OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11464982	NA: not analysed.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "NA", ":", "not", "analysed", "." ] } ]
PMC10547921	Chemical structures of tubulysin analogs 28–34; (B) Binding mode of compound 30 in complex with tubulin (PDB code 6Y4N).Figure 6 Design and SAR analysis of tubulysin analogs. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	In line with previous reports in keratinocytes , Western analysis of STAT1 phosphorylation was performed following 3 h of EGFR inhibition (Fig. S6) revealing an increase in STAT1 phosphorylation to a similar level found with ALOX15B silencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591794	The expression of selected genes and housekeeping genes were analyzed in a Q-PCR device (Bio-Rad CFX96).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "selected", ...
PMC10858941	Viability staining shows in green alive cells and in red dead cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Viability", "staining", "shows", "in", "green", "alive", "cells", "and", "in", ...
PMC7171147	Secondly, malonyl COA might be compartmentalized to prevent inhibition of CPT1A so that FAO is uninterrupted or rapidly utilized to meet cancer cells’ high demand for energy and/or biomolecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301095	CSF adenosine deaminase was 7 U/L. The CSF characteristics suggested bacterial meningitis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CSF", "adenosine", "deaminase", "was", "7", "U/L.", "The", "CSF", "characteristi...
PMC9429973	Univariate analysis of each MIPSS70 variable on OS was carried out, with statistically significant differences being confirmed for all variables except fibrosis grade and HMR mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747467	A power value of β = 10 was chosen to construct a scale-free coexpression network ( Supplementary Figure S2B ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "power", "value", ...
PMC11367939	ATG9A is the only integral membrane protein among core autophagy-related (ATG) proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ATG9A", "is", "the", "only", "integral", "membrane", "protein", ...
PMC9878278	Forward and reverse primer sequences used for TGF-β family members, STAT1 and IRF7 are shown in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Forward", "and", "reverse", "prim...
PMC10523483	NSCLC cells with higher ROS levels are more vulnerable to ROS-inducing agents (11), and the higher GSH levels are associated with chemoresistance (12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7887261	P-value < 0.05, **P-value < 0.01, n.s not significant (P-value > 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P-value", "<", "0.05", ",", "*", ...
PMC11391695	Every experimental procedure was conducted in strict adherence to the pertinent regulations and institutional protocols established by Nantong University.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Every", "experimental", "procedure", ...
PMC11365427	Similarly, phenylalanine-deprivation diets influenced mouse body weight, which remained stable and within acceptable limits (Fig. 4G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", ...
PMC7090062	In accordance with the results of western blot analysis described previously, we found that the miR-30a mimic suppressed the formation of IM-mediated LC3 puncta and autophagic vacuoles compared with those detected in the IM, whereas the miR-30a inhibitor mediated the opposite effects (Fig. 4b, c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10560648	Jurkat cell growth was inhibited by 48.9% after 72 hours of treatment with 250µg/mL Cassiopea andromeda venom.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Jurkat", "cell", "growth", "was", ...
PMC11711127	Replicative senescence is a process that occurs as a result of many rounds of replication leading to shortened telomeric length and subsequent senescent state to prevent its potential progression toward malignancy (76).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635519	Our method could help identify novel GPCR-activating peptides for structure–function or drug discovery studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "method", "could", "help", "identify", "novel", ...
PMC11700165	In resting cells, SYK retains a “closed” conformation, where the tandem SH2 domains fold together with the kinase domain adapting a so-called “linker-kinase sandwich”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11759751	In this study, we investigated whether the anti-B-NHL ability of CD19 CAR T cells could be enhanced by the pretreatment of chidamide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC9429973	Regarding toxicity, cumulative incidence of treatment-related mortality (TRM) (including transplant-TRM) at 5 years was 17% (95% CI 14-20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10671321	As shown previously in rodents, pathogenic variants in the CTD can lead to the near absence of AChE at the synapse or just to a reduction of AChE activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8740518	Statistical analysis was performed using R package “limma” to screen for statistically differentially expressed genes (P-value <0.05) and to calculate fold changes of selected genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10858941	Cell lysates were separated by SDS-polyacrylamide gel electrophoresis and transferred to a polyvinylidene difluoride (PVDF) membrane (Merck Millipore, Massachusetts, USA; IPVH00010).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11779605	ES-2/GFP-luc (hereafter called ES-2) ovarian cancer cell line (17) (gifted by Dr. Branimir I. Sikic, Standford University, Stanford, CA, USA) was authenticated by the short tandem repeat method and proven to be negative for mycoplasma, Hantaan, and lymphocytic choriomeningitis viruses prior to use.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	Genes were considered differentially expressed if the fold change value was ≥1.5 and the P value was ≤0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genes", "were", "considered", "differentiall...
