OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9884169	Ferroptosis and autophagy have an important role in the occurrence and development of cancer, and lactate in cells and microenvironment is one of the influencing factors of ferroptosis and autophagy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8806312	Expression patterns of 29 immune-related genes (IRGs) in nonmetastatic and metastatic osteosarcoma samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "patterns", "of", "29", "immune-related", "genes", ...
PMC11473750	d Immunoblot analysis of RNF121 expression in human MYCN non-amplified neuroblastoma cell line, SH-SY5Y, following transfection with either RNF121 wild type or RNF121.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9712534	TOP2 poisons, such as etoposide, stabilize the covalent TOP2–DNA complex, which is readily converted into a DNA double-strand break in cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10747160	While the development of several COVID-19 vaccines has alleviated the severity of the pandemic, COVID-19 cases persist, with about 10,000 COVID-19 hospitalizations occurring weekly nationwide in the United States throughout the months of May to July of 2023 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	Data normalized against the DMSO control and expressed as the mean ± SEM of two independent assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "normalized", "against", "the", "DMSO", ...
PMC11055510	The cells were incubated in a 37 °C, 5% CO2 incubator for 60 minutes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "incubated", "in", "...
PMC9693627	GFP-positive cells were selected and genotyped for the desired deletions by PCR and Sanger sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GFP-positive", "cells", "were", "selected", "and", "genotyped", ...
PMC6222726	Fruits are 1 to 1.3 cm long, 0.8 to 1.1 cm wide with a black pit, and partially covered by a red, orange, or pale pseudoaril.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8759873	The MTT test showed that the cell growth of the ultrasound microbubble group was significantly inhibited, the use of deep learning models is better for the research of this article , the flow cytometry test showed that the apoptosis rate of the ultrasound microbubble group increased , and the experiment was repeated ma...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11518702	In early studies, transgenic mice expressing HGAL from a Sca1-promoter demonstrated effects on polyclonal B-cell lymphoid hyperplasia, hypergammaglobinuria, and amyloid-A amyloidosis (13).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8414691	D left panel: normal telophase (mock); right panel: long intercellular bridge (RNAi).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "left", "panel", ":", "...
PMC9856122	The possible mechanism by which isoquinoline-related alkaloids could show antiviral activity is illustrated in Figure 2 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "possible", "mechanism", "by", "which", "isoquin...
PMC4695073	Platinum-based concurrent chemoradiotherapy is one of the standard treatment approaches for locally advanced NPC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Platinum-based", "concurrent", "chemoradiotherapy", "is", "one", "of", ...
PMC6222635	Therefore, δ3.28 can be attributed to the C2 hydrogen of β-(1→4)-linked glucose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "δ3.28", "can", "be", "attributed", "to", "the", "C2...
PMC8140214	Measurement of Cu, Zn-SOD activity We measured the activity of Cu, Zn-SOD in HepG-2 cell lysate based on the procedure that was described by Misra and Fridovich (Misra and Fridovich, 1972 ▶).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	Cell type annotation is shown in Supplementary Fig. 1d.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "type", "annotation", "is", "shown", "in", "Supplementary", "Fig.", "1d", "." ] } ]
PMC10079526	One-way ANOVA, Tukey’s multiple comparisons with Graphpad prism Version 9.3.1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One-way", "ANOVA", ",", "Tukey", "’s", "multiple", "comparisons", "with", "Graph...
PMC11477621	The crude product was purified by silica gel chromatography to give the brown solid (28 mg, 62%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "crude", "p...
PMC3122064	Importantly, we have observed that the Fas/FasL system also has an important role in Nutlin-3-induced apoptosis of wild-type p53-expressing AML and Hodgkin cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6627640	Cisplatin adduct formation was similar in the parental and resistant cells after acute 3-hour exposure to cisplatin, suggesting that the resistance was not due to decreased cisplatin uptake (Figure 1F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The average article processing charges among was $2,485 USD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "average", "article", "processing", "charges", "among", "was", "$", "2,485", "USD", ...
