PMCID
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PMC11678448
According to relevant reports, the mortality rate of pasteurellosis in lambs can be as high as 50% .
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PMC11740207
Additionally, the adhesion molecule CD44, which is involved in cell interaction and migration, may contribute to phagocytosis when exposed on ABs (Poon et al., 2014).
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PMC9261184
Ship-side methane emissions associated with loading and unloading included any emissions associated with connecting the loading arms, as well as methane slip and venting emissions.
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PMC9428827
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
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PMC11754784
d Simulated kinetic curve of different species in DNP2-based computation.
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PMC8143558
Saponins interact with membranes in various ways, a characteristic which enables them to disturb the normal interactions between microorganisms and the cells of the human body.
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PMC11342785
The strongest of these synMAPs, DDX4-CORE, had a MT-bundling activity (EC50 = 1.47 μM) within 3-fold of WT and outperformed many native bundling-competent TPPP truncations.
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PMC7342409
Detection of the apoptosis level was by flow cytometry with the annexin V Kit.
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PMC11360263
The morphological heterogeneity included blastomeres and blastocytes, multinucleated cells, mesenchymal cells, cellular connections between HMECs, OECs, and PECs, as well as atypical morphologies.
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PMC11499955
The cocktail of the four TMPP-mAbs, TRZ-H33, CTX-H24, DUR-H15 and BVZ-H6 was thus incubated on tissue sections and the abundance of each released TMPP-tag was determined by MS after addition of DBCO (Fig. 5).
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PMC11474209
Cell cycle arrest after DNA damage is brought on by the CDK inhibitor p21, the main downstream gene that activates p53 targets.
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PMC11770130
The SVF cells were differentiated into adipocytes with a growth medium containing 5 µg/mL insulin, 0.5 mM isobutylmethylxanthine, 1 µM rosiglitazone, 1 µM dexamethasone for two days initially.
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PMC7757104
Similarly to these results, previous studies have demonstrated that tOPN expression was induced in human hepatocellular carcinoma cells resistant to CDDP compared with non-resistant cells (11), in colorectal cancer cells resistant to oxaliplatin (13) and in glioma cells resistant to temozolomide (TMZ) and CDDP (15) and...
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PMC11310713
Scale bars, 1 cm. (
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PMC11597167
Compared to quercetin (IC50: 3.16 ± 0.30 mM) as the reference as well as the test compound, the most effective compound was EGCG with an IC50 value of 1.62 ± 0.12 mM, followed by rosmarinic acid (IC50: 4.06 ± 0.68 mM).
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PMC9917080
In the treatment of brain cancer, the problem of using sorafenib is exacerbated due to the presence of the blood–brain barrier, which requires the use of even higher concentrations of this anticancer agent, compared with the treatment of cancer of other organs.
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PMC9429973
NAbs significantly increased in all patients (p<0.001) at levels ≥50%, even though 12 patients had levels of <30% after the first dose.
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PMC11437637
This study was retrospectively registered by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University (approval number K2023-578).Endometrial carcinoma (EC) is one of the main malignancies of the female reproductive system and most patients seek medical attention for clinical symptoms such ...
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PMC2196094
The very low level of c-kit was unexpected.
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PMC9429973
Despite the immunocompromised status of the participants, the study vaccines induced serotype-specific immunogenicity and V114 induced generally comparable responses to PCV13 by IgG GMCs and OPA for the 13 shared serotypes at Day 90.
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PMC10006224
Cohesin-STAG1 binds at/near CTCF sites while cohesin-STAG2 is loaded elsewhere and requires NIPBL to reach them.
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PMC9368503
Proteomic profiles of ICR-SS-1 and the other two synovial sarcoma cell lines were compared by a two-tailed t-test in Perseus.
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PMC11552389
Differences observed in FOXN3 localization in drug-sensitive and drug-resistant melanoma cells via immunofluorescent staining.
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PMC4816271
Here, we describe a GD2-targeting CAR retroviral cassette, which has been optimized for CAR T-cell persistence, efficacy and safety.
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PMC11723947
The whiskers go from the minimum to the lower quartile and from the upper quartile to the maximum.
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PMC11661040
H-J) Western blot analysis confirmed that the overexpression of CGREF1 resulted in an upregulation of Cyclin D expression.