PMC10994876	These genes are known to be involved in important cellular processes such as apoptosis and cell division, and they have previously been used as indicators of YAP activity at the transcriptional level (Mugahid et al. 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9910796	The absence of unwanted mutations in the resulting plasmid pRepgus72I was verified by conventional Sanger sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "absence", "of", "unwanted", "mutations", "in", ...
PMC10958426	Qubit and Qsep100 were used to measure DNA concentration and fragment length of each library, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Qubit", "and", "Qsep100", "were", "used", "...
PMC11806182	Notably, testosterone was correlated with the up-regulated genes, while two phytoestrogens, enterolactone and coumestrol, were also associated with the up-regulated gene set.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11451940	The data were collected using a BD FACSVerse flow cytometer (Becton Dickinson, USA) in three separate experiments, each performed in duplicate, with at least 5 × 10 events recorded for each sample.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11515150	Expansion of NK cells with IL-2 combined with IL-15 or without IL-15 for 14 days (n = 3, left panel), and cell viability of NK cells with different concentrations of IL-15 (n = 3, right panel). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8978939	All procedures were approved by the Animal Care and Use Committee of the Hospital de Niños Dr. Ricardo Gutiérrez.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "procedures", "were", "appr...
PMC8806312	The Database for Annotation, Visualization, and Integrated Discovery (DAVID) 6.8 (https://david.ncifcrf.gov) was used for gene function analysis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11726848	It is worth noting that we observe an increase in cell size after LDR irradiation by 1.5–2 times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "worth", "noting", "that", ...
PMC11594588	In physiological conditions, cellular DNA and the nucleobases are constantly exposed to ROS, which causes their oxidative damage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "physiological", "condi...
PMC11549062	Endosome and lysosome trajectories of cos7 cells with the treatments of Rab5 knockdown, PDGFR‐β knockdown, or both knockdowns. (	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Endosome", "an...
PMC10734950	Afterward, they were resuspended in a pre-warmed mixture of carboxy-H2DCFDA and 1 x PBS, making a final concentration of 10 μM dye.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Based on IPSS, 78% of patients were in the low and intermediate 1 risk groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "IPSS", ",", "78", "%", ...
PMC11790599	Images were captured on a microscope equipped with a Leica DFC310 FX digital color camera at a 20 × objective.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "were", "captured",...
PMC10955424	Crizotinib at 2 μM was combined in the appropriate samples as indicated (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Crizotinib", "at", "2", "μM", "was", "combined", "in", ...
PMC11699465	Then TMEM199 interacting proteins (TIPs) were pulled down with an anti-TMEM199 antibody and identified using mass spectrometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", "TMEM199", "interacting", ...
PMC11525028	These results demonstrated that NAT10 regulated ATF4 through ac4C modification and overexpression of ATF4 rescued proliferation and metastasis, which were impaired by NAT10-KO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11623887	They found that as cells differentiated, GATA-1 expression increased, and leading to the accumulation of nuclear GATA-1 protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "found", "that", ...
PMC11087055	See also Video 1 and Figure 1—source data 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "See", "also", "Video", "1", "and", "Figure", "1—source", "data", "1", "." ] } ]
PMC6803987	The membrane was blocked in 5% skim milk for 2 h, and incubated overnight at 4 °C with rabbit anti-HBx (1:500) and rabbit anti-GAPDH (1:5000).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10887351	The main mechanism responsible for the β3-AR-induced cardio-protective effect was shown to be the NOS activation and production.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "main", "mechanism", "responsible", ...
PMC9429973	Image: Summary/Conclusion: These results clarified the comprehensive immune structures including novel tumor-specific markers in TFH lymphoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", ...
PMC10529414	.	[ { "tags": [ "O" ], "tokens": [ "." ] } ]
PMC11063646	94517.	[ { "tags": [ "O", "O" ], "tokens": [ "94517", "." ] } ]
