OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC7887261	γH2AX primary antibody (Sigma, Catalog #05-636) and goat anti-mouse secondary antibody, Alexa Fluor 647 (Thermo Fisher, Catalog #A21236) were used to stain cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10873328	The mRNA and protein expression level of TGFBI after knocking down by siRNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mRNA", "and", "protein", "expression", "level", "of", "TGFBI", ...
PMC2944824	High levels of Hr protein expression were observed in the majority of cells at 48 hrs after transfection (figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High", "leve...
PMC11737091	p < 0.05; , p < 0.01; *, p < 0.001 DBF4 knockdown suppressed ccRCC cell migration in vitro. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11392912	Synovium (10 mg) samples were finely chopped, homogenized, and solubilized in TRIZOL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Synovium", "(", "10", "mg", ")", "samples", "wer...
PMC10759659	This might be an alternative mechanism of DDR impairment and TMB-H in ARID1A deficiency in HBV-HCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "might", "be", "an", "alternative", "mechanism"...
PMC8348645	Several medicinal plants have been found to possess anticancer properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "medicinal", "plants", "have", "been", "found", "to", "possess", "anticancer", "proper...
PMC11656657	In the RD model, CAR.GD2 T-cells exhibited significant antitumor activity until the second round of tumor exposure compared to NT T-cells (the residual tumor cells at day + 10 was equal to 52.5% ± 18.0% for CAR.GD2 and 92.6% ± 3.4% for NT T-cells, ≤ 0.001; Fig. 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615218	b T cells linearly differentiate to various memory subsets following cancer antigen stimulation, losing proliferation potential, but gaining effector functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "T", ...
PMC9429973	Sociodemographic (including whether regular hospital visits) and clinical factors at diagnosis and treatment regimens were recorded, and univariate and multivariate analyses were performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10956161	The K122/142R mutation is the main Sumo1 binding site in the PRDX6 gene, which can increase the abundance of glutathione peroxidase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "K122/...
PMC5925824	Panel b: Position N63 on human PD-L1 is a specificity anchor for LY3300054.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Panel", "b", ":", "Position", "N63", "on", "human", "PD-L1", ...
PMC11770130	Similarly, NTRC-824 may have unknown off-target effects other than inhibiting the activity of NTSR2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "NTRC-824", "may", "have", "unknown", "off...
PMC7192625	This is also confirmed looking at the cross-ChAsz-score (Supplementary Figure S6e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "also", "confirmed", "looking", "at", "the", "cross-ChAsz-scor...
PMC11782780	Results indicated that the upregulation of EBF3 weakened the promotive effect of miR-301b-3p overexpression on glycolysis (Fig. 5F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "indicated", "that...
PMC11707832	In the central nervous system (CNS), its expression appears notably elevated in the corpus callosum and spinal cord.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "cent...
PMC8751435	Therefore, pyroptosis and capsase‐3‐mediating effect are chosen for validating anticancer mechanism of CME in our research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "pyroptosis", "and", "capsase‐3‐...
PMC10747139	In normal Vero cells, 46 showed almost the same activity, whereas 47 was even more active than it was against tumor cells.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC9429973	Summary/Conclusion: Anti-epidemic measures taken at the center have shown effectiveness in reducing the spread of nosocomial infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Anti-epidemic", "...
PMC11506827	GEF-mediated MuD modulation presents a mechanism through which ginseng-derived compounds influence cell fate determinants, particularly in RCC, where resistance to apoptosis is a significant challenge in treatment strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607764	Prognostic and predictive biomarkers such as PD-L1 expression, tumor mutational load, and neutrophil/lymphocyte ratio have been identified in immunotherapy for renal cell carcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	29 patients (14%) presented a grade ≥3 ICANS with axi-cel compared with 6 (3%) only with tisa-cel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "29", ...
PMC9812014	Another alkaloid—homoharringtonine (HHT)—has been reported as an anti-PEDV agent in vitro and in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "alkaloid", "—", "homoharringtonine", "(HHT)—has",...
PMC11739484	These cell lines were cultured under standard conditions in Dulbecco’s Modified Eagle’s Medium (DMEM) or RPMI-1640 medium supplemented with 10% fetal bovine serum (FBS) and antibiotics, and maintained at 37 °C in a humidified atmosphere containing 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11696576	Introduction of the methyl on GK470 (compound GK402) resulted in considerable loss of inhibitory activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Introduction", "of", "the", "methyl", "on", ...
PMC10047551	PD-L1 mRNA expression was inversely correlated with the DNA methylation of cg19724470 (Spearman r = −0.88, p = 0.0002) and cg(chr9:5450951) (Spearman r = −0.78, p = 0.0025) (Figure 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11698348	Mice were then allowed to recover on the heating pad and returned to their cages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mice", "were", "then", "allowed", "to", "recover", "on", ...
