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OTAR3088
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BioData-CellLine_annotated

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PMC8164677
MTT (3-(4, 5-dimethylthiazole-2yl)-2, 5-diphenyl tetrazolium bromide) assay was performed after 24 hof incubation.
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PMC9429973
Moreover, mononuclear cells were isolated from bone marrow of lymphoma patients, used as controls, and from AML patients at diagnosis who subsequently received chemotherapy with the 7 + 3 regiment.
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PMC10530622
Glyoxylate has several direct precursors, including glycolate and the amino acids glycine, serine and hydroxyproline.
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PMC4485648
This results in diminished promoter activation, transcription and protein levels of the HIF-1 transcriptional target CA IX.
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PMC6337547
The biosynthetic pathway of phenolic acids in Salvia species is shown in Figure 1.
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PMC11348300
The experimental approach for calibrating the PpIX ratiometric signal involved subjecting a cohort of 10 mice to deoxygenation-reoxygenation sequences by inducing oxygen scarcity through excess CO2 breathing (approximately 10 L/min through a nose cone).
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PMC7987994
The relatively high affinity and abundant protein albumin in FBS probably bound a significant portion of the released zinc and thus caused a decrease in toxicity.
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PMC11665555
Upon gemcitabine treatment, these pathways were more significantly enriched in the resistant cells, including ketone body metabolism (Supplemental Figure 3A and Supplemental Table 3).
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PMC10631132
Fibroblast-derived iPSCs also gave off more hematopoietic cells than PBMC-derived iPSCs.
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PMC11171319
Senescence favors transformation and tumor growth through the generation of a senescence-associated secretory phenotype (SASP) with the release of cytokines, chemokines and proteases , and transitory and reversible senescent cell states whereby senescent cancer cells can escape senescence and resume cell proliferation ...
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PMC11777207
We mutated Y56 on murine PD-L1 to alanine and D122 to serine to abolish cis PD-L1 binding with either CD80 or PD-1, respectively, and deleted the cytoplasmic tail of PD-L1 at residue 275 to abolish CD80:PD-L1 intracellular interactions visualized in Fig. 5A (Fig. 5, C to E) (5).
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PMC10809689
Gal-9 can be as free form or cell surface ligand on T cells, dendritic cells, and endothelial cells or other cells in the tumor microenvironment.
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PMC10048572
In two more clones, LOH was detected in two markers, aberrant clones did not match, and in 22 clones, LOH was found in only one STR locus.
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PMC10329237
IPF is a complicated and lethal lung disease that occurs due to collagen decomposition in alveolar cell walls (26).
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PMC9429973
Here, we report further long-term safety, tolerability, and effectiveness of BCX9930.
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PMC10170482
It becomes evident that 3D culturing results in the alteration of metabolic activity and signaling cascades in cancer cells.
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PMC11635519
Data were used to calculate the EC50 value by fitting it to a nonlinear sigmoidal curve using GraphPad Prism 8.
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PMC11585994
Particle size analysis was performed using DLS (Figure 1D), while zeta potential measurements (Figure 1E) revealed a transition from the positive charge of G5 to a negative charge following the successful formation of G5-sgc8-siBCL11B.
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PMC10344560
Our case demonstrated a R glutinis-related PD peritonitis that was successfully managed with voriconazole and catheter removal.
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PMC9429973
Methods: All patients provided informed consent.
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PMC8992508
The synergistic inhibitions observed for compound 7 when combined with a low concentration of chromone 3 (MBL-II-141) suggested that the two inhibitors may bind to distinct sites within BCRP.
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PMC9621239
This study elucidates the compartmentalized evolution patterns of HBV X gene between intra tumour and non-tumour tissues in HCC patients and provides a new mechanism underlying HBV-driven hepatocarcinogenesis, suggesting a potential viral marker for monitoring HCC.Hepatitis B virus (HBV) infection is a major global hea...
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PMC11588085
The assay is based on the proprieties of SCs to efflux dye due to their high expression of ABC transporters.
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PMC4485648
Data were collected every 15 min during the entire period of measurement and were presented as a dimensionless parameter called the cell index (CI; calculated as a relative change in the measured electrical impedance), graphs show the average of triplicate wells.
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PMC11487720
UV rapidly decreased the expression of α-tubulin, whereas cold shock had no effect (Fig. 5E).
