OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC8633974	The pX333 used was a gift from Andrea Ventura (Addgene plasmid #64073) http://n2t.net/addgene:64073 ; (Addgene #64073) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pX333...
PMC11792888	The R. junceus scorpion venom was analyzed by reversed-phase high-performance liquid chromatography (HPLC) using a C18-phase reverse column (Intersustain C18, pore size 5 µm, column size 4.6 mm I.D. x 250 mm.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755624	Thus, the precise role of MALAT1 could be context-dependent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "the", "precise", "role", "of", "MALAT1", "could", "be", "context-dependent", ...
PMC11711871	The vascular rings were progressively brought to their optimal resting tension by two cycles of 2.6 g stretching, equilibration, and washing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11342785	Indeed, the ability of TPPP’s MT-binding domain to cooperate so effectively with the IDRs of DDX4—an RNA helicase (58, 59)—indicates considerable plasticity in the mechanisms by which condensate-formation can synergize with MT organization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Treated with Azacitidine combined with HAG regimen (azacytidine 75mg/(m·d), iH D1-7+ homoharringtonine 1mg/(m·d) D2-8+ cytarabine 10mg/m iH, D2-8+ G-CSF 200ug / (m·d) iH D1-8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10840195	Changes in the fluorescence area of tumour cells in different groups are shown in figure (A), and the tumour fluorescence area was measured by ImageJ (B) An in vivo zebrafish model verified the effect of Twist overexpression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10243817	Here, we found decreased phosphorylated SMAD2 (p-SMAD2) levels in NP tissues from patients with CRSwNP, especially in the patients with eosinophilic type, but increased p-SMAD2 levels in diseased sinus mucosa tissues from CRSsNP compared with nasal tissues from controls (Figure 5A), suggesting an overall reduced TGF-β ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190538	According to the literature, negative zeta potential has been linked to the improved biocompatibility than positive zeta potential .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "literat...
PMC11144382	Scale bar represents 50 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "represents", "50", "μm", ".", "(" ] } ]
PMC11519583	Total RNA was extracted from cultured cells using Sepasol-RNA I SuperG (Nacalai Tesque), and its quality was assessed using a NanoDrop spectrophotometer (Thermo Fisher Scientific).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	HPLC detection of HbH (β4), a hallmark of HbH disease, is observed in hemolysis products from all non-transduced a-thal erythroblasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11787651	HeLa cells were plated a day earlier at a density of 1 × 10 cells/10 ml in four 10-cm dishes at 37 °C.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC11409031	≤0.05, ≤0.01, ≤0.001, ***≤0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "≤0.05", ",", "", "", "≤0.01", ",", "*", ...
PMC11286266	Schematic representation of the strategy for targeted integration at the cgROSA26 safe-harbour locus in the CHO genome, mediated by CRISPR/Cas9-mediated homology-directed repair (HDR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The response was also relatively lasting in follow-up after drug withdrawal.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "response", "was", "also", "relatively", "lasting", "in", "follow-up", "after", ...
PMC8701144	The HEK293-STF/Ren cell line has a genomically integrated β-catenin responsive STF Firefly luciferase reporter gene together with a constitutive active control Renilla luciferase reporter gene and represents a robust assay for quantifying changes in WNT/β-catenin signaling activity .	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6684588	The knee was securely fastened to an immobile horizontal support.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "knee", "was", "securely", "fastened", "to", "an", "immobile", "horizontal", "support", ...
PMC9712534	Experiments with ICRF-187 were performed on EGFP-TOP2B H58Y as described in (a). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experiments", "with", "ICRF-187", "were", "performed", "on", ...
PMC11266100	However, various cell lines exhibit different susceptibility to PEF and certain cell lines present challenges in achieving long-term transfected clones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "v...
PMC11476106	Our research is focused on alternative 3D models that are simple and quick to manufacture in terms of composition and structure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "research", ...
PMC11509309	Purealidin Q (1), aplysamine-2 (2), and aplysamine-1 (5) were able to reduce PrP propagation with IC50 values of 3.3, 5.5, and 6 µM, respectively (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10772747	In contrast, treatment with DOX and 1,4 naphthoquinone did not affect the cell cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "treatment", "with", "DOX", "and", ...
PMC10669966	The cytotoxic effect of PDE3A modulators is based on their ability to induce complex formation between PDE3A and SLFN12, and drug sensitivity positively correlates with expression levels of the two proteins .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11665555	An integrated pathway analysis combining RNA-Seq and metabolomics showed a robust nucleotide biosynthesis signature in the 5637 GR cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "An", "integrated", "pathway", ...