PMC9429973	Methods: Patients (6–35 y of age) with TDT receiving packed red blood cell (pRBC) transfusions of ≥100 mL/kg/y or ≥10 units/y in the previous 2 y were eligible.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240	Cells were left untreated as further control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "left", "untreated", "as", "further", "control", "." ] } ]
PMC11590005	Bolded values indicate statistically significant difference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bolded", "values", "indicate", "statistically", "significant", "difference", "." ] } ]
PMC11792090	Despite the promising preclinical outcomes, we realize that several limitations need to be addressed to improve our SAP UCAR-T therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "the", ...
PMC11594806	ATP release channels also play a role in osteosarcoma (OS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ATP", "release", "channels", "also", "play", "a", "role", "in", "osteosarcoma", ...
PMC11489175	USP8 has been also implicated in the regulation of apoptotic cell death 94 that can results from decreased survival signals by receptor tyrosine kinases, but also from changes in stability of anti-apoptotic proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679033	Then, the preparation of microscopic slides started, which included harvesting of cells by centrifugation (100× g, ROTOFIX 32A centrifuge, Hettich, Tuttlingen, Germany), followed by hypotonic treatment (0.075 mol/L KCl; Kemika, Zagreb, Croatia), and a new round of centrifugation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: Patients diagnosed with DLBCL with high levels of DEK oncogene expression have worse responses to treatment and lower overall survival compared to patients with lower levels of expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11538390	One set of variants comprised a 62 kb-long haplotype of strongly correlated variants upstream of IRF6, with the lead SNP rs7546104 reaching a P value of 9.53 × 10 (OR = 1.95, Table 1, Supplementary Fig. 2a, b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	The high QPPCaco, QPPMDCK, and Human Oral Absorption imply rapid intestinal uptake, high renal permeability, and efficient oral bioavailability (Table 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8875242	A to B and B to A transport were evaluated in terms of an apparent permeability coefficient (Papp), calculated using the equation in .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC4839679	Each observer recorded the number of total cells, as determined by DAPI staining, as well as the number of cells with high concentrations of cortical actin staining as determined by Phalloidin staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607638	Ten mosquitoes were put in one tube, three tubes were used for each group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ten", "mosquitoes", "were", "put", "in", "one", "tube", ...
PMC9250505	Hence, a rational and efficacious combination strategy involving combined inhibition of PARP and BAD phosphorylation may ameliorate the prognosis of recurrent EOC patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8140214	A reduction in absorbance shows oxidation of NADPH through reduction of GS-SG by the activity of enzyme GR in the HepG2 cell lysate which was monitored spectrophotometrically at 340 nm wavelength for 3 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC10743717	Furthermore, biochemists are generally aware that mitochondrial β-hydroxybutyrate dehydrogenase, β-HBD rather than ABAD or 17β-HSD10/HADII is involved in ketone body metabolism (see Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519788	Given that high macrophages infiltration correlates with a poor prognosis in UBC patients, disrupting this detrimental CSC-macrophage cycle represents a promising therapeutic strategy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC3035438	After 24 h of incubation at 37°C in 5% CO2 incubator, single colonies of stable clones were selected in 96-well plates with a medium containing 25 μg/ml Blasticidin S. The positive ch/hu-IgHG1 transformant strain used in this study was named CX13.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11406030	Additionally, recombinant LMTK3 protein treatment of ovarian cancer cells increased the expression of a novel ovarian cancer integrin αV and β1 in a dose-response manner (Figure 6A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11185260	The solution was vortexed for an additional 20 min while cooling down to room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "solution", "was", "vortexed", "for", "an", "addition...
PMC11730320	Initial denaturation was set at 96 °C for 2 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Initial", "denaturation", "was", "set", "at", "96", "°", "C", "for", "2", "min"...
PMC11530949	Conversely, the anti-apoptotic gene Bcl2 was notably downregulated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "the", "anti-apoptotic", "gene", "Bcl2", "was", "notably", "downregulated", "." ] }...
PMC10887351	The β3-AR has been suggested as a potential target for cancer treatment, both in adult and pediatric tumors, since under hypoxia its upregulation in the tumor microenvironment (TME) regulates stromal cell differentiation, tumor growth and metastases, signifying that its agonism/antagonism could be useful for clinical b...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634027	O-R) Histograms illustrating relative wing area (compared to that in ds/ds) (O), roundness (P), cross-vein distance (Q), and PCV loss (R) in the indicated genotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730320	The mutation was confirmed in a clinical laboratory (Fulgent Genetics).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mutation", "was", "confirmed", "in", "a", "clinical", "laboratory", "(", ...
