OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10847511	Mutational signature 3 were significantly higher in samples with HR-related gene alterations the those without (Mann-Whitney test, P = 0.037).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutatio...
PMC10421378	Caco-2 cell cultures with TEER values ≥ 600 Ω × cm were used in the bacteria adhesion experiments.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Caco-2", "cell", "cultures", "with"...
PMC11682224	Data were presented as mean ± standard deviation and analyzed using t-tests for two-group comparisons and one-way ANOVA for multiple-group comparisons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "p...
PMC8806312	In summary, a 4-gene-based risk model may serve as a marker for predicting prognosis and correlates with immune infiltration in OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "summar...
PMC3203927	The cell seeding density was 50,000 cells/cm for both 2D and 3D cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "seeding", "density", "was", "50,000", "cells/cm", "for", ...
PMC11286266	Biotinylation was conducted in vivo, where cells were co-transfected with a BirA-encoding plasmid (biotin ligase, UK2969) in a 1:0.06 ratio.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10604092	In fact, patients with cancer cachexia have increased resting energy expenditure, increased protein degradation and lipolysis, and decreased protein synthesis compared with healthy individuals .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11759751	The flow diagram of group therapy of B-NHL tail vein transplanted tumor mice constructed by Raji-Luc cells (A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "The", "flow", "diag...
PMC11297139	At post 4 days of spheroid formation, the volume of spheroid formed by LLPS-positive cells was larger than that of spheroid formed by negative cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11297139	We targeted cREs of previously reported EWS/FLI1 induced genes where chromatin accessibility is regulated by ARID1A LLPS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "targeted", "cREs", "of", "previously", ...
PMC6642070	The underlying mechanism of SAMS remains elusive, although several hypotheses have been proposed and extensively reviewed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "underlying", "mechanism", "of", "SAMS", ...
PMC11739504	Scale bar: 2 μm (e) Graphs showed fluorescence intensity of IFT25 and IFT52 under serum starvation 6 h, 24 h in stable Kat2b KO NIH3Te and control NIH3T3. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742290	Several LGR5 inhibitors have been identified in the literature, including 4-AAQB which negatively regulated the stem cell maintenance via the LGR5/WNT/β-catenin signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9583612	This top-down measurement needs to be scaled by the typical frequency and duration of events on the site to make a direct comparison to the annualized inventory.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9672323	These anti-cancer effects of NSAIDs are probably due to their anti-inflammatory actions, the ability to induce apoptosis in tumor cells, impair angiogenesis, and enhance T cell-dependent cellular immune responses, probably by suppressing PGE2 synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730311	This highlights that the relationship between the length of the fatty acid and potency is complex and highly dependent on the specific lipidated peptide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	The development of mild or moderate cGVHD was associated with a better overall survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "development", "of", "mild", "or", "moderate", "cGVHD", "w...
PMC7192625	The tendencies observed for cross-ChAs for H3K9me3 are already present in the randomized networks, suggesting that 3D interactions might not have a strong effect on cross-ChAs estimations, apart from the cross-occurrence with H3K27me3, a mark heavily involved in 3D interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The most often mutations are 4bp insertions in exon 12, affecting 2 functionally important tryptophan residues (W288 and W290) in the C-terminal region of nucleophosmin and causing a frameshift.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8998437	While only trace amounts of the CCR3 and CCR5 transcripts were found, and low levels of CCR2 mRNA expression were detected in type III BL cell lines and LCLs, CCR1 mRNA expression was high in all three LCLs and in all two type III BL cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10999934	The cells were placed in a 6-well plate and grown until they reached 50% confluenc.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "placed", "in", "a", "6-w...
PMC11461025	Lane 1: control cells (DMSO), Lane 2: 25 μM of isoginkgetin, Lane 3: 50 μM of isoginkgetin, Lane 4: 75 μM of isoginkgetin, Lane 5: 100 μM of isoginkgetin, Lane 6: 1 μM of staurosporine. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	of carfilzomib for > 1 year, leading to the outgrowth of clones with acquired carfilzomib resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "of", "carfilzomib", "for", ">", "1", "year"...
PMC11740207	These cells exhibited symmetric division (SD) capabilities, the ability to initiate and drive disease progression, and cytological and morphological similarities to LSCs (Lapidot et al., 1994; Bonnet and Dick, 1997; Guan et al., 2003).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11247842	Enrichment analysis one of the methods to provide additional biological meaning to GWAS results, with statistical support.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enrichment", "analysis", "one", "of", ...