PMC10040136	The investigation encompassed the examination of MSC migration towards tumor tissue and the impact of MSC on the survival of GIST cells under IM treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11572213	The numbers and viability of TET2-knockdown HL-60 cells were decreased in low glutamine-containing medium, but the viability of TET2-knockdown HL-60 cells was higher than that of control cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "...
PMC10547921	In August 2022, Pepaxto® was approved by the EMA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "August", "2022", ",", "Pepaxto", "®", "was", "approved", "by", "the", "EM...
PMC11739696	This was done by extracting the cellular RNA from untreated and Co3O4NPs-treated cells following the manufacturer’s instructions of Thermo Fisher Scientific’s GeneJET RNA Purification Kit (USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	H Transiently overexpressed DN-p53(S46G) caused WWOX dissociation from the endogenous TRAF2/WWOX/p53 complex at 4℃.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", "Transiently", "overexpressed", "DN-p53(S46", ...
PMC9429973	At the baseline, the most frequent defects were mutations in NOTCH1 (15 %), SF3B1 (15 %), ATM (12 %) genes, and 13q- (56 %), 11q- (19 %) and tri12 (15 %).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803918	While the initial outcomes of γδ-T exosome-based therapy showed promise, our preliminary study uncovered the inefficacy of a single treatment with γδ-T exosomes in halting the progression of highly malignant cancers like melanoma in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746948	To explore this, we performed the proteomic analysis of palmitoylated proteins in hydroxylamine-treated or untreated A375 melanoma cells using the alkyne-tagged palmitic acid analogue Alk14 as a metabolic label, particularly focusing on proteins associated with ferroptosis (Fig. 2a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730320	IL-7 is critical for the generation and maintenance of CD8+ memory and naive cells demonstrate high levels of IL-7Rα expression which gradually decreases during differentiation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11806182	B Boxplots showing the top ten significantly changed genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Boxplots", "showing", "the", "top", "ten", "significantly", "changed", "genes", "." ] } ]
PMC11705630	To elucidate the underlying mechanism of the effect of GLDC on RCC progression, we chose ACHN and Caki-2 with stable knock-downed GLDC and conducted further experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "...
PMC9429973	G. Garcia-Manero, E. S. Winer, D. J. DeAngelo, S. Tarantolo, D. A. Sallman, J. Dugan, S. Groepper, A. Giagounidis, K. Götze, K. H. Metzeler, C.-C. Li, L. Zhou, E. Martinez, M. Lane, R. von Roemeling, M. Bohme, A. S. Kubasch, A. Verma, U. Platzbecker Luekemia, MD Anderson Cancer Center, Houston; Dana-Faber Cancer Instit...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747160	Griffithsin is a small (~12.8 kilodalton), dimeric, red algae-derived lectin that displays inhibitory activity against a wide variety of viruses, ranging from Human Immunodeficiency Virus (Retroviridae family) to Herpes Simplex Virus (Herpesviridae family), Japanese Encephalitis Virus (Flaviviridae family), Human Papil...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The most common non-SCD-related treatment-emergent AEs were diarrhea, headache, and rash; 37.0% (n=80) of patients reported ≥1 non-SCD-related AE, and most AEs were mild in severity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10978090	After surgery, anti-PF4/H IgG increased until D23 (1.01 OD) and became negative again at D29 (0.29 OD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "sur...
PMC11295144	However, the surface or total expression of NL2 showed no difference between these conditions, indicating that other molecular mechanisms may mediate the observed cooperative interaction between NL2 and GABAARs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988808	Overexpression of CCDC25 inhibited the expression of downstream Hippo pathway proteins ITGA3 and CCND1 and promoted YAP phosphorylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overexpression", "of", "CCDC25", "inhibited"...
PMC8193046	In our previous study, we have explored different ligand-based approaches to validate C@PA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "previous", "study", ",", "we", "have", "explored", ...
PMC9429973	Results: In total, 40 patients with RRMM were enrolled into the study: median age – 64 years (range, 33–80), 35% males.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: This phase 1 dose escalation part (NCT04836507) was to evaluate the safety (DLT, MTD), PK and preliminary efficacy (objective response rate and duration of response) in patients with r/r LBCL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802855	Additionally, single-cell RNA sequencing of MM patient samples revealed a strong co-expression of CXCL7 and JAK/STAT3 in the mm03 subgroup (Fig. 2K).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11635087	The black arrow indicates a CHO cell with chloroplasts. (	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "The", "black", "arrow", "indicates", "a", "CHO", "cell", "with", "chloroplasts", ".", ...
PMC11742047	Apoptosis signaling, in contrast to autophagy and necrosis, is triggered either by death receptors (extrinsic pathway) or by mitochondria (intrinsic pathway), where lipids play a pivotal role in both pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10890307	MCF-7 cells, a breast tumor cell line that can consume lactate, and non-transformed fibroblast cells (MRC-5) were included as controls.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], ...
PMC11737091	The tumor volume was calculated using the following formula: length × width2/2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tumor", "volume", "was", "calculated", "using", "the", "following", ...
