Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Methods: We generated single-cell derived, biallelic LINC01547 knock-out clones in Kasumi-1 cells using the CRISPR/Cas9 system with paired sgRNAs.
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PMC11684297
for 100 µg/ml), indicating degradation of amyloids in the 100 µg/ml treated sample up to 1.4-fold.
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PMC9412887
p < 0.05, ** p < 0.01. (
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PMC8164677
Additive effect was observed for all sequences of administration (0/0, 0/4 and 4/0 h) in A2780.
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PMC9014716
On the one hand, miR-491-3p inhibited ABCB1 mRNA expression at the post-transcriptional level by directly targeting the 3′-UTR region of ABCB1.
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PMC8481254
We subsequently investigated whether CA attenuated the increase in global O-GlcNAcylation and inhibited the suppression of liver cancer cell proliferation through CDK19.
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PMC11680562
The drug release profile of PXFCu6 showed a perfect fit with the Hixson-Crowell kinetic model, resulting in a high regression value of 0.9877.
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PMC9429973
The persistence of SC-U02 in human body is observed as an exploratory endpoint.
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PMC9429973
Newborn blood group was 0 Pos CcDee Kk and Direct antiglobulin test was positive (++++).
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PMC11633763
A portion of the sample was stored in a refrigerator at −80°C for protein immunoblotting and quantitative reverse transcription polymerase chain reaction (qRT‐PCR), while the remaining portion was fixed in 4% paraformaldehyde for immunohistochemical analysis.
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PMC11578343
Lat‐A (Abcam) was reconstituted in ethyl alcohol and added to MCF‐7 cell culture medium at a concentration of 1 µg mL. Cells were then incubated at 37 °C for 90 min.
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PMC11720107
Garlic (Allium sativum L.) is one of the oldest known useful plants, valued for thousands of years.
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PMC11640419
The synthesized compounds were incubated with Jurkat cells to evaluate the effect on the cell cycle, followed by an analysis of the signaling pathways involved in genotoxic stress and programmed cell death.
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PMC5025404
Proper assembly of the expression vector was verified by restriction analysis.
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PMC11742290
In this study, miR-132 (tumor progression marker) expression was enhanced in LGR5 + GCSCs and correlated with chemo-resistance in gastric cancer patients .
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PMC9275501
Wang et al. (2019d) prepared PTX-BA hybrid nanosuspension to induce early apoptosis of MCF-7 cells through the decrease of mitochondrial membrane potential (Jiang et al., 2015).
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PMC11653533
F. racemosa is local to Australia, Southeast Asia, and the Indian subcontinent, hence disseminated from external Himalayan ranges, Punjab, Khasia mountain, Chota Nagpur, Bihar, Orissa, West Bengal, Rajasthan, Deccan and South India to all over India (Paarakh, 2009, Shiksharthi and Mittal, 2011).
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PMC10761218
The ayurvedic plant Withania somnifera, a member of the Solanaceae family, has been used as a remedy for diverse health problems, including cancer.
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PMC8427838
Spectra were recorded in the centroid mode.
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PMC11509278
Another significantly different pathway in positive ion mode is the linoleic acid metabolism pathway, which is enriched with differentially abundant metabolites, such as phosphatidylcholine (PC32:1), 12, 13-dihydroxy-9Z-octadecenoic acid ((+/−)12(13)-DiHOME), and 13-hydroperoxylinoleic acid (13-HpODE).
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PMC9024365
GluK2/GluA1 chimeras.
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PMC11727907
Once confluence was reached, the cells were pre-treated for 1 h with 400 pmol/L Klotho (R&D System Inc., Minneapolis, MN, USA) and then exposed for 2, 4, and 24 h to 100 nmol/L IGF-1 (Life Technologies Italia, Milan, Italy) and processed for each analysis.
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PMC10958426
The DEGs are significantly enriched in interferon signaling, neutrophil degranulation, cellular response to cytokine stimulus and regulation of cell-cell adhesion (Figs. S7A and B).