PMC8009078	A report suggests that M. alba juice and its fractions may inhibit internalization and replication of murine norovirus-1 (MNV-1), whereas it may influence adherence or internalization of feline calicivirus-F9 (FCV-F9) virions .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401358	SF, GCTS, HA, COL, GEL, SA, HPMC, GUM and GSH (1 mg/mL) were incubated with 100 mM H2O2 at 37 °C for 1 h, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2777936	Additionally, while WNT5A mRNA levels were higher than that of other Wnt ligands, as assessed by real-time RT-PCR assays, it is not known if this relates to appreciably higher levels of Wnt protein or activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11732635	All cell processing steps are operated and double-checked by skilled technicians in good manufacturing practice (GMP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cell", "processing", "steps", "...
PMC11122631	The H NMR spectrum (Table 1) of 1 revealed resonant signals corresponding to a terminal methyl group [δH 0.88 (H-20)], two acetyl methyl groups (δH 2.09 and 2.04), a methoxy group (δH 3.70), an oxymethine [δH 5.75 (H-4)], and seven olefinic methines [δH 5.84 (H-5), 6.35 (H-6), 7.39 (H-7), 6.55 (H-10), 7.48 (H-11), 6.77...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11733919	Increased levels of lysosomes were also observed upon MNP@CD26 and MNP@CD26@17D treatment using the analysis of fluorescence signals of lysosomal marker Lamp1 fused to green fluorescence protein (GFP) (Figure 3e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11576293	See Supplementary Material A1 for more details.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "See", "Supplementary", "Material", "A1", "for", "more", "details", "." ] } ]
PMC11782508	Each 20 µL PCR reaction mixture contained: 10 µL of Master-mix, 1 µM each of the forward and reverse primers (azuF and azuR), 1 µL of template DNA (50–100 ng/µL), and nuclease-free water to reach the final volume.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473750	We have defined increased MYCN protein stability as a necessary feature during MYCN-related tumorigenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "defined", "increased", "MYCN", "protein", "stability", ...
PMC11528603	Therefore, our finding suggested that SA-EA might, beside apoptotic death, hinder HL60 cells proliferation via p21 signaling pathway as well as decrease PCNA-dependent DNA replication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median OS was 130 days for R/R patients and 269 days for treatment-naïve patients; median DFS was 199 days for treatment-naïve patients and 145 days for R/R cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3164356	Thus, this genome sequence of the ancestral K1 cell line should not be considered as completely representative of all CHO cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens"...
PMC11705484	Quantitative ultra‐performance liquid chromatography/mass spectrometry analysis confirmed these results (Figure 1G–J).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantitative", "ultra‐performance", "liquid", "chromatography/mass", "s...
PMC11224020	In DCs confined at a height of 3 μm, most actin was found in a cloud located on the top of nuclei (Fig. 3b).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7812570	In contrast, the cotransduction of GPI-m36.4 had no obvious effect on the expression of the P24 antigen, which was released into the cell culture medium at high levels when a control vector was cotransfected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11126803	Hence, a comprehensive understanding of the mechanisms of RCC progression and angiogenesis is required to develop better therapeutic strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "a", "com...
PMC11772585	G MMP was measured by flow cytometry (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", "MMP", "was", "measured", "by", "flow", "cytometry", "(", "n", "=", ...
PMC9429973	Lower GAS5 expression on diagnosis was related to an adverse prognosis, since higher levels of lactate dehydrogenase was detected in the GAS5low group compared to the GAS5high group (p < 0.01).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Therefore the aim of this study was to characterise the neoantigen burden (NAB) in DLBCL by COO subtype as well as elucidate the relationship between NAB, tumour microenvironment and disease pathogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11400680	As a training result, our prompt detector achieved mAP50 up to 0.855 showing 0.965 for the cell class and 0.745 for the nucleus class.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11782508	(d) ¹H NMR spectrum obtained at 500 MHz.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "(", "d", ")", "¹H", "NMR", "spectrum", "obtained", "at", "500", "MHz", "." ] } ]
PMC11544122	These data suggest that in addition to the β-arrestin and SNX9/18 modes for GPCR endocytosis, additional modes exist.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "suggest", "that"...
PMC11765678	Membranes were incubated with a primary antibody overnight at 4 °C and diluted in EveryBlot Blocking Reagent: rabbit anti-GADPH (Novus, NBP2-20859; 1:1000), mouse anti-Pgp (Santa Cruz Biotechnology, TX, USA; 1:200), and rabbit anti-BCRP (Abcam, 1:1000).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7987994	In this case, the degradation is expected and required and some conditions for in vitro testing stated in the standard might be too stringent leading to nonrelevant results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543853	Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "information", "on", "research", "desig...
PMC11342785	However, this approach did not produce the large-scale MT bundles observed in vitro and in the oligodendrocyte cytoskeleton.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "this", "approach"...
PMC5839394	Furthermore, the production of other metal nanoparticles embedded in this EPS has already been reported [21–25].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "produc...
PMC5025404	Transfection was performed in a similar manner as described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfection", "was", "performed", "in", "a", "similar", "manner", "as", "described", "above", ...
