OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11762280	DSF disulfiram.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "DSF", "disulfiram", "." ] } ]
PMC8658661	At the same time, plasma proteins such as ceruloplasmin (CP) and hemopexin (HPX) were detected in trace amounts or were not found at all in HepG2 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11064533	Δffp and its complementation, i.e., Δffp + pBAD33 ffp had no significant impact on adhesion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Δffp", "and", "its", "complementation", ",", ...
PMC11484188	For comparisons between two groups, two-tailed unpaired Student's t test was employed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "comparisons", "between", "two", "groups", ",", "two-tailed", ...
PMC11781181	SJS and TEN are severe, life-threatening mucocutaneous reactions characterized by widespread keratinocyte death, blisters, and mucosal sloughing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SJS", "and", "TEN", "a...
PMC9429973	Breakthrough hemolysis events were infrequent: 5/128 patients (3.9%); no event was considered free C5-related.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Breakthrough", "hemolysis", "events", ...
PMC9429973	The adjusted mean difference in maximum percentage reduction in serum tryptase comparing avapritinib to BAT was -69.8% (95% CI: -89.4%, -50.2%; P<0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6892818	Our study provides the first systematic investigation of the effects of CD40 ligation in RCC cells as well as compared these effects to normal (HRPT) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC10040136	All experiments were repeated at least thrice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "repeated", "at", "least", "thrice", "." ] } ]
PMC10698968	The choice to use the osteosarcoma cell line 143B as reference to compare this new MFS cell line was dictated by three major points: i) each of soft tissue sarcomas (STSs) subtype has distinct features that make it unique and difficult to compare with other STSs; ii) 143B cell line has been extensively studied and char...	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	All the pts were infused with more than 2 x10 CD34+ cells /kg (median number of 2.7 (2.2 -3.4)) without any manipulation of the graft.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10033453	Cytotoxicity measured by MTS (Promega).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytotoxicity", "measured", "by", "MTS", "(", "Promega", ")", "." ] } ]
PMC11087766	For example, PhiKZ PicA-sfGFP localized into a single punctum at the nuclear periphery during PhiKZ infection (Fig. 2H) but is diffuse in uninfected cells (Fig. 2K).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655498	Zp and Rp are heavily methylated and silenced in latent infection, whereas histone acetylation of Zp and Rp enhances gene accessibility and promotes the binding of transcription factors during lytic replication (Speck et al., 1997; Miller et al., 2007; Woellmer and Hammerschmidt, 2013; Daskalogianni et al., 2015; Guo a...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11698348	Furthermore, Elf5 is recognised as an important suppressor of EMT and inhibitor of metastasis in breast cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "Elf5", "is", "reco...
PMC11277157	We identified a small set of genes that was substantially downregulated along with the KD of DJ-1 (57 genes).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "identified", ...
PMC9429973	Of 7 pts who experienced 13 thromboembolic events, timing of the events relative to splenectomy was known for 6 pts, and in all 6 pts, the thromboembolic events occurred after splenectomy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721096	The ligand fishing strategies were established utilizing the recombinant cell to screen compounds from complex natural product systems efficiently and accurately.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ligand", "...
PMC9429973	A. Mori, M. Onozawa, S. Tsukamoto, T. Ishio, E. Yokoyama, K. Izumiyama, M. Saito, H. Muraki, M. Morioka, T. Teshima, T. Kondo Blood Disorders Center, Aiiku Hospital; Department of Hematology, Hokkaido University Faculty of Medicine; Sapporo Clinical Laboratory Inc.; Division of Laboratory, Aiiku Hospital, Sapporo, Japa...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: The study included 109 patients with SCD and 19,3% of them (21 patients) required neuroimaging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "The", ...
PMC11449273	Previously, using various carcinoma cell lines we showed that plakoglobin interacted with wild-type and several endogenous p53 mutants (e.g., R280K, R273H, S241F, S215R, R175H) and restored their tumor suppressor activities in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11380329	Furthermore, such co-supplementation with vitamin D inhibits predominately the proliferative activity of cell population with the French propolis type as manifested by Ki67 expression, while it reduces considerably its expression, particularly with the German type, followed by the Egyptian one.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10823017	Following treatment, the invasive cells of the lower chamber were stained with crystal violet and the photographs were taken with 1X resolution using a microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11594641	We speculated whether the difference in the Rab27A levels translates to various functions of melanoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "speculated", "whether", "the", "difference", "in...