PMC9596868	Following the incubation, 2 μl PI (BD Biosciences, Cat no. 556547, 51-66211E) was added to the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9927933	However, the underlying mechanism by which UBE2C suppresses autophagy in lung cancer cells, and whether UBE2C plays an in vivo oncogenic role during lung tumorigenesis, are unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11672142	Table 1 tabulates the calculated averages of GI50 and TGI (the Supporting Information includes the full testing results including the LC50 values in Table S2 and the dose–response curves of the nine different panels of cell lines in Figure S18).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11366496	Collectively, RNF122 enhances tumor development through JAK2/STAT3/c‐Myc signaling axis activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collectively", ",", "RNF122", "enhances", "tumor", "development", "through", "JAK2/STAT3/c‐Myc", ...
PMC9429973	We performed WES of DNA samples from five patients and their parents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "performed", "WES", "of", "DNA", "samples", "from", "five", "patients", ...
PMC11240448	We determined causal connections within the core networks and developed interpretable mechanistic models that elucidated the drivers of cell phenotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "determined", "causal",...
PMC11786704	H&E staining of wound sections on day 14, showing tissue regeneration. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H&E", "staining", "of", "wound", "sections", "on", "day", "14", ",", ...
PMC11768927	Other oncolytic viruses, like vaccinia virus, can be utilized in combination with VSV to improve the efficacy of virotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "oncolytic", ...
PMC10604092	This medium was supplemented with 10% fetal bovine serum, 2 mmol/L L-glutamine, 100 U/mL penicillin, and 100 µg/mL streptomycin and the cells were cultured in 5% carbon dioxide at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9784246	Boswellia serrata and Viscum album extracts, for example, have passed laboratory investigations and are now undergoing clinical trials .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Boswellia", "serrata", "and"...
PMC11770130	The serum samples were collected by centrifuging the whole blood cells of mice for 10 min at 4000 rpm and stored in a deep freezer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11617590	In early apoptotic cells, the plasma membrane is normal, but because there is only movement of PS, Annexin V is positive .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9024365	Each receptor subunit contains an N-terminal HA tag for extracellular detection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "receptor", "subunit", "contains", "an", "N-terminal", "HA", "tag", "for", "ex...
PMC11790599	The MCF10A cells were cultured in specific epithelial culture medium (CM-0525, Procell Co., Ltd.).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MCF10A", "cells", "were", ...
PMC7762347	Subsequently, the cells were washed twice with 2 mL cold PBS, centrifuged (1000 rpm, 4 °C, 5 min) and resuspended in cold PBS (0.5 mL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10938336	Although curcumin has anticancer properties, its poor stability has been a major obstacle in therapeutic uses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "curcumin", "has", "anticancer", "prop...
PMC11435360	Also, future studies should consider mechanistic details, such as signaling pathways or molecular targets specifically affected by the combination therapy used in our study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11543885	Additional washes can be applied in this protocol to remove non-specific background from the beads, including washes with 2% SDS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", ...
PMC9429973	Aims: To evaluate early NK reconstitution and its effects on HSCT outcomes and related factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "evaluate", "early", "NK", "re...
PMC9429973	Methods: Cells expressing the MLL/AF4 fusion were treated with an MLL/AF4 (siMA6) or control (siMM) siRNA through electroporation or encapsulation by various LNP formulations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10571053	As shown in Figure 3A, while UO-31 cells do stain positively with the UIC-2 antibody, as shown by increased staining with the UIC-2 antibody (orange histogram), the two knockout clones, B11 and 1F4, no longer react with the antibody, as detected by flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591038	Recently, lactoferrin has been suggested as a neuroprotective agent because the intranasal delivery of lactoferrin into AD mice can augment α-secretase-dependent APP processing through the ERK1/2-CREB and HIF-1α pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7039683	A meta-analysis of OFC several GWASs in several populations and a single OFC GWAS in Han Chinese identified lead SNPs adjacent to the KRT8 and KRT18 genes (Leslie et al., 2017; Yu et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11496491	The comparison results of the expression of verified genes in the two groups of samples are shown in Fig. 10.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "comparison", "results...
