OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11637276	Finally, α2β1 integrin and MAP3K1 were significantly up-regulated in pancreatic tumours compared to healthy tissue and high expression of these genes correlated with reduced survival of pancreatic cancer patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11252553	The percentage of apoptotic lymphocytes as a function of radiation dose (both times in the presence and absence of Taurine and cysteine) has been separately plotted in Figure 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9479186	All experiments were performed in triplicate independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "performed", "in", "triplicate", "independent", "experiments", "." ] } ]
PMC8864075	As reported, TFAE of S. baicalensis has an inhibitory effect on NSCLC (Wang et al., 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "reported", ",", ...
PMC11628904	Larval zebrafish have been widely adopted to investigate the mechanisms of tissue repair and regeneration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Larval", "zebrafish", "have", "been", "widely", "adopted", ...
PMC4005030	The compound was found to be potent antioxidant, antibacterial, anticancer, antihyperlipidemic, antidiabetic, and anti-inflammatory.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "compound", "was", "found",...
PMC10419319	In the A2780 xenograft model, cisplatin treatment dramatically reduced tumor volume (Figure 5B) and tumor weight (Figure 5C) compared with the control group.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9512971	Considering the adherence of the target patient population, we assumed that qid administration of camostat mesilate (morning, midday, evening, and before bedtime) would be acceptable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11507371	Nearly all cancer cells show imbalances in antioxidant enzyme levels compared to non-malignant cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nearly", "all", "cancer", "cells", "show", "imbalances", "in", "...
PMC9429973	Image: Summary/Conclusion: Major changes in 2L Tx patterns were observed in pts with RRMM between 2012 and 2020 with the decreased use of single class regimens and the increased use of combination Tx.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9516401	The insulin-degrading enzyme (IDE) is responsible for degrading insulin and is a potential drug target for T2DM treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "insulin-degrading", "...
PMC7081114	The PCR primers used have the following sequences: KIF21B forward, 5ʹ-GGATGCCACAGATGAGTT-3ʹ and reverse, 5ʹ-TGTCCCGTAACCAAGTTC-3ʹ; GAPDH forward, 5ʹ-TGACTTCAACAGCGACACCCA-3ʹ and reverse, 5ʹ-CACCCTGTTGCTGTAGCCAAA-3ʹ. PCR amplification was quantitated using the 2 method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Secondary endpoints include hematologic and molecular responses, safety, acceptability, and palatability of asciminib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondary", "endpoints", "include", "hematologic", "and", ...
PMC11738017	Inset numbers in the circle (MM cell) represent the relative the degree of T-cell–mediated cytotoxicity, ranging from low (1×) to high (5×). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11033180	F, F′) Higher magnification of the boxed regions in E, E′ illustrates the pericellular Plexin A1 labeling. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", ",", "F′", ...
PMC11264242	By contrast, treatment with FK228 or PP2 alone did not significantly alter SYO-1 and Yamato-SS cell migration behavior (Figure 4B and Supplementary Figure S13A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11190062	A cytotoxic effect has also been proposed to be partly due to reduced NF-κB signaling and reduced degradation of pro-apoptotic BCL-2 family members (37, 38).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8913139	The relative expression of miR-448 and ROCK1 was calculated by the 2 method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relative", "expression", "of", "miR-448", "and", "ROCK1", "was", ...
PMC11388384	This experimental finding was directly at odds with the central premise of the classic hindered diffusion model (1, 34).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "expe...
PMC9351137	Scale bar = 5 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "5", "μm", "." ] } ]
PMC11401358	AFM characterization of (GAGSGA)2 after treatment with H2O2. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AFM", "characterization", "of", "(GAGSGA)2", "after", "treatment", "with", "H2O2", ".", "(" ] } ]
PMC11332076	Scale bar: 20 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "20", "μm", "." ] } ]
PMC11345828	Rac-18:H NMR (400 MHz, DMSO-d6) δ 7.75 (d, J = 8.4 Hz, 1H), 7.31–7.28 (m, 1H), 6.99 (s, 0.5H), 6.73–6.34 (m, 3.5H), 4.68–4.63 (m, 0.5H), 4.31–4.26 (m, 0.5H), 4.23–4.11 (m, 1H), 4.06 (s, 1H), 4.02–3.92 (m, 4H), 3.88 (s, 2H), 3.87 (s, 1H), 3.78 (s, 2H), 3.76 (s, 3H), 3.71–3.61 (m, 1H), 3.25–3.15 (m, 3H), 2.24 (s, 6H), 2....	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11335267	Although our data support the involvement of dysfunctional sympathetic innervation of these tissues, the contribution of a developmental defect possibly affecting myogenesis during embryonic development cannot be entirely ruled out, since the importance of the transient expression of Alx3 in previously unrecognized dis...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Within the TP53 aberrant vs the TP53 wt group 48% vs 67% had received 1, 48% vs 33% had received 2 or more prior lines of therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9693627	All samples from one biological replicate were analyzed in one run.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "samples", "from", "one", "biological", "replicate", "were", "analyzed", "in", ...