PMC11264242	EGR1 is a direct target of SS18-SSX (de Bruijn et al., 2006; Lubieniecka et al., 2008) and its transcription level is negatively correlated with SS18-SSX activity in synovial sarcoma cells (Su et al., 2010; Laporte et al., 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10203589	There is a positive correlation between the exonic region of IgII,IgIII and Igii-Igiii linker and the ligand-binding reaction (194).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There",...
PMC8973725	The relative expression level of ZNF677 mRNA and protein in the ccRCC 786–0 cell line was clearly decreased compared with the immortalized human proximal tubular cell line HK-2 cells evaluated by qPCR and Western blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11672881	These findings indicate that the combination induces cytotoxicity in melanoma cells driven by mitochondrial ROS generation and apoptosis induction through the mitochondrial pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These",...
PMC8345486	The increase in apoptosis was accompanied with a proportional increase in the compound accumulation (Figure S4, Supplementary Materials).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "increase", ...
PMC11621565	The data were normalized to GAPDH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "were", "normalized", "to", "GAPDH", "." ] } ]
PMC10213179	In brief, after the chip was equilibrated with 10 mM HEPES and 150 mM NaCl (pH 7.4), the surfaces of the flow cells were activated for 10 min with a 1:1 mixture of 0.1 M NHS (N-hydroxysuccinimide) and 0.4 M EDC (3-(N,N-dimethylamino) propyl-N-ethylcarbodiimide) at a flow rate of 10 μL/min and at a temperature of 37°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Mitochondria were evaluated by flow cytometry and transmission electron microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mitochondria", "were", "evaluated", "by", "flow", "cytometry", "and", "transmission", "electron", ...
PMC7504302	The human CDKN2A gene encodes two distinct tumor suppressor proteins resulting from translation of the common second exon in alternative reading frames (ARFs), namely, alpha and beta.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10237474	As in (A), but with protein 6 with a C-terminal His6 tag expressed from CHO-K1, HEK293S GnTI and Expi293F GnTI stable pools.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11128598	One such effect is the production of ROS, that we previously observed in ovarian cancer cell lines (3) and have also been reported in other tumor types (44–47).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11469524	Afterwards we probe the network for superfluous or missing links and repeat the procedure for every step-wise development of the network.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Afterwards", "we", ...
PMC11615743	T/H indicates the concentration ratio of toehold to HCR hairpins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "T/H", "indicates", "the", "concentration", "ratio", "of", "toehold", "to", "HCR", "hairpins", ...
PMC10968586	In an in vivo model of azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colorectal cancer in C57BL/6 mice, 50 and 100 mg/kg OLE reduced the incidence of colonic neoplasms, and levels of proliferation regulators NF-κB subunit p65, phosphorylated form of signal transducer and activator of transcription 3 (STAT3), ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11499381	We also included an antibody against HA to detect the HA-tag on CLR and CTR to ensure the co-expression of RAMP1 with each GPCR; this analysis supplemented the analysis of myc detection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525028	Moreover, the Asn level was also reduced after paliperidone and AG-401 treatments (Figure 6K).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "Asn", "level",...
PMC11521786	A TUNEL reagent set was used to detect DNA fragmentation, following the manufacturer’s recommendations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "TUNEL", "reagent", "set", "was", "used", "t...
PMC11774251	HaCaT cells at over 60% confluence in a 96-well plate were treated with varying concentrations of Tan-I. The wells were supplemented with CCK8 solution (Dojindo, Kumamoto, Japan) and kept in darkness at 37°C for a 40-minute period.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11317131	Yarnall et al. described the PASTE system that uses single pegRNA PE and a fusion of wildtype Bxb1 integrase to the Cas9 nickase and reverse transcriptase (34).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In fibrosis driving cells analysis, ASXL1 MF patients showed comparable mesenchymal stromal cells (MSCs) derived myofibroblasts while increased monocyte derived fibrocytes in BM compared with ASXL1 MF patients (Figure 1F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8623816	In this study, we used absolute logFC > 1 and FDR < 0.05 to define DEGs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "used", ...
PMC9504875	TRIM25 ∆N (deletion of aa 1–360) could still bind to N protein, although TRIM25 ∆C (deletion of aa 361–630) lost the binding capacity to N protein (Figure 3D, lanes 2 and 4), indicating that the C-terminal region (aa 361–630) of TRIM25 is necessary for binding with N protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This abstract was previously submitted to the American Society of Clinical Oncology (ASCO) Annual Meeting, June 3–7, 2022, and is submitted on behalf of the original authors with their permission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In addition, patients undergoing HSCT are at a high risk of severe morbidity and mortality associated with COVID-19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "patients",...
PMC11367146	ex G.Don (Syn.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "ex", "G.Don", "(", "Syn", "." ] } ]
PMC6442998	Verteporfin, a YAP/TEAD interaction inhibitor, reduced by 90% the viability of both GIST882 and GIST48 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "Verteporfin", ",", "a...