PMC11693599	CD109 is known to promote stemness properties, such as sphere-forming ability, drug resistance, tumor initiation, metastasis, and epithelial-to-mesenchymal transition, in various cancer cells (17-20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11547972	Controls remained untreated.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Controls", "remained", "untreated", "." ] } ]
PMC5925824	Anti-CD20 antibody rituximab (wild type IgG1) was tested as a positive control in the same assay against the CD20-positive WIL2-S cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "token...
PMC10706275	Over 60 successive passages, monoclonal cell lines were produced that consistently expressed all relevant external proteins without discernible variation in expression levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Over", ...
PMC11469524	An increase in MEK and ERK phosphorylation as early as 2 min after α-IgM-mediated BCR stimulation is observed in the presence of the p38 inhibitor SB203580.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11594588	The MitoXpress Xtra probe provides a powerful tool for the detailed investigation of this most critical of biological parameters like the analysis the concentration of molecular oxygen within the cell monolayer; a real-time assessment of transient changes in cell respiration, concentration, and consumption; hypoxia and...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657744	Our results suggest that CEP89 and FBF1 are critical for timely ciliary disassembly, which is necessary for proper cell cycle progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "resul...
PMC7823217	Bioprinted breast, brain, skin, colorectal, pancreatic, and other cancer models were highly successful in mimicking tumour anatomy, physiology, and molecular biology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11506670	Further, mutations in NRAS are linked to poorer survival and outcomes compared to both KRAS-mutant and wild-type mCRC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", ",", "mutations", "in",...
PMC11791264	However, others have noted an oncogenic role for SETD7 in prostate cancer (28), hepatocellular carcinoma (29), and intestinal tumorigenesis (30).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5833712	d Representative Western blot and e densitometric analysis of PARP1 cleavage in A2780cis cells transfected with non-specific or SIRT1 and KDM6B-specific siRNAs after 24 h treatment with 40 μM of cisplatin alone or in combination with 10 nM of KB9520.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10926885	Dynein cell light intermediate chain 1 (DYNC1LI1) influences the sensitivity of colorectal cancer to radiation and chemotherapy and is linked to pancreatic ductal adenocarcinoma, hepatocellular carcinoma and prostate cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7192625	H3K36me3 was the mark with the least increased ChAs in the PP subnetwork compared to distance preserving randomization, showing a moderate impact of 3D interactions in the preferential contacts established between regions with the mark.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670954	Collectively, these data demonstrate that Y-27632 synergizes with BA to alleviate the decreased in the expression and abnormal localization of ZO-1 and Occludin, indicating that the RhoA/ROCK2/MLCK signaling pathway may be involved in the protective effects of BA on tight junction proteins. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6803987	What is worth reminding is that in the high-dose group (80 mg/mL) these were more significant improvement compared with 3TC (20 mg/mL), and it also had a more significant liver-protecting effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8557138	Subsequent, binding of VEGF-A to its cognate receptor VEGFR2 on the endothelial cells (EC) of the neighboring blood vessels induces the expression of genes involved in EC proliferation and migration (Stacker and Achen 2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10944868	On the other hand, blood-Brain Barrier (BBB) property is crucial for the effectiveness of drugs in treating central nervous system disorders.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8469018	At any tested concentrations of drug, we did not observe the inhibition of cell cycle in the G1 phase, which is typical for DHODH inhibition .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9351137	Indeed, chromosome segregation defects during mitosis produce aneuploidy which lead to chromosomal instability, a principal contributor to genetic heterogeneity in cancer and an important determinant of clinical prognosis and therapeutic resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11469524	Data was generated by pre-treating BL-2 cells with inhibitors targeting key effectors downstream of BCR for 3h with subsequent BCR stimulation using α-IgM for 30 min (upper panel) or no stimulation as consistency check (lower panel).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190062	Here, we show that inhibiting the lysosomal degradation pathway by HCQ treatment had a potentiating effect on carfilzomib-induced cytotoxicity and that HCQ treatment reduced the protective effect of LPS and CpG stimulation on PI-induced cytotoxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10852540	Source: elaborated by the authors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Source", ":", "elaborated", "by", "the", "authors", "." ] } ]