PMC11604830	Typical examples are represented by (super)paramagnetic, , fluorine‐containing, or hyperpolarized probes for MRI/magnetic particle imaging (MRI/MPI) detection, chromophores/fluorophores for photoacoustic/fluorescence imaging, and radioisotopes for PET/single photon emission computed tomography (PET/SPECT) detection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	The reaction mixture was stirred for 1 h at 120 °C in a sealed flask.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reaction", "mixture", "was", "stirred", "for", ...
PMC9429973	Summary/Conclusion: Study recruiting in Q2 2022 in US.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Study", "recruiting", "in", "Q2", "2022", "in", "US", "." ] } ]
PMC11314247	HDACis have attracted the attention of oncology researchers, and more than 500 clinical trials have recently been initiated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HDACis", "have", "attracted", "th...
PMC9429973	Aims: This abstract will present the preliminary safety and efficacy results from Part B of the SGN35-027 study, which enrolled pts with Ann Arbor Stage II cHL with bulky mediastinal disease (defined as a single node or nodal mass ≥10 cm as determined by CT imaging), or Stage III or IV cHL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	The correlation we observed between condensate formation and MT bundling across native and synthetic TPPP variants suggests that regulatable condensation could provide a mechanism for controlling synMAP MT bundling activity in cellular contexts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In higher risk groups, the goal is to prolong survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "higher", "risk", "groups", ",", "the", "goal", "is", "to", "prolong", "su...
PMC11201989	Ciliary vesicle formation and protein trafficking are important steps in the hierarchy of cilia assembly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ciliary", "vesicle", "formation", "and", "protein", "trafficking"...
PMC10877303	The Canonical SMILES (simplified molecular-input line-entry system) for the screened plausible antiviral phytochemicals were retrieved from the PubChem database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Canonical", ...
PMC9429973	No difference in terms of HIPK2 expression was appreciated in the two groups, suggesting downregulation at post-transcriptional level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "difference", "in", "terms",...
PMC10926885	RT‐PCR primer sequences.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "RT‐PCR", "primer", "sequences", "." ] } ]
PMC11743414	Notably, as a tumor-suppressor gene on the X chromosome, FHL1 may be completely inactivated by a single gene or epigenetic abnormality on an active allele, which is inactivated by DNA methylation and has a high risk of being affected by environment [25–27].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786767	C: RO-3306 treatment disrupts mitotic progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ":", "RO-3306", "treatment", "disrupts", "mitotic", "progression", "." ] } ]
PMC6835428	While the approach is, in principle, interesting, it was not determined whether KSP can be considered an appropriate target in OC treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9985266	ERK and p38 have also been shown to be involved in autophagy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ERK", "and", "p38", "have", "also", "been", "shown", "to", "be", "involved...
PMC8864075	D,E) The inhibitions of siTWIST1 and reTFAE on wound healing (n = 3). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", ",", "E", ")", "The", ...
PMC8193813	The times to reach 95% of the reference concentration, t95, were 6.3 and 32.3s (relative standard deviation: RSD 8.2% and 11.8%), respectively, for the NO-D4 and NO2-D4 sensors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Amongst mutated pts, the presence of single versus multiple KIT or RAS mutation did not affect optimal PCR responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Amongst", "mutated", "pts", ...
PMC11127909	In our study, we found that EFHD1 can inhibit mPTP opening by fixing ANT3 in the m-state, promote mitochondrial functions and prevent cell death in a toxic environment, which contributes to promoting OS proliferation and drug resistance (Fig. 7).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615743	Similarly, the cells were incubated with the D‒DNA version of the logic device components.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "the", "cells", "were", "incubated", "with...
PMC9581083	Wu Youke’s Plague Theory and Dai Tianzhang’s Guang Plague Theory proposed that “Jing Fangbaidu San” is a useful formula for those who want to sweat and cool down.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8753818	This host cell is the cellular factory of about one third of all biopharmaceutical products approved by FDA since 1982 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "host", "cell", ...
PMC11012012	A flow cytometry analysis of Shlapatska et al. (2001) revealed that all studied B lymphoblastoid cell lines (CESS, MP-1, T5-1, 6.16, and RPMI-1788) and cell lines from patients with XLP (IARC 739, XLP-D, XLP-8002, and XLP-8005), expressed high levels of SLAMF1/CD150.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine"...
PMC9429973	In our phase 1 study in normal healthy volunteers, BLU-263 was safe, with linear pharmacokinetics across all tested doses and a half-life allowing once-daily dosing, and thus supporting continued development for patients with SM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10523483	Histones are involved in regulating antioxidant factors that contributes to cell homeostasis and tumor progression (15, 16).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Histones", "are", "involved"...