PMC9429973	M. Trněný, L. Fogliatto, F. Gardner, I. Flinn, J.-F. Larouche, C. Haioun, M. Canales, H. Goto, R. Hajek, G. Salles, J. Qiu, A. Campinha-Bacote, M. Yan, R. Kothari, G. Man, D. Sahin, J. Hirata, C. Lee, H. Tilly, C. Flowers Charles University General Hospital, Prague, Czechia; UFRGS, Porto Alegre, Brazil; Florida Cancer ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5916734	Reduction of K > O to KH2 in vertebrate cells is catalyzed by the VKOR enzyme complex or VKORC (vitamin K oxidoreductase complex), the integral protein (vitamin K 2,3-epoxide-reductase complex subunit 1 (VKORC1 [EC 1.17.4.4]) being its main component) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11750712	As of 28 April 2023, diagnostic material from 76 patients with r/r PTCL (PTCL-NOS, AITL or ALCL) was screened by NGS or IHC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10729469	V4XP-3032.	[ { "tags": [ "O", "O" ], "tokens": [ "V4XP-3032", "." ] } ]
PMC11122631	For the evaluation of one indicator of medicinal chemistry (Pan Assay Interference Structures (PAINS)), only two compounds (3 and 8) caused alerts (Table S20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11632064	The impact on viability was low, with Rho-0 cells having ∼14% lower viability than parental MeWo cells, and it is not possible to segregate genotoxic and mitochondrial-specific effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The study includes two cohorts: 1) patients with AdvSM treated with midostaurin starting from Jan 2016.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "study", "includes", "two", "coh...
PMC11474209	As a result, a greater current output was detected .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "result", ",", "a", "greater", "current", "output", "was", "detected", "." ]...
PMC7229095	So, non or low producer cells generally show the high growth rate rather than high producer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "So", ",", "non", "or", "low", "p...
PMC11761919	Viral load in liver.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Viral", "load", "in", "liver", "." ] } ]
PMC10033453	Owing to vast heterogeneity in responses, the 5-year survival rate for advanced stage soft tissue sarcoma or bone sarcoma is less than 20%, emphasizing the need for novel therapeutic strategies for the treatment of refractory sarcoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11673128	Therefore, in this treatment setting, the primary driver of enhanced phagocytosis would be the suppression of upregulated CD47, which significantly affects phagocytic regulation following prolonged TKI exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240	The samples were subjected to gel electrophoresis and Western blotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "samples", "were", "subjected", "to", "gel", "electrophoresis", "and", "Western", "blottin...
PMC11228511	The quantification results were exported to GraphPad Prism software for graphical illustrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "quantification", "results", "were", "exported", "to", "GraphPad", "Prism", ...
PMC10158546	ReN cells were passaged up to a maximum of 15 times before a new vial of cells was thawed from liquid Nitrogen storage.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11707832	Figure 1.MAN2B1 expression across various immune cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "1.MAN2B1", "expression", "across", "various", "immune", "cell", "types", "." ] } ]
PMC3274243	This technology could provide an alternative to conventional end-point assays used in the fields of chemotherapy, toxicology and drug discovery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "technology", ...
PMC7452526	The higher concentration of CN–Ag (30 μgmL) was found to be very toxic against Caco-2 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "The", "higher"...
PMC10968586	Treatment of T-ALL cell line CCRF-CEM with HT concentrations up to 1000 μM produced a dose-dependent reduction in cell viability (EC50 = 338 μM), flanked by the increase in caspase 3/7 activity .	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371627	Histological examination after biopsy of the left gastrocnemius muscle with hematoxylin and eosin staining, myosin slow and myosin fast staining revealed severe atrophy of skeletal muscle with vacant fat (black arrow) and surplus of connective tissue, but without signs of inflammation, rimmed vacuoles or ragged red fib...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10938336	Similarly, 3,5-dibenzyloxybenzyl bromide demonstrated a robust binding affinity of −8.32 kcal/mol, with interactions involving Phe A96 and Leu A97 residues of CASP3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9841531	Hydrolyzation with sodium hydroxide yielded product 2-(3-formyl-1H-indol-1-yl) acetic acid (15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hydrolyzation", "with", "sodium", "hydroxide", "yielded", "product", "2-(3-formyl...
PMC11365983	We first asked if there was clinical evidence that alterations to FOXC1 impaired cilia function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "first", "asked", "if", "there", "was", "clinical", ...
PMC9429973	Results: Table 1 shows the main patients’ characteristics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Table", "1", "shows", "the", "main", "patients", "’", "characteristics", "...
PMC10831439	For instance, the calculated cytotoxic activity against SEM at a 5:1 ratio (E:T) achieved 6.8%±1.2% (untransduced iNKT cells) and 84.3%±8.6% (CD19-CAR-iNKT cells), while for Raji cells, it was 7.2%±4.1% (untransduced iNKT cells) and 65.8%±4.2% (CD19-CAR-iNKT cells).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11464982