PMC11538390	Correlation between the regional CP prevalence and allele frequency was calculated and plotted using Pearson’s product-moment correlation in base R (v3.6.1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10719213	A cDNA synthesis of the MT-CO1 mRNA was performed with RT-PCR (5ʹ-TGTAAAACGACGGCCAGTTATACCTATTATTCGGCGC; 5ʹ-CAGGAAACAGCTATGACCC GGGTTCTTCGAATGTGTG), followed by amplicon and next-generation sequencing analysis as described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600592	C NMR (CDCl3) δ 172.03 (C-10), 156.98 (C-7), 135.27 (C-4), 129.19 (C-1), 128.53 (C-2, 6), 126.33 (C-3, 5), 72.90 (C-14), 62.01 (C-21), 31.57 (C-15, 19), 31.20 (C-9), 25.38 (C-8), 23.72 (C-17), 22.38 (C-16, 18).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: TCL Lines demonstrate varying sensitivities to tolinapant with the most sensitive cell line, ALK+ ALCL SUP-M2, having an IC50 as low as 20 nM ± 1 nM while a resistant CTCL cell line HH had an IC50 of over 20 µM. In combination experiments using both cell lines, tolinapant plus azacytidine or decitabine display...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	After depletion of endogenous Fu, RNAi-insensitive Fu was still activated by Hh, underwent maturation, and phosphorylated Ci, albeit with reduced efficiency compared with Fu; however, phosphorylated Ci was trapped in the cytoplasm and failed to activate ptc (fig. S3, E and F), suggesting that Ci phosphorylation by Fu p...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10745221	Whole cell extracts of the 143B-P and 143B-R cells were fractionated onto a sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) gel, and Coomassie staining was performed as a loading control to compare ADMA and SDMA levels between 143B-P and 143B-R cells (Fig 2).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11186948	DNA obtained from whole blood was used for library preparation and exome enrichment with Agilent SureSelect V7 kit according to manufacturer protocol and an indexed 150 bp paired-end sequencing was carried out on Illumina HiSeq3000 instrument at CRS4 NGS facility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699042	Therefore, we exposed newly purchased A-673, MCF-7, and HeLa cells (m0) to the drug library, and then again at two additionally predefined time points after continuous culture (m6 and m12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11640555	In this perspective, canonical treatments including radiotherapy and chemotherapy are strongly limited in treating GBM due to toxicity to healthy brain areas that have more impactful consequences leading to brain damage and decreased quality of life in patients; thus, the development of novel pharmacological targets th...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680578	Error bars represent the mean ± SEM of three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "represent", "the", "mean", "±", "SEM", "of", "three", "independent",...
PMC11748335	Cell lines were routinely tested for mycoplasma and authenticated using short tandem repeat analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "lines", "were", "routinely", "tested", "for", "mycoplasma", ...
PMC11047729	PD has a direct cytotoxic influence on telomerase through a decrease in hTERT expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PD", "has", "a", "direct", "cytotoxic", "influence", "on", "telo...
PMC11684269	Cell metabolism is intricately linked to the extracellular milieu, collectively referred to as the cellular microenvironment; this plastic environment provides a venue for nutrient fueling, cellular signaling, cell-cell crosstalk, and dynamic sensing and adaptation to disease context (70–72).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: There is no existing standard of care after patients fail CAR-T therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", "There", "is",...
PMC11394730	The complexity and heterogeneity of cancer metabolism demand multifaceted approaches, and natural products offer a rich source of diverse bioactive compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "compl...
PMC11718109	Fluorescence image of endogenous tdTomato-tagged TH DA neurons (white) plated on one side of the chamber (C), with a representative axon migrating through a microfluidic channel (D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11756514	no. 12309050, Thermo Fisher Scientific).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "no.", "12309050", ",", "Thermo", "Fisher", "Scientific", ")", "." ] } ]
PMC11683240	A–C, PT (10 ng/ml = 0.0000962 μM) and 20 μl of a fraction of the hemofiltrate library or the respective amount of solvent (H2O) were added directly to CHO-K1 cells in FCS-free medium and incubated for 4 h at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Immunosuppressive treatment was started with Cyclophosphamide 100mg and Prednisone 100mg daily.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunosuppressive", "treatment", "was", "started", "with", "Cyclophosphamide", "1...
PMC11629143	ChIP‐qPCR revealed that A‐485 caused a significant (p < 0.05) 3.2‐fold decrease in H3K27ac at the CMV promoter, whereas H3K9ac did not change significantly (p > 0.05) (Figure 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700165	All cells were cultivated at 37 °C in a humidified 5% CO2 incubator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cells", "were", "cultivated", "at", "37", "°", ...
PMC11721064	Beyond the JAK-STAT3 pathway, STAT3 interacts with other signaling cascades, including PI3K/Akt and MAPK, forming a complex network that governs diverse cellular functions [24–26].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615218	These distinct signaling activities of costimulatory domains, at least in part, drive the T cells carrying CARs with the 4-1BB domain towards TCM, whereas the presence of CD28 domains yields TEFF .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7039683	For the Tn5 footprint analysis, we shifted all reads aligned to the plus strand by +4 bp, and all reads aligned to the minus strand by −5 bp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11775197	In comparison, the AMPK agonist metformin inhibits GW501516-induced expression of Glut1 and SLC1A5 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "comparison", ",", "the", "AMPK", "agonist", "metformin", "...
