OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	Aims: Comparison of the process of maintenance therapy, efficacy, and prognosis between RAD induction and PAD induction in patients in previous clinical studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11730311	Peptides were quantified based on the extracted ion chromatogram (EIC) of their highest isotopic peak.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Peptides", "were", "quantified", "based", "on", ...
PMC9429973	IV glofitamab was then given as step-up doses on Day (D) 1 (2.5mg) and D8 (10mg) of C1 and at the target dose (30mg) on D1 of C2–12 (21-day cycles).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655498	The emergence of numerous innovative technologies and methodologies enables a deeper understanding of the mechanisms underlying EBV latency and reactivation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "emergence", "of", ...
PMC11401358	Flow cytometry detection of ROS levels in untreated and (GAGSGA)2-treated NIH 3T3 cells incubated with H2O2. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "detection", "of"...
PMC10123657	After 24 h of co-culture, 1513 and 67 proteins from human and mouse origin, respectively, were identified in CCRF-CEM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ ...
PMC11711063	ZG16B and Bex + Carv antagonize in defining cell identity, and suppressing or inducing basal characteristics, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ZG16B", "and", "Bex", "+", ...
PMC11597291	The nCGO-PEG(10 kDa) particles were labeled with FITC, which was conjugated through EDC chemistry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "nCGO-PEG(10", "kDa", ")", "particles", "were", ...
PMC11718809	The GC content ranged from 50.51% to 53.23%, and the Q30 content from 96.35% to 96.53% (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11502066	The data presented in this review article clearly show that flavonoids can exert important anticancer effects through acting on different types of GPCRs, highlighting these natural polyphenols as potential drug candidates for the treatment of human malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3681794	Drug response was assessed using the sulphorhodamine-B (SRB) assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Drug", "response", "was", "assessed", "using", "the", "sulphorhodamine-B", "(", "SRB", ...
PMC11718809	These DECs were derived from four host genes: retinoblastoma binding protein 8 (RBBP8), tetratricopeptide repeat, ankyrin repeat, and coiled-coil containing 1 (TANC1), sorting nexin-29 (SNX29) and tousled-like kinase 2 (TLK2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	Taken together, our data suggests that our cobalt complexes can interact with DNA possibly by a groove binding mechanism (Figure S18) but particularly, can induce DNA damage (cleavage) (Figures S12–S16).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10994876	Despite advancements, most techniques focus on specific genes to address individual cellular challenges.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "advancements", ",", "most", "techniques", "focus", "on", ...
PMC7504302	Specifically, triple knockout animals developed highly invasive and proliferative tumors, predominantly with sarcomatoid histologic subtype, recapitulating the human MPMs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specifically", ...
PMC11806818	Key targets in liquid biopsy include circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), extracellular vesicles (EVs), and circulating tumor RNA (ctRNA) [2–5].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10878518	The GFP gene expression cassette under the control of cytomegalovirus promoter was inserted into the E3 region of OBP-301 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "GFP", "gene", "expression"...
PMC8584666	In the future, sGPI-80 released into the blood may be a useful index for examining chronic inflammation and immunosuppression in cancer patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC8345486	Among them, compound 23 showed the highest accumulation, and compound 14 showed the lowest accumulation, which corresponded to their toxicity potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11539788	Novel insights into the driver genes of BCa aggressiveness could provide better therapeutic modalities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Novel", "insights", "into", "the", "driver", "genes", "of", "BCa...
PMC10743717	The Human Genome Organization (HUGO) announced in 2007 that HSD17B10 serves as the official symbol of this gene and thus the terminology of the gene product is type 10 17β-hydroxysteroid dehydrogenase .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792090	The CAR-T cells were then rechallenged with 786-0-luc cells for a total of four rounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CAR-T", "cells", "were", "then", "re...
PMC9429973	Applying breakpoint-spanning PCR, validated aberrations were used as markers for assessment of minimal residual disease (MRD) in selected cases during AML treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11537649	Lnc NEAT1 was knocked down in A375 cells with miR-152-3p inhibitor or CDK6 overexpressing. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lnc", "NEAT1", "was", "knocked", "down",...
PMC9960565	In the ¹H-NMR experiments, the signal of deuterated water (D2O) was used as an internal reference, while potassium tetrachloroplatinate (II) was used as the external reference in the ¹⁹⁵Pt-NMR experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306019	Correlation between number of VDMs in 11 polyphenols and their AI values.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Correlation", "between", "number", "of", "VDMs", "in", "11", "polyphenols", "and...