NA: not analysed.

[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "NA", ":", "not", "analysed", "." ] } ]

PMC10547921

Chemical structures of tubulysin analogs 28–34; (B) Binding mode of compound 30 in complex with tubulin (PDB code 6Y4N).Figure 6 Design and SAR analysis of tubulysin analogs. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11754432

In line with previous reports in keratinocytes , Western analysis of STAT1 phosphorylation was performed following 3 h of EGFR inhibition (Fig. S6) revealing an increase in STAT1 phosphorylation to a similar level found with ALOX15B silencing.

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PMC11591794

The expression of selected genes and housekeeping genes were analyzed in a Q-PCR device (Bio-Rad CFX96).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "selected", ...

PMC10858941

Viability staining shows in green alive cells and in red dead cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Viability", "staining", "shows", "in", "green", "alive", "cells", "and", "in", ...

PMC7171147

Secondly, malonyl COA might be compartmentalized to prevent inhibition of CPT1A so that FAO is uninterrupted or rapidly utilized to meet cancer cells’ high demand for energy and/or biomolecules.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11301095

CSF adenosine deaminase was 7 U/L. The CSF characteristics suggested bacterial meningitis.

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PMC9429973

Univariate analysis of each MIPSS70 variable on OS was carried out, with statistically significant differences being confirmed for all variables except fibrosis grade and HMR mutations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11747467

A power value of β = 10 was chosen to construct a scale-free coexpression network ( Supplementary Figure S2B ).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "power", "value", ...

PMC11367939

ATG9A is the only integral membrane protein among core autophagy-related (ATG) proteins.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ATG9A", "is", "the", "only", "integral", "membrane", "protein", ...

PMC9878278

Forward and reverse primer sequences used for TGF-β family members, STAT1 and IRF7 are shown in Table 1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Forward", "and", "reverse", "prim...

PMC10523483

NSCLC cells with higher ROS levels are more vulnerable to ROS-inducing agents (11), and the higher GSH levels are associated with chemoresistance (12).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7887261

P-value < 0.05, **P-value < 0.01, n.s not significant (P-value > 0.05).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P-value", "<", "0.05", ",", "*", ...

PMC11391695

Every experimental procedure was conducted in strict adherence to the pertinent regulations and institutional protocols established by Nantong University.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Every", "experimental", "procedure", ...

PMC11365427

Similarly, phenylalanine-deprivation diets influenced mouse body weight, which remained stable and within acceptable limits (Fig. 4G).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", ...

PMC7090062

In accordance with the results of western blot analysis described previously, we found that the miR-30a mimic suppressed the formation of IM-mediated LC3 puncta and autophagic vacuoles compared with those detected in the IM, whereas the miR-30a inhibitor mediated the opposite effects (Fig. 4b, c).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10560648

Jurkat cell growth was inhibited by 48.9% after 72 hours of treatment with 250µg/mL Cassiopea andromeda venom.

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PMC11711127

Replicative senescence is a process that occurs as a result of many rounds of replication leading to shortened telomeric length and subsequent senescent state to prevent its potential progression toward malignancy (76).

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PMC11635519

Our method could help identify novel GPCR-activating peptides for structure–function or drug discovery studies.

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PMC11700165

In resting cells, SYK retains a “closed” conformation, where the tandem SH2 domains fold together with the kinase domain adapting a so-called “linker-kinase sandwich”.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11759751

In this study, we investigated whether the anti-B-NHL ability of CD19 CAR T cells could be enhanced by the pretreatment of chidamide.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...

