OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC4395774	Mice.	[ { "tags": [ "O", "O" ], "tokens": [ "Mice", "." ] } ]
PMC9841531	Certain drugs and druglike compounds have been reported to inhibit MCT1, such as benzbromarone (1) and quercetin (2), however, with rather low potency.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607638	The SK peptides are known satiety factors to inhibit food intake in other insects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "SK", "peptides", "are", "known", "satiety", "factors", "t...
PMC11411004	To investigate the effects of I-4 on monoclonal antibody-producing CHO cells in detail, we assessed changes in cell cycle phase distribution, cell viability, apoptosis rate, and cell proliferation following the action of I-4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	UV/cold shock or UV alone downregulates caspase 3, Bak, cortactin, and α-tubulin, and induces relocation of α-tubulin to the nucleus and the nuclear bubble.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	n = 5 mice per genotype, one-way ANOVA, Bonferroni’s multiple comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5", "mice", "per", "genotype", ",", "one-way", "...
PMC11703992	After identifying DDIT4 and ARHGAP15, we divided the CD4+ Memory T cells in GCA samples into DDIT4 ± and ARHGAP15 ± groups based on their expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11779960	Further, WGS and WES often result in low sequencing depth for the TCR region, leading to high noise unless validated by other methods.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11317131	Helper plasmids for mammalian expression called pCMV2 PhiC31 wt, pCMV2 HuOpt Bxb1 and pCMV2 HuOpt Pa01 encode wildtype PhiC31 (37), Bxb1 (22) and Pa01 (38) integrases, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7171147	b Western blot of FASN in ES2 cells expressing scrambled and DDR2 shRNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Western", "blot", "of", "FASN", "in", "ES2", "cells", "...
PMC10698968	The 143B human osteosarcoma cell line was obtained by ATCC and was chosen as control in each experiment as an example of an extensively studied and characterised aggressive sarcoma cell line, unless differently specified.	[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11126803	E, in A498 cells, VM formation was significantly increased when ERβ was overexpressed, but this process could be effectively reversed by sh-ZEB1.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11397654	The compounds were evaluated for their antiproliferative activity against two types of breast cancer cells, MCF-7 and MDA-MB-231, and a human normal epithelial cell line PNT1A.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11420784	Western blotting result showed a 0.87-fold increase of LC3-II in the isolated fraction from ΔpldA-infected 5637 cells compared to WT infected (Figure 3D), indicating PldA inhibits autophagosome formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10530622	Hippuric acid is a protective metabolite since it increases the solubility of urinary oxalate .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hippuric", "acid", "is", "a", "protective", "metabolite", "since", ...
PMC9429973	Idiopathic acquired aplastic anemia (AA) is a bone marrow (BM) failure disease characterized by pancytopenia and a hypoplastic fatty marrow.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11348300	Furthermore, to facilitate comparative analysis, HS values were normalized to their maximum value in each specimen, corresponding to the HS value after the mice were killed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Clinical characteristics are shown in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "characteristics", "are", "shown", "in", "Table", "1", "." ] } ]
PMC8623816	All R. solani strains were cultured on potato dextrose agar (PDA) medium at 28–30 °C and were stored on PDA slants at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9436459	Most of the dehydroprenylsanggenonflavone type (Type F) MDAAs (ten compounds) were isolated from five Morus plants (M. alba, M. bombycis, M. cathayana, M. mongolica, and M. nigra), and simple or other dehydroprenylphenol type (Type H) MDAAs (five compounds) were distributed in five species including M. alba, M. macrour...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, its presence in MM patients without AL is extremely rare and there are few cases described in the literature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "i...
PMC10237474	F-G) As in (D), but with (F) Protein 7 and (G) Protein 8 and their respective zoom-in analytical SEC traces. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A. Bock, K. Poonsombudlert, M. Larson, J. Gile, R. Tawfiq, S. Maliske, M. Maurer, J. Cerhan, X. Andrade-gonzalez, A. Saliba, J. Paludo, D. Inwards, S. Ansell, T. Witzig, T. Habermann, B. Link, S. Ayyappan, G. Nowakowski, U. Farooq, Y. Wang Division of Hematology, Mayo Clinic, Rochester; Division of Hematology, Universi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604768	Upon GPCR activation by receptor agonists, these G protein complexes initiate distinct downstream signaling cascades.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Upon", "GPCR", "activation", "by", "receptor", "agonis...
PMC10667689	Further inquiries can be directed to the corresponding author.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "inquiries", "can", "be", "directed", "to", "the", "corresponding", "author", "." ] } ]
PMC11204465	This review attempts to give a comprehensive summary of progress on the chemical structural features, synthesis, and bioactivity of sterigmatocystins and aflatoxins reported from 1954 to April 2024.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10154881	Our rMV‐SLAMblind cancer therapy activated both ot these immune cell subsets, leading to the enhancement of therapeutic efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "rMV‐SLAMblind", "cancer", ...