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PMC9024365
Conversely, the co-expression of GluK2 with SD1 did not exhibit a clustering phenotype.
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PMC5673060
The reconstituted sample was mixed with 150 μl 60% acetonitrile/0.3% trifluoroacetic acid/25% lactic acid, added to an equilibrated spin tip and spun at 1000 x g for 10 mins.
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PMC11052306
The uptake of the dendriplexes in MCF-7 cells was more efficient with the first generation than with the zero-generation dendrimers.
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PMC11760643
HEK‐P2X7 cells were originally provided by Dr. Leanne Stokes (University of East Anglia, Norwich, UK) and were maintained in the same medium as HEK‐293 cells but containing 400 µg/mL geneticin.
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PMC8658661
An analysis comparing results of the transcriptome profiling of hepatic cell lines and tumor cells in HB and HCC showed significant differences in the level of DLK1 gene expression in HepG2 cells , which may be necessary for driving chemoresistance and potentiating malignancy in cancers.
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PMC11269792
The RIP assay was performed using the Imprint® RIP Kit (Sigma-Aldrich).
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PMC11674891
Consistent with these findings, our results show that GRPR induces the expression of several metastasis-related genes, including the oncogenes CRABP2 and FNDC4.
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PMC6771295
Recent studies have shown that the mitochondrial desuccinylase and demalonylase activities of SIRT5 regulate autophagy and mitophagy (50) and a small nuclear fraction of SIRT5 exist (17) that could be involved in the SIRT5 mediated transcriptional regulation of autophagic genes (34).
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PMC9014716
GAPDH was used for internal control. (
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PMC5963610
Control groups received the phosphate buffered saline (SSFT).
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PMC11467964
Then, the entire group (n = 259) was equally assigned to training cohort (n = 131), testing cohort (n = 128).
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PMC8609870
Studies on the correlation of gene polymorphisms in schizophrenia revealed that NTNG1 and its paralogues for NTNG2 gene may be related to the pathophysiology of schizophrenia [13–15].
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PMC11012313
To test this hypothesis, we used the Seahorse XF ATP Production Assay to assess the amount of total ATP generated in LMP2A-negative and -positive B lymphoma cell lines (BJAB and Ramos).
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PMC10976516
Cell-mediated delivery of VSV can be achieved using allogeneic or xenogeneic carrier tumor cell lines, proving that carrier cells can evade immune responses against OVs.
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PMC11317131
PE is first used to insert the 35 bp attB site at a desired genomic locus, such as ROSA26.
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PMC10820104
The 1D and 2D NMR spectra were recorded in CDCl3 and MeOD using Bruker Avance III 500 or 600 MHz NMR spectrometers (Bruker BioSpin GmbH, Rheinstetten, Germany).
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PMC11672881
The mixture was incubated on ice for 5 min and then neutralized with 50 µL of 15% NH4HCO3.
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PMC11699042
Finally, to expand our understanding of the scarcity of genomic and phenotypic cell line evolution in the context of EwS, we sought to analyze how our findings in A-673 cells (as one of the most widely used cell lines in EwS research) would compare to other EwS cell lines.
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PMC9429973
Service users may prefer more unequivocal language to definitively guide management.
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PMC10092581
The cytotoxicity parameters, in terms of IC50 obtained after 72 h of exposure to the MTT assay are reported in Tables 1 and S1.
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PMC11413393
Cells were transduced with Flag-miniTurbo-PRMT1v1 lentiviral supernatant for 48 h before media was changed and puromycin selection applied.
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PMC11806613
A-B Effects of OST-01 on the expression of key regulators of BCSC.
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PMC10547921
However, due to the instability of macrolide in blood circulation, its in vivo antitumor activity is not significant.
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PMC8751435
Cordyceps militaris extract (CME) is purchased from GENETERRA (CHINESE) CO.
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PMC11739484
GEPIA2 (http://gepia2.cancer-pku.cn/#index) is an advanced web-based platform that has transformed cancer genomics and gene expression analysis.