PMC9429973

Regarding toxicity, cumulative incidence of treatment-related mortality (TRM) (including transplant-TRM) at 5 years was 17% (95% CI 14-20).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10671321

As shown previously in rodents, pathogenic variants in the CTD can lead to the near absence of AChE at the synapse or just to a reduction of AChE activity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8740518

Statistical analysis was performed using R package “limma” to screen for statistically differentially expressed genes (P-value <0.05) and to calculate fold changes of selected genes.

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PMC10858941

Cell lysates were separated by SDS-polyacrylamide gel electrophoresis and transferred to a polyvinylidene difluoride (PVDF) membrane (Merck Millipore, Massachusetts, USA; IPVH00010).

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PMC11779605

ES-2/GFP-luc (hereafter called ES-2) ovarian cancer cell line (17) (gifted by Dr. Branimir I. Sikic, Standford University, Stanford, CA, USA) was authenticated by the short tandem repeat method and proven to be negative for mycoplasma, Hantaan, and lymphocytic choriomeningitis viruses prior to use.

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PMC11224020

Genes were considered differentially expressed if the fold change value was ≥1.5 and the P value was ≤0.05.

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PMC10994876

These genes are known to be involved in important cellular processes such as apoptosis and cell division, and they have previously been used as indicators of YAP activity at the transcriptional level (Mugahid et al. 2020).

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PMC9910796

The absence of unwanted mutations in the resulting plasmid pRepgus72I was verified by conventional Sanger sequencing.

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PMC10958426

Qubit and Qsep100 were used to measure DNA concentration and fragment length of each library, respectively.

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PMC11806182

Notably, testosterone was correlated with the up-regulated genes, while two phytoestrogens, enterolactone and coumestrol, were also associated with the up-regulated gene set.

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PMC11451940

The data were collected using a BD FACSVerse flow cytometer (Becton Dickinson, USA) in three separate experiments, each performed in duplicate, with at least 5 × 10 events recorded for each sample.

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PMC11515150

Expansion of NK cells with IL-2 combined with IL-15 or without IL-15 for 14 days (n = 3, left panel), and cell viability of NK cells with different concentrations of IL-15 (n = 3, right panel). (

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PMC8978939

All procedures were approved by the Animal Care and Use Committee of the Hospital de Niños Dr. Ricardo Gutiérrez.

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PMC8806312

The Database for Annotation, Visualization, and Integrated Discovery (DAVID) 6.8 (https://david.ncifcrf.gov) was used for gene function analysis .

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PMC11726848

It is worth noting that we observe an increase in cell size after LDR irradiation by 1.5–2 times.

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PMC11594588

In physiological conditions, cellular DNA and the nucleobases are constantly exposed to ROS, which causes their oxidative damage.

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PMC11549062

Endosome and lysosome trajectories of cos7 cells with the treatments of Rab5 knockdown, PDGFR‐β knockdown, or both knockdowns. (

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PMC10734950

Afterward, they were resuspended in a pre-warmed mixture of carboxy-H2DCFDA and 1 x PBS, making a final concentration of 10 μM dye.

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PMC9429973

Based on IPSS, 78% of patients were in the low and intermediate 1 risk groups.

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PMC11790599

Images were captured on a microscope equipped with a Leica DFC310 FX digital color camera at a 20 × objective.

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PMC10955424

Crizotinib at 2 μM was combined in the appropriate samples as indicated (B).

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PMC11699465

Then TMEM199 interacting proteins (TIPs) were pulled down with an anti-TMEM199 antibody and identified using mass spectrometry.

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PMC11525028

These results demonstrated that NAT10 regulated ATF4 through ac4C modification and overexpression of ATF4 rescued proliferation and metastasis, which were impaired by NAT10-KO.

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PMC11623887

They found that as cells differentiated, GATA-1 expression increased, and leading to the accumulation of nuclear GATA-1 protein.

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PMC11087055

See also Video 1 and Figure 1—source data 1.

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PMC6803987

The membrane was blocked in 5% skim milk for 2 h, and incubated overnight at 4 °C with rabbit anti-HBx (1:500) and rabbit anti-GAPDH (1:5000).