PMC11576293	Refer to Supplementary Material A1 for more details.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Refer", "to", "Supplementary", "Material", "A1", "for", "more", "details", "." ] } ]
PMC10898159	Video Abstract Video AbstractImatinib resistance is the major obstacle for the cure of GIST, mostly due to second mutations within KIT gene for its reactivation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11565047	Data quality control was performed using FastQC and MultiQC , before and after the data were cleaned of adaptor content and low-quality reads using Trim_Galore/Cutadapt on default parameters .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706776	GW542573X and doxycycline were purchased from Tocris (Bristol, United Kingdom) and Sigma-Aldrich, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GW542573X", "and", "doxycycline", "were", "purcha...
PMC2614415	We also observed by SAM analysis Aurora-A to be overexpressed 2.3 fold in carcinomas pretreated with chemotherapy relative to adenomas.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "observed", ...
PMC11306331	above which nearly all 3xFUS condensates were dissolved under blue light, regardless of their 3xFUS expression level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "above", "which", "nearly", "all", "3xF...
PMC11703992	The role of CD4+ Memory T cells in giant cell arteritis has not been elucidated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "role", "of", "CD4", "+", "Memory", "T", ...
PMC5308810	Here, we investigated whether such a dynamic cell state transition occurred in OVC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "investigated", "whether", "such", "a", "dynam...
PMC9503669	The effect of concanamycin A on Nef-mediated MHC-I downregulation was observed at sub-nanomolar concentrations and was specific to MHC-I without effects on CD4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11607764	Mutation information of PTBP1 in different tumors of TCGA in the cBioPortal website. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutation", "information", "of", "PTBP1", "in", "different", "tumors", ...
PMC11461833	Overexpression of lamin A and progerin via the pCAG-3HA plasmid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overexpression", "of", "lamin", "A", "and", "progerin", "via", "the", "pCAG-3HA", "plasmid", ...
PMC10578720	Lower: The frequencies of IFN-γ HBV-specific CD8 T cells of different groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lower", ":", "The", "frequencies", "of", "IFN-γ", "HBV-specific", "CD8", ...
PMC11786704	Quantification result of (J). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "result", "of", "(", "J", ")", ".", "(" ] } ]
PMC11089031	A The positively associated of CDK3 with ZNF692.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "The", "positively", "associated", "of", "CDK3", "with", "ZNF692", "." ] } ]
PMC11551844	As shown by Ramanjooloo et al., (2023), anticancer jaspamide is the main constituent of JDE and JDH extracts and its content was 36.15 ± 0.73% and 0.60 ± 0.16%, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11395280	RPMI 1640 was purchased from Clontech (San Jose, CA, USA), heat-inactivated fetal bovine serum was purchased from R&D Systems (Minneapolis, MN, USA), and ionomycin from Millipore Sigma (Burlington, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012012	SLAMF3/CD229 was expressed in 20% of BL cases, 52% non-GC-DLBCL, 60% FL, 66% GC-DLBCL, 70% CLL, 70% MCL, 82% nodal MZL, 86% mucosa-associated lymphoid tissue (MALT) lymphoma, and 87% splenic MZL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Thirty-five percent of the patients had HLA-haploidentical donors, 62.5% had HLA-identical sibling donors, and 2.5% had matched unrelated donors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thirty-...
PMC11763126	Moreover, TRPM3 overexpression in ccRCC promotes EMT and tumor angiogenesis, facilitating cancer invasion and metastasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "TRPM3", "overexpression", "in", ...
PMC10538569	Our findings have important implications for HIV-1 antibody-based immunotherapies as they demonstrate a viral inhibitory effect that extends beyond the transduced CD4+ T cells to iDCs which can enhance HIV-1 replication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10178190	The murine adipocyte progenitor 3T3-L1 and the human and murine MSC lines HS-5 and MS-5, respectively, were maintained under the same conditions.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC9429973	Co1 pts received RUX 10 mg BID plus POM 0.5 mg QD, while POM was intended to be increased in co2 to 1 and 2 mg QD after 3 and 6 28-day-cycles, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11777207	We found that both the extracellular and intracellular domains of CD80 were necessary for interactions with PD-L1 and that mutation of either of these domains attenuated migration of DCs in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8481254	Cells were treated with d-glucose or l-glucose (Sigma, St Louis, MO, USA) at a final concentration from 5.5 to 55 mM, CA (Sigma, St. Louis, MO, USA) at a final concentration of 0–160 μM, Senexin B (MCE, Shanghai, China) at a final concentration of 80 nM, and CHX (Sigma) at a final concentration of 50 μg/ml.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11297139	Beads were washed with TSE I buffer (0.1% SDS, 1% Triton X-100, 2 mM EDTA, 20 mM Tris-HCl (pH 8.1) and 150 mM NaCl), TSE II buffer (0.1% SDS, 1% Triton X-100, 2 mM EDTA, 20 mM Tris-HCl (pH 8.1) and 500 mM NaCl), buffer III (0.25 M LiCl, 1% NP-40, 1% deoxycholate, 10 mM Tris-HCl (pH 8.1) and 1 mM EDTA), three times TE b...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5417661	We conclude that NOV202 suppresses cell proliferation of various cancer cell lines of different tissue origin at low nanomolar concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "conclude", "that", ...