PMC9429973	It is well known that ABO antigens are expressed on respiratory epithelial cells, however these antigens called type-1 antigens which differ from type-2 antigens expressed on red blood cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5308810	This can be a useful approach to study the functional roles and targeting benefits of a particular or multiple CSC populations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "can", "be...
PMC10218459	The treatment was performed similarly to the TUNEL assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "treatment", "was", "performed", "similarly", "to", "the", "TUNEL", "assay", "." ] } ]
PMC11342785	Human FUS (residues 1–214) was amplified by PCR using pHR-FUSN-mCh-Cry2WT (Addgene #101223).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "FUS", "(", "residues", "1–214", ")...
PMC9429973	11-colour flow cytometry was performed after cells were activated with H2O2 for 15 minutes, due to its activity as a potent phosphatase inhibitor and cells were analysed for phosphorylation of ZAP70 as a surrogate of TCR signalling and STAT5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11681005	These results suggest that DNA hypermethylation might not necessarily be transcriptionally suppressive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "that", "DNA", "hypermethylation", "might", "not", ...
PMC11684297	The zeta potential was − 12 mV, which shows that the synthesized ZnO-NFs were relatively stable (Fig. 1c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "zeta", "po...
PMC11697065	1Generation and Characterisation of Stable CHO Cell Pools Expressing Different Antibody Format Biotherapeutics.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1Generation", "and", "Characterisation", "of", "Stable", "CHO", "Cell", ...
PMC9429973	Image: Summary/Conclusion: Parsaclisib was generally well tolerated and resulted in Hgb improvements as early as Wk 2 that increased over 12 wk of treatment and were sustained through the extension period.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	Degradation rate of hydrogels at different H2O2 concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Degradation", "rate", "of", "hydrogels", "at", "different", "H2O2", "concentrations", "." ] } ]
PMC11310713	After 4 to 5 weeks, when serum sex hormone levels reached a stable baseline, the OVX rats had a GTB injection (n = 9) or 4 types of pharmaceutical hormone delivery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707577	The Hydra Elongation factor 1‐alpha (Ef‐1α) was used as reference gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Hydra", "Elongation", "factor", "1‐alpha", "(", "Ef‐1α", ")", ...
PMC11599565	At least 20 “twin” cells and a proportional amount of surrounding normal cells were collected for single-cell RNA isolation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "least", "20...
PMC9429973	These results do not support different treatment strategies for EN disease; however, due to limited sample size the role of RT and the prognostic impact of specific locations cannot be fully ascertained.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Glucarpidase, approved for use in pts with delayed MTX clearance, is a zinc-dependent enzyme, which rapidly cleaves MTX into non-toxic metabolites and offers an alternative route of MTX elimination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422497	Primary antibodies were then applied to the membranes and allowed to incubate overnight at 4 °C, facilitating specific binding to target proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8973085	To illustrate the potential binding mode of pyridine derivatives into the active sites of the three types of tumor cells we investigated (HCT-116, HepG-2 and MCF-7), a docking study of the most active derivatives against each cell type using MOE (2014.0901) (Molecular Operating Environment software).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLin...
PMC11609529	This dependency suggests that ES-2 cells are susceptible to inhibitors targeting the YAP1/TEAD transcriptional program.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "dependency", "suggests", "that", "ES-2", "cells"...
PMC11665555	Among other genes significantly altered by the OXCT1 KO, a member of the epidermal growth factor receptor (EGFR) family, ERBB2, was downregulated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Most patients presented ITD FLT3 (80%), 56% were refractory and 44% were relapsed (CR1 duration ≥6 months in 60%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11468365	Fig. 8The of sensitivity score over the 7 tissue types of the cancer cell line The of sensitivity score over the 7 tissue types of the cancer cell line The top ten MultiComb predicted sensitivity scores are compared with actual sensitivity scores in Fig. 9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11519583	The stained cells were rinsed with 60% (v/v) isopropanol and then incubated in 100% isopropanol for 20 min to extract the Oil Red O incorporated into adipocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10253553	Pathways induced by VEGF include mTOR .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pathways", "induced", "by", "VEGF", "include", "mTOR", "." ] } ]
PMC11618052	C NMR (100 MHz, δ ppm DMSO-d6): 160.86, 156.49, 147.32, 143.95, 135.77, 135.37, 135.05, 133.03, 130.06, 129.92, 129.61, 129.51, 126.64, 126.30, 126.18, 122.29, 121.83, 119.71, 26.66.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11568601	was used to enhance the staining intensity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "was", "used", "to", "enhance", "the", "staining", "intensity", "." ] } ]