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PMC9014716
P-gp expression is significantly higher in liver cancer tissue than normal liver tissue, thus inhibition or down-regulation of P-gp could strengthen the sensitivity of hepatoma cells to chemotherapy drugs.
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PMC9429973
Median duration of V1 was 13 (range 11-29) months for all pts and 14 (range 13-26) months in the 9 pts with a MRD-guided discontinuation strategy who achieved uMRD, one pt failed to achieve uMRD in bone marrow and had to stop after approximately 2.5 years as per protocol.
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PMC11750712
We recently described a targeting strategy based on the mutually exclusive expression of T cell antigen receptor beta-chain constant domain (TRBC) 1 and 2.
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PMC11487720
The cold shock alone had no apparent effect.
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PMC9429973
Baseline characteristics were generally balanced, whereas more patients in the TP53 group had Karnofsky performance score <90 (57% versus 40%; P=0.04).
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PMC10538569
Infected B-1 cells then migrate into the lymph node to spread infection through virological synapses (42).
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PMC9429973
Median follow-up was 23 months (0-170) (20 for GCV and 30 for C, p=0.124).
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PMC5311252
To rank the predictions, we used the number of algorithms predicting the same target, ranging from targets predicted by a single algorithm (2154 mRNAs) to all nine (only 2 mRNAs) (Supplementary Figure 1b).
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PMC11697703
We found a significantly increased percentage of brains with clusters of heterotopic neurons in the deep layers or the white matter after electroporation of miR-193b alone and miRs-193b and -365 compared to scrambled controls (heterotopy+ brains: 83.3% miR-193b, 80% miR-193b-miR-365; 0% scrambled-miRNA; Figures 3A–3F).
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PMC9119314
Compounds 3–6 were also active against the emerging zoonotic species P. knowlesi with 5 being the most potent (IC50 = 0.11 µM).
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PMC11747949
For transwell assay Thermo Scientific, Nunc Polycarbonate Cell Culture Inserts in Multi‐Well Plates, 0.4 µm, 12‐well (#140652) were used.
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PMC6133382
Plates were blocked in PBS + 2.5% BSA blocking buffer for 90 minutes and then washed 4 times with PBS containing 0.05% Tween-20 (Sigma).
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PMC11092382
The hERG channel plays a pivotal role in modulating the repolarization phase of cardiac action potentials by precisely regulating the rapid delayed rectifier K current (I kr ).
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PMC11139449
The CHO-K1 cell line and clone of CHO-CASP8AP2 manipulated cells were assessed for viability using the MTT method (sodium butyrate was utilized at concentrations of 2.5, 5, 10, 25, 50, and 100 mM).
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PMC9429973
Aims: We report the final results of the observational MOZOBL06877 study (NCT03406091; partially supported by Sanofi investigation funds) to prospectively assess the performance of HSC mobilization with G-CSF/CY plus on-demand CXCR4 inhibitor plerixafor (PLX) in NDMM pts treated with novel agents.
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PMC8916024
Proteobacteria and Verrucomicrobia were the two dominant phyla in all samples, and overall relative abundances was 48.2% and 14.2%, respectively.
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PMC11087055
See also Video 4 and Figure 4—source data 1.
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PMC8009078
It is reported that almost intact RoG variation explain the folding of the protein during the MD simulation.
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PMC10395663
The corrected Figure 1 is presented below.
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PMC9960565
The MTT assay that measures the metabolic activity of cells was used for cytotoxicity evaluation after 72 h of cell culture.
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PMC4369959
An inverse association between the consumption of fruits and vegetables and cancer risk was evident by an epidemiological study in Netherlands.
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PMC10522430
The resultant pellets were freeze-dried to yield the GACP extract.
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PMC11746942
HaCaT cells were placed into six-well plates.
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PMC11469524
Shown are phosphorylations of Raf1 at serine 338 (activatory site) and 289/296/301 (ERK feedback sites) as well as of ERK and p38 in Burkitt lymphoma cells BL-2, BL-41 and CA-46.
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PMC4659567
This work aimed to prepare and study the in vitro cytotoxicity and basic mechanistic aspects of half-sandwich organometallic dichloridoruthenium(II) complexes of the general formula [Ru(η -p-cym)(naza)Cl2] containing 7-azaindole or its derivatives (naza) as monodentate N-donor ligands.