PMC11686380	At nine years of age, her full-scale intelligence quotient was 48 according to the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11803149	Cells were cultured in the presence of IL-7 and IL-15 for 6 days. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "cultured", "in", "the", "presence", "of", "IL-7...
PMC6835428	Within relapsing patients, about 50% are still responsive to PTX, even though persistent side effects from previous treatment may become problematic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11535726	This study has the following objectives: 1) to describe novel species associated with decaying wood through comprehensive morphological examinations and phylogenetic analyses of ITS, LSU and SSU rDNA sequence data; 2) to provide a checklist that includes host information, habitat preferences, availability of molecular ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11506670	To further assess the effect of the NRAS mutants, web-based prediction tools were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "assess", "the", "effect", "of", "the", ...
PMC8839885	The chemical structure of RJY13 is also shown. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "chemical", "structure", "of", "RJY13", "is", "also", "shown", ".", "(" ] } ]
PMC6684588	Physiological cross-sectional area (pCSA) of ACE-083-injected and vehicle-injected TA muscles in wild-type and mdx mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Physiological", "cross-sectional", "area", "(", "...
PMC11783017	TEM images of Lipo-IL11, MnO2, and Cis/Mn@Lipo-IL11. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TEM", "images", "of", "Lipo-IL11", ",", "MnO2", ",", "and", "Cis/Mn@Lipo-IL11", ".", "(" ...
PMC9429973	Aims: To report data from the ongoing long-term extension (LTE) period (≤Wk 72; data cutoff 27Mar2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", ...
PMC11348300	With this goal, ALA was injected i.v.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "this", "goal", ",", "ALA", "was", "injected", "i.v", "." ] } ]
PMC11519567	Binding to the H2AK119ub was shown by immunoblotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Binding", "to", "the", "H2AK119ub", "was", "shown", "by", "immunoblotting", "." ] } ]
PMC10222971	A gating strategy was used to distinguish the fluorescently labelled cell population from unstained populations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "gating", "strategy", "was", "used", "to", "distinguish...
PMC5839394	This fluorescence method is specific, sensitive and reliable enough to characterise and distinguish even similar synthetic organic dyes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "fluorescence", "method", ...
PMC9268620	The plasma membranes and cytoskeletons also showed marked morphological changes upon treatment with damnacanthal and nordamnacanthal, indicating apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plasma", "membranes", "and...
PMC11699465	Data are represented as mean ± SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "represented", "as", "mean", "±", "SEM", "." ] } ]
PMC9429973	B. E. Wahlin, J. Brody, T. Phillips, R. Costello, P. Lugtenburg, R. Cordoba, L. Wang, J. Wu, B. Elliott, A. Abbas, J. Jørgensen Karolinska Institutet, Stockholm, Sweden; Icahn School of Medicine at Mount Sinai, New York; University of Michigan Comprehensive Cancer Center, Ann Arbor, United States of America; Assistance...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11454387	The resulting interactome revealed a potential hit cluster of protein disulfide isomerase (PDI) family members, different ER-resident chaperones and luminal calcium binding proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11021472	EZview protein G beads (Merck Life Science NV, Darmstadt, Germany) were pre-blocked using 5% BSA and 2 µg/µL of salmon sperm sonicated ssDNA (Merck Life Science NV), before they were incubated with 10 µg/mL anti-AGO2 antibody (clone 2E12-1C9, Abnova).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11686380	One of the limitations of our study is that we were unable to fully assess the impact of the variant due to its instability, which hindered stable expression in both in vitro and in vivo models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This system aims at decreasing the interobserver variability associated with bone marrow DCC and improving the efficiency due to the increased speed of cell quantification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11706297	Both media included 10% fetal bovine serum (FBS) (Sigma Aldrich, MO, USA) and 89 μg/mL streptomycin (Meiji Seika Pharma, Tokyo, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: The primary objectives of this study are to characterize the pharmacokinetic (PK) profile of asciminib in pediatric pts and identify a pediatric formulation dose leading to an asciminib exposure comparable to the adult dose, 40 mg BID.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11509224	Furthermore, there are five diterpenoids that originate from sponges that have not yet been identified at the genus level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "there", ...