PMC9429973	Fifty-two (19.9%) and 106 (40.5%) pts received subsequent anti-lymphoma therapy in the Ibr and Pbo arms, respectively; 41/106 (38.7%) received a second-line BTKi in the Pbo arm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8270637	Subcutaneous tumors extracted from Kunming mice 14 days after implantation, and the weight of these tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subcutaneous", "tumors", "extracted", "from", "Ku...
PMC7504302	Consistent with human malignancy, the tumors recapitulated the genetic and molecular features of MPM, characterized by the inactivation of the normal allele of the NF2 gene as well as frequent homozygous co-deletions of the CDKN2A and CDKN2B genes and the activation of Akt signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11799978	Our observations show that fibroblasts are an extremely plastic population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "observations", "show", "that", "fibroblasts", "are", "an", "extremely", "plastic", "popul...
PMC10237474	Expi293F stably-expressed proteins also show much less clipping compared to those expressed in CHO-K1 stable pools, and thus our results suggest that Expi293F serves as a good alternative expression host for expressing proteins that are otherwise clipped in CHO-K1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7582629	Shape, morphological defects and optical thickness are also useful parameters, particularly for the discrimination between cells, and may be recorded via holography.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11224020	Data were analyzed by Kruskal–Wallis test; ****P < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "analyzed", "by", "Kruskal", "–", ...
PMC11687167	In turn, E protein activity can be a new player involved in the fine regulation of resting CD4 + T-cell activity and activation, partly due to the regulation of TCR signaling by the PI3K/Akt pathway .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Key secondary objectives include further evaluation of safety and tolerability, characterization of the pharmacodynamics and pharmacokinetics of BMF-219, and assessment of its antitumor activity based on best overall response rate (ORR), duration of response (DOR), progression-free survival (PFS), and time to progressi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11441402	In comparison, the SRB and MTT assays were effective for the adherent cell lines (Figure 3(C–D)), although there was large variability within experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	This indicates that renal excretion does not play a significant role in the elimination of the tested chlorin and that it is dominated by excretion via the hepatobiliary system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: N/A Summary/Conclusion: Phase 2 expansion cohorts for patients with untreated/frontline and relapsed AML are enrolling to further characterize the safety profile and assess the antileukemic activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11528603	In addition, we found that the SA-EA treament decreased the PCNA mRNA expression (Figure 4) and inhibited the growth of HL60 population (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC11617590	When PARP is cut by caspase‐3, its ability to repair DNA is inhibited .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "PARP", "is", "cut", "by", "caspase‐3", ",", "its", ...
PMC11092382	and Daphniphyllum oldhamii (Hemsl.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "and", "Daphniphyllum", "oldhamii", "(", "Hemsl", ".", ")" ] } ]
PMC11334037	Single-group comparisons were done with Student’s t-tests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single-group", "comparisons", "were", "done", "with", "Student", "’s", "t-tests", "." ] } ]
PMC11461833	On this basis, we combined an analysis of a published RNA sequencing (RNA-seq) database with a small-scale short hairpin RNA (shRNA) screen and identified Syntaxin-binding protein 5 (STXBP5) as a potential regulatory factor for progerin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11033180	By contrast, measurements performed in a more distal portion of the axonal arbor (160 μm from the center of the ganglion) showed an increased axonal complexity in the presence of COS cells expressing Sema5A-Fc compared to Fc control condition (n = 6 from 3 independent experiments; p = 0.016, two-way ANOVA with Tukey po...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10761571	According to the results, the nanoparticles had significant toxic effects on cancer cells which reduced the viability of the cells by 15–85 %, depending on the exposure dose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10874773	At the same time, when there is no hydroxy at the C10 position, the compounds have almost no activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "same...
PMC11576293	For C19H18N2O2SCl (M + H) 373.07720; found 373.07750.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "C19H18N2O2SCl", "(", "M", "+", "H", ")", "373.07720", ";", "found", "373...
PMC11718109	F Live fluorescence imaging shows spontaneous calcium activity in DA neurons at day 50.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "Live", "fluorescence", "imaging", "shows", "spontaneous", "calciu...
