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PMC8357004
Asterisks (*) indicate significant differences between the treated and untreated groups The relative expression level of p16INK4a, p14ARF, p15INK4b genes in the Caco-2 cell line treated with 5-Aza-CdR (5 μm) in combination with TSA (2.5 μm) versus untreated control groups (24 and 48 h).
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PMC10849234
Studies of neutrophil functions in humans have been hampered by the short life span of the cells ex vivo: primary neutrophils only survive for about a day following isolation from the peripheral blood, severely limiting the amount of forward and reverse genetics that can be done to identify regulatory players in human ...
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PMC9429973
In the subsequent phases of the study, 9 patients (Cohort 1) will receive 8 weekly injections.
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PMC11705484
RIP assays confirmed the interaction between YTHDF1 protein and HMOX2 mRNA; the interaction was attenuated upon TRMT61A knockdown.
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PMC11088135
Studies have shown that lncRNAs could achieve their biological functions by regulating gene transcription, acting as signaling molecules, scaffolding protein complexes, and participating in regulating a variety of biological processes .
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PMC10976516
Jiang et al. (Table 2) infected CIKs with oncolytic adenovirus ZD55-bearing TNF-related apoptosis-inducing ligand (TRAIL), manganese-containing superoxide dismutase (MnSOD), and TRAIL-isoleucine-aspartate-threonine-glutamate-MnSOD.
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PMC11594588
The epigenetic regulation of platelet mtDNA is of particular importance, as a higher platelet mtDNA methylation may be a potential biomarker of cardiovascular disease (CVD) .
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PMC8735881
The inhibitory activity of GPI-anchored scFvs or bifunctional inhibitors on Env-mediated cell–cell fusion was determined by a dual-split-protein (DSP)-based cell–cell fusion assay as described previously .
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PMC11300639
Aberrant hyperactivation of the cyclin D-CDK4/6-Rb signaling pathway promotes the progression of solid tumors by controlling the cell cycle and cell proliferation .
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PMC9927933
To determine the nature of growth suppression, we performed fluorescence-activated cell sorting (FACS) profiling and found that UBE2C knockdown caused significant G2/M arrest in both A427 and H23 cells (Figure 1, H and I), and an increased sub-G1 population, indicative of apoptosis in H1792 cells (Figure 1J).
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PMC11487720
WWOXd cells in turn induce apoptosis of WWOXf cells from a distance without physical contact .
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PMC8873393
Meanwhile, the result showed that MRC5_VA cells demonstrated largely complete repair of CPDs 24 h post irradiation (Fig. 1C).
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PMC10419319
Isoalantolactone, a sesquiterpene lactone isolated from Inula helenium L., possesses various pharmacological properties, including anticancer activity.
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PMC11473843
The cells were allowed to migrate for 12 h upon treatment with DMSO (control), XMD8-92, and Seliciclib either alone or in combination.
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PMC11754094
Transfection was carried out with psPAX2 (Addgene, 12260), pMD2.G (Addgene, 12259) and library plasmids using polyethyleneimine (Sigma-Aldrich).
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PMC11747467
For instance, a clinical trial involving advanced non-small cell lung cancer showed that a combination of ART and cisplatin had a strong inhibitory effect, with ART not causing a significant increase in toxicity (43).
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PMC8540611
was calculated relatively to the control (not treated).
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PMC11754291
Additionally, in non-irradiated melanocytes, the addition of conditioned medium from irradiated keratinocytes (CM-iK), which were cultured for 7 days and exposed to light 3 times, further enhanced Tyrosinase expression during the 12-day culture period.
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PMC11684297
The presence of giant cells was also observed in 50 µg/ml ZnO-NF treated cells indicating that the cells are targeted towards autophagy due to survival struggle .
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PMC11518702
KIT-mediated pY modulation of RHEX is also depicted.
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PMC9429973
EFS, the primary endpoint, was calculated from randomization to whichever occurred first of relapse or M2 BM after CR, failure to achieve a CR at the end of treatment, second malignancy, or death (any cause).
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PMC11352311
We then used molecular docking technology to analyze the affinity and predicted the amino acid residues where esculin binds to these proteins.
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PMC9429973
Median number of prior lines of anti-cancer therapies is 3 (range 1-8).
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PMC10729469
However, such polyclonal Tregs could also lead to global immune suppression and consequent increased prevalence of infectious or neoplastic diseases.