PMC11718109	While both VMAT1 and VMAT2 are known to localize to secretory vesicles like DCVs in neuroendocrine cells, it is generally believed that dopamine-containing vesicles in neurons are morphologically identical to the VGLUT- and VGAT-containing SV counterparts: clear vesicle clusters with a vesicular diameter of about 40 nm...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4270159	72 hr after treatment, fix cells in 4% paraformaldehyde (PFA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "72", "hr", "after", "treatment", ",", "fix", "cells", "in", ...
PMC11228511	After 48 h, cells (with or without Dox) were fixed with 4% paraformaldehyde in PBS for 10 min at room temperature and permeabilized with 0.3% Triton X-100 in PBS for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11537649	Lnc NEAT1 overexpression is reported in many solid tumors closely correlated with a poor prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lnc", "NEAT1", "overexpression", "is", "reported", "in", "m...
PMC10243817	We found that MEX3B preferentially bound to the 3′ UTR of TGFBR3 mRNA in HNECs (Figure 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "that", "MEX3B", ...
PMC10940855	Importantly, gRNA-EFNB2 multiple myeloma cells demonstrated markedly decreased sensitivity to chemotherapy agents, bortezomib and dexamethasone (Fig. 4H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", ...
PMC11655536	In this study, we observed increased LMP in the HA-treated MM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "observed", "increased", "LMP", "in"...
PMC4360730	Treatments have been annotated to ChEBI (e.g. 20-hydroxyecdysone—CHEBI:16587 and estradiol—CHEBI:23965).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatments", "have", "been", "annotated", "to", "ChEBI...
PMC11087055	Strikingly, in the aphidicolin-treated embryos (n=4), the polonaise movements initiated but were maintained for a shorter period, 2.2±1.2 hr (control 6.5±1.2 hr, p=0.0038, Figure G-G’”, I-I’”, and Video 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519788	Wild-type luciferase reporter containing this evolutionarily conserved region (-122 to +705 bp; Figure S4J), and four mutated reporters (with mutations on each VEZF1 binding site) were constructed (Figure 7K).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9000591	In particular, C. speciosa was reported as rich in saponins, flavonoids, phenolic glycosides, polysaccharides, and formononetin, which revealed numerous biological benefits for humans .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5716223	CS citrate synthase, GAPDH Glyceraldehyde-phosphate-dehydrogenase, NGF nerve growth factor, αBcry αB-crystallin, JNK c-Jun N-terminal kinases, NFκB nuclear factor kappa-light-chain-enhancer of activated B cells, p75 neurotrophin receptor p75 As summarized in Fig. 3e, our results demonstrate that p75 is sufficient to me...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9424261	F Reciprocal IP experiments for detecting GSS, MDM2 and SYVN1 in Bel-7402 and Bel-7404 cells which HERPUD1 were overexpressed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "Reciprocal"...
PMC10847511	P values were corrected for multiple testing using the Holm method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "values", "were", "corrected", "for", "multiple", "testing", "using", "the", "Hol...
PMC8427838	MTs are cytoskeletal filaments composed of heterodimers of α- and β-tubulin subunits and are critically important for chromosomal segregation, intracellular transport, cell division, cell motility and cell morphogenesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	The negatively charged phosphates along the CT of CXCR4 may interact with a positively charged surface or surfaces on SNX9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "negatively", "charged...
PMC11790971	Scikit-learn (version 0.23.2) was used to implement the ML model and calculate evaluation metrics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scikit-learn", "(", "version", "0.23.2", ")", "was", ...
PMC8097906	The images of invaded cells were taken the bright field microscope (CKX53, Olympus, Tokyo, Japan) and cells were counted with the software CellSens Entry (Olympus, Tokyo, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	DARPins were injected intravenously three times per week for two weeks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DARPins", "were", "injected", "intravenously", "three", "times", "per", "week", "for", ...
PMC11481779	The example shows chr1:29 500 000–31 500 000 from mouse predicted by the human model Results of applying the human model to the mouse data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11469524	Unique and razor peptides were included for quantification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unique", "and", "razor", "peptides", "were", "included", "for", "quantification", "." ] } ]
PMC11737091	Targeting a specific cell cycle protein seems to be an effective anticancer strategy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Targeting", "a", "specific", "cell", "cycle", "protein", "seems", "to", ...
PMC11470999	Streptavidin–biotin pull‐down and immunoblot assays analyses further showed that PF‐Biotin could simultaneously capture both CIP2A and VHL (Figure 6F), indicating the formation of a PF‒CIP2A‒VHL ternary complex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10723784	Ac‐DEVD‐AMC serves as the fluorogenic indicator for assaying caspase‐3/7 activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ac‐DEVD‐AMC", "serves", "as", "the", "fluorogenic", "indicator", "for", "assaying", "caspase‐3/7", ...
PMC11486946	The scheme in Fig. 6b, which was suggested from the five non-EGFR-TKI compounds, is effective for removing pathogenic cells that excessively express EGFR, a common phenotype of various cancers, by inducing cell death following EGFR internalization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8633974

