OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11411004	HDAC, histone deacetylase, mRNA; siHDAC5, small interfering RNA of HDAC5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HDAC", ",", "histone", "deacetylase", ",", "mRNA", ";", "siHDAC5...
PMC11186948	We found significant differences in acetylation pattern among the three groups, assessed with one-way ANOVA (p < 0.01) (Fig. 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11634794	Therefore, LAMP1 emerges as a novel biomarker associated with the diagnosis and prognosis of renal cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "LAMP1", "emerges", "as", ...
PMC8389560	For the first time, the role of Cx43 in the regulation of apoptosis caused by selenium nanoparticles in glioblastoma cells has been shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Thumb anomalies were found exclusively in patients with RPL5 mutations; cleft lip and palate were reported only in patients with RPS10 and RPL11 mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	We quantified the abundance of differentially expressed (DE) genes (P adj<0.05) in the sensitive or resistant cell line by RNA-seq and identified enriched pathways in the insensitive SI cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10840195	All experiments were repeated in triplicate in three independent experiments. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "repeated", "in", "triplicate", "in", "three", "independent", ...
PMC8357004	Thus, abnormal variations of these enzymes can contribute to tumorigenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "abnormal", "variations", "of", "these", "enzymes", "can", "contribute", ...
PMC11618052	The quinazoline derivatives (3a–e) were then alkylated with propargyl bromide (4) in the presence of anhydrous K2CO3 by stirring in DMF, yielding S-propargyl derivatives (5a–e) in 70–83% yields that were purified by ethanol recrystallization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763764	The KRCH31 cell line was derived from a patient who was diagnosed with high-grade serous ovarian tumor and developed resistance to platinum–paclitaxel combination therapy .	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543885	Active interaction sources, including text mining, experiments, and databases, and an interaction score > 0.7 (high confidence interaction) are applied to construct the PPI networks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4685407	We constructed a CRISPR-Cas9 vector that expresses a guide RNA sequence targeting a region on chromosome O. Chromosome O was selected based on a previous classification of gene-amplified CHO cell chromosomes in order of decreasing size and assigned letters from A to T by fluorescence in situ hybridization (FISH) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6364197	A similar trend of combination use of Ara-C and DNR was obtained in TCPS (24.67±4.73%) and UPS cultures (39±7.55%) in comparison to 80 µg/ml CTCPS (46.33±4.04%) for 168 h (Fig. 5C; **P<0.01 vs. TCPS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6181431	Previous studies have identified MTOR mutations capable of preventing each of rapalog and ATP-competitive kinase inhibition of mTOR kinase activity in vivo and in vitro .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7925574	A correct version of the original Figure 1e.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "correct", "version", "of", "the", "original", "Figure", "1e", "." ] } ]
PMC7039683	A customized Python script was used to identify fragments shorter than 100 bp as the nucleosome-free-regions (NFRs), as previously described (custom scripts and piplines we deployed are available at https://github.com/Badgerliu/periderm_ATACSeq; copy archived at https://github.com/elifesciences-publications/periderm_AT...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11590005	The independent variables comprised participants’ gen-der, self-declared skin colour, age, current semester of the dentistry course, occupation, national region of the dental school of enrolment, school admin-istrative type and family monthly income.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11779993	The total flavonoid content of SPEE was examined using the aluminum chloride colorimetric method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "total", "flavonoid", "content", "of", "SPEE", "was", "exa...
PMC11357960	Moreover, the analysis of combined three genes (cut-off value, AUC, sensitivity and specificity of 5.5, 0.791, 57.7% and 96.2%, respectively) yielded a higher diagnostic accuracy than that of single gene in NR diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718109	The dysfunction of dopaminergic (DA) neurons is central to Parkinson’s disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dysfunction", "of", "dopaminergic", "(", "DA", ")", "neur...
PMC10055960	In this regard, the increased potency demonstrated by complex 5 in the OVCAR-3 cell line is encouraging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "regard", ",", "the", ...
PMC11049548	A2780cis cells show very high levels of phosphocholine (PC, log2(FC) = 4.49) and glycerophosphocholine (GPC, log2(FC) = 2.44) with respect to A2780 cells.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074	As instructed, a 1× wash buffer was made by diluting 10× wash buffer with distilled water, and SAM was diluted with DNMT assay buffer at a 4:1 ratio.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11733919	GFP-Lamp1 signals (protein levels) are presented in relative fluorescence units (RFU).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GFP-Lamp1", "signals", "(", "protein", "levels", ")", "are"...