PMC11283030	Noe found that ACLY not only supported tumour-associated macrophages (TAMs) polarization, also suppressed its immune activity, ultimately resulting in tumor growth and progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	A reduction in NRF2 with ALOX15B silencing was apparent via Western analysis, which was rescued with CDDO-Im (Fig. 6B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "reducti...
PMC10772747	The mechanism of the P53 signaling pathway in KEGG breast cancer (Figure 3) starts with DNA damage that activates the P53 gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10747139	Moreover, a good binding affinity with DNA was observed through an intercalative binding mode, which was further confirmed by EB displacement and viscosity-measurement studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11345828	The reaction vessel was charged with toluene (0.4 M) and sparged with argon for 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reaction", "vessel", "was", "ch...
PMC9727330	Additionally, ASNS transcription is also affected negatively by other factors like P53, a tumor suppressor gene (Chiu et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11683240	Additionally, the PTS1 and α1AT signals indicate a colocalization, especially prominent using higher concentrations of α1AT (Fig. S7, indicated by arrows).Figure 7Effect of α1AT on detectable PTS1 signal in CHO-K1 and A549 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: This study shed new light on the molecular mechanism of glucocorticoid-resistant of ITP patients that GR regulated mitochondrial metabolism of MDSCs, which modulated the immunosuppressive functions of MDSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	IL and IH risk groups could not be differentiated neither by aaIPI (5y-OS IL 85% vs IH 82%, p=0.725; 5y-PFS 76% vs 69%, p=0.556) nor NCCN-IPI (5y-OS IL 85% vs IH 70%, p=0.162; 5y-PFS IL 70% vs IH 70%, p=0.905), although in the last index there were no high-risk patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5925824	While LY3300054 bound to human and cynomolgous PD-L1 with similar affinities (EC50 of 0.075 nM and 0.085 nM, respectively) (Fig. 1a, b), LY3300054 did not bind to murine PD-L1 (Fig. 1c); furthermore, LY3300054 did not bind to other proteins of the immunoglobulin superfamily, such as PD-L2, B7–1, B7–2, PD-1, CD28, TIGIT...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Recently Gerstung et al. (Nature Genetics, 2017) developed a knowledge bank (KB)-based algorithm to in order to more precisely predict individual outcomes based on demographic, clinical, and genetic data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11549062	The positive rate of PDGFBB and/or PDGFR‐β was higher in meningioma, and apoptotic cells were also increased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "positive", "rate", "of", "PDGFB...
PMC11247842	The red horizontal line indicates the genome-wide significance level [− log10(p) = 8.5]Table 2Additional novel lead SNPs for QTL identified by multi-trait meta-analysis (MTAG ), along with their functional annotation and nearest geneBTABPQTLrsid− log10(p)AnnotationNearest gene324,114,90423,865,017–24,365,480rs385025933...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10158546	While we observed differences in lag phase measurements between inoculums used, we did not observe any clear clustering of samples that would suggest differences between cell lines or changes over time post-inoculation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8751435	This finding indicates that structural damage of membrane and permeability (detected by intracellular PI) alteration are progressively induced by CME in pyroptotic cell, and this phenomenon may be also attributed to GSDME‐forming membrane pore.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10968586	As the literature analysis in Section 2 and Section 3 corroborates, methodological standardization for the study of the effects of natural products may reveal to be challenging, mainly as a consequence of the combination of the multiplicity of molecular patterns triggered and effects elicited by these substances, toget...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11686380	Original blots/gels of (A) and (B) are presented in Supplementary Figure S2 (A) and (B). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Patients having a LAU ratio above 54.7 are predicted to die from the infection thus close monitoring and early intensive intervention should be offered to these patients to control infection-related complications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	With respect to the background of pan-cancer expressed genes, the top-500 least rewired of the pan-cancer expressed genes (i.e., that are the most similarly wired across different cancers) are significantly enriched in cancer-drivers (with enrichment p value ≈ 1.60 × 10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11407042	Freshly recovered bacterial cells are recommended for cytotoxicity assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Freshly", "recovered", "bacterial", "cells", "are", "recommended", "for", "cytotoxicity", "assays", "." ...
PMC11637276	DMEM, RPMI, OptiMEM, Trypsin-EDTA, TrypLE, and FBS were from Gibco.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DMEM", ",", "RPMI", ",", "OptiMEM", ",", "Trypsin-EDTA", ...
PMC9739791	BODI-Pt showed low toxicity in the dark, although surpassing that of carboplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BODI-Pt", "showed", "low", "toxicity", "in", "the", "dark", ",", "alt...
