OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	We found a heterozygous missense variant p.Thr686Met, predicted to impair splicing, and reported as likely pathogenic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "a", "heterozygous"...
PMC10747160	This is in contrast to GLG-3A inhibition tests with HIV-1 pseudovirus, whereby removing the crosslinking ability of Griffithsin diminished its antiviral activity by approximately 100-to-1000-fold .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	We explored the relationship between genotype and phenotype in 105 children with FA genotyping results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "explored", "the", "relationship", "between", "genotype", ...
PMC9429973	Tisagenlecleucel provided high rates of remission (>80%) in children and young adults with R/R B-ALL in ELIANA, with 62% of responders remaining relapse-free at 24 mo (Grupp et al, Blood, 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10759659	Based on the mRNA transcription data, we next estimated the activity of stromal and immune cells present in tumour tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "th...
PMC11697703	I, J, M, and N) ANOVA-Tukey, p values are presented as follows; ∗p < 0.05, ∗∗p < 0.01.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC2193049	Constructs II, III, and IV were obtained by annealing complementary synthetic oligonucleotides encoding the MAGE-3–derived peptide fragments MAGE-3271–279, MAGE-3256–279, and MAGE-3271–285, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476666	Untreated control cells were incubated in the presence of 50 µM Verapamil (Thermo Fisher Scientific), a known ABC transporter inhibitor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Untreat...
PMC10958426	The scWGS libraries and bulk DNA-seq libraries were sequenced on Illumina NovaSeq6000 system, setting with paired-end 150bp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scWGS", "libraries", "and", "bu...
PMC9672323	The graphs show the mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "graphs", "show", "the", "mean", "±", "SD", "." ] } ]
PMC11676674	Few studies have reported the cytotoxic effects of some C. monspeliensis extracts in various cell lines, with different findings based on the cell types used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10656496	Pediatric sarcomas, particularly osteosarcomas, are known for having considerable rearrangements associated with genomic instability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pediatric", "sarcomas", ",", "particularly", "osteosarcomas"...
PMC11683240	In the infant mouse model of severe pertussis, α1AT expression was reduced upon infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "infant", "mouse", "model", "of", "severe", ...
PMC11721295	Slides were deparaffinized and rehydrated and then washed in deionized water for 5 minutes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Slides", "were", "deparaffinized", "and", "rehydrated", "and", "then",...
PMC11319300	Overexpression of MYEOV has been associated with poor prognosis in different cancers (Janssen et al., 2002a; Janssen et al., 2002b; Leyden et al., 2006; Moss et al., 2006; Moreaux et al., 2010; Takita et al., 2011; Fang et al., 2019; Liang et al., 2020; Shen et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301242	GSEA results of the gene expression profiles in AML patients carrying circular MYC amplification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GSEA", "results", "of", "the", "gene", "expression", "profiles", ...
PMC11615743	This decrease in the signal gain compared with that of the dual‐aptamer‐based logic gate could be attributed to the challenges associated with simultaneously targeting the proteins of interest via three aptamers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754784	e AFM imaging of cage-Nb.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "e", "AFM", "imaging", "of", "cage-Nb", "." ] } ]
PMC6889484	Viral supernatants were collected every 2 to 3 days, and p24 CA was measured by ELISA up to 28 days post-infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Viral", "sup...
PMC11726848	Modern radiotherapy utilizes a broad range of sources of ionizing radiation, both low-dose-rate (LDR) and high-dose-rate (HDR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Modern", "ra...
PMC9429973	Median follow-up was 545 (14-3190) days for CML and 210 (26-2933) days for Ph+ALL patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median"...
PMC10854447	C21H15N5O: C, 71.38; H, 4.28; N, 19.82.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C21H15N5O", ":", "C", ",", "71.38", ";", "H", ",", "4.28", ";",...
PMC11755467	The error bars represent the s.d.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "error", "bars", "represent", "the", "s.d", "." ] } ]
PMC11411131	A TrxR1-green fluorescent protein (GFP) cDNA construct was generated by fusing GFP, which is a compact protein suitable for fusion protein expression, to the carboxyl terminus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11632064	Immunoblotting for PARP in protein extracts from MeWo-Rho-0 cells treated with DMSO 0.1%, BI 6727, or doxorubicin for 72 h. FL, full-length. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11648299	To each patient with DD, ten age-, sex- and municipality-matched controls were randomly drawn from the Swedish population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "each", "patient", ...
PMC11594588	This leads to pathological cell hypertrophy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "leads", "to", "pathological", "cell", "hypertrophy", "." ] } ]
