OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11705067	However, the potential role of cuproptosis and its related genes in clear cell renal cell carcinoma (ccRCC) remains elusive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",...
PMC9429973	Acknowledgments: Financial support from FCT/MCTES through national funds to Applied Molecular Biosciences Unit (UCIBIO), UIDP/04378/2020 and UIDB/04378/2020 and the project LA/P/0140/2020 of Associate Laboratory Institute for Health and Bioeconomy (i4HB).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5925824	All animal studies were approved by the Institutional Animal Care and Use Committee and performed in accordance with current regulations and standards of the United States Department of Agriculture and the National Institute of Health.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7305184	One part was exposed to pulse treatment and then transferred to the new growing flask.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "part", "was", "exposed", "to", "pulse", "treatment",...
PMC11687663	To validate docking results using PyMol 2.5.2 software, the procedure involved loading both the co-crystal native ligand and docked complex structures, superimposing the structures for alignment, and calculating the root mean square deviation (RMSD) between the docked ligand and the reference co-crystal ligand.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3035438	The use of monoclonal antibodies (mAbs) has raised considerable interest in recent years, notably for diagnostic and therapeutic applications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "use",...
PMC9684669	Nuclear staining of MDR ovarian cancer cells treated with the indicated concentration of doxorubicin (Dox), terfenadine (Ter) or both.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC5925824	Human PD-L1-Fc was purified via standard ProA affinity columns; human PD-L1 monomer was cleaved from the purified Fc construct with Factor Xa enzyme.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11768927	Strategies that normalize tumor blood vessels (e.g., through anti-angiogenic therapy) can improve virotherapy by facilitating viral delivery to the tumor core.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10748106	Geniposide and its aglycone Genipin have been assessed against different types of cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Geniposide", "and", "its", "aglycone", "Genipin", "have", "been", "assessed...
PMC11724582	After 24 h of cultivation, 500 µL of 4% polymerization solution was added for 20 min of fixation, followed by the addition of 500 µL of 1% crystal violet solution for an additional 20 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10092581	The reaction was initiated by the addition of 3 mM DTNB to both the sample and the reference and the increase in absorbance was monitored at 412 nm for about 15 min at 25 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525028	Chromatin (4×10 cells) and 2.5 μL of ATF4 antibody were used for ChIP assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chromatin", "(", "4", "×", "10", ...
PMC11257203	Data represent the mean ± SD of three separate experiments. ***	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represent", "the", "mean", "±", "SD", "of", "three", "separat...
PMC10530622	Glyoxylate is both a product and a precursor of glycolate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glyoxylate", "is", "both", "a", "product", "and", "a", "precursor", "of", "glycolate", "."...
PMC11670954	BA provides essential energy for colon cells and is vital for maintaining the integrity of the intestinal epithelium .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BA", "provides", "essential", "energy", ...
PMC11798926	Specifically, coexpression of SynDIG4 with GluA1 or GluA1 + GluA2 in Xenopus oocytes slows their deactivation kinetics (Matt et al., 2018), indicating that SynDIG4 interacts directly with AMPARs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11538390	Statistical significance was determined using the Student’s t test (two-tailed).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "was", "determined", "using", "the", "Student", ...
PMC8358006	e Analysis of grand H3K27me3 domains mediated multiplexed interactions by categorizing all interactions into grand H3K27me3 domains to single interaction (1), double interaction (2), and multiplexed interaction (>3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11779605	Comparison of the demographics of the patients with low versus high FGF7 protein levels showed no significant differences in age, race, body mass index (BMI), tumor histology, cancer stage, blood cancer antigen 125 (CA-125), or exposure to bevacizumab in their treatment regimen ( Table 3 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7192625	The legend at the center that can be opened from the option on the left-viewer shows the mapping between features and visual properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11676674	The other compounds were deduced based on the m/z value, retention time, and fragmentation pattern.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "other", "compounds", "were", "deduced", ...
PMC10933092	BLCA and adjacent normal tissues located 2 cm away from the cancer tissue were collected within 1 h of bladder isolation surgery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BLCA", "and"...