PMC11098378	Cells were transfected with either an empty vector or a luciferase-encoding pDGOpIE2 plasmid for 48 h and then subsequently transfected with siRNAs targeting transcripts encoding LacZ or luciferase (S5A Fig).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461874	Nuclear proteins were isolated as previously described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nuclear", "proteins", "were", "isolated", "as", "previously", "described", "." ] } ]
PMC6835428	Multidrug resistance gene 1 (MDR1) is a membrane-bound P-glycoprotein overexpressed in chemo-resistant OC cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multidrug", "resistance", "gene", "1", "(", "MDR1", ...
PMC11049294	The generated GLA KO cell line carries a 36 base pair deletion in the 1st exon of the GLA gene: seq[GRCh38] NC_000023.11(NM_000169):g.101,407,776_ 101,407,812del (Figure 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9031474	Kitte and Tretbar et al. obtained the sesquiterpenoids polygodial (2), warburganal (24), and muzigadial (26) from the stem bark of Warburgia ugandensis and tested their cytotoxic activity against leukemia (MV4-11 and THP-1), melanoma (Sk-Mel29), and glioblastoma (LN-229) cell lines (Figure 7) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11247842	The QTL region on BTA14 overlaps the well-known QTL candidate for milk yield and composition, DGAT1, which has also been reported to be associated with mastitis resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Approximately a third of pts with newly diagnosed AML harbor mutations in the fms-like tyrosine kinase 3 (FLT3) gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", "a", ...
PMC11794588	Worms and extracts were combined, and then a 96-well microplate was put into a WMicroTracker (Phylumtech, Argentina) device and incubated for 24 h at 20 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591794	The main regulators of the intrinsic pathway are the Bcl-2 family pro and anti-death members .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "main", "regulators", "of", "the", "intrinsic", "path...
PMC11380329	The response rate to first-line therapy is around 80–90%, but most patients relapse and develop chemotherapy resistance and the 5-year survival rate is < 30% .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9727330	Our findings provide evidence for the potential anticancer properties of NNDAsp with minimal cytotoxic outcomes in normal cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "provide", "evidence", ...
PMC11763111	Initially, we employed the Hu-SRC-SCID model, which was generated via transplantation of CD34 hematopoietic stem cells from the umbilical cord blood into immunodeficient mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10812665	On d3 cells display an established neurite network (positive for beta-III tubulin) and they express vesicular monoamine transporter-2 (VMAT) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", ...
PMC3675084	BPR0L075 displayed similar sensitivity in all paired parental and paclitaxel-resistant ovarian cell lines with IC50 values ranging from 2–7 nM (Figure 1B). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11361748	Freshly isolated neutrophils (0.4 million cells in 100 μl of 1× mHBSS) were added into the upper chamber (insert) and 600 μl of CM or control medium (0.1% FBS) into the lower chamber (well of the plate).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11387401	Assay C and D were performed on uninfected and NL4.3 HIV-1 infected SupT1 cells, respectively, with anti-FLAG antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Assay", "C", ...
PMC11291697	Experiments were performed at least in triplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experiments", "were", "performed", "at", "least", "in", "triplicate", "." ] } ]
PMC11683240	An inhibiting effect of α1AT against PT-intoxication of cells was observed at concentrations starting from around 30 μM α1AT, falling within the concentration ranges found in healthy individuals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3734024	As IL-5 is associated with the type-2 immune response, we hypothesized that IL-4, the hallmark cytokine of the type-2 response, might have an enhancing effect on the IL-5-mediated killer B cell program.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240448	We used a 20% Occam’s window in BMRA sampling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "a", "20", "%", "Occam", "’s", "window", "in", "BMRA", "sampling",...
PMC11306331	This domain is highly similar amongst the three family members, consisting of over 50% glycine, glutamine, serine, and tyrosine residues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9275501	Two strategies for NDCDS of natural active ingredients and chemotherapy drugs: physical encapsulation and carrier-linked prodrug delivery system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "strategies", "for", "NDCDS...
PMC11711127	Extensive alteration of cellular morphology and metabolism is connected with the prompt exit from quiescence, which occurs before activation-induced proliferation (39).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8662250	Cells were treated with SARS‐CoV‐2 SP dissolved in ultrapure and pyrogen‐free sterile vehicle for 24 h. SP concentrations were previously selected by pilot experiment aimed at identifying the lowest effective concentration (data not shown).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379	Transcription data of the 38 previously identified differentially expressed genes from 47 adherent and 16 suspension cell lines (Supplementary Table S9) was compared between the two groups using a Mann–Whitney U-test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10671321	Since muscle cells produce endogenous AChE, we did not co-infect these cells with Ache AAV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "muscle", "cells", "produce", "endogenous", "A...
PMC11545868	Prunetin 4′-O-glucoside, also known as 4′-O-beta-D-glucoside and prunetrin, is a glycosyloxyisoflavone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prunetin", "4′-O-glucoside", ",", "also", "known", "as", "4′-O-beta-D-glucoside",...
