OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC6160470	Cell cycle (d) and apoptosis (e) assessment: A2780/Adr cells were cultured without treatment (CTRL), treated with compounds alone as indicated (0.1 µM paclitaxel, PTX; 10 µM verapamil, Ver; 1 µM DAC-2Amide and -3Amide), or in combination with paclitaxel as indicated for 48 h (SubG1 – cell with less than 2n DNA content;...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patients who participated in clinical trials at any line were excluded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "who", "participated", "in", "clinical", "trials", "at", "any", "line", "w...
PMC9429973	Each patient received a regimen based on the John Hopkins protocol [Leffel, 2013], comprising a single dose of rituximab 375mg/kg, four alternate day cycles of single volume plasmapheresis [replacing 100% volume with 5% albumin] and anti-CMV hyperimmune immunoglobulin 100mg/kg on days -16, -14, -12 and -10 before the i...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257203	Statistical analyses were performed using GraphPad Prism statistical software (version 6, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analyses", "were", "performed", "using", "GraphPad...
PMC11530949	A noteworthy decrease in cell viability at concentrations as low as 6.25 µg/mL for NPs compared to higher concentrations required for the plant extract indicates the potent anticancer impact of the synthesized NPs even at low concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	Inhibition curves were fitted with a nonlinear least-squares fit with variable slope using the following function:[12pt] $$}=+()/(1+(}}}_/X})^}}}}-}}}}}})$$=min+(max−min)/1+(IC50/X)Hill−slopewhere min and max are the minimal and maximal response, and IC50 is the half-maximal inhibitory concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604015	No tumor contamination was observed during CAR-T product manufacturing in this study .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "tumor", "contamination", "was", "observed", "during", "CAR-T", "product", ...
PMC10178190	In all cases, significant RJY13 chemoresistance was conferred.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "all", "cases", ",", "significant", "RJY13", "chemoresistance", "was", "conferred", "." ] } ]
PMC10850553	The representative images of immunofluorescent staining of IA lesions for C5AR1 (green), C5a/C5a des-arg (red in (A)), C5 (red in (B)), and merged images with nuclear staining by DAPI (blue) are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: To our knowledge this is the first study in LR-MDS patients assessing longitudinally all critical parameters and providing objective measurements of subclinical atherosclerosis in all vascular beds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10607604	The Flp-In OVCAR-8 clones that contain a unique Flp recombination target (FRT) site were obtained using stable transfection of the pFRTLacZeo vector (Invitrogen) and selection with 100 µg/mL zeocin.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11478724	The MTT test was used to measure the cytotoxic effect of PMX on the A549 cells after 24 and 48 h of exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	In addition, the relationship between Drp-1-mediated mitochondrial division and ZnO NPs-induced apoptosis in human leukemia cells was also explored.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", ...
PMC10142392	It is not surprising that the four-arm polymer (PCL1600)3-PEGMA11900 has the smallest hydrodynamic diameter (28 nm) and CMC (2.66 µg mL), likely due to the higher degree of branching of the hydrophobic core, resulting in a more compact core and thus a smaller size (Figure 20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11578343	HMECs were screened for differences in viscoelastic phenotypes across six primary strains: three from average‐risk women (aged 33–40 years) without any known breast cancer‐causing germline mutations, and three from high‐risk women (aged 24–35 years) with BRCA1 germline mutations (Table S3, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11761919	Surface-displayed Fiber2 protein was prepared according to our previous report (Ma et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Surface-displayed", "Fiber2", "protein", "was", "...
PMC11638764	Anti-proliferative activity was measured using a CellTiter Glo® Luminescent Cell Viability Assay (Promega G7572) according to the manufacturer’s procedure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-pr...
PMC11740207	This transition is often associated with cancer metastasis (Sacco and Gomez, 2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "transition", "is", "often", "associated", "with", "...
PMC11706776	Following the primary antibody incubation, sections were washed in 1× TBS Tween pH 7.4 and samples were incubated for 45 min at room temperature using a polyclonal biotinylated donkey anti-rabbit secondary antibody (Jackson ImmunoResearch), and finally with an HRP conjugated streptavidin complex (Agilent) for another 4...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11758416	This is often a result of stress on the target cells (L cells) prior to the cytotoxicity assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "often...
PMC7039683	Such functional SNPs can be identified through systematic reporter assays: functional SNPs will have allele-specific effects on the enhancer activity of the encompassing element, while rider SNPs may not have this quality (Liu et al., 2017a; Lidral et al., 2015).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5839394	Values expressed as µg/ml; values expressed as µM. In order to assess SKBR3 cell viability in terms of reproductive capacity after treatments with the two kinds of AgNPs-EPS, a colony formation assay was performed .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	DIS3depleted cells showed a significant perturbation of cell cycle in all the HMCLs tested.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DIS3depleted", "cells", "showed", "a", "significant", "perturbation", ...