PMC7215722	Caco-2 cells are used as an in vitro model for the intestinal barrier due to their ability to differentiate into a monolayer that exhibits properties typical for absorptive enterocytes .	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817	Its straightforward chemistry, symmetrical structure, and multiple sites for hydrogen replacement make it an attractive target for chemists to synthesize its derivatives .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11391695	In line with findings reported in the literature, our qRT-PCR analyses revealed that the mRNA level of KCNN4 was the only one to decrease in SK-Hep-1 cells treated with pcDNA-ACYP2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC11321678	We found that the NTR expression profile was sufficient to classify the samples into four subgroups that were highly consistent with the established MB subgroups by methylation assays and genetic profiles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594806	In healthy individuals, CD73 helps maintain self-tolerance by acting as an immune-inhibitory checkpoint molecule, promoting the infiltration of regulatory immune cells like Tregs, MDSCs, and dendritic cells (DCs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10936243	However, many veterinary practices around the world do not meet basic post-operative cat care, thereby compromising cat welfare.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "many", ...
PMC11343332	Double labeling using the orange dye acridine (AO) and a substance called ethidium bromide (EtBr) to determine the manner of cell death By using AO/EtBr dual staining, it was also possible to assess how a medicine affected cancer cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: In our population of well treated patients, generally not heavily loaded at the cardiac level, native T1 and ECV values turned out to be a associated with heart failure, more strongly than global heart T2* values.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11389534	Meiotic recombination 11 homolog 1 (MRE11) undergoes UFMylation on residue K282 in response to DNA double‐strand breaks (DSBs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Meiotic", "r...
PMC11763126	To verify whether CBDP1 exerts its anticancer effects by regulating TRPM3 expression, we constructed TRPM3 overexpression plasmids for rescue experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "verify", "w...
PMC11530949	Additionally, this study has evaluated nitric oxide levels (NO), reactive oxygen species (ROS) production, Bax, Bcl2, P53, and Caspase3 genes expression, as well as cell viability within 24 hours in liver cancer cell line HepG2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731161	B RT-qPCR analysis of USP7 mRNA levels in MM cell lines with varying sensitivity to SEL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "RT-qPCR", "analysis", "of", "USP7", "mRNA", ...
PMC11762280	D Representative images of H&E staining and TUNEL staining of mice skin sections after different UVB irradiation doses and times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Representative", "image...
PMC10135767	Integrin α4β7, a homing receptor molecule, can mediate circulating lymphocytes to roll and arrest on the vascular endothelia of mucosal tissues by interacting with mucosal vascular address in cell adhesion molecule-1 (MAdCAM-1) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9841531	To prove that the cell death of MCT1-expressing cancer cells results from glucose deprivation, we conducted additional MTT-based cell viability experiments with compounds 24 and 30 supplementing glucose (25 and 50% of the original glucose concentration of 4.5 g/L every 12 h) over a time span of 72 h. Strikingly, we cou...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7841189	This study was performed with approval from the animal ethics committee of Linyi Tumor Hospital.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "was", "performed", "with", "approval", "fr...
PMC9739791	It was established that the prodrug exhibits its toxicity by damaging mitochondria and the endoplasmic reticulum instead of the nucleus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "established", ...
PMC11704834	In conclusion, these results indicate a novel role of TLE1 in modulating EGFR-TKI sensitivity in lung cancer cells via regulation of E-cadherin expression, and its upregulation may potentiate EGFR-TKI resistance in LUAD.Non-small cell lung cancer (NSCLC) is a highly aggressive disease with lung adenocarcinoma (LUAD), t...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9792775	All cells were cultured at 37°C in a humidified atmosphere containing 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cells", "were", "cultured", "at", "37", "...
PMC11126803	E, the core sequence of ERE#2 was mutated by replacing it with the BamH1 restriction site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", ",", "the", "core", "sequence", "of", ...
PMC11525028	After that, the membrane was incubated with species-matched secondary antibodies at room temperature for 1 h. The visualization of target protein bands was achieved using the High-sig ECL substrate (Tanon, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10926885	After IFNb treatment, the expression level of NDE1 in the LLC_RTM28723893 cohort was significantly lower than that in the other treatment groups and baseline (Figure S8B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371747	while the cells do not have natural PCFT; CHO/C5 mock, cells transfected with an empty vector; LF, low folate; HF, high folate; RFC-, RFC-deficient; RFC+++, RFC overexpression; PCFT−, PCFT-deficient; PCFT++, PCFT overexpression; FRα−, FRα deficient; FRα++, overexpression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6889484	Western blot analysis of puromycin-resistant CEM/D128K and PM1/D128K cell lines (n = 5).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "analys...