PMC11348300	PpIX fluorescence absorption and emission spectra overlapped on oxy- and deoxyhemoglobin absorption spectra. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PpIX", "fluorescence", "absorption", "and", "emission", "spectra", "ov...
PMC10589262	PF was used at a concentration of 30 µM commonly used in previous in vitro and in vivo studies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PF", "was", "used", "at", "...
PMC11727907	On the other hand, it is well known that the lower activity of PKM2 stimulates the PPP, promoting the synthesis of macromolecules and inhibiting the production of ROS .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5716223	Indeed, we demonstrated a significant enhancement of JNK phosphorylation after 15′–30′ min from NGF (20 ng/ml) supplementation in L6C5 myoblasts grown under serum starvation (p < 0.05) (Fig. 1d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11551844	Peak 7 was isolated by preparative HPLC-DAD and was characterized by H-NMR spectroscopy (Fig. 4S†).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Peak", "7", "was", "isolated", "by", "prepa...
PMC11397654	The supramolecular aggregate of 46 and 47 can be thus potentially used in targeted photodynamic therapy against cancer cells to inhibit unwanted cytotoxicity of the drug.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11682172	Mass spectrometry-based proteomics revealed significant alterations in the expression of 35 proteins by the breast cancer cell lines upon T cell contact.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mass", "spec...
PMC11670407	We then investigated the mutual localization of GPX4 and OTULIN by immunofluorescence colocalization in U2OS cells under normal conditions and found that OTULIN and GPX4 were mainly localized in the cytoplasm; in the cytoplasm, the fluorescence of GPX4 and OTULIN overlapped (Fig. 4f).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10237474	Moreover, they share the highest similarity to human cells and thus produce proteins with human-like PTMs [2–4].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "they", ...
PMC9429973	inducible KD/KO systems.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "inducible", "KD/KO", "systems", "." ] } ]
PMC9429973	Data analysis was performed using the program IBM SPSS Statistics 26® Results: It was included 47 patients [42,6% male (n=20), 57,4% female (n=27)], median age at diagnosis of 70 years (61-81), median Eastern Cooperative Oncology Group performance status (ECOG PS) 1 (0-2) and median Charlson Comorbidity Index (CCI) 6 (...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11334037	A recent case study reported that a GISTs that produced big-IGF2 also caused severe hypoglycemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "recent", "case", "study", "reported", "that", "a", ...
PMC9429973	Towards this aim, we established CRISPR Cas9 dropout screens in PDX models of acute leukemias in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Towards", "this", "aim", ",", "we", ...
PMC9429973	Overall response rate (ORR) in those with 1 prior therapy was 88% (n=14; 95% CI 61.7–98.4) in those with blastoid/pleomorphic disease (complete response [CR] in 50%, n=8) versus 81% (n=35; 95% CI 66.6–91.6) in those without blastoid/pleomorphic disease (CR in 47%, n=20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670407	g, h Tumor volume and tumor weight were measured and analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", ",", "h", "Tumor", "volume", "and", "tumor", "weight", "were", "measur...
PMC9429973	Certain mutations were acquired or lost during Richter transformation in some patients, indicating clonal evolution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Certain", "mutations", "were", "acquired", "or", "lost...
PMC10994876	The cells were then detached using trypsin, washed with ice-cold PBS, centrifuged, and re-suspended in 100 μL of binding buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11544122	BRET curves were fit by nonlinear regression (log(agonist) vs. response (three-parameters)) using GraphPad Prism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BRET", "curves", "were", "fit", ...
PMC11693599	In a previous study, we established a method for isolating CSCs from epithelial ovarian cancer cell lines (26).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "a", "previo...
PMC10747160	As described in Section 2.6, the levels of p24 in each well were measured on a ClarioStar Plus microplate reader set to 450 nm (BMG Labtech, Ortenberg, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8389560	The PCR procedure consisted of 94 °C for 2 min followed by 35 cycles of 94 °C for 1 min, 60 °C for 30 s, and 72 °C for 30 s. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as an internal control for normalization and results were expressed as 2–∆(∆Ct).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615743	Moreover, given the antinuclease, nontoxic, and low immunogenic nature of mirror‐image oligonucleotides, L‐DNA and L‐RNA probes have been extensively developed for therapeutic purposes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	SUMOylation is a post-translational protein modification pathway closely related to ubiquitylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SUMOylation", "is", "a", "post-translational", "protein", "modification", "pathway", "closely", ...
PMC10778532	Moreover, we found that sunitinib treatment inhibits ZHX2 expression and induces a reduced proliferation correlating with downregulation of P-ERK.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "we", ...