PMC11772585	Furthermore, we observed that ATF4 overexpression increased the proliferation of cSCC cells in vivo, as evidenced by elevated levels of PCNA protein (Fig. 7E, F) and mRNA (Fig. 7G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635519	The lentiviral vector pLJM1 with the human CMV promoter and a green fluorescent protein (GFP) as an N-terminal tag with a puromycin selection marker was used for selecting the infected cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	RBD45 was insufficient to initiate LLPS; instead, a condensed liquid phase robustly formed for STAU1 fragments containing RBD23 (e.g., WT, RBD2345, RBD23).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543885	Decant and wash twice with freshly prepared quencher buffer, each wash lasting 1 min.14.Immediately decant the final wash and fix the cells with 4% (wt/vol) paraformaldehyde (PFA), followed by permeabilization and blocking as described above.15.After blocking, incubate the cells with 100 μL diluted anti-NLRP3 or anti-f...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	U. Platzbecker, E. Angelucci, P. Montesinos, R. M. Lemoli, A. Spyridonidis, J. Casariego, T. I. Mughal, M. Mohty Medical Clinic and Policlinic of Hematology, Cell Therapy and Hemostaseology, University Hospital Leipzig, Leipzig, Germany; Hematology and Cellular Therapy Unit, IRCCS Ospedale Policlinico San Martino, Geno...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	A “skew” parameter is calculated to indicate the relative contribution of kinase‐centric versus substrate‐centric evidence to the INKA score (equation (4)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The thrombotic complications are more frequent in severe form of COVID-19 patients who associated lymphopenia, group 1-28.22% vs group 2- 13.12%, Chi-squared 10.03, p=0.001, thrombosis was an important covariate in Cox proportional hazard regression, Wald 6.72, p=0.01 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9516447	In agreement with previous studies that HA15 and YUM70 at the concentrations used did not affect the viability of normal cells , both HA15 and YUM70 treatment showed minimal toxicity in the normal human bronchial epithelial cell line BEAS-2B (Supp.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9019892	Therefore, we next investigated whether FGFR‐mediated reactivation of the MAPK pathway can attenuate the antiproliferative effect of nintedanib in GISTs (Fig. 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8777939	Tissue samples isolated from an orthotopic xenograft model were used for histological analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tissue", "samples", "isolated", "from", "an", "orthotopic", "xenograft", "m...
PMC7553912	The kidney was minced into fine pieces and digested with collagenase type II (Sigma) dissolved in Dulbecco's modified Eagle's medium (DMEM; Invitrogen, Carlsbad, CA) supplemented with 2% fetal calf serum (FCS) using a gentleMACS Dissociator (Miltenyi Biotec, Bergisch Gladbach, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5600151	Their architecture, which can be controlled by different synthesis processes, allows the control of characteristics such as shape, size, charge, and solubility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6803987	IV (8.0 g) was further separated by RP-18 column chromatography, and gradient elution was carried out (0% ~ 100%, MeOH-H2O) to obtain a total of 29 fractions of Fr.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9065483	Inhibition of the EGFR pathway abrogates vanadate-enhanced viral infectivity (A) Human 786-0 renal carcinoma cells were pre-treated with or without vanadate (150 μM) and varying concentrations of gefitinib (0–50 μM) as indicated for 4 h. Cells were then treated with 10 ng/mL EGF for 10 min and lysates were probed by we...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", ...
PMC9429973	Two patients without humoral and T cell responses contracted COVID-19, emphasizing the need for vaccination against SARS-CoV2 in order to protect this highly vulnerable population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11741906	For example, miRNA's expression profiling in the SGC -7901 line resistant to 5-fluorouracil revealed that hsa-miR-133b upregulation occurring upon resistance acquisition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8540692	Thus, the data suggest that ROS generation may be responsible for the observed increase in the apoptotic cell number in CCM and NaBu-treated GBM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11591038	PS1/2 γ-secretase-mediated cleavage of the APP generates AICD, which functions as a transcriptional activator to induce Hif1a gene expression; on the other hand, PS1/2 itself, in a γ-secretase-independent manner, increases PHD2 activity to promote HIF-1α degradation in vitro .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: RNA-seq was applied to RNA samples from FFPE blocks of DLBCL patients, 4 of whom were previously classified as GCB and the remaining 4 as ABC, based on NanoString-LST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10728535	Regarding the fact that several molecular mechanisms such as decreased drug uptake and increased drug efflux are involved in cancer drug resistance, we focused on membrane ion channels, pumps, and transmembrane proteins as well as their regulators in obtained DEGs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306019	For this study, we primarily used the first three principal components (PC1, PC2, and PC3), which account for 71% of the variance in the data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087301	In addition to neovascularization, vasculogenic mimicry (VM) is another mechanism recruited by high-grade tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "neovascularization", ",",...
PMC9429973	IGLV3-21 CLL accounts for approximately 20% of all CLL and is associated with an adverse prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IGLV3", "-", "21", "CLL", "...
PMC9874064	In this way, the anti-tumor activity of NP-Pt-USP1i was studied by a live and dead staining assay of the 3D tumor spheriod (Fig. 3G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794568	In particular, aberrant activation of mitochondrial biogenesis has been closely associated with the development of a variety of tumors, including melanoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...