PMC11564405	These results align with the outcomes of previous bioinformatics analysis, RILPL2 expression was low in tumor cells in NSCLC, low RILPL2 expression demonstrated a substantial association with advanced disease stage and poor prognosis, and RILPL2 expression exhibited a pronounced positive correlation with CD4 + and CD8 ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11695623	Finally, we draw a ROC curve to evaluate the diagnostic value of DCUN1D5 in LUAD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "we", "draw", "a", "ROC", "curve"...
PMC10142392	Intelligent” stimulus-sensitive nanoparticles could improve therapeutic effectiveness by enabling controlled drug delivery to the site of action.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Intelligent", "”", "stimulus-sensitive", "na...
PMC11319300	Arrows indicate the baits.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Arrows", "indicate", "the", "baits", "." ] } ]
PMC11578343	After plasma treatment, a nonionic surfactant solution of 2% v/v Tween‐20 in PBS was incubated in the channel for 5 min to prevent potential biofouling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11281366	CD59 controls the formation of the MAC at the terminal stage of the complement activation common to all known activation pathways , while CD55 prevents the formation of C3 convertases, and C5 and CD46 act as inactivators of C3b and C4b .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11750712	TRBC1 status could be determined either by IHC or using the commercially available CE-marked in vitro diagnostic LymphoTrack Dx TRB Assay (Invivoscribe).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11291490	b duCD40 gene expression levels in duPBMCs were measured by qRT-PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "duCD40", "gene", "expression", "levels", "in", "duPBMCs", "were", "measured", "b...
PMC11703896	FDA had approved the use of rapamycin as an immunosuppressant in organ transplanted patients (Patel et al. 2019; Baroja et al., 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9874064	The above resutls indicated that cisplatin and the USP1i of C527 had a promising prospect for combination therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "above", "resutls", "indicated", ...
PMC11754784	n = 3 from three independent experiments).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "3", "from", "three", "independent", "experiments", ")", "." ] } ]
PMC3915447	Chemicals Cell culture reagents were from Life Technologies, Inc. (Grand Island, NY).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chemicals", "Cell", "culture", "reagents", "were", "fr...
PMC9429973	Often CT scans are reported as showing likely lymphoma, leading to specialty referral before tissue diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Often", "CT", "scans", "are", "reported", "...
PMC10810426	We also determined that induction of quiescence by serum starvation blocked integration at 24 hpi.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "determined", "that", "induction", "of", "quie...
PMC11441402	H2O2 concentration was determined by measuring absorbance at 240 nm and calculated using the extinction coefficient (ɛ = 43.6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H2O2", "concentration",...
PMC11637276	MDA-MB-231 cells were allowed to adhere on biotinylated CDM for 2 h before incubating the cells with 10 μM BTT-3033, an α2 integrin inhibitor, or DMSO for 6 h. Cells were fixed and stained with phalloidin Alexa-Fluor 555, Alexa Fluor 488-streptavidin, and DAPI.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11773391	Compared with treatment with 2 mM TMZ alone, treatment with 2 mM TMZ in combination with 0.5 μM or 1 μM vMF increased the apoptosis rates to 41.37% ± 3.96% and 55.53% ± 5.09%, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Consistent with reduced B cell numbers, splenic B cell proliferation and subsequent generation of antibody-producing plasma cells was significantly lowered after LFPRLR knockdown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11269933	Evaluation of enzyme-substrate binding capacity of PK S11 phosphorylation (A) The time course of RMSD values of the wild type system (black) and the S11-phospho system (red). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	In our study, more than 259 proteins have been found to be downregulated upon STAU1 overexpression (Table S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "stud...
PMC11768281	Advancements in antimalarial treatment have evolved from monotherapy, targeting the parasite with a single drug, to combination therapies that employ multiple mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11092382	and observed that sophocarpine demonstrated the most significant anti-inflammatory effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "and", "observed", "that", "sophocarpine", "demonstrated", "the", "most", "significant", "anti-inflamma...
PMC10810426	Taken together, these data show that cell replication is needed for efficient trafficking of the PIC into the nucleus of NIH3T3 cells but suggest that partially reverse-transcribed replication products can complete replication in the nucleus after cell division finishes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC10957991	Bar 100 um. (	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Bar", "100", "um", ".", "(" ] } ]
PMC10142392	This process is well-known biologically in living cells, where it occurs during the formation of the DNA double helix, the folding of polypeptides, and the arrangement of phospholipids in the cell membrane .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11509224	There have been some reviews on the separation, structural elucidation, and biological activity evaluation of diterpenoids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "have", "been", "some", "revie...
PMC11678841	According to the instructions of the manufacturers, supernatant cytokines levels after 48 h of GA pre-treatment and 12 h of treatment with C. albicans were measured by using an IL-6 ELISA kit (ELK Biotechnology, Twin Helix, Rho, Italy), IL-1α ELISA kit, (Peprotech, Cranbury, NJ, USA), or IL-1β PicoKine ELISA kit (Boste...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11637276