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PMC9429973
Results: Medical data for 157 CP-CML patients were assessed; the mean follow-up was 66.9 months, the median age at 3L initiation was 62.1 years, 56% were male, and 90% had major BCR-ABL1 rearrangement (among the 89 patients with mutation status assessed, 7 [8%] had BCR-ABL1 T315I mutation, 3 [3%] had M244V, and 3 [3%] ...
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PMC11489351
Replicate cells were also treated for 24 h with a gamma-secretase inhibitor (DAPT).
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PMC11665555
Experiments were performed in triplicate and densitometry was calculated with ImageJ (NIH).
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PMC11190062
TNFRSF17 mRNA expression relative to TBP was assessed by RT-qPCR in RPMI-8266 cells treated with LPS (0.1 µg/mL) and CpG (1 µM) for 6 and 24 hours.
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PMC9429973
Noteworthy, the most frequently used MPN-specific instruments were created by the same authors, who also were involved in clinical trials.
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PMC9684669
Compounds were added to the assay plates at indicated concentrations at 100 µL/well diluted in medium.
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PMC11201989
Here, we find that programmed death ligand 1 (PD-L1), an immune checkpoint protein and regulator of immune synapse formation, plays a role in the regulation of ciliogenesis.
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PMC11301242
5Analysis of possible mechanisms of ecDNA formation.(A) Circos plot of chromothripsis events involving multiple chromosomes in the lymphoma cell line A3KAW. (
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PMC11790599
P < 0.05; **P < 0.01; ***P < 0.001.
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PMC11609529
Apoptotic cells were detected using Annexin V/PI staining (BD Biosciences) following the manufacturer’s protocol.
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PMC11543853
Actin filaments attached to the tips of the membrane cones are visible.
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PMC11790599
It showed that TSL significantly increased NRF2 levels, as well as its downstream effectors NQO1 and HO-1 (Figure 5A).
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PMC10553757
Disclosure: T. Elajnaf: None.
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PMC11591030
Additionally, 150 μg/mL AOP significantly increased the expression of the Nrf2 and SOD genes, showing protective effects comparable to those of the VA treatment group (p < 0.05).
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PMC9429973
Factors such as gender, age, stage of the disease, ECOG status, the presence of B-symptoms at the onset of the disease, and the treatment regimen did not statistically significantly affect the two years OS and PFS from the diagnosis of HL in patients with HIV.
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PMC9429973
Image: Summary/Conclusion: SC Isa administered by OBDS shows a safety profile consistent with IV administration with no IRs and excellent local tolerability.
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PMC11063646
There were no signs of phase separation or macroscopic structural damage after freeze-thawing (Fig. 14).Fig.
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PMC9429973
40 pts had a related donor, 1 pt had an HLA-haploidentical donor and 45 pts had a non-related donor (NRD).
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PMC11635519
All peptides’ purity is higher than 90%.
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PMC8193046
For example, half of the A and G subclasses of ABC transporters have been identified as contributors in Alzheimer’s disease, correlating their downregulation or defective function with a negative disease development , .
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PMC10849234
After confirming degranulation capabilities in NLCs, we sought to determine if promyelocytic cells can be used as a genetically-tractable system to test neutrophil granule functions.
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PMC11457557
The overexpression of miR-216a protects against human retinal microvascular endothelial cell (HRMEC) injury in DR by downregulating the Nitric oxide synthase/Janus kinase/signal transducer and activator of transcription (NOS2/JAK/STAT) axis .
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PMC6803987
In addition, real-time PCR was used to detect the level of HBV DNA in the supernatant, and the results showed that esculetin significantly reduced the expression of HBV DNA in the supernatant of the cells compared with the negative control group.
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PMC11046454
As indicated by the double positive signal of EGFP and Cy5 (from FITC-DNA-Cy5), the cellular transfection efficiency of anti-FITC CAR was about 35% (Figure S15).
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PMC11590870
This test has been used to predict the antioxidant activity of various molecules of plant origin but less so for hydrolysates.
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PMC11705862
We showed that the two splice variants of CD59 interact with both VAMP2 and SNAP-25 as well as with insulin granules.