PMC11742431	Previously, Ibrahim et al. fused the RING domain of ubiquitin E3 ligase RNF4 with a nanobody to obtain an antibody RING‐mediated destruction (ARMeD) degradation platform.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718109	Scale bar, 500 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "500", "nm", "." ] } ]
PMC11746942	To validate these findings in vivo, we employed an IMQ-induced psoriasiform dermatitis mouse model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "validate", "these", "findings", "in", "vivo", ",", ...
PMC11351758	From studies on different tissues in a variety of pathological conditions, a general consensus has emerged with regard to the role of mitochondrial Ca overload as a pivotal link between cellular alterations and mitochondrial dysfunction .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In Spain there are two entities accredited by ENAC for certification in transfusion: Transfusion Accreditation Commitee (CAT) and the Agency for Health Quality of Andalusia (ACSA), although the latter with a specific program limited to transfusion centers not available for hospital practice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In the multi-adjusted linear regression model, participants with younger age (2-4 years= 72.1; 5-7 years= 67.8; 8-12 years = 64.3; 13-17 years= 60.5), without complications (with complications vs. no complications: 61.6 vs. 75.4), shorter course of disease (< 8 years vs. s 8 years: 67.6 vs. 63.8), without iron chemothe...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257988	These targeted drugs are now collectively known as KRASG12C inhibitors, including Sotorasib (AMG 510) from Amgen and Adagrasib (MRTX 849) from Mirati, used to treat non-small cell lung cancer patients with KRASG12C mutations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10197932	Differently, healthy lymphocytes keep, after US-treatment, basal ROS level, have very low depletion of GSH content and can actively proliferate and differentiate after stimulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11317131	Data are shown as mean + s.d. (*)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", "mean", "+", "s.d", ".", "(", "*", ")" ] } ]
PMC10565698	.	[ { "tags": [ "O" ], "tokens": [ "." ] } ]
PMC11240571	The IFN-dependent pathway is considered a common pathway for expressing PD-L1, and it is also responsible for the upregulation of PD-L1 after irradiation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11345828	The organic layer was dried over MgSO4, filtered, and concentrated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "organic", "layer", "was", "dried", "over", "MgSO4", ",", "filtered", ...
PMC7802142	1ReN cell-derived nanovesicles (ReN-NV) preparation and identification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1ReN", "cell-derived", "nanovesicles", "(", "ReN-NV", ")", "preparation", "and", "identification", "." ...
PMC9503541	This evergreen plant is a member of the Annonaceae family and is widely distributed in the rainforests of Central and South America, Africa, and Southeast Asia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11521786	In this scenario, tumor progression is abrogated through shRNA or CRISPR Cas-mediated HER3 silencing (6, 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "scenario", ...
PMC11087301	In a recent study performed by Li and colleagues, chaperon-containing TCP1 subunit 5 (CCT5) was shown to bind E-cadherin cytoplasmic domain overriding its interaction with β-catenin in gastric cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742864	ω-3 LCPUFA effects and mechanisms in lung cancer PSO/RA-RF: perilla seed oil/rosmarinic acid-rich fraction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ω-3", "LCPUFA", "effects", "and", "mechanisms", "in", "lung...
PMC11791478	TF-binding mAbs were isolated through multiple rounds of enrichment, incubating biotinylated TF-His monomers at different concentrations with antibody-expressing yeast cells, followed by magnetic bead selection (Miltenyi Biotech) and FACS on a FACSAria II cell sorter (BD Biosciences) using streptavidin secondary reagen...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306019	By day 14, GA and EGC individually mitigated BTZ-induced cell growth reduction (Figures 5B, C, E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "day", "14",...
PMC11740907	Each formulation’s efficacy against cancer was evaluated using the tumor inhibition rate (TIR). [	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "formulation", "’s", "efficacy", "against"...
PMC7553912	Frozen sections were cut on a cryostat at 6-μm thickness.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Frozen", "sections", "were", "cut", "on", "a", "cryostat", "at", "6-μm", "thickness", "." ...
PMC11401358	Natural SF can efficiently scavenge intracellular ROS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Natural", "SF", "can", "efficiently", "scavenge", "intracellular", "ROS", "." ] } ]
PMC11352877	Hypoxia-inducible factor 1-alpha (HIF-1α) is emerging as another critical component of cell survival and adaptive response function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hypoxia-inducible", "factor", "1-alpha"...
PMC9621239	pRb, phosphorylated Rb. (	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "pRb", ",", "phosphorylated", "Rb", ".", "(" ] } ]
PMC11740907	Quantifying tail DNA as a fraction of total DNA content is a crucial technique used to verify the existence of DNA damage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantifying", ...
PMC5673955	IC50 = 20.7 ± 1.0 U/mL for Jurkat cells and 29.5 ± 3.4 U/mL for CD4 T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "IC50", "=", "20.7", "±", ...