PMC8557138	For example, both transcriptional and translational upregulation of VEGF-A and vascular endothelial growth factor receptor-2 (VEGFR2) in diabetic vasculopathy, such as proliferative retinopathy, results in excessive angiogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Constitutional changes in RNA expression levels and altered metabolism due to ERCC6L2 deficiency may also affect the bone marrow niche and help us understand the disease more profoundly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11271278	As illustrated in Fig. 4A, the high copy number of ecDNAs, along with increased chromatin accessibility, results in the overexpression of oncogenes such as EGFR in glioblastoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461025	Given the evidence that isoginkgetin exhibits anti-cancer properties, we were interested in examining its effects on a mammalian melanoma (A375) cancer cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine"...
PMC11277157	Testing the induction of RULC vs. naïve, non-treated cells shows the upregulated set of coding transcripts (total of 75 genes, marked interferon stimulation, Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8956657	For example, mutations within both the minor site (Arg24Ala), and the major site (Arg33Ala and Arg37Ala) resulted in the MERS-CoV ORF4b binding using a canonical Lys P2 involving TKKLR, with Lys binding at the P2 site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11545868	Additionally in the study of Hua, F., et al., daidzein has been shown to have anticancer effects on ovarian cancer through mitochondrial-mediated apoptosis, cell cycle arrest, and inhibition of the Raf/MEK/ERK pathway (Table 1) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5925824	NCI-H292, HCC827, and A204 cells were stained for PD-L1 using FITC-conjugated anti-human PD-L1 commercial antibody (clone MIH1, BD Biosciences), Alexa Fluor® 488-conjugated LY3300054, or appropriate isotype controls.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11680982	Therefore, it is necessary to further validate the findings of this study in the clinic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "it", "is", "necessary", "to", ...
PMC11791264	In summary, we have identified a methylation-dependent regulatory mechanism controlling LC3B’s role in autophagy for the first time, and the methylation of LC3B can inhibit autophagosome formation and promote cancer cell phenotypes in OC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615218	In patients with CLL, Fraietta et al. found that those achieving CR received lower percentages of anti-CD19 CAR-T cells expressing PD-1 combined with either TIM3 or LAG3, compared with patients achieving partial or no response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Furthermore, phosphorylation of phospho-SMAD2/3 was found to be significantly lower in post-ATG (2052 ± 428, mean fluorescence intensity, n=4) compared to pre-ATG (3323 ± 32; p=0.03) treated cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: CPX-351 was administered to 74 patients as first induction chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "CPX-351", "was", "administered", "to", "74", "patients", "as", ...
PMC11422497	These non-coding RNAs feature a covalently closed loop structure, making them resistant to exonucleases and providing stability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "non-coding", "RNAs", "feature", ...
PMC8584319	The anti-phospho 4E-BP1 (Ser65), anti-4E-BP1, anti-phospho ERK 1/2, anti-ERK 1/2, anti-phospho p38, anti-p38, anti-phospho-JNK, anti-JNK, anti-phospho eIF2α, anti-eIF2α, anti-phospho c-Jun, anti-c-Jun, and horseradish peroxidase-conjugated secondary antibodies were obtained from Cell Signaling Technology (Danvers, MA, ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9611901	Therefore, we chose the HepG2 cell model for this pilot study, which is considered useful for investigating the genotoxicity of compounds with unknown or poorly known mechanisms of action .	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11348300	On the day of the initial use, mice were anesthetized, and ALA was either injected i.p.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "day", "of", "the", ...
PMC11607638	The RNAi and SK peptide injection experiments revealed that SK and SKR are important to regulate blood meal intake and satiety in A. aegypti (Figures 2 and 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Comparison between groups was performed by Mann Whitney test for continuous variables and Chi-Square test for Categorical variables.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Comparison", "between", "groups", "was", ...
PMC9646302	In gliomas, high RAC1 expression promotes tumor migration and invasion by inducing epithelial-mesenchymal transition and increasing matrix metalloproteinase expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "gliomas", ",", "...
PMC11661024	Fig. 3Flow cytometer graphs are presented for assessing apoptosis provoked by postbiotic derivate from Lactobacilli sp. at 24 h in A control cell, B IC50 concentration of postbiotic derivate from L. fermentum CH.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11701801	Therefore, we examined the potential for expansion/adaptation of CBP/p300 dual inhibitors to cancers carrying abnormal SWI/SNF constituent genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "examined"...