PMC11543853	Cells infected by rhinovirus 2, echovirus 18, echovirus 30, and enterovirus 71 contained ruptured endosomes with openings of sufficient size to enable diffusion of the virus particles or genomes into the cytoplasm (Figs. 1a, b, 2g–j, Supplementary Fig. 1d, 2d, 3d, Supplementary Movie 1, Supplementary Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10854447	Also, those hybrids exhibit high intestinal absorbance and are non-substrate for P-gp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "those", "hybrids", "exhibit", "high", "intestinal", "absorbanc...
PMC11171319	The direct oncogenic role of HCMV following acute infection of primary epithelial cells (HMECs, OECs, and PECs) and human astrocytes is summarized in Table 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Further validation on larger and prospective clinical studies are needed C. Duane, C. Comerford, P. Murphy, P. Thornton, J. Sargent, S. Glavey, J. Quinn Department of Haematology, Beaumont Hospital Dublin; School of Medicine; Department of Pathology; Department of Haematology, Royal College of Surgeons in Ireland, Dubl...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11411131	Coexpression of SECIS binding protein 2 (SBP2) to enhance selenoprotein translation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Coexpression", "of", "SECIS", "binding", "protein", "2", "(", "SBP2", ...
PMC10891340	Mitochondria produce ROS, and mitochondrial damage can lead to the accumulation of ROS (Ma et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mitochondria", "produce...
PMC7642379	On chromosome 13, several genes associated with the cytoskeleton (BORA, MZT1, PIBF1, DACH1 and KLHL1) had a copy number gain in all progeny cell lines (Supplementary Table S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Five pts treated with TAG were bridged to a stem cell transplant (n=3 1L, n=2 R/R; Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Five", "pts"...
PMC9424261	C The ferroptosis-related metabolic axis from glucose to GSH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "The", "ferroptosis-related", "metabolic", "axis", "from", "glucose", "to", "GSH", "." ] } ]
PMC11777207	GM-CSF BMDCs were collected at day 4, spun down, and counted, and 2.5 × 10 cells were spinfected for 2 hours at room temperature in 1 ml of collected viral supernatant containing polybrene at a concentration of 15 μg/ml (Sigma-Aldrich).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394112	After intravenous injection of these cells into humanized NSG mice, we monitored the tumor growth and evaluated the organ-specific engraftment/progression period.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "int...
PMC11633763	Therefore, early diagnosis and efficient treatment are crucial to improve patients' outcome and survival rate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "early", "diagnosis", "and", ...
PMC9429973	ASXL1 mutations are correlated with higher monocyte counts, increasing CD34 cells in peripheral blood (PB), larger spleen sizes, and higher MF grades.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The data pinpoint NF-ΚB activation as a biomarker for in vivo VEN-resistance and provide a specific biological rationale for ceasing VEN in deep response, as is currently being used in time-limited and explored in response-directed regimens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461833	ERVs are biomarkers of ageing, and affect various ageing-related diseases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ERVs", "are", "biomarkers", "of", "ageing", ",", "and", "affect", "various", "ageing-...
PMC9429973	63% (157/249) of patients went through an ABVD regimen treatment; only 9 patients of this group were switched to an ABVD/ABV course of treatment after receiving CMR, in accordance to PET.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8164677	Each drug was added at four doses in three wells and incubated (37°C, 5% CO2 in air) for 72 h. Cisplatin and wedelolactone were prepared in desired concentrations (0.16–20 µM for cisplatin and 0.80–100 µM for test compound) followed by addition of 100 µL of each drug in triplicate wells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Geriatric patients should be set at least age 65 or above as a cut-off level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Geriatric", "patients", "should", "be", "set", "at", "least...
PMC10713411	Furthermore, uni-Cox regression analysis among these 36 genes was conducted and the results demonstrated that 17 DEGs had significant correlations with OS (P < 0.05) of KIRC patients (Figure 2E), including 4 protective factors (HR <1) and 13 risk factors (HR >1), which were termed PRPCDGs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11119602	Following 24 h incubation, the culture medium was removed and replaced with 100 µL of fresh culture medium containing cisplatin or the other drugs tested.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11310713	As shown in Fig. 3D and E, our results were similar to those of previous studies; the body weight increases typically in OVX rats.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11589157	The final prediction yielded 18,925 protein-coding genes (with 23,783 mRNAs), comparable to the gene counts in the Nleu_3.0 (18,991 genes, NCBI Nomascus leucogenys Annotation Release 102, 2015) and H. moloch genomes (19,302 genes).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11560255	After that, they were ground into a powder.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "that", ",", "they", "were", "ground", "into", "a", "powder", "." ] } ]
