Datasets:
OTAR3088
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BioData-CellLine_annotated

Dataset card Data Studio Files
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PMC9429973
The expected study duration from first patient’s first visit to last patient’s last visit is approximately 4 years.
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PMC11796104
Moreover, novel_circ_0033084 was significantly down-regulated DEcircRNA, which was hosted by HLA-B (human leukocyte antigen-B).
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PMC11310713
Data are means ± SEM.
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PMC11656048
In this study, we found that shikonin (1.5 uM) significantly downregulated the expression of Nrf2 and upregulated the expression of Keap1 (Figures 4A, B).
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PMC11699465
Male BALB/c mice (6–8 weeks old) (Pengyue Laboratory, Jinan, China) were subcutaneously injected with 1 × 10 4T1 cells (labeled by luciferase expression cassette, Addgene 72485) in each hindlimb and randomly divided into different experimental groups 5 weeks after cancer cells injection.
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PMC10419319
SNU-8 OC cells were purchased from the Korean Cell Line Bank.
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PMC11802929
Note that two of the expressed SCT constructs were not included for 10X experiment due to low sample volume.
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PMC11591030
NO.
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PMC11792888
From all three combined treatments, cytotoxicity ranged from 67-95%, reflecting a synergistic effect (C < 1), as illustrated in the isobologram in Figure 7 C .
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PMC9429973
In the UK NHS Delivering Cancer Waiting Times: Good Practice Guide (2014), a top priority from patients for improving their experience was to be told they did not have cancer as soon as possible and, where they did have cancer, for a treatment plan to be made early.
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PMC7504302
Twenty of these were engrafted and passaged successfully for multiple generations.
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PMC9429973
Aims: To characterize the cytogenetic, immunogenetic and mutational landscape of IGLV3-21 CLL and to assess the predictive impact of this genotype in the context of novel therapies.
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PMC7582629
It has been demonstrated that RS and DHM can be used simultaneously to provide a morphological and biochemical analysis of cells and it can be applied to living white blood cells .
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PMC10522430
In addition, a peak at 1399.73 cm, corresponding to C-H stretching, suggested the existence of alkanes within the GACP extracts.
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PMC5925824
Panel b: Mixed leukocyte reactions.
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PMC11628904
Unless otherwise indicated, all data are represented as mean ± SEM (standard error) with p < 0.05, indicated by asterisk, used to determine statistical significance.
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PMC11750161
Curves fitted in a single experiment were normalized to background signals measured in mock-transfected cells.
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PMC11537649
The colony formation assays also indicated similarity results as the CCK8 assay (Fig. 6G and H).
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PMC10907726
This inhibitory effect was significantly attenuated by the addition of 3-MA.
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PMC10631132
Additionally, both undifferentiated iPSC populations yielded a small fraction of a CD265 subpopulation.
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PMC11540664
Sorafenib orally 400 mg 1/day.
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PMC11792766
HepG2 presented a decrease of 22% in their mean viability, whereas the decrease was more pronounced for Caco‐2 cell line which presented a total loss of viability at 0.15% v/v acetic acid concentration.
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PMC11228511
P < 0.001.
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PMC6642070
Co-administration of DCA is a potential avenue to alleviate the symptoms.
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PMC11679326
Intriguingly, A2G2F is expressed in the brain only during embryonic development .
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PMC9429973
We found that IL21 is a positive prognostic marker for OS and that higher serum IL21 levels correlate with better survival and higher rate of complete remission in patients that undergo chemotherapy.
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PMC9727330
Interestingly, in both cancer and normal cells, the mean absorbance of treated cells showed constant values in response to Asp and NNDAsp (Figure 1B and Table 2).
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PMC11423992
This design concept was inspired by literature findings that highlighted the high homology between an IgG1 CH3 domain pair and a CH1-CL heterodimer (Fig 1B) .
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PMC11488203
These vesicles include EVs/exosomes that carry various regulatory biological compounds such as proteins and miRs for cellular communications with other cells.
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PMC11757131
Knock-out of the HIBCH gene in mouse skeletal muscle cells inhibits the transport of fatty acids, whereas knock-out of the 3-HIB metabolic enzyme, 3-hydroxyisobutyryl-CoA dehydrogenase (HIBADH) to reduce the metabolic rate of 3-HIB, substantially increases cellular fatty acid intake (10).
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PMC9509578
The reoccurrence of tumors and associated relapse or deaths of cancer patients are mainly attributable to either the intrinsic or acquired phenomenon of MDR.
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PMC11768281
A distinction between acute and chronic malaria onset is necessary, as these conditions involve different mechanisms.
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PMC11483468
These results indicated that the TAT-LPTS39 polypeptide could inhibit the growth of BEL-7404 cancer cell CDX.
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PMC11033180
COS cells suspended in Matrigel were deposited in the center of the ENS culture well and cocultured for 3 days before measuring axonal complexity using Sholl analysis.(B) Schematic depicting Sholl analysis.
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PMC11739504
DsRed tagged Kat2b constructs were investigated vector transfected cell and nuclear localization signal domain deleted Kat2b positioned only cytosol. (
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PMC9684669
Indeed, terfenadine decreased the expression of the ABCB1 protein in a dose-dependent manner ( Figure 3F and Figure S4A ).