The pX333 used was a gift from Andrea Ventura (Addgene plasmid #64073) http://n2t.net/addgene:64073 ; (Addgene #64073) .

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PMC11792888

The R. junceus scorpion venom was analyzed by reversed-phase high-performance liquid chromatography (HPLC) using a C18-phase reverse column (Intersustain C18, pore size 5 µm, column size 4.6 mm I.D. x 250 mm.,

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PMC11755624

Thus, the precise role of MALAT1 could be context-dependent.

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PMC11711871

The vascular rings were progressively brought to their optimal resting tension by two cycles of 2.6 g stretching, equilibration, and washing.

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PMC11342785

Indeed, the ability of TPPP’s MT-binding domain to cooperate so effectively with the IDRs of DDX4—an RNA helicase (58, 59)—indicates considerable plasticity in the mechanisms by which condensate-formation can synergize with MT organization.

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PMC9429973

Treated with Azacitidine combined with HAG regimen (azacytidine 75mg/(m·d), iH D1-7+ homoharringtonine 1mg/(m·d) D2-8+ cytarabine 10mg/m iH, D2-8+ G-CSF 200ug / (m·d) iH D1-8).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10840195

Changes in the fluorescence area of tumour cells in different groups are shown in figure (A), and the tumour fluorescence area was measured by ImageJ (B) An in vivo zebrafish model verified the effect of Twist overexpression.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10243817

Here, we found decreased phosphorylated SMAD2 (p-SMAD2) levels in NP tissues from patients with CRSwNP, especially in the patients with eosinophilic type, but increased p-SMAD2 levels in diseased sinus mucosa tissues from CRSsNP compared with nasal tissues from controls (Figure 5A), suggesting an overall reduced TGF-β ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11190538

According to the literature, negative zeta potential has been linked to the improved biocompatibility than positive zeta potential .

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PMC11144382

Scale bar represents 50 μm. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "represents", "50", "μm", ".", "(" ] } ]

PMC11519583

Total RNA was extracted from cultured cells using Sepasol-RNA I SuperG (Nacalai Tesque), and its quality was assessed using a NanoDrop spectrophotometer (Thermo Fisher Scientific).

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PMC9429973

HPLC detection of HbH (β4), a hallmark of HbH disease, is observed in hemolysis products from all non-transduced a-thal erythroblasts.

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PMC11787651

HeLa cells were plated a day earlier at a density of 1 × 10 cells/10 ml in four 10-cm dishes at 37 °C.

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PMC11409031

≤0.05, **≤0.01, ***≤0.001, ****≤0.0001.

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PMC11286266

Schematic representation of the strategy for targeted integration at the cgROSA26 safe-harbour locus in the CHO genome, mediated by CRISPR/Cas9-mediated homology-directed repair (HDR).

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PMC9429973

The response was also relatively lasting in follow-up after drug withdrawal.

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PMC8701144

The HEK293-STF/Ren cell line has a genomically integrated β-catenin responsive STF Firefly luciferase reporter gene together with a constitutive active control Renilla luciferase reporter gene and represents a robust assay for quantifying changes in WNT/β-catenin signaling activity .

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PMC6684588

The knee was securely fastened to an immobile horizontal support.

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PMC9712534

Experiments with ICRF-187 were performed on EGFP-TOP2B H58Y as described in (a). (

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PMC11266100

However, various cell lines exhibit different susceptibility to PEF and certain cell lines present challenges in achieving long-term transfected clones.

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PMC11476106

Our research is focused on alternative 3D models that are simple and quick to manufacture in terms of composition and structure.