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PMC11122631
The major compound 3 showed cytotoxic activity against the Ca9-22 cells with the IC50 value of 2.11 ± 0.03 μg/mL, which echoes the cytotoxic effect of the coral extract.
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PMC5811757
Based on the results of this study, it is concluded that the CRISPR-based systems, used in the present study, effectively down-regulated the target gene and acted as an ideal and cost-effective tool for gene editing of A2780/ADR cell line resulting in restoration of nonmalignant phenotype.
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PMC9429973
.
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PMC11718109
The SLC6A3 (DAT) was n-terminally tagged with mCherry in the pDEST-CMV-N-mCherry (#123215) destination vector.
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PMC9046263
The adherent A172 glioblastoma cell lines (B) and neurosphere patient-derived glioblastoma cell lines, GBM28 (C) and GBM43 (D) have increased levels of HML-6 transcripts compared to astrocytes.
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PMC9429973
A further detailed study is required to confirm our preliminary results.
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PMC9429973
In the total study population, 55/71 pts (77%) achieved CR after (blina) cons-1.
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PMC6114978
To begin addressing whether hypermethylation of these promoters is functionally significant, we treated sarcoma cell lines with 10 μM 5-azacytidine (a covalent inhibitor of DNA methyltransferase I ) for 4 days.
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PMC11345828
Synthesis of the trimethyl pyrimidine series (Scheme 3) began with conversion of 5-bromo-4,6-dimethylpyrimidine (51) to methyl alcohol 52 by treatment with ammonium persulfate in methanol.
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PMC9429973
Consecutive data-base research and annotation according to NCT/DKTK MASTER evidence levels was performed in order to identify molecularly stratified treatment strategies.
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PMC9436459
Due to their undefined absolute configurations of C-22", 14 and 15 were randomly assigned the R*- and S*-configurations, respectively, for the distinguishment of them.
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PMC11306331
We also implemented a chemogenetic variant of the MBP recruitment system that takes advantage of the FRB domain on our 3xFUS construct for rapamycin-based protein dimerization (Fig. 1E).
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PMC10530622
Genetic (primary hyperoxaluria) and non-genetic (e.g., diet, microbiota, renal and metabolic disease) reasons underlie elevated plasma concentrations and tissue accumulation of oxalate, which is toxic to the body.
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PMC11665584
Explanation of statistics can be found in Supplemental Methods.
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PMC6889484
Vectors pA3dr(DK) and p3Gdr(DK) express the A3 and 3G portions of the A3G-D128K direct repeat, respectively. (
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PMC10237474
Despite the titer difference, levels of clipped species were significantly reduced in conditioned medium (CM) derived from Expi293F cells (S2C Fig).
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PMC9429973
ADE incidence decreased over time.
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PMC11306331
A FUS, EWS, and TAF15 all contain an N-terminal disordered domain, gray box.
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PMC11224020
Data were analyzed by Kruskal–Wallis test; ****P < 0.0001.
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PMC9429973
Adverse events (AEs) and treatment exposure are shown in the Table.
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PMC11640247
Future studies aiming at further mapping the RAC3 signaling network and understanding how pathogenic variants perturb these pathways may shed light on the pathophysiology of atypical clinical phenotypes and open new avenues for the potential development of targeted therapies.
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PMC11098378
Following these observations, we repeated these knockdown experiments to determine impacts on viral titers.
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PMC11739484
This data is consistent with prior research that reinforces the notion that alterations in promoter methylation play a significant role in the dysregulation observed in cancer patients.
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PMC11750696
When the capacity for UPR-mediated compensation is overwhelmed, it triggers apoptosis in β cells.
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PMC11659921
Heatmap of immune checkpoint‐related gene expression. (
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PMC6450504
Nucleic acid (1 µg) was loaded onto a 0.8% agarose gel, and electrophoresis was performed using an E-Gel electrophoresis system (Life Technologies, Carlsbad, CA), followed by evaluation of the bands under UV light.
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