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PMC11775197
Moreover, their antagonists can counteract PPE’s positive tumor angiogenesis inhibitory effects .
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PMC11803918
Similar to that in nude mice, both γδ-T exosomes and Ce6-loaded liposome treatments could control melanoma tissue growth, and the hybrid exosomes exhibited a synergistic effect on suppressing tumor growth during the treatment in humanized mice (Figure 8B–D), indicating a therapeutic advantage of the hybrid exosomes ove...
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PMC10698968
Furthermore, nucleolar irregularities in size and shape have been correlated to cancer and are recognized as valuable biomarkers of cancerogenesis and aggressiveness in several human tumours [31–33].
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PMC7039683
This implies that although both of these transcription factor families are essential for periderm development, Grhl proteins function much more broadly than their Irf6 counterparts.
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PMC11705484
Fluorescent imaging of tumours in nude mice xenografted with 5637 cells stably transfected with a control vector (sh‐NC) or TRMT61A shRNA construct (sh‐TRMT61A). (
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PMC11420784
Inhibitor-treated mouse bladders showed reduced exocytosis of ΔpldA to levels similar to those of WT or ΔpldA+ (Figure 1B).
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PMC11792740
Successful treatment of acute lymphoblastic leukemia and diffuse large B-cell lymphoma . -
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PMC11566417
The secretome of primary bovine mammosphere-derived epithelial cells (MDECs) has been shown to exert antimicrobial, regenerative, and immunomodulatory properties in vitro, which warrants its study as a potential biologic treatment with the potential to be translated to human medicine.
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PMC11638288
Injecting soluble NKp46 variants into female NOD mice almost completely prevented the development of diabetes, whether during the early stage of pancreatic inflammation or the prediabetic phase .
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PMC9429973
Care for patients (pts) with SCD may be influenced by HCP specialty and care setting (Smeltzer et al. BMJ Open 2021).
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PMC11194678
Statistical data for the sizes of endogenous STAU1 puncta in A. >200 puncta were counted for each batch. (
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PMC11638288
Furthermore, some studies have found that in other autoimmune diseases, such as rheumatoid arthritis, colitis induced by innate immune hyperactivation, and CD4Th17-mediated neuroinflammation, NKp46 promotes the progression of these diseases .
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PMC9429973
While RUQ pain was more likely to be the second or third feature in children, it appeared first in around 85% of adults compared to 50% of children, suggesting it presents later in children in relation to other symptoms or is more difficult to detect.
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PMC11742290
Another in vivo CRC study showed that LGR5 suppressed metastasis as only 29% of control group mice had lung or liver metastasis compared to 77% of LGR5-KD mice which had lung or liver metastasis .
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PMC11733919
b–e) Results are presented as relative fluorescence units (RFU).
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PMC11714165
The treatment scheme was illustrated in Figure 5A.
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PMC10882807
All participants signed informed consent forms in this study.
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PMC10723784
This value was significantly reduced in the presence of varying concentrations of α‐tocopherol when tested on both carcinoma cells.
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PMC10142392
The discovery of liposomes dates back to the early 1960s, when Alec Bangham first identified these structures as models for cell membranes .
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PMC11657695
The current density–voltage relation was obtained by dividing the averaged steady-state currents by the respective cell capacitance.
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PMC10808409
Moreover, the gene level of TP53INP1 in the cells exposed to FA from TPGS mixed micelles formula was significantly increased compared to free FA.
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PMC11078693
Count the total number of cells for step j.f.
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PMC11519583
Right graph shows proportion of cells with blebbed nuclear membrane (n = 3).
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PMC10988555
The human ovarian carcinoma (A2780) cell line was cultivated using RPMI (Roswell Park Memorial Institute) medium supplemented as in DMEM medium.
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PMC11753949
To delve deeper into the contribution of synaptopodin to spine apparatus formation, we explored its occurrence throughout evolution.
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PMC8996378
A study showed that the saturated five membered ring had an important effect on the activity (Zhu et al., 2016).
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PMC11765678
Key problems associated with MDR include genetic mutation , tumor heterogeneity , enhanced repair of DNA damage , and increased efflux of drugs via ABC transporters expressed in tumor cells .
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PMC11745823
According to WHO classification, gliomas can be divided into grades I–IV, with grades I and II being low‐grade gliomas (LGG) and grades III and IV being high‐grade gliomas (HGG).
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PMC9429973
Aza will be administered at 75 mg/m IV/SC daily on days 1-7 (or days 1-5, 8-9) followed by tamibarotene/placebo at 6 mg BID orally days 8-28 of each 28-day cycle.
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PMC10154097
Zhu et al. have shown that it could inhibit lung cancer proliferation via regulating epidermal growth factor receptors .
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PMC11546117
The primary mammary epithelial cells are the preferred cells in light of the objective of this study, as they result in the most biorelevant model, but also have the ability to form a tight barrier suitable for permeability experiments.
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PMC11772585
In macrophages, ATF4 has been identified as a key glycolytic activator that contributes to the inflammatory response in sepsis by binding to the promoter region of Hk2 .
