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PMC9429973
As predicted by the function of the gene, biochemical analyses in KO cells revealed the increase of cRel and p50 protein levels and the increase of p65 phosphorylation, all NF-κB transcription factors indicating unabated cellular activation.
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PMC9429973
The availability of more robust evidence can support decision-making process, from clinical assessment by providers, to implementation of public healthcare policies.
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PMC10891340
In conclusion, CCCP can be an effective antiviral candidate against DPV.As a highly dynamic organelle, mitochondria maintain intracellular homeostasis through their own functional fusion and fission (Ferree and Shirihai, 2012).
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PMC6799808
Low energy levels, oxidative stress or hypoxia activates AMPK, which can phosphorylate TSC2 (tuberous sclerosis complex 2) at multiple sites (including S1387), leading to activation of the TSC1/2 complex.
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PMC11126803
pRL-TK was used as an internal control.
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PMC9429973
The age range was from 1.5 to 18 years old and 25 were males.
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PMC11365427
Differential metabolite markers were identified based on strict criteria: VIP > 1 and P < 0.05.
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PMC11684269
Hence, to fill the gaps in this field and better translate basic science into clinical practice, more high-quality research is needed.
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PMC11765879
The mixture was shaken, covered with parafilm, and kept overnight.
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PMC11243198
For further confirmation, the six GANT61 analog compounds were repurchased and retested for inhibition in the C3H10T1/2 assay using SAG and as an additional control, purmorphamine (PUR) , another Smo agonist to activate the Hh pathway (PUR, EC50 = 500 nM; Supplemental Figure S1A).
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PMC11763126
Following washing steps, the membrane was exposed to HRP-conjugated secondary antibodies for 1 h at room temperature.
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PMC9847912
The toxicity of GSK232 in CEMss, 293T/17, and MAGIC-5A cells was measured using reagents from the CellTiter-Glo Luminescent Cell Viability Assay kit (Promega Corp., Madison, WI).
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PMC10772747
The extraction method used was ultrasound-assisted extraction (UAE).
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PMC11394386
Interestingly, in the SiHa cell line, BKM120 treatment led to an increase in HOTAIR expression (see Supplementary Figure S2C), indicating a possible compensatory mechanism that differs between the two cell lines.
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PMC11739504
qRT-PCR data showing a gradual increase in the level of Kat2b transcript during primary cilia formation. (
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PMC6600253
Examples of these natural bioactive components include stilbenes, which are a subgroup of polyphenols that occur in many plant species .
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PMC9429973
Furthermore, HSP110 inhibitors disrupted the binding of HSP110 with SYK in vitro, suggesting that the foldamers may act through this mechanism in vivo.
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PMC9118379
Similarly, in proteogenomics analyses, either results from a single search engine (SSe) or combined search results from multiple search engines (CMSe) are coupled with global FDR (gFDR) or class-specific FDR (cFDR) estimation for variant peptide identification.
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PMC10125312
Other studies showed how high temperatures achieved with higher laser powers favor the induction of necrosis, although apoptosis can be triggered with the combination of different types of nanoparticles and laser irradiation.
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PMC11521786
On day 49, both immunized and nonimmunized rabbits were bled, and sera were extracted from blood and subsequently dialyzed in a 0.02-M sodium acetate buffer containing 0.2 M of sodium chloride.
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PMC11754094
The cell lines were cultured for 2 weeks and each genotype was confirmed by an Illumina Miniseq instrument.
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PMC3274243
Cells were also seeded into sterile 96-well plates (VWR, UK) at a density of 2 × 10 cells well for the 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) based assay .
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PMC9429973
Baseline creatinine (HH 0.79, NHH 0.78; p=0.92) and the prevalence of cardiovascular risk factors (HH 63.6%, NHH 66.7%; p=0.31) were comparable.
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PMC9429973
Their crucial role in solid tumor and hematological malignances, including MM, is well documented.
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PMC11723947
Data are mean ± SEM of three independent experiments.
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PMC10551595
The involved amino acids in hydrogen bonds and hydrophobic interactions are represented as green and orange sticks, respectively.
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PMC7185206
Images were reviewed by a pathologist and scored positive for moderate to intense staining.