PMC11597291	The only exception was the nCGO-PEG(2 kDa) particles, which showed an increase in size after a week’s time storage, assuming a value around 300 nm, which, however, remained essentially constant for the remaining storage time (Figure 2A,B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11532793	With bootstrap sampling, kallisto was approximately 45% faster than Salmon, taking between 5 and 12 min to quantify libraries with 25 and 100 million reads pairs, respectively (Supplementary Table S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Only one subject in the 55 mg group experienced DLT (Grade 3 QT prolongation), and MTD had not been reached.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", ...
PMC11754784	b The logic flowchart and truth table of DNP1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "The", "logic", "flowchart", "and", "truth", "table", "of", "DNP1", "." ] } ]
PMC9429973	17 patients developed CMV-DNAemia in haplo-cord transplant and 9 in haplo patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "17", "patients", "developed", "CMV-DNAemia", "in", "haplo-cord", "transplant", "and", ...
PMC11301242	Conversely, none of the normal blood samples exhibited valid amplification (Fig. 1B; Supplementary Fig. 1C; Supplementary Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Convers...
PMC11721096	The obtained A. sparsifolia and C. arabica extract was prepared as a 1 mg/mL solution designated as S0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "obtained", "A.", "sparsifolia", ...
PMC7504302	The siRNA library used in this work consisted of nine sub-libraries, namely, ion binding, ion channel, kinase, membrane transporter, nucleic acid binding, phosphatase, receptor, transcription factor, and transporter, culminating to 8589 siRNAs in total.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11271800	It exerts anti-tumor activity by directly killing GIST tumor cells and indirectly affecting immune cells, especially in patients with large, difficult-to-resect tumors, locally advanced tumors, and post-operative adjuvant therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11541241	In contrast, the FATC domain was not identified in the FoTOR2 (Figure S1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "the", "FATC", "domain", "...
PMC11036064	Consistent with this, we have shown that the combination therapy of temozolomide with ectopic expression of 10 pmol hsa-miR-34a-5p is superior to monotherapy with temozolomide and mono-therapy with 10 pmol hsa-miR-34a-5p ectopic expression in terms of inducing cytotoxicity (both P-values <0.0001) (Figure 7E(Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11285179	Western blot experiments revealed that the expression of CCR3 was significantly higher than that of CCR10 in pericytes, suggesting that CCR3 likely plays a predominant role in mediating CCL28 signal transduction within pericytes (Fig. 2F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240	Here, only two residues showed interactions with more than 50% of the evaluated time LYS310 and ASN314, and these were through weak forces (van der Waals, hydrophobic).Figure 11Energy decomposition of the interaction per residue in the last 10 ns of simulations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11678130	Apoptosis is usually characterized by a series of rearrangements within the intracellular compartment that affect the nuclei and the cytoskeleton: nuclear chromatin becomes condensed and is fragmented into apoptotic bodies, whereas tubulin and F-actin constrict and form thick bundles .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11555465	Zhou et al (33) report that T. gondii rhoptry protein 18 reduces human glioma cell apoptosis via a mitochondrial route, targeting host cell P2X1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670407	f Representative images of immunofluorescence staining for the colocalization of GPX4 and OTULIN in U2OS cells (scale bar: 20 μm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11515150	The humanized VHH fragments were subcloned into E. coli TG1 strains, and tagged with 6xHis tag for purification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "humanized", "VHH", "fragme...
PMC8759873	Lalif successfully cloned the VHL gene in 1993 and confirmed that the root cause of VHL disease is VHL gene inactivation, and VHL exists in more than 98% of VHL diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	Bars represent the mean ± SD from five independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bars", "represent", "the", "mean", "±", "SD", "from", "five", "independent", "experiments", ...
PMC11657695	The whiskers indicate the fifth and the ninety-fifth percentiles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "whiskers", "indicate", "the", "fifth", "and", "the", "ninety-fifth", "percentiles", "." ] } ]
PMC10604092	Moreover, we measured the mRNA levels of muscle-specific degradation factors associated with muscle atrophy in cancer cachexia .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "we", "measured", "the...
PMC8389560	It is known that in astrocytes, which, much like glioblastoma, are also electrically excitable cells, an increase in [Ca]i causes the release of glutamate and other transmitters, primarily ATP .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786600	However, when the PF-127 content of PED3 reached 20%, the contact angle of PED3 slowly decreased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "when", "the", ...
PMC11462929	We then tried to verify whether BENC‐CNA is associated with higher MYC expression in BCP‐ALL cell lines using NALM6 as a control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC9429973	There was no difference in the proportion of cell subtypes and expression of exhausted biomarkers between CD7- and CD7+ T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was...