Finally, α2β1 integrin and MAP3K1 were significantly up-regulated in pancreatic tumours compared to healthy tissue and high expression of these genes correlated with reduced survival of pancreatic cancer patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11252553

The percentage of apoptotic lymphocytes as a function of radiation dose (both times in the presence and absence of Taurine and cysteine) has been separately plotted in Figure 4.

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PMC9479186

All experiments were performed in triplicate independent experiments.

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PMC8864075

As reported, TFAE of S. baicalensis has an inhibitory effect on NSCLC (Wang et al., 2016).

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PMC11628904

Larval zebrafish have been widely adopted to investigate the mechanisms of tissue repair and regeneration.

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PMC4005030

The compound was found to be potent antioxidant, antibacterial, anticancer, antihyperlipidemic, antidiabetic, and anti-inflammatory.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "compound", "was", "found",...

PMC10419319

In the A2780 xenograft model, cisplatin treatment dramatically reduced tumor volume (Figure 5B) and tumor weight (Figure 5C) compared with the control group.

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PMC9512971

Considering the adherence of the target patient population, we assumed that qid administration of camostat mesilate (morning, midday, evening, and before bedtime) would be acceptable.

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PMC11507371

Nearly all cancer cells show imbalances in antioxidant enzyme levels compared to non-malignant cells .

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PMC9429973

Image: Summary/Conclusion: Major changes in 2L Tx patterns were observed in pts with RRMM between 2012 and 2020 with the decreased use of single class regimens and the increased use of combination Tx.

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PMC9516401

The insulin-degrading enzyme (IDE) is responsible for degrading insulin and is a potential drug target for T2DM treatment.

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PMC7081114

The PCR primers used have the following sequences: KIF21B forward, 5ʹ-GGATGCCACAGATGAGTT-3ʹ and reverse, 5ʹ-TGTCCCGTAACCAAGTTC-3ʹ; GAPDH forward, 5ʹ-TGACTTCAACAGCGACACCCA-3ʹ and reverse, 5ʹ-CACCCTGTTGCTGTAGCCAAA-3ʹ. PCR amplification was quantitated using the 2 method.

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PMC9429973

Secondary endpoints include hematologic and molecular responses, safety, acceptability, and palatability of asciminib.

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PMC11738017

Inset numbers in the circle (MM cell) represent the relative the degree of T-cell–mediated cytotoxicity, ranging from low (1×) to high (5×). (

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PMC11033180

F, F′) Higher magnification of the boxed regions in E, E′ illustrates the pericellular Plexin A1 labeling. (

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PMC11264242

By contrast, treatment with FK228 or PP2 alone did not significantly alter SYO-1 and Yamato-SS cell migration behavior (Figure 4B and Supplementary Figure S13A).

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PMC11190062

A cytotoxic effect has also been proposed to be partly due to reduced NF-κB signaling and reduced degradation of pro-apoptotic BCL-2 family members (37, 38).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8913139

The relative expression of miR-448 and ROCK1 was calculated by the 2 method.

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PMC11388384

This experimental finding was directly at odds with the central premise of the classic hindered diffusion model (1, 34).

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PMC9351137

Scale bar = 5 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "5", "μm", "." ] } ]

PMC11401358

AFM characterization of (GAGSGA)2 after treatment with H2O2. (

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PMC11332076

Scale bar: 20 μm.

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PMC11345828

Rac-18:H NMR (400 MHz, DMSO-d6) δ 7.75 (d, J = 8.4 Hz, 1H), 7.31–7.28 (m, 1H), 6.99 (s, 0.5H), 6.73–6.34 (m, 3.5H), 4.68–4.63 (m, 0.5H), 4.31–4.26 (m, 0.5H), 4.23–4.11 (m, 1H), 4.06 (s, 1H), 4.02–3.92 (m, 4H), 3.88 (s, 2H), 3.87 (s, 1H), 3.78 (s, 2H), 3.76 (s, 3H), 3.71–3.61 (m, 1H), 3.25–3.15 (m, 3H), 2.24 (s, 6H), 2....