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PMC11401350
T cells were stimulated by IL-7/IL-15 or through the TCR and transduced as outlined in Fig. 2C with the indicated vectors at equivalent viral particle levels (10 ng p24).
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PMC11467800
These cells exist in a partially reprogrammed state, having lost their original identity and adopting a metamorphic condition to ensure self‐preservation.
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PMC10344560
There was no abdominal pain anymore after the surgery.
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PMC11300085
It is interesting that both primary and recurrent advanced staged OC preferentially metastasize to adipose tissue, which indicates the importance of microenvironment of adipose tissue to the metastasis cascade of OC .
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PMC11767725
These approaches, combined with systemic metabolic interventions, provide a comprehensive strategy for addressing both the localized and systemic drivers of HS, highlighting the central role of the skin microbiome in mediating metabolic interactions in this debilitating condition .
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PMC9429973
Aims: To evaluate the safety and tolerability of the novel BCMA-CD3 BsAb WVT078 in patients with r/r MM.
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PMC9429973
AFM28 is a novel bispecific Innate Cell Engager (ICE) designed for bivalent high-affinity binding of CD16A on natural killer (NK) cells, redirecting effector cell cytotoxicity to CD123 tumor cells.
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PMC9429973
G. Sotomayor Duque, W. Nava Gutiérrez, S. Baltazar Arellano, M. L. Guajardo Leal, D. G. Cruz Contreras, J. L. Cedillo de la Cerda, H. P. Sorkee Davila, J. A. Carrizales Villarreal, M. P. Pequeño Luevano, I. Borjon Cabada, C. Quirino Marquez, A. Mecott Estudillo, G. Avila Contreras, D. C. Aldama Gutiérrez, D. Garza Escobar, Y. Garcia Cerda, V. Valerio Bugarin, K. Machuca Adame, L. O. Gudiño Cobos, R. Saldaña Vazquez, R. E. De León Cantu, R. Hernadez Valdez Hematology, IMSS, Monterrey, Mexico Background: Acute lymphoblastic leukemia (ALL) is a hematopoietic neoplasm with arrest in lymphoid lineage differentiation.
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PMC6364197
Total protein (20 µg) was separated by 10% sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and transferred to PVDF membrane.
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PMC9878562
VAL-wt mixed, (ii) VAL-ko alone, (iii) VAL-ko mixed. (
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PMC11629143
After simultaneous revival, week 0 and week 10 cells were transfected with sgRNAs and dCas9, dCas9‐TET1, dCas9‐p300 or both dCas9‐p300 and dCas9‐TET1, as above (n = 3).
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PMC11576293
There are presently two approaches for developing multi-targeted medications.
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PMC11711063
The assay showed that a short‐term, 1‐h treatment was associated with a decrease in glucose uptake in vitro, confirming its potential to modulate metabolic activity (Figure 5I).
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PMC8557138
Organoid biobanking involves the collection of tissue resections after surgery and developing them into organoids that can be used immediately as live culture or frozen in liquid nitrogen (van de Wetering et al. 2015).The major challenge in developing a tissue engineering-based organoid system is that after reaching a particular size, cells stop proliferating and acquire a core of necrotic cells.
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PMC11297139
The mutant SHP2 acts as a scaffold protein that forms condensates to recruit and activate WT SHP2, promoting mitogen-activated protein kinase (MAPK) hyperactivation and the pathogenesis of SHP2-associated human diseases.
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PMC11126803
Importantly, treating with ICI 182,780 can partly block/reverse the oe-LncRNA-SERB-promoted ccRCC metastasis (Fig. 6A).
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PMC11529598
Primary antibodies were seen via binding IRDye 800CW-conjugated secondary antibody.
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PMC11098378
Moreover, these assays cannot provide insight into the strategies used by pathogens to combat host antiviral factors identified in these screens.
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PMC11733919
However, prolonged treatment (48 h stimulation) decreased the viability of red blood cells (Figure S6).
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PMC11718274
It is frequently observed in sun-exposed areas of the skin, making individuals with a history of excessive sun exposure or sunburn particularly susceptible.