PMC11224020	The specificity of the antibody to CCR7 was verified using Ccr7-knockout DCs (Extended Data Fig. 1c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "specificity", "of", "the", "ant...
PMC11588008	There are a lot of research about GSH metabolism in liver disease, while there is few research about GSH metabolism in granulosa cells, especially in granulosa cell injury.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240052	Subsequently, the absorbance of each well was measured at 450 nm using a microplate reader.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "absorbance", "of", "each",...
PMC5941560	Sequencing data, variant data, and the code used for analysis are all publicly available (see “Availability of supporting data” section).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11731161	Therefore, our study aims to investigate the role of XPO1 degradation in the anti-myeloma effects of SEL and to further elucidate the molecular mechanisms by which SEL induces XPO1 degradation in MM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11082662	Subsequently, the disrupted cells were then cultured in medium devoid of FBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "disrupted", "cells", "were", "then", "cultured"...
PMC11802929	Mean values +/- SEM are utilized for violin plots.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mean", "values", "+", "/-", "SEM", "are", "utilized", "for", "violin", "plots", "." ] ...
PMC11413393	d Cell line growth curve of RCC243 cells engineered to overexpress PRMT1 isoforms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Cell", "line", "growth", "curve", "of", "RCC243", "cells", ...
PMC11786156	An adhesion assay was performed using HBL-2 cells in a recombinant human LFA1/(CD11a/CD18)-coated 96-well microplate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "adhesion", "assay", "was", "performed", "using", ...
PMC5600151	Sanyakamdhorn et al. described a thorough investigation of the intramolecular interaction of DOX and tamoxifen, and their respective analogs, with dendrimers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sanyaka...
PMC11224020	We hypothesized that such shape change might further trigger CCR7 expression, thereby endowing DCs with the full capacity to reach their next destination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11545868	Alshehri, M.M., et al. and Hsu, A., et al. suggested daidzein has also been investigated for its potential role in reducing the risk of breast and prostate cancer by increasing the expression of Bax in MCF-7 and PC3 prostate cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	In the Mecp2 floxed allele, Mecp2 exons 2 and 3 were flanked with loxp sites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "Mecp2", "floxed", "allele", ",", "M...
PMC11530949	Using UV-Vis-NIR and FTIR spectrophotometers, the optical characteristics of the produced coatings were examined in the wavelength ranges of 0.3–2.5 μm and 2.5–20 μm, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10858941	A Western-blot of HIF-1α and p62/SQSTM1 from A-172 and U-251 MG cells grown in normoxia or hypoxia for 48 h (untreated or treated with NNC for the last 8 h).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11001582	Expression of patient-length repeats did not lead to overt gliosis or TDP-43 mis-localization over 12 months, nor did it lead to cortical neuronal loss.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11495567	To label the cells, 5 μL of FITC reagent and 1 μL PI (1 mg/ml) were added and gently mixed into the suspension and incubated for 15 min while shielding from light.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11412721	ACKR4 is a prognostic factor in Burkitt lymphomas but not in diffuse large B-cell lymphomas.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ACKR4", "is", "a", "prognostic", "factor", "in", "Burkitt",...
PMC10850553	Figure 3Potential role of mTOR pathway in the transcriptional induction of C5ar1 in intracranial aneurysm lesions. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "3Potential", "role", "of", "mTOR", ...
PMC11607638	SKR‐KillerRed‐CHO‐K1 cells were fixed in 4% paraformaldehyde, counterstained with nuclear dye DAPI, and imaged in a laser scanning confocal microscope (Zeiss LSM 710) under objective 63×/1.40 oil: KillerRed: λ ex, 561 nm, λ em 618 nm; DAPI: λ ex 405 nm, λ em 477 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806818	Recent research advances have highlighted the potential applications of nanozyme-based aptasensors for tumor biomarker detection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "research", "advances", "have", "highlighted", "the", ...
PMC11377827	We generated mutations of the putative catalytic triad of USP43 (nucleophilic cysteine 110 and proton acceptor histidine 668) based on the Alphafold predictions (Jumper et al, 2021) (Fig. 4C,D), and used a biotinylated DUB probe (Biotin-ANP-Ub-PA) that covalently binds the active cysteine to investigate DUB activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11588008	Exosomes are related therapies of many diseases, such as polycystic ovary syndrome and POI .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Exosomes", "are", "related", "therapies", "of", "many", "di...