PMC10957991	To assess how TRPV4 is expressed in the normal mammary epithelium and whether it is found in the contractile mammary epithelial basal layer, we utilized immunohistochemical, IHC, stainings of the mammary gland tissue slices as well as two normal human mammary epithelial cell lines, MCF10A and 184A1, containing a mixtur...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3730428	In cells in which procaspase 8 was depleted, the apoptosis induced by SAHA and AT-IAP/TNFα cotreatment was completely abrogated (Figure 7d), indicating that the mechanism of cell death is caspase eight-dependent, consistent with a FLIP-dependent mechanism (Figure 7b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10079526	Viability dose response curves were plotted individually per cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Viability", "dose", "response", "curves", "were", "plotted", "individually", "per", "cell", "lin...
PMC11411131	Krabx2-Sec is a tandem repeat of Krab fused with TetR and Sec and was predicted to intensify trans-repression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Krabx2-Sec", "is", "a", "tandem", "rep...
PMC11741577	As shown in Fig 2D, in HaCaT cell migration assays, the wound closure rate was highest when HMC-1 cells were treated with the TLR2/6 agonist FSL-1 for 24 hours, compared to other TLR agonists.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "...
PMC8740518	Therefore, we speculate that cancer can lower cholesterol levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "speculate", "that", "cancer", "can", "lower", "cholesterol", "levels", ...
PMC11638288	The presence of these NKp46LTi cells induces the upregulation of adhesion molecules in tumor vasculature, leading to increased leukocyte infiltration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "presence", ...
PMC11413393	Data are presented as the mean ± SEM and p-values are calculated by 2-way ANOVA with repeated measures and Sidak’s multiple comparisons test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC4270159	p-AKT S473.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "p-AKT", "S473", "." ] } ]
PMC11703896	Rapamycin binds with FKBP12 (FK505 Binding protein) and the resulting complex binds to the mTORC1 through the FRB domain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rapamycin", "binds", ...
PMC9895440	c Representative flow cytometry plots and quantification of SNX9 expression measured by antibody staining in flow cytometry of human CD8 T cells of the ex vivo model with the different conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11643491	No significant difference in cytotoxic effect was observed between A375+ and A375− cells treated with spherical drug-loaded particles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "significant", "differenc...
PMC8097906	The quantification revealed significant actin-stabilizing properties of VSM10 and VSM25 shown by a significant 1.7- to 2.6-fold increase respectively in filament length and filament number.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11488203	Alternatively, MSC-derived EVs/exosomes can also be used as a vehicle for the transport of therapeutic compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alternatively", ",", "MSC-derived", "EVs/exosomes", ...
PMC11337594	TER treatment of A375 cells for 24 h, identified by KEGG (gene set enrichment analysis) typical pathway analysis of RNA-seq data.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC10823017	An agarose conjugated PKC−ι antibody was used to pull down PKC-ι from the cell lysates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "agarose", "conjugated", "PKC−ι", "antibody", "was", "...
PMC11604830	R corresponds to the right PLN, L to the left PLN, G to a standard reference tube containing pure low‐gelling agar, P to a standard reference tube containing PFCE‐NE in low‐gelling agar (proton concentration 0.66 M), W to a water containing tube.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591052	Beyond metabolic enzymes, we also studied the expression of c-Myc and ATF3 as two important transcriptional regulators of glycolysis, one-carbon metabolism, and respiration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11721277	Electronic absorption spectra were obtained using a Shimadzu UV-1800 spectrophotometer (Shimadzu Corporation, Kyoto, Japan) in a 10 mm thick quartz cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6222726	This compound was shown to be active against LNCaP (androgen-sensitive human prostate adenocarcinoma) cell line (ED50 1.1 μg/mL) during tests aimed at developing an in vivo Hollow Fiber Assay .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7685376	This study was approved by the Ethics Committee of Shanghai Municipal Hospital of Traditional Chinese Medicine and conducted in accordance with the Declaration of Helsinki.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC3681794	Untreated controls were exposed to the same concentration ranges of cisplatin, doxorubicin and etoposide in normoxia and hypoxia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Untreated", "controls", "were", "...
PMC6835428	Prolonged peritoneal persistence can present an advantage, as ovarian cancer metastasis typically colonizes the mesothelial cell layer without affecting the basal lamina .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prolong...
PMC9014716	PS-T significantly inhibited the viability of human HepG2 and Bel-7404 cells in a dose-dependent manner at 48 and 72 hours (Figures 1A and B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC8584666	Statistical analyses methods are indicated in each figure legend, and the calculations were performed using the GraphPad Prism software, version 5.03 (San Diego, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878278	We found that exogenous treatment with recombinant TGF-β1 or Activin A at both lower (data not shown) and higher (Figure 5B) concentrations showed no significant change in ZIKV RNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11434983	This effect was reported at 1 μΜ concentration, even lower than the cytotoxicity IC50 concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "effect", "was", "reported", "at", "1", "...

