Datasets:
OTAR3088
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BioData-CellLine_annotated

Dataset card Data Studio Files
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PMC11055323
SS, SS18-SSX1.
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PMC8956657
Rabbit anti-HA (cat# 71-5500) and mouse anti-GAPDH (GA1R) (cat# MA5-15738) were purchased from Invitrogen.
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PMC9429973
Therefore, there remains a need for less toxic and more efficacious lower-intensity AML Tx regimens, especially agents that can be administered in the outpatient setting, which may increase convenience and reduce resource utilization.
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PMC10203589
FGF18 is one of the representative inflammatory markers (48), and in further exploration of the progression of Helicobacter pylori-induced GU or PU to GC.
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PMC7961460
Using the HUMAN PROTEIN ATLAS database, we found a plausible localization in the Golgi apparatus, in line with our findings of involvement in a secretion pathway as supported by the presence of the protein in the culture medium and by confocal microscopy analysis.
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PMC10547921
The biological activity of the compound is reduced by halogenation modifications thailanstatin B (82) and thailanstatin C (83) on epoxides.
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PMC10823017
Despite the pivotal role that c-Myc plays in ccRCC, no primary sequence that identifies the active site could be identified.
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PMC11486946
During the screening, the Z’-factor was calculated for every assay plate from positive- and negative control wells (20 cells in each well) to evaluate the screening quality and images acquired from the plates passing the quality inspection were used in the following analysis (Supplementary Fig. 3a).
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PMC11448304
After being transferred to a PVDF membrane, the membrane was incubated with anti-EGFR and pan anti-2-hydroxyisobutyryllysine (PTM-802, PTM Biolab) antibodies, respectively, overnight.
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PMC9429973
Prognostic factors were evaluated with univariate and multivariate logistic regression (Odds Ratio, OR) and Hazard Ratio (HR) with Cox regression, p value of <0.05 (C 95%) was deemed statistically significant.
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PMC11593713
The highest TOS values were observed for the cells exposed to HCoV-229E and HRV A virus, while the lowest TOS values were observed in the cells exposed to HCoV-OC43.
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PMC8609870
In addition, cell component (CC) changes were mainly concentrated in extracellular matrix, actin cytoskeleton, contractile fiber, contractile fiber part, myofibril, sarcomere, hemoglobin complex, haptoglobin-hemoglobin complex, MHC protein complex and MHC class II protein complex.
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PMC8524093
The main advantage of NHP is the similar pathogenesis and immunological response to CHIKV to that observed in humans.
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PMC11391695
The presence of ACYP2 in both the nucleus and cytoplasm was identified in both normal (LO2) and HCC (SMMC-7721 and BEL-7404) cell lines via dual-localization.
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PMC10237474
The complex also migrated faster under non-reducing SDS-PAGE and was eluted later by analytical SEC compared to the CHO-K1-expressed complex (Fig 7B and 7C).
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PMC11594641
The total protein concentration of the cell lysates and sEVs was measured using a BCA Micro BCA™ Protein Assay Kit (Thermo Fisher Scientific) according to the manufacturer’s instructions.
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PMC11772585
Data are shown as mean ± SEM. *
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PMC9583612
Yet, currently available frameworks do not provide the level of transparency and rigor to build trust among the public through independent, third-party verification.
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PMC6627640
Leading edge genes from the top 20 gene sets enriched for each resistant line and related to PRC1, PRC2, and H3K27 methylation targets were extracted (Supplementary Tables S2 and S5).
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PMC8806312
Heat map. (
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PMC11190238
These upregulated PRC2-CGI genes (not the hypermethylated GCIs) are enriched in the EMT pathway in many cancer types including basal breast cancer (Basal BRCA) and lung cancers.
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PMC11634027
A-D) Male proximal anterior wings from ds/ds (A), ds/ds (B), ds/ds (C), and ds/ds (D).
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PMC11637284
Which features of the TAC60 region (E175-L198) and the p166 C-tail region (D1466-L1499) are important for their mutual interaction?
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PMC11085211
Indeed, this phytochemical, already identified as one of the primary metabolites in AUN , was identified as the most representative compound in FR2-A. Strengthened by this result, together with the knowledge that β-arbutin was already associated with proapoptotic activity in melanoma cells , we tested pure β-arbutin, unfortunately with negative results.