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PMC11509309

Purealidin Q (1), aplysamine-2 (2), and aplysamine-1 (5) were able to reduce PrP propagation with IC50 values of 3.3, 5.5, and 6 µM, respectively (Figure 4).

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PMC10772747

In contrast, treatment with DOX and 1,4 naphthoquinone did not affect the cell cycle.

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PMC10669966

The cytotoxic effect of PDE3A modulators is based on their ability to induce complex formation between PDE3A and SLFN12, and drug sensitivity positively correlates with expression levels of the two proteins .

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PMC11665555

An integrated pathway analysis combining RNA-Seq and metabolomics showed a robust nucleotide biosynthesis signature in the 5637 GR cells.

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PMC10040136

The investigation encompassed the examination of MSC migration towards tumor tissue and the impact of MSC on the survival of GIST cells under IM treatment.

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PMC11572213

The numbers and viability of TET2-knockdown HL-60 cells were decreased in low glutamine-containing medium, but the viability of TET2-knockdown HL-60 cells was higher than that of control cells.

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PMC10547921

In August 2022, Pepaxto® was approved by the EMA.

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PMC11739696

This was done by extracting the cellular RNA from untreated and Co3O4NPs-treated cells following the manufacturer’s instructions of Thermo Fisher Scientific’s GeneJET RNA Purification Kit (USA).

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PMC11487720

H Transiently overexpressed DN-p53(S46G) caused WWOX dissociation from the endogenous TRAF2/WWOX/p53 complex at 4℃.

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PMC9429973

At the baseline, the most frequent defects were mutations in NOTCH1 (15 %), SF3B1 (15 %), ATM (12 %) genes, and 13q- (56 %), 11q- (19 %) and tri12 (15 %).

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PMC11803918

While the initial outcomes of γδ-T exosome-based therapy showed promise, our preliminary study uncovered the inefficacy of a single treatment with γδ-T exosomes in halting the progression of highly malignant cancers like melanoma in vivo.

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PMC11746948

To explore this, we performed the proteomic analysis of palmitoylated proteins in hydroxylamine-treated or untreated A375 melanoma cells using the alkyne-tagged palmitic acid analogue Alk14 as a metabolic label, particularly focusing on proteins associated with ferroptosis (Fig. 2a).

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PMC11730320

IL-7 is critical for the generation and maintenance of CD8+ memory and naive cells demonstrate high levels of IL-7Rα expression which gradually decreases during differentiation.

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PMC11806182

B Boxplots showing the top ten significantly changed genes.

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PMC11705630

To elucidate the underlying mechanism of the effect of GLDC on RCC progression, we chose ACHN and Caki-2 with stable knock-downed GLDC and conducted further experiments.

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PMC9429973

G. Garcia-Manero, E. S. Winer, D. J. DeAngelo, S. Tarantolo, D. A. Sallman, J. Dugan, S. Groepper, A. Giagounidis, K. Götze, K. H. Metzeler, C.-C. Li, L. Zhou, E. Martinez, M. Lane, R. von Roemeling, M. Bohme, A. S. Kubasch, A. Verma, U. Platzbecker Luekemia, MD Anderson Cancer Center, Houston; Dana-Faber Cancer Instit...

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PMC10747160

Griffithsin is a small (~12.8 kilodalton), dimeric, red algae-derived lectin that displays inhibitory activity against a wide variety of viruses, ranging from Human Immunodeficiency Virus (Retroviridae family) to Herpes Simplex Virus (Herpesviridae family), Japanese Encephalitis Virus (Flaviviridae family), Human Papil...

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PMC9429973

The most common non-SCD-related treatment-emergent AEs were diarrhea, headache, and rash; 37.0% (n=80) of patients reported ≥1 non-SCD-related AE, and most AEs were mild in severity.

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PMC10978090

After surgery, anti-PF4/H IgG increased until D23 (1.01 OD) and became negative again at D29 (0.29 OD).

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PMC11295144

However, the surface or total expression of NL2 showed no difference between these conditions, indicating that other molecular mechanisms may mediate the observed cooperative interaction between NL2 and GABAARs.

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PMC10988808

Overexpression of CCDC25 inhibited the expression of downstream Hippo pathway proteins ITGA3 and CCND1 and promoted YAP phosphorylation.

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PMC8193046

In our previous study, we have explored different ligand-based approaches to validate C@PA .

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PMC9429973

Results: In total, 40 patients with RRMM were enrolled into the study: median age – 64 years (range, 33–80), 35% males.

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PMC9429973

Aims: This phase 1 dose escalation part (NCT04836507) was to evaluate the safety (DLT, MTD), PK and preliminary efficacy (objective response rate and duration of response) in patients with r/r LBCL.

