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OTAR3088
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BioData-CellLine_annotated

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PMC4270159
In this study, Wilson and colleagues examined several cancer cell lines for ligand-mediated drug resistance (Wilson et al., 2012).
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PMC10907726
Among them, the expression of PD-L1 and PD-1 checkpoints was activated for tumor inhibition.
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PMC9512971
Convenient oral drugs that can be prescribed to patients recuperating at home or other outpatient settings are also needed.
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PMC9503685
CSA-13 also showed a highly effective inhibitory effect at a concentration of 10 mg/L at which it caused a three-log decrease at each time point, compared to the control group (Figure 3).
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PMC11762280
The relative protein levels of the above proteins were compared with ACTB as quantification (n = 3).
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PMC9878562
In line with the induction of cell-to-cell-induced migration, CXCL12 stimulated in VAL-wt a significant over background (~ 10 pg/mL) release of LTB4 ( Figure 6D ).
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PMC11747949
Angiogenesis proteins are also affected differentially.
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PMC11658074
2AT-derived extracellular vesicles (AT-EVs) can alleviate skin photoaging caused by UVB.
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PMC11723210
The fused complex amplitude is used as the initial input for the multi-wavelength phase recovery algorithm to obtain an accurate phase reconstruction.
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PMC9065483
Supernatant was collected 48 hpi and viral titer was assessed by plaque assay (n = 3, mean ± SEM; ∗∗p < 0.01 by one-way ANOVA). (
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PMC9429973
Unexpectedly, age- and sex-normalized quality of life and general life satisfaction summary scores were significantly higher in AML-LTS (p<.001) compared to adults without the diagnosis of AML.
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PMC6642070
HMGCR protein assessed by western blotting. (
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PMC10907726
Total RNA was extracted and reverse transcribed into cDNA and PCR analysized by the ReverTra Ace qPCR RT Kit (TOYOBO, Japan), SYBR Green Real-time PCR Master Mix (TOYOBO, Japan) and QuantStudio Dx (Invitrogen, Thermo Fisher).
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PMC9429973
Three patients died before treatment (12%) and 22 patients received chemotherapy.
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PMC11334037
A: Tumor growth in xenografted nude mice; B: Tumor volumes in sh-insulin-like growth factor 2 (IGF2)-gastrointestinal stromal tumors (GIST)-T1 mouse xenograft models treated with imatinib; C: After 35 d, the mice were killed and the tumors were weighed; D: Assay of IGF1R, p-IGF1R, PI3K, AKT, and p-AKT in tumor tissue b...
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PMC11489351
The z-score is calculated as described above.
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PMC11377827
n = 3 biologically independent samples, mean ± sd.
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PMC9143157
MTT assay was carried out for evaluating the cytotoxicity.
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PMC6684588
Mice were anesthetized with isoflurane (Fig. 4) or sodium pentobarbital (Figs. 3, 5; 80 mg/kg, i.p.).
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PMC5874706
The dose-response curve was determined, and the concentration inducing hemolysis in 50% of the erythrocyte population (HC50) was subsequently calculated .
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PMC11643491
In this case, 6-coumarin serves as a drug surrogate, illustrating the ability of the particles to retain a compound throughout the entire fabrication process, as seen by the fluorescence in the images.
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PMC11066331
Standard processing of mass spectra involved several steps: briefly, the initial quality control, transformation and smoothing (Savitzky-Golay filter) with halfwindowSize = 100, baseline correction (statistics-sensitive non-linear iterative peak-clipping, SNIP) with 500 iterations, intensity calibration (∑Xi = 1, where...
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PMC9429973
In fact, high LSCs number and active LSC self-renewal programs are related to poor therapy response and adverse outcome in AML.
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PMC8728081
In this section, the Ayurvedic process has been observed and documented in terms of changes in the physicochemical properties of the materials involved during the Rasasindura preparation.
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PMC9429973
This MPN subgroup at high risk for progression to severe COVID-19 disease should be prioritized for antiviral therapy, even in the ambulatory setting.
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PMC9844987
Epstein-Barr virus immortalized LCLs (Supplementary file 1) were obtained from the NIGMS Human Genetic Cell Repository at Coriell Institute for Medical Research.