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PMC11139449
The primary vector utilized in this study was the pSpcas9 (BB) 2A-Puro V2.0 vector (Addgene), commonly referred to as the pSpcas9 vector (PX459).
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PMC8427838
A HEK-293 cells and HEK-293 cells expressing TMIGD1 were transfected with Life-Act7.
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PMC10958426
Box plot of interaction weight of 6 cytokine and adhesion shared pathways (FN1, VISFATIN, THBS and TGFb; PTN and CXCL), one cytokine specific pathway (MIF), four adhesion specific pathways (COLLAGEN, LAMININ, MK and CDH1) that in tumor and normal tissue.
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PMC8839885
Secondary antibodies, HRP-linked anti-rabbit (#7074, Cell Signaling Technology) and anti-mouse (NB7539 Novus, Centennial, CO, USA) were used according to the manufacturers’ instructions.
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PMC11585254
ANOVA was followed by Dunnett’s, Bonferroni’s, or Šidák’s multiple comparison test, as indicated in the figure legends.
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PMC9479186
In addition, NDUFC1 could correlate positively with cancer-related pathways, among which the p53 pathways and the PI3K/Akt/mTOR pathways.
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PMC11607764
P < 0.05 is considered as statistically significant.
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PMC11409031
Employ a tree diagram to depict the nine modules within a scale-free network. (
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PMC11607638
C. elegans behavior is regulated by food‐related sensory input in this conserved dopamine‐SK signaling pathway.
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PMC11592008
Compared with HaSKpw, the HaCaT and SVTERT cell lines demonstrated more than two-fold lower IL1B mRNA levels.
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PMC11773391
The animal protocol was approved by the Dushu Lake Hospital Affiliated to Soochow University (Soochow University, China).
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PMC10874773
In the paper, the chemical constituents and pharmacological effects of SPS are reviewed, and the potential trend and scope of future research are discussed.
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PMC11758416
Plate isolated and counted T cells into 24-well plate at a concentration of 5E5 per 1 mL per well or in desired concentration in desired plate size.h.
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PMC11755467
Additionally, we only observed a slight partial rescue of hsa-miR-132 on HIV-1 replication.
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PMC11786704
In this study, we systematically explored the regulation mechanism of PC capsules on ROS generation, apoptosis and inflammatory response in cellular.
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PMC11486946
Gray lines indicate phosphorylation and expression levels in untreated cells.
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PMC11657744
Data are presented as means ± SEM from three independent experiments.
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PMC11361748
Dashed lines depict the dermo-epidermal interface.
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PMC11767817
The 5637 cells were cultured in Roswell Park Memorial Institute 1640 (RPMI-1640), while SCaBER cells were cultured in Eagle’s Minimum Essential Medium (EMEM), supplemented with 10% (v/v) FBS, 2 mM l-glutamine, 1% (v/v), 100 U/mL penicillin, and 10 mg/mL streptomycin.
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PMC9479186
Twenty nude mice were randomly divided into four groups and inoculated with 1-ml cell suspension.
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PMC9429973
Normal karyotypes were detected in 10 patients (55,6%), 6 patients with RCC, 3 with MDS-EB and 1 with t-MDS.
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PMC9454178
B, C qRT–PCR and immunoblotting analyses showed that OSR1 expression was inhibited by CDK7 knockdown or THZ1 treatment in a dose-dependent manner.
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PMC11703896
The binding affinity of rapamycin to EGFR receptors (-8.8 Kcal/mol) was greater than the binding affinity of EGFR positive controls, including gefitinib (-6.3 Kcal/mol), osimertinib (-6.1 Kcal/mol), and erlotinib (-4.9 Kcal/mol).
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PMC11752767
Unfortunately, a phase I/II clinical trial centered on TCR targeting MAGE-A3 antigen in patients with advanced melanoma has shown a predisposition to neurotoxicity.
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PMC9429973
Pre-clinical data showed that pharmacological modulation of S1P receptor (S1PR) signalling by KRP203 sequesters T cells in lymphoid organs and prevents their egress to aGVHD target sites.
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PMC10955424
7Identification of metabolites that are enriched in malignant ascites and cirrhosis ascites fluid. (
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PMC11656657
However, to date, only few clinical trials employing CAR T-cells has been reported for sarcoma patients, targeting specifically HER2 antigen , epidermal growth factor (EGFR), the cancer/testis antigen NY-ESO-1, B7-H3 antigen, glypican 3 (GPC3) and, more recently, the disialoganglioside GD2 antigen .