PMC10237474	Since the development of the stable HEK293S GnTI cell line via chemical mutagenesis by Reeves et al. in 2002 , multiple groups have used this cell line to express and purify homogeneous proteins for which high-resolution structures were successfully determined .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9512971	The protocol specified that an interim analysis should be performed only if recruitment proved difficult because of the convergence of the COVID-19 pandemic during the enrollment period.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6684588	Skeletal muscle homeostasis is critically dependent on interactions between myofibers and multiple types of non-myofiber cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Skeletal", "muscle", "homeostasis", "is", "critically", ...
PMC7762347	The induction of DNA DSBs by CYN, MCLR and their binary mixtures was studied after 24 and 72 h exposure by detection of γH2AX positive cells using flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629192	CSF anti-NMDAR antibody became negative after the first dose of OFA treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CSF", "anti-NMDAR", "antibody", "became", "negative", "after", "the", "first", "...
PMC9031474	Despite the long history of natural products as anticancer drugs, their potential has not been exhausted so far.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "the", "long", "history...
PMC9429973	Pts received TAG intravenous infusions at 12 mcg/kg once daily on days 1–5 of a 21-day cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "received", "TAG", "intravenous", "infusion...
PMC8358176	Following the cell confluency reached 70%, the cells were washed with PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "the", "cell", "confluency", "reached", "70", "%", "...
PMC11720808	Quantification of 143B cell proliferation shown in (D). (	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "143B", "cell", "proliferation", "shown", "in", "(", "D", ...
PMC11576293	We investigated the wound-healing activities of compounds 22 and 29 in A-549 cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "investigated", "the", "wound-healing", "activities", "of", "comp...
PMC11767725	These findings underscore the potential role of systemic metabolic dysfunctions, including insulin resistance, in the pathogenesis of rosacea and its associated cardiovascular risks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11739670	Equilibrium dissociation constants of CD8αβ‐Fc (light grey bars with red circles) and CD8αα‐Fc (dark grey bars and blue circles) binding to a number of MHCI alleles with different peptides and MR1 loaded with different cargoes, measured by SPR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	Tumor cells exhibited nuclear shrinkage and rupture with intense staining, indicating an increase in apoptotic cells (Fig. 4E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor", "cells", ...
PMC10170482	Plane images were processed using the ImageJ software (NIH). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plane", "images", "were", "processed", "using", "the", "ImageJ", "software", "("...
PMC9429973	Eltrombopag is not currently approved for the treatment of SAA in China.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eltrombopag", "is", "not", "currently", "approved", "for", "the", "treatment", "...
PMC11721064	Conversely, skin cells exhibited high expression of genes such as mature keratinocytes markers krt10, krt1 , keratinocytes development regulator SOX4 , CXCL14 , H19 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11750165	Detection of the three genotypes was performed using a polymerase chain reaction-restriction fragment length polymorphism ass (PCR-RFLP) (Fig. 4D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Detecti...
PMC11469524	Fig 1D grey and black arrows) and (b) BL-2-derived final network (cf.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig", "1D", "grey", "and", "black", "arrows", ")...
PMC11515150	Surface expression of the CD5 CAR constructs (top panel) and CD5 molecule (bottom panel) on transduced T cells measured by flow cytometry on day 12. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	and i.cv.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "and", "i.cv", "." ] } ]
PMC11711871	rats fed standard (NSD) and high-salt (HSD) diets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "rats", "fed", "standard", "(", "NSD", ")", "and", "high-salt", "(", "HSD",...
PMC11767582	HRMS (ESI/Q-TOF): m/z [M+H] calcd.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HRMS", "(", "ESI/Q-TOF", "):", "m/z", "[", "M+H", "]", "calcd", "." ] } ]
PMC9559528	Skin biopsies from the posterior trunk and lower leg revealed epidermal hyperplasia of the stratum spinosum and stratum corneum with the presence of Munro-Saboureau microabscesses, collections of neutrophils in the epidermal stratum corneum, which are pathognomonic for psoriasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656048	It was reported that the expression of Nrf2 in OS tissue was significantly higher than the normal peritumoral bone tissue, and it was closely associated with poor prognosis in OS patients (Zhang et al., 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190062	p ≤ 0.001, *p ≤ 0.001, **p ≤ 0.0001. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "≤", "0.001", ",", "*",...
PMC10957991	Oil wd = 0.10 objectives.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oil", "wd", "=", "0.10", "objectives", "." ] } ]