PMC9429973	We then used genomic approaches (whole genome sequencing and transcriptomic analyses) to understand the PIs resistance mechanisms acquired by MM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC9429973	Thirty-five patients had no i-iii) factors (27%), symptoms only were in 49 patients (38%), one CF without and with symptoms was noticed in 9 (7%) and 22 (17%) patients, respectively, and 15 (11%) patients had 2 CF +/- symptoms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A VOC was identified using ICD diagnosis codes in hospitalization and ER visit claims for acute pain crisis, acute chest syndrome, priapism, and splenic sequestration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453018	To capture immediate and highly sensitive transcriptional responses while avoiding secondary targets, RNA-Seq was performed at 4 h post-treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "capture", "immediate",...
PMC11574271	We then studied whether the forced MiR-659-3p expression affects tumor metastasis in mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then", "studied", "whether", "the", "forced", "MiR-65...
PMC11640419	Over the past decade, our research group, in collaboration with other groups, has demonstrated that natural and synthetic fatty dienoic acids containing a 1Z,5Z-diene fragment in their structure exhibit a diverse range of biological activities, including antitumor, antibacterial, antiviral, and other effects (Scheme 1)...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767793	The UV–Vis absorbance spectrum for AuNPs typically showed an SPR peak near λmax ≈ 520 nm, and this value could vary from slightly below 520 nm to more than 535 nm, depending on the size of the AuNPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11585254	A major finding from our study is that β-arrestins mediate only one of its three canonical functions at CXCR5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "major", "finding", "from", ...
PMC11337594	Melanoma has become a rapidly growing cancer type in developed countries.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Melanoma", "has", "become", "a", "rapidly", "growing", "cancer", "type", "in", "devel...
PMC7185206	Regression modeling was performed for each cancer subset using the base R!	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regression", "modeling", "was", "performed", "for", "each", "cancer", "subset", ...
PMC10055960	CNMR (151 MHz, Benzene-d6): δ (ppm) = 163.4 (s, C1b), 151.1 (s, C2b), 149.9 (s, C7b), 133.3 (s, C9b), 133.1 (s, C8b), 130.3 (s, C3b), 125.4 (s, C4b), 123.5 (s, C5b), 54.8 (s, C10b), 47.8 (s, C11b), 31.5 (s, C12b), 21.4 (s, C6b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803149	We performed scRNA-seq analysis using pooled OT-I-TCR-T cells collected from these mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "performed", "scRNA-seq", "analysis", "using", "pooled", "OT-I-TCR-T", "cells", ...
PMC11763111	Irradiated donor CAR-T cells were mixed with fourfold alloreactive PBMC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Irradiated", "donor", "CAR-T", "cells", "were", "mixed", "with", "fourfold", "alloreactive"...
PMC9646302	LAPTM5 contains a ubiquitin interaction region, which interacts with E3 ubiquitin ligases and plays important roles in ubiquitination .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LAPTM5", "contains", "a", "ubiqui...
PMC9429973	However, evidence collating the impact of non-pharmacological interventions is sparse.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "evidence", "collating", "the", "impact", "of", "non-pharmacological", "inte...
PMC9596868	Quercetin exhibits reduced cytotoxicity towards normal cells and its co-treatment with several chemotherapeutic drugs and compounds augments anticancer treatment strategies , , , , .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11530949	Subsequently, the fluorescence intensity at 530 nm was measured using a microplate reader (Awareness Microplate Reader (Stat Fax 4200), USA) (34).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711063	These studies were also supported by the ÚNKP‐21‐3 New National Excellence program of the Ministry for Innovation and Technology (ML).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "stu...
PMC11666785	It is clear that high-resolution images can be reconstructed using all fortunate molecules that blink for τ ≥ 60ms and appear in 2-4 frames.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11507371	The Nrf2 localisation in A431 cells only showed a minor upward trend in nuclear translocation with increasing durations of CAP treatment (Figure 5A), although measurements of protein levels revealed an elevated Nrf2 abundance in CAP-treated A431 cells (+48%) (Figure 6A).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676169	These cells were maintained in DMEM containing 10% fetal bovine serum (FBS) and 0.05 mg/mL penicillin/streptomycin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "cells", "were", "maintai...
PMC9429973	S. Troester, J. Schmoellerl, T. Eder, G. Manhart, G. Winter, J. Zuber, F. Grebien Institute for Medical Biochemistry, University for Veterinary Medicine Vienna; Research Institute of Molecular Pathology (IMP); Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria Background:...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	LAVA-051 is administered by IV infusion over 2 hours twice a week.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LAVA-051", "is", "administered", "by", "IV", "infusion", "over", "2", "hours", ...
