the", "number", "of", "autophagosomes", "produced", "." ] } ]
PMC11011837	They could then be used to monitor the tumor, track its severity or progression during treatment, and, within specific biological pathways, could also be used to identify new therapeutic targets, thus allowing the assignment of different therapeutic approaches to patients of the same genetic subgroup, based on this cla...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	F. E. Nicolini, G. Etienne, F. Huguet, M. Gu, C. Bouvier, A. Yocolly, R. Favier, M. Trancart, L. Huynh Centre Leon Berard, Lyon; Institut Bergonié, Bordeaux; Institut Universitaire de Cancérologie de Toulouse, Toulouse, France; Analysis Group, Inc., Boston, MA; Novartis Services, Inc., East Hanover, NJ, United States o...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656657	Importantly, we were also able to prove that CAR.GD2 T-cells were highly effective against primary tumor cells derived from a biopsy of an OS patient (Supplemental Fig. 7), exerting a significant cytotoxicity on tumor cells derived from a lung metastasis of a patient affected by OS (Supplemental Fig. 7A), with the erad...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6163708	HH signaling is a network rather than as a simple linear pathway because of its cooperation with many other cell signaling pathways and its frequent noncanonical activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11300639	Since the sex of the mice had no effect on the results of the study, we chose half the males and half the females for the experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306019	GA is a naturally occurring polyphenol found in a variety of fruits, vegetables, teas, and herbal medicines, commonly present in the foods we consume daily.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Due to the low number of low-risk-patients (n=2) we split the cohort into a “MIPSS70dich” risk group (MIPSS70-low and MIPSS70-intermediate, n=45) and a “MIPSSdich” risk group, comprising the 15 MIPSS70 high-risk patients, for further analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	An allo-HCT was performed in 34 (35%) patients, of whom 19 patients were transplanted in first CR after induction therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11098378	To do this, we chose five effectors: SopB, HopT1-2, HopAM1, Ceg10, and IpaH4 that rescued at least 75% of the arboviruses screened.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8956657	Error bars represent the mean values + /− standard deviation for triplicate experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "represent", "the", "mean", "values", "+", "/−", "sta...
PMC11768927	Shulak et al. demonstrated that treating VSV-resistant PC3 prostate cancer cells with the HDI Vorinostat induced hyperacetylation of the RELA/p65 subunit of NF-κB. This modification enhanced NF-κB activity, leading to suppression of the IFN response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802929	f Bar plots comparing expressed SCTs that captured CD8 T cells (N = 102) vs those that did not (N = 456).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11343332	In six-well plates, 2x105 cells were plated and given a treatment for cancer cells at a concentration of 20 ug/ml for 24 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8701144	The subcellular localization and size of β-catenin degradosomes have been reported to vary between experimental systems and cell lines .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "subcellular", "localization", ...
PMC7039683	This element has peaks of H3K27Ac, IRF6, TP63, and KLF4 ChIP-seq in normal human keratinocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "element", "has", "peaks", "of"...
PMC9429973	GATA1 interactomes in hEBST and HUDEP2 cells highly overlapped and were more similar to GATA1 partners identified in F36P and KMOE, than those of K562 and primary AEL cells.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", ...
PMC11644761	Currently, no definitive therapy exists for age-related neurodegenerative diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", ",", "no", "definitive", "therapy", "exists", "for", "age-related", "neurodegenerative", ...
PMC10317042	CCS cells were seeded at 1 × 10 cells per 6-cm dish and cultured for 24 hours, after which they were treated with 3 μmol/L vorinostat or vehicle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Clinically important SARS-CoV-2 inhibition and protection against severe disease indicated by nAbs ≥50% was detected only in 11/27 patients (40.7%) after the first dose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8711270	Further developments in stable γRV and LV production systems would improve γRV and LV productivities to meet the growing demand of these vectors in clinical gene therapy applications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10079526	I STRING network analysis of enriched SUMOylated proteins upon 20 h of 5-Aza-2’ treatment with Cytoscape software at a confidence score of 0.4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11806613	H Effects of OST-01 on CD44 and CD24 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", "Effects", "of", "OST-01", "on", "CD44", "and", "CD24", "expression", "." ] } ]
PMC11543935	The thermal effect can be monitored with an invasive and non-invasive technique and the first investigations showed reproducible results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "thermal", "effect", "can",...
PMC11792090	PBMCs were obtained from HeYou Biotech and MiaoShun Biotech and activated using anti-CD3/CD28 Dynabeads (Gibco) at a 1:1 bead-to-cell ratio in CTS™ OpTmizer™ T Cell Expansion SFM (Gibco), supplemented with 5% human platelet lysate, 5 ng/mL IL-7, and 10 ng/mL IL-15 (Miltenyi Biotec Technology & Trading Co., Ltd.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	Similar to NG-WSSNMTF, SC-ML cannot achieve convergence on our data-sets and does not produce clusters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "to", "NG-WSSNMTF", ",", "SC-ML", ...