PMC11088135	There is growing evidences that dysregulation of lncRNA is closely associated with the development of glioma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "growing", "evidences", "that", "dysregu...
PMC9429973	Can ctDNA identify molecular groups with phenotype- and outcome-associated signatures?	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Can", "ctDNA", "identify", "molecular", "groups", "with", "phenotype-", "and", "outcome-associated", ...
PMC9429973	Clonogenic capacity was tested by clonogenic assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clonogenic", "capacity", "was", "tested", "by", "clonogenic", "assays", "." ] } ]
PMC11228511	In the setting of progerin expression in Lmna mice, where progerin protein accumulates with age while lamin B1 levels fall, the progerin:lamin B1 ratio in the aorta rises to very high levels; the progerin:lamin B1 ratio in the aorta is ~25 to 30 (relative to the kidney set at 1), whereas it is only ~2.5 in left ventric...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9046263	In gliomas, HERV-K (HML-2) expression has been detected in specific tumor samples and cell lines through reverse transcriptase-qPCR; however, the extent and depth of HERV expression in gliomas has not been established to date.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10823017	Effect of a-PKC inhibitors, BYL719 and combination therapy on a-PKCs in 786-0 and Caki-1 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Effect", ...
PMC11695623	Down-regulation of DCUN1D5 can significantly affect the biological behavior of lung adenocarcinoma cells, which may be related to glycolysis and immune cell infiltration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10218459	In the case of osseous malignancies, the bony environment plays an unfavorable role, acting as a barrier hindering the diffusion of therapeutic agents .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11545868	Yao, Z., X. Xu, and Y. Huang discussed how the daidzin treatment of cervical cancer HeLa cells at 20 μM increased mitochondrial membrane permeability and induced apoptosis due to an increase in caspase 8 and 9 (Table 1) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC11469524	This indicates that a common model of BL and DLBCL would perform poorly and local adjustments are still required but that a common conserved core network of BCR downstream signaling exists.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9046263	The potential role of HML-6 as a driver of GBM oncogenesis may center on its unique gene product, ERVK3-1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "poten...
PMC11746942	Additionally, activated STAT3 binds to the S1PR3 promoter and upregulates its expression, creating a positive feedback loop to perpetuate the hyperproliferation and inflammatory state in psoriasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607638	Male Sprague–Dawley (RRID:RGD‐70508) rats (250–450 g in body weight) were killed by asphyxia in 100% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC6803987	3TC was obtained from Yuanye Bio-Technology & Co Ltd. (Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3TC", "was", "obtained", "from", "Yuanye", "Bio-Technology", "&", ...
PMC9429973	A prior history of MDS or MDS/MPN was documented in 20% (8/41) of SF3B1 patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "prior", "history", "of", "MDS", ...
PMC10222971	In Spain, this disease constitutes the second leading cause of death (25.2%) after those caused by diseases of the circulatory system (26.4%) in 2021 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731161	The detailed information of patients is listed in supplementary Table S1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "detailed", "information", "of", "patients", "is", "listed", "in", "supplementary", ...