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PMC11792740
Variations in T-cell- depletion between patients may lead to differences in immunotherapy efficacy.
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PMC9688728
According to the results obtained from the search against KEGG, the pentose phosphate pathway contains 22 metabolites, nine of which were detected in the presented dataset.
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PMC9822769
18S rRNA was used as the reference gene.
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PMC11361748
Images were captured using a Zeiss LSM800 confocal microscope.
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PMC11592008
Correspondingly, cleaved GSDMD was detected in the lysates of treated PKs (Figure 3A).
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PMC9429973
53.8% revealed D dimer values ranging from100-5000 ng/ml with 13.6% having values greater than 5000ng/ml.
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PMC8973085
It is conspicuous that the efficiency was minimized in other compounds which do not include such structural functional moieties in their structural skeleton.
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PMC11387401
Interestingly, selenium deficiency has been negatively correlated with survival for those living with an HIV-1 infection (Baum et al, 1997), and the levels of host selenoproteins decrease during an HIV infection (Gladyshev et al, 1999; Guillin et al, 2022).
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PMC9096373
The samples were deparaffinized using xylene, rehydrated with a gradient alcohol series, and treated with 500 W microwave using 10 mM citrate buffer (pH 6.0) twice for 5 minutes each time.
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PMC11569208
After 6 h, media containing siRNA was replaced with DMEM supplemented with 1% (v/v) penicillin-streptomycin (Gibco), 30mM HEPES buffer and 10% (v/v) serum composed of 3-parts HyClone newborn calf serum (Thermo Fisher, cat.
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PMC11476222
This involved the optimization of an LC-MS method alongside ganglioside extraction techniques.
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PMC10978090
In both patients, the complete kinetics of anti-PF4/H antibodies were monitored by EIA and HIPA pre- and postoperatively.
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PMC9429973
Magrolimab will be administered intravenously as an initial priming dose to mitigate on-target anemia, followed by a maintenance dose on days 8, 15, 22, and 29 during cycle 1 (35 days); days 1, 8, 15, and 22 during cycle 2 (28 days); and days 1 and 15 from cycle 3 (28 days) onward (maximum of 8 cycles in patients who p...
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PMC11748618
We assess the combined impact of these variants on CHD1L regulation using publicly available sequencing studies, and test the relationship between CHD1L expression and set-point viral load using imputed CHD1L expression from monocytes.
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PMC11790971
The biexponential fluorescence decay curve fitting using LMA can be represented by the following formula:5[12pt] $$I(t)=_ ^_}}+_ ^_}}+C$$=A1⋅e−tτ1+A2⋅e−tτ2+Cwhere is the fluorescence intensity at time .
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PMC11721064
In addition, CK10 expression showed the lowest level at P0-P3 SKCs.
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PMC11670407
m-p Western blot results and semiquantitative analysis of the band density for 143B and U2OS cells treated with different concentrations of cisplatin for 24 h or with different durations of treatment with 10 μM cisplatin.
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PMC8567602
The comparison of either combination genotype or fusion-only tumor to Smarcb1-loss–alone tumor BAF-family peak lengths had P values below the detectable value.)
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PMC11063646
Furthermore, they also facilitate solubilization and partitioning of lipophilic actives into the skin layers.
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PMC10818573
The RPA-LFA rapid EBV detection system established in this study is simple to operate, does not require expensive equipment, and allows for rapid visualization, which is important for the quality management of cell banks.
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PMC11684297
Turbidity of the amyloid sample also decreases if the amyloid gets degraded.
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PMC11361748
Data reported as mean ± SEM.
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PMC9429973
Methods: Adult BCP-ALL patients (n=565) were treated according to pediatric inspired protocols of the German Acute Lymphoblastic Leukemia Study group (GMALL) and profiled for integrative analyses by RNA-Seq (n=565), SNP-arrays (n=115), whole exome sequencing (WES; n=84) and whole genome sequencing (WGS; n=3).
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PMC11549062
Scar bar 10 μm. **
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PMC11742047
In particular, the over-expression of LPCAT3 is related to poor prognosis of AML patients, due to its involvement in ferroptosis.
