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OTAR3088
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BioData-CellLine_annotated

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PMC11742670
Afterwards, the descriptors or features for each drug are developed using RDKIT which is an open-source toolkit for cheminformatics and ML.
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PMC7802142
Scale bar, 50 μm ReN-NV administration promotes cell proliferation in hair follicles (HFs).
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PMC11720107
This method detects the metabolic activity of cells and can indirectly suggest cell numbers, although this requires further confirmation.
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PMC10114490
We selected the fourth strategy (diHLC-T) since it can deliver HLC from cultured cells even after at least 110 population doublings (reproducibility).
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PMC7823217
Figure C is reproduced from with the permission of PNAS.
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PMC9895440
Intracellular antibodies were then stained in 1x Permeabilization buffer (eBioscience) for 30 min at 4 °C.
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PMC11665584
We hypothesize that expression of PITX1 in adult oral and corneal epithelium and its absence in the epidermis suggests that it may play a key role in tissue-specific keratinocyte identity and the ability of the tissue to heal more rapidly following injury compared with the skin.
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PMC11190062
Cells were seeded at a concentration of 250,000 cells/mL and treated with LPS or CpG. The following day, additional media containing TLR agonists was added to ensure exponential growth of the cells.
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PMC11772449
The above research results suggest that inhibiting the activation of p38α may activate autophagy, and our results suggest that inhibiting p38γ can down-regulate the level of autophagy.
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PMC7504302
Recently, Sementino et al. have generated animal models to study the cooperation between PTEN and TP53 inactivation in MPM pathogenesis.
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PMC8345486
Differences between treatment groups and controls were assessed by analysis of variance (ANOVA) or the Kruskal–Wallis test, followed by two-tailed Student’s t-test or nonparametric tests, respectively with the Bonferroni correction for post-hoc evaluation, unless mentioned otherwise.
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PMC11285179
Thus, we measured the retinoic acid content in pericytes using LC–MS technology.
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PMC11597167
The change in gene expression levels of a total of 14 genes (APP, PSEN1, ABCA7, APOE, CLU, PICALM, BIN1, CD2AP, CR1, CD33, SORL1, MMP9, TNF, and CCL5) is presented in Table 5, which were normalized to β-actin .
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PMC10671321
Control and iPSC-derived skeletal muscle cells all show the presence of AChR clusters after agrin stimulation.
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PMC11568601
These results were also further validated in the ER stress inhibitor, 4-PBA, treatment group .
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PMC11679892
While this study demonstrates significant fold changes in gene expression for several apoptosis-related genes in SHSY5Y cells using RT-PCR, one of the limitations is the absence of protein-level validation through Western blot analysis.
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PMC5025404
The plasmids were modified by transferring DNA fragments encoding the HC and LC genes from the donor vectors to the plasmids.
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PMC10529414
Immunoprecipitation was performed with an anti-RUNX2 antibody (Cell Signaling Technology-USA.,
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PMC11670407
The values are expressed as means ± S.D.s. *
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PMC11535726
Faces of Fungi and Fungal name numbers were obtained following the guidelines in Jayasiri et al. (2015), Wang et al. (2023) and Fungal names (2024).
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PMC7724160
In addition to examining quality attributes, we also measured the impact of cellular passaging on metabolic state.
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PMC11766174
Slides were air dried for 30 min at RT and immersed in 50% ethanol (EtOH) for 5 min, followed by immersions in 70% EtOH for 5 min and 100% EtOH for 5 min.
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PMC11684821
Of these substitutions, only R9H, present in MR1*04, is close to the known MR1 antigen binding site.
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PMC9429973
J. Fishman, S. Kuranz, M. Yeh, K. Brzozowski, H. Chen Apellis Pharmaceuticals, Waltham; TriNetX, LLC, Cambridge, United States of America Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and potentially life-threatening disease involving complement-mediated hemolysis and thrombosis.
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PMC11673128
The number of pHrodo events within macrophages was counted to obtain the phagocytic index, determined as the number of ingested cells per 100 macrophages (counting at least 200 macrophages per condition) .