PMC11680982	For HER2-low tumor inhibition rate on day 14: normal saline vs. ET + CDK4/6i, P = 0.0055. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "HER2-low", "tumor", ...
PMC11634794	All cells were incubated at 37°C and 5% CO2 in a humidified incubator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cells", "were", "incubated", "at", "37", ...
PMC9429973	Inhibition of specific EPO signaling showed that Erk1/2 and Stat5 pathways are involved in enhancing Fgf23 and decreasing Galnt3 transcription in EPO-stimulated bone and BM erythroid cells, suggesting a transcriptional regulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748335	A Changes in the enrichment of H3K27me3 long LOCKs in common PMDs or HMDs between normal and tumor cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Changes", "in", "...
PMC11787651	Samples were run by direct injection on a Kinetex XB C18, 100 Å, 2.6 μm, 0.3 × 150 mm column (Phenomenex) at a flow rate of 10 μl/min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Grade ¾ hypocalcemia was noted in 4 of the 24 patients, and one case of osteonecrosis of the jaw (ONJ) requiring definitive discontinuation of Denosumab.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540692	The combination treatment consisted of 1 µM CCM and 5 mM NaBu, irrespective of the cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "treatment", "consisted...
PMC11672602	The original article has been updated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "original", "article", "has", "been", "updated", "." ] } ]
PMC9429973	In 12 patients, hemolytic spherocytic anemia was confirmed by blood smear, complete blood count, haptoglobin, bilirubin, osmotic resistance test, and flow cytometric eosin-5-maleimide binding test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7553912	OSM may promote the formation of renal crystal deposits by directly acting on RTECs and renal fibroblasts to produce crystal-binding molecules and inflammatory cytokines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9027909	No human or animal tissues were analyzed in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "human", "or", "animal", "tissues", "were", "analyzed", "in", "this", "study", "." ...
PMC9429973	These patients fail to produce functional β-globin, resulting in severe anemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "patients", "fail", "to", "produce", "functional", "β-globin", ",", "res...
PMC11087766	Phage stocks of PhiKZ and PhiPA3 were collected from plate lysates using phage buffer [10 mM Tris (pH 7.5), 10 mM MgSO4, 68 mM NaCl, and 1 mM CaCl2] and stored at 4 °C with titers of ~10 PFU/mL. E. coli MC1000 was used as the host for Goslar.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patient 1 had been diagnosed with Hodgkin’s lymphoma 2 years earlier, previous treatment included zolendronic acid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patient", "1", "had", "been", "diagnos...
PMC9436459	All six type D-I MDAAs with the diene moiety at C-8 of A ring, namely kuwanon G (92), kuwanon H (93), mongolicin D (94), moracenin D (95), moracenin E (96), kuwanon W (97), are provided with trans–trans configuration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055510	The results of EdU showed that the EdU incorperation in the si-IL1RAP group was significantly lower than that in the si-nc group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resul...
PMC8270637	Moreover, the overexpression of TGF-β1 correlated with the progression and prognosis of HCC (4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "overexpression", "of", ...
PMC11604830	After the acquisition of scout images, and the performance of proper shimming protocol (see Data S1) an anatomical image of the tumor was acquired (RARE, Matrix = 128 x 128 pixels, FOV = 30 x 30 mm, spatial resolution = 0.234 x 0.234 mm/pixel, TR = 5 s, TE = 21.6 ms, RF = 8, slice thickness = 1 mm, NA = 2, acq.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11789597	151 genes and 102 genes were up‐regulated and down‐regulated, respectively, by CAV1 knockdown (Figure S5A, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "151", "genes...
PMC10547921	Most of the second-generation ADCs used significantly more potent tubulin inhibitors as payloads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "of", "the", "second-generation", "ADCs", "used", "significantly", "...
PMC9964635	Each ligand’s hydrophobic contacts and hydrogen bonding interactions were evaluated within the receptor protein’s binding pocket.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "ligand", "’s", "hydrophobic", ...
PMC8584666	GPI-80, identified in human neutrophils , has been reported to regulate neutrophil adhesion and migration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GPI-80", ",", "identified", "in", "human", "neutrophil...
PMC10154097	circSOX4 was confirmed to target miR-218-5p, and the effect of circSOX4 downregulation on inhibiting tumor growth was diminished after miR-218-5p inhibition or YY1 overexpression in HCC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	Multiple myeloma cells were seeded on matrigel, spheroids allowed to form and the spheroids were then treated with either tubastatin-A, ACY-1215, or ACY738.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10040136	Correlation analysis showed that MSC proportion in these samples was negatively correlated with the progression-free survival of the patients (Fig. 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Correla...