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PMC11612794
To distinguish the cell cycle timing of Mis12C recruitment to CENP-C and CENP-T, we examined Mis12C localization at kinetochores in CENP-C cells (wild-type chicken DT40 cells) and CENP-C cells lacking the Mis12C-binding region of CENP-C (aa 1–73; Figures 1A and S1A).
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PMC11766350
In this case the inclusion of the riboswitch sequence in the transgene did not interfere with expression in the target cells in mice .
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PMC9398137
In this study, we used specific MCL1 inhibitor and demonstrated that combination of S63845 and venetoclax is synthetically lethal in BCL2-positive DLBCL.
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PMC11190238
Although EMT occurs in a context-dependent manner, therein lies core regulatory networks present in both physiological and pathological conditions which are previously summarized in recent reviews, and the checkpoints at each transitional phase of the EMT spectrum could be governed by different EMT-TFs of the core regu...
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PMC11794847
The transwell assay also mirrored this trend, indicating that the invasive and migratory capabilities of the lung cancer cells were curtailed in the presence of the GPT2-overexpressing, HVEM-deficient T cells (Fig. 7J–M).
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PMC11519583
MPs can be identified as Sca-1-positive and CD31-, CD45-, and SM/C-2.6-negative cells.
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PMC9429973
Response rates at six months after switch (the primary endpoint) varied significantly among patients in different clinical settings (Figure 2).
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PMC11672881
First-strand cDNA was made from 1 µg of the extracted RNA using the SuperScript III First-Strand cDNA Synthesis System (Invitrogen, Grand Island, NY, USA).
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PMC11739504
The results imply that even though cilia formation was saturated in Kat2b-depleted cells to the same extent as in the control cells, ciliary function may be damaged.
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PMC11224206
For example, the major impact of a reduction in ambient temperature will be a diminished rate of metabolic reactions .
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PMC11678368
For trans-[PtCl2(5ClL)2], the energy difference between complexes formed from the cis and trans conformers of 5ClL is 4.42 kcal/mol (based on Emin.),
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PMC9351137
All results are expressed as mean±SD values from three independent replicate experiments.
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PMC11731161
However, functional experiments in their study failed to provide additional support for the relationship between ASB8 expression and sensitivity to SEL.
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PMC11468365
So, the dataset consists of 38 unique drugs that are combined to get 23,052 drug combinations.
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PMC9318744
The images were processed by Celigo Image Software (Nexcelom Bioscience, Lawrence, MA, USA, version 200-BFFL-5C) or Meta-Xpress Software (Molecular Devices, San Jose, CA, USA, version 4.0.0.43).
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PMC11768927
They also observed that combining cisplatin with rVSV-F reduced the tumor burden and increased survival in vivo.
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PMC6600592
Colorless liquid, yield 80.7%.
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PMC9545714
Specific benefits of lycopene and/or β‐carotene include protection against UV‐induced erythema and sun damage, , , reduced oxidative stress, and antioxidant/anti‐inflammatory activities.
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PMC11045125
Human BLs with Wp-restricted latency are infected with naturally occurring EBV strains containing deletions that remove the EBNA2 gene, and a portion of the EBNA-LP protein.
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PMC11519567
Open the temperature control module of the Zeiss 900 instrument to provide a suitable environment for the cells.
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PMC11401358
This process was repeated three times to ensure that the sericin proteins were completely removed.
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PMC11349530
Generally, the primary adverse effects of anti-IL-6/IL-6R antibodies are associated with bacterial infections (45).
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PMC9622879
Energy flows in a smart home with RES and ESS.
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PMC9429973
This is even more relevant when combining DNA methyltransferase inhibitors with histone deacetylase inhibitors.
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PMC11082662
ACER2, alkaline ceramidase 2; SMPDL3B, sphingomyelin phosphodiesterase acid-like 3B; CCK-8, cell count kit-8; OD, optical density; GFP, green fluorescent protein.
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PMC9429973
Identified resistance mutations included alterations in BTK, PLCG2, and BCL2 genes, which led to changes in therapy from a BTK inhibitor to venetoclax or vice versa.