PMC9429973	The outcome of pts failing standard of care regimens, which is now defined as triple-refractory, is poor, with a median progression-free survival (PFS) of 3-4 months and OS of 8-9 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The EORTC QLQ-C30 contains 30 questions comprising 5 functional, 9 individual symptoms, and one global health status/QoL item(s), where a ≥10-point change in score is considered clinically meaningful.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: An unanchored matching-adjusted indirect comparison (MAIC) was conducted to compare efficacy results of patients treated with teclistamab in MajesTEC-1 with those treated with sel-dex in the single-arm, phase 2b STORM Part 2 study (NCT02336815).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9847912	There are few studies of HIV-2 maturation in the published literature, and structures of the mature and immature HIV-2 CA lattices are not yet available.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Pegcetacoplan (PEG), an FDA/EMA-approved targeted C3 therapy for the treatment of PNH, can control intravascular and prevent extravascular hemolysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pegceta...
PMC6133382	The purified products were assayed for protein yield and ability to bind the glycan-dependent broadly neutralizing antibody (bNAb) PG9 by fluorescent immune assay (FIA) (Fig 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	The later identified reactive TCR is highlighted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "later", "identified", "reactive", "TCR", "is", "highlighted", "." ] } ]
PMC10975211	The primary goal of the researcher is to develop new medicines that target cancers while also extending survival times, reducing unfavorable side effects, and improving patient quality of life .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Bone fractures in the anamnesis, dental caries, obesity, biochemical parameters of blood (amino acids in urine, serum ferritin (SF), serum alkaline phosphatase (AF), cholesterol, calcium, vitamin D, free thyroxine, thyroid-stimulating hormone, pituitary hormone, cortisol) as IBD were evaluated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8922418	Based on these properties, Cas13a can be used to target HIV-1 genomic RNA and incoming RNA in infected cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "these", ...
PMC10197932	As shown in Figure 9E and Figure 9F, after 2T treatments, lymphocytes do not show any increase in total ROS, on the contrary, they have a low level of ROS like the control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10582049	The stratification was based on the SILA score—a computerized scoring system designed for predicting LUAD behavior and estimating patient survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "strat...
PMC9429973	Despite 78% of patients being ineligible for ZUMA-2, the responses, CRS, ICANS and survival outcomes were comparable to ZUMA-2 data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10898159	It seems that TFs forming the regulatory network exclusively act on the enhancers of KIT gene in GIST, showing its rudiment [62, 68–70].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10607604	The other two cell lines showed intermediate expression levels (52% and 40% of the KURAMOCHI cell level for COV-318 and OVCAR-3 cells, respectively) (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "...
PMC9516447	The quantitation of the relative protein levels of GRP78 and KRAS after normalization to the GADPH levels is shown in the graphs below.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11576293	This form differs from the other thiolactam form (b-form) by having new signals at δ 9 and 10 ppm corresponding to N1-H (c.f.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11737091	Colony formation assay for 786-O and A498 cells after DBF4 expression was knocked down.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Colony", "formation", "assay", "for", "786-O", "and", ...
PMC6379402	Thus, we show that NUDT8 is likely to have a role in cancer, whose experimental validation will be the subject of a future study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10728535	For example, the hypomethylation of the promoter region of TMEM88 gene in OC leads to an increase in its protein expression and development of cisplatin‐resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11544771	Analyzed by the Chou–Talalay method , when CPX concentrations were ≤5 μM, the combination index (CI) values of CPX/PRE were <1.0, indicating synergism (Figure 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5034105	Alternatively, these animal species may be susceptible hosts with less importance in the transmission cycle, which is analogous to horses for JEV and many vertebrate species for WNV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10809689	After binding of the Gal-9 ligand to the TIM-3 receptor on the surface of AML leukemic cells through autocrine or paracrine pathways, the PI3K/AKT/mTORC signaling pathway is activated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10968586	Effects of HT on cell cycle and induction of apoptosis in replicating cells seemed to be related to an increase in cyclin D3 flanked by a decrease in CDK6 when HT concentration was 100 μM, whereas it was linked to an increase in p21 and p27 mRNA and protein levels when HT was used at a concentration of 75 μM. As sugges...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9398137	All animals were maintained in a pathogen-free environment in individually ventilated cages and provided with sterilized food and water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "animals", "were", "maintai...
PMC11791478	Lung findings included interstitial inflammation, alveolar macrophages, and/or squamous metaplasia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lung", "findings", "included", "interstitial", "inflammation", ",", "alveolar", "macro...
PMC9429973	Image: Summary/Conclusion: In our experience, intralesional rituximab is a safe, accessible, and effective therapeutic option.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclu...