PMC10887351	However, recent studies reported that β3-AR-KO increased the high fat diet, inducing more severe obesity, with WAT hypertrophy and inflammation, compared to wild-type mice .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10978090	2 3 Another strategy is to combine intraoperative unfractionated heparin (UFH) with a potent parenteral antiplatelet agent that prevents HIT-mediated platelet aggregation during cardiopulmonary bypass (CBP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	Divide a volume of cell suspension expected to yield 10–12 mg protein over 50‐ml tubes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Divide", "a", "volume", "of", "cell", "suspension", "expect...
PMC11138140	While we attempted to start our digital holographic imaging time-course experiments soon after norepinephrine treatment, the time it took to initiate our time-lapse movies after treatment ranged from 1 to 2 h due to technical obstacles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721295	Samples were processed simultaneously to avoid batch effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Samples", "were", "processed", "simultaneously", "to", "avoid", "batch", "effects", "." ] } ]
PMC11335267	Briefly, serial consecutive images of an axial slice containing the hypothalamus were obtained using nine “high b” (300 < b < 2000 s/µm) values in three orthogonal directions: Head-Foot (H-F), Left-Right (L-R) and Antero-Posterior (A-P).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782780	Western blot analysis was employed to assess the expression of stem cell-related markers and proteins associated with the glycolysis metabolic pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", ...
PMC11679326	Further studies of AVL lectin revealed that as part of an oncolytic virus, it induces metabolic reprogramming in hepatocellular carcinoma cells by stimulating the production of reactive oxygen species (ROS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742290	LGR5 has been linked to angiogenesis through its role in promoting CSC, secreting angiogenic factors like VEGF, and interacting with the TME, all of which contribute to tumor vascularization and progression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637276	The survival analysis was performed using Kaplan–Meier plotter (https://kmplot.com/analysis/), which can assess the effect of genes of interest on survival in 21 cancer types, including pancreatic cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731614	N = 3 biological replicates of WT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "N", "=", "3", "biological", "replicates", "of", "WT", "." ] } ]
PMC9014716	The mushroom Trametes robiniophila Murr (Huaier) is used as a traditional Chinese herbal medicine approved by the State Food and Drug Administration of China and widely employed for the treatment of multiple cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11075223	In addition, only IFA is used as an indicator component in the content determination of Cimicifugae Rhizoma in ChP , while a single component is difficult to fully reflect the quality of Cimicifugae Rhizoma and does not conform to the overall concept of TCM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739484	This figure illustrates the expression and prompter methylation analysis of MMPs in skin cutaneous melanoma (SKCM) and control cell lines using the RT-qPCR technique.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11694625	It is worth mentioning that 3b and 3c displayed more potent antiproliferative activity against MCF-7 cells than 5-FU and Erlotinib with IC50 values of 7.016 μM and 7.05 μM, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746942	p < 0.05; p < 0.01; p < 0.001; ***p < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11743316	Ovarian cancer is linked to numerous levels and multiple parameters of pathological alterations by employing a variety of genes, proteins, and metabolites separately or in combinations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In a survey of 165 patients, 55% said that they were skeptical about vaccination safety, and 58% said that they were concerned about unintended side effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10858941	It is also concerning that certain drugs could be efficient for humans, and yet have not been included in clinical trials because of inconclusive results in animal models [24–26].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7887261	The familial cases were selected from high-risk LC families with at least two first-degree relatives affected with LC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "familial", "cases", "were", "se...
PMC11665584	In parallel, H3K4 trimethylation (H3K4me3) CUT&Tag-Seq, which marks open chromatin at the promoter region, illustrated characteristic peak binding immediately upstream of and at the TSS (Supplemental Figure 6A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9559528	Unfortunately, the patient was unable to recall additional details about his diagnosis and workup.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unfortunately", ",", "the", "patient", "was", "unable", "to...
PMC11607638	Reverse transcribed cDNA was used as template to detect changes in gene expression by qPCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reverse", "transcribed", "cDNA", "was", "used", "as", "temp...
PMC11441402	These results use the same raw data as Figure 4 but without consideration of Tz, therefore data can only be plotted as a percentage of untreated control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Aims: Comparison of the process of maintenance therapy, efficacy, and prognosis between RAD induction and PAD induction in patients in previous clinical studies.