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PMC10887351

The main mechanism responsible for the β3-AR-induced cardio-protective effect was shown to be the NOS activation and production.

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PMC9429973

Image: Summary/Conclusion: These results clarified the comprehensive immune structures including novel tumor-specific markers in TFH lymphoma.

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PMC10529414

.

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PMC11063646

94517.

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PMC9596868

Following the incubation, 2 μl PI (BD Biosciences, Cat no. 556547, 51-66211E) was added to the cells.

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PMC9927933

However, the underlying mechanism by which UBE2C suppresses autophagy in lung cancer cells, and whether UBE2C plays an in vivo oncogenic role during lung tumorigenesis, are unknown.

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PMC11672142

Table 1 tabulates the calculated averages of GI50 and TGI (the Supporting Information includes the full testing results including the LC50 values in Table S2 and the dose–response curves of the nine different panels of cell lines in Figure S18).

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PMC11366496

Collectively, RNF122 enhances tumor development through JAK2/STAT3/c‐Myc signaling axis activation.

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PMC9429973

We performed WES of DNA samples from five patients and their parents.

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PMC11240448

We determined causal connections within the core networks and developed interpretable mechanistic models that elucidated the drivers of cell phenotypes.

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PMC11786704

H&E staining of wound sections on day 14, showing tissue regeneration. (

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PMC11768927

Other oncolytic viruses, like vaccinia virus, can be utilized in combination with VSV to improve the efficacy of virotherapy.

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PMC10604092

This medium was supplemented with 10% fetal bovine serum, 2 mmol/L L-glutamine, 100 U/mL penicillin, and 100 µg/mL streptomycin and the cells were cultured in 5% carbon dioxide at 37 °C.

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PMC9784246

Boswellia serrata and Viscum album extracts, for example, have passed laboratory investigations and are now undergoing clinical trials .

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PMC11770130

The serum samples were collected by centrifuging the whole blood cells of mice for 10 min at 4000 rpm and stored in a deep freezer.

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PMC11617590

In early apoptotic cells, the plasma membrane is normal, but because there is only movement of PS, Annexin V is positive .

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PMC9024365

Each receptor subunit contains an N-terminal HA tag for extracellular detection.

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PMC11790599

The MCF10A cells were cultured in specific epithelial culture medium (CM-0525, Procell Co., Ltd.).

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PMC7762347

Subsequently, the cells were washed twice with 2 mL cold PBS, centrifuged (1000 rpm, 4 °C, 5 min) and resuspended in cold PBS (0.5 mL).

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PMC10938336

Although curcumin has anticancer properties, its poor stability has been a major obstacle in therapeutic uses.

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PMC11435360

Also, future studies should consider mechanistic details, such as signaling pathways or molecular targets specifically affected by the combination therapy used in our study.

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PMC11543885

Additional washes can be applied in this protocol to remove non-specific background from the beads, including washes with 2% SDS.

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PMC9429973

Aims: To evaluate early NK reconstitution and its effects on HSCT outcomes and related factors.

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PMC9429973

Methods: Cells expressing the MLL/AF4 fusion were treated with an MLL/AF4 (siMA6) or control (siMM) siRNA through electroporation or encapsulation by various LNP formulations.

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PMC10571053

As shown in Figure 3A, while UO-31 cells do stain positively with the UIC-2 antibody, as shown by increased staining with the UIC-2 antibody (orange histogram), the two knockout clones, B11 and 1F4, no longer react with the antibody, as detected by flow cytometry.

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PMC11591038

Recently, lactoferrin has been suggested as a neuroprotective agent because the intranasal delivery of lactoferrin into AD mice can augment α-secretase-dependent APP processing through the ERK1/2-CREB and HIF-1α pathways .

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PMC7039683

A meta-analysis of OFC several GWASs in several populations and a single OFC GWAS in Han Chinese identified lead SNPs adjacent to the KRT8 and KRT18 genes (Leslie et al., 2017; Yu et al., 2017).

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PMC11496491

The comparison results of the expression of verified genes in the two groups of samples are shown in Fig. 10.Fig.