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PMC11533140
Several clinical PI3K candidates were severely intolerable to patients due to fatal hepatotoxicity and, thus, failed in clinical trials.
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PMC10079526
SUMO inhibition prolonged the entrapment of DNMT1 to DNA, resulting in DNA damage.
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PMC10996034
no. A0208; Beyotime Institute of Biotechnology) at room temperature for 2 h. Bands were visualized using a chemiluminescence kit (Beyotime Institute of Biotechnology).
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PMC8540611
Uptake of complexes with AuNP15 reached 50–60% for HL-60 and CEM-SS cells after 3 h and dropped 1.5–2.5 times after 24 h incubation.
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PMC10667689
More interestingly, the metabolic profile was shown to be restricted in a time-dependent manner, as the increase in GLUT-1, HK-2, and PFKFB-3 followed an uprising trend for 48 h in HL-60 and 24 h in THP-1 (the different pattern is probably related to the heterogeneous nature of AML).
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PMC11218145
We are aware that TB was approved in humans for topical uses.
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PMC9429973
In patients in whom only medullary aspiration was performed, 36% had thrombopenias < 30,000 x10⁹/L (considering biopsy as unsafe), 61% it was not requested and 2.5% it was not technically possible.
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PMC7348793
mtDNA in COS-7 cells is present at >20 copies per cell (our unpublished observations).
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PMC9910796
For the analysis of the DNA content, triplicate samples containing 2 μg of purified vEP84Ri and vEP84Ri particles were mixed with 100 ng of purified genomic DNA from ectromelia virus (ECTV), which was used as spike-in control for normalization, and subjected to DNA extraction and purification with the GeneJET Whole Blood Genomic DNA Purification Mini Kit (Thermo).
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PMC10482220
Intracellular localization of G3BP-GFP fusion (green) in transfected HeLa cells treated with 0.5 mM arsenite for 1 h, which were fixed and stained with anti-TIA1/R antibody (red).
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PMC11461874
Data are presented as mean ± SEM (n = 3) by setting the mean of control cells to 1.
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PMC10158546
Unexpectedly, we observed weak expression of NeuN (mature neuron marker) by the ReN progenitor cells at day 0, and this expression was quickly lost upon differentiation.
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PMC11470381
Measuring Piezo1 and actin polarity in moving cells Import the exported imaging files into Fiji (https://fiji.sc/).
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PMC11680049
Generally, these compounds are predominantly located in the protective and conductive tissues, with their presence also noted in parenchymal cells.
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PMC11653168
Further research is needed to fully understand the therapeutic potential and limitations of Stattic in treating T-ALL.
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PMC9429973
OGM allows not only the detection of CNV but also the identification of two rearrangement patterns associated with chromothripsis (clustered or involving non-chromothriptic chromosomes) whose clinical impact should be further explored.
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PMC11225860
Polyploidy is a specific form of aneuploidy caused by whole genome doubling (WGD), which involves successive rounds of replication without mitosis or cytokinesis, resulting in polyploid nuclei or the formation of several nuclei within the same cell .
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PMC11754094
The points represent individual values.
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PMC11740508
All experiments use at least triplicate samples, and performed at least twice.
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PMC11705901
SNP rs4686302 has been associated with empathy and social cognitive deficits in children with ADHD .
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PMC11732523
Comprehensive investigations revealed GS, accompanied by concurrent infections with cytomegalovirus (CMV), COVID-19, Aspergillus spp, and Pseudomonas aeruginosa.
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PMC6364197
However, the high cost, easy relapse, severe GVHD side effects and technical limitations make hematopoietic stem cell transplantation hard to carry out for most leukemia patients in China (27).
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PMC11578343
In contrast, several groups , , , have recently developed platforms that can perform multi‐parameter cytometry, measuring for example, polarizability, deformability, cytoplasm conductivity, etc.
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PMC11391695
Conversely, SMMC-7721 and BEL-7404 cells treated with si-ACYP2-1 or si-ACYP2-2 exhibited a substantial enhancement in these parameters (p < 0.05) (Fig. 2C, Fig. S2B and Fig. S2C) Moreover, flow cytometry experiments demonstrated a significant increase in the number of SK-Hep-1 cells undergoing apoptosis when treated with pcDNA-ACYP2 (p < 0.01).