PMC11576293

See Supplementary Material A1 for more details.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "See", "Supplementary", "Material", "A1", "for", "more", "details", "." ] } ]

PMC11787355

PTPRZ1-derived ligands were found across examined primary glioblastoma cell lines, and PTPRZ1, in particular, was among the overlapping PTPRZ1-derived ligands (Fig. 1h, Supplementary Fig. 1i).Fig.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11754094

To determine the effect of MMR, we introduced PE3 with pegRNA and an MMR inhibitory factor, hMLH1dn.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "determine", "the", "effect"...

PMC9046263

RNA-in situ hybridization confirms presence of HML-6 provirus RNA in the nucleus (DAPI) and cytoplasm of glioblastoma cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA-in", "situ", "hybridizat...

PMC11612626

Immunoproteasomes are highly specialized proteasome variants that are expressed at higher levels in antigen-presenting cells and contain replacements of the three constitutive proteasome catalytic subunits to generate peptides with a hydrophobic C-terminus that fit within the groove of MHC class I (MHC-I) molecules.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10033453

There was also dose-dependent cell death induced by highest concentrations of mIFNβ alone (data not shown).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "also", "dose-dependent", ...

PMC9621239

Representative phylogenetic trees of HBV QS across the X gene from the liver tissue in patients with HCC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "phylogenetic", "trees", "o...

PMC9429973

Both ASXL1 MF patients and Asxl1-/-Jak2 mice showed increased monocytes/macrophages in BM (Figure 1C-D), accounting for more severe inflammation in ASXL1 MF patients and mouse models.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11637276

We previously showed that PAK1 modulates macropinocytosis of Matrigel, collagen I, normal fibroblast- and cancer-associated fibroblast-CDM .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "previously", "showed", "that", "...

PMC6617630

MYC, BCL2, and BCL-6 rearrangements were detected by FISH using break-apart probes carried out in DLBCL cell lines (n = 9) and BL cell line (n = 2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11594806

Common types of nanoparticles used include liposomes, nanoproducts, inorganic carriers, hydrogels, biomimetic carriers, and cationic polymer nanocarriers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Common", "ty...