PMC11705067

However, the potential role of cuproptosis and its related genes in clear cell renal cell carcinoma (ccRCC) remains elusive.

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PMC9429973

Acknowledgments: Financial support from FCT/MCTES through national funds to Applied Molecular Biosciences Unit (UCIBIO), UIDP/04378/2020 and UIDB/04378/2020 and the project LA/P/0140/2020 of Associate Laboratory Institute for Health and Bioeconomy (i4HB).

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PMC5925824

All animal studies were approved by the Institutional Animal Care and Use Committee and performed in accordance with current regulations and standards of the United States Department of Agriculture and the National Institute of Health.

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PMC7305184

One part was exposed to pulse treatment and then transferred to the new growing flask.

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PMC11687663

To validate docking results using PyMol 2.5.2 software, the procedure involved loading both the co-crystal native ligand and docked complex structures, superimposing the structures for alignment, and calculating the root mean square deviation (RMSD) between the docked ligand and the reference co-crystal ligand.

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PMC3035438

The use of monoclonal antibodies (mAbs) has raised considerable interest in recent years, notably for diagnostic and therapeutic applications.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "use",...

PMC9684669

Nuclear staining of MDR ovarian cancer cells treated with the indicated concentration of doxorubicin (Dox), terfenadine (Ter) or both.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC5925824

Human PD-L1-Fc was purified via standard ProA affinity columns; human PD-L1 monomer was cleaved from the purified Fc construct with Factor Xa enzyme.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11768927

Strategies that normalize tumor blood vessels (e.g., through anti-angiogenic therapy) can improve virotherapy by facilitating viral delivery to the tumor core.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10748106

Geniposide and its aglycone Genipin have been assessed against different types of cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Geniposide", "and", "its", "aglycone", "Genipin", "have", "been", "assessed...

PMC11724582

After 24 h of cultivation, 500 µL of 4% polymerization solution was added for 20 min of fixation, followed by the addition of 500 µL of 1% crystal violet solution for an additional 20 min.

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PMC10092581

The reaction was initiated by the addition of 3 mM DTNB to both the sample and the reference and the increase in absorbance was monitored at 412 nm for about 15 min at 25 °C.

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PMC11525028

Chromatin (4×10 cells) and 2.5 μL of ATF4 antibody were used for ChIP assays.

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PMC11257203

Data represent the mean ± SD of three separate experiments. ***

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PMC10530622

Glyoxylate is both a product and a precursor of glycolate.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glyoxylate", "is", "both", "a", "product", "and", "a", "precursor", "of", "glycolate", "."...

PMC11670954

BA provides essential energy for colon cells and is vital for maintaining the integrity of the intestinal epithelium .

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PMC11798926

Specifically, coexpression of SynDIG4 with GluA1 or GluA1 + GluA2 in Xenopus oocytes slows their deactivation kinetics (Matt et al., 2018), indicating that SynDIG4 interacts directly with AMPARs.

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PMC11538390

Statistical significance was determined using the Student’s t test (two-tailed).

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PMC8358006

e Analysis of grand H3K27me3 domains mediated multiplexed interactions by categorizing all interactions into grand H3K27me3 domains to single interaction (1), double interaction (2), and multiplexed interaction (>3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11779605

Comparison of the demographics of the patients with low versus high FGF7 protein levels showed no significant differences in age, race, body mass index (BMI), tumor histology, cancer stage, blood cancer antigen 125 (CA-125), or exposure to bevacizumab in their treatment regimen ( Table 3 ).

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PMC7192625

The legend at the center that can be opened from the option on the left-viewer shows the mapping between features and visual properties.

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PMC11676674

The other compounds were deduced based on the m/z value, retention time, and fragmentation pattern.