PMC7887261

γH2AX primary antibody (Sigma, Catalog #05-636) and goat anti-mouse secondary antibody, Alexa Fluor 647 (Thermo Fisher, Catalog #A21236) were used to stain cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10873328

The mRNA and protein expression level of TGFBI after knocking down by siRNA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mRNA", "and", "protein", "expression", "level", "of", "TGFBI", ...

PMC2944824

High levels of Hr protein expression were observed in the majority of cells at 48 hrs after transfection (figure 1).

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PMC11737091

p < 0.05; **, p < 0.01; ***, p < 0.001 DBF4 knockdown suppressed ccRCC cell migration in vitro. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11392912

Synovium (10 mg) samples were finely chopped, homogenized, and solubilized in TRIZOL.

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PMC10759659

This might be an alternative mechanism of DDR impairment and TMB-H in ARID1A deficiency in HBV-HCC.

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PMC8348645

Several medicinal plants have been found to possess anticancer properties.

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PMC11656657

In the RD model, CAR.GD2 T-cells exhibited significant antitumor activity until the second round of tumor exposure compared to NT T-cells (the residual tumor cells at day + 10 was equal to 52.5% ± 18.0% for CAR.GD2 and 92.6% ± 3.4% for NT T-cells, ≤ 0.001; Fig. 3B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11615218

b T cells linearly differentiate to various memory subsets following cancer antigen stimulation, losing proliferation potential, but gaining effector functions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "T", ...

PMC9429973

Sociodemographic (including whether regular hospital visits) and clinical factors at diagnosis and treatment regimens were recorded, and univariate and multivariate analyses were performed.

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PMC10956161

The K122/142R mutation is the main Sumo1 binding site in the PRDX6 gene, which can increase the abundance of glutathione peroxidase.

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PMC5925824

Panel b: Position N63 on human PD-L1 is a specificity anchor for LY3300054.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Panel", "b", ":", "Position", "N63", "on", "human", "PD-L1", ...

PMC11770130

Similarly, NTRC-824 may have unknown off-target effects other than inhibiting the activity of NTSR2.

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PMC7192625

This is also confirmed looking at the cross-ChAsz-score (Supplementary Figure S6e).

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PMC11782780

Results indicated that the upregulation of EBF3 weakened the promotive effect of miR-301b-3p overexpression on glycolysis (Fig. 5F).

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PMC11707832

In the central nervous system (CNS), its expression appears notably elevated in the corpus callosum and spinal cord.

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PMC8751435

Therefore, pyroptosis and capsase‐3‐mediating effect are chosen for validating anticancer mechanism of CME in our research.

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PMC10747139

In normal Vero cells, 46 showed almost the same activity, whereas 47 was even more active than it was against tumor cells.

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PMC9429973

Summary/Conclusion: Anti-epidemic measures taken at the center have shown effectiveness in reducing the spread of nosocomial infection.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Anti-epidemic", "...

PMC11506827

GEF-mediated MuD modulation presents a mechanism through which ginseng-derived compounds influence cell fate determinants, particularly in RCC, where resistance to apoptosis is a significant challenge in treatment strategies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11607764

Prognostic and predictive biomarkers such as PD-L1 expression, tumor mutational load, and neutrophil/lymphocyte ratio have been identified in immunotherapy for renal cell carcinoma.