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PMC11335267

Although our data support the involvement of dysfunctional sympathetic innervation of these tissues, the contribution of a developmental defect possibly affecting myogenesis during embryonic development cannot be entirely ruled out, since the importance of the transient expression of Alx3 in previously unrecognized dis...

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PMC9429973

Within the TP53 aberrant vs the TP53 wt group 48% vs 67% had received 1, 48% vs 33% had received 2 or more prior lines of therapy.

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PMC9693627

All samples from one biological replicate were analyzed in one run.

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PMC11538390

Correlation between the regional CP prevalence and allele frequency was calculated and plotted using Pearson’s product-moment correlation in base R (v3.6.1).

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PMC10719213

A cDNA synthesis of the MT-CO1 mRNA was performed with RT-PCR (5ʹ-TGTAAAACGACGGCCAGTTATACCTATTATTCGGCGC; 5ʹ-CAGGAAACAGCTATGACCC GGGTTCTTCGAATGTGTG), followed by amplicon and next-generation sequencing analysis as described .

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PMC6600592

C NMR (CDCl3) δ 172.03 (C-10), 156.98 (C-7), 135.27 (C-4), 129.19 (C-1), 128.53 (C-2, 6), 126.33 (C-3, 5), 72.90 (C-14), 62.01 (C-21), 31.57 (C-15, 19), 31.20 (C-9), 25.38 (C-8), 23.72 (C-17), 22.38 (C-16, 18).

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PMC9429973

Results: TCL Lines demonstrate varying sensitivities to tolinapant with the most sensitive cell line, ALK+ ALCL SUP-M2, having an IC50 as low as 20 nM ± 1 nM while a resistant CTCL cell line HH had an IC50 of over 20 µM. In combination experiments using both cell lines, tolinapant plus azacytidine or decitabine display...

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PMC11721587

After depletion of endogenous Fu, RNAi-insensitive Fu was still activated by Hh, underwent maturation, and phosphorylated Ci, albeit with reduced efficiency compared with Fu; however, phosphorylated Ci was trapped in the cytoplasm and failed to activate ptc (fig. S3, E and F), suggesting that Ci phosphorylation by Fu p...

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PMC10745221

Whole cell extracts of the 143B-P and 143B-R cells were fractionated onto a sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) gel, and Coomassie staining was performed as a loading control to compare ADMA and SDMA levels between 143B-P and 143B-R cells (Fig 2).

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PMC11186948

DNA obtained from whole blood was used for library preparation and exome enrichment with Agilent SureSelect V7 kit according to manufacturer protocol and an indexed 150 bp paired-end sequencing was carried out on Illumina HiSeq3000 instrument at CRS4 NGS facility.

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PMC11699042

Therefore, we exposed newly purchased A-673, MCF-7, and HeLa cells (m0) to the drug library, and then again at two additionally predefined time points after continuous culture (m6 and m12).

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PMC11640555

In this perspective, canonical treatments including radiotherapy and chemotherapy are strongly limited in treating GBM due to toxicity to healthy brain areas that have more impactful consequences leading to brain damage and decreased quality of life in patients; thus, the development of novel pharmacological targets th...

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PMC11680578

Error bars represent the mean ± SEM of three independent experiments.

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PMC11748335

Cell lines were routinely tested for mycoplasma and authenticated using short tandem repeat analysis.

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PMC11047729

PD has a direct cytotoxic influence on telomerase through a decrease in hTERT expression.

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PMC11684269

Cell metabolism is intricately linked to the extracellular milieu, collectively referred to as the cellular microenvironment; this plastic environment provides a venue for nutrient fueling, cellular signaling, cell-cell crosstalk, and dynamic sensing and adaptation to disease context (70–72).

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PMC9429973

Image: Summary/Conclusion: There is no existing standard of care after patients fail CAR-T therapy.

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PMC11394730

The complexity and heterogeneity of cancer metabolism demand multifaceted approaches, and natural products offer a rich source of diverse bioactive compounds.

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PMC11718109

Fluorescence image of endogenous tdTomato-tagged TH DA neurons (white) plated on one side of the chamber (C), with a representative axon migrating through a microfluidic channel (D).

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PMC11756514

no. 12309050, Thermo Fisher Scientific).

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PMC11683240

A–C, PT (10 ng/ml = 0.0000962 μM) and 20 μl of a fraction of the hemofiltrate library or the respective amount of solvent (H2O) were added directly to CHO-K1 cells in FCS-free medium and incubated for 4 h at 37 °C.

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PMC9429973

Immunosuppressive treatment was started with Cyclophosphamide 100mg and Prednisone 100mg daily.

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PMC11629143

ChIP‐qPCR revealed that A‐485 caused a significant (p < 0.05) 3.2‐fold decrease in H3K27ac at the CMV promoter, whereas H3K9ac did not change significantly (p > 0.05) (Figure 2B).