PMC11411004

HDAC, histone deacetylase, mRNA; siHDAC5, small interfering RNA of HDAC5.

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PMC11186948

We found significant differences in acetylation pattern among the three groups, assessed with one-way ANOVA (p < 0.01) (Fig. 5A).

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PMC11634794

Therefore, LAMP1 emerges as a novel biomarker associated with the diagnosis and prognosis of renal cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "LAMP1", "emerges", "as", ...

PMC8389560

For the first time, the role of Cx43 in the regulation of apoptosis caused by selenium nanoparticles in glioblastoma cells has been shown.

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PMC9429973

Thumb anomalies were found exclusively in patients with RPL5 mutations; cleft lip and palate were reported only in patients with RPS10 and RPL11 mutations.

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PMC9429973

We quantified the abundance of differentially expressed (DE) genes (P adj<0.05) in the sensitive or resistant cell line by RNA-seq and identified enriched pathways in the insensitive SI cell line.

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PMC10840195

All experiments were repeated in triplicate in three independent experiments. *

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PMC8357004

Thus, abnormal variations of these enzymes can contribute to tumorigenesis.

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PMC11618052

The quinazoline derivatives (3a–e) were then alkylated with propargyl bromide (4) in the presence of anhydrous K2CO3 by stirring in DMF, yielding S-propargyl derivatives (5a–e) in 70–83% yields that were purified by ethanol recrystallization.

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PMC11763764

The KRCH31 cell line was derived from a patient who was diagnosed with high-grade serous ovarian tumor and developed resistance to platinum–paclitaxel combination therapy .

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PMC11543885

Active interaction sources, including text mining, experiments, and databases, and an interaction score > 0.7 (high confidence interaction) are applied to construct the PPI networks.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4685407

We constructed a CRISPR-Cas9 vector that expresses a guide RNA sequence targeting a region on chromosome O. Chromosome O was selected based on a previous classification of gene-amplified CHO cell chromosomes in order of decreasing size and assigned letters from A to T by fluorescence in situ hybridization (FISH) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6364197

A similar trend of combination use of Ara-C and DNR was obtained in TCPS (24.67±4.73%) and UPS cultures (39±7.55%) in comparison to 80 µg/ml CTCPS (46.33±4.04%) for 168 h (Fig. 5C; **P<0.01 vs. TCPS).

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PMC6181431

Previous studies have identified MTOR mutations capable of preventing each of rapalog and ATP-competitive kinase inhibition of mTOR kinase activity in vivo and in vitro .

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PMC7925574

A correct version of the original Figure 1e.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "correct", "version", "of", "the", "original", "Figure", "1e", "." ] } ]

PMC7039683

A customized Python script was used to identify fragments shorter than 100 bp as the nucleosome-free-regions (NFRs), as previously described (custom scripts and piplines we deployed are available at https://github.com/Badgerliu/periderm_ATACSeq; copy archived at https://github.com/elifesciences-publications/periderm_AT...

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PMC11590005

The independent variables comprised participants’ gen-der, self-declared skin colour, age, current semester of the dentistry course, occupation, national region of the dental school of enrolment, school admin-istrative type and family monthly income.

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PMC11779993

The total flavonoid content of SPEE was examined using the aluminum chloride colorimetric method.

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PMC11357960

Moreover, the analysis of combined three genes (cut-off value, AUC, sensitivity and specificity of 5.5, 0.791, 57.7% and 96.2%, respectively) yielded a higher diagnostic accuracy than that of single gene in NR diagnosis.

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PMC11718109

The dysfunction of dopaminergic (DA) neurons is central to Parkinson’s disease.

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PMC10055960

In this regard, the increased potency demonstrated by complex 5 in the OVCAR-3 cell line is encouraging.

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PMC11049548

A2780cis cells show very high levels of phosphocholine (PC, log2(FC) = 4.49) and glycerophosphocholine (GPC, log2(FC) = 2.44) with respect to A2780 cells.

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PMC11594074

As instructed, a 1× wash buffer was made by diluting 10× wash buffer with distilled water, and SAM was diluted with DNMT assay buffer at a 4:1 ratio.