PMC10847511

Mutational signature 3 were significantly higher in samples with HR-related gene alterations the those without (Mann-Whitney test, P = 0.037).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutatio...

PMC10421378

Caco-2 cell cultures with TEER values ≥ 600 Ω × cm were used in the bacteria adhesion experiments.

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PMC11682224

Data were presented as mean ± standard deviation and analyzed using t-tests for two-group comparisons and one-way ANOVA for multiple-group comparisons.

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PMC8806312

In summary, a 4-gene-based risk model may serve as a marker for predicting prognosis and correlates with immune infiltration in OS.

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PMC3203927

The cell seeding density was 50,000 cells/cm for both 2D and 3D cultures.

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PMC11286266

Biotinylation was conducted in vivo, where cells were co-transfected with a BirA-encoding plasmid (biotin ligase, UK2969) in a 1:0.06 ratio.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10604092

In fact, patients with cancer cachexia have increased resting energy expenditure, increased protein degradation and lipolysis, and decreased protein synthesis compared with healthy individuals .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11759751

The flow diagram of group therapy of B-NHL tail vein transplanted tumor mice constructed by Raji-Luc cells (A).

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PMC11297139

At post 4 days of spheroid formation, the volume of spheroid formed by LLPS-positive cells was larger than that of spheroid formed by negative cells. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11297139

We targeted cREs of previously reported EWS/FLI1 induced genes where chromatin accessibility is regulated by ARID1A LLPS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "targeted", "cREs", "of", "previously", ...

PMC6642070

The underlying mechanism of SAMS remains elusive, although several hypotheses have been proposed and extensively reviewed.

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PMC11739504

Scale bar: 2 μm (e) Graphs showed fluorescence intensity of IFT25 and IFT52 under serum starvation 6 h, 24 h in stable Kat2b KO NIH3Te and control NIH3T3. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11742290

Several LGR5 inhibitors have been identified in the literature, including 4-AAQB which negatively regulated the stem cell maintenance via the LGR5/WNT/β-catenin signaling pathway.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9583612

This top-down measurement needs to be scaled by the typical frequency and duration of events on the site to make a direct comparison to the annualized inventory.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9672323

These anti-cancer effects of NSAIDs are probably due to their anti-inflammatory actions, the ability to induce apoptosis in tumor cells, impair angiogenesis, and enhance T cell-dependent cellular immune responses, probably by suppressing PGE2 synthesis.

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PMC11730311

This highlights that the relationship between the length of the fatty acid and potency is complex and highly dependent on the specific lipidated peptide.

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PMC9429973

The development of mild or moderate cGVHD was associated with a better overall survival.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "development", "of", "mild", "or", "moderate", "cGVHD", "w...

PMC7192625

The tendencies observed for cross-ChAs for H3K9me3 are already present in the randomized networks, suggesting that 3D interactions might not have a strong effect on cross-ChAs estimations, apart from the cross-occurrence with H3K27me3, a mark heavily involved in 3D interactions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The most often mutations are 4bp insertions in exon 12, affecting 2 functionally important tryptophan residues (W288 and W290) in the C-terminal region of nucleophosmin and causing a frameshift.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8998437

While only trace amounts of the CCR3 and CCR5 transcripts were found, and low levels of CCR2 mRNA expression were detected in type III BL cell lines and LCLs, CCR1 mRNA expression was high in all three LCLs and in all two type III BL cell lines.

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PMC10999934

The cells were placed in a 6-well plate and grown until they reached 50% confluenc.

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PMC11461025

Lane 1: control cells (DMSO), Lane 2: 25 μM of isoginkgetin, Lane 3: 50 μM of isoginkgetin, Lane 4: 75 μM of isoginkgetin, Lane 5: 100 μM of isoginkgetin, Lane 6: 1 μM of staurosporine. (

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PMC9429973

of carfilzomib for > 1 year, leading to the outgrowth of clones with acquired carfilzomib resistance.

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PMC11740207

These cells exhibited symmetric division (SD) capabilities, the ability to initiate and drive disease progression, and cytological and morphological similarities to LSCs (Lapidot et al., 1994; Bonnet and Dick, 1997; Guan et al., 2003).

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PMC11247842

Enrichment analysis one of the methods to provide additional biological meaning to GWAS results, with statistical support.

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PMC8009078

A report suggests that M. alba juice and its fractions may inhibit internalization and replication of murine norovirus-1 (MNV-1), whereas it may influence adherence or internalization of feline calicivirus-F9 (FCV-F9) virions .