PMC10772747	These findings provide a better understanding of the mechanisms of action of these compounds in inhibiting the growth of breast cancer cells and provide a strong basis for further research and development of cancer drugs using EBE as a potential agent to regulate the cell cycle in breast cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11320834	To the best of our knowledge, this is the first attempt to prepare a liposome-based delivery system for topotecan and olaparib and to evaluate the effect of their combination in a 2D model of patient-derived ovarian cancer without BRCA1/2 mutation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11578343	The inset illustrates the sinusoidal geometry of the contraction zones: the width of each zone is described by w contraction = wo + acos(ωt), where w o, a, and ω are the initial width, the strain amplitude, and deformation frequency, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543885	Match Between Runs (MBR): Enable the Match Between Runs (MBR) function to align features across different runs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Match", "Between", ...
PMC11670407	Three replications were performed for the IP-OTULIN group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "replications", "were", "performed", "for", "the", "IP-OTULIN", "group", "." ] } ]
PMC11611077	Bands were visualized using a horseradish peroxidase (HRP)-linked anti-mouse IgG secondary antibody (Cell Signaling Technology, Danvers, MA) diluted at 1:5,000 and a chemiluminescent reagent (Amersham ECL Select Western Blotting Detection Reagent, Cytiva, Marlborough, MA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684269	Hence, SGLT2 inhibits CD4 T cell metabolism, including glutamine replenishment, glycolysis, and oxidative phosphorylation (OXPHOS), thereby ameliorating renal injury.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11622247	However, no discernible difference was observed between cells treated with the probe and those subjected to mock microporation (data not shown), indicating that the fluorescence intensity was insufficient to yield meaningful results given the low efficiency of delivery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745600	Female mice required 1 or 2 tablets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Female", "mice", "required", "1", "or", "2", "tablets", "." ] } ]
PMC11434983	DMSO was present at constant concentration (0.2%) in all experimental points.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DMSO", "was", "present", "at", "constant", "concentration", "(", ...
PMC11739504	Data were collected from three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "collected", "from", "three", "independent", "experiments", "." ] } ]
PMC11742290	LGR receptors including LGR5 are known for their involvement in the regulation of stem cells and tissue homeostasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LGR", "receptors", "including", "LGR5", ...
PMC11650848	Standard deviations were tightly clustered and the methylation differences between each genotype were statistically significant by ANOVA analysis (p < 0.001, Table 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11532793	The are estimated by trended empirical Bayes from the generalized linear model residual deviances (22,23).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "are", "estimated", "by", "trended", ...
PMC9429973	Collected data was analyzed with ANOVA and CHI-squared for response in all patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collected", "data", "was", "analyzed", "with", "ANOVA", "and", "CHI-squared...
PMC9436459	MDAAs were at least found in 21 species of the family Moraceae, most of which were isolated and identified from Morus plants (Tables 1 and 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7090062	The percentage of proliferating cells in five random fields of view per slide was determined under an inverted fluorescence microscope (Olympus, Tokyo, Japan) and expressed relative to that in the untreated control cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8303372	Dynamic light scattering (DLS) experiments and zeta potential measurements were carried out with a Zetasizer Nano S (Malvern Instruments, Malvern, UK) equipped with a 4 mW He–Ne laser (633 nm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11766332	It was identified in a copy number variation (CNV) screen associated with ASD .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "identified", "in", "a", "copy", "number", ...
PMC3765139	They are often characterized by elevated expression of stem cell surface markers, in particular CD133, and sets of differentially expressed stem cell-associated genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11525293	Cells were maintained in culture for no more than ten passages and underwent routine testing to ensure that they are mycoplasma-free.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "...
PMC9429973	Its management can be intensive, time-consuming, and costly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Its", "management", "can", "be", "intensive", ",", "time-consuming", ",", "and", "costly", ...
PMC11252033	All the conformations of the main cluster, including the best docked pose were found within the NADPH binding site, experiencing with the carboxylic group a key salt bridge with Lys324 and hydrogen bonding interactions with Asn48, Met325 and Gly160.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730305	Also, due to the amorphous nature of Ellagic acid, the composite material is amorphous and the peaks cannot be seen clearly (Fig. 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5963610	Tumor cells from 3LL-metastases post-treatments were obtained to determine the expression/activation of EGFR (A), p-EGFR (fosfo-EGFR, B), p-Stat3 (fosfo-Stat3, C), NGcGM3 ganglioside (D), uPAR (E) and α5β1 integrin (F) by flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11678448	By employing high-throughput RNA sequencing of human peripheral blood mononuclear cells stimulated with Mycobacterium tuberculosis antigens (Mtb-Ag) alongside control samples, researchers analyzed the immune pathways related to Mtb-Ag stimulation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4395774