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PMC11802855

Additionally, single-cell RNA sequencing of MM patient samples revealed a strong co-expression of CXCL7 and JAK/STAT3 in the mm03 subgroup (Fig. 2K).

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PMC11635087

The black arrow indicates a CHO cell with chloroplasts. (

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PMC11742047

Apoptosis signaling, in contrast to autophagy and necrosis, is triggered either by death receptors (extrinsic pathway) or by mitochondria (intrinsic pathway), where lipids play a pivotal role in both pathways.

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PMC10890307

MCF-7 cells, a breast tumor cell line that can consume lactate, and non-transformed fibroblast cells (MRC-5) were included as controls.

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PMC11737091

The tumor volume was calculated using the following formula: length × width2/2.

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PMC11604830

Typical examples are represented by (super)paramagnetic, , fluorine‐containing, or hyperpolarized probes for MRI/magnetic particle imaging (MRI/MPI) detection, chromophores/fluorophores for photoacoustic/fluorescence imaging, and radioisotopes for PET/single photon emission computed tomography (PET/SPECT) detection.

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PMC11721277

The reaction mixture was stirred for 1 h at 120 °C in a sealed flask.

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PMC9429973

Summary/Conclusion: Study recruiting in Q2 2022 in US.

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PMC11314247

HDACis have attracted the attention of oncology researchers, and more than 500 clinical trials have recently been initiated.

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PMC9429973

Aims: This abstract will present the preliminary safety and efficacy results from Part B of the SGN35-027 study, which enrolled pts with Ann Arbor Stage II cHL with bulky mediastinal disease (defined as a single node or nodal mass ≥10 cm as determined by CT imaging), or Stage III or IV cHL.

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PMC11342785

The correlation we observed between condensate formation and MT bundling across native and synthetic TPPP variants suggests that regulatable condensation could provide a mechanism for controlling synMAP MT bundling activity in cellular contexts.

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PMC9429973

In higher risk groups, the goal is to prolong survival.

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PMC11201989

Ciliary vesicle formation and protein trafficking are important steps in the hierarchy of cilia assembly.

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PMC10877303

The Canonical SMILES (simplified molecular-input line-entry system) for the screened plausible antiviral phytochemicals were retrieved from the PubChem database.

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PMC9429973

No difference in terms of HIPK2 expression was appreciated in the two groups, suggesting downregulation at post-transcriptional level.

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PMC10926885

RT‐PCR primer sequences.

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PMC11743414

Notably, as a tumor-suppressor gene on the X chromosome, FHL1 may be completely inactivated by a single gene or epigenetic abnormality on an active allele, which is inactivated by DNA methylation and has a high risk of being affected by environment [25–27].

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PMC11786767

C: RO-3306 treatment disrupts mitotic progression.

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PMC6835428

While the approach is, in principle, interesting, it was not determined whether KSP can be considered an appropriate target in OC treatment.

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PMC9985266

ERK and p38 have also been shown to be involved in autophagy .

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PMC8864075

D,E) The inhibitions of siTWIST1 and reTFAE on wound healing (n = 3). (

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PMC8193813

The times to reach 95% of the reference concentration, t95, were 6.3 and 32.3s (relative standard deviation: RSD 8.2% and 11.8%), respectively, for the NO-D4 and NO2-D4 sensors.

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PMC9429973

Amongst mutated pts, the presence of single versus multiple KIT or RAS mutation did not affect optimal PCR responses.

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PMC11127909

In our study, we found that EFHD1 can inhibit mPTP opening by fixing ANT3 in the m-state, promote mitochondrial functions and prevent cell death in a toxic environment, which contributes to promoting OS proliferation and drug resistance (Fig. 7).Fig.

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PMC11615743

Similarly, the cells were incubated with the D‒DNA version of the logic device components.

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PMC9581083

Wu Youke’s Plague Theory and Dai Tianzhang’s Guang Plague Theory proposed that “Jing Fangbaidu San” is a useful formula for those who want to sweat and cool down.

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PMC8753818

This host cell is the cellular factory of about one third of all biopharmaceutical products approved by FDA since 1982 .

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PMC11012012

A flow cytometry analysis of Shlapatska et al. (2001) revealed that all studied B lymphoblastoid cell lines (CESS, MP-1, T5-1, 6.16, and RPMI-1788) and cell lines from patients with XLP (IARC 739, XLP-D, XLP-8002, and XLP-8005), expressed high levels of SLAMF1/CD150.