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PMC11730311

Peptides were quantified based on the extracted ion chromatogram (EIC) of their highest isotopic peak.

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PMC9429973

IV glofitamab was then given as step-up doses on Day (D) 1 (2.5mg) and D8 (10mg) of C1 and at the target dose (30mg) on D1 of C2–12 (21-day cycles).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11655498

The emergence of numerous innovative technologies and methodologies enables a deeper understanding of the mechanisms underlying EBV latency and reactivation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "emergence", "of", ...

PMC11401358

Flow cytometry detection of ROS levels in untreated and (GAGSGA)2-treated NIH 3T3 cells incubated with H2O2. (

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PMC10123657

After 24 h of co-culture, 1513 and 67 proteins from human and mouse origin, respectively, were identified in CCRF-CEM cells.

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PMC11711063

ZG16B and Bex + Carv antagonize in defining cell identity, and suppressing or inducing basal characteristics, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ZG16B", "and", "Bex", "+", ...

PMC11597291

The nCGO-PEG(10 kDa) particles were labeled with FITC, which was conjugated through EDC chemistry.

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PMC11718809

The GC content ranged from 50.51% to 53.23%, and the Q30 content from 96.35% to 96.53% (Table 1).

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PMC11502066

The data presented in this review article clearly show that flavonoids can exert important anticancer effects through acting on different types of GPCRs, highlighting these natural polyphenols as potential drug candidates for the treatment of human malignancies.

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PMC3681794

Drug response was assessed using the sulphorhodamine-B (SRB) assay.

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PMC11718809

These DECs were derived from four host genes: retinoblastoma binding protein 8 (RBBP8), tetratricopeptide repeat, ankyrin repeat, and coiled-coil containing 1 (TANC1), sorting nexin-29 (SNX29) and tousled-like kinase 2 (TLK2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10988555

Taken together, our data suggests that our cobalt complexes can interact with DNA possibly by a groove binding mechanism (Figure S18) but particularly, can induce DNA damage (cleavage) (Figures S12–S16).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10994876

Despite advancements, most techniques focus on specific genes to address individual cellular challenges.

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PMC7504302

Specifically, triple knockout animals developed highly invasive and proliferative tumors, predominantly with sarcomatoid histologic subtype, recapitulating the human MPMs.

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PMC11806818

Key targets in liquid biopsy include circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), extracellular vesicles (EVs), and circulating tumor RNA (ctRNA) [2–5].

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PMC10878518

The GFP gene expression cassette under the control of cytomegalovirus promoter was inserted into the E3 region of OBP-301 .

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PMC8584666

In the future, sGPI-80 released into the blood may be a useful index for examining chronic inflammation and immunosuppression in cancer patients.

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PMC8345486

Among them, compound 23 showed the highest accumulation, and compound 14 showed the lowest accumulation, which corresponded to their toxicity potential.

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PMC11539788

Novel insights into the driver genes of BCa aggressiveness could provide better therapeutic modalities.

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PMC10743717

The Human Genome Organization (HUGO) announced in 2007 that HSD17B10 serves as the official symbol of this gene and thus the terminology of the gene product is type 10 17β-hydroxysteroid dehydrogenase .

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PMC11792090

The CAR-T cells were then rechallenged with 786-0-luc cells for a total of four rounds.