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PMC9429973

29 patients (14%) presented a grade ≥3 ICANS with axi-cel compared with 6 (3%) only with tisa-cel.

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PMC9812014

Another alkaloid—homoharringtonine (HHT)—has been reported as an anti-PEDV agent in vitro and in vivo.

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PMC11739484

These cell lines were cultured under standard conditions in Dulbecco’s Modified Eagle’s Medium (DMEM) or RPMI-1640 medium supplemented with 10% fetal bovine serum (FBS) and antibiotics, and maintained at 37 °C in a humidified atmosphere containing 5% CO2.

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PMC11696576

Introduction of the methyl on GK470 (compound GK402) resulted in considerable loss of inhibitory activity.

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PMC10047551

PD-L1 mRNA expression was inversely correlated with the DNA methylation of cg19724470 (Spearman r = −0.88, p = 0.0002) and cg(chr9:5450951) (Spearman r = −0.78, p = 0.0025) (Figure 1C).

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PMC11698348

Mice were then allowed to recover on the heating pad and returned to their cages.

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PMC9429973

Methods: Patients (6–35 y of age) with TDT receiving packed red blood cell (pRBC) transfusions of ≥100 mL/kg/y or ≥10 units/y in the previous 2 y were eligible.

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PMC11683240

Cells were left untreated as further control.

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PMC11590005

Bolded values indicate statistically significant difference.

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PMC11792090

Despite the promising preclinical outcomes, we realize that several limitations need to be addressed to improve our SAP UCAR-T therapy.

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PMC11594806

ATP release channels also play a role in osteosarcoma (OS).

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PMC11489175

USP8 has been also implicated in the regulation of apoptotic cell death 94 that can results from decreased survival signals by receptor tyrosine kinases, but also from changes in stability of anti-apoptotic proteins.

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PMC11679033

Then, the preparation of microscopic slides started, which included harvesting of cells by centrifugation (100× g, ROTOFIX 32A centrifuge, Hettich, Tuttlingen, Germany), followed by hypotonic treatment (0.075 mol/L KCl; Kemika, Zagreb, Croatia), and a new round of centrifugation.

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PMC9429973

Summary/Conclusion: Patients diagnosed with DLBCL with high levels of DEK oncogene expression have worse responses to treatment and lower overall survival compared to patients with lower levels of expression.

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PMC11538390

One set of variants comprised a 62 kb-long haplotype of strongly correlated variants upstream of IRF6, with the lead SNP rs7546104 reaching a P value of 9.53 × 10 (OR = 1.95, Table 1, Supplementary Fig. 2a, b).

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PMC11790599

The high QPPCaco, QPPMDCK, and Human Oral Absorption imply rapid intestinal uptake, high renal permeability, and efficient oral bioavailability (Table 3).

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PMC8875242

A to B and B to A transport were evaluated in terms of an apparent permeability coefficient (Papp), calculated using the equation in .

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PMC4839679

Each observer recorded the number of total cells, as determined by DAPI staining, as well as the number of cells with high concentrations of cortical actin staining as determined by Phalloidin staining.

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PMC11607638

Ten mosquitoes were put in one tube, three tubes were used for each group.

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PMC9250505

Hence, a rational and efficacious combination strategy involving combined inhibition of PARP and BAD phosphorylation may ameliorate the prognosis of recurrent EOC patients.

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PMC8140214

A reduction in absorbance shows oxidation of NADPH through reduction of GS-SG by the activity of enzyme GR in the HepG2 cell lysate which was monitored spectrophotometrically at 340 nm wavelength for 3 min.

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PMC10743717

Furthermore, biochemists are generally aware that mitochondrial β-hydroxybutyrate dehydrogenase, β-HBD rather than ABAD or 17β-HSD10/HADII is involved in ketone body metabolism (see Figure 2).

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PMC11519788

Given that high macrophages infiltration correlates with a poor prognosis in UBC patients, disrupting this detrimental CSC-macrophage cycle represents a promising therapeutic strategy.

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PMC3035438

After 24 h of incubation at 37°C in 5% CO2 incubator, single colonies of stable clones were selected in 96-well plates with a medium containing 25 μg/ml Blasticidin S. The positive ch/hu-IgHG1 transformant strain used in this study was named CX13.