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PMC11733919

GFP-Lamp1 signals (protein levels) are presented in relative fluorescence units (RFU).

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PMC11098378

Cells were transfected with either an empty vector or a luciferase-encoding pDGOpIE2 plasmid for 48 h and then subsequently transfected with siRNAs targeting transcripts encoding LacZ or luciferase (S5A Fig).

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PMC11461874

Nuclear proteins were isolated as previously described.

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PMC6835428

Multidrug resistance gene 1 (MDR1) is a membrane-bound P-glycoprotein overexpressed in chemo-resistant OC cells .

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PMC11049294

The generated GLA KO cell line carries a 36 base pair deletion in the 1st exon of the GLA gene: seq[GRCh38] NC_000023.11(NM_000169):g.101,407,776_ 101,407,812del (Figure 2B).

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PMC9031474

Kitte and Tretbar et al. obtained the sesquiterpenoids polygodial (2), warburganal (24), and muzigadial (26) from the stem bark of Warburgia ugandensis and tested their cytotoxic activity against leukemia (MV4-11 and THP-1), melanoma (Sk-Mel29), and glioblastoma (LN-229) cell lines (Figure 7) .

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PMC11247842

The QTL region on BTA14 overlaps the well-known QTL candidate for milk yield and composition, DGAT1, which has also been reported to be associated with mastitis resistance .

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PMC9429973

Approximately a third of pts with newly diagnosed AML harbor mutations in the fms-like tyrosine kinase 3 (FLT3) gene.

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PMC11794588

Worms and extracts were combined, and then a 96-well microplate was put into a WMicroTracker (Phylumtech, Argentina) device and incubated for 24 h at 20 °C.

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PMC11591794

The main regulators of the intrinsic pathway are the Bcl-2 family pro and anti-death members .

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PMC11380329

The response rate to first-line therapy is around 80–90%, but most patients relapse and develop chemotherapy resistance and the 5-year survival rate is < 30% .

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PMC9727330

Our findings provide evidence for the potential anticancer properties of NNDAsp with minimal cytotoxic outcomes in normal cells.

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PMC11763111

Initially, we employed the Hu-SRC-SCID model, which was generated via transplantation of CD34 hematopoietic stem cells from the umbilical cord blood into immunodeficient mice.

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PMC10812665

On d3 cells display an established neurite network (positive for beta-III tubulin) and they express vesicular monoamine transporter-2 (VMAT) .

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PMC3675084

BPR0L075 displayed similar sensitivity in all paired parental and paclitaxel-resistant ovarian cell lines with IC50 values ranging from 2–7 nM (Figure 1B). (

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PMC11361748

Freshly isolated neutrophils (0.4 million cells in 100 μl of 1× mHBSS) were added into the upper chamber (insert) and 600 μl of CM or control medium (0.1% FBS) into the lower chamber (well of the plate).

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PMC11387401

Assay C and D were performed on uninfected and NL4.3 HIV-1 infected SupT1 cells, respectively, with anti-FLAG antibody.

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PMC11291697

Experiments were performed at least in triplicate.

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PMC11683240

An inhibiting effect of α1AT against PT-intoxication of cells was observed at concentrations starting from around 30 μM α1AT, falling within the concentration ranges found in healthy individuals.

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PMC3734024

As IL-5 is associated with the type-2 immune response, we hypothesized that IL-4, the hallmark cytokine of the type-2 response, might have an enhancing effect on the IL-5-mediated killer B cell program.

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PMC11240448

We used a 20% Occam’s window in BMRA sampling.

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PMC11306331

This domain is highly similar amongst the three family members, consisting of over 50% glycine, glutamine, serine, and tyrosine residues.

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PMC9275501

Two strategies for NDCDS of natural active ingredients and chemotherapy drugs: physical encapsulation and carrier-linked prodrug delivery system.

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PMC11711127

Extensive alteration of cellular morphology and metabolism is connected with the prompt exit from quiescence, which occurs before activation-induced proliferation (39).

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PMC8662250

Cells were treated with SARS‐CoV‐2 SP dissolved in ultrapure and pyrogen‐free sterile vehicle for 24 h. SP concentrations were previously selected by pilot experiment aimed at identifying the lowest effective concentration (data not shown).

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PMC7642379

Transcription data of the 38 previously identified differentially expressed genes from 47 adherent and 16 suspension cell lines (Supplementary Table S9) was compared between the two groups using a Mann–Whitney U-test.

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PMC10671321

Since muscle cells produce endogenous AChE, we did not co-infect these cells with Ache AAV.