PMC11320834	A phase I study was performed to determine the safety, tolerability, and maximum tolerated dose (MTD) of orally administered olaparib in combination with topotecan in patients with advanced solid tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Sil +Ven combination increased MCL cell apoptosis, as judged by the augmented frequency of Annexin V positive cells and expression of cleaved PARP protein, and JC-10 mitochondrial membrane depolarization, with respect to the single treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This association was significant by the Log Rank test (p=0.02).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "association", "was", "significant", "by", "the", "Log", "Rank", "test", ...
PMC11790599	The scale bar is 25 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scale", "bar", "is", "25", "μm", ".", "(" ] } ]
PMC10329237	There is no clear information on the pathophysiological mechanisms underlying IPF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "no", "clear", "information", "on", "the", "pathophysiological", "mechanisms"...
PMC10955424	In contrast, most of the cirrhosis ascites (3 out of 4 ascites) failed to promote platinum chemoresistance to OC cells (Fig. 1C, E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	Our data shows that the E191 residue responsible for the ability of HopAM1 to catalyze the v2-cADPR reaction was necessary for arbovirus rescue in LD652 cells (Fig 3C–3F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9341513	The model included three different species of bridge-forming protein: a general “active binder,” and two types of repressive binders (this is an extension of the scheme in Buckle et al. which only included active proteins).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291697	P proband, C control.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "proband", ",", "C", "control", "." ] } ]
PMC11733919	Effects of drugs and nanoplatform on nonsenescent cells and MNP@CD26@17D stimulated necrosis-based senolysis, necrotic morphotype of cell death, in senescent normal and cancer cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8097906	Our primary aim was to identify potential plant-derived substances which can reduce the RMA migration, invasion, and anchorage-independent colony formation capacity in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11401358	Data represent the mean ± SD. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represent", "the", "mean", "±", "SD", ".", "(" ] } ]
PMC11695623	7Relationship between DCUN1D5 expression and tumor immune cell infiltration. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "7Relationship", "between", "DCUN1D5", "expression", "and", "tumor", "immune", "cell", "infiltration", ...
PMC11759751	For patients with newly diagnosed DLBCL and other aggressive B-NHL, rituximab combined with anthracycline-based chemotherapy (R-CHOP) is the standard first-line treatment for most patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711347	The yield of the synthesized Ni(II)ProDtc complex was 21.90%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "yield", "of", "the", "synthesized", "Ni(II)ProDtc", "complex", "was", "21.90", "%", ...
PMC6160470	Moreover, DAC-2Amide was comparable, but slightly less active than cyclosporine A (CsA), and much less potent than PSC-833 (Fig. 2b,c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803210	In MCF-7 cells treated with Nar (10 µM), expression of ER-associated gene SDF1 was significantly higher compared to E2-induced levels (unpublished results).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	FX was 19%.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "FX", "was", "19", "%", "." ] } ]
PMC9031474	However, the contribution of TRPA1 activation to the anticancer activity of drimane and coloratane sesquiterpenoids needs to be evaluated in greater detail.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...
PMC11473843	Relative quantification of colony forming capacity of HBEC3-FAK KO cells previously transduced as indicated; n = 3. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "quantification", "of", ...
PMC11388384	Distribution of SHH among diffusive populations across a range of SCUBE1 concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Distribution", "of", "SHH", "among", "diffusive", "populations", "across", "a", ...
PMC11731614	The DRG transcriptome is substantially altered in PDN (George, 2022), resulting in hyperexcitability of the nociceptive neurons that drive neuropathic pain (Jayaraj, 2018, George, 2022) and presenting a possible druggable system for future therapeutics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The study utilizes a hybrid accelerated titration with single pt cohorts and a Bayesian optimal interval design to assess 9 potential dosing cohorts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11733919	However, it is unknown whether CD26 levels are also elevated in drug-induced senescent cancer cells and if CD26 can be targeted during chemotherapy-associated senescence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11743316	Because of its speed and sensitivity, mitochondrial proteomics has been widely utilized for protein detection and quantification in the mitochondrial proteome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Because", "o...
PMC10777969	Both compounds exhibit similar cytotoxicity for cancer cells, but their mechanism of action seems to be drastically different.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "compounds", "exhibit", "s...
PMC9429973	F. Tiso, A. O. de Graaf, L. I. Kroeze, B. A. van der Reijden, S. M. C. Langemeijer, K. M. Hebeda, J. H. Jansen Department of Laboratory Medicine, Laboratory of Hematology; Department of Pathology; Department of Hematology, Radboudumc, Nijmegen, Netherlands Background: The hypomethylating agent Decitabine is used mainly...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