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PMC9895440
To knock out genes using Cas9-crRNA-tracrRNA ribonuclear protein complexes, the Lonza Nucleofector 4D system was used.
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PMC11680562
The primary mechanism behind the anti-cancer properties of CuO NPs is their capacity to induce the production of reactive oxygen species (ROS) inside HeLa cells, resulting in oxidative stress.
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PMC9351137
Five classes of defects were categorized.
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PMC11748335
= not significant) in (A and G).
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PMC11588085
XIST expression in 430 ovarian tumors (TCGA cohort) compared to 195 normal ovaries (GTEx database). (
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PMC11143482
As shown in Fig. 6, mice injected with 1 × 10 of cancer cells not capable of producing tumour compared to mice injected with 3 × 10 cancer cells.
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PMC10142392
Studies have shown that polymeric vesicles are more robust, with a critical surface deformation before rupture ten times greater than that of lipid vesicles .
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PMC11283030
Understanding the mechanism of lipid metabolic reprogramming will facilitate the development of novel targeted therapeutic strategies for ccRCC.
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PMC9429973
F. Bamigbola, L. Warwick, N. Bolaños Research; Management, Lymphoma Coalition, Mississauga, Canada Background: Lymphomas are a mixed group of cancers that have a variety of clinical presentations ranging from an indolent course to an aggressive disease.
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PMC11078693
CRITICAL: Cover the flask with aluminum foil to block light exposure.
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PMC7039683
In zebrafish embryos the periderm (initially called the enveloping layer [EVL]) becomes a distinct lineage at about 4 hr post fertilization (hpf), shortly before gastrulation, and is derived from superficial blastomeres that do not express tp63 (Kimmel et al., 1990).
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PMC11720808
Scale bar, 50 μm. (
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PMC11574271
Bladder cancer cells were fixed in 4% (w/v) paraformaldehyde, washed with PBS, and then permeabilized with 0.1% Triton X-100 as previously described .
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PMC8270637
T lymphocytes are an important part of the HCC microenvironment, and programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) are the main immunosuppressive molecules of T lymphocytes.
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PMC11697189
D-E) ORSC2 and A498 cells viability was assessed using CCK8 assay; (F-G) Expression of E-cadherin, Vimentin and N‐cadherin in A498 cells were evaluated by Western blot; (H-I) Scratch healing assay of A498 were cells with different treatments. (
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PMC10940855
Viable cells were counted by Trypan blue exclusion on the indicated incubation time points and cell growth cure was plotted.
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PMC11499381
With the exception of C-terminal fusion of V1–154 to CLR, complementary overhang sequences were also introduced in this PCR step.
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PMC11791203
These phytochemicals from the chloroform extract were docked onto Cox-2, Bax, caspase 3, and caspase 9, proteins associated with the mitochondrial apoptotic pathway.
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PMC2196094
The RBL-1 cells expressed RMCP-2, -8, and low levels of RMCP-1, -3, and -4, but no RMCP-5 (Fig. 9 B).
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PMC11535726
Both Kirschsteiniotheliabulbosapicalis and K.longirostrata exhibit distinct characteristics from other species of Kirschsteiniothelia.
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PMC7215722
Evans Blue (EB) solution (Sigma - E2129) was prepared in 1% BSA (bovine serum albumin, cell culture grade; Grand Island Biological Company, New Zealand, Cat# 11020-021) at a concentration of 170 μg/mL then filtered through 0.22-μm filters (Corning).
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PMC11206502
To determine if HB-induced autophagy is statistically significant compared to untreated samples and starvation-induced autophagy, a Chi square test was applied (PAST 3.15).
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PMC9429973
There was a decrease in the SPM with acalabrutinib as compared to the control group (pooled RR 0.67; 95%CI 0.46-0.96; P= 0.03) (Figure).
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PMC11495567
Mean fluorescence intensities per cell against the respective concentrations were plotted. (
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PMC11026382
As in earlier plots, green indicates negative epistasis, and pink indicates positive epistasis.
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PMC8633974
All the control and treatment groups were assessed independently of each other.
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PMC5673060
Fragmented ions were scanned in the FT-Orbitrap at 60,000 resolution (selected first mass at 100 m/z) with a target AGC value of 50,000 and a maximum injection time of 100 ms.