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PMC11709639
These findings have the potential to significantly advance our understanding of AD pathogenesis and pave the way for effective treatments for AD.
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PMC11342785
Droplet number was respectively: DDX4-CORE, n = 179; FUS-CORE, n = 57; FUSY27S-CORE, n = 11; LAF-1-CORE, n = 0; TPPP-CORE, n = 0.
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PMC11731161
UbiBrowser 2.0 database was additionally employed to predict the potential ubiquitin ligases (Fig. 3B) and deubiquitinases (Fig. 3C) of XPO1 with high confidence.
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PMC11525028
ASNS expression in NAT10-KO cell lines by immunoblotting. (
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PMC11045125
In contrast to EBV+ Akata cells, EBV-negative Akata cells are unable to form tumors in NSG mice and are more susceptible to apoptosis-inducing stimuli .
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PMC9429973
Relapse rates were lower in more recent years; 1-year HR 0.88 (0.81-0.95, P=0.001), respectively.
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PMC9429973
Median TSS changes at EOC6 in JAKARTA2 were greater for pts with larger spleens, −36% and −49% in the <mSS and ≥mSS cohorts, respectively.
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PMC11509224
Compound 61 ((1S,3S,4R,7S,8S,11S,12S,13S,15R,20R)-7-formamido-20-isocyanoisocycloamphilectane) contains both formamide and isonitrile functionalities, which is not usual for natural products.
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PMC6268318
The hepatoprotective effects of the ethanolic extract of C. dolichopetalum root bark were evaluated on paracetamol-induced liver intoxication in rats.
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PMC8427838
These data demonstrate that loss of TMIGD1 in mice interferes with the apical localization of the ERM proteins, moesin and ezrin.
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PMC11063646
Based on the ANOVA through model F value and p-value which states that the model terms A/ B/ AB/ A/ B are significant.
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PMC11301095
Considering that the child weighed about 60 kg, we referred to the adult dose for treatment, including Amphotericin B (10 mg/dose, intravenously once daily), Rifampin (0.3 g/dose, orally twice daily), Sulfamethoxazole(400 mg)-Trimethoprim(80 mg)/tablet (3 tablets per dose, orally four times daily), and Fluconazole (0.4...
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PMC9398137
The number of apoptotic cells was determined by flow cytometry (BD FACS Canto II) using Annexin V FITC staining kit (Apronex, Czech Republic).
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PMC11476004
One of the diseases resulting from genome instability is cancer, which arises from unlimited and uncontrolled cell division.
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PMC7057940
On the other hand, samples from patient 2, also pulmonary tissue, were included in the study after having undergone histopathological analyses that suggested a case of ES with primary origin in the left femur and lung metastasis.
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PMC8316344
To minimize ROS-incurred over lipid peroxidation, antioxidant defense enzymes are employed .
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PMC11218145
Malignant Pleural Mesothelioma (MPM) is a rare malignancy with a poor prognosis.
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PMC11128598
This approach is particularly interesting when synergistic interactions are achieved and especially when it involves repurposing drugs, as it would reduce timelines and cost compared with de novo drug development.
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PMC9429973
Olipudase alfa, intravenous-recombinant-human ASM, is in late-stage development (Sanofi Genzyme) for non-central-nervous-system manifestations of ASMD.
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PMC6102174
This is the first time to systematically investigate the xanthones and their anti-HBV activity in Swertia plants.
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PMC11502327
However, the pharmacokinetics of CPT are poor and the toxicity of intravenous administration is high, so effectively breaking through the above limitations is the key to expanding clinical application.
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PMC9813422
Unlike the two herpesviruses previously introduced, HPV is a virus that completes its entire production life cycle with a circular episome in infected basal epithelial cells.
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PMC6182045
Protein PI standards included the Amyloglucosidase from Aspergillus niger (97kDa, pI = 3.6, upward pointing arrow) and/or bovine carbonic anhydrase isozyme II (29kDa, pI = 5.9, downward pointing arrow) are indicated.
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PMC11621565
Our in vitro study offers significant insights into the potential mechanisms by which microbiota-derived molecules, particularly rhamnolipid and LPS, contribute to PD) pathogenesis.