We found a heterozygous missense variant p.Thr686Met, predicted to impair splicing, and reported as likely pathogenic.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "a", "heterozygous"...

PMC10747160

This is in contrast to GLG-3A inhibition tests with HIV-1 pseudovirus, whereby removing the crosslinking ability of Griffithsin diminished its antiviral activity by approximately 100-to-1000-fold .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

We explored the relationship between genotype and phenotype in 105 children with FA genotyping results.

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PMC9429973

Tisagenlecleucel provided high rates of remission (>80%) in children and young adults with R/R B-ALL in ELIANA, with 62% of responders remaining relapse-free at 24 mo (Grupp et al, Blood, 2018).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10759659

Based on the mRNA transcription data, we next estimated the activity of stromal and immune cells present in tumour tissues.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "th...

PMC11697703

I, J, M, and N) ANOVA-Tukey, p values are presented as follows; ∗p < 0.05, ∗∗p < 0.01.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC2193049

Constructs II, III, and IV were obtained by annealing complementary synthetic oligonucleotides encoding the MAGE-3–derived peptide fragments MAGE-3271–279, MAGE-3256–279, and MAGE-3271–285, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11476666

Untreated control cells were incubated in the presence of 50 µM Verapamil (Thermo Fisher Scientific), a known ABC transporter inhibitor.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Untreat...

PMC10958426

The scWGS libraries and bulk DNA-seq libraries were sequenced on Illumina NovaSeq6000 system, setting with paired-end 150bp.

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PMC9672323

The graphs show the mean ± SD.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "graphs", "show", "the", "mean", "±", "SD", "." ] } ]

PMC11676674

Few studies have reported the cytotoxic effects of some C. monspeliensis extracts in various cell lines, with different findings based on the cell types used.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC10656496

Pediatric sarcomas, particularly osteosarcomas, are known for having considerable rearrangements associated with genomic instability.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pediatric", "sarcomas", ",", "particularly", "osteosarcomas"...

PMC11683240

In the infant mouse model of severe pertussis, α1AT expression was reduced upon infection.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "infant", "mouse", "model", "of", "severe", ...

PMC11721295

Slides were deparaffinized and rehydrated and then washed in deionized water for 5 minutes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Slides", "were", "deparaffinized", "and", "rehydrated", "and", "then",...

PMC11319300

Overexpression of MYEOV has been associated with poor prognosis in different cancers (Janssen et al., 2002a; Janssen et al., 2002b; Leyden et al., 2006; Moss et al., 2006; Moreaux et al., 2010; Takita et al., 2011; Fang et al., 2019; Liang et al., 2020; Shen et al., 2021).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11301242

GSEA results of the gene expression profiles in AML patients carrying circular MYC amplification.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GSEA", "results", "of", "the", "gene", "expression", "profiles", ...

PMC11615743

This decrease in the signal gain compared with that of the dual‐aptamer‐based logic gate could be attributed to the challenges associated with simultaneously targeting the proteins of interest via three aptamers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11754784

e AFM imaging of cage-Nb.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "e", "AFM", "imaging", "of", "cage-Nb", "." ] } ]

PMC6889484

Viral supernatants were collected every 2 to 3 days, and p24 CA was measured by ELISA up to 28 days post-infection.

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PMC11726848

Modern radiotherapy utilizes a broad range of sources of ionizing radiation, both low-dose-rate (LDR) and high-dose-rate (HDR).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Modern", "ra...