PMC11597167	The centroid of the X-ray ligand was defined as the grid box.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "centroid", "of", "the", "X-ray", "ligand", "was", "defined", "as", ...
PMC6114978	To further validate the reversal in expression of MST1 and MST2 seen with treatment with TSA, we treated with a different HDAC inhibitor, N-(2-Aminophenyl)-4- [N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide (MS-275) in the same above three lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5417661	The nominal dose was 10 and 30 mg/kg for IV and PO administration, respectively, and the actual concentration was determined to be 9.5 and 28.6 mg/kg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7342409	In this study, the drug concentration gradient method was used to establish the imatinib-resistant GIST (GIST882-ir cell line) from the imatinib-sensitive GIST882 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "...
PMC11727907	These dynamics confirm that PKM2 plays a pivotal role in the modulation of RPE metabolism and redox balance and could explain the mechanisms through which IGF-1 participates in the pathogenesis of retinal diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11047729	Another study also indicated the induction of apoptosis by curcumin in cells from the HL-60 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Another", "study", "also", "indicated", ...
PMC8540692	Also, the treatment with CCM did not alter the methylation level of the analyzed sequence in any of the tested cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ...
PMC11767817	The changes in the expression levels of stress-related proteins in treated and untreated cells were analyzed using a proteome profiler, a membrane-based antibody array employing a sandwich immunoassay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394112	Mice with no detectable signal by the fourth-week post-injection were scored ‘ungrafted’.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mice", "with", "no", "detectable", "signal", "by", "the", "fourt...
PMC11281366	Among the 222 cellular genes for which expression was either upregulated (188) or downregulated (34) (Figure S2), we identified, through a systematic literature search, several candidates that could have either positive or negative effects on HIV-1 replication or persistence (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612626	Pretreatment of E.G7-Ova cells with each compound maintained cell viability, whereas compound A was the most effective and increased MHC-I–SIINFEKL presentation by six-fold (Supplementary Fig. S4A and S4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This leads to great variability in transfusion strategies causing patients to often be over- or undertransfused.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "leads", "to", "great", "variability", "in", ...
PMC11674146	The colonies formed were observed and photographed and the number was hereafter quantified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "colonies", "formed", "were", "observed", "and", "photographed", "and...
PMC5811757	In comparison to the ZFNs and TALENs technologies that require protein–DNA interactions to recognize the target sequence, locus targeting by CRISPR/Cas9 system acts through RNA-DNA interactions and since the synthesis of RNA and its entry into the cell is easier than protein domains, designing and reprogramming CRISPR/...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: The NMA suggested a significant improvement in PFS for zanubrutinib over acalabrutinib (HR = 0.52, 95% CrI [0.30, 0.90]), ibrutinib (0.47, [0.29, 0.76]), and BR (0.13, [0.06, 0.26]).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	RNA-seq corroborated the involvement of USP43 in HIF signalling, with USP43 as one of only two DUBs that is upregulated in hypoxia in an HIF-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742231	Precision medicine aims to address this challenge by tailoring treatments to individual patients, but early prediction methods often fall short due to their reliance on limited data sets, such as genetic information or protein expression levels, which do not fully capture the intricate biology of cancer [1–3].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720107	Therefore, we can conclude that our findings are consistent with the current state of knowledge on the impact of garlic extracts on SOD and CAT expression and activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697065	Here, we sought to survey a larger panel of cell lines expressing a diverse set of antibody-based biotherapeutics to understand host cell genetic adaptations that occur in the setting of high titre secretion and in response to different antibody formats.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6901583	The involvement of VEGFA in angiogenesis has been shown by research, and angiogenesis is an intricate pathway vital to tumorigenesis as well as metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11621565	Numerous studies highlight the inflammatory effect of the LPS at the level of the intestinal barrier, causing permeabilization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Numerous", "studies", "highlight", ...
PMC11509224	Ceylonamides G–I (206–208, Figure 16) are diterpene alkaloids from an Indonesian marine sponge of Spongia sp. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ceylonamides", "G", ...
PMC9429973	200mg QD was selected as the RP2D.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "200", "mg", "QD", "was", "selected", "as", "the", "RP2D", "." ] } ]
PMC11731614	Control mice were fed a regular diet (RD) of 11% fat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Control", "mice", "were", "fed", "a", "regular", "diet", "(", ...