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PMC9429973

Applying breakpoint-spanning PCR, validated aberrations were used as markers for assessment of minimal residual disease (MRD) in selected cases during AML treatment.

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PMC11537649

Lnc NEAT1 was knocked down in A375 cells with miR-152-3p inhibitor or CDK6 overexpressing. (

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PMC9960565

In the ¹H-NMR experiments, the signal of deuterated water (D2O) was used as an internal reference, while potassium tetrachloroplatinate (II) was used as the external reference in the ¹⁹⁵Pt-NMR experiments.

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PMC11306019

Correlation between number of VDMs in 11 polyphenols and their AI values.

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PMC9429973

It is well known that ABO antigens are expressed on respiratory epithelial cells, however these antigens called type-1 antigens which differ from type-2 antigens expressed on red blood cells.

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PMC5308810

This can be a useful approach to study the functional roles and targeting benefits of a particular or multiple CSC populations.

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PMC10218459

The treatment was performed similarly to the TUNEL assay.

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PMC11342785

Human FUS (residues 1–214) was amplified by PCR using pHR-FUSN-mCh-Cry2WT (Addgene #101223).

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PMC9429973

11-colour flow cytometry was performed after cells were activated with H2O2 for 15 minutes, due to its activity as a potent phosphatase inhibitor and cells were analysed for phosphorylation of ZAP70 as a surrogate of TCR signalling and STAT5.

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PMC11681005

These results suggest that DNA hypermethylation might not necessarily be transcriptionally suppressive.

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PMC11684297

The zeta potential was − 12 mV, which shows that the synthesized ZnO-NFs were relatively stable (Fig. 1c).

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PMC11697065

1Generation and Characterisation of Stable CHO Cell Pools Expressing Different Antibody Format Biotherapeutics.

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PMC9429973

Image: Summary/Conclusion: Parsaclisib was generally well tolerated and resulted in Hgb improvements as early as Wk 2 that increased over 12 wk of treatment and were sustained through the extension period.

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PMC11783017

Degradation rate of hydrogels at different H2O2 concentrations.

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PMC11310713

After 4 to 5 weeks, when serum sex hormone levels reached a stable baseline, the OVX rats had a GTB injection (n = 9) or 4 types of pharmaceutical hormone delivery.

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PMC11707577

The Hydra Elongation factor 1‐alpha (Ef‐1α) was used as reference gene.

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PMC11599565

At least 20 “twin” cells and a proportional amount of surrounding normal cells were collected for single-cell RNA isolation.

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PMC9429973

These results do not support different treatment strategies for EN disease; however, due to limited sample size the role of RT and the prognostic impact of specific locations cannot be fully ascertained.

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PMC9429973

Glucarpidase, approved for use in pts with delayed MTX clearance, is a zinc-dependent enzyme, which rapidly cleaves MTX into non-toxic metabolites and offers an alternative route of MTX elimination.

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PMC11422497

Primary antibodies were then applied to the membranes and allowed to incubate overnight at 4 °C, facilitating specific binding to target proteins.

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PMC8973085

To illustrate the potential binding mode of pyridine derivatives into the active sites of the three types of tumor cells we investigated (HCT-116, HepG-2 and MCF-7), a docking study of the most active derivatives against each cell type using MOE (2014.0901) (Molecular Operating Environment software).

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PMC11609529

This dependency suggests that ES-2 cells are susceptible to inhibitors targeting the YAP1/TEAD transcriptional program.

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PMC11665555

Among other genes significantly altered by the OXCT1 KO, a member of the epidermal growth factor receptor (EGFR) family, ERBB2, was downregulated.

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PMC9429973

Most patients presented ITD FLT3 (80%), 56% were refractory and 44% were relapsed (CR1 duration ≥6 months in 60%).

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PMC11468365

Fig. 8The of sensitivity score over the 7 tissue types of the cancer cell line The of sensitivity score over the 7 tissue types of the cancer cell line The top ten MultiComb predicted sensitivity scores are compared with actual sensitivity scores in Fig. 9.

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PMC11519583

The stained cells were rinsed with 60% (v/v) isopropanol and then incubated in 100% isopropanol for 20 min to extract the Oil Red O incorporated into adipocytes.

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PMC10253553

Pathways induced by VEGF include mTOR .