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PMC6222726
Bursehernin (18) was studied by Ito et al. for its inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells .
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PMC8735881
Schematic diagram of lentiviral transfer vector expressing a GPI-scFv or bifunctional inhibitor.
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PMC11306331
A Representative time course images showing dissolution 3xFUS condensates and MBP after the addition of blue light (time 0) to dimerize 3xFUS with MBP in HEK293T cell nuclei.
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PMC11621493
Lipidomic data were processed with MassHunter Workstation Quantitative Analysis for QQQ (Version 10.0, Agilent Technologies).
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PMC9429973
For patients with low PC compared to higher PC, 9/21 (43%) compared to 3/46 (7%) patients had parsaclisib dose interruption due to thrombocytopenia.
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PMC11790599
Then sections were blocked in 3% BSA in PBS for 30 min and probed with primary antibody (1:100) for 1 h. Endogenous peroxidase activity was quenched, and detection was performed using the HRP-conjugated secondary antibody followed by colorimetric detection using diaminobenzidine (Thermo).
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PMC11515150
p < 0.05 was considered statistically significant and p values were two-sided.
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PMC11285179
For example, bevacizumab, through the modulation of angiogenesis and improvement of the tumor microenvironment, lowers tumor vascular density and edema, thereby enhancing the efficiency of oxygen supply and making other treatment modalities more effective.
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PMC9352806
As we focused on the effects of BMS on lipid homeostasis, this finding prompted us to uncover whether BMS could induce lipophagy, thereby attenuating the fat accumulation and extending the lifespan as well, through increasing the level of PE.
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PMC4485786
To enhance the required antitumoral response, NHS-IL12 was combined with IL-2 or IL-7.
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PMC4360730
To annotate to the most relevant ontology term, biocurators use software tools Protégé (http://protege.stanford.edu/), Bioportal (http://bioportal.bioontology.org) (19), Ontology Look Up Service (http://www.ebi.ac.uk/ontology-lookup/) and OLSVis (http://ols.wordvis.com/) (20, 21).
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PMC11438317
After PV treatment for 5 min, cells were lysed and LP-DACS was immunoprecipitated with specific antibodies against myc, HA or FLAG epitopes bound to sepharose beads.
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PMC11201245
After hybridization, coverslips were removed, and the slide was washed in 2×SSC, 0.1% Igepal for 2 min.
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PMC11634027
dsand ds are described in the section ‘Subdivision of the D region identifies multiple, partially separable activities’.
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PMC9954564
Model selection is based on the strength of association between a set of genotypes and the binary outcome of interest, using all the data, with the statistical significance of the models being assessed through a permutation testing strategy by randomizing the case/control status in the original dataset.
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PMC11317131
We introduced several hyperactive mutations into both PASTE and twin PE PASTE but did not observe a further increase in efficiency (Supplementary Figure S7).
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PMC11792888
The culture medium was decanted, and 150 µL DMSO (100 %) was added to each well.
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PMC10547921
Slow-growing tumor cells, typically do not rely on tubulin-mediated cellular processes as much as rapidly dividing cells.
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PMC8345486
Extra-pure nitric acid (ROTH-X898.1) was purchased from Carl Roth GmbH Co. (Karlsruhe, Germany).
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PMC11377827
Cells were analysed using BD Fortessa (GFP).
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PMC3681794
Western blots are representative 3 independent experiments with GAPDH used as a loading control.
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PMC11783017
The fluorescence intensity of CRT staining of the Mn/NH@PGP and Cis/Mn@PGP groups was significantly higher than that of the Mn@PGP and PGP groups, while the Cis/Mn/NH@PGP group showed the highest degree of fluorescence intensity (Fig. S30A).
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PMC11697065
Wsb2 is involved in ubiquitin conjugation pathways whereas Col6a1, an extracellular matrix protein, is involved in cell adhesion.
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PMC5833712
b Representative Western blot analyses of ERα and ERβ expression in ERα-transfected A2780cis cells after 24-h treatment with 10 nM of KB9520 alone or in combination with 5 nM MG132.
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PMC11143482
For instance, which oncogenes are overexpressed during the cancer progression, early detection of metastasis, as well as the detection of circulating OS cells which could lead to breakthroughs in improving the survival of patients with metastatic disease.
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PMC5535901
These data helped us choose concentrations that do not affect cell viability for our subsequent experiments.