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PMC11545868

Prunetin 4′-O-glucoside, also known as 4′-O-beta-D-glucoside and prunetrin, is a glycosyloxyisoflavone.

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PMC8557138

For example, both transcriptional and translational upregulation of VEGF-A and vascular endothelial growth factor receptor-2 (VEGFR2) in diabetic vasculopathy, such as proliferative retinopathy, results in excessive angiogenesis.

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PMC9429973

Constitutional changes in RNA expression levels and altered metabolism due to ERCC6L2 deficiency may also affect the bone marrow niche and help us understand the disease more profoundly.

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PMC11271278

As illustrated in Fig. 4A, the high copy number of ecDNAs, along with increased chromatin accessibility, results in the overexpression of oncogenes such as EGFR in glioblastoma.

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PMC11461025

Given the evidence that isoginkgetin exhibits anti-cancer properties, we were interested in examining its effects on a mammalian melanoma (A375) cancer cell line.

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PMC11277157

Testing the induction of RULC vs. naïve, non-treated cells shows the upregulated set of coding transcripts (total of 75 genes, marked interferon stimulation, Figure 4).

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PMC8956657

For example, mutations within both the minor site (Arg24Ala), and the major site (Arg33Ala and Arg37Ala) resulted in the MERS-CoV ORF4b binding using a canonical Lys P2 involving TKKLR, with Lys binding at the P2 site.

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PMC11545868

Additionally in the study of Hua, F., et al., daidzein has been shown to have anticancer effects on ovarian cancer through mitochondrial-mediated apoptosis, cell cycle arrest, and inhibition of the Raf/MEK/ERK pathway (Table 1) .

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PMC5925824

NCI-H292, HCC827, and A204 cells were stained for PD-L1 using FITC-conjugated anti-human PD-L1 commercial antibody (clone MIH1, BD Biosciences), Alexa Fluor® 488-conjugated LY3300054, or appropriate isotype controls.

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PMC11680982

Therefore, it is necessary to further validate the findings of this study in the clinic.

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PMC11791264

In summary, we have identified a methylation-dependent regulatory mechanism controlling LC3B’s role in autophagy for the first time, and the methylation of LC3B can inhibit autophagosome formation and promote cancer cell phenotypes in OC cells.

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PMC11615218

In patients with CLL, Fraietta et al. found that those achieving CR received lower percentages of anti-CD19 CAR-T cells expressing PD-1 combined with either TIM3 or LAG3, compared with patients achieving partial or no response.

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PMC9429973

Furthermore, phosphorylation of phospho-SMAD2/3 was found to be significantly lower in post-ATG (2052 ± 428, mean fluorescence intensity, n=4) compared to pre-ATG (3323 ± 32; p=0.03) treated cells.

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PMC9429973

Results: CPX-351 was administered to 74 patients as first induction chemotherapy.

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PMC11422497

These non-coding RNAs feature a covalently closed loop structure, making them resistant to exonucleases and providing stability.

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PMC8584319

The anti-phospho 4E-BP1 (Ser65), anti-4E-BP1, anti-phospho ERK 1/2, anti-ERK 1/2, anti-phospho p38, anti-p38, anti-phospho-JNK, anti-JNK, anti-phospho eIF2α, anti-eIF2α, anti-phospho c-Jun, anti-c-Jun, and horseradish peroxidase-conjugated secondary antibodies were obtained from Cell Signaling Technology (Danvers, MA, ...

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PMC9611901

Therefore, we chose the HepG2 cell model for this pilot study, which is considered useful for investigating the genotoxicity of compounds with unknown or poorly known mechanisms of action .

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PMC11348300

On the day of the initial use, mice were anesthetized, and ALA was either injected i.p.

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PMC11607638

The RNAi and SK peptide injection experiments revealed that SK and SKR are important to regulate blood meal intake and satiety in A. aegypti (Figures 2 and 3).

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PMC9429973

Comparison between groups was performed by Mann Whitney test for continuous variables and Chi-Square test for Categorical variables.

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PMC9646302

In gliomas, high RAC1 expression promotes tumor migration and invasion by inducing epithelial-mesenchymal transition and increasing matrix metalloproteinase expression .

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PMC11661024

Fig. 3Flow cytometer graphs are presented for assessing apoptosis provoked by postbiotic derivate from Lactobacilli sp. at 24 h in A control cell, B IC50 concentration of postbiotic derivate from L. fermentum CH.,

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PMC11701801

Therefore, we examined the potential for expansion/adaptation of CBP/p300 dual inhibitors to cancers carrying abnormal SWI/SNF constituent genes.