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PMC11618052

C NMR (100 MHz, δ ppm DMSO-d6): 160.86, 156.49, 147.32, 143.95, 135.77, 135.37, 135.05, 133.03, 130.06, 129.92, 129.61, 129.51, 126.64, 126.30, 126.18, 122.29, 121.83, 119.71, 26.66.

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PMC11568601

was used to enhance the staining intensity.

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PMC11597291

The only exception was the nCGO-PEG(2 kDa) particles, which showed an increase in size after a week’s time storage, assuming a value around 300 nm, which, however, remained essentially constant for the remaining storage time (Figure 2A,B).

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PMC11532793

With bootstrap sampling, kallisto was approximately 45% faster than Salmon, taking between 5 and 12 min to quantify libraries with 25 and 100 million reads pairs, respectively (Supplementary Table S1).

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PMC9429973

Only one subject in the 55 mg group experienced DLT (Grade 3 QT prolongation), and MTD had not been reached.

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PMC11754784

b The logic flowchart and truth table of DNP1.

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PMC9429973

17 patients developed CMV-DNAemia in haplo-cord transplant and 9 in haplo patients.

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PMC11301242

Conversely, none of the normal blood samples exhibited valid amplification (Fig. 1B; Supplementary Fig. 1C; Supplementary Table 2).

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PMC11721096

The obtained A. sparsifolia and C. arabica extract was prepared as a 1 mg/mL solution designated as S0.

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PMC7504302

The siRNA library used in this work consisted of nine sub-libraries, namely, ion binding, ion channel, kinase, membrane transporter, nucleic acid binding, phosphatase, receptor, transcription factor, and transporter, culminating to 8589 siRNAs in total.

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PMC11271800

It exerts anti-tumor activity by directly killing GIST tumor cells and indirectly affecting immune cells, especially in patients with large, difficult-to-resect tumors, locally advanced tumors, and post-operative adjuvant therapy.

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PMC11541241

In contrast, the FATC domain was not identified in the FoTOR2 (Figure S1A).

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PMC11036064

Consistent with this, we have shown that the combination therapy of temozolomide with ectopic expression of 10 pmol hsa-miR-34a-5p is superior to monotherapy with temozolomide and mono-therapy with 10 pmol hsa-miR-34a-5p ectopic expression in terms of inducing cytotoxicity (both P-values <0.0001) (Figure 7E(Fig.

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PMC11285179

Western blot experiments revealed that the expression of CCR3 was significantly higher than that of CCR10 in pericytes, suggesting that CCR3 likely plays a predominant role in mediating CCL28 signal transduction within pericytes (Fig. 2F).

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PMC11683240

Here, only two residues showed interactions with more than 50% of the evaluated time LYS310 and ASN314, and these were through weak forces (van der Waals, hydrophobic).Figure 11Energy decomposition of the interaction per residue in the last 10 ns of simulations.

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PMC11678130

Apoptosis is usually characterized by a series of rearrangements within the intracellular compartment that affect the nuclei and the cytoskeleton: nuclear chromatin becomes condensed and is fragmented into apoptotic bodies, whereas tubulin and F-actin constrict and form thick bundles .

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PMC11555465

Zhou et al (33) report that T. gondii rhoptry protein 18 reduces human glioma cell apoptosis via a mitochondrial route, targeting host cell P2X1.

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PMC11670407

f Representative images of immunofluorescence staining for the colocalization of GPX4 and OTULIN in U2OS cells (scale bar: 20 μm).

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PMC11515150

The humanized VHH fragments were subcloned into E. coli TG1 strains, and tagged with 6xHis tag for purification.

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PMC8759873

Lalif successfully cloned the VHL gene in 1993 and confirmed that the root cause of VHL disease is VHL gene inactivation, and VHL exists in more than 98% of VHL diseases.

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PMC11544122

Bars represent the mean ± SD from five independent experiments.

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PMC11657695

The whiskers indicate the fifth and the ninety-fifth percentiles.

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PMC10604092

Moreover, we measured the mRNA levels of muscle-specific degradation factors associated with muscle atrophy in cancer cachexia .

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PMC8389560

It is known that in astrocytes, which, much like glioblastoma, are also electrically excitable cells, an increase in [Ca]i causes the release of glutamate and other transmitters, primarily ATP .