PMC11672142

Due to the general low solubility of the compounds in either 1-octanol and water, stock solutions had to first be prepared in dimethyl sulfoxide (DMSO) and then diluted into the two cosolvents to a final 5% DMSO (v/v).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11055323

For example, we show that SS18 innate or native condensate could enrich acetyltransferase CBP/p300 while allowing free access of HDAC1/2 (the most abundant HDACs in BJ cells) and corresponding repressor complexes containing HDAC1/2, like SIN3 complex (SIN3A), NuRD complex (RBBP4) and CoREST (RCOR1), into the interior o...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11629461

Cells were fixed for DUOX2 (A, B) or DUOXA2 (A′, B′) immunocytochemistry.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "fixed", "for", "DUOX2...

PMC11590005

Material and Method: An epidemiological cross-sectional online survey was conducted on 441 Brazilian undergraduate dental students using Google Forms.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Material", "and", "Method", ...

PMC10565698

TCF12 expression was lower in cells treated with miR-211-5p mimics than in cells transfected with control miR-NC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TCF12", "expression", "was", "low...

PMC11144382

High retinol (vitamin A1) intake is associated with decreased bone mineral density and increased fracture risk in humans, and high dietary RA in mice has been shown to reduce bone mass by increasing osteoclastogenesis and decreasing osteoblastogenesis, without affecting bone mineralization.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Methods: Study ZILO-301 is a Phase 3 randomized, double-blind, placebo-controlled, multicenter study under which pts with R/R MCL will initially receive single agent Ibr (560 mg daily).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11720107

In our experiments, the strongest decrease in cell metabolism, as measured by the resazurin reduction test, was observed in BJ and SCC-15 cell lines following treatment with the Ornak and Morado cultivars.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "...

PMC11322866

Anti-p21 (2947T), p-ERK1/2 (9101S), phospho-Rb (Ser780) (9307S), p44/42 MAPK (ERK1/2) (9102S), and EZH2 (5246T) antibodies were purchased from Cell Signaling Technology (Danvers, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11757230

Chronic inflammatory enteropathy (CIE) is a spontaneous gastrointestinal disorder in dogs that resembles inflammatory bowel disease in humans.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chronic", "inflammatory", "e...

PMC9429973

Aims: We aimed to further characterize the differentiation and maturation status and in vitro activation capability of T-cells at different stages of CLL (stable and progressive) and to analyze the changes induced on these cells by the BTKi Ibrutinib given as single agent in patients who were in clinical response.

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PMC11721277

To evaluate the level of cellular association, the cells were seeded one day prior to the experiments into Petri dishes (3.5 cm diameter, nine dishes for each tested cell line) with a density of 7 × 10 cells/dish.

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PMC11216402

Briefly, CN variations were identified using CNVkit with default parameters (bcbio-nextgen v0.9.3) (Talevich et al. 2016).

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PMC9429973

Statistical analysis was performed using SPSS program version 20.0.

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PMC11306019

However, combining 1,3,6-triGG and PGG demonstrated synergistic antagonistic effects against BTZ-induced cytotoxicity (Figure 3C; Table 2).

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PMC10203589

In qRT-PCR, an evaluation based on FGF18 mRNA levels in 261 invasive breast cancer patients validated the previous prediction (114).

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PMC11634027

GAPDH is a control for loading and transfer.

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PMC11607638

Student's t‐test was used for statistical analysis, with a value of p < .05 taken as significant, as indicated by an asterisk (*).

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PMC11499381

This difference in minimum size is due to each individual Cos7 cell being larger than an individual HEK293S cell.

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PMC10940855

We next tested whether Ephb1 expression is also increased in BM ECs in transgenic Vk*MYC mice, which develop indolent myeloma as a consequence of activation-induced deaminase-dependent MYC activation in germinal B cells (42, 43).

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PMC10926885

The dynein adaptor protein Lis1 interacts with NDE1, an essential regulator of dynein, to control mitotic events such as spindle aggregation.

