Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
 Community
1
PMCID
string
Sentences
string
ner
list
PMC11528603
Relative mRNA levels of proliferation–related genes in HL60 cells treated with SA-EA (4.1 μg/ml) in comparison with control cells treated with 0.05% DMSO.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11045125
To further investigate the RNA-seq finding that genes in the “Haddad_B_Lymphocyte_Progenitor” gene set are more highly expressed in the Myc-positive lymphomas (Fig 4B), immunoblot analysis was performed to examine protein expression of genes in this gene set that are upregulated in the RNA-seq results (S1 Table).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9917080
Increasing the time of incubation of astrocytes with SeNPs, So, or SeSo to 48 h also did not lead to significant depletion of the ER, relative to 24 h of incubation with the studied agents (Figure 8D,F).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10571053
Cells were trypsinized and incubated for 30 min in complete medium (phenol red-free Richter’s medium with 10% FCS and penicillin/streptomycin) with the desired fluorescent substrate (0.5 µg/mL rhodamine 123 to detect P-gp or 15 µM purpurin-18 to detect ABCG2) in the presence or absence of 25 µM concentrations of the de...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11471176
Moreover, if the concept of modulating ACE2 has a role on the management of COVID-19 is yet to be proven.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...
PMC7215832
Confocal microscopy experiments were performed to visualize the methylation of total DNA in A549 cells after 24–48 h treatment with 10 µM RX-3117.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7171147
It has been shown that ovarian cancer cells uptake exogenous fatty acids from the omentum to acquire tumorigenic and metastatic phenotype.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been...
PMC11490153
The characteristic solid band at 1092 cm is related to the reaction between calcium ion and carboxyl (CO-Ca-CO group structure), which increased C-O vibration.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11597291
Among the various conjugation processes, the most widely applied for the functionalization of GO nanomaterials has been the formation of amide linkages by EDC/NHS chemistry, the thiol linkages through dopamine, and the direct polymerization via linkages of initiators on the oxygen functional groups .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9436459
Next, the acetyl-protected dienophile S79 was obtained from the para-prenylated chalcone S77 in 33% yield by replacing MOM groups with acyl groups.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11786767
∗∗P < 0.01; ∗∗∗P < 0.001; one-way ANOVA.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗∗P", "<", "0.01", ";", "∗∗∗P", "<", "0.001", ";", "one-way", "ANOVA", "." ] } ]
PMC11185260
Both cell lines were transfected with either scL-SMARCB1 or scL-vec nanocomplexes and tested for SMARCB1 mRNA levels 48 and 120h later using RT-qPCR.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", ...
PMC10631132
Following hematopoietic differentiation cells were transferred to 6-well plates at 2 × 10 cells/cm and incubated in alpha-MEM (Bioscience Lonza, Basel, Switzerland) supplemented with 10% heat-inactivated fetal bovine serum (FBS) and 50 ng/mL human M-CSF for 3 days after which cells were incubated in alpha-MEM supplemen...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11695623
Wang showed that the expression of DEPDC1 was upregulated in LUAD tissues and exerted an oncogenic effect in LUAD, and that DEPDC1 inhibited autophagy through the RAS-ERK1/2 signaling pathway.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9545474
The ruthenium(II) centre in complex 4 adopts a pseudo‐octahedral structure, with Ru bound to a η‐p‐cymene ring, a S,S‐chelated dithiolate ligand and the phosphine as ligands to form an 18‐electron complex with “piano‐stool” geometry (Figure 4).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11566417
Previous work by our group identified stem cell secreted factors with the potential to decrease bacterial growth and viability and promote the regeneration of tissue.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11087301
They have an intense self-renewal capacity .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "have", "an", "intense", "self-renewal", "capacity", "." ] } ]
PMC7338939
Furthermore, by using mathematical models, on the basis of the tumor growth rate, we could estimate an optimal dosage of DAPT for supporting tumor regression in the xenograft mice and predict drug resistance at the proposed dose.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6114978
20 ng of genomic DNA was amplified utilizing GoTaq DNA polymerase (Promega, Madison, WI) and the following PCR cycling conditions: 95°C(95°C, 63°C, 72°C35 72°C.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680578
Therefore, there is a need for emerging synergistic therapies that utilize chemotherapeutic agents at lower concentrations along with other drugs to overcome the resistant effect of conventional cancer drugs along with providing effects to other therapeutic targets.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11545737
The disease has five main forms: bubonic, septicemic, pneumonic, meningeal and pharyngeal plague .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "disease", "has", "five", "main", "fo...