PMC11409031	A–J) PCR was performed to detect the transcript levels of TGOLN2, NBL1, ARID1B, ISG20, KRAS, CLIC3, ALOX5AP, PFN1, DNAJA1, and LASP1 in human normal ovarian epithelial cells, IOSE80, and in human OV cell line, HEY.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11297139	The representative images supported by the relevant statistics have been chosen upon three independent preparations with similar outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "representative", "images", "supported...
PMC11437637	The immune function of patients with EC was significantly lower than that of healthy people (P < 0.05) and those with benign uterine diseases (P < 0.05) and was related to body mass index (BMI), hypertension, diabetes, and blood lipids (P < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Being able to predict the HbF level of an individual is complex as the number of QTLs is large.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Being", "able", "to", "predict", ...
PMC9429973	We tested ALS20a in CD34 cells isolated from four patients with both deletional and non-deletional HbH disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "tested", "ALS20a", "in", "CD34", "cel...
PMC9429973	We show that downstream of OMA1 the apoptotic stress signal is relayed to HRI by DELE1, whereas OMA1-dependent OPA1 cleavage and mitochondrial fragmentation were dispensable for the therapeutic effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10938336	Swiss Target Prediction, on the other hand, utilized the SMILES notations of selected compounds to identify potential targets based on a reverse pharmacophore matching approach.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740573	In recent years, there has been an increase in studies showing that low concentration of vitamin D is also linked to a higher risk of infections with both bacterial and viral origins [2–5].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11451940	The product was filtered with cold H2O (3 × 10 mL), cold MeOH (2 × 10 mL) and Et2O (3 × 10 mL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740573	Currently, we can find only one report assessing the relationship of vitamin D with the occurrence and course of AV .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", ",", ...
PMC11759543	For time-dependent cytotoxic analysis, it was observed that doxorubicin time- and dose-dependently reduced cell viability in 5637 and BFTC 905 cells (Fig. 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O"...
PMC11222184	p < 0.05, p < 0.01, p < 0.001, and ***p < 0.0001, ns not significant) Changes in the expression of heat shock proteins (Hsp27, HSP70, HSP90) in SH-SY-5Y cells after a 48 h treatment with XL-888 and Debio0932.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8922418	For example, Zhang et al. demonstrated that the dCas9-SAM system could efficiently target the HIV-1 LTR promoter in TZM-b1, J-LAT, 2D10, 3C9, E4, and CHME5 microglial cells (Saayman et al., 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O"...
PMC10582049	In addition, the analysis of genes associated with different signaling pathways showed that the FAPACTA2 cluster was characterized by increased activity of TGFβ pathway (Fig. 3D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11534035	Our findings support the notion that SERPINE1/PAI1 expression levels are influenced by GPER1 activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "support", "the", "notion", "that", "SERPINE1/PAI1",...
PMC11802929	See color key inset.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "See", "color", "key", "inset", "." ] } ]
PMC9429973	In maintenance (28-day cycles), pts received R (10 mg PO D1-21; if tolerated, 15 mg in Cycles 10+) ± DARA (16 mg/kg IV Q8W/Q4W or 1800 mg SC per protocol amendments).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9119314	The recent introduction of the nitroheterocyclic compound fexinidazole as an oral treatment for both stage 1 and stage 2 infections has been a major step forward (Pelfrene et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519583	a Proliferation of MPs, treated with respective siRNAs in the absence or presence of Wnt5b (200 ng/ml), was evaluated using WST-8 assay at the indicated time points (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11045125	Interestingly, although high level expression of unphosphorylated STAT3 decreases induction of lytic EBV infection in Burkitt cells in vitro , we found here that the Myc-expressing tumors have a lower level of EBV lytic gene expression (S2C Fig) despite their decreased STAT3 levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746948	The cell viability of the compound alone treatment group was used to exclude the toxicity of the compound library to the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell"...
PMC10582049	Projection of samples isolated from LUAD patients within stromal cell populations (middle).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Projection", "of", "samples", "isolated", "from", "LUAD", "patients", ...
PMC10607604	The term ovarian carcinoma defines a heterogeneous group of epithelial tumors with different subtypes, pathophysiology, prognosis, and response to treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11476222	The protein concentration of each cell line was determined using a micro-BCA protein assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "concentration", "of", "each", "cell", "line", ...