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PMC8409415
The human ovarian carcinoma cell lines OVISE, OVTOKO, and RMG‐I were purchased from the Japanese Collection of Research Bioresources Cell Bank (Osaka, Japan).
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PMC9429973
F. Morschhauser, Y. Jiang, F. Jardin, A. F. Herrera, L. H. Sehn, C. Herbaux, C. Flowers, T. Phillips, A. López Guillermo, C. Diefenbach, G. P. Gregory, A. Kim, A. M. Barbui, S. Balasubramanian, W. Harris, J. Hirata, J. N. Paulson, C. Lee, G. Lenz Lille University Hospital Center, Lille Cedex, France; Genentech, Inc., S...
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PMC9341513
Note that the hg19 reference genome was used in this study, as some data sets were only available mapped to this reference; because our simulations do not depend on the precise underlying sequence, none of our conclusions would be altered by using a more recent genome build, such as GRCh38.
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PMC9429973
M. Charfi, G. Abichou, F. Kallel, I. Ben amor, L. Khelifa, I. Frikha, Y. Fakhfekh, O. Kassar, M. Medhaffar, S. Hdiji, M. Elloumi hematology department, university hospital hedi chaker sfax, sfax, Tunisia Background: Refractory/relapsed (RR) disease is the main cause of morbidity and mortality in Diffuse Large B cell Ly...
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PMC8469018
The cell lysates were centrifuged at 800 g at 4 °C for 10 min, the obtained sediment was a nuclear fraction.
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PMC9429973
Methods: Pax5 mice backcrossed to the C57BL/6J background (N10) were infected with LCMV.
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PMC11363012
This was consistent with bulk RNA-seq data taken at time points after flower opening (Figure S19 and Supporting Information Data 6).
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PMC11791203
Exogenous reactive oxygen species (ROS) or ROS-inducing agents also influence apoptosis by upregulating death receptors, leading to full activation of caspases.
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PMC11323699
It is a thrilling discovery that introduces novel pharmacological avenues, although the precise mechanisms underlying this synergy remain to be identified.
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PMC8584666
All patients had prostate cancer with a Gleason score of 8 or higher and were classified in the high-risk group according to the National Comprehensive Cancer Network (NCCN) risk classification.
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PMC11726183
TOF HRMS (m/z): [M + H], calcd 357.1351, found: 357.1351. %
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PMC11640115
First, to show the utility of the imGPS, correlations between its components (CRP, ALB, and lymphocyte count) and the therapeutic effect of pembrolizumab were investigated.
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PMC8658661
Based on the meta-analysis of articles, we have summarized the recommendations for the use of the HepG2 cell line (Table 3).
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PMC11323699
b CD8 (green point) and CD4 (blue square) staining were quantified at baseline (upper panels) or post NACT (lower panels) in the CD47 (left panels) and CD47 (right panels) populations.
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PMC10362265
The complex formed with the ectromelia decoy was slightly more compact than the rest, displaying an average radius of 20.5 Å (Fig. S2a, green line).
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PMC11477621
The solvent was evaporated under reduced pressure and diluted with H2O (20 mL).
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PMC11488203
To prove effective washing of MSC before incubation of the cells with serumfree medium for EV/exosome production, EVs were isolated in a control experiment from the third washing step.
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PMC5673955
The upstream, downstream, and enzymatic properties of the studied enzyme were described in 18, 19.
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PMC11354239
51-2092KZ; 0.8 μL/well).
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PMC9429973
The differences of overall survival of the patients with R/R CLL treated with ibrutinib in the third line depending on gender were non significant Image: Summary/Conclusion: Chronic Lymphocytic Leukemia is the most common type of leukemia in the western countries and with the median age at the diagnosis of 72 years old...
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PMC3675084
Western blot analysis of the PARP, caspase-2, and caspase-3 after BPR0L075 (10–100 nM) treatment for 24 hours in the OVCAR-3/OVCAR-3-TR cells (A) and SKOV-3/SKOV-3-TR cells (B).
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PMC11021472
D-F) Same as (A–C) in DG75 cells. (
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PMC9622879
As discussed in “Introduction” section, in a prosumer-centric CEMS, each prosumer is first allowed to optimize their own optimization problem without energy trading.
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PMC11774112
The data are expressed as the means ± SDs (n= 3). *
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