PMC8973725
The occurrence and development of cancer are closely related to the activation of oncogenes or inactivation of tumor suppressor genes by epigenetic modifications, including DNA methylation, chromosome remodeling, histone modification, and non-coding RNA regulation .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10759659
For the AMC cohort, only 167 patients identified to have HBV infection were included in this study .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "AMC", "cohort", ",", ...
PMC10587429
Embed the tissues in optimal cutting temperature compound and freeze at −80°C.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Embed", "the", "tissues", "in", "optimal", "cutting", "temperature", ...
PMC7171147
Mechanistically, we demonstrate that COL11A1 predominantly binds to DDR2 and activates Src-Akt-AMPK signaling to induce FAO (Fig. 6e) and blocking FAO attenuates COL11A1-induced cisplatin resistance by increasing mitochondrial apoptosis pathway.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017
Immunofluorescence staining of CRT was performed to observe CRT expression in K7M2 cells (Fig. 4J and K).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunofluorescence", "staining", ...
PMC11727000
Our data suggest that USP44 forms complexes with several known cancer genes implicated in several different cancer types.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "data", "suggest", "that", "USP4...
PMC11736898
Keratinocytes were inoculated into 24-well plates at 4 × 10 cells/well, and each donor strain (n = 3 normal, n = 4 keloid) was cultured in quadruplicate in keratinocyte growth medium plus vitamin D (0 nM, 10 nM, 50 nM or 100 nM alone, or 0 or 100 μM combined with ketoconazole or VID400), ketoconazole (0, 1, 5, 10, 20 o...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11531735
Ligand binding induces homodimerization or heterodimerization of HER proteins, activating downstream signaling for cell division, growth promotion, and apoptosis inhibition.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ligand"...
PMC10938336
After double staining, the cells were incubated in the dark for 30 min and analyzed in a flow cytometry analyzer (BD FACSCelesta).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9318744
This observation might be associated with the reduced ACE2 expression level in 43.20 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "observation", "might", "be", "associated", "with", "the", ...
PMC9429973
Median serum creatine level and eGFR were 349 μmol/L (range: 155-1718) and 12.9 mL/min (range: 2.5-36.3), respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10507284
The activation of known biological signatures in low (n = 131) and high (n = 132) TROAP expression subpopulations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973
TQB3602 was rapidly absorbed, resulting in a time to plasma peak concentration from 0.8 to 1.5 hours.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TQB3602", "was", "rapidly", "absorbed", ...
PMC11568601
However, due to different tumor type and context, efforts to improve cancer therapy by targeting IRE1 have primarily been limited to inhibiting its activity thus far .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11521786
PI sera and doxorubicin (Dx, 10 μM) were included as negative and positive controls, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PI", "sera", "and", "doxorubicin"...
PMC11155445
All the derivatives had more than 65% inhibition ability at 10M concentration, compounds (92ab, 92ac, and 93ab) were most potent and had inhibitory ability greater than 88% at 10 M concentration against AChE enzyme.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10823017
The BYL and ICA-1 combination treatment group showed an average wound healing rate of 24.5% (P<0.001).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "BYL", "and", "ICA-1", ...