PMC11762280

DSF disulfiram.

[ { "tags": [ "O", "O", "O" ], "tokens": [ "DSF", "disulfiram", "." ] } ]

PMC8658661

At the same time, plasma proteins such as ceruloplasmin (CP) and hemopexin (HPX) were detected in trace amounts or were not found at all in HepG2 cells .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11064533

Δffp and its complementation, i.e., Δffp + pBAD33 ffp had no significant impact on adhesion.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Δffp", "and", "its", "complementation", ",", ...

PMC11484188

For comparisons between two groups, two-tailed unpaired Student's t test was employed.

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PMC11781181

SJS and TEN are severe, life-threatening mucocutaneous reactions characterized by widespread keratinocyte death, blisters, and mucosal sloughing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SJS", "and", "TEN", "a...

PMC9429973

Breakthrough hemolysis events were infrequent: 5/128 patients (3.9%); no event was considered free C5-related.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Breakthrough", "hemolysis", "events", ...

PMC9429973

The adjusted mean difference in maximum percentage reduction in serum tryptase comparing avapritinib to BAT was -69.8% (95% CI: -89.4%, -50.2%; P<0.001).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6892818

Our study provides the first systematic investigation of the effects of CD40 ligation in RCC cells as well as compared these effects to normal (HRPT) cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...

PMC10040136

All experiments were repeated at least thrice.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "repeated", "at", "least", "thrice", "." ] } ]

PMC10698968

The choice to use the osteosarcoma cell line 143B as reference to compare this new MFS cell line was dictated by three major points: i) each of soft tissue sarcomas (STSs) subtype has distinct features that make it unique and difficult to compare with other STSs; ii) 143B cell line has been extensively studied and char...

[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

All the pts were infused with more than 2 x10 CD34+ cells /kg (median number of 2.7 (2.2 -3.4)) without any manipulation of the graft.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10033453

Cytotoxicity measured by MTS (Promega).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytotoxicity", "measured", "by", "MTS", "(", "Promega", ")", "." ] } ]

PMC11087766

For example, PhiKZ PicA-sfGFP localized into a single punctum at the nuclear periphery during PhiKZ infection (Fig. 2H) but is diffuse in uninfected cells (Fig. 2K).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11655498

Zp and Rp are heavily methylated and silenced in latent infection, whereas histone acetylation of Zp and Rp enhances gene accessibility and promotes the binding of transcription factors during lytic replication (Speck et al., 1997; Miller et al., 2007; Woellmer and Hammerschmidt, 2013; Daskalogianni et al., 2015; Guo a...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11698348

Furthermore, Elf5 is recognised as an important suppressor of EMT and inhibitor of metastasis in breast cancer .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "Elf5", "is", "reco...

PMC11277157

We identified a small set of genes that was substantially downregulated along with the KD of DJ-1 (57 genes).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "identified", ...

PMC9429973

Of 7 pts who experienced 13 thromboembolic events, timing of the events relative to splenectomy was known for 6 pts, and in all 6 pts, the thromboembolic events occurred after splenectomy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11721096

The ligand fishing strategies were established utilizing the recombinant cell to screen compounds from complex natural product systems efficiently and accurately.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ligand", "...

PMC9429973

A. Mori, M. Onozawa, S. Tsukamoto, T. Ishio, E. Yokoyama, K. Izumiyama, M. Saito, H. Muraki, M. Morioka, T. Teshima, T. Kondo Blood Disorders Center, Aiiku Hospital; Department of Hematology, Hokkaido University Faculty of Medicine; Sapporo Clinical Laboratory Inc.; Division of Laboratory, Aiiku Hospital, Sapporo, Japa...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Results: The study included 109 patients with SCD and 19,3% of them (21 patients) required neuroimaging.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "The", ...