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PMC11700165

All cells were cultivated at 37 °C in a humidified 5% CO2 incubator.

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PMC11721064

Beyond the JAK-STAT3 pathway, STAT3 interacts with other signaling cascades, including PI3K/Akt and MAPK, forming a complex network that governs diverse cellular functions [24–26].

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PMC11615218

These distinct signaling activities of costimulatory domains, at least in part, drive the T cells carrying CARs with the 4-1BB domain towards TCM, whereas the presence of CD28 domains yields TEFF .

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PMC7039683

For the Tn5 footprint analysis, we shifted all reads aligned to the plus strand by +4 bp, and all reads aligned to the minus strand by −5 bp.

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PMC11775197

In comparison, the AMPK agonist metformin inhibits GW501516-induced expression of Glut1 and SLC1A5 .

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PMC11283030

Noe found that ACLY not only supported tumour-associated macrophages (TAMs) polarization, also suppressed its immune activity, ultimately resulting in tumor growth and progression.

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PMC11754432

A reduction in NRF2 with ALOX15B silencing was apparent via Western analysis, which was rescued with CDDO-Im (Fig. 6B).

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PMC10772747

The mechanism of the P53 signaling pathway in KEGG breast cancer (Figure 3) starts with DNA damage that activates the P53 gene.

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PMC10747139

Moreover, a good binding affinity with DNA was observed through an intercalative binding mode, which was further confirmed by EB displacement and viscosity-measurement studies.

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PMC11345828

The reaction vessel was charged with toluene (0.4 M) and sparged with argon for 5 min.

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PMC9727330

Additionally, ASNS transcription is also affected negatively by other factors like P53, a tumor suppressor gene (Chiu et al., 2020).

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PMC11683240

Additionally, the PTS1 and α1AT signals indicate a colocalization, especially prominent using higher concentrations of α1AT (Fig. S7, indicated by arrows).Figure 7Effect of α1AT on detectable PTS1 signal in CHO-K1 and A549 cells.

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PMC9429973

Summary/Conclusion: This study shed new light on the molecular mechanism of glucocorticoid-resistant of ITP patients that GR regulated mitochondrial metabolism of MDSCs, which modulated the immunosuppressive functions of MDSCs.

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PMC9429973

IL and IH risk groups could not be differentiated neither by aaIPI (5y-OS IL 85% vs IH 82%, p=0.725; 5y-PFS 76% vs 69%, p=0.556) nor NCCN-IPI (5y-OS IL 85% vs IH 70%, p=0.162; 5y-PFS IL 70% vs IH 70%, p=0.905), although in the last index there were no high-risk patients.

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PMC5925824

While LY3300054 bound to human and cynomolgous PD-L1 with similar affinities (EC50 of 0.075 nM and 0.085 nM, respectively) (Fig. 1a, b), LY3300054 did not bind to murine PD-L1 (Fig. 1c); furthermore, LY3300054 did not bind to other proteins of the immunoglobulin superfamily, such as PD-L2, B7–1, B7–2, PD-1, CD28, TIGIT...

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PMC9429973

Recently Gerstung et al. (Nature Genetics, 2017) developed a knowledge bank (KB)-based algorithm to in order to more precisely predict individual outcomes based on demographic, clinical, and genetic data.

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PMC11549062

The positive rate of PDGFBB and/or PDGFR‐β was higher in meningioma, and apoptotic cells were also increased.

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PMC11247842

The red horizontal line indicates the genome-wide significance level [− log10(p) = 8.5]Table 2Additional novel lead SNPs for QTL identified by multi-trait meta-analysis (MTAG ), along with their functional annotation and nearest geneBTABPQTLrsid− log10(p)AnnotationNearest gene324,114,90423,865,017–24,365,480rs385025933...

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PMC10158546

While we observed differences in lag phase measurements between inoculums used, we did not observe any clear clustering of samples that would suggest differences between cell lines or changes over time post-inoculation.

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PMC8751435

This finding indicates that structural damage of membrane and permeability (detected by intracellular PI) alteration are progressively induced by CME in pyroptotic cell, and this phenomenon may be also attributed to GSDME‐forming membrane pore.

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PMC10968586

As the literature analysis in Section 2 and Section 3 corroborates, methodological standardization for the study of the effects of natural products may reveal to be challenging, mainly as a consequence of the combination of the multiplicity of molecular patterns triggered and effects elicited by these substances, toget...

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PMC11686380

Original blots/gels of (A) and (B) are presented in Supplementary Figure S2 (A) and (B). (

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PMC9429973

Patients having a LAU ratio above 54.7 are predicted to die from the infection thus close monitoring and early intensive intervention should be offered to these patients to control infection-related complications.

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PMC6379402

With respect to the background of pan-cancer expressed genes, the top-500 least rewired of the pan-cancer expressed genes (i.e., that are the most similarly wired across different cancers) are significantly enriched in cancer-drivers (with enrichment p value ≈ 1.60 × 10).

