PMCID
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PMC9429973
Results: We identified 217 patients who met inclusion criteria for LGLL diagnosis; 196 (90.3%) patients had T-LGLL and 21 (9.7%) patients had NK-LGLL.
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PMC8164677
CD73 (Ecto-5-nucleotidase) is a plasma membrane-bounded protein, found to be overexpressed in a variety of invasive and resistant tumor cells and biopsies of breast, ovarian and many other malignant tissues.
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PMC11765678
Cytotoxicity was assessed by both CellTiter-Glo (Promega, Madison, WI, USA) and Trypan Exclusion methods.
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PMC11583010
Accordingly, the plasma half-life of total antibody was determined as 303.5 hours in ungrafted mice but was reduced to 244.6 hours in PDX TNBC400.
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PMC11513571
The magnet was inverted using a tube to pour the cell suspension into a new tube.
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PMC9429973
Duplication dose of DOAC (0 paper-based vs 1 eMeds).
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PMC11321678
Recently, there is considerable evidence that the origins of this disease are related to the development of the normal cerebellum.
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PMC10631132
Medium changes were performed every 2–3 days.
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PMC11470381
Calculate the distance of the half-center points of each of the above-calculated half-ellipses from the ellipse’s centroid in the preceding frame in the trajectory.
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PMC11468365
The left side shows the mean for the first regression target task (synergy), while the right side shows the mean for the second regression target task (sensitivity) The mean difference between the input features and output features of the attention mechanism is shown.
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PMC11422150
The examination was done before induction of SCI, on the day of transplantation (day 3), and once weekly thereafter for 4 weeks.
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PMC11078693
Alternatives: Any confocal microscope can be used for imaging.
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PMC11638288
For instance, in patients with immune-related RPL, the expression of NKp46 on decidual NK cells is decreased.
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PMC8584319
In addition, AZD8055 down-regulated the phosphorylation of 4E-BP1, and the AZD8055-mediated up-regulation of ERK1/2 and p38 phosphorylation was independent of 4E-BP1 phosphorylation status.
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PMC11463018
Besides, much weaker inhibition of HDAC7, 8, 11 was observed.
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PMC10965315
Combining N‐acetyl cysteine (NAC) with harmaline at concentrations of 300 μM resulted in enhanced viability of A2780 cells 24 h after treatment, as compared to each group individually with the same concentrations.
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PMC11683240
A typical excitation beam power of ∼0.8 μw and a depletion beam power of ∼1.3 mW were used during image acquisition.
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PMC11547917
A voucher specimen (CBG-AcL-01) has been identified by a botanist and the plant was stored in the Herbarium of the Faculty of Chemistry, Biology, Geography from Timișoara, Romania.
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PMC11470999
Our results identified that PF can directly bind to CIP2A, promoting the interaction between CIP2A and VHL, thereby facilitating CIP2A degradation.
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PMC10926885
NDE1, PAFAH1B1 and DCTN1 peptide chain structures were predicted, and binding sites for the interactions were found (Figure 4C,D).
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PMC9429973
CK2 and BCL2 inhibition was obtained with Sil and Ven, respectively and with CK2 gene silencing through the generation of anti-CK2 shRNA IPTG-inducible MCL cell clones.
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PMC10093184
The sex determination using amelogenin analysis was in accordance with the patient history.
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PMC9429973
Two of the 3 pts who did not achieved MRD negativity were later found to have a NUP214::ABL1 fusion.
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PMC11644761
In differentiated Caco2 cells, a model of the intestinal epithelial barrier, pterostilbene has demonstrated no toxicity and the ability to reverse DNA demethylation induced by environmental toxins like arsenic.
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PMC10079526
A Graphic visualization of in vivo experimental time line.
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PMC11755519
A total of 78 articles were found.
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PMC10048572
To test hypotheses about differences in distributions of categorical features in the comparison groups, the analysis of contingency tables was used.
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PMC11755519
In addition, they increase the expansion of myeloid-derived suppressor cells and stimulate the polarization of macrophages towards the tumor-promoting M2 phase, which enhances the promotion of the development of the niche/tumor microenvironment (Figure 5, Table 2).
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PMC11734514
For detection, 20 μL of each amplified cDNA solution was mixed with 5 μL Fermentas LD 6x (Thermo Fisher Scientific, MA, USA) and subjected to gel electrophoresis.
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PMC11588085
In normoxia, cell survival rates were not significantly different between cells with sgXIST and cells with sgCtl; however, under hypoxia, OVCAR3-KRAB cells with sgXIST showed significantly higher survival rates (Fig. 5E).
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PMC11320834
The discarded anonymous pathological material, which was deidentified and banked, was obtained at the Tumor Retrieval Core Facility at the Cancer Institute of New Jersey.
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PMC11300639
Data are presented as the mean ± SEM of three replicates. ***,
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PMC9429973
Aims: We herein hypothesized that sialofucosylation participates in platelet recruitment on the surface of MM cells via P-selectin, forming a “cloak” that protects tumor cells from NK-mediated cytotoxicity.