PMC11592837	In ETP-treated PBMCs, cytotoxicity increased after 4–6 h and was more profound after 8 h of incubation, whereas with DOX, the level of pan-stained nuclei was comparable or even lower than in control cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11200978	CA is known to be immunomodulatory as a monotherapy , and NSCLC has been shown to respond to immune activation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CA", "is", "known", "t...
PMC9429973	Student’s t-test or Mann-Whitney U-test were used for comparison of means.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Student", "’s", "t-test", "or", "Mann-Whitney", "U-test", "were", "used", "for",...
PMC11680982	P < 0.05; P < 0.01; *P < 0.001; n = 5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", ";", ...
PMC11656657	The evaluation of CAR T-cell memory profile reveals a rapid decline in naïve compartment in both CAR.GD2 and NT T-cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "evaluation", "of", ...
PMC11711127	Approved regimens for treatment of autoimmune conditions often fail to induce long-lasting remission and given their broad specificity can carry a wealth of side effects that increase susceptibility to opportunistic infections and even cancers (174).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540611	Cells were seeded at 2 × 10 cells/mL in 500 µL suitable culture medium on 24-well plates (1 × 10 cells/well) and preincubated for 24 h before treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11546117	The setup was controlled by μManager (version 1.4.23).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "setup", "was", "controlled", "by", "μManager", "(", "version", "1.4.23", ")", "." ...
PMC9596868	To study the effects of quercetin and MST-312 on telomerase activity, PA-1 cells were seeded at a density of 6×105 cells/well in 6-well culture plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629192	No tumor was detected.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "No", "tumor", "was", "detected", "." ] } ]
PMC11638255	Drug repurposing is becoming an increasingly attractive approach to reduce the time, resources, and risks associated with de novo drug research and development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10578720	A comprehensive description of all methods is provided in the Supplemental Methods section, http://links.lww.com/HC9/A582.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "comprehensive", "description", "of", "all", "methods", ...
PMC9429973	Demographic data, clinical manifestations, associated comorbidities and thrombotic complications were collected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Demographic", "data", ",", "clinical", "manifestations", ",", "associated", ...
PMC6222726	It belongs to the simaruba group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "belongs", "to", "the", "simaruba", "group", "." ] } ]
PMC5673060	The online tool Venny 2.1 (http://bioinfogp.cnb.csic.es/tools/venny/) was used to generate Venn diagrams and GraphPad Prism 7.02 was used to generate the pie charts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11352746	In addition, while using the fluorescent microscopy component of this system, we encountered several issues running our neurite outgrowth studies with primary rat cortical neurons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640419	Given its intricate and multifaceted mechanisms, it exerts a favorable impact on lipid metabolism in individuals with diabetes mellitus and metabolic syndrome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given",...
PMC7229095	2ClonePix2 images comparing colonies from a CDM1/CloneMatrix mixtures, b CDM2/CloneMatrix mixtures, and c CDM3/CloneMatrix mixturesTable 5Summary of ClonePix2 cloning resultsConditionsCDM1CDM2CDM3Too small (excluded colonies too small)38226483728Proximity (excluded colonies too close to each other)23454768156Pickable c...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	The localized mouse xenograft model was described previously (32).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "localized", "mouse", "xenograft", "model", "was", "described", "previously", "(", ...
PMC11720107	To date, only a few studies have indicated that aged garlic extract, alliin (a garlic organosulfur compound), or garlic-derived diallyl disulfide may affect PPARγ molecular pathways in different cell culture models .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3734024	Immunoblotting for FasL confirmed this result, as IL-5-stimulated B cells had readily-detectable FasL protein whereas FasL was not detectable in an equivalent number of freshly-isolated CD19 B cells (Figure 5G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11298021	U6: Housekeeping non-coding RNA, ACTB (β-actin): housekeeping gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "U6", ":", "Housekeeping", "non-coding", "RNA", ",", "ACTB", "(", "β-actin", ...
PMC10654497	Top 15 frequently mutated genes in patients with (A) subtypes C1 and (B) subtypes C2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Top", "15", "frequently", "mutate...
PMC11188874	Eluted peptides were lyophilized and reconstituted in 0.1% TFA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eluted", "peptides", "were", "lyophilized", "and", "reconstituted", "in", "0.1", "%", "TFA", ...
PMC10907726	These findings indicated that DATS inhibited cell growth, migration, invasion and EMT in OS.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "indicated", "that", "DATS", "inhi...