PMC11449273

Previously, using various carcinoma cell lines we showed that plakoglobin interacted with wild-type and several endogenous p53 mutants (e.g., R280K, R273H, S241F, S215R, R175H) and restored their tumor suppressor activities in vitro.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11380329

Furthermore, such co-supplementation with vitamin D inhibits predominately the proliferative activity of cell population with the French propolis type as manifested by Ki67 expression, while it reduces considerably its expression, particularly with the German type, followed by the Egyptian one.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10823017

Following treatment, the invasive cells of the lower chamber were stained with crystal violet and the photographs were taken with 1X resolution using a microscope.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11594641

We speculated whether the difference in the Rab27A levels translates to various functions of melanoma cells.

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PMC11264242

EGR1 is a direct target of SS18-SSX (de Bruijn et al., 2006; Lubieniecka et al., 2008) and its transcription level is negatively correlated with SS18-SSX activity in synovial sarcoma cells (Su et al., 2010; Laporte et al., 2016).

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PMC10203589

There is a positive correlation between the exonic region of IgII,IgIII and Igii-Igiii linker and the ligand-binding reaction (194).

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PMC8973725

The relative expression level of ZNF677 mRNA and protein in the ccRCC 786–0 cell line was clearly decreased compared with the immortalized human proximal tubular cell line HK-2 cells evaluated by qPCR and Western blot.

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PMC11672881

These findings indicate that the combination induces cytotoxicity in melanoma cells driven by mitochondrial ROS generation and apoptosis induction through the mitochondrial pathway.

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PMC8345486

The increase in apoptosis was accompanied with a proportional increase in the compound accumulation (Figure S4, Supplementary Materials).

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PMC11621565

The data were normalized to GAPDH.

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PMC10213179

In brief, after the chip was equilibrated with 10 mM HEPES and 150 mM NaCl (pH 7.4), the surfaces of the flow cells were activated for 10 min with a 1:1 mixture of 0.1 M NHS (N-hydroxysuccinimide) and 0.4 M EDC (3-(N,N-dimethylamino) propyl-N-ethylcarbodiimide) at a flow rate of 10 μL/min and at a temperature of 37°C.

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PMC9429973

Mitochondria were evaluated by flow cytometry and transmission electron microscopy.

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PMC7504302

The human CDKN2A gene encodes two distinct tumor suppressor proteins resulting from translation of the common second exon in alternative reading frames (ARFs), namely, alpha and beta.

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PMC10237474

As in (A), but with protein 6 with a C-terminal His6 tag expressed from CHO-K1, HEK293S GnTI and Expi293F GnTI stable pools.

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PMC11128598

One such effect is the production of ROS, that we previously observed in ovarian cancer cell lines (3) and have also been reported in other tumor types (44–47).

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PMC11469524

Afterwards we probe the network for superfluous or missing links and repeat the procedure for every step-wise development of the network.

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PMC11615743

T/H indicates the concentration ratio of toehold to HCR hairpins.

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PMC10968586

In an in vivo model of azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colorectal cancer in C57BL/6 mice, 50 and 100 mg/kg OLE reduced the incidence of colonic neoplasms, and levels of proliferation regulators NF-κB subunit p65, phosphorylated form of signal transducer and activator of transcription 3 (STAT3), ...

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PMC11499381

We also included an antibody against HA to detect the HA-tag on CLR and CTR to ensure the co-expression of RAMP1 with each GPCR; this analysis supplemented the analysis of myc detection.

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PMC11525028

Moreover, the Asn level was also reduced after paliperidone and AG-401 treatments (Figure 6K).

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PMC11521786

A TUNEL reagent set was used to detect DNA fragmentation, following the manufacturer’s recommendations.

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PMC11774251

HaCaT cells at over 60% confluence in a 96-well plate were treated with varying concentrations of Tan-I. The wells were supplemented with CCK8 solution (Dojindo, Kumamoto, Japan) and kept in darkness at 37°C for a 40-minute period.

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PMC11317131

Yarnall et al. described the PASTE system that uses single pegRNA PE and a fusion of wildtype Bxb1 integrase to the Cas9 nickase and reverse transcriptase (34).

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PMC9429973

In fibrosis driving cells analysis, ASXL1 MF patients showed comparable mesenchymal stromal cells (MSCs) derived myofibroblasts while increased monocyte derived fibrocytes in BM compared with ASXL1 MF patients (Figure 1F).

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PMC8623816

In this study, we used absolute logFC > 1 and FDR < 0.05 to define DEGs.

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PMC9504875

TRIM25 ∆N (deletion of aa 1–360) could still bind to N protein, although TRIM25 ∆C (deletion of aa 361–630) lost the binding capacity to N protein (Figure 3D, lanes 2 and 4), indicating that the C-terminal region (aa 361–630) of TRIM25 is necessary for binding with N protein.