Mice.

[ { "tags": [ "O", "O" ], "tokens": [ "Mice", "." ] } ]

PMC9841531

Certain drugs and druglike compounds have been reported to inhibit MCT1, such as benzbromarone (1) and quercetin (2), however, with rather low potency.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11607638

The SK peptides are known satiety factors to inhibit food intake in other insects.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "SK", "peptides", "are", "known", "satiety", "factors", "t...

PMC11411004

To investigate the effects of I-4 on monoclonal antibody-producing CHO cells in detail, we assessed changes in cell cycle phase distribution, cell viability, apoptosis rate, and cell proliferation following the action of I-4.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11487720

UV/cold shock or UV alone downregulates caspase 3, Bak, cortactin, and α-tubulin, and induces relocation of α-tubulin to the nucleus and the nuclear bubble.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11001582

n = 5 mice per genotype, one-way ANOVA, Bonferroni’s multiple comparison.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5", "mice", "per", "genotype", ",", "one-way", "...

PMC11703992

After identifying DDIT4 and ARHGAP15, we divided the CD4+ Memory T cells in GCA samples into DDIT4 ± and ARHGAP15 ± groups based on their expression.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11779960

Further, WGS and WES often result in low sequencing depth for the TCR region, leading to high noise unless validated by other methods.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11317131

Helper plasmids for mammalian expression called pCMV2 PhiC31 wt, pCMV2 HuOpt Bxb1 and pCMV2 HuOpt Pa01 encode wildtype PhiC31 (37), Bxb1 (22) and Pa01 (38) integrases, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7171147

b Western blot of FASN in ES2 cells expressing scrambled and DDR2 shRNA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Western", "blot", "of", "FASN", "in", "ES2", "cells", "...

PMC10698968

The 143B human osteosarcoma cell line was obtained by ATCC and was chosen as control in each experiment as an example of an extensively studied and characterised aggressive sarcoma cell line, unless differently specified.

[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11126803

E, in A498 cells, VM formation was significantly increased when ERβ was overexpressed, but this process could be effectively reversed by sh-ZEB1.

[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...

PMC11397654

The compounds were evaluated for their antiproliferative activity against two types of breast cancer cells, MCF-7 and MDA-MB-231, and a human normal epithelial cell line PNT1A.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11420784

Western blotting result showed a 0.87-fold increase of LC3-II in the isolated fraction from ΔpldA-infected 5637 cells compared to WT infected (Figure 3D), indicating PldA inhibits autophagosome formation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10530622

Hippuric acid is a protective metabolite since it increases the solubility of urinary oxalate .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hippuric", "acid", "is", "a", "protective", "metabolite", "since", ...

PMC9429973

Idiopathic acquired aplastic anemia (AA) is a bone marrow (BM) failure disease characterized by pancytopenia and a hypoplastic fatty marrow.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11348300

Furthermore, to facilitate comparative analysis, HS values were normalized to their maximum value in each specimen, corresponding to the HS value after the mice were killed.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Clinical characteristics are shown in Table 1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "characteristics", "are", "shown", "in", "Table", "1", "." ] } ]

PMC8623816

All R. solani strains were cultured on potato dextrose agar (PDA) medium at 28–30 °C and were stored on PDA slants at 4 °C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9436459

Most of the dehydroprenylsanggenonflavone type (Type F) MDAAs (ten compounds) were isolated from five Morus plants (M. alba, M. bombycis, M. cathayana, M. mongolica, and M. nigra), and simple or other dehydroprenylphenol type (Type H) MDAAs (five compounds) were distributed in five species including M. alba, M. macrour...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

However, its presence in MM patients without AL is extremely rare and there are few cases described in the literature.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "i...