PMC11319300	No H3K27ac peaks were observed in 25 tissues, a group that includes brain tissues/primary cells, ovary and testis (Supplementary Table S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8567602	This corroborates literature that retracted the briefly held concept in the synovial sarcoma field that SS18–SSX's only oncogenic function was ejection of SMARCB1 from BAF-family complexes (24, 29–31).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2944824	In vivo, apoptosis as detected by positive TUNEL labeling and caspase 3 activity was lower in wild-type mice compared to Hr knockouts after exposure to trimethyltin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10810426	The eluted nucleic acid was purified using the DNeasy Kit (Qiagen) and analyzed by qPCR with strong-stop primers (primers PR and PU5) or by RT-qPCR with the PR primer and a primer that anneals to nucleotides 39 to 57 in tRNAPro (PtRNA) (13).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11687663	A. Aisyah et al., reported cytotoxic effect of methanolic fraction of Angiopteris ferox against pulmonary HTB cell line with an IC50 grade of 78.96 μg/mL .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371747	Concentration-dependent inhibition of the RFC-mediated influx of 5 µM [H]-l-leucovorin in CEM 7A cells (with 30-fold overexpression of RFC compared to wild type CCRF-CEM cells) by LV-stereoisomers, PLX and MTX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine"...
PMC11087055	Apoptotic index in control and aphidicolin-treated embryos (control 10.6±3.5% vs aphidicolin 12.1 ± 3.7%, p=0.20, n=4 for each). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11343332	After being sterilized, confluent cells were passaged.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "being", "sterilized", ",", "confluent", "cells", "were", "passaged", "." ] } ]
PMC11026382	FPLC fractions containing TYMS were combined and concentrated using a 10 kDa Amicon concentrator (Millipore) and stored at 4 °C for up to a week.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10748106	A molecular similarity analysis of three groups was performed: (1) Genipin with other simple iridoids, (2) Genipin with Geniposide, and (3) designed iridoids with one of the most cytotoxic iridoids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802929	For the SCT Expression row, darker red lines correspond to higher SCT expression, while gray means low/no expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "SCT", "E...
PMC11740573	These data show that vitamin D sufficiency obtained by cells prior to infection prevents inflammatory gene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "show", "that", "vitamin", ...
PMC11607321	For each of the seven datasets (views), an encoder is trained with multiple fully connected layers, which are all proportional to the number of input features of the dataset plus the number of labels (concatenated conditionals).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11397654	More recently, this multivalent platform has also been employed to prepare potential anticancer drugs, as proved by the publication of numerous articles which have been in part reviewed .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637284	TAC40 and ATOM40 serve as positive and negative controls, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TAC40", "and", "ATOM40", "serve", "as", "positive", "and", "negative", "controls", ",...
PMC10178190	Therefore, we also explored HGF’s involvement in platinum chemoresistance mediated by TA HS-5-derived CM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Therefore", ",", "we", "also", "explored", "H...
PMC11585587	Then, Western blot was used to detect the expression of apoptosis-related proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "Western", "blot", "was", "used", "to", "detect", "the", ...
PMC9429973	Before transplantation, 49 patients (70.0%) had intervening anticancer regimen; 34 (48.6%) had active disease, 31 patients (44.3%) were in remission at time of transplant, and 5 patients (7.1%) had unknown disease status.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Among 131 (63%) pts with a known MYD88 status, 88% (n=116) had MYD88 genotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "131", "(...
PMC11629192	A poor treatment response was defined as no improvement on the mRS or mRS score ≥4 for 4 weeks .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "poor", "treatment", "respons...
PMC9429973	der(1;7) cases had frequent mutations affecting RUNX1 (37.8%), EZH2 (18.9%) and ETNK1 (18.2%), which were less common in -7/del(7q) cases (OR=5.58, OR=6.52, and OR=6.23, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604830	Time = 11 min 12 s), while NA = 128 for the reference tubes (acq.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Time", "=", "11", "min", "12", "...
PMC11489175	Natural compounds or their derivatives may also display capability to interfere with DUBs as proved for the degradation product of curcumin, caffeic acid phenethyl ester that has been reported to inhibit USP8 132.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772449	We combined pirfenidone with Sora to explore its inhibitory effect on hepatocellular carcinoma, and explored the synergistic anticancer mechanism of pirfenidone, in order to solve the drug resistance problem in the practical clinical application of Sora, and to further optimize the treatment plan for patients with adva...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11277157	In this study, we investigated the role of KD in DJ-1 in the cellular context of HEK293 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "In", "this", "study", ",...
PMC11345828	The resultant compound was alkylated with MeI following General Procedure D (1.43 g, 85% yield), LCMS Method 2: RT = 1.979, 2.025 min, MS (ESI): m/z 888.2 (M + H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674146	The function of PI3K/AKT signaling pathway caught our attention, and the correlation between CLP36 and PI3K/AKT/CREB was determined firstly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "function", "of", ...
PMC9872547	This protein was detected by mouse GAPDH primary antibody (1: 1000, Abcam Company) and antimouse HRC conjugated secondary antibody (1: 1000) (from Santa Cruz).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6160470