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PMC9429973

This abstract was previously submitted to the American Society of Clinical Oncology (ASCO) Annual Meeting, June 3–7, 2022, and is submitted on behalf of the original authors with their permission.

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PMC9429973

In addition, patients undergoing HSCT are at a high risk of severe morbidity and mortality associated with COVID-19.

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PMC11367146

ex G.Don (Syn.

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PMC6442998

Verteporfin, a YAP/TEAD interaction inhibitor, reduced by 90% the viability of both GIST882 and GIST48 cells.

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PMC11576293

Refer to Supplementary Material A1 for more details.

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PMC10898159

Video Abstract Video AbstractImatinib resistance is the major obstacle for the cure of GIST, mostly due to second mutations within KIT gene for its reactivation.

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PMC11565047

Data quality control was performed using FastQC and MultiQC , before and after the data were cleaned of adaptor content and low-quality reads using Trim_Galore/Cutadapt on default parameters .

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PMC11706776

GW542573X and doxycycline were purchased from Tocris (Bristol, United Kingdom) and Sigma-Aldrich, respectively.

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PMC2614415

We also observed by SAM analysis Aurora-A to be overexpressed 2.3 fold in carcinomas pretreated with chemotherapy relative to adenomas.

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PMC11306331

above which nearly all 3xFUS condensates were dissolved under blue light, regardless of their 3xFUS expression level.

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PMC11703992

The role of CD4+ Memory T cells in giant cell arteritis has not been elucidated.

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PMC5308810

Here, we investigated whether such a dynamic cell state transition occurred in OVC.

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PMC9503669

The effect of concanamycin A on Nef-mediated MHC-I downregulation was observed at sub-nanomolar concentrations and was specific to MHC-I without effects on CD4.

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PMC11607764

Mutation information of PTBP1 in different tumors of TCGA in the cBioPortal website. (

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PMC11461833

Overexpression of lamin A and progerin via the pCAG-3HA plasmid.

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PMC10578720

Lower: The frequencies of IFN-γ HBV-specific CD8 T cells of different groups.

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PMC11786704

Quantification result of (J). (

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PMC11089031

A The positively associated of CDK3 with ZNF692.

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PMC11551844

As shown by Ramanjooloo et al., (2023), anticancer jaspamide is the main constituent of JDE and JDH extracts and its content was 36.15 ± 0.73% and 0.60 ± 0.16%, respectively.

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PMC11395280

RPMI 1640 was purchased from Clontech (San Jose, CA, USA), heat-inactivated fetal bovine serum was purchased from R&D Systems (Minneapolis, MN, USA), and ionomycin from Millipore Sigma (Burlington, MA, USA).

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PMC11012012

SLAMF3/CD229 was expressed in 20% of BL cases, 52% non-GC-DLBCL, 60% FL, 66% GC-DLBCL, 70% CLL, 70% MCL, 82% nodal MZL, 86% mucosa-associated lymphoid tissue (MALT) lymphoma, and 87% splenic MZL.

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PMC9429973

Thirty-five percent of the patients had HLA-haploidentical donors, 62.5% had HLA-identical sibling donors, and 2.5% had matched unrelated donors.

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PMC11763126

Moreover, TRPM3 overexpression in ccRCC promotes EMT and tumor angiogenesis, facilitating cancer invasion and metastasis .

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PMC10538569

Our findings have important implications for HIV-1 antibody-based immunotherapies as they demonstrate a viral inhibitory effect that extends beyond the transduced CD4+ T cells to iDCs which can enhance HIV-1 replication.

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PMC10178190

The murine adipocyte progenitor 3T3-L1 and the human and murine MSC lines HS-5 and MS-5, respectively, were maintained under the same conditions.

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PMC9429973

Co1 pts received RUX 10 mg BID plus POM 0.5 mg QD, while POM was intended to be increased in co2 to 1 and 2 mg QD after 3 and 6 28-day-cycles, respectively.

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PMC11777207

We found that both the extracellular and intracellular domains of CD80 were necessary for interactions with PD-L1 and that mutation of either of these domains attenuated migration of DCs in vitro.

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PMC8481254

Cells were treated with d-glucose or l-glucose (Sigma, St Louis, MO, USA) at a final concentration from 5.5 to 55 mM, CA (Sigma, St. Louis, MO, USA) at a final concentration of 0–160 μM, Senexin B (MCE, Shanghai, China) at a final concentration of 80 nM, and CHX (Sigma) at a final concentration of 50 μg/ml.