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PMC11271278

SEM: standard error of the mean.

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PMC11394227

These findings indicate that CHO-PAb-QS cell lines overexpressing survivin exhibit enhanced anti-apoptotic capabilities compared to CHO-PAb cells under the apoptotic induction of puromycin and tunicamycin.

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PMC4395774

The release of Cr in the supernatant was measured with a γ-counter.

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PMC11279397

This suggested that PEO could be a promising novel anti-IBV drug for inhibiting IBV infection .

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PMC9844987

ETS factors may therefore play a role in TSS selection in promoters with multi-modal architectures (Lam et al., 2019).

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PMC11766174

Here, an automated immunocytochemistry (ICC) assay coupled with computational image analysis to detect and quantify intracellular Gag capsid protein (CA) is described (CA-ICC).

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PMC11357960

The mRNA expression of SUMO genes (either SUMO1 or SUMO3) plus the only SUMO E2 conjugating enzyme gene (UBE2I) was necessary for SUMOylation, and the abnormal change of their expression had a significant impact on SUMOylation level in PBMC (35).

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PMC11739504

H&E staining of kidney paraffin sections from 16 weeks Kat2b knockout mice showed glomerular cyst, loosen glomeruli, and dilated tubules.

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PMC11267830

It attenuates cell proliferation, promotes apoptosis and interferes with cell cycle progression in vitro while facilitating tumor remission in T-ALL in vivo models.

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PMC10818573

After the reaction temperature was optimized at 39 °C, the reaction time was further adjusted to minimize the experimental time.

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PMC7504302

These efforts have identified novel genetic aberrations and confirmed the earlier findings on recurrent alterations .

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PMC11025866

In tests of infection with other paramyxoviruses, Nipah virus (NiV) and Hendra virus (HeV), CHAC1 expression was not upregulated.

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PMC5330095

Antiviral compounds blocking any later step of viral replication such as transcription, translation, pregenome encapsidation, reverse transcription, particle assembly, and release can be identified and characterized using this cell line.

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PMC9429973

Top DE genes were selected based on P-values <0.05 and log2-fold-change >0.5, comparing MRD+ and MRD6 populations.

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PMC9100622

We show that the mevalonate pathway is essential in Ewing sarcoma and could be a potential new therapeutic target.

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PMC11656380

In this study, we developed Tat-Ram13, a 25-mer peptide that fuses the NOTCH1 intracellular domain fragment RAM13 with a cell-penetrating HIV-1 TAT, for the treatment of T-cell acute lymphoblastic leukemia with aberrant NOTCH1 mutation.

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PMC9927933

DEPTOR knockdown also rescued inactivation of mTORC1/2 by UBE2C knockdown (Figure 6D).

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PMC11772449

H: PFD reduces the number of autophagosomes produced.

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PMC11011837

They could then be used to monitor the tumor, track its severity or progression during treatment, and, within specific biological pathways, could also be used to identify new therapeutic targets, thus allowing the assignment of different therapeutic approaches to patients of the same genetic subgroup, based on this cla...

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PMC9429973

F. E. Nicolini, G. Etienne, F. Huguet, M. Gu, C. Bouvier, A. Yocolly, R. Favier, M. Trancart, L. Huynh Centre Leon Berard, Lyon; Institut Bergonié, Bordeaux; Institut Universitaire de Cancérologie de Toulouse, Toulouse, France; Analysis Group, Inc., Boston, MA; Novartis Services, Inc., East Hanover, NJ, United States o...

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PMC11656657

Importantly, we were also able to prove that CAR.GD2 T-cells were highly effective against primary tumor cells derived from a biopsy of an OS patient (Supplemental Fig. 7), exerting a significant cytotoxicity on tumor cells derived from a lung metastasis of a patient affected by OS (Supplemental Fig. 7A), with the erad...

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PMC6163708

HH signaling is a network rather than as a simple linear pathway because of its cooperation with many other cell signaling pathways and its frequent noncanonical activation.