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PMC11406030

Additionally, recombinant LMTK3 protein treatment of ovarian cancer cells increased the expression of a novel ovarian cancer integrin αV and β1 in a dose-response manner (Figure 6A).

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PMC11185260

The solution was vortexed for an additional 20 min while cooling down to room temperature.

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PMC11730320

Initial denaturation was set at 96 °C for 2 min.

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PMC11530949

Conversely, the anti-apoptotic gene Bcl2 was notably downregulated.

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PMC10887351

The β3-AR has been suggested as a potential target for cancer treatment, both in adult and pediatric tumors, since under hypoxia its upregulation in the tumor microenvironment (TME) regulates stromal cell differentiation, tumor growth and metastases, signifying that its agonism/antagonism could be useful for clinical b...

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PMC11634027

O-R) Histograms illustrating relative wing area (compared to that in ds/ds) (O), roundness (P), cross-vein distance (Q), and PCV loss (R) in the indicated genotypes.

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PMC11730320

The mutation was confirmed in a clinical laboratory (Fulgent Genetics).

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PMC9429973

Fifty-two (19.9%) and 106 (40.5%) pts received subsequent anti-lymphoma therapy in the Ibr and Pbo arms, respectively; 41/106 (38.7%) received a second-line BTKi in the Pbo arm.

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PMC8270637

Subcutaneous tumors extracted from Kunming mice 14 days after implantation, and the weight of these tumors.

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PMC7504302

Consistent with human malignancy, the tumors recapitulated the genetic and molecular features of MPM, characterized by the inactivation of the normal allele of the NF2 gene as well as frequent homozygous co-deletions of the CDKN2A and CDKN2B genes and the activation of Akt signaling.

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PMC11799978

Our observations show that fibroblasts are an extremely plastic population.

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PMC10237474

Expi293F stably-expressed proteins also show much less clipping compared to those expressed in CHO-K1 stable pools, and thus our results suggest that Expi293F serves as a good alternative expression host for expressing proteins that are otherwise clipped in CHO-K1.

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PMC7582629

Shape, morphological defects and optical thickness are also useful parameters, particularly for the discrimination between cells, and may be recorded via holography.

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PMC11224020

Data were analyzed by Kruskal–Wallis test; ****P < 0.0001.

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PMC11687167

In turn, E protein activity can be a new player involved in the fine regulation of resting CD4 + T-cell activity and activation, partly due to the regulation of TCR signaling by the PI3K/Akt pathway .

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PMC9429973

Key secondary objectives include further evaluation of safety and tolerability, characterization of the pharmacodynamics and pharmacokinetics of BMF-219, and assessment of its antitumor activity based on best overall response rate (ORR), duration of response (DOR), progression-free survival (PFS), and time to progressi...

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PMC11441402

In comparison, the SRB and MTT assays were effective for the adherent cell lines (Figure 3(C–D)), although there was large variability within experiments.

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PMC11721277

This indicates that renal excretion does not play a significant role in the elimination of the tested chlorin and that it is dominated by excretion via the hepatobiliary system.

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PMC9429973

Results: N/A Summary/Conclusion: Phase 2 expansion cohorts for patients with untreated/frontline and relapsed AML are enrolling to further characterize the safety profile and assess the antileukemic activity.

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PMC11528603

In addition, we found that the SA-EA treament decreased the PCNA mRNA expression (Figure 4) and inhibited the growth of HL60 population (Figure 1).

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PMC11617590

When PARP is cut by caspase‐3, its ability to repair DNA is inhibited .

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PMC11092382

and Daphniphyllum oldhamii (Hemsl.)

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PMC11334037

Single-group comparisons were done with Student’s t-tests.

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PMC11461833

On this basis, we combined an analysis of a published RNA sequencing (RNA-seq) database with a small-scale short hairpin RNA (shRNA) screen and identified Syntaxin-binding protein 5 (STXBP5) as a potential regulatory factor for progerin.

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PMC11033180

By contrast, measurements performed in a more distal portion of the axonal arbor (160 μm from the center of the ganglion) showed an increased axonal complexity in the presence of COS cells expressing Sema5A-Fc compared to Fc control condition (n = 6 from 3 independent experiments; p = 0.016, two-way ANOVA with Tukey po...

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PMC10761571

According to the results, the nanoparticles had significant toxic effects on cancer cells which reduced the viability of the cells by 15–85 %, depending on the exposure dose.