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PMC10761218
All statistical analyses were carried out using the SPSS® statistical software package for Windows®, version 15.0 of SPSS Inc. (Chicago, IL, USA).
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PMC10587429
Draw a gate to include cells that are human CD45 positive and mouse CD45 negative.
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PMC9429973
Lenalidomide is an immunomodulatory agent, which has been shown to be effective in treatment of r/r-lymphoma with an acceptable safety.
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PMC11388384
Deeper insight into the mechanisms of morphogen movement promises to unravel long-hidden biological mechanisms and could potentially inform a range of applications, including tissue engineering and drug delivery.
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PMC11474209
As a neurotoxin, it blocks open, reversible, voltage-gated sodium channels, preventing sodium ions from passing through the membrane and resulting in the nervous system's shutdown.
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PMC11621493
The enzyme showed low but detectable TAG hydrolase activity of 0.3 μmol/(mg∙h), which increased ∼ 4-fold upon CaCl2 addition (supplemental Fig. S2D and E).
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PMC9429973
Haematology, University Hospital Southampton, Southampton, United Kingdom Background: We have previously described AUTO1, a CD19 CAR with a fast off-rate CD19 binding domain, designed to reduce CAR T-cell immune toxicity and improve engraftment.
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PMC10723784
The application of CBD or CBG (1 nM–100 μM) induced dose‐ and time‐dependent cytotoxicity which were significant (p < .05, .01, .001) at concentrations higher than 1 μM when tested on all cell lines compared to the vehicle‐treated cells (Figure 1).
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PMC10490530
The ChIP experiment was performed as described earlier with few modifications .
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PMC11389534
For example, LZAP has been demonstrated to bind directly to RelA, thereby inhibiting NF‐κB transcriptional activity.
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PMC11774747
The study proposed several explanations for the rapid disappearance of circulating cells, including elimination by alloreactive T cells, short-life cells or residency at the tumor sites.
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PMC11706491
mTagBFP2 was extracted from pAV0816 and used to replace the original mCherry from SynCut3-mCherry plasmid and generate SynCut3-mTagBFP2 plasmid pAY1193.
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PMC11621565
Thus, deciphering the intimate mechanism of PD pathogenesis is the key to overcoming PD morbidity.
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PMC10669966
As frozen tissue samples for RNA extraction were not available, we used RNA isolated from FFPE samples, in which RNA is known to be degraded.
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PMC11792740
Metabolic competition between tumor cells and T cells leads to an insufficient nutrient supply, resulting in T-cell depletion (Fig. 2).
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PMC10395663
In the original publication , there was a mistake in Figure 1G.
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PMC11679033
The growth medium with tested compounds was removed by pipetting, discarded and replaced with a fresh amount of complete growth medium RPMI-1640 that contained Cytochalasin B (cytoB; Sigma-Aldrich, Steinheim, Germany) at a final concentration of 6 µg/mL. This procedure was timed to the 44 hour of lymphocyte cultivation, as that time is a critical point for the addition of cytoB to inhibit cytokinesis and obtain binucleated cells.
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PMC9429973
A. Röth, A. Karaouni, J. Msihid, I. Hemim, F. Joly, F. Shafer, T. Sourdille, Q. Hill Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany; BMAPS SARL, Geneva, Switzerland; Sanofi, Chilly-Mazarin, France; Sanofi, Bridgewater; Sanofi, New York, United States of America; Department of Clinical Hematology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom Background: Cold agglutinin disease (CAD) is a rare hemolytic anemia.
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PMC8708099
Literature data suggest that pro-inflammatory CKs activate noradrenergic transmission and the hypothalamic–pituitary–adrenal (HPA) axis, and cause glucocorticoid receptor resistance .
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PMC9429973
Chi square, Fisher’s exact test and t-test were used to compare patient’s characteristics, considering p<0.05 as statistically significant.
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PMC11670954
Such efforts will foster a deeper understanding of the complex mechanisms by which BA influences epithelial barrier function and cell resilience.
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PMC11721295
Since we showed KRAS-dependent expression of Tgfa in L-iKRAS cells, we assessed downstream signaling activation through phosphorylation of EGFR, an important growth factor receptor in lung cancer, in lung sections from L-iKRAS mice.