PMC10237474

F-G) As in (D), but with (F) Protein 7 and (G) Protein 8 and their respective zoom-in analytical SEC traces. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

A. Bock, K. Poonsombudlert, M. Larson, J. Gile, R. Tawfiq, S. Maliske, M. Maurer, J. Cerhan, X. Andrade-gonzalez, A. Saliba, J. Paludo, D. Inwards, S. Ansell, T. Witzig, T. Habermann, B. Link, S. Ayyappan, G. Nowakowski, U. Farooq, Y. Wang Division of Hematology, Mayo Clinic, Rochester; Division of Hematology, Universi...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11604768

Upon GPCR activation by receptor agonists, these G protein complexes initiate distinct downstream signaling cascades.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Upon", "GPCR", "activation", "by", "receptor", "agonis...

PMC10667689

Further inquiries can be directed to the corresponding author.

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PMC11204465

This review attempts to give a comprehensive summary of progress on the chemical structural features, synthesis, and bioactivity of sterigmatocystins and aflatoxins reported from 1954 to April 2024.

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PMC10154881

Our rMV‐SLAMblind cancer therapy activated both ot these immune cell subsets, leading to the enhancement of therapeutic efficacy.

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PMC11348300

PpIX fluorescence absorption and emission spectra overlapped on oxy- and deoxyhemoglobin absorption spectra. (

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PMC10589262

PF was used at a concentration of 30 µM commonly used in previous in vitro and in vivo studies .

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PMC11727907

On the other hand, it is well known that the lower activity of PKM2 stimulates the PPP, promoting the synthesis of macromolecules and inhibiting the production of ROS .

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PMC5716223

Indeed, we demonstrated a significant enhancement of JNK phosphorylation after 15′–30′ min from NGF (20 ng/ml) supplementation in L6C5 myoblasts grown under serum starvation (p < 0.05) (Fig. 1d).

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PMC11551844

Peak 7 was isolated by preparative HPLC-DAD and was characterized by H-NMR spectroscopy (Fig. 4S†).

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PMC11397654

The supramolecular aggregate of 46 and 47 can be thus potentially used in targeted photodynamic therapy against cancer cells to inhibit unwanted cytotoxicity of the drug.

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PMC11682172

Mass spectrometry-based proteomics revealed significant alterations in the expression of 35 proteins by the breast cancer cell lines upon T cell contact.

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PMC11670407

We then investigated the mutual localization of GPX4 and OTULIN by immunofluorescence colocalization in U2OS cells under normal conditions and found that OTULIN and GPX4 were mainly localized in the cytoplasm; in the cytoplasm, the fluorescence of GPX4 and OTULIN overlapped (Fig. 4f).

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PMC10237474

Moreover, they share the highest similarity to human cells and thus produce proteins with human-like PTMs [2–4].

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PMC9429973

inducible KD/KO systems.

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PMC9429973

Data analysis was performed using the program IBM SPSS Statistics 26® Results: It was included 47 patients [42,6% male (n=20), 57,4% female (n=27)], median age at diagnosis of 70 years (61-81), median Eastern Cooperative Oncology Group performance status (ECOG PS) 1 (0-2) and median Charlson Comorbidity Index (CCI) 6 (...

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PMC11334037

A recent case study reported that a GISTs that produced big-IGF2 also caused severe hypoglycemia.

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PMC9429973

Towards this aim, we established CRISPR Cas9 dropout screens in PDX models of acute leukemias in vivo.

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PMC9429973

Overall response rate (ORR) in those with 1 prior therapy was 88% (n=14; 95% CI 61.7–98.4) in those with blastoid/pleomorphic disease (complete response [CR] in 50%, n=8) versus 81% (n=35; 95% CI 66.6–91.6) in those without blastoid/pleomorphic disease (CR in 47%, n=20).

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PMC11670407

g, h Tumor volume and tumor weight were measured and analyzed.

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PMC9429973

Certain mutations were acquired or lost during Richter transformation in some patients, indicating clonal evolution.

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PMC10994876

The cells were then detached using trypsin, washed with ice-cold PBS, centrifuged, and re-suspended in 100 μL of binding buffer.

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PMC11544122

BRET curves were fit by nonlinear regression (log(agonist) vs. response (three-parameters)) using GraphPad Prism.

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PMC11693599

In a previous study, we established a method for isolating CSCs from epithelial ovarian cancer cell lines (26).

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PMC10747160

As described in Section 2.6, the levels of p24 in each well were measured on a ClarioStar Plus microplate reader set to 450 nm (BMG Labtech, Ortenberg, Germany).

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PMC8389560

The PCR procedure consisted of 94 °C for 2 min followed by 35 cycles of 94 °C for 1 min, 60 °C for 30 s, and 72 °C for 30 s. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as an internal control for normalization and results were expressed as 2–∆(∆Ct).