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PMC5311252
Interestingly, the distribution of the number of algorithms predicting the same target mRNA was bimodal with a peak in targets predicted by five algorithms suggesting a threshold for higher algorithm consistency (Supplementary Figure 1b).
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PMC9777812
A total of 10 µL of CCK-8 solution was added to 100 µL cell suspension and incubated for 2 h, followed by absorbance assessment at 450 nm (n = 5).
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PMC9429973
Methods: We included 663.184 adult patients from primary care in the greater Copenhagen Area who had a complete blood cell count (CBC) performed at any time between 2000-2016.
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PMC11783017
.
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PMC9727330
Quantification of the mRNA expression level of the P53 gene indicated by fold change in treated Caco-2 cells compared with untreated cells (N.T.) and DMSO-treated cells. (
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PMC11740573
Cells were grown in 12-wells flat-bottom tissue culture plates (TPP, Switzerland) at 37 °C with 5% CO2 and passaged every 3–5 days using trypsin.
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PMC11300639
i, j 786-O cells were treated with indicated plasmids or siRNAs for 48 h. Cells were harvested for immunoprecipitation and western blotting assay.
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PMC9429973
One strategy to improve the outcomes of r/r AML is to perform HSCT after aplasia-inducing chemotherapy.
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PMC11468365
So, a graph neural network is applied rather than a standard convolution network.
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PMC9429973
Summary/Conclusion: When planning the first and subsequent, repeated, AutoHSCT in MM patients, it is advisable to prepare an autograft with a greater than suboptimal cellularity due to a possible decrease in the number of CFU during long-term cryostorage of the cell suspension.
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PMC9429973
Among these, high levels of LINC01268, MALAT1 or GAS5 correlated with several detrimental clinical features of MF, such as high counts of leukocytes and CD34+ cells, a severe grade of bone marrow fibrosis and the presence of splenomegaly.
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PMC11746948
Indicators such as huddled posture, immobility, ruffled fur, failure to eat, hypothermia (colonic temperature of <34 °C), or weight loss (>20%) may be useful objective criteria for early euthanasia.
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PMC9429973
Most NHL patients initially respond to chemotherapy yielding complete response rates of 40–50%.
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PMC11789597
p‐values were calculated with unpaired two‐sided Student t‐test or Mann–Whitney U test.
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PMC11532793
Second, we replace edgeR v3 with edgeR v4.
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PMC11750161
In the M410T mutant, the Rmax level was the lowest among all activating mutants.
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PMC10919056
Furthermore, to investigate the effects of GJA5 and GJB1 interference on the cytological behavior of ccRCC cells, at least three independent cell experiments were conducted (Figures 10C, D).
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PMC11285179
After digestion, the solution was filtered through a 40 μm filter and centrifuged.
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PMC11679892
In our study, the RT-PCR results revealed significant increases in BAX, caspase-3, caspase-8, and caspase-9 gene expression.
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PMC9429973
A. Zaninoni, B. Fattizzo, J. Giannotta, E. Fermo, P. Bianchi, N. Cecchi, W. Barcellini Hematology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy Background: Autoimmune hemolytic anemia (AIHA) is highly heterogeneous and involves several pathogenic mechanisms including autoantibody production, ...
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PMC8633974
Both cells show robust luminescence upon addition of Luciferase substrate to cell lysate confirming expression of luciferase delivered by LNP. (
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PMC11361748
K8/K18, a prominent keratin pair in simple epithelia, binds to and stimulates the phosphorylation-dependent activation of Akt1, promoting hepatocyte survival after liver injury .
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PMC11216402
Among the genes upregulated in Mes-like cell lines are the fibrotic gene FGF5 and many collagen genes downstream from the TGFB/SMAD pathway (Verrecchia et al. 2001; Shin et al. 2019; Xie et al. 2020).
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PMC11377827
n = 3 biological replicates, ****P < 0.0001 control vs. USP43 KO, two-way ANOVA.
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PMC11604015
Under these conditions, subsequent HSCT does not require an additional myeloablative conditioning regimen or GvHD prophylaxis, which can prolong the persistence of CAR-T cells and reduce chemotherapy-related toxicities.