PMC9429973

Median follow-up was 545 (14-3190) days for CML and 210 (26-2933) days for Ph+ALL patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median"...

PMC10854447

C21H15N5O: C, 71.38; H, 4.28; N, 19.82.

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PMC11755467

The error bars represent the s.d.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "error", "bars", "represent", "the", "s.d", "." ] } ]

PMC11411131

A TrxR1-green fluorescent protein (GFP) cDNA construct was generated by fusing GFP, which is a compact protein suitable for fusion protein expression, to the carboxyl terminus.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11632064

Immunoblotting for PARP in protein extracts from MeWo-Rho-0 cells treated with DMSO 0.1%, BI 6727, or doxorubicin for 72 h. FL, full-length. (

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PMC11648299

To each patient with DD, ten age-, sex- and municipality-matched controls were randomly drawn from the Swedish population.

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PMC11594588

This leads to pathological cell hypertrophy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "leads", "to", "pathological", "cell", "hypertrophy", "." ] } ]

PMC11224020

The specificity of the antibody to CCR7 was verified using Ccr7-knockout DCs (Extended Data Fig. 1c).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "specificity", "of", "the", "ant...

PMC11588008

There are a lot of research about GSH metabolism in liver disease, while there is few research about GSH metabolism in granulosa cells, especially in granulosa cell injury.

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PMC11240052

Subsequently, the absorbance of each well was measured at 450 nm using a microplate reader.

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PMC5941560

Sequencing data, variant data, and the code used for analysis are all publicly available (see “Availability of supporting data” section).

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PMC11731161

Therefore, our study aims to investigate the role of XPO1 degradation in the anti-myeloma effects of SEL and to further elucidate the molecular mechanisms by which SEL induces XPO1 degradation in MM cells.

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PMC11082662

Subsequently, the disrupted cells were then cultured in medium devoid of FBS.

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PMC11802929

Mean values +/- SEM are utilized for violin plots.

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PMC11413393

d Cell line growth curve of RCC243 cells engineered to overexpress PRMT1 isoforms.

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PMC11786156

An adhesion assay was performed using HBL-2 cells in a recombinant human LFA1/(CD11a/CD18)-coated 96-well microplate.

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PMC5600151

Sanyakamdhorn et al. described a thorough investigation of the intramolecular interaction of DOX and tamoxifen, and their respective analogs, with dendrimers .

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PMC11224020

We hypothesized that such shape change might further trigger CCR7 expression, thereby endowing DCs with the full capacity to reach their next destination.

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PMC11545868

Alshehri, M.M., et al. and Hsu, A., et al. suggested daidzein has also been investigated for its potential role in reducing the risk of breast and prostate cancer by increasing the expression of Bax in MCF-7 and PC3 prostate cancer cells .

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PMC11095939

In the Mecp2 floxed allele, Mecp2 exons 2 and 3 were flanked with loxp sites.

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PMC11530949

Using UV-Vis-NIR and FTIR spectrophotometers, the optical characteristics of the produced coatings were examined in the wavelength ranges of 0.3–2.5 μm and 2.5–20 μm, respectively.

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PMC10858941

A Western-blot of HIF-1α and p62/SQSTM1 from A-172 and U-251 MG cells grown in normoxia or hypoxia for 48 h (untreated or treated with NNC for the last 8 h).

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PMC11001582

Expression of patient-length repeats did not lead to overt gliosis or TDP-43 mis-localization over 12 months, nor did it lead to cortical neuronal loss.

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PMC11495567

To label the cells, 5 μL of FITC reagent and 1 μL PI (1 mg/ml) were added and gently mixed into the suspension and incubated for 15 min while shielding from light.

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PMC11412721

ACKR4 is a prognostic factor in Burkitt lymphomas but not in diffuse large B-cell lymphomas.

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PMC10850553

Figure 3Potential role of mTOR pathway in the transcriptional induction of C5ar1 in intracranial aneurysm lesions. (

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PMC11607638

SKR‐KillerRed‐CHO‐K1 cells were fixed in 4% paraformaldehyde, counterstained with nuclear dye DAPI, and imaged in a laser scanning confocal microscope (Zeiss LSM 710) under objective 63×/1.40 oil: KillerRed: λ ex, 561 nm, λ em 618 nm; DAPI: λ ex 405 nm, λ em 477 nm.

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PMC11806818

Recent research advances have highlighted the potential applications of nanozyme-based aptasensors for tumor biomarker detection.