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PMC10933092

BLCA and adjacent normal tissues located 2 cm away from the cancer tissue were collected within 1 h of bladder isolation surgery.

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PMC7215722

Caco-2 cells are used as an in vitro model for the intestinal barrier due to their ability to differentiate into a monolayer that exhibits properties typical for absorptive enterocytes .

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PMC11767817

Its straightforward chemistry, symmetrical structure, and multiple sites for hydrogen replacement make it an attractive target for chemists to synthesize its derivatives .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11391695

In line with findings reported in the literature, our qRT-PCR analyses revealed that the mRNA level of KCNN4 was the only one to decrease in SK-Hep-1 cells treated with pcDNA-ACYP2.

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PMC11321678

We found that the NTR expression profile was sufficient to classify the samples into four subgroups that were highly consistent with the established MB subgroups by methylation assays and genetic profiles.

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PMC11594806

In healthy individuals, CD73 helps maintain self-tolerance by acting as an immune-inhibitory checkpoint molecule, promoting the infiltration of regulatory immune cells like Tregs, MDSCs, and dendritic cells (DCs).

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PMC10936243

However, many veterinary practices around the world do not meet basic post-operative cat care, thereby compromising cat welfare.

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PMC11343332

Double labeling using the orange dye acridine (AO) and a substance called ethidium bromide (EtBr) to determine the manner of cell death By using AO/EtBr dual staining, it was also possible to assess how a medicine affected cancer cell death.

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PMC9429973

Image: Summary/Conclusion: In our population of well treated patients, generally not heavily loaded at the cardiac level, native T1 and ECV values turned out to be a associated with heart failure, more strongly than global heart T2* values.

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PMC11389534

Meiotic recombination 11 homolog 1 (MRE11) undergoes UFMylation on residue K282 in response to DNA double‐strand breaks (DSBs).

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PMC11763126

To verify whether CBDP1 exerts its anticancer effects by regulating TRPM3 expression, we constructed TRPM3 overexpression plasmids for rescue experiments.

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PMC11530949

Additionally, this study has evaluated nitric oxide levels (NO), reactive oxygen species (ROS) production, Bax, Bcl2, P53, and Caspase3 genes expression, as well as cell viability within 24 hours in liver cancer cell line HepG2.

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PMC11731161

B RT-qPCR analysis of USP7 mRNA levels in MM cell lines with varying sensitivity to SEL.

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PMC11762280

D Representative images of H&E staining and TUNEL staining of mice skin sections after different UVB irradiation doses and times.

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PMC10135767

Integrin α4β7, a homing receptor molecule, can mediate circulating lymphocytes to roll and arrest on the vascular endothelia of mucosal tissues by interacting with mucosal vascular address in cell adhesion molecule-1 (MAdCAM-1) .

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PMC9841531

To prove that the cell death of MCT1-expressing cancer cells results from glucose deprivation, we conducted additional MTT-based cell viability experiments with compounds 24 and 30 supplementing glucose (25 and 50% of the original glucose concentration of 4.5 g/L every 12 h) over a time span of 72 h. Strikingly, we cou...

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PMC7841189

This study was performed with approval from the animal ethics committee of Linyi Tumor Hospital.

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PMC9739791

It was established that the prodrug exhibits its toxicity by damaging mitochondria and the endoplasmic reticulum instead of the nucleus.

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PMC11704834

In conclusion, these results indicate a novel role of TLE1 in modulating EGFR-TKI sensitivity in lung cancer cells via regulation of E-cadherin expression, and its upregulation may potentiate EGFR-TKI resistance in LUAD.Non-small cell lung cancer (NSCLC) is a highly aggressive disease with lung adenocarcinoma (LUAD), t...

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PMC9792775

All cells were cultured at 37°C in a humidified atmosphere containing 5% CO2.

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PMC11126803

E, the core sequence of ERE#2 was mutated by replacing it with the BamH1 restriction site.

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PMC11525028

After that, the membrane was incubated with species-matched secondary antibodies at room temperature for 1 h. The visualization of target protein bands was achieved using the High-sig ECL substrate (Tanon, China).

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PMC10926885

After IFNb treatment, the expression level of NDE1 in the LLC_RTM28723893 cohort was significantly lower than that in the other treatment groups and baseline (Figure S8B).