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PMC9429973
Leukemic blasts were identified using the CD45/SSC gating procedure.
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PMC11013014
In the present work, the synthesis of new ethacrynic acid (EA) derivatives containing nitrogen heterocyclic, urea, or thiourea moieties via efficient and practical synthetic procedures was reported.
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PMC10604092
Moreover, NGAL acts on erythroid progenitor cells and negatively regulates erythrocyte differentiation and production during hematopoiesis .
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PMC11806818
The advantages and limitations of these sensors are summarized, along with their potential in clinical diagnosis and personalized medicine.
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PMC11699465
For (F), cell1 is HCT116 cells, cell2 is 143B cells; For (G), it is done in 4T1 cells; (H) is done in CaoV-3 cells.(I) Western blotting assay shows the PD-L1 protein level when TMEM199 was compensated to cells with TMEM199 knockdown.(J and K) QPCR shows the CD274 mRNA level when IFNGR1 (J) or Trim28 (K) was depressed (...
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PMC9429973
M. Sasaki, K. Suzuki, Y. Abe, S. Ito, K. Nishiwaki, H. Handa, T. Chou, J. Soeda, I. Mori, T. Shinozaki, N. Takezako Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine; Division of Hematology, Myeloma and AL Amyloidosis Center, Japanese Red Cross Medical Center; Division of H...
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PMC9429973
Further, second-line SOC treatment is often associated with poor health-related quality of life (Lin V, et al. J Clin Oncol.
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PMC11742047
For multivariate statistical analysis, UV scaling and log10 transformation were applied.
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PMC9927933
We next investigated possible underlying mechanisms by which UBE2C knockdown suppressed growth and survival of lung cancer cells.
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PMC9429973
Until now, FLT3-ITD MRD detection by RQ-PCR has been hampered by the variety in patient specific FLT3-ITD (i.e. sequence, position and length) and is currently not recommended because of potential instability of FLT3-ITD clones during relapse.
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PMC11750712
The mechanism for the absence of CAR T expansion and TRBC1 depletion is not fully understood.
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PMC9429973
Ten patients presented with del(17p) and twelve patients with t(4;14).
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PMC9429973
Results: Out of 799 untreated MDS pts, 147 pts (32%) developed HMA-F with a median follow-up time of 44.0 months (mo) from diagnosis.
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PMC6468656
The number of cycles corresponding to plateau was determined and PCR was performed at exponential range.
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PMC9118379
SAVControl, in contrast, adopts mass shift relocation to assess the reliability of the variant site, where the mass shift, defined as the variant peptide precursor mass minus the wild-type peptide mass, is relocalized on each position of the wild-type peptide sequence to confirm that the mass shift localizing at the va...
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PMC11757230
For differences between multiple groups, normally distributed data were analyzed with one-way analysis of variance and compared using Dunnett's test or the Tukey–Kramer multiple comparison post hoc test.
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PMC11765988
Establishing a definitive diagnosis of sarcoidosis-lymphoma syndrome through clinical and radiological findings is challenging, and an optimal diagnostic approach has yet to be determined.
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PMC9429973
The RX/WT-expressing cells had an intermediate phenotype (43%).
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PMC10887351
In human myocardial tissue, the lack of β3-AR sites for GPCR kinases, which causes the absence of desensitization or downregulation signaling, revealed that in the failing myocardium, the β3-AR levels did not change but were increased, maintaining, thus, their intracellular signaling .
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PMC6461034
Instead, several substrate‐centric approaches, focusing on phosphopeptides derived from kinase targets, also exist, including KSEA (Casado et al, 2013; Terfve et al, 2015; Wilkes et al, 2015), pCHIPS (Drake et al, 2016), and IKAP (Mischnik et al, 2016).
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PMC11190538
During 28 days of storage, Izadi et al. found a fall-rise pattern in yoghurt pH (P > 0.05).
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PMC9429973
Induction of hepcidin synthesis via Nrf2 activation is a novel therapeutic approach, and these results support further clinical development of IMR-261 as a treatment for conditions associated with iron dysregulation, including hereditary hemochromatosis.
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PMC11531735
All analyses were performed using R Statistical Software, p value was 0.048.