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PMC11377827

We generated mutations of the putative catalytic triad of USP43 (nucleophilic cysteine 110 and proton acceptor histidine 668) based on the Alphafold predictions (Jumper et al, 2021) (Fig. 4C,D), and used a biotinylated DUB probe (Biotin-ANP-Ub-PA) that covalently binds the active cysteine to investigate DUB activity.

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PMC11588008

Exosomes are related therapies of many diseases, such as polycystic ovary syndrome and POI .

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PMC9429973

We then used genomic approaches (whole genome sequencing and transcriptomic analyses) to understand the PIs resistance mechanisms acquired by MM cells.

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PMC9429973

Thirty-five patients had no i-iii) factors (27%), symptoms only were in 49 patients (38%), one CF without and with symptoms was noticed in 9 (7%) and 22 (17%) patients, respectively, and 15 (11%) patients had 2 CF +/- symptoms.

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PMC9429973

A VOC was identified using ICD diagnosis codes in hospitalization and ER visit claims for acute pain crisis, acute chest syndrome, priapism, and splenic sequestration.

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PMC11453018

To capture immediate and highly sensitive transcriptional responses while avoiding secondary targets, RNA-Seq was performed at 4 h post-treatment.

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PMC11574271

We then studied whether the forced MiR-659-3p expression affects tumor metastasis in mice.

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PMC11640419

Over the past decade, our research group, in collaboration with other groups, has demonstrated that natural and synthetic fatty dienoic acids containing a 1Z,5Z-diene fragment in their structure exhibit a diverse range of biological activities, including antitumor, antibacterial, antiviral, and other effects (Scheme 1)...

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PMC11767793

The UV–Vis absorbance spectrum for AuNPs typically showed an SPR peak near λmax ≈ 520 nm, and this value could vary from slightly below 520 nm to more than 535 nm, depending on the size of the AuNPs.

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PMC11585254

A major finding from our study is that β-arrestins mediate only one of its three canonical functions at CXCR5.

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PMC11337594

Melanoma has become a rapidly growing cancer type in developed countries.

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PMC7185206

Regression modeling was performed for each cancer subset using the base R!

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PMC10055960

CNMR (151 MHz, Benzene-d6): δ (ppm) = 163.4 (s, C1b), 151.1 (s, C2b), 149.9 (s, C7b), 133.3 (s, C9b), 133.1 (s, C8b), 130.3 (s, C3b), 125.4 (s, C4b), 123.5 (s, C5b), 54.8 (s, C10b), 47.8 (s, C11b), 31.5 (s, C12b), 21.4 (s, C6b).

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PMC11803149

We performed scRNA-seq analysis using pooled OT-I-TCR-T cells collected from these mice.

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PMC11763111

Irradiated donor CAR-T cells were mixed with fourfold alloreactive PBMC cells.

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PMC9646302

LAPTM5 contains a ubiquitin interaction region, which interacts with E3 ubiquitin ligases and plays important roles in ubiquitination .

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PMC9429973

However, evidence collating the impact of non-pharmacological interventions is sparse.

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PMC9596868

Quercetin exhibits reduced cytotoxicity towards normal cells and its co-treatment with several chemotherapeutic drugs and compounds augments anticancer treatment strategies , , , , .

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PMC11530949

Subsequently, the fluorescence intensity at 530 nm was measured using a microplate reader (Awareness Microplate Reader (Stat Fax 4200), USA) (34).

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PMC11711063

These studies were also supported by the ÚNKP‐21‐3 New National Excellence program of the Ministry for Innovation and Technology (ML).

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PMC11666785

It is clear that high-resolution images can be reconstructed using all fortunate molecules that blink for τ ≥ 60ms and appear in 2-4 frames.

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PMC11507371

The Nrf2 localisation in A431 cells only showed a minor upward trend in nuclear translocation with increasing durations of CAP treatment (Figure 5A), although measurements of protein levels revealed an elevated Nrf2 abundance in CAP-treated A431 cells (+48%) (Figure 6A).

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PMC11676169

These cells were maintained in DMEM containing 10% fetal bovine serum (FBS) and 0.05 mg/mL penicillin/streptomycin.