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PMC11300639

Since the sex of the mice had no effect on the results of the study, we chose half the males and half the females for the experiment.

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PMC11306019

GA is a naturally occurring polyphenol found in a variety of fruits, vegetables, teas, and herbal medicines, commonly present in the foods we consume daily.

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PMC9429973

Due to the low number of low-risk-patients (n=2) we split the cohort into a “MIPSS70dich” risk group (MIPSS70-low and MIPSS70-intermediate, n=45) and a “MIPSSdich” risk group, comprising the 15 MIPSS70 high-risk patients, for further analyses.

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PMC9429973

An allo-HCT was performed in 34 (35%) patients, of whom 19 patients were transplanted in first CR after induction therapy.

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PMC11098378

To do this, we chose five effectors: SopB, HopT1-2, HopAM1, Ceg10, and IpaH4 that rescued at least 75% of the arboviruses screened.

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PMC8956657

Error bars represent the mean values + /− standard deviation for triplicate experiments.

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PMC11768927

Shulak et al. demonstrated that treating VSV-resistant PC3 prostate cancer cells with the HDI Vorinostat induced hyperacetylation of the RELA/p65 subunit of NF-κB. This modification enhanced NF-κB activity, leading to suppression of the IFN response.

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PMC11802929

f Bar plots comparing expressed SCTs that captured CD8 T cells (N = 102) vs those that did not (N = 456).

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PMC11343332

In six-well plates, 2x105 cells were plated and given a treatment for cancer cells at a concentration of 20 ug/ml for 24 hours.

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PMC8701144

The subcellular localization and size of β-catenin degradosomes have been reported to vary between experimental systems and cell lines .

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PMC7039683

This element has peaks of H3K27Ac, IRF6, TP63, and KLF4 ChIP-seq in normal human keratinocytes.

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PMC9429973

GATA1 interactomes in hEBST and HUDEP2 cells highly overlapped and were more similar to GATA1 partners identified in F36P and KMOE, than those of K562 and primary AEL cells.

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PMC11644761

Currently, no definitive therapy exists for age-related neurodegenerative diseases.

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PMC10317042

CCS cells were seeded at 1 × 10 cells per 6-cm dish and cultured for 24 hours, after which they were treated with 3 μmol/L vorinostat or vehicle.

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PMC9429973

Clinically important SARS-CoV-2 inhibition and protection against severe disease indicated by nAbs ≥50% was detected only in 11/27 patients (40.7%) after the first dose.

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PMC8711270

Further developments in stable γRV and LV production systems would improve γRV and LV productivities to meet the growing demand of these vectors in clinical gene therapy applications.

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PMC10079526

I STRING network analysis of enriched SUMOylated proteins upon 20 h of 5-Aza-2’ treatment with Cytoscape software at a confidence score of 0.4.

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PMC11806613

H Effects of OST-01 on CD44 and CD24 expression.

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PMC11543935

The thermal effect can be monitored with an invasive and non-invasive technique and the first investigations showed reproducible results.

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PMC11792090

PBMCs were obtained from HeYou Biotech and MiaoShun Biotech and activated using anti-CD3/CD28 Dynabeads (Gibco) at a 1:1 bead-to-cell ratio in CTS™ OpTmizer™ T Cell Expansion SFM (Gibco), supplemented with 5% human platelet lysate, 5 ng/mL IL-7, and 10 ng/mL IL-15 (Miltenyi Biotec Technology & Trading Co., Ltd.).

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PMC6379402

Similar to NG-WSSNMTF, SC-ML cannot achieve convergence on our data-sets and does not produce clusters.

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PMC11680982

For HER2-low tumor inhibition rate on day 14: normal saline vs. ET + CDK4/6i, P = 0.0055. (

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PMC11634794

All cells were incubated at 37°C and 5% CO2 in a humidified incubator.