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PMC11615743

Moreover, given the antinuclease, nontoxic, and low immunogenic nature of mirror‐image oligonucleotides, L‐DNA and L‐RNA probes have been extensively developed for therapeutic purposes.

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PMC9429973

SUMOylation is a post-translational protein modification pathway closely related to ubiquitylation.

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PMC10778532

Moreover, we found that sunitinib treatment inhibits ZHX2 expression and induces a reduced proliferation correlating with downregulation of P-ERK.

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PMC11543853

Cells infected by rhinovirus 2, echovirus 18, echovirus 30, and enterovirus 71 contained ruptured endosomes with openings of sufficient size to enable diffusion of the virus particles or genomes into the cytoplasm (Figs. 1a, b, 2g–j, Supplementary Fig. 1d, 2d, 3d, Supplementary Movie 1, Supplementary Table 1).

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PMC10854447

Also, those hybrids exhibit high intestinal absorbance and are non-substrate for P-gp.

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PMC11171319

The direct oncogenic role of HCMV following acute infection of primary epithelial cells (HMECs, OECs, and PECs) and human astrocytes is summarized in Table 2.

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PMC9429973

Further validation on larger and prospective clinical studies are needed C. Duane, C. Comerford, P. Murphy, P. Thornton, J. Sargent, S. Glavey, J. Quinn Department of Haematology, Beaumont Hospital Dublin; School of Medicine; Department of Pathology; Department of Haematology, Royal College of Surgeons in Ireland, Dubl...

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PMC11411131

Coexpression of SECIS binding protein 2 (SBP2) to enhance selenoprotein translation.

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PMC10891340

Mitochondria produce ROS, and mitochondrial damage can lead to the accumulation of ROS (Ma et al., 2020).

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PMC7642379

On chromosome 13, several genes associated with the cytoskeleton (BORA, MZT1, PIBF1, DACH1 and KLHL1) had a copy number gain in all progeny cell lines (Supplementary Table S3).

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PMC9429973

Five pts treated with TAG were bridged to a stem cell transplant (n=3 1L, n=2 R/R; Table 1).

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PMC9424261

C The ferroptosis-related metabolic axis from glucose to GSH.

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PMC11777207

GM-CSF BMDCs were collected at day 4, spun down, and counted, and 2.5 × 10 cells were spinfected for 2 hours at room temperature in 1 ml of collected viral supernatant containing polybrene at a concentration of 15 μg/ml (Sigma-Aldrich).

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PMC11394112

After intravenous injection of these cells into humanized NSG mice, we monitored the tumor growth and evaluated the organ-specific engraftment/progression period.

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PMC11633763

Therefore, early diagnosis and efficient treatment are crucial to improve patients' outcome and survival rate.

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PMC9429973

ASXL1 mutations are correlated with higher monocyte counts, increasing CD34 cells in peripheral blood (PB), larger spleen sizes, and higher MF grades.

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PMC9429973

The data pinpoint NF-ΚB activation as a biomarker for in vivo VEN-resistance and provide a specific biological rationale for ceasing VEN in deep response, as is currently being used in time-limited and explored in response-directed regimens.

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PMC11461833

ERVs are biomarkers of ageing, and affect various ageing-related diseases .

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PMC9429973

63% (157/249) of patients went through an ABVD regimen treatment; only 9 patients of this group were switched to an ABVD/ABV course of treatment after receiving CMR, in accordance to PET.

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PMC8164677

Each drug was added at four doses in three wells and incubated (37°C, 5% CO2 in air) for 72 h. Cisplatin and wedelolactone were prepared in desired concentrations (0.16–20 µM for cisplatin and 0.80–100 µM for test compound) followed by addition of 100 µL of each drug in triplicate wells.

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PMC9429973

Geriatric patients should be set at least age 65 or above as a cut-off level.

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PMC10713411

Furthermore, uni-Cox regression analysis among these 36 genes was conducted and the results demonstrated that 17 DEGs had significant correlations with OS (P < 0.05) of KIRC patients (Figure 2E), including 4 protective factors (HR <1) and 13 risk factors (HR >1), which were termed PRPCDGs.

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PMC11119602

Following 24 h incubation, the culture medium was removed and replaced with 100 µL of fresh culture medium containing cisplatin or the other drugs tested.

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PMC11310713

As shown in Fig. 3D and E, our results were similar to those of previous studies; the body weight increases typically in OVX rats.