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PMC11392912
DCFDA- 2′,7′, dichlorofluorescin diacetate; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HC, healthy control; IL, interleukin; M, Molecular weight marker; NC, non-specific miRNA pool control; RAFLS, rheumatoid arthritis fibroblast like synoviocyte; ROS, reactive oxygen species; TNF-α, tumor necrosis factor-α; UT, U...
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PMC11742431
All cell lines were grown in a medium containing 10% fetal bovine serum (Invitrogen) and 1% antibiotics (penicillin/streptomycin/amphotericin B; Solarbio) and placed in an incubator at 37°C with 5% CO2.
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PMC11585565
Western blot analysis results for wild-type and mutant CNNM4 proteins at 24- and 48-hours post-transfection, with GAPDH serving as a loading control. (
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PMC9429973
HSCT pts not receiving GCV were also included as controls (C).
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PMC11474209
There are 2.4 billion people in India without adequate sanitation.
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PMC10291556
Attempts to conjugate DCF directly to the Pt center resulted in a Pt complex that was unstable, so we used an ethylenediamine linker to conjugate bulky ligands to the Pt center.
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PMC11674834
Media was centrifuged at 15,000× g for 10 min, and the supernatant was used to separate and quantitate all substrates and their acetylated products by high-performance liquid chromatography (HPLC), as described below.
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PMC11750161
The results were calculated from the ratio of fluorescence at 665 and 620 nm and expressed as Delta F% (cAMP inhibition) according to the following equation: Delta F% = (standard or sample ratio − mock transfection) 100 / mock transfection.
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PMC11345828
NaHCO3, water, and brine.
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PMC8584666
These observations suggested that GPI-80 might diffuse and thereby play a role in the formation of tumor microenvironment.
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PMC9424261
Therefore, we confirmed from both in vivo and in vitro experiments that CA acts on MDM2 through HERPUD1 to reduce GSS, and then inhibit the synthesis of GSH to increase ferroptosis.
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PMC10419319
A flow cytometric analysis of apoptosis was performed to evaluate the apoptosis-inducing effects of isoalantolactone.
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PMC9693627
The specificity of the activity of complex IV was checked by addition of 2 μL of 1M potassium cyanide (KCN).
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PMC9429973
For each patient the available plasma with the highest titers of neutralizing antibodies and matching blood type was administered.
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PMC11528603
In addition to the anticancer activity, the water fraction of the S. affinis fruits was proved to be a robust antioxidant regimen in the Drosophila model.
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PMC10565698
B and C. Evaluation of knockdown efficiency of circUSP10 in HCCLM3 and BEL-7407 cell lines.
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PMC10291556
The glucose amount consumed by the non-treated control was taken at 100%.
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PMC11597291
Then, cellular apoptosis was determined with the FITC Annexin V Apoptosis staining method according to a standard protocol .
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PMC11204465
As early as 1968, Holker et al. suggested a possible biological pathway for STC.
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PMC11521786
Furthermore, the antitumor effect observed in mice immunized with both murine and human ErbB3 receptors as antigens and subsequently challenged with a metastatic tumor resistant to an anti-EGFR MAb suggests the potential of vaccination with the Mv-HER3 candidate in the context of HER3-overexpressing carcinomas that hav...
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PMC11129910
RAB25 expression brings down HIF-1α levels quite significantly in RAO-3 and RAO-4.
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PMC6034753
GST was negative control in (A) and (B) in pull down assays.
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PMC11216402
CTCF loop predictions shown in Figures 3C, 6D, and 6E use LE model predictions (Xi and Beer 2021) using CTCF ChIP-seq in endoderm (Luo et al. 2023).
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PMC11453018
Indeed, the transcription of LMNB1 upon P300/CBP knockdown mirrored those observed with EWS::FLI1 knockdown (Fig. 6C).
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PMC11632064
Densitometric values were corrected for cell counts.
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PMC11803149
FMO: fluorescence minus one.
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PMC11190538
The remains of C-PC in T3 and T4 showed high stability and low degradation, possibly due to the encapsulation by phytosomes, which gives high protection.
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PMC6442998
The respective IC50 at each time-point for both cell lines.
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PMC11697189
Fig. 2Biological characteristics and consensus clustering analysis of HSPs in ccRCC. (
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PMC11802929
These cells were then projected onto a gene expression UMAP (GEX-UMAP) based on the scRNAseq data (Fig. 4a).
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PMC11248911
Yellow crystals, mp = 130–1 °C, yield (88%).
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PMC11666785
D The corresponding intensity plots along lines L1 and L2 passing through actin and tubulin structures are shown.
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PMC11795610
Activation of TRPV4 induced by heat and chemical agonists can accelerate skin barrier regeneration.
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PMC9429973
of Oncology and Hematology, Hospital Barmherzige Brüder, Regensburg; Psycho-Oncology, Hospital Garmisch-Partenkirchen, Garmisch-Partenkirchen, Germany Background: Clonal hematopoiesis (CH), the outgrowth of hematopoietic stem cells and their progeny with somatically acquired gene mutations, is a common phenomenon in el...