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PMC11770130
Many of these studies attributed the decreases in food intake to the local and direct interaction between NTS and cells in the CNS, as intracerebroventricular (ICV) injection of NTS was sufficient to reduce food intake.
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PMC9429973
Summary/Conclusion: In conclusion, the ROS low strategy permits to identify a quiescent AML subpopulation with peculiar mitochondrial features and transcriptome allowing to pinpoint novel molecular pathways that might be targeted to enhance LSCs clearance.
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PMC11026382
e Correlation between intracellular TYMS concentrations determined by model fit and lysate assay.
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PMC11770130
The homogenate was centrifuged at 4 °C, 1000× g for 10 min and two-phase layers could be observed in the glass centrifuge tube.
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PMC11572213
The primers listed in Table 1 were used to analyze TET2 and GLUL mRNA expression.
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PMC11694346
C NMR (CDCl3, 125 MHz, r.t.):
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PMC5839394
Total silver was determined in 1 mg sample of pulverized AgNPs-EPS, AgNPs-EPS and in subcellular fractions of breast cancer cell line SKBR3.
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PMC11740207
Taking AML as an example, using the HL60 cell line, it can be inferred that VSLSLCs represent a form of LT-LSLCs or their smaller-sized precursor.
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PMC11791478
Six male and six female cynomolgus monkeys were evaluated in each treatment group.
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PMC10988555
The metal complexes can damage the DNA, leading to the trigger of cell cycle checkpoints and consequently to the arrest of the cell cycle.
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PMC4443654
Here we collate large collections of matched locus-level chromatin features and Hi-C interaction data, representing higher-order organization, across three human cell types.
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PMC11453018
E LMNB1 and P15 expression (RNA-Seq) in MSC overexpressing EWS::FLI1 and GFP control cells.
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PMC11365427
Nanoflow LC–MS/MS analysis was used to identify differences in protein abundance between gel bands with and without the addition of phenylalanine.
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PMC9429973
The search for factors to predict the course of the disease remains relevant.
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PMC11530949
Collectively, these findings suggest that bimetallic Ag-doped CuO NPs synthesized using the Ephedra intermedia extract present a novel and promising therapeutic modality for liver cancer treatment.
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PMC11377827
HIF complex component levels and CA9 levels were measured by immunoblot (C).
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PMC10958426
Heatmap of SNV alternative ratios' z-score by row in each tumor subclone. (
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PMC10297204
Direct ethanol injection with high concentrations in hepatocellular and thyroid carcinoma led to a reduction of tumor relapse .
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PMC9429973
Forodesine treatment significantly prolonged survival of the mice compared with control mice, with a median survival of 17.5 days vs 14 days, respectively (p = 0.029).
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PMC11476222
Briefly, cells were lysed in a 50 mM ABC buffer via bead beating with zirconium beads.
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PMC11706491
Temperature shifts create stress, impacting cell fitness and potentially introducing artifacts due to non-optimal growth conditions .
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PMC11216402
Their role in gastrointestinal cancer (Luo et al. 2019) and cancer-associated fibroblasts (Bordignon et al. 2019) has been well established.
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PMC11693599
These results suggest that CD109 is overexpressed on the surface of ovarian CSCs in vitro.
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PMC9429973
We collected demographic data, pathologic bone marrow, driver mutations, clinical and hematologic characteristics of the study patients and correlated with disease progression.
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PMC9429973
More intensive regimens e.g. R-Hyper-CVAD have documented TRM rates of up to 8%.
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PMC11025866
Finally, genes were identified that were up- or down-regulated in those four of the conditions in which the EBV lytic cycle is not reactivated.
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PMC11769516
The authors analyzed the enzymatic protection system in an undifferentiated human neuroblastoma cell line—SH-SY5Y.
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PMC10454535
ROS exposure has been shown to downregulate catalase expression in human hepatoma cells , and another study linked low catalase expression to MM cells sensitive to ROS generation by parthenolide treatment .
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PMC9429973
The correlation between sTfR and hemoglobin reflects the importance of sTfR in the pathogenesis of anemia in cancer patients.
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