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PMC9429973

In our phase 1 study in normal healthy volunteers, BLU-263 was safe, with linear pharmacokinetics across all tested doses and a half-life allowing once-daily dosing, and thus supporting continued development for patients with SM.

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PMC10523483

Histones are involved in regulating antioxidant factors that contributes to cell homeostasis and tumor progression (15, 16).

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PMC11718109

While both VMAT1 and VMAT2 are known to localize to secretory vesicles like DCVs in neuroendocrine cells, it is generally believed that dopamine-containing vesicles in neurons are morphologically identical to the VGLUT- and VGAT-containing SV counterparts: clear vesicle clusters with a vesicular diameter of about 40 nm...

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PMC4270159

72 hr after treatment, fix cells in 4% paraformaldehyde (PFA).

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PMC11228511

After 48 h, cells (with or without Dox) were fixed with 4% paraformaldehyde in PBS for 10 min at room temperature and permeabilized with 0.3% Triton X-100 in PBS for 10 min.

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PMC11537649

Lnc NEAT1 overexpression is reported in many solid tumors closely correlated with a poor prognosis.

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PMC10243817

We found that MEX3B preferentially bound to the 3′ UTR of TGFBR3 mRNA in HNECs (Figure 3B).

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PMC10940855

Importantly, gRNA-EFNB2 multiple myeloma cells demonstrated markedly decreased sensitivity to chemotherapy agents, bortezomib and dexamethasone (Fig. 4H).

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PMC11655536

In this study, we observed increased LMP in the HA-treated MM cells.

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PMC4360730

Treatments have been annotated to ChEBI (e.g. 20-hydroxyecdysone—CHEBI:16587 and estradiol—CHEBI:23965).

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PMC11087055

Strikingly, in the aphidicolin-treated embryos (n=4), the polonaise movements initiated but were maintained for a shorter period, 2.2±1.2 hr (control 6.5±1.2 hr, p=0.0038, Figure G-G’”, I-I’”, and Video 2).

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PMC11519788

Wild-type luciferase reporter containing this evolutionarily conserved region (-122 to +705 bp; Figure S4J), and four mutated reporters (with mutations on each VEZF1 binding site) were constructed (Figure 7K).

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PMC9000591

In particular, C. speciosa was reported as rich in saponins, flavonoids, phenolic glycosides, polysaccharides, and formononetin, which revealed numerous biological benefits for humans .

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PMC5716223

CS citrate synthase, GAPDH Glyceraldehyde-phosphate-dehydrogenase, NGF nerve growth factor, αBcry αB-crystallin, JNK c-Jun N-terminal kinases, NFκB nuclear factor kappa-light-chain-enhancer of activated B cells, p75 neurotrophin receptor p75 As summarized in Fig. 3e, our results demonstrate that p75 is sufficient to me...

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PMC9424261

F Reciprocal IP experiments for detecting GSS, MDM2 and SYVN1 in Bel-7402 and Bel-7404 cells which HERPUD1 were overexpressed.

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PMC10847511

P values were corrected for multiple testing using the Holm method.

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PMC8427838

MTs are cytoskeletal filaments composed of heterodimers of α- and β-tubulin subunits and are critically important for chromosomal segregation, intracellular transport, cell division, cell motility and cell morphogenesis .

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PMC11544122

The negatively charged phosphates along the CT of CXCR4 may interact with a positively charged surface or surfaces on SNX9.

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PMC11790971

Scikit-learn (version 0.23.2) was used to implement the ML model and calculate evaluation metrics.

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PMC8097906

The images of invaded cells were taken the bright field microscope (CKX53, Olympus, Tokyo, Japan) and cells were counted with the software CellSens Entry (Olympus, Tokyo, Japan).

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PMC9429973

DARPins were injected intravenously three times per week for two weeks.

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PMC11481779

The example shows chr1:29 500 000–31 500 000 from mouse predicted by the human model Results of applying the human model to the mouse data.

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PMC11469524

Unique and razor peptides were included for quantification.

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PMC11737091

Targeting a specific cell cycle protein seems to be an effective anticancer strategy .

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PMC11470999

Streptavidin–biotin pull‐down and immunoblot assays analyses further showed that PF‐Biotin could simultaneously capture both CIP2A and VHL (Figure 6F), indicating the formation of a PF‒CIP2A‒VHL ternary complex.

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PMC10723784

Ac‐DEVD‐AMC serves as the fluorogenic indicator for assaying caspase‐3/7 activity.

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PMC11486946

The scheme in Fig. 6b, which was suggested from the five non-EGFR-TKI compounds, is effective for removing pathogenic cells that excessively express EGFR, a common phenotype of various cancers, by inducing cell death following EGFR internalization.

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