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PMC11407042

Freshly recovered bacterial cells are recommended for cytotoxicity assays.

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PMC11637276

DMEM, RPMI, OptiMEM, Trypsin-EDTA, TrypLE, and FBS were from Gibco.

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PMC9739791

BODI-Pt showed low toxicity in the dark, although surpassing that of carboplatin.

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PMC11564405

These results align with the outcomes of previous bioinformatics analysis, RILPL2 expression was low in tumor cells in NSCLC, low RILPL2 expression demonstrated a substantial association with advanced disease stage and poor prognosis, and RILPL2 expression exhibited a pronounced positive correlation with CD4 + and CD8 ...

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PMC11695623

Finally, we draw a ROC curve to evaluate the diagnostic value of DCUN1D5 in LUAD.

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PMC10142392

Intelligent” stimulus-sensitive nanoparticles could improve therapeutic effectiveness by enabling controlled drug delivery to the site of action.

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PMC11319300

Arrows indicate the baits.

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PMC11578343

After plasma treatment, a nonionic surfactant solution of 2% v/v Tween‐20 in PBS was incubated in the channel for 5 min to prevent potential biofouling.

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PMC11281366

CD59 controls the formation of the MAC at the terminal stage of the complement activation common to all known activation pathways , while CD55 prevents the formation of C3 convertases, and C5 and CD46 act as inactivators of C3b and C4b .

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PMC11750712

TRBC1 status could be determined either by IHC or using the commercially available CE-marked in vitro diagnostic LymphoTrack Dx TRB Assay (Invivoscribe).

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PMC11291490

b duCD40 gene expression levels in duPBMCs were measured by qRT-PCR.

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PMC11703896

FDA had approved the use of rapamycin as an immunosuppressant in organ transplanted patients (Patel et al. 2019; Baroja et al., 2016).

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PMC9874064

The above resutls indicated that cisplatin and the USP1i of C527 had a promising prospect for combination therapy.

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PMC11754784

n = 3 from three independent experiments).

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PMC3915447

Chemicals Cell culture reagents were from Life Technologies, Inc. (Grand Island, NY).

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PMC9429973

Often CT scans are reported as showing likely lymphoma, leading to specialty referral before tissue diagnosis.

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PMC10810426

We also determined that induction of quiescence by serum starvation blocked integration at 24 hpi.

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PMC11441402

H2O2 concentration was determined by measuring absorbance at 240 nm and calculated using the extinction coefficient (ɛ = 43.6).

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PMC11637276

MDA-MB-231 cells were allowed to adhere on biotinylated CDM for 2 h before incubating the cells with 10 μM BTT-3033, an α2 integrin inhibitor, or DMSO for 6 h. Cells were fixed and stained with phalloidin Alexa-Fluor 555, Alexa Fluor 488-streptavidin, and DAPI.

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PMC11773391

Compared with treatment with 2 mM TMZ alone, treatment with 2 mM TMZ in combination with 0.5 μM or 1 μM vMF increased the apoptosis rates to 41.37% ± 3.96% and 55.53% ± 5.09%, respectively.

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PMC9429973

Consistent with reduced B cell numbers, splenic B cell proliferation and subsequent generation of antibody-producing plasma cells was significantly lowered after LFPRLR knockdown.

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PMC11269933

Evaluation of enzyme-substrate binding capacity of PK S11 phosphorylation (A) The time course of RMSD values of the wild type system (black) and the S11-phospho system (red). (

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PMC11194678

In our study, more than 259 proteins have been found to be downregulated upon STAU1 overexpression (Table S2).

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PMC11768281

Advancements in antimalarial treatment have evolved from monotherapy, targeting the parasite with a single drug, to combination therapies that employ multiple mechanisms.

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PMC11092382

and observed that sophocarpine demonstrated the most significant anti-inflammatory effect.

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PMC10810426

Taken together, these data show that cell replication is needed for efficient trafficking of the PIC into the nucleus of NIH3T3 cells but suggest that partially reverse-transcribed replication products can complete replication in the nucleus after cell division finishes.

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PMC10957991

Bar 100 um. (

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PMC10142392

This process is well-known biologically in living cells, where it occurs during the formation of the DNA double helix, the folding of polypeptides, and the arrangement of phospholipids in the cell membrane .

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PMC11509224

There have been some reviews on the separation, structural elucidation, and biological activity evaluation of diterpenoids.

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PMC11678841

According to the instructions of the manufacturers, supernatant cytokines levels after 48 h of GA pre-treatment and 12 h of treatment with C. albicans were measured by using an IL-6 ELISA kit (ELK Biotechnology, Twin Helix, Rho, Italy), IL-1α ELISA kit, (Peprotech, Cranbury, NJ, USA), or IL-1β PicoKine ELISA kit (Boste...

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