Cell cycle (d) and apoptosis (e) assessment: A2780/Adr cells were cultured without treatment (CTRL), treated with compounds alone as indicated (0.1 µM paclitaxel, PTX; 10 µM verapamil, Ver; 1 µM DAC-2Amide and -3Amide), or in combination with paclitaxel as indicated for 48 h (SubG1 – cell with less than 2n DNA content;...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Patients who participated in clinical trials at any line were excluded.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "who", "participated", "in", "clinical", "trials", "at", "any", "line", "w...

PMC9429973

Each patient received a regimen based on the John Hopkins protocol [Leffel, 2013], comprising a single dose of rituximab 375mg/kg, four alternate day cycles of single volume plasmapheresis [replacing 100% volume with 5% albumin] and anti-CMV hyperimmune immunoglobulin 100mg/kg on days -16, -14, -12 and -10 before the i...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11257203

Statistical analyses were performed using GraphPad Prism statistical software (version 6, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analyses", "were", "performed", "using", "GraphPad...

PMC11530949

A noteworthy decrease in cell viability at concentrations as low as 6.25 µg/mL for NPs compared to higher concentrations required for the plant extract indicates the potent anticancer impact of the synthesized NPs even at low concentrations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11806106

Inhibition curves were fitted with a nonlinear least-squares fit with variable slope using the following function:[12pt] $$}=+()/(1+(}}}_/X})^}}}}-}}}}}})$$=min+(max−min)/1+(IC50/X)Hill−slopewhere min and max are the minimal and maximal response, and IC50 is the half-maximal inhibitory concentration.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11604015

No tumor contamination was observed during CAR-T product manufacturing in this study .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "tumor", "contamination", "was", "observed", "during", "CAR-T", "product", ...

PMC10178190

In all cases, significant RJY13 chemoresistance was conferred.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "all", "cases", ",", "significant", "RJY13", "chemoresistance", "was", "conferred", "." ] } ]

PMC10850553

The representative images of immunofluorescent staining of IA lesions for C5AR1 (green), C5a/C5a des-arg (red in (A)), C5 (red in (B)), and merged images with nuclear staining by DAPI (blue) are shown.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Image: Summary/Conclusion: To our knowledge this is the first study in LR-MDS patients assessing longitudinally all critical parameters and providing objective measurements of subclinical atherosclerosis in all vascular beds.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10607604

The Flp-In OVCAR-8 clones that contain a unique Flp recombination target (FRT) site were obtained using stable transfection of the pFRTLacZeo vector (Invitrogen) and selection with 100 µg/mL zeocin.

[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11478724

The MTT test was used to measure the cytotoxic effect of PMX on the A549 cells after 24 and 48 h of exposure.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

In addition, the relationship between Drp-1-mediated mitochondrial division and ZnO NPs-induced apoptosis in human leukemia cells was also explored.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", ...

PMC10142392

It is not surprising that the four-arm polymer (PCL1600)3-PEGMA11900 has the smallest hydrodynamic diameter (28 nm) and CMC (2.66 µg mL), likely due to the higher degree of branching of the hydrophobic core, resulting in a more compact core and thus a smaller size (Figure 20).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11578343

HMECs were screened for differences in viscoelastic phenotypes across six primary strains: three from average‐risk women (aged 33–40 years) without any known breast cancer‐causing germline mutations, and three from high‐risk women (aged 24–35 years) with BRCA1 germline mutations (Table S3, Supporting Information).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11761919

Surface-displayed Fiber2 protein was prepared according to our previous report (Ma et al., 2017).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Surface-displayed", "Fiber2", "protein", "was", "...

PMC11638764

Anti-proliferative activity was measured using a CellTiter Glo® Luminescent Cell Viability Assay (Promega G7572) according to the manufacturer’s procedure.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-pr...

PMC11740207

This transition is often associated with cancer metastasis (Sacco and Gomez, 2024).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "transition", "is", "often", "associated", "with", "...