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PMC11545737
Another factor that plays a role in Neisseria-induced pyroptosis is hemagglutinin/hemolysin-related protein A (HrpA), the secreted portion of the two-partner HrpA/HrpB secretion system .
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PMC9429973
To functionally validate our findings, we performed ex vivo drug treatment and subpopulation specific BH3 profiling.
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PMC11787381
Animals were placed in a pool of water colored opaque with a non-toxic tempera paint.
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PMC9872547
Therefore, this nanostructure of curcumin has significant potential to be used as a complement drug for cervical cancer treatment.
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PMC11736898
Interestingly, migration was increased in normal keratinocytes treated with VID400 + vitamin D compared with either VID400 alone or untreated cells, without significant impacts on proliferation, suggesting the possibility that combination of VID400 with vitamin D may accelerate wound closure.
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PMC11615743
In situ, cell membrane HCR reactions were performed in PBS (C) or RPMI 1640 medium supplemented with 10% FBS (E).
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PMC11653533
Again, GS-MS analysis of F. benghalensis aerial roots exhibited lupenyl acetate, α-amyrenyl acetate, γ-sitosterol, palmitic acid, and lupeol, which have antibacterial, antioxidant, anti-inflammatory, anti-diabetic, and anti-cancerous potential (Verma et al., 2015).
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PMC11281366
Our results show that HIV-1 reduces the level of this miRNA during infection likely via the expression of a viral protein for which the identity remains to be defined.
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PMC11644761
Thus, pterostilbene is unable to counteract the reactivation of the cell cycle; in fact, in differentiated cells treated with forskolin, its effect does not reduce the proportion of replicative cells expressing Ki67, nor does it significantly alter the proportion of cells expressing AT8, which remains almost constant.
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PMC9646302
Our results demonstrated that LAPTM5 expression in patients with ccRCC was significantly higher in the tumor group than that in the adjacent nontumor group.
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PMC11713609
Indeed, the lipoxygenase ALOX12 was identified as a critical factor in ROS-induced ferroptosis during p53-mediated tumor suppression (Chu et al., 2019), and our recent study further showed that PHLDA2 is able to recognize phosphatidic acid and induce its peroxidation by recruiting ALOX12 for tumor suppression (Yang et ...
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PMC11194678
We further identified the critical residues driving the LLPS of RBD23.
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PMC9429973
Acalabrutinib was used at the dose of 100mg twice daily in all 3 studies.
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PMC11748335
Samples were washed by Buffer PE (Qiagen, 19065) three times, and DNA was eluted by 55uL of sterile water and incubated for 5 min before being spun at 17,900 g for 2 min.
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PMC11033180
Data are mean ± SEM. (
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PMC9429973
Annexin staining and western blot analyses were performed at both 24h and 48h to assess the efficacy of the treatment.
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PMC11772449
Current multi-party studies have confirmed that PFD can have a good and extensive anti-fibrosis effect, and the reason may be that it acts on a variety of cytokines and inhibits their functions.
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PMC11488203
While taxol exposure of MSC was associated with an increased SDF-1 expression in the derived exosomes, this suggested a selective tropism towards CXCR4-/CXCR7-carrying tumors.
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PMC11786767
C and E: The results of line scanning.
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PMC11473843
Gene set enrichment analysis (GSEA) (Subramanian et al, 2005) was run in ClusterProfiler v4.6.0 (Wu et al, 2021) using genesets from KEGG (Kanehisa et al, 2022).
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PMC10778532
We found that VHL-C162F cells display a higher healing ability than wild type (WT) VHL cells.
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PMC9429973
Our group recently demonstrated through single cell analysis that MPNs progression is due to increased genetic heterogeneity, loss of heterozygosity and parallel AML evolution.
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PMC11098378
The closest homolog of Ceg10, the Legionella pneumophila effector RavJ, is the only homolog that includes an analogous tryptophan (Trp-172) and aspartate (Asp-24), but the cysteine (Cys-101) is neither modified nor modeled in multiple conformations.
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PMC11583690
A mixture of CTAB (250 mg), Milli-Q water (120 mL), and 1M NaOH (1,752 μL) was prepared in a 250 mL round-bottom flask.
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PMC10577955
Finally, by targeting the Let-7 miRNA/Cyclin D1/VEGF cascade, acetoxy-lup-5(6), 20(29)-diene could be a potential therapeutic agent for lung cancer.
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