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PMC10874773

At the same time, when there is no hydroxy at the C10 position, the compounds have almost no activity.

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PMC11576293

For C19H18N2O2SCl (M + H) 373.07720; found 373.07750.

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PMC11718109

F Live fluorescence imaging shows spontaneous calcium activity in DA neurons at day 50.

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PMC11742431

Previously, Ibrahim et al. fused the RING domain of ubiquitin E3 ligase RNF4 with a nanobody to obtain an antibody RING‐mediated destruction (ARMeD) degradation platform.

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PMC11718109

Scale bar, 500 nm.

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PMC11746942

To validate these findings in vivo, we employed an IMQ-induced psoriasiform dermatitis mouse model.

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PMC11351758

From studies on different tissues in a variety of pathological conditions, a general consensus has emerged with regard to the role of mitochondrial Ca overload as a pivotal link between cellular alterations and mitochondrial dysfunction .

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PMC9429973

In Spain there are two entities accredited by ENAC for certification in transfusion: Transfusion Accreditation Commitee (CAT) and the Agency for Health Quality of Andalusia (ACSA), although the latter with a specific program limited to transfusion centers not available for hospital practice.

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PMC9429973

In the multi-adjusted linear regression model, participants with younger age (2-4 years= 72.1; 5-7 years= 67.8; 8-12 years = 64.3; 13-17 years= 60.5), without complications (with complications vs. no complications: 61.6 vs. 75.4), shorter course of disease (< 8 years vs. s 8 years: 67.6 vs. 63.8), without iron chemothe...

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PMC11257988

These targeted drugs are now collectively known as KRASG12C inhibitors, including Sotorasib (AMG 510) from Amgen and Adagrasib (MRTX 849) from Mirati, used to treat non-small cell lung cancer patients with KRASG12C mutations .

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PMC10197932

Differently, healthy lymphocytes keep, after US-treatment, basal ROS level, have very low depletion of GSH content and can actively proliferate and differentiate after stimulation.

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PMC11317131

Data are shown as mean + s.d. (*)

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PMC10565698

.

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PMC11240571

The IFN-dependent pathway is considered a common pathway for expressing PD-L1, and it is also responsible for the upregulation of PD-L1 after irradiation.

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PMC11345828

The organic layer was dried over MgSO4, filtered, and concentrated.

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PMC7802142

1ReN cell-derived nanovesicles (ReN-NV) preparation and identification.

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PMC9503541

This evergreen plant is a member of the Annonaceae family and is widely distributed in the rainforests of Central and South America, Africa, and Southeast Asia.

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PMC11521786

In this scenario, tumor progression is abrogated through shRNA or CRISPR Cas-mediated HER3 silencing (6, 7).

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PMC11087301

In a recent study performed by Li and colleagues, chaperon-containing TCP1 subunit 5 (CCT5) was shown to bind E-cadherin cytoplasmic domain overriding its interaction with β-catenin in gastric cancer cells.

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PMC11742864

ω-3 LCPUFA effects and mechanisms in lung cancer PSO/RA-RF: perilla seed oil/rosmarinic acid-rich fraction.

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PMC11791478

TF-binding mAbs were isolated through multiple rounds of enrichment, incubating biotinylated TF-His monomers at different concentrations with antibody-expressing yeast cells, followed by magnetic bead selection (Miltenyi Biotech) and FACS on a FACSAria II cell sorter (BD Biosciences) using streptavidin secondary reagen...

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PMC11306019

By day 14, GA and EGC individually mitigated BTZ-induced cell growth reduction (Figures 5B, C, E).

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PMC11740907

Each formulation’s efficacy against cancer was evaluated using the tumor inhibition rate (TIR). [

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PMC7553912

Frozen sections were cut on a cryostat at 6-μm thickness.

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PMC11401358

Natural SF can efficiently scavenge intracellular ROS.

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PMC11352877

Hypoxia-inducible factor 1-alpha (HIF-1α) is emerging as another critical component of cell survival and adaptive response function.

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PMC9621239

pRb, phosphorylated Rb. (

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PMC11740907

Quantifying tail DNA as a fraction of total DNA content is a crucial technique used to verify the existence of DNA damage.

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PMC5673955

IC50 = 20.7 ± 1.0 U/mL for Jurkat cells and 29.5 ± 3.4 U/mL for CD4 T cells.

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