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PMC11453018
In a subset of ES cancer cell lines with non-functional P53, EWS::FLI1 binds to a single GGAA motif in the regulatory elements of P15, independent of P300, and represses its transcription.
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PMC8839885
After additional 24 h incubation, the attached cells were collected using trypsin in RPMI medium.
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PMC11794588
This substance is a member of the sesquiterpenoids class of organic substances.
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PMC11469524
The models cover both membrane proximal, early signaling events and to some extend downstream signaling events.
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PMC9429973
Methods: Cryopreserved BM-MNC from 3 non-CHIP controls, 3 CHIP individuals, 14 LR-MDS and 5 HR-MDS patients were obtained from the MDS registry and the BoHemE Study (NCT02867085) at the University Hospitals in Dresden and Leipzig.
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PMC11755467
We selected cell lines CEM-SS and MT-4 both derived from acute childhood or adult T lymphoblastic leukemia.
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PMC11767817
Both compounds alter cell cycle progression by blocking the cell cycle in the G2/M phase and decreasing the percentage of cells in the G0/G1 phase.
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PMC9429973
Generally, the efficacy and safety profiles of ruxolitinib in the treatment of Chinese MF patients were basicly consistent with other studies.
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PMC10957991
For that, growth factor reduced, GFR, matrigel was thawed overnight (o/n) at + 4 °C (#356230, Lot.
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PMC6114978
Western blot images were exported as tiff files and converted to grey scale jpeg images with Photoshop.
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PMC11695623
When DCUN1D5 was divided into high expression group and low expression group in TCGA, we found that there were significant differences in the infiltration levels of B cells, CD8+ T cells, DC, Mastcells, pDC, T cells, Th17 cells and Th2 cells (Fig. 7D).
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PMC8009078
Molecules found common in both Glide and ADV docking studies and screen out through the threshold value of Camostat and Ambroxol were further used to calculate the binding free energy through Prime-MMGBSA.
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PMC11711871
Following high salt exposure (6% for 5 weeks), these rats developed salt-sensitive hypertension accompanied by deregulated adrenal sEH, leading to a plasmatic increase in inactive omega-3 and omega-6 metabolites and altered aortic vascular reactivity.
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PMC10135767
Likewise, the peak time of calcium signaling decreased as the wall shear stress increased (Figure 4C).
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PMC11718274
Cancerous A-431 cells were mixed with a 20 mM solution of DCFH-DA dye and incubated in the dark at room temperature for 30 min.
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PMC9792775
Animal treatment and surgical procedures were performed in accordance with “Principal of Laboratory Animal Care” from National Institute of Health and were approved by the Institutional Animal Ethics Committee [SYXK (Beijing) 2014-0003].
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PMC11409031
L–O) Alterations in the transcription of P21, BAX, CDH1 and CDH2 following inhibition of PFN1 in the HEY cell line.
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PMC11726848
After the agarose with cells solidified (5 min at 4 °C), a top layer of 0.5% LMA (15 μL) was applied and left for 5 min at 4 °C to solidify.
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PMC4005030
Protocatechuic acid present in the aqueous extract of petals of Hibiscus sabdariffa exhibited antihypertensive and cardioprotective effects in established stages of 2-Kidney, 1-Clip renovascular hypertension model in rats.
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PMC11352311
The results provide evidence supporting the clinical application of esculin and introduce a promising new candidate for RCC treatment.
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PMC11683240
Carbamidomethylated cysteine was considered as a fixed modification along with oxidation (M) and deamidation (NQ) as variable modifications.
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PMC3681794
Hypoxia is common in adult solid tumours and is associated with treatment resistance and poorer outcome.
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PMC9429973
Levels ≥30% are considered as positive, while levels ≥50% are considered highly protective against severe disease.
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PMC11714165
PBS was used as a negative control.
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PMC11694625
4,6-Bis(2-((E)-quinolin-8-ylmethylene)hydrazinyl)pyrimidine (3b).
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PMC11699178
If the ANOVA results indicated significant differences, Tukey's Honestly Significant Difference (HSD) post-hoc test was performed for further comparisons between groups.
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PMC11476666
To examine the effect of the molecules on the stem cell fraction within the A549 cells, Hoechst 33342 cells (SP fraction) and Hoechst 33342 cells (MP fraction) were sorted from A549 cells by flow cytometry (Figure S1).
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PMC5925824
Underlined is the human PD-1 6Ǻ binding site on hu-PD-L1 (according to PDB: 4ZQK (26602187)).
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PMC11347429
HES4 (Hes Family BHLH Transcription Factor 4) is predicted to be part of the chromatin and to enable DNA-binding transcription factor activity and RNA polymerase II sequence-specific DNA binding activity.
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PMC7553912
RTECs and renal fibroblasts were isolated from the kidney of C57BL/6 J mice on day 3.
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PMC3681794
RNA was extracted and qPCR performed for CA IX and Glut-1 expression.
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PMC11033180
Under resting condition, Sema5A increased phosphorylation at Ser603 while no modification of phosphorylation was observed at Ser9 and Ser62/67.
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