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PMC11683130
Parakeratosis, the persistence of nuclei in the stratum corneum, is one of the histopathological features of psoriasis (144) and is related to excessive proliferation and poor differentiation of keratinocytes (145).
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PMC9429973
Ibrutinib, as a single agent, has demonstrated limited activity in DLBCL with mutant MYD88 and wildtype CD79.
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PMC11323699
Concomitantly, ALX Oncology in August 2023 announced an end to its ASPEN-02 and ASPEN-05 programs, which were evaluating the efficacy of its CD47 inhibitor evorpacept in myelodysplastic syndrome and acute myeloid leukaemia.
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PMC11758416
The number of L cells for a 10:1 (Effector:Target) ratio would then be 5E3 L cells per well.
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PMC5673955
during 40 days of cultivation (Fig. 7F).
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PMC8916024
Therefore, Flavobacterium and Geobacter in the snail gut likely originate from the sediment.
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PMC5386478
We next measured the expression of TGM2-v1 transcript in MSTO211-H cells cultured in normoxic or hypoxic conditions.
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PMC7917457
For in vivo assessment of the oncolytic potency of VALO-D102 and PeptiCRAd-1, 6-week-old immunodeficient female athymic nude-Foxn1-nu mice were injected in the right flank with 5 × 10 A549 cells and were treated triweekly starting at day 11 post-tumor implantation with 1 × 10 VPs of VALO-D102, PeptiCRAd-1, Ad5/3luc1, o...
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PMC10900886
Poliovirus productively infects dendritic cells (DCs) and macrophages in vitro (human peripheral blood mononuclear cells [PBMC]) and in vivo (non-human primates) (22, 23).
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PMC9429973
At the same time, some studies have proved that there is a significant difference in the expression level of WT1 mRNA between MDS and hemocytopenia caused by other reasons.
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PMC10218459
Consequently, the combination of CPP and cisplatin or DOX resulted in increased drug uptake in various malignancies such as melanoma, glioblastoma, pancreatic cancer, and prostate cancer .
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PMC8345486
The strengths of associations and correlations were evaluated by the Spearman nonparametric test.
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PMC11451829
Thirteen of 22 eyes (60%) developed pterygium-like lesions after 7 days and progressed through different grades.
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PMC10808409
Using differential scanning calorimetry (DSC-60 Shimadzu, Tokyo, Japan), thermograms of ferulic acid, TPGS mixed micelles, and blank TPGS mixed micelles were recorded.
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PMC11615218
They likewise exhibit a terminally differentiated phenotype with downregulation of the chemokine receptors CCR7 and CD45RO but upregulation of CD45RA .
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PMC11402217
ER staining in 143B cells treated with XD23.
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PMC7334607
The y axis of all the point-range plots has μM units, except Cyclo, where the unit is percent of chemically activated 4-hydroxycyclophosphamide solution by volume.
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PMC11218145
Cells seeded on 24-mm glass coverslips, previously treated as indicated in the figure legends, were loaded with 20 nM tetramethylrhodamine, methyl ester (TMRM) for 30 min at 37 °C.
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PMC10994876
3Real-time PCR analysis of samples obtained from OE-YAP5SA and control EPO-CHO cells.
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PMC10878518
All experimental methods were conducted in accordance with relevant guidelines and regulations.
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PMC8303372
Moreover, the absence of toxicity of conveyed 200 µmol/L GA formulation is verified by the high similarity of its resistance time course with that of the two controls, for the entire duration of the recordings.
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PMC11551844
AuNPs with low zeta potentials favoured the enhanced permeability and retention (EPR) effect resulting in enhanced internalization of AuNPs by cancer cells, which have positively charged surfaces.
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PMC2118063
Targets of transcriptional regulation by IRF8 and its partners have been studied in macrophages, granulocytic cells, and DCs.
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PMC11543853
Enteroviruses attach to specific cellular receptors; however, they can utilize various types of endocytosis for cell entry.
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PMC11762280
We found that inhibiting ZBP1-mediated PANoptosis by ZBP1 knockout reduced UVB-induced keratinocyte death and epidermal thickening.
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PMC11342785
For zoomed in insets of OptoTPPP C-CORE, scale bars represent 5 μm.
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PMC9268620
In fact, it has been shown that the early signal for the initiation of apoptosis by various stimuli was due to elevation in cytosolic Ca .
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PMC9429973
For follow-up experiments, we established a CALR mutant-specific antibody for use in high-content immunofluorescence imaging.
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PMC10936243
There were five different items (see Table 1) developed in the second part of the questionnaire to measure respondents’ attitudes towards cat welfare (Figure 2).
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PMC11656048
The in vivo anti-tumor effect of shikonin still remains to be verified, and relevant research should be carried out as soon as possible.
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PMC11240448
These vectors built in the phosphoproteomic data space are termed the STVonc and STVL-B, respectively .
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PMC6643347
Assessment of the efficacy of SBF-HS under conditions of single-cycle infection (TZM-bl cells and five HIV pseudoviruses).
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PMC7081114
The differences between groups were compared using Student’s t-test.
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