PMC11388384
The topology of the tissue, defined by the geometry of physical boundaries between cells, determines the number of jumps a molecule needs to complete in order to reach a certain distance.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555
It was used a filtered buffer (5 mM Tris–HCl, 50 mM NaCl, pH 7.02) for the dilution of 0–50 μM of CT-DNA and 25 μM of the complexes 2–4.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706776
Indeed, the DiBAC4(3) fluorescence measurement is significantly higher in shRNA 511, shRNA 908 and shRNA 576 cells than in shRNA CT cells (Fig. 5A).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC11506827
Our study revealed the novel role of GEF as a sensitizer to TRAIL-induced apoptosis by upregulating DR4 and 5, which are essential for the extrinsic apoptosis pathway and TRAIL targeting .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365983
Equally, cerebellar anomalies reflect perturbation of the Hh signaling that is essential for cerebellar progenitor cell proliferation (midline cerebellar hypoplasia; Fig. 1B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973
The most common cause was hypoxia caused by smoking or COPD.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "common", "cause", "was", "hypoxia", "caused", "by", "smoking", "or", ...
PMC9429973
3-year PFS in patients who underwent autoHSCT was 48,6% (CI 35.8, 67,2), 3-year OS - 67,2% (CI 46.8, 78.9) to compare with patients who were the candidates for autoHSCT, but didn’t undergo autoHSCT: 3-year PFS 17,9% (CI 9.7, 31,2), 3-year OS – 33,7% (CI 16.7, 57.3) (p=0,036).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473750
RNF121 and c-MYC FISH assays were performed on 4 mm sections from three separate Tissue Microarray (TMA) blocks containing representative 1 mm tumour cores from head and neck squamous cell carcinomas.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698
Previous studies have reported downregulation of miR-140-5p , miR-148b-3p , miR-152-3p , miR-204-5p , and miR-211-5p in LC tissues.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11741906
Their involvement in cisplatin resistance was explored through regulation of MDR1 and PTEN gene expression .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Their", "involvement", "in", "cisplatin", "resistance", "was", ...
PMC9429973
Results: In ACTIVATE, 16 of the 40 pts (40%) treated with mitapivat and none of the 40 patients randomized to PBO achieved an Hb response as defined in the study protocol.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9954564
Several theories have been proposed to explain it, including the autoimmune, neural, biochemical, and genetic hypotheses.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "theories", "have"...
PMC11678841
Interestingly, GA (25 µM) was able to modulate the crosstalk between p38-SAPK and MAPK ERK1/2, which is important to control essential cellular processes of the infected cells, including innate immunity and inflammatory gene expression.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11499381
Background corrected fluorescence quantification values were derived for presentation by subtracting the mean value from vector control wells from each other condition within each experiment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9509578
Nanoconjugated gene silencing strategies have also been employed to target MDR-specific genes and inhibit CSC-mediated drug resistance.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nanoconjugated", "gene", "silencing", "strategies", ...
PMC11269792
Membranes were blocked with 5 % skim milk, mixed with primary antibodies GAPDH (60004-1-Ig, Proteintech), CDV3 (LS-C205853, LSBio), HK2 (22029-1-AP, Proteintech), PKM2 (15822-1-AP, Proteintech), followed by the secondary antibody (Sigma-Aldrich).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11539788
Recent studies have revealed that genomic factors combined with environmental factors such as smoking account for the tumorigenesis of BCa .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", ...
PMC6102174
7Structures of compounds 115–125 Structures of compounds 115–125 Cyperus rotundus Linneus (purple nutsedge), belonging to the family Cyperaceae, is a perennial herb indigenous to China and distributed in tropical and subtropical regions throughout the world.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10291556
Quantitative evaluation of phagocytosis of HeLa cells treated with the investigated compounds by human Thp-1/PMA macrophages (analyzed by flow cytometry).
[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantitat...
PMC11394730
Within the flavonoid subclass of flavonols, Quercetin (QUE; 3,5,7,30,40-pentahydroxyflavone) is the primary representative.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Within", "the", "flavonoid", "subclass", "of", ...