PMC11706776

Following the primary antibody incubation, sections were washed in 1× TBS Tween pH 7.4 and samples were incubated for 45 min at room temperature using a polyclonal biotinylated donkey anti-rabbit secondary antibody (Jackson ImmunoResearch), and finally with an HRP conjugated streptavidin complex (Agilent) for another 4...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11758416

This is often a result of stress on the target cells (L cells) prior to the cytotoxicity assay.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "often...

PMC7039683

Such functional SNPs can be identified through systematic reporter assays: functional SNPs will have allele-specific effects on the enhancer activity of the encompassing element, while rider SNPs may not have this quality (Liu et al., 2017a; Lidral et al., 2015).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5839394

Values expressed as µg/ml; values expressed as µM. In order to assess SKBR3 cell viability in terms of reproductive capacity after treatments with the two kinds of AgNPs-EPS, a colony formation assay was performed .

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PMC9429973

DIS3depleted cells showed a significant perturbation of cell cycle in all the HMCLs tested.

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PMC11409031

A–J) PCR was performed to detect the transcript levels of TGOLN2, NBL1, ARID1B, ISG20, KRAS, CLIC3, ALOX5AP, PFN1, DNAJA1, and LASP1 in human normal ovarian epithelial cells, IOSE80, and in human OV cell line, HEY.

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PMC11297139

The representative images supported by the relevant statistics have been chosen upon three independent preparations with similar outcomes.

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PMC11437637

The immune function of patients with EC was significantly lower than that of healthy people (P < 0.05) and those with benign uterine diseases (P < 0.05) and was related to body mass index (BMI), hypertension, diabetes, and blood lipids (P < 0.05).

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PMC9429973

Being able to predict the HbF level of an individual is complex as the number of QTLs is large.

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PMC9429973

We tested ALS20a in CD34 cells isolated from four patients with both deletional and non-deletional HbH disease.

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PMC9429973

We show that downstream of OMA1 the apoptotic stress signal is relayed to HRI by DELE1, whereas OMA1-dependent OPA1 cleavage and mitochondrial fragmentation were dispensable for the therapeutic effect.

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PMC10938336

Swiss Target Prediction, on the other hand, utilized the SMILES notations of selected compounds to identify potential targets based on a reverse pharmacophore matching approach.

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PMC11740573

In recent years, there has been an increase in studies showing that low concentration of vitamin D is also linked to a higher risk of infections with both bacterial and viral origins [2–5].

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PMC11451940

The product was filtered with cold H2O (3 × 10 mL), cold MeOH (2 × 10 mL) and Et2O (3 × 10 mL).

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PMC11740573

Currently, we can find only one report assessing the relationship of vitamin D with the occurrence and course of AV .

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PMC11759543

For time-dependent cytotoxic analysis, it was observed that doxorubicin time- and dose-dependently reduced cell viability in 5637 and BFTC 905 cells (Fig. 1C).

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PMC11222184

p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001, ns not significant) Changes in the expression of heat shock proteins (Hsp27, HSP70, HSP90) in SH-SY-5Y cells after a 48 h treatment with XL-888 and Debio0932.

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PMC8922418

For example, Zhang et al. demonstrated that the dCas9-SAM system could efficiently target the HIV-1 LTR promoter in TZM-b1, J-LAT, 2D10, 3C9, E4, and CHME5 microglial cells (Saayman et al., 2016).

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PMC10582049

In addition, the analysis of genes associated with different signaling pathways showed that the FAPACTA2 cluster was characterized by increased activity of TGFβ pathway (Fig. 3D).

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PMC11534035

Our findings support the notion that SERPINE1/PAI1 expression levels are influenced by GPER1 activation.

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PMC11802929

See color key inset.

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PMC9429973

In maintenance (28-day cycles), pts received R (10 mg PO D1-21; if tolerated, 15 mg in Cycles 10+) ± DARA (16 mg/kg IV Q8W/Q4W or 1800 mg SC per protocol amendments).

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PMC9119314

The recent introduction of the nitroheterocyclic compound fexinidazole as an oral treatment for both stage 1 and stage 2 infections has been a major step forward (Pelfrene et al., 2019).

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PMC11519583

a Proliferation of MPs, treated with respective siRNAs in the absence or presence of Wnt5b (200 ng/ml), was evaluated using WST-8 assay at the indicated time points (n = 3).

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PMC11045125

Interestingly, although high level expression of unphosphorylated STAT3 decreases induction of lytic EBV infection in Burkitt cells in vitro , we found here that the Myc-expressing tumors have a lower level of EBV lytic gene expression (S2C Fig) despite their decreased STAT3 levels.