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PMC11248911
Anal.
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PMC11470999
Previous studies have shown that patients taking antipsychotic drugs capable of crossing the BBB have a lower incidence of cancer, indicating the potential of these drugs in cancer treatment. ,
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PMC10810426
Perhaps the relatively low innate immune response to retroviruses compared to other RNA viruses is because of the rapid movement of RTCs to the nucleus in sentinel cells, thereby avoiding cytoplasmic detection.
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PMC11286266
Additionally, a XBP1 band (280 bp) was observed.
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PMC9681981
Then, fixed cells were stained with 1/20 diluted commercial Giemsa solution for 10 min, washed with distilled water, and observed under an inverted microscope (Nikon, USA).
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PMC10452486
A complementary report suggests that HLA-F variants act as ligands for KIR3DS1.
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PMC11786767
In addition to COS-7 cells, we examined mouse neuroblastoma Neuro-2A cells to investigate the distribution of nuclear lipids.
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PMC11751675
Over 500 publications have documented its effectiveness as a biologically active substance, highlighting its potential therapeutic applications.
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PMC4485648
In many tumor types, including ovarian carcinoma, hypoxia supports development of resistance to many currently used chemotherapeutic agents (4,5).
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PMC9479186
The tumorigenesis of shNDUFC1 group was significantly slower in SK-Hep-1 and Bel-7404.
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PMC11748335
To explore the alterations of long LOCKs in tumors, we analyzed epigenomic data for ESCC and BRCA cells, alongside their corresponding normal cells, from the GEO database.
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PMC9712534
Values of DMSO-treated samples were arbitrarily set 1, and average values of relative intensities of western blot bands were calculated (n = 3; bar, SD).
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PMC11531735
Data represents mean ± S.D. * indicates statistical significance and was calculated using Student t test (*p < 0.05).
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PMC11628904
Successful tissue repair requires the coordinated migration of keratinocytes, , and we previously found that burn injury induces dysregulated keratinocyte migration compared to mechanical tissue damage in zebrafish.
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PMC11412752
Stimulator of interferon genes (STING) is a crucial regulator of the host's innate immune response to viral infections, while its role in bacterial infections remains controversial.
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PMC8759873
786-0 cells were trained in RPMI1640 medium consisting 100 g/ml penicillin >100 g/ml streptomycin and 10% fetal bovine serum in a 37°C, 5% CO2 incubator.
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PMC5574817
Specifications TableTableSubject areaPharmacology and ToxicologyMore specific subject areaStable transfection, RT-qPCR and Western Blot analysisType of dataFigures, text fileHow data was acquiredCFX96™ Real-Time PCR Detection System (Bio-Rad Laboratories, USA), ChemiDocXRS Imaging System (Bio-Rad Laboratories, USA)Data...
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PMC9429973
A total of 140 patients from 13 medical Russia clinics were included from February 2015 to June 2021.
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PMC11422150
Therefore, increased serum NO concentration suggests an exacerbation of inflammatory reactions.
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PMC9429973
Median follow-up was 4.0 yrs.
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PMC6102174
Swertia patens (Xiejing Zhangyacai), mainly distributed in Yunnan and Sichuan provinces of China, is used as a folk medicine to treat hepatitis in folk.
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PMC9429973
In the IM DISC phase, 58 of 131 pts (44.3%) experienced molecular relapse with a median onset of 3.53 months, thus the remaining 73 pts achieved TFR1 (55.7%): The mRFS rate at 12 months was 56.8% (95% CI, 47.8-64.8 %).
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PMC11534377
This is shown by the presence of rounded, balloon-like projections that protrude from the cells, aligning with the regions where the actin cortex is damaged or missing.
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PMC11495567
(1:3000) were purchased from Cell Signaling Technology (Danvers, MA, USA).
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PMC9532503
However, although these glycol-engineered antibodies have higher potency for the targeted effector function, they display weaker potency for the remaining effector functions.
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PMC4695073
The phenomenon may result from the different cycles of platinum-base chemotherapy between CCRT treatment group and IC+RT group (4.53 cycles vs. 2.24 cycles).