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PMC11786600

However, when the PF-127 content of PED3 reached 20%, the contact angle of PED3 slowly decreased.

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PMC11462929

We then tried to verify whether BENC‐CNA is associated with higher MYC expression in BCP‐ALL cell lines using NALM6 as a control.

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PMC9429973

There was no difference in the proportion of cell subtypes and expression of exhausted biomarkers between CD7- and CD7+ T cells.

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PMC10887351

However, recent studies reported that β3-AR-KO increased the high fat diet, inducing more severe obesity, with WAT hypertrophy and inflammation, compared to wild-type mice .

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PMC10978090

2 3 Another strategy is to combine intraoperative unfractionated heparin (UFH) with a potent parenteral antiplatelet agent that prevents HIT-mediated platelet aggregation during cardiopulmonary bypass (CBP).

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PMC6461034

Divide a volume of cell suspension expected to yield 10–12 mg protein over 50‐ml tubes.

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PMC11138140

While we attempted to start our digital holographic imaging time-course experiments soon after norepinephrine treatment, the time it took to initiate our time-lapse movies after treatment ranged from 1 to 2 h due to technical obstacles.

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PMC11721295

Samples were processed simultaneously to avoid batch effects.

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PMC11335267

Briefly, serial consecutive images of an axial slice containing the hypothalamus were obtained using nine “high b” (300 < b < 2000 s/µm) values in three orthogonal directions: Head-Foot (H-F), Left-Right (L-R) and Antero-Posterior (A-P).

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PMC11782780

Western blot analysis was employed to assess the expression of stem cell-related markers and proteins associated with the glycolysis metabolic pathway.

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PMC11679326

Further studies of AVL lectin revealed that as part of an oncolytic virus, it induces metabolic reprogramming in hepatocellular carcinoma cells by stimulating the production of reactive oxygen species (ROS).

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PMC11742290

LGR5 has been linked to angiogenesis through its role in promoting CSC, secreting angiogenic factors like VEGF, and interacting with the TME, all of which contribute to tumor vascularization and progression .

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PMC11637276

The survival analysis was performed using Kaplan–Meier plotter (https://kmplot.com/analysis/), which can assess the effect of genes of interest on survival in 21 cancer types, including pancreatic cancer.

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PMC11731614

N = 3 biological replicates of WT.

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PMC9014716

The mushroom Trametes robiniophila Murr (Huaier) is used as a traditional Chinese herbal medicine approved by the State Food and Drug Administration of China and widely employed for the treatment of multiple cancers.

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PMC11075223

In addition, only IFA is used as an indicator component in the content determination of Cimicifugae Rhizoma in ChP , while a single component is difficult to fully reflect the quality of Cimicifugae Rhizoma and does not conform to the overall concept of TCM.

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PMC11739484

This figure illustrates the expression and prompter methylation analysis of MMPs in skin cutaneous melanoma (SKCM) and control cell lines using the RT-qPCR technique.

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PMC11694625

It is worth mentioning that 3b and 3c displayed more potent antiproliferative activity against MCF-7 cells than 5-FU and Erlotinib with IC50 values of 7.016 μM and 7.05 μM, respectively.

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PMC11746942

p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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PMC11743316

Ovarian cancer is linked to numerous levels and multiple parameters of pathological alterations by employing a variety of genes, proteins, and metabolites separately or in combinations.

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PMC9429973

In a survey of 165 patients, 55% said that they were skeptical about vaccination safety, and 58% said that they were concerned about unintended side effects.

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PMC10858941

It is also concerning that certain drugs could be efficient for humans, and yet have not been included in clinical trials because of inconclusive results in animal models [24–26].

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PMC7887261

The familial cases were selected from high-risk LC families with at least two first-degree relatives affected with LC.

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PMC11665584

In parallel, H3K4 trimethylation (H3K4me3) CUT&Tag-Seq, which marks open chromatin at the promoter region, illustrated characteristic peak binding immediately upstream of and at the TSS (Supplemental Figure 6A).

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PMC9559528

Unfortunately, the patient was unable to recall additional details about his diagnosis and workup.

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PMC11607638

Reverse transcribed cDNA was used as template to detect changes in gene expression by qPCR.

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PMC11441402

These results use the same raw data as Figure 4 but without consideration of Tz, therefore data can only be plotted as a percentage of untreated control.

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