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PMC10976516
Next-generation cell carriers have the potential to develop into sophisticated, mobile biological factories that can launch a coordinated, multifaceted attack on tumors as our knowledge of cell trafficking, tumor biology, and virology advances.
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PMC11394730
After subcutaneously injecting 5 × 10 SMMC-7721 cells into BALB/c-nu nude mice, the ameliorative impact of emodin was analyzed.
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PMC11787651
C, overlaid TIC for 50 consecutive injections.
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PMC9844987
Average contribution (SHAP values) of CpG content and each of the 124 TFs identified as important for predicting promoter variability.
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PMC9429973
Aims: To characterize the outcomes for pts diagnosed with EBV PTLD following SOT who fail initial rituximab plus CT in a multi- national real-world setting.
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PMC9786247
Thus, the milk of infected animals represents a risk factor for the spread of C. burnetii infection within a flock, apparently independently of C. burnetii isolate genotype.
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PMC9429973
Image: Summary/Conclusion: Taken together, our investigation provides pre-clinical evidence for the utility of FB23-2 in CLL, especially combinatory benefit with ibrutinib.
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PMC9429973
The 8-item Patient Health Questionnaire depression scale (PHQ-8; range, 0–24) and the 7-item Generalized Anxiety Disorder scale (GAD-7; range, 0–21) were used to screen patients for depression and anxiety.
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PMC11754784
We first built a kinetic model to describe the molecular diffusion by solving the second-order partial differential equation of Fick’s second law (Supplemenatry Note 1).
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PMC11319300
The experimental data and the results from the simulations strongly suggest that the human MYEOV-3′-putative enhancer interacts with the proto-oncogene CCND1 and LTO1.
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PMC11585254
β-arrestins are considered to be master regulators of GPCR signaling by mediating desensitization, internalization, and signaling (Wess et al., 2023).
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PMC11705547
Cisplatin enters tumor cells via CTR1 or passive diffusion.
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PMC11442172
These findings could have important implications when studying various cancer drugs that target energy metabolism.
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PMC11448304
Finally, the supernatant was collected and the protein concentration was determined with BCA kit.
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PMC11768281
Subunit vaccines use “vehicles” or vectors to deliver antigens to subjects.
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PMC10165258
This viability calculation does not rely on any user input and has proven high consistency with the images of this study.
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PMC11640476
In this manuscript, we applied and validated our previously described comprehensive optimization approach to optimize the resazurin-based viability assay on the A549 cell line in both 2D and 3D (fibrin gel) in vitro models.
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PMC9429973
Testing was performed in 37 MPN patients after one dose, 61 after 2 doses and 30 after 3 doses to date.
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PMC9429973
After 12 months, ORR was observed in 42.8% (n=6), with CR in 35.7% and PR in 7.1%.
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PMC11665555
Next, we developed an acquired resistance model with the 5637 cell line.
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PMC9587298
Nevertheless, no study has been performed to evaluate its antiglycation potential and, to the best of our knowledge, this study is the first to address this question.
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PMC6642070
Increased lactate production was in accordance with increased glucose consumption as evidenced by direct measurement of residue glucose in the medium (Supplemental Fig. 2a) and by flow cytometric analysis of the fluorescent deoxyglucose analog 2-NBDG (Supplemental Fig. 2b).Fig.
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PMC11794588
It can also be used to relieve constipation, bloating, and stomach pain.
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PMC5600151
These results reflect positively on the great expectations for the potential of dendrimers to be used in nanotechnology-based cancer therapy.
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PMC7154001
On the other hand, four metabolites (Flu-1, OH-flu, M1, and M3) were detected after incubation of the compound with liver microsomes from rat, dog, and pig.32 Moreover, similar metabolite (OH-flu) was detected in rat and pig, but this metabolite was detected as 3 and 2 isoforms in rat and pig, respectively.32 For the s...