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PMC9429973

Inhibition of specific EPO signaling showed that Erk1/2 and Stat5 pathways are involved in enhancing Fgf23 and decreasing Galnt3 transcription in EPO-stimulated bone and BM erythroid cells, suggesting a transcriptional regulation.

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PMC11748335

A Changes in the enrichment of H3K27me3 long LOCKs in common PMDs or HMDs between normal and tumor cell lines.

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PMC11787651

Samples were run by direct injection on a Kinetex XB C18, 100 Å, 2.6 μm, 0.3 × 150 mm column (Phenomenex) at a flow rate of 10 μl/min.

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PMC9429973

Grade ¾ hypocalcemia was noted in 4 of the 24 patients, and one case of osteonecrosis of the jaw (ONJ) requiring definitive discontinuation of Denosumab.

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PMC8540692

The combination treatment consisted of 1 µM CCM and 5 mM NaBu, irrespective of the cell line.

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PMC11672602

The original article has been updated.

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PMC9429973

In 12 patients, hemolytic spherocytic anemia was confirmed by blood smear, complete blood count, haptoglobin, bilirubin, osmotic resistance test, and flow cytometric eosin-5-maleimide binding test.

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PMC7553912

OSM may promote the formation of renal crystal deposits by directly acting on RTECs and renal fibroblasts to produce crystal-binding molecules and inflammatory cytokines.

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PMC9027909

No human or animal tissues were analyzed in this study.

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PMC9429973

These patients fail to produce functional β-globin, resulting in severe anemia.

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PMC11087766

Phage stocks of PhiKZ and PhiPA3 were collected from plate lysates using phage buffer [10 mM Tris (pH 7.5), 10 mM MgSO4, 68 mM NaCl, and 1 mM CaCl2] and stored at 4 °C with titers of ~10 PFU/mL. E. coli MC1000 was used as the host for Goslar.

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PMC9429973

Patient 1 had been diagnosed with Hodgkin’s lymphoma 2 years earlier, previous treatment included zolendronic acid.

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PMC9436459

All six type D-I MDAAs with the diene moiety at C-8 of A ring, namely kuwanon G (92), kuwanon H (93), mongolicin D (94), moracenin D (95), moracenin E (96), kuwanon W (97), are provided with trans–trans configuration.

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PMC11055510

The results of EdU showed that the EdU incorperation in the si-IL1RAP group was significantly lower than that in the si-nc group.

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PMC8270637

Moreover, the overexpression of TGF-β1 correlated with the progression and prognosis of HCC (4).

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PMC11604830

After the acquisition of scout images, and the performance of proper shimming protocol (see Data S1) an anatomical image of the tumor was acquired (RARE, Matrix = 128 x 128 pixels, FOV = 30 x 30 mm, spatial resolution = 0.234 x 0.234 mm/pixel, TR = 5 s, TE = 21.6 ms, RF = 8, slice thickness = 1 mm, NA = 2, acq.

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PMC11789597

151 genes and 102 genes were up‐regulated and down‐regulated, respectively, by CAV1 knockdown (Figure S5A, Supporting Information).

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PMC10547921

Most of the second-generation ADCs used significantly more potent tubulin inhibitors as payloads.

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PMC9964635

Each ligand’s hydrophobic contacts and hydrogen bonding interactions were evaluated within the receptor protein’s binding pocket.

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PMC8584666

GPI-80, identified in human neutrophils , has been reported to regulate neutrophil adhesion and migration .

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PMC10154097

circSOX4 was confirmed to target miR-218-5p, and the effect of circSOX4 downregulation on inhibiting tumor growth was diminished after miR-218-5p inhibition or YY1 overexpression in HCC cells.

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PMC11188874

Multiple myeloma cells were seeded on matrigel, spheroids allowed to form and the spheroids were then treated with either tubastatin-A, ACY-1215, or ACY738.

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PMC10040136

Correlation analysis showed that MSC proportion in these samples was negatively correlated with the progression-free survival of the patients (Fig. 1C).

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