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PMC9429973

S. Troester, J. Schmoellerl, T. Eder, G. Manhart, G. Winter, J. Zuber, F. Grebien Institute for Medical Biochemistry, University for Veterinary Medicine Vienna; Research Institute of Molecular Pathology (IMP); Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria Background:...

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PMC9429973

LAVA-051 is administered by IV infusion over 2 hours twice a week.

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PMC11320834

A phase I study was performed to determine the safety, tolerability, and maximum tolerated dose (MTD) of orally administered olaparib in combination with topotecan in patients with advanced solid tumors.

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PMC9429973

Sil +Ven combination increased MCL cell apoptosis, as judged by the augmented frequency of Annexin V positive cells and expression of cleaved PARP protein, and JC-10 mitochondrial membrane depolarization, with respect to the single treatments.

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PMC9429973

This association was significant by the Log Rank test (p=0.02).

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PMC11790599

The scale bar is 25 μm. (

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PMC10329237

There is no clear information on the pathophysiological mechanisms underlying IPF.

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PMC10955424

In contrast, most of the cirrhosis ascites (3 out of 4 ascites) failed to promote platinum chemoresistance to OC cells (Fig. 1C, E).

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PMC11098378

Our data shows that the E191 residue responsible for the ability of HopAM1 to catalyze the v2-cADPR reaction was necessary for arbovirus rescue in LD652 cells (Fig 3C–3F).

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PMC9341513

The model included three different species of bridge-forming protein: a general “active binder,” and two types of repressive binders (this is an extension of the scheme in Buckle et al. which only included active proteins).

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PMC11291697

P proband, C control.

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PMC11733919

Effects of drugs and nanoplatform on nonsenescent cells and MNP@CD26@17D stimulated necrosis-based senolysis, necrotic morphotype of cell death, in senescent normal and cancer cells. (

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PMC8097906

Our primary aim was to identify potential plant-derived substances which can reduce the RMA migration, invasion, and anchorage-independent colony formation capacity in vitro.

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PMC11401358

Data represent the mean ± SD. (

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PMC11695623

7Relationship between DCUN1D5 expression and tumor immune cell infiltration. (

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PMC11759751

For patients with newly diagnosed DLBCL and other aggressive B-NHL, rituximab combined with anthracycline-based chemotherapy (R-CHOP) is the standard first-line treatment for most patients.

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PMC11711347

The yield of the synthesized Ni(II)ProDtc complex was 21.90%.

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PMC6160470

Moreover, DAC-2Amide was comparable, but slightly less active than cyclosporine A (CsA), and much less potent than PSC-833 (Fig. 2b,c).

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PMC11803210

In MCF-7 cells treated with Nar (10 µM), expression of ER-associated gene SDF1 was significantly higher compared to E2-induced levels (unpublished results).

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PMC9429973

FX was 19%.

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PMC9031474

However, the contribution of TRPA1 activation to the anticancer activity of drimane and coloratane sesquiterpenoids needs to be evaluated in greater detail.

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PMC11473843

Relative quantification of colony forming capacity of HBEC3-FAK KO cells previously transduced as indicated; n = 3. (

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PMC11388384

Distribution of SHH among diffusive populations across a range of SCUBE1 concentrations.

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PMC11731614

The DRG transcriptome is substantially altered in PDN (George, 2022), resulting in hyperexcitability of the nociceptive neurons that drive neuropathic pain (Jayaraj, 2018, George, 2022) and presenting a possible druggable system for future therapeutics.

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PMC9429973

The study utilizes a hybrid accelerated titration with single pt cohorts and a Bayesian optimal interval design to assess 9 potential dosing cohorts.

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PMC11733919

However, it is unknown whether CD26 levels are also elevated in drug-induced senescent cancer cells and if CD26 can be targeted during chemotherapy-associated senescence.

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PMC11743316

Because of its speed and sensitivity, mitochondrial proteomics has been widely utilized for protein detection and quantification in the mitochondrial proteome.

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PMC10777969

Both compounds exhibit similar cytotoxicity for cancer cells, but their mechanism of action seems to be drastically different.

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PMC9429973

F. Tiso, A. O. de Graaf, L. I. Kroeze, B. A. van der Reijden, S. M. C. Langemeijer, K. M. Hebeda, J. H. Jansen Department of Laboratory Medicine, Laboratory of Hematology; Department of Pathology; Department of Hematology, Radboudumc, Nijmegen, Netherlands Background: The hypomethylating agent Decitabine is used mainly...

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