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PMC10957991

To assess how TRPV4 is expressed in the normal mammary epithelium and whether it is found in the contractile mammary epithelial basal layer, we utilized immunohistochemical, IHC, stainings of the mammary gland tissue slices as well as two normal human mammary epithelial cell lines, MCF10A and 184A1, containing a mixtur...

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PMC3730428

In cells in which procaspase 8 was depleted, the apoptosis induced by SAHA and AT-IAP/TNFα cotreatment was completely abrogated (Figure 7d), indicating that the mechanism of cell death is caspase eight-dependent, consistent with a FLIP-dependent mechanism (Figure 7b).

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PMC10079526

Viability dose response curves were plotted individually per cell line.

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PMC11411131

Krabx2-Sec is a tandem repeat of Krab fused with TetR and Sec and was predicted to intensify trans-repression.

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PMC11741577

As shown in Fig 2D, in HaCaT cell migration assays, the wound closure rate was highest when HMC-1 cells were treated with the TLR2/6 agonist FSL-1 for 24 hours, compared to other TLR agonists.

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PMC8740518

Therefore, we speculate that cancer can lower cholesterol levels.

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PMC11638288

The presence of these NKp46LTi cells induces the upregulation of adhesion molecules in tumor vasculature, leading to increased leukocyte infiltration.

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PMC11413393

Data are presented as the mean ± SEM and p-values are calculated by 2-way ANOVA with repeated measures and Sidak’s multiple comparisons test.

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PMC4270159

p-AKT S473.

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PMC11703896

Rapamycin binds with FKBP12 (FK505 Binding protein) and the resulting complex binds to the mTORC1 through the FRB domain.

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PMC9895440

c Representative flow cytometry plots and quantification of SNX9 expression measured by antibody staining in flow cytometry of human CD8 T cells of the ex vivo model with the different conditions.

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PMC11643491

No significant difference in cytotoxic effect was observed between A375+ and A375− cells treated with spherical drug-loaded particles.

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PMC8097906

The quantification revealed significant actin-stabilizing properties of VSM10 and VSM25 shown by a significant 1.7- to 2.6-fold increase respectively in filament length and filament number.

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PMC11488203

Alternatively, MSC-derived EVs/exosomes can also be used as a vehicle for the transport of therapeutic compounds.

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PMC11337594

TER treatment of A375 cells for 24 h, identified by KEGG (gene set enrichment analysis) typical pathway analysis of RNA-seq data.

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PMC10823017

An agarose conjugated PKC−ι antibody was used to pull down PKC-ι from the cell lysates.

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PMC11604830

R corresponds to the right PLN, L to the left PLN, G to a standard reference tube containing pure low‐gelling agar, P to a standard reference tube containing PFCE‐NE in low‐gelling agar (proton concentration 0.66 M), W to a water containing tube.

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PMC11591052

Beyond metabolic enzymes, we also studied the expression of c-Myc and ATF3 as two important transcriptional regulators of glycolysis, one-carbon metabolism, and respiration.

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PMC11721277

Electronic absorption spectra were obtained using a Shimadzu UV-1800 spectrophotometer (Shimadzu Corporation, Kyoto, Japan) in a 10 mm thick quartz cell.

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PMC6222726

This compound was shown to be active against LNCaP (androgen-sensitive human prostate adenocarcinoma) cell line (ED50 1.1 μg/mL) during tests aimed at developing an in vivo Hollow Fiber Assay .

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PMC7685376

This study was approved by the Ethics Committee of Shanghai Municipal Hospital of Traditional Chinese Medicine and conducted in accordance with the Declaration of Helsinki.

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PMC3681794

Untreated controls were exposed to the same concentration ranges of cisplatin, doxorubicin and etoposide in normoxia and hypoxia.

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PMC6835428

Prolonged peritoneal persistence can present an advantage, as ovarian cancer metastasis typically colonizes the mesothelial cell layer without affecting the basal lamina .

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PMC9014716

PS-T significantly inhibited the viability of human HepG2 and Bel-7404 cells in a dose-dependent manner at 48 and 72 hours (Figures 1A and B).

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PMC8584666

Statistical analyses methods are indicated in each figure legend, and the calculations were performed using the GraphPad Prism software, version 5.03 (San Diego, CA, USA).

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PMC9878278

We found that exogenous treatment with recombinant TGF-β1 or Activin A at both lower (data not shown) and higher (Figure 5B) concentrations showed no significant change in ZIKV RNA.

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PMC11434983

This effect was reported at 1 μΜ concentration, even lower than the cytotoxicity IC50 concentration.

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