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PMC11477621
H NMR (600 MHz, CDCl3) δ 7.50 (dd, J = 8.6, 5.4 Hz, 1H), 7.03 (d, J = 3.1 Hz, 1H), 6.98 (dd, J = 10.0, 2.3 Hz, 1H), 6.85 (td, J = 9.1, 2.2 Hz, 1H), 6.44 (d, J = 3.1 Hz, 1H), 4.00 (t, J = 7.1 Hz, 2H), 2.04 (t, J = 7.4 Hz, 2H), 1.76 (p, J = 7.0 Hz, 2H), 1.55 (p, J = 7.1 Hz, 2H), 1.30–1.20 (overlap, 4H).
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PMC11638255
Although the increase in CD11b cells by immunohistochemistry was explicitly defined as neutrophils as per single-cell transcriptomics and flow cytometry, future profiling efforts should seek to elucidate their diversity and plasticity within the neuroblastoma tumor microenvironment as per other solid cancers.
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PMC11127909
This study was approved by the Ethics Committee of The Eighth Affiliated Hospital, Sun Yat-sen University.
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PMC9429973
Methods: We investigated 45 patients with AML/MDS who were treated with Decitabine.
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PMC10944868
TPSA is a measure of the polar surface area of a compound, which is important for its interaction with biological targets and its ability to cross biological membranes.
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PMC11607321
This leaves a gap in the utilization of these non-linear approaches to augment datasets and perform statistical analysis to improve the characterization of cancer mechanisms, biomarkers and drug targets.
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PMC10958426
On the other hand, analyses of signaling enriched in DEGCNV showed that structural constituent of ribosome, cell adhesion molecule binding and cadherin binding in several patients (Fig. 4F), indicating ribosome and cell adhesion molecule binding genes played important roles in shaping tumor subclones or tumor heterogen...
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PMC3931643
Shown to the right of the graphs is a western blot showing induction of 4EBP1 expression with 1 µg/ml Doxycycline.
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PMC9429973
Aims: To decipher the role of the lysosome-associated gene LAPTM4B in AML will be the main objective of this study.
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PMC11413393
RCC243 cells were treated for 3 days with 5 µM MS023 and then exposed to the interstrand cross linking agent mitomycin C (MMC).
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PMC11583010
This was achieved by visual inspection using the images gridded on the ImageQuant software.
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PMC9429973
All patients with UCD were treated with surgery.
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PMC10823017
In 786-0 cells, the PKC-ι associated c-Myc level is also reduced drastically (P<0.001; Figure 7A ) by the combination treatment.
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PMC10976516
Furthermore, genetic engineering of OVs could be further exploited to enhance the “collaboration” between viruses and carrier cells, for example, to boost carrier cell migration into the tumor bed or to achieve prolonged release of OVs from carriers without cytopathic effects.
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PMC11723947
d Representative dot-plots showing the percentage of HLA-B7 WT and HP1γ KO human Tconv producing IFN-γ and GM-CSF.
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PMC9429973
Patients with cyclin D1-positive DLBCL patients had more Ki-67 proliferation, elevated serum lactate dehydrogenase and more advanced stage (P<.05).
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PMC8358006
The ESCC cells were cultured in RPMI-1640 medium with 10% FBS.
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PMC9964654
C. glabrata overnight-grown fungal cultures (carried out in YPD broth at 30 °C and 250 rev.
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PMC10729469
Non-activated microglia exhibit ramified morphology and can clear Aβ deposits through phagocytosis .
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PMC11621493
Loss-of-function studies indicate that PLA2G4D affects metabolic and signaling pathways in keratinocytes, which is associated with complex lipidomic and transcriptomic alterations.
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PMC11286266
Immunoblot of whole-cell lysates from the indicated genotyped probed with antibodies against FURIN and the loading control actin.
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PMC9581083
The potential efficacy of the herbs of Taiwan Chingguan Yihau (NRICM101) used as adjunctive therapies in COVID-19 infection.
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PMC9739791
The Pt(IV) prodrug 17 was found to be stable in the dark, both in the absence and in the presence of sodium ascorbate.
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PMC9429973
The reason being the fact that karyotype analysis is one of the indispensable tools for identification of additional chromosomal abnormalities of prognostic significance.
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PMC11461874
D-box-dependent transcription is activated by D-site binding protein, DBP, and repressed by E4BP4, also known as NFIL3.
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