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PMC11371747

while the cells do not have natural PCFT; CHO/C5 mock, cells transfected with an empty vector; LF, low folate; HF, high folate; RFC-, RFC-deficient; RFC+++, RFC overexpression; PCFT−, PCFT-deficient; PCFT++, PCFT overexpression; FRα−, FRα deficient; FRα++, overexpression.

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PMC6889484

Western blot analysis of puromycin-resistant CEM/D128K and PM1/D128K cell lines (n = 5).

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PMC10237474

Since the development of the stable HEK293S GnTI cell line via chemical mutagenesis by Reeves et al. in 2002 , multiple groups have used this cell line to express and purify homogeneous proteins for which high-resolution structures were successfully determined .

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PMC9512971

The protocol specified that an interim analysis should be performed only if recruitment proved difficult because of the convergence of the COVID-19 pandemic during the enrollment period.

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PMC6684588

Skeletal muscle homeostasis is critically dependent on interactions between myofibers and multiple types of non-myofiber cells.

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PMC7762347

The induction of DNA DSBs by CYN, MCLR and their binary mixtures was studied after 24 and 72 h exposure by detection of γH2AX positive cells using flow cytometry.

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PMC11629192

CSF anti-NMDAR antibody became negative after the first dose of OFA treatment.

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PMC9031474

Despite the long history of natural products as anticancer drugs, their potential has not been exhausted so far.

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PMC9429973

Pts received TAG intravenous infusions at 12 mcg/kg once daily on days 1–5 of a 21-day cycle.

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PMC8358176

Following the cell confluency reached 70%, the cells were washed with PBS.

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PMC11720808

Quantification of 143B cell proliferation shown in (D). (

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PMC11576293

We investigated the wound-healing activities of compounds 22 and 29 in A-549 cancer cells.

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PMC11767725

These findings underscore the potential role of systemic metabolic dysfunctions, including insulin resistance, in the pathogenesis of rosacea and its associated cardiovascular risks.

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PMC11739670

Equilibrium dissociation constants of CD8αβ‐Fc (light grey bars with red circles) and CD8αα‐Fc (dark grey bars and blue circles) binding to a number of MHCI alleles with different peptides and MR1 loaded with different cargoes, measured by SPR.

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PMC11365427

Tumor cells exhibited nuclear shrinkage and rupture with intense staining, indicating an increase in apoptotic cells (Fig. 4E).

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PMC10170482

Plane images were processed using the ImageJ software (NIH). (

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PMC9429973

Eltrombopag is not currently approved for the treatment of SAA in China.

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PMC11721064

Conversely, skin cells exhibited high expression of genes such as mature keratinocytes markers krt10, krt1 , keratinocytes development regulator SOX4 , CXCL14 , H19 .

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PMC11750165

Detection of the three genotypes was performed using a polymerase chain reaction-restriction fragment length polymorphism ass (PCR-RFLP) (Fig. 4D).

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PMC11469524

Fig 1D grey and black arrows) and (b) BL-2-derived final network (cf.

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PMC11515150

Surface expression of the CD5 CAR constructs (top panel) and CD5 molecule (bottom panel) on transduced T cells measured by flow cytometry on day 12. (

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PMC11787355

and i.cv.

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PMC11711871

rats fed standard (NSD) and high-salt (HSD) diets.

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PMC11767582

HRMS (ESI/Q-TOF): m/z [M+H] calcd.

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PMC9559528

Skin biopsies from the posterior trunk and lower leg revealed epidermal hyperplasia of the stratum spinosum and stratum corneum with the presence of Munro-Saboureau microabscesses, collections of neutrophils in the epidermal stratum corneum, which are pathognomonic for psoriasis.

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PMC11656048

It was reported that the expression of Nrf2 in OS tissue was significantly higher than the normal peritumoral bone tissue, and it was closely associated with poor prognosis in OS patients (Zhang et al., 2016).

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PMC11190062

p ≤ 0.001, ***p ≤ 0.001, ****p ≤ 0.0001. (

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PMC10957991

Oil wd = 0.10 objectives.

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PMC9429973

The outcome of pts failing standard of care regimens, which is now defined as triple-refractory, is poor, with a median progression-free survival (PFS) of 3-4 months and OS of 8-9 months.

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PMC9429973

The EORTC QLQ-C30 contains 30 questions comprising 5 functional, 9 individual symptoms, and one global health status/QoL item(s), where a ≥10-point change in score is considered clinically meaningful.