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PMC10092581
The Au(I) complexes’ overall behavior does explain their better solubility compared to the Ag(I) analogues when dissolution was initially attempted in 80 : 20 D2O/DMSO‐d6 solution, since the hydrated form, [Au(H2O)]Cl, is expected to be more water soluble.
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PMC11754432
Qupath was used to generate ROIs for the epidermis to measure intensity and subcellular detection for the number of RNAscope spots.
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PMC11585587
The results showed that expression levels of pro-apoptotic proteins, such as Cleaved PARP and Cleaved Caspase 3/9, were significantly increased in MM.1 S and RPMI 8226 cells (Fig. 3 C, D and G, H).
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PMC11045125
Several different EBV genes/RNAs expressed in human BLs with Wp-restricted and/or type I latency may inhibit Myc-induced apoptosis by complementary mechanisms.
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PMC10440586
Kaplan-Meier curves of the Schalper dataset; patient groups were divided by pre-treatment CD99 expression level. (
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PMC10114490
On the other hand, the hepatoma cell line HepG2 is robust, cheap and easy to handle but performs a limited number of hepatocyte functions (reviewed in ) and display features of neoplastic transformation.
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PMC9429973
Median (interquartile range [IQR]) age of the 87 pts was 33 (25–40) years, 57% were female, 45% were African American, 8% Caucasian, 20% Hispanic and 28% of ‘other’ ethnicity, and 82% had an HbSS genotype.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9341513
Whereas all of the genes show an increase, that of CCND1 is by far the largest: more than 500-fold.
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PMC11657744
In contrast, reduced expression of Cep83, Sclt1, and Cep164 markedly decreased cilia frequency compared to controls (Fig. 2A).
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PMC9429973
Prospective studies are needed to elucidate whether doxycycline improves outcomes in AL amyloidosis and identify the optimal dose, duration, timing, and the subset of patients likely to benefit.
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PMC11023271
LPA functions by inhibiting the transcription of RIPK4 mRNA.
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PMC11723947
To test whether HP1α inhibition could potentially block or reverse this process, we finally compared the transcriptomic signature induced by HP1α-deficiency in allospecific murine CD4 T cells to those of intratumoral human Teff and Tex.
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PMC11758416
Figure 1Depiction of cytotoxic T cells (red) and L cells (green) during the described cytotoxicity assay Depiction of cytotoxic T cells (red) and L cells (green) during the described cytotoxicity assay The data exemplified in this protocol focus on total or memory CD8 T cells isolated from blood of healthy donors.
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PMC11244823
The protocol for the LIPS assay was adapted from Springer Protocols from “Immuno proteomics–methods and protocols” .
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PMC11143482
Statistical analysis showed that food intake in mice injected with 3 × 10 HOS-143B cells (44.33 ± 2.08) was significantly lower than that in the mice inoculated with 1 × 10 cells (48.67 ± 1.53) and control groups (55.67 ± 1.15), P < 0.05 on Day 20.
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PMC11765988
This also applies to HLA-DRB1*11 and HLA-DRB1*12 and Epstein-Barr virus-associated lymphoma .
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PMC11802855
However, subcutaneous soft tissue metastatic foci were identified in the mice of the OE group, but not in those of the NC group.
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PMC9268620
Nevertheless, healthy, unaffected cells could still be observed in this culture.
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PMC11001582
n = 3 independent biological replicates, one-way ANOVA, Bonferroni’s multiple comparison.
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PMC11593713
Elevated ROS levels in the early stages of viral infections adversely affect the cells and tissues and are important for antiviral immune function .
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PMC8592717
PAL mediated polo-like kinase 2 (PLK2) expression, which upregulated glycogen synthase kinase 3 β (GSK3β) phosphorylation and Nrf2 nuclear translocation, improved mitochondrial dysfunction, and attenuated oxidative stress injury, which resulted in effective neuroprotection .
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PMC5363531
A similar pattern alteration was observed with the combination of dasatinib and PEM, along with the expected inhibition of SRC phosphorylation secondary to dasatinib.
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PMC6114978
Occasional mutations have been identified in the scaffolding proteins MOB1A/B .
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PMC10994876
The current study demonstrated a notable upregulation in the transcription of the c-MYC gene, a proto-oncogene responsible for encoding a transcription factor (Jaluria et al. 2007).
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PMC9429973
Per RUCA categories, 8.9% and 91.1% of patients were residents of rural and urban areas, respectively.
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