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PMC11297139

Beads were washed with TSE I buffer (0.1% SDS, 1% Triton X-100, 2 mM EDTA, 20 mM Tris-HCl (pH 8.1) and 150 mM NaCl), TSE II buffer (0.1% SDS, 1% Triton X-100, 2 mM EDTA, 20 mM Tris-HCl (pH 8.1) and 500 mM NaCl), buffer III (0.25 M LiCl, 1% NP-40, 1% deoxycholate, 10 mM Tris-HCl (pH 8.1) and 1 mM EDTA), three times TE b...

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PMC5417661

We conclude that NOV202 suppresses cell proliferation of various cancer cell lines of different tissue origin at low nanomolar concentrations.

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PMC11597167

The centroid of the X-ray ligand was defined as the grid box.

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PMC6114978

To further validate the reversal in expression of MST1 and MST2 seen with treatment with TSA, we treated with a different HDAC inhibitor, N-(2-Aminophenyl)-4- [N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide (MS-275) in the same above three lines.

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PMC5417661

The nominal dose was 10 and 30 mg/kg for IV and PO administration, respectively, and the actual concentration was determined to be 9.5 and 28.6 mg/kg.

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PMC7342409

In this study, the drug concentration gradient method was used to establish the imatinib-resistant GIST (GIST882-ir cell line) from the imatinib-sensitive GIST882 cell line.

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PMC11727907

These dynamics confirm that PKM2 plays a pivotal role in the modulation of RPE metabolism and redox balance and could explain the mechanisms through which IGF-1 participates in the pathogenesis of retinal diseases.

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PMC11047729

Another study also indicated the induction of apoptosis by curcumin in cells from the HL-60 cell line.

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PMC8540692

Also, the treatment with CCM did not alter the methylation level of the analyzed sequence in any of the tested cell lines.

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PMC11767817

The changes in the expression levels of stress-related proteins in treated and untreated cells were analyzed using a proteome profiler, a membrane-based antibody array employing a sandwich immunoassay.

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PMC11394112

Mice with no detectable signal by the fourth-week post-injection were scored ‘ungrafted’.

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PMC11281366

Among the 222 cellular genes for which expression was either upregulated (188) or downregulated (34) (Figure S2), we identified, through a systematic literature search, several candidates that could have either positive or negative effects on HIV-1 replication or persistence (Figure 2A).

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PMC11612626

Pretreatment of E.G7-Ova cells with each compound maintained cell viability, whereas compound A was the most effective and increased MHC-I–SIINFEKL presentation by six-fold (Supplementary Fig. S4A and S4B).

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PMC9429973

This leads to great variability in transfusion strategies causing patients to often be over- or undertransfused.

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PMC11674146

The colonies formed were observed and photographed and the number was hereafter quantified.

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PMC5811757

In comparison to the ZFNs and TALENs technologies that require protein–DNA interactions to recognize the target sequence, locus targeting by CRISPR/Cas9 system acts through RNA-DNA interactions and since the synthesis of RNA and its entry into the cell is easier than protein domains, designing and reprogramming CRISPR/...

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PMC9429973

Results: The NMA suggested a significant improvement in PFS for zanubrutinib over acalabrutinib (HR = 0.52, 95% CrI [0.30, 0.90]), ibrutinib (0.47, [0.29, 0.76]), and BR (0.13, [0.06, 0.26]).

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PMC11377827

RNA-seq corroborated the involvement of USP43 in HIF signalling, with USP43 as one of only two DUBs that is upregulated in hypoxia in an HIF-dependent manner.

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PMC11742231

Precision medicine aims to address this challenge by tailoring treatments to individual patients, but early prediction methods often fall short due to their reliance on limited data sets, such as genetic information or protein expression levels, which do not fully capture the intricate biology of cancer [1–3].

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PMC11720107

Therefore, we can conclude that our findings are consistent with the current state of knowledge on the impact of garlic extracts on SOD and CAT expression and activity.

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PMC11697065

Here, we sought to survey a larger panel of cell lines expressing a diverse set of antibody-based biotherapeutics to understand host cell genetic adaptations that occur in the setting of high titre secretion and in response to different antibody formats.

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PMC6901583

The involvement of VEGFA in angiogenesis has been shown by research, and angiogenesis is an intricate pathway vital to tumorigenesis as well as metastasis.

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PMC11621565

Numerous studies highlight the inflammatory effect of the LPS at the level of the intestinal barrier, causing permeabilization.

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PMC11509224

Ceylonamides G–I (206–208, Figure 16) are diterpene alkaloids from an Indonesian marine sponge of Spongia sp. .

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PMC9429973

200mg QD was selected as the RP2D.

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PMC11731614

Control mice were fed a regular diet (RD) of 11% fat.

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