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PMC9429973

M. Trněný, L. Fogliatto, F. Gardner, I. Flinn, J.-F. Larouche, C. Haioun, M. Canales, H. Goto, R. Hajek, G. Salles, J. Qiu, A. Campinha-Bacote, M. Yan, R. Kothari, G. Man, D. Sahin, J. Hirata, C. Lee, H. Tilly, C. Flowers Charles University General Hospital, Prague, Czechia; UFRGS, Porto Alegre, Brazil; Florida Cancer ...

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PMC5916734

Reduction of K > O to KH2 in vertebrate cells is catalyzed by the VKOR enzyme complex or VKORC (vitamin K oxidoreductase complex), the integral protein (vitamin K 2,3-epoxide-reductase complex subunit 1 (VKORC1 [EC 1.17.4.4]) being its main component) .

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PMC11750712

As of 28 April 2023, diagnostic material from 76 patients with r/r PTCL (PTCL-NOS, AITL or ALCL) was screened by NGS or IHC.

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PMC10729469

V4XP-3032.

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PMC11122631

For the evaluation of one indicator of medicinal chemistry (Pan Assay Interference Structures (PAINS)), only two compounds (3 and 8) caused alerts (Table S20).

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PMC11632064

The impact on viability was low, with Rho-0 cells having ∼14% lower viability than parental MeWo cells, and it is not possible to segregate genotoxic and mitochondrial-specific effects.

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PMC9429973

The study includes two cohorts: 1) patients with AdvSM treated with midostaurin starting from Jan 2016.

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PMC11474209

As a result, a greater current output was detected .

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PMC7229095

So, non or low producer cells generally show the high growth rate rather than high producer cells.

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PMC11761919

Viral load in liver.

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PMC10033453

Owing to vast heterogeneity in responses, the 5-year survival rate for advanced stage soft tissue sarcoma or bone sarcoma is less than 20%, emphasizing the need for novel therapeutic strategies for the treatment of refractory sarcoma.

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PMC11673128

Therefore, in this treatment setting, the primary driver of enhanced phagocytosis would be the suppression of upregulated CD47, which significantly affects phagocytic regulation following prolonged TKI exposure.

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PMC11683240

The samples were subjected to gel electrophoresis and Western blotting.

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PMC11228511

The quantification results were exported to GraphPad Prism software for graphical illustrations.

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PMC10158546

ReN cells were passaged up to a maximum of 15 times before a new vial of cells was thawed from liquid Nitrogen storage.

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PMC11707832

Figure 1.MAN2B1 expression across various immune cell types.

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PMC3274243

This technology could provide an alternative to conventional end-point assays used in the fields of chemotherapy, toxicology and drug discovery.

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PMC7452526

The higher concentration of CN–Ag (30 μgmL) was found to be very toxic against Caco-2 cell line.

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PMC10968586

Treatment of T-ALL cell line CCRF-CEM with HT concentrations up to 1000 μM produced a dose-dependent reduction in cell viability (EC50 = 338 μM), flanked by the increase in caspase 3/7 activity .

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PMC11371627

Histological examination after biopsy of the left gastrocnemius muscle with hematoxylin and eosin staining, myosin slow and myosin fast staining revealed severe atrophy of skeletal muscle with vacant fat (black arrow) and surplus of connective tissue, but without signs of inflammation, rimmed vacuoles or ragged red fib...

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PMC10938336

Similarly, 3,5-dibenzyloxybenzyl bromide demonstrated a robust binding affinity of −8.32 kcal/mol, with interactions involving Phe A96 and Leu A97 residues of CASP3.

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PMC9841531

Hydrolyzation with sodium hydroxide yielded product 2-(3-formyl-1H-indol-1-yl) acetic acid (15).

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PMC11365983

We first asked if there was clinical evidence that alterations to FOXC1 impaired cilia function.

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PMC9429973

Results: Table 1 shows the main patients’ characteristics.

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PMC10831439

For instance, the calculated cytotoxic activity against SEM at a 5:1 ratio (E:T) achieved 6.8%±1.2% (untransduced iNKT cells) and 84.3%±8.6% (CD19-CAR-iNKT cells), while for Raji cells, it was 7.2%±4.1% (untransduced iNKT cells) and 65.8%±4.2% (CD19-CAR-iNKT cells).

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