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PMC11746948

The cell viability of the compound alone treatment group was used to exclude the toxicity of the compound library to the cells.

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PMC10582049

Projection of samples isolated from LUAD patients within stromal cell populations (middle).

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PMC10607604

The term ovarian carcinoma defines a heterogeneous group of epithelial tumors with different subtypes, pathophysiology, prognosis, and response to treatment.

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PMC11476222

The protein concentration of each cell line was determined using a micro-BCA protein assay.

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PMC11592837

In ETP-treated PBMCs, cytotoxicity increased after 4–6 h and was more profound after 8 h of incubation, whereas with DOX, the level of pan-stained nuclei was comparable or even lower than in control cells.

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PMC11200978

CA is known to be immunomodulatory as a monotherapy , and NSCLC has been shown to respond to immune activation .

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PMC9429973

Student’s t-test or Mann-Whitney U-test were used for comparison of means.

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PMC11680982

P < 0.05; **P < 0.01; ***P < 0.001; n = 5.

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PMC11656657

The evaluation of CAR T-cell memory profile reveals a rapid decline in naïve compartment in both CAR.GD2 and NT T-cells.

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PMC11711127

Approved regimens for treatment of autoimmune conditions often fail to induce long-lasting remission and given their broad specificity can carry a wealth of side effects that increase susceptibility to opportunistic infections and even cancers (174).

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PMC8540611

Cells were seeded at 2 × 10 cells/mL in 500 µL suitable culture medium on 24-well plates (1 × 10 cells/well) and preincubated for 24 h before treatment.

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PMC11546117

The setup was controlled by μManager (version 1.4.23).

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PMC9596868

To study the effects of quercetin and MST-312 on telomerase activity, PA-1 cells were seeded at a density of 6×105 cells/well in 6-well culture plates.

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PMC11629192

No tumor was detected.

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PMC11638255

Drug repurposing is becoming an increasingly attractive approach to reduce the time, resources, and risks associated with de novo drug research and development.

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PMC10578720

A comprehensive description of all methods is provided in the Supplemental Methods section, http://links.lww.com/HC9/A582.

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PMC9429973

Demographic data, clinical manifestations, associated comorbidities and thrombotic complications were collected.

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PMC6222726

It belongs to the simaruba group.

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PMC5673060

The online tool Venny 2.1 (http://bioinfogp.cnb.csic.es/tools/venny/) was used to generate Venn diagrams and GraphPad Prism 7.02 was used to generate the pie charts.

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PMC11352746

In addition, while using the fluorescent microscopy component of this system, we encountered several issues running our neurite outgrowth studies with primary rat cortical neurons.

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PMC11640419

Given its intricate and multifaceted mechanisms, it exerts a favorable impact on lipid metabolism in individuals with diabetes mellitus and metabolic syndrome.

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PMC7229095

2ClonePix2 images comparing colonies from a CDM1/CloneMatrix mixtures, b CDM2/CloneMatrix mixtures, and c CDM3/CloneMatrix mixturesTable 5Summary of ClonePix2 cloning resultsConditionsCDM1CDM2CDM3Too small (excluded colonies too small)38226483728Proximity (excluded colonies too close to each other)23454768156Pickable c...

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PMC9878562

The localized mouse xenograft model was described previously (32).

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PMC11720107

To date, only a few studies have indicated that aged garlic extract, alliin (a garlic organosulfur compound), or garlic-derived diallyl disulfide may affect PPARγ molecular pathways in different cell culture models .

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PMC3734024

Immunoblotting for FasL confirmed this result, as IL-5-stimulated B cells had readily-detectable FasL protein whereas FasL was not detectable in an equivalent number of freshly-isolated CD19 B cells (Figure 5G).

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PMC11298021

U6: Housekeeping non-coding RNA, ACTB (β-actin): housekeeping gene.

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PMC10654497

Top 15 frequently mutated genes in patients with (A) subtypes C1 and (B) subtypes C2.

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PMC11188874

Eluted peptides were lyophilized and reconstituted in 0.1% TFA.

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PMC10907726

These findings indicated that DATS inhibited cell growth, migration, invasion and EMT in OS.Fig.

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PMC11319300

No H3K27ac peaks were observed in 25 tissues, a group that includes brain tissues/primary cells, ovary and testis (Supplementary Table S2).

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PMC8567602

This corroborates literature that retracted the briefly held concept in the synovial sarcoma field that SS18–SSX's only oncogenic function was ejection of SMARCB1 from BAF-family complexes (24, 29–31).