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PMC9429973

Aims: An unanchored matching-adjusted indirect comparison (MAIC) was conducted to compare efficacy results of patients treated with teclistamab in MajesTEC-1 with those treated with sel-dex in the single-arm, phase 2b STORM Part 2 study (NCT02336815).

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PMC9847912

There are few studies of HIV-2 maturation in the published literature, and structures of the mature and immature HIV-2 CA lattices are not yet available.

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PMC9429973

Pegcetacoplan (PEG), an FDA/EMA-approved targeted C3 therapy for the treatment of PNH, can control intravascular and prevent extravascular hemolysis.

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PMC6133382

The purified products were assayed for protein yield and ability to bind the glycan-dependent broadly neutralizing antibody (bNAb) PG9 by fluorescent immune assay (FIA) (Fig 4).

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PMC11787355

The later identified reactive TCR is highlighted.

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PMC10975211

The primary goal of the researcher is to develop new medicines that target cancers while also extending survival times, reducing unfavorable side effects, and improving patient quality of life .

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PMC9429973

Bone fractures in the anamnesis, dental caries, obesity, biochemical parameters of blood (amino acids in urine, serum ferritin (SF), serum alkaline phosphatase (AF), cholesterol, calcium, vitamin D, free thyroxine, thyroid-stimulating hormone, pituitary hormone, cortisol) as IBD were evaluated.

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PMC8922418

Based on these properties, Cas13a can be used to target HIV-1 genomic RNA and incoming RNA in infected cells.

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PMC10197932

As shown in Figure 9E and Figure 9F, after 2T treatments, lymphocytes do not show any increase in total ROS, on the contrary, they have a low level of ROS like the control.

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PMC10582049

The stratification was based on the SILA score—a computerized scoring system designed for predicting LUAD behavior and estimating patient survival.

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PMC9429973

Despite 78% of patients being ineligible for ZUMA-2, the responses, CRS, ICANS and survival outcomes were comparable to ZUMA-2 data.

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PMC10898159

It seems that TFs forming the regulatory network exclusively act on the enhancers of KIT gene in GIST, showing its rudiment [62, 68–70].

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PMC10607604

The other two cell lines showed intermediate expression levels (52% and 40% of the KURAMOCHI cell level for COV-318 and OVCAR-3 cells, respectively) (Figure 1A).

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PMC9516447

The quantitation of the relative protein levels of GRP78 and KRAS after normalization to the GADPH levels is shown in the graphs below.

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PMC11576293

This form differs from the other thiolactam form (b-form) by having new signals at δ 9 and 10 ppm corresponding to N1-H (c.f.

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PMC11737091

Colony formation assay for 786-O and A498 cells after DBF4 expression was knocked down.

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PMC6379402

Thus, we show that NUDT8 is likely to have a role in cancer, whose experimental validation will be the subject of a future study.

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PMC10728535

For example, the hypomethylation of the promoter region of TMEM88 gene in OC leads to an increase in its protein expression and development of cisplatin‐resistance.

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PMC11544771

Analyzed by the Chou–Talalay method , when CPX concentrations were ≤5 μM, the combination index (CI) values of CPX/PRE were <1.0, indicating synergism (Figure 1C).

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PMC5034105

Alternatively, these animal species may be susceptible hosts with less importance in the transmission cycle, which is analogous to horses for JEV and many vertebrate species for WNV.

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PMC10809689

After binding of the Gal-9 ligand to the TIM-3 receptor on the surface of AML leukemic cells through autocrine or paracrine pathways, the PI3K/AKT/mTORC signaling pathway is activated.

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PMC10968586

Effects of HT on cell cycle and induction of apoptosis in replicating cells seemed to be related to an increase in cyclin D3 flanked by a decrease in CDK6 when HT concentration was 100 μM, whereas it was linked to an increase in p21 and p27 mRNA and protein levels when HT was used at a concentration of 75 μM. As sugges...

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PMC9398137

All animals were maintained in a pathogen-free environment in individually ventilated cages and provided with sterilized food and water.

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PMC11791478

Lung findings included interstitial inflammation, alveolar macrophages, and/or squamous metaplasia.

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PMC9429973

Image: Summary/Conclusion: In our experience, intralesional rituximab is a safe, accessible, and effective therapeutic option.

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