PMC7759933
The percentage of proliferating cells gradually declined with the time reaching 50% decrease after approximately 7 and 2 days of cultivation at an initial density of 3000 (Figure 2A) and 6000 (Figure 2B) cells/spheroid, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657744
P < 0.05; **, P < 0.01; ***, P < 0.001. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", ";", "*", ...
PMC11591038
Notably, under hypoxic conditions, salidroside pretreatment reduced the protein level of HIF-1α, suggesting that salidroside may attenuate a hypoxia-induced increase in BACE1, possibly through downregulating the HIF-1α protein level .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11335267
As positive controls, lysates from MIN6 pancreatic β cells, mouse embryonic day 10.5 forebrain (MEF), primary mouse embryonic mesenchyme (pMEM) cells and COS cells transfected with an Alx3 expression plasmid were used.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10713411
In addition, DNA damage is a common trigger of apoptosis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "DNA", "damage", "is", "a", "common", "trigger", "of", "a...
PMC11461874
We found that the Ub level was increased when TRAF7 was overexpressed (Fig. 3g), suggesting that TRAF7 mediates the ubiquitination of DBP.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11679326
Despite this, a common feature of mucin glycosylation is a disturbance in the processes of elongation and terminal capping of core O-glycan structures, which contributes to the formation of truncated glycan structures, which are often associated with malignant transformation processes and correlate with the severity an...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Eight deaths were recorded, none related to ponatinib treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eight", "deaths", "were", "recorded", ",", "none", "related", "to", "ponatinib", "treatment", ...
PMC11746948
Among these, only ZDHHC20 overexpression significantly enhanced GPX4 palmitoylation (Fig. 4a).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "these", ",", "only", "ZDHHC20", "overexpression", "significan...
PMC11638255
No caspase activity was detected in matched conditions containing neutrophils or neuroblastoma cells only, indicating specific neutrophil-mediated ADCC against neuroblastoma cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "caspas...
PMC10747160
Pellets containing Raji cells with captured pseudovirus were then resuspended in 90 μL of DMEM supplemented with 10% Fetal Bovine Serum (heretofore referred to as Final Infectivity Media).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10729469
The mixture was transferred into the Primary Cell 4D-Nucleofector™ X Kit S (cat.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mixture", "was", "transferred", "into", "the", "Prim...
PMC9429973
G. Tsykunova, P. A. Holme, H. Thi Thyuet Tran, T. H. A. Tvedt, L. Munthe, M. Michel, H. Frederiksen, J. Bussel, D. Kuter, W. Ghanima Departments of Medicine, Hematology-Oncology, and Research, Østfold Hospital Trust, Kalnes; Division of Hematology, Department of Medicine, Haukeland University Hospital, Bergen; Institut...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9927933
Cells were lysed in 6 M guanidinium denaturing solution and sonicated.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "lysed", "in", "6", "M", "guanidinium", "denaturing", "solution", "an...
PMC9429973
Overall survival of mice transplanted with SMARCA4 overexpressing MV4-11 cells was significantly worse than in the control group, whereas mice transplanted with SMARCA4 knockdown MV4-11 cells lived significantly longer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC10362265
Panel shows the computed complex structure of human IL18-IL18BP by AF2 that was colored according to residue confidence score (red: pIDDT < 50, yellow: pIDDT < 60, green: pIDDT < 70, cyan: pIDDT < 80, blue: pIDDT < 90).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11049294
The detected fluorescence is determined by the amount of Fl-Gb3 accumulation and AGAL activity (Figure 1D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "detected", "fluorescence", "is", ...
PMC11243198
These six compounds were evaluated to determine their potency in C3H10T1/2 cells with the flu AP readout.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "six", "compounds", "were", "evaluated", ...
PMC5673955
However anti‐telomerase activity of RrA may affect normal activated lymphocytes since telomerase is active in these cells 21.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", "anti‐telomerase", "activity", "of...