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PMC11401358

SF, GCTS, HA, COL, GEL, SA, HPMC, GUM and GSH (1 mg/mL) were incubated with 100 mM H2O2 at 37 °C for 1 h, respectively.

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PMC2777936

Additionally, while WNT5A mRNA levels were higher than that of other Wnt ligands, as assessed by real-time RT-PCR assays, it is not known if this relates to appreciably higher levels of Wnt protein or activity.

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PMC11732635

All cell processing steps are operated and double-checked by skilled technicians in good manufacturing practice (GMP).

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PMC11122631

The H NMR spectrum (Table 1) of 1 revealed resonant signals corresponding to a terminal methyl group [δH 0.88 (H-20)], two acetyl methyl groups (δH 2.09 and 2.04), a methoxy group (δH 3.70), an oxymethine [δH 5.75 (H-4)], and seven olefinic methines [δH 5.84 (H-5), 6.35 (H-6), 7.39 (H-7), 6.55 (H-10), 7.48 (H-11), 6.77...

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PMC11733919

Increased levels of lysosomes were also observed upon MNP@CD26 and MNP@CD26@17D treatment using the analysis of fluorescence signals of lysosomal marker Lamp1 fused to green fluorescence protein (GFP) (Figure 3e).

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PMC11576293

See Supplementary Material A1 for more details.

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PMC11782508

Each 20 µL PCR reaction mixture contained: 10 µL of Master-mix, 1 µM each of the forward and reverse primers (azuF and azuR), 1 µL of template DNA (50–100 ng/µL), and nuclease-free water to reach the final volume.

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PMC11473750

We have defined increased MYCN protein stability as a necessary feature during MYCN-related tumorigenesis.

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PMC11528603

Therefore, our finding suggested that SA-EA might, beside apoptotic death, hinder HL60 cells proliferation via p21 signaling pathway as well as decrease PCNA-dependent DNA replication.

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PMC9429973

Median OS was 130 days for R/R patients and 269 days for treatment-naïve patients; median DFS was 199 days for treatment-naïve patients and 145 days for R/R cohort.

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PMC3164356

Thus, this genome sequence of the ancestral K1 cell line should not be considered as completely representative of all CHO cell lines.

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PMC11705484

Quantitative ultra‐performance liquid chromatography/mass spectrometry analysis confirmed these results (Figure 1G–J).

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PMC11224020

In DCs confined at a height of 3 μm, most actin was found in a cloud located on the top of nuclei (Fig. 3b).Fig.

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PMC7812570

In contrast, the cotransduction of GPI-m36.4 had no obvious effect on the expression of the P24 antigen, which was released into the cell culture medium at high levels when a control vector was cotransfected.

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PMC11126803

Hence, a comprehensive understanding of the mechanisms of RCC progression and angiogenesis is required to develop better therapeutic strategies.

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PMC11772585

G MMP was measured by flow cytometry (n = 3).

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PMC9429973

Lower GAS5 expression on diagnosis was related to an adverse prognosis, since higher levels of lactate dehydrogenase was detected in the GAS5low group compared to the GAS5high group (p < 0.01).

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PMC9429973

Therefore the aim of this study was to characterise the neoantigen burden (NAB) in DLBCL by COO subtype as well as elucidate the relationship between NAB, tumour microenvironment and disease pathogenesis.

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PMC11400680

As a training result, our prompt detector achieved mAP50 up to 0.855 showing 0.965 for the cell class and 0.745 for the nucleus class.

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PMC11782508

(d) ¹H NMR spectrum obtained at 500 MHz.

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PMC11544122

These data suggest that in addition to the β-arrestin and SNX9/18 modes for GPCR endocytosis, additional modes exist.

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PMC11765678

Membranes were incubated with a primary antibody overnight at 4 °C and diluted in EveryBlot Blocking Reagent: rabbit anti-GADPH (Novus, NBP2-20859; 1:1000), mouse anti-Pgp (Santa Cruz Biotechnology, TX, USA; 1:200), and rabbit anti-BCRP (Abcam, 1:1000).

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PMC7987994

In this case, the degradation is expected and required and some conditions for in vitro testing stated in the standard might be too stringent leading to nonrelevant results.

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PMC11543853

Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.

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PMC11342785

However, this approach did not produce the large-scale MT bundles observed in vitro and in the oligodendrocyte cytoskeleton.

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PMC5839394

Furthermore, the production of other metal nanoparticles embedded in this EPS has already been reported [21–25].

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PMC5025404

Transfection was performed in a similar manner as described above.

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PMC11693599

CD109 is known to promote stemness properties, such as sphere-forming ability, drug resistance, tumor initiation, metastasis, and epithelial-to-mesenchymal transition, in various cancer cells (17-20).