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PMC2944824

In vivo, apoptosis as detected by positive TUNEL labeling and caspase 3 activity was lower in wild-type mice compared to Hr knockouts after exposure to trimethyltin.

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PMC10810426

The eluted nucleic acid was purified using the DNeasy Kit (Qiagen) and analyzed by qPCR with strong-stop primers (primers PR and PU5) or by RT-qPCR with the PR primer and a primer that anneals to nucleotides 39 to 57 in tRNAPro (PtRNA) (13).

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PMC11687663

A. Aisyah et al., reported cytotoxic effect of methanolic fraction of Angiopteris ferox against pulmonary HTB cell line with an IC50 grade of 78.96 μg/mL .

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PMC11371747

Concentration-dependent inhibition of the RFC-mediated influx of 5 µM [H]-l-leucovorin in CEM 7A cells (with 30-fold overexpression of RFC compared to wild type CCRF-CEM cells) by LV-stereoisomers, PLX and MTX.

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PMC11087055

Apoptotic index in control and aphidicolin-treated embryos (control 10.6±3.5% vs aphidicolin 12.1 ± 3.7%, p=0.20, n=4 for each). (

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PMC11343332

After being sterilized, confluent cells were passaged.

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PMC11026382

FPLC fractions containing TYMS were combined and concentrated using a 10 kDa Amicon concentrator (Millipore) and stored at 4 °C for up to a week.

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PMC10748106

A molecular similarity analysis of three groups was performed: (1) Genipin with other simple iridoids, (2) Genipin with Geniposide, and (3) designed iridoids with one of the most cytotoxic iridoids.

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PMC11802929

For the SCT Expression row, darker red lines correspond to higher SCT expression, while gray means low/no expression.

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PMC11740573

These data show that vitamin D sufficiency obtained by cells prior to infection prevents inflammatory gene expression.

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PMC11607321

For each of the seven datasets (views), an encoder is trained with multiple fully connected layers, which are all proportional to the number of input features of the dataset plus the number of labels (concatenated conditionals).

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PMC11397654

More recently, this multivalent platform has also been employed to prepare potential anticancer drugs, as proved by the publication of numerous articles which have been in part reviewed .

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PMC11637284

TAC40 and ATOM40 serve as positive and negative controls, respectively.

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PMC10178190

Therefore, we also explored HGF’s involvement in platinum chemoresistance mediated by TA HS-5-derived CM.

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PMC11585587

Then, Western blot was used to detect the expression of apoptosis-related proteins.

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PMC9429973

Before transplantation, 49 patients (70.0%) had intervening anticancer regimen; 34 (48.6%) had active disease, 31 patients (44.3%) were in remission at time of transplant, and 5 patients (7.1%) had unknown disease status.

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PMC9429973

Among 131 (63%) pts with a known MYD88 status, 88% (n=116) had MYD88 genotype.

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PMC11629192

A poor treatment response was defined as no improvement on the mRS or mRS score ≥4 for 4 weeks .

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PMC9429973

der(1;7) cases had frequent mutations affecting RUNX1 (37.8%), EZH2 (18.9%) and ETNK1 (18.2%), which were less common in -7/del(7q) cases (OR=5.58, OR=6.52, and OR=6.23, respectively).

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PMC11604830

Time = 11 min 12 s), while NA = 128 for the reference tubes (acq.

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PMC11489175

Natural compounds or their derivatives may also display capability to interfere with DUBs as proved for the degradation product of curcumin, caffeic acid phenethyl ester that has been reported to inhibit USP8 132.

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PMC11772449

We combined pirfenidone with Sora to explore its inhibitory effect on hepatocellular carcinoma, and explored the synergistic anticancer mechanism of pirfenidone, in order to solve the drug resistance problem in the practical clinical application of Sora, and to further optimize the treatment plan for patients with adva...

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PMC11277157

In this study, we investigated the role of KD in DJ-1 in the cellular context of HEK293 cells.

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PMC11345828

The resultant compound was alkylated with MeI following General Procedure D (1.43 g, 85% yield), LCMS Method 2: RT = 1.979, 2.025 min, MS (ESI): m/z 888.2 (M + H).

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PMC11674146

The function of PI3K/AKT signaling pathway caught our attention, and the correlation between CLP36 and PI3K/AKT/CREB was determined firstly.

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PMC9872547

This protein was detected by mouse GAPDH primary antibody (1: 1000, Abcam Company) and antimouse HRC conjugated secondary antibody (1: 1000) (from Santa Cruz).

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