PMC10587429
Combine the remaining samples into a “pooled” sample and aliquot 50 μL of the “pooled” sample into separate 12 x 75 mm tubes for single color and unstained compensation controls as well as fluorescence minus one (FMO) controls ( Table 2 ).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7305184
Electroporation pulses alone do not cause cells to develop adaptive resistance to IRE.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Electroporation", "pulses", "alone", "do", "not", "cause", "cells", "to", ...
PMC11507371
Based on the obtained results, it appears that the intracellular distribution of Keap1 remains relatively unaffected by stimulation with plasma (Figure 5B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8973725
Combined with data from the TCGA database, the results of the present study demonstrated that ZNF677 acts as a tumor suppressor gene with significantly higher methylation in ccRCC tumor tissues than that in normal tissues.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Aims: We aim to get insights into one-carbon metabolism regulation in CLL, identify new therapeutic targets and find new treatment options for CLL patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11544122
Similarly, agonist-stimulated endocytosis of β2AR, AT1AR or another prototypical GPCR, vasopressin (V2R), which also undergoes β-arrestin-dependent endocytosis, was not impacted in the SNX9 HEK293 KO cell line transfected with siRNA against SNX18 (SNX9-KO/18si) (Fig. 4b).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
On the other hand, it is female donors who present themselves regularly for a blood donation as opposed to the male sex: (n=649 M, n=102 F): p=0.009 (S).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4112127
A second construct expressing the full-length BMP3 cDNA was prepared in our laboratory by cloning into the expression plasmid pcDNA3.1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "second", "construct", ...
PMC10604092
Thus, we can conclude that the muscle atrophy observed in the rats in our cancer cachexia model was caused by both accelerated muscle degradation and decreased muscle synthesis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11129910
The RAB (Ras-related in the brain) proteins belonging to the RAS superfamily of RAS GTPases regulate the vesicular trafficking machinery.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RAB",...
PMC11635519
After 4 h of incubation at 37 °C, cAMP d2 reagent and cAMP Eu-Cryptate antibodies were added to each well.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "4",...
PMC11635087
In addition, no morphological abnormalities or decreases in chloroplast fluorescence were observed after a long-term storage at 4℃ (Fig. 2C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8864075
Cells in the upper surface of the membrane were completely removed with cotton swabs, and cells migrated to the lower membrane surface were fixed with 4% paraformaldehyde for 5 min.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11583010
ETx-22 represents a valuable therapy for the treatment of patients with nectin-4–expressing tumors, including those that are resistant to EV treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ETx-22", "re...
PMC9429973
No patient developed anti-drug antibodies during the study period.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "patient", "developed", "anti-drug", "antibodies", "during", "the", "study", "period", "." ] } ]
PMC10452486
Based on these preliminary observations, we have postulated an evolutionary tree for HLA-I and HLA-II with B2m- free HC as the progenitor, as shown in Figure 7.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727638
The 2D cultured cells were used as a control.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "2D", "cultured", "cells", "were", "used", "as", "a", "control", "." ] } ]
PMC10758402
The data underwent analysis using FlowJo v10.8 software.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "underwent", "analysis", "using", "FlowJo", "v10.8", "software", "." ] } ]
PMC11525028
Volcano plot showing the ac4C peak of NAT10-KO compared to control cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Volcano", "plot", "showing", "the", "ac4C", "peak", "of", "NAT10-KO", "compared"...
PMC11291490
Consequently, for effective vaccine outcomes, it is imperative to prime and expand MHC II-restricted CD4 T cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "for", "effec...
PMC11759543
The targeted epigenetic therapy of HDAC inhibition influences gene expression and ultimately controls tumor growth and proliferation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "targeted", "epigenetic", "therapy", "of", ...
PMC9429973
Number of cycles of consolidation given to date were 1, 1, 1, 2, and 5 cycles, respectively, and none of these pts have received allo-SCT yet.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11521786
In graphic representations, significant differences were highlighted with asterisks: p < 0.05, p < 0.01, p < 0.001, and p < 0.0001.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...