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PMC11547972

Controls remained untreated.

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PMC5925824

Anti-CD20 antibody rituximab (wild type IgG1) was tested as a positive control in the same assay against the CD20-positive WIL2-S cell line.

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PMC10706275

Over 60 successive passages, monoclonal cell lines were produced that consistently expressed all relevant external proteins without discernible variation in expression levels.

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PMC11469524

An increase in MEK and ERK phosphorylation as early as 2 min after α-IgM-mediated BCR stimulation is observed in the presence of the p38 inhibitor SB203580.

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PMC11594588

The MitoXpress Xtra probe provides a powerful tool for the detailed investigation of this most critical of biological parameters like the analysis the concentration of molecular oxygen within the cell monolayer; a real-time assessment of transient changes in cell respiration, concentration, and consumption; hypoxia and...

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PMC11657744

Our results suggest that CEP89 and FBF1 are critical for timely ciliary disassembly, which is necessary for proper cell cycle progression.

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PMC7823217

Bioprinted breast, brain, skin, colorectal, pancreatic, and other cancer models were highly successful in mimicking tumour anatomy, physiology, and molecular biology.

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PMC11506670

Further, mutations in NRAS are linked to poorer survival and outcomes compared to both KRAS-mutant and wild-type mCRC .

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PMC11791264

However, others have noted an oncogenic role for SETD7 in prostate cancer (28), hepatocellular carcinoma (29), and intestinal tumorigenesis (30).

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PMC5833712

d Representative Western blot and e densitometric analysis of PARP1 cleavage in A2780cis cells transfected with non-specific or SIRT1 and KDM6B-specific siRNAs after 24 h treatment with 40 μM of cisplatin alone or in combination with 10 nM of KB9520.

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PMC10926885

Dynein cell light intermediate chain 1 (DYNC1LI1) influences the sensitivity of colorectal cancer to radiation and chemotherapy and is linked to pancreatic ductal adenocarcinoma, hepatocellular carcinoma and prostate cancer.

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PMC7192625

H3K36me3 was the mark with the least increased ChAs in the PP subnetwork compared to distance preserving randomization, showing a moderate impact of 3D interactions in the preferential contacts established between regions with the mark.

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PMC11670954

Collectively, these data demonstrate that Y-27632 synergizes with BA to alleviate the decreased in the expression and abnormal localization of ZO-1 and Occludin, indicating that the RhoA/ROCK2/MLCK signaling pathway may be involved in the protective effects of BA on tight junction proteins. (

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PMC6803987

What is worth reminding is that in the high-dose group (80 mg/mL) these were more significant improvement compared with 3TC (20 mg/mL), and it also had a more significant liver-protecting effect.

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PMC8557138

Subsequent, binding of VEGF-A to its cognate receptor VEGFR2 on the endothelial cells (EC) of the neighboring blood vessels induces the expression of genes involved in EC proliferation and migration (Stacker and Achen 2013).

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PMC10944868

On the other hand, blood-Brain Barrier (BBB) property is crucial for the effectiveness of drugs in treating central nervous system disorders.

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PMC8469018

At any tested concentrations of drug, we did not observe the inhibition of cell cycle in the G1 phase, which is typical for DHODH inhibition .

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PMC9351137

Indeed, chromosome segregation defects during mitosis produce aneuploidy which lead to chromosomal instability, a principal contributor to genetic heterogeneity in cancer and an important determinant of clinical prognosis and therapeutic resistance.

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PMC11469524

Data was generated by pre-treating BL-2 cells with inhibitors targeting key effectors downstream of BCR for 3h with subsequent BCR stimulation using α-IgM for 30 min (upper panel) or no stimulation as consistency check (lower panel).

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PMC11190062

Here, we show that inhibiting the lysosomal degradation pathway by HCQ treatment had a potentiating effect on carfilzomib-induced cytotoxicity and that HCQ treatment reduced the protective effect of LPS and CpG stimulation on PI-induced cytotoxicity.

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PMC10852540

Source: elaborated by the authors.

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PMC11772585

Furthermore, we observed that ATF4 overexpression increased the proliferation of cSCC cells in vivo, as evidenced by elevated levels of PCNA protein (Fig. 7E, F) and mRNA (Fig. 7G).

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PMC11635519

The lentiviral vector pLJM1 with the human CMV promoter and a green fluorescent protein (GFP) as an N-terminal tag with a puromycin selection marker was used for selecting the infected cells.

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PMC11194678

RBD45 was insufficient to initiate LLPS; instead, a condensed liquid phase robustly formed for STAU1 fragments containing RBD23 (e.g., WT, RBD2345, RBD23).