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PMC11589157

The final prediction yielded 18,925 protein-coding genes (with 23,783 mRNAs), comparable to the gene counts in the Nleu_3.0 (18,991 genes, NCBI Nomascus leucogenys Annotation Release 102, 2015) and H. moloch genomes (19,302 genes).

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PMC11560255

After that, they were ground into a powder.

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PMC10772747

These findings provide a better understanding of the mechanisms of action of these compounds in inhibiting the growth of breast cancer cells and provide a strong basis for further research and development of cancer drugs using EBE as a potential agent to regulate the cell cycle in breast cancer.

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PMC11320834

To the best of our knowledge, this is the first attempt to prepare a liposome-based delivery system for topotecan and olaparib and to evaluate the effect of their combination in a 2D model of patient-derived ovarian cancer without BRCA1/2 mutation.

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PMC11578343

The inset illustrates the sinusoidal geometry of the contraction zones: the width of each zone is described by w contraction = wo + acos(ωt), where w o, a, and ω are the initial width, the strain amplitude, and deformation frequency, respectively.

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PMC11543885

Match Between Runs (MBR): Enable the Match Between Runs (MBR) function to align features across different runs.

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PMC11670407

Three replications were performed for the IP-OTULIN group.

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PMC11611077

Bands were visualized using a horseradish peroxidase (HRP)-linked anti-mouse IgG secondary antibody (Cell Signaling Technology, Danvers, MA) diluted at 1:5,000 and a chemiluminescent reagent (Amersham ECL Select Western Blotting Detection Reagent, Cytiva, Marlborough, MA).

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PMC11684269

Hence, SGLT2 inhibits CD4 T cell metabolism, including glutamine replenishment, glycolysis, and oxidative phosphorylation (OXPHOS), thereby ameliorating renal injury.

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PMC11622247

However, no discernible difference was observed between cells treated with the probe and those subjected to mock microporation (data not shown), indicating that the fluorescence intensity was insufficient to yield meaningful results given the low efficiency of delivery.

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PMC11745600

Female mice required 1 or 2 tablets.

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PMC11434983

DMSO was present at constant concentration (0.2%) in all experimental points.

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PMC11739504

Data were collected from three independent experiments.

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PMC11742290

LGR receptors including LGR5 are known for their involvement in the regulation of stem cells and tissue homeostasis .

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PMC11650848

Standard deviations were tightly clustered and the methylation differences between each genotype were statistically significant by ANOVA analysis (p < 0.001, Table 3).

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PMC11532793

The are estimated by trended empirical Bayes from the generalized linear model residual deviances (22,23).

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PMC9429973

Collected data was analyzed with ANOVA and CHI-squared for response in all patients.

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PMC9436459

MDAAs were at least found in 21 species of the family Moraceae, most of which were isolated and identified from Morus plants (Tables 1 and 2).

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PMC7090062

The percentage of proliferating cells in five random fields of view per slide was determined under an inverted fluorescence microscope (Olympus, Tokyo, Japan) and expressed relative to that in the untreated control cells.

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PMC8303372

Dynamic light scattering (DLS) experiments and zeta potential measurements were carried out with a Zetasizer Nano S (Malvern Instruments, Malvern, UK) equipped with a 4 mW He–Ne laser (633 nm).

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PMC11766332

It was identified in a copy number variation (CNV) screen associated with ASD .

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PMC3765139

They are often characterized by elevated expression of stem cell surface markers, in particular CD133, and sets of differentially expressed stem cell-associated genes.

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PMC11525293

Cells were maintained in culture for no more than ten passages and underwent routine testing to ensure that they are mycoplasma-free.

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PMC9429973

Its management can be intensive, time-consuming, and costly.

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PMC11252033

All the conformations of the main cluster, including the best docked pose were found within the NADPH binding site, experiencing with the carboxylic group a key salt bridge with Lys324 and hydrogen bonding interactions with Asn48, Met325 and Gly160.

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PMC11730305

Also, due to the amorphous nature of Ellagic acid, the composite material is amorphous and the peaks cannot be seen clearly (Fig. 3).

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PMC5963610

Tumor cells from 3LL-metastases post-treatments were obtained to determine the expression/activation of EGFR (A), p-EGFR (fosfo-EGFR, B), p-Stat3 (fosfo-Stat3, C), NGcGM3 ganglioside (D), uPAR (E) and α5β1 integrin (F) by flow cytometry.

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PMC11678448

By employing high-throughput RNA sequencing of human peripheral blood mononuclear cells stimulated with Mycobacterium tuberculosis antigens (Mtb-Ag) alongside control samples, researchers analyzed the immune pathways related to Mtb-Ag stimulation .

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