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PMC11638764
The maximum number of missed cleavages was set to 2.
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PMC5916734
Recombinant FIX within the BeneFIX drug (Wyeth, USA) was used as an activity reference standard.
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PMC10809689
mTORC can act as an amino acid sensor and after the amino acid glutamine enters into the AML cell, it triggers (3) the pathway of glutamine degradation (glutaminolysis) by the enzymes GLS and GDH which respectively converts Gln to Glu and Glu to α-KG in mitochondria of leukemic blast.
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PMC11755624
In this review, we will discuss the role of lncRNAs in the pathophysiology of psoriasis.
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PMC11345828
LCMS Method 1: RT = 2.289 min, MS (ESI): mass calcd for C47H51Cl2N5O7, 867.3, m/z found 867.9 (M + H).
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PMC8740518
Low cholesterol may not be a risk factor for cancer, rather it may be a sign of undiagnosed cancer (Tanne, 2007).
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PMC11098378
After three, 5 min washes with PBS-T (PBS, 0.1% Tween; S4 Table), membranes were incubated in secondary antibody conjugated to an IRDye (LI-COR; S4 Table) for 1 h followed by two, 5 min washes in PBS-T and one 5 min PBS wash.
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PMC11451829
In a previous study, we demonstrated the development of a pterygium-like lesion 7 days after the injection of fibroblasts and extracellular matrix in a rabbit animal model.
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PMC11657695
Furthermore, in the ES cell lines used, the number of GGAA microsatellites repetitions is between 12 and 16, strengthening a previous study that proved that four or more GGAA repetitions activates EWS::FLI1-regulated genes .
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PMC9429973
Numerous signalling pathways have been described that regulate quiescence.
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PMC10674574
Transparent filters are recommended for monitoring the differentiation process in an inverted or confocal microscope .
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PMC9429973
Most used targeted drugs were ITKs (51.1%), anti-CD20 other than rituximab (16%), BCL2 inhibitors (7.3%) and lenalidomide (7.9%).
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PMC11711066
After 72 h, the cells are stimulated again, and 72 h later, cell proliferation is evaluated using the MTS assay (*P < 0.05). (
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PMC9927933
The Kaplan-Meier Plotter database (https://kmplot.com) (58) and the Human Protein Altas (https://www.proteinatlas.org) were used to analyze the correlation between the mRNA/protein expression levels and the prognosis of lung cancer patients.
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PMC9100622
The first strategy identified the mevalonate pathway, including HMGCR and HMGCS1, which encode the two rate-limiting enzymes of this pathway, as a major target of EGR2, while the latter identified statins, which are well-known inhibitors of HMGCR, as major cytotoxic compounds.
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PMC11750712
CAR expression was assessed by staining with aCD3-PE/Cy7 (317334, BioLegend) and QBend10 APC (FAB7227A, R&D System).
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PMC9429973
Finally, we demonstrated the in vivo efficacy of CHZ868 in PAX5::JAK2, ATF7IP::JAK2 and ZEB2::JAK2 patient-derived-xenografts.
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PMC11705547
In one preclinical study, CAFs induced cisplatin resistance in bladder cancer cells through exosomal miR-146a-5p , which activated the STAT3 and mTOR signaling pathways by targeting ARID1A and PRKAA2 .
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PMC10858941
B Higher expression of HIF-1α in different glioma types, including GBM, compared to non-tumour (Rembrandt dataset; p < 0.001).
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PMC11359735
However, the predicted ω-site Cys residue and the 23 amino acids downstream of it, which comprises a single predicted tryptic peptide in all four species, have never been detected suggesting that the C-terminus of CSP has been processed in sporozoites rendering this predicted tryptic peptide undetectable.
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PMC11473750
Control-Forward primer: ACCCTGTATGCCTTCTCACT; Control-Revise primer: GTGGGAGATCATGAACATGACAA; RNF121 ChIP-Forward primer: AATGCGTTCTGGGGCTTCAA; RNF121 ChIP-Reverse primer: GCTCCCTCCACGAAAGAGTT.
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PMC11777207
Percentage of FITC cDC1s of total cells in the dLN. (
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