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PMC11543885

Decant and wash twice with freshly prepared quencher buffer, each wash lasting 1 min.14.Immediately decant the final wash and fix the cells with 4% (wt/vol) paraformaldehyde (PFA), followed by permeabilization and blocking as described above.15.After blocking, incubate the cells with 100 μL diluted anti-NLRP3 or anti-f...

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PMC9429973

U. Platzbecker, E. Angelucci, P. Montesinos, R. M. Lemoli, A. Spyridonidis, J. Casariego, T. I. Mughal, M. Mohty Medical Clinic and Policlinic of Hematology, Cell Therapy and Hemostaseology, University Hospital Leipzig, Leipzig, Germany; Hematology and Cellular Therapy Unit, IRCCS Ospedale Policlinico San Martino, Geno...

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PMC6461034

A “skew” parameter is calculated to indicate the relative contribution of kinase‐centric versus substrate‐centric evidence to the INKA score (equation (4)).

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PMC9429973

The thrombotic complications are more frequent in severe form of COVID-19 patients who associated lymphopenia, group 1-28.22% vs group 2- 13.12%, Chi-squared 10.03, p=0.001, thrombosis was an important covariate in Cox proportional hazard regression, Wald 6.72, p=0.01 .

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PMC9516447

In agreement with previous studies that HA15 and YUM70 at the concentrations used did not affect the viability of normal cells , both HA15 and YUM70 treatment showed minimal toxicity in the normal human bronchial epithelial cell line BEAS-2B (Supp.

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PMC9019892

Therefore, we next investigated whether FGFR‐mediated reactivation of the MAPK pathway can attenuate the antiproliferative effect of nintedanib in GISTs (Fig. 4A).

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PMC8777939

Tissue samples isolated from an orthotopic xenograft model were used for histological analysis.

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PMC7553912

The kidney was minced into fine pieces and digested with collagenase type II (Sigma) dissolved in Dulbecco's modified Eagle's medium (DMEM; Invitrogen, Carlsbad, CA) supplemented with 2% fetal calf serum (FCS) using a gentleMACS Dissociator (Miltenyi Biotec, Bergisch Gladbach, Germany).

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PMC5600151

Their architecture, which can be controlled by different synthesis processes, allows the control of characteristics such as shape, size, charge, and solubility.

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PMC6803987

IV (8.0 g) was further separated by RP-18 column chromatography, and gradient elution was carried out (0% ~ 100%, MeOH-H2O) to obtain a total of 29 fractions of Fr.

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PMC9065483

Inhibition of the EGFR pathway abrogates vanadate-enhanced viral infectivity (A) Human 786-0 renal carcinoma cells were pre-treated with or without vanadate (150 μM) and varying concentrations of gefitinib (0–50 μM) as indicated for 4 h. Cells were then treated with 10 ng/mL EGF for 10 min and lysates were probed by we...

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PMC9429973

Two patients without humoral and T cell responses contracted COVID-19, emphasizing the need for vaccination against SARS-CoV2 in order to protect this highly vulnerable population.

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PMC11741906

For example, miRNA's expression profiling in the SGC -7901 line resistant to 5-fluorouracil revealed that hsa-miR-133b upregulation occurring upon resistance acquisition.

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PMC8540692

Thus, the data suggest that ROS generation may be responsible for the observed increase in the apoptotic cell number in CCM and NaBu-treated GBM cells.

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PMC11591038

PS1/2 γ-secretase-mediated cleavage of the APP generates AICD, which functions as a transcriptional activator to induce Hif1a gene expression; on the other hand, PS1/2 itself, in a γ-secretase-independent manner, increases PHD2 activity to promote HIF-1α degradation in vitro .

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PMC9429973

Methods: RNA-seq was applied to RNA samples from FFPE blocks of DLBCL patients, 4 of whom were previously classified as GCB and the remaining 4 as ABC, based on NanoString-LST.

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PMC10728535

Regarding the fact that several molecular mechanisms such as decreased drug uptake and increased drug efflux are involved in cancer drug resistance, we focused on membrane ion channels, pumps, and transmembrane proteins as well as their regulators in obtained DEGs.

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PMC11306019

For this study, we primarily used the first three principal components (PC1, PC2, and PC3), which account for 71% of the variance in the data.

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PMC11087301

In addition to neovascularization, vasculogenic mimicry (VM) is another mechanism recruited by high-grade tumors.

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PMC9429973

IGLV3-21 CLL accounts for approximately 20% of all CLL and is associated with an adverse prognosis.

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PMC9874064

In this way, the anti-tumor activity of NP-Pt-USP1i was studied by a live and dead staining assay of the 3D tumor spheriod (Fig. 3G).

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PMC11794568

In particular, aberrant activation of mitochondrial biogenesis has been closely associated with the development of a variety of tumors, including melanoma.

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