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PMC11470999
The effect of PF on CIP2A protein levels in A375 cells with stable knockdown of BRCA1, CUL3, RNF4, UBR5, CHIP, and VHL was analyzed after treatment for 24 h. (C) The ability of PF to downregulate CIP2A protein levels was inhibited in A375 and B16 cells with stable knockdown of VHL. (
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PMC9429973
The corresponding Kaplan-Meier curve is provided in Figure 1.
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PMC11699465
The total protein (∼20 μg) from each sample was separated by SDS-PAGE in SDS running buffer (TAKARA #T9101) at 150 V for 1h at room temperature and transferred to PVDF membranes at 300mA for 3h at 4°C.
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PMC9429973
Secondary endpoints include overall response rate (ORR) by local investigator assessment and cellular kinetics.
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PMC11806818
However, natural enzymes have several limitations, including high cost, poor stability, difficulties in long-term storage and mass production, and challenges in withstanding harsh environments.
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PMC11686380
Knockdown of endogenous GAP43 in dissociated cortical neurons.
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PMC9429973
Responders after ACTIVE + G could proceed to either allogeneic stem cell transplantation (alloSCT) or maintenance therapy with Venetoclax, Low Dose Cytarabine and Gilteritinib.
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PMC8345486
shift values in parts per million are relative to the SiMe4 internal reference.
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PMC11711127
the restriction—of Ag is one deciding parameter.
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PMC11672617
It is important to note that not all of the energy present in the electrochemical gradient is utilized for ATP synthesis.
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PMC11461874
Quantified intensities of GFP and DBP are plotted on the right as dots for individual experiments and as lines for means with SEM (n = 3) by setting the peak value to 1.
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PMC11291697
The analysis of TADs (Topologically Associating Domains) was performed with 3D Genome Browser (http://3dgenome.fsm.northwestern.edu).Fig.
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PMC11659921
To investigate the roles of angiogenesis‐ and stemness‐related genes in OV, we conducted subgroup typing of these key genes.
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PMC11583010
Recovery groups were also included.
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PMC10976516
In lung cancer and melanoma models, BOECs have previously shown their value as gene therapy vectors for systemic delivery to tumors.
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PMC11656380
Confocal fluorescence microscopy revealed that Tamra-Tat-Ram13 was significantly taken up by Tat-Ram13-sensitive CCRF-CEM and Jurkat cells (Figure 4A).
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PMC11762280
UVB irradiation induces diverse modalities of regulatory cell death in keratinocytes.
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PMC11496728
The above data were from three independent experiments, when P < 0.05, the difference is statistically significant, compared with CHO-WT, *P < 0.05, **P < 0.01, ***P < 0.001.
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PMC5311252
All miRNA transfection and virus collection steps were carried out on a Hamilton ML STAR (Hamilton Bonaduz, Bonaduz, Switzerland).
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PMC11708541
Aminopyridines are becoming essential parts of customized therapy techniques, which use drugs based on a patient's genetic composition and the specifics of their condition, as personalized medicine continues to gain traction.
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PMC11786704
The PC capsules notably enhanced the bioavailability of PC and effectively reshaped the microenvironment of diabetic wounds by inhibiting the MAPK-p38 signaling pathway, thereby achieving the desired therapeutic outcomes with a single administration.
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PMC11394227
Cells were cultured with 10 μg/mL puromycin or 2.5 μg/mL tunicamycin for 48 h. The cells were harvested and supplemented with 5 μL Annexin V-PE and 5 μL 7-AAD staining solution.
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PMC11488203
Dysregulated miRs have been shown to affect the hallmarks of cancer, including sustaining proliferative signaling, evading growth suppressors, resisting cell death, and activating invasion and metastasis .
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PMC11705067
Purpose: Targeting cuproptosis is considered as a promising therapeutic strategy for the prevention of tumors.
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PMC11551844
The intensity of the absorbance was higher for AuNPs-JDH in comparison with AuNPs-JC-2 and AuNPs-JDE.
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PMC9429973
Patients were divided into two study cohorts: the early (2012-2015) and the late cohort (2016-2020).
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PMC11429241
Said cell lines exhibit a different genetic background, morphology , and ability to form 3D cell cultures in a scaffold-free environment.
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PMC8751435
Fortunately, slight CME‐induced pyroptosis is validated in loss of function of caspase‐3 even though its clinic application needs further refinement of CME which can achieve greater efficacy, and our finding highlights rationale of clinic application of CME as a dietary therapy.
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