PMC11753949	Hippocampal neurons were transfected on DIV11–13 using the CalPhos Mammalian Transfection kit (Takara) according to manufacturer’s instructions, and imaged at DIV16–28 either live or after fixation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9370419	The integrated genes included the controllable TCE (tetracycline response element and minimal CMV-promoter enhanced) promoter, which enhanced the expression of HiBiT-HBx in a tetracycline-inducible manner, whereas the rTetR sequence expressed the rtTA protein and the hygromycin gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698	This work was financially supported by 10.13039/501100018557Nantong Science and Technology Project (MS22021001), 10.13039/100016086Suzhou Special project of diagnosis and treatment technology for key clinical diseases (LCZX202204).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5941560	Overlaps between the duplications, long insertions, and long deletions from Jurkat and DGV/1000Genomes were counted if there was greater than 25% reciprocal overlap.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11047729	In this study, we will discuss the natural inhibitors of telomerase, which are included in Table 1 and Table 2, and show their potential as novel mono- and multitherapy ingredients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11345828	The resultant diastereomers are separable by high-performance liquid chromatography (HPLC), thermally stable (no interconversion observed at 120 °C for 72 h), and can be used to access either atropisomer of the final compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The mutational signature was performed with SignatureAnalyzer software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mutational", "signature", "was", "performed", "with", "SignatureAnalyzer", "software", "." ] } ]
PMC11711063	In contrast, colony formation was moderately inhibited by Bex or Carv, and more pronounced by the combination of Bex + Carv in all cell lines (Figure 5A–C, second graphs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11773391	The authors have nothing to report.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "authors", "have", "nothing", "to", "report", "." ] } ]
PMC8494202	Subsequently, the membrane was incubated with primary specific antibodies for cell cycle-related proteins, including CDK4 (1 : 1000, Proteintech, Chicago, IL, USA), CCNB1 (1 : 1000, Proteintech), CCND1 (1 : 1000, Proteintech), CCNE1 (1 : 1000, Proteintech), and GAPDH (1 : 1000, Proteintech), followed by three washes wi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The majority of these patients is unfit for aggressive treatment protocols and the lack of randomized trials in this category makes it difficult to choose the best regimen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Efflux activity was examined using combination of mitoxantrone (ABCB1 substrate) and midostaurin (ABCB1/FLT3 inhibitor).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Efflux", "activity", "was", "examined", ...
PMC9429973	Enteral nutritional support was associated with a reduced frequency of nasogastric tube insertion when adjusted for age, sex, and baseline BMI: OR=0.16, 95%CI 0.03-0.83, p=0.029.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10723784	The cytotoxic effect of 30 μM of CBD alone and in combination with tocopherol (1 nM to 100 μM) on the A2780 and A2780/CP70 cell line after 24 and 48 h contact time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLin...
PMC8557138	In contrast, dopamine has been shown to inhibit the expression of VEGF and MMP9 (Chakroborty et al. 2009).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ...
PMC11519077	IL-1β-induced Caco-2 cells 3.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "IL-1β-induced", "Caco-2", "cells", "3", "." ] } ]
PMC9429973	Health-state utility weights and disutilities of bleeds were obtained from published literature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Health-state", "utility", "weights", "and", "disutilities", "of", "bleeds", "were", ...
PMC10654497	In addition, we calculated the best risk score cutoff value using the R software package “maxstat” and adjusted the minimum and maximum numbers of grouped samples to be larger than 25% and less than 75%, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6450504	Following the monolayer studies, penetration of PEIPOS in the spheroid model was evaluated (Figure 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "the", "monolayer", "studies", ...
PMC9429973	Dynamic BH3 profiling using synthetic BH3-peptides was performed to determine the dependency of ALL cells on BCL-2 family proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dynamic", "BH3", "profiling", "us...
PMC9412887	Selenium can promote the generation of CD8+ T cells and increase the secretion of perforin and granulation enzyme .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Selenium", "can", "promote", "the...
PMC11774747	Recombinant human interleukine-2 (IL-2) is the most common cytokine promoting T cell survival and proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recombinant", "human", "interleukine-2", "(", "IL...
PMC11126803	Not all of these noncoding RNAs can regulate ERβ expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Not", "all", "of", "these", "noncoding", "RNAs", "can", "regulate", "ERβ", "expression", "...
PMC11753435	We also simultaneously cotransfected 10 individual peptides designed with PepPrCLIP (table S3), which were fused to CHIPΔTPR-IRES-TagBFP, and monitored the expression of the SS18-SSX1 fusion via the linked mCherry reporter (see schematic in Fig. 5B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10196713	After fixation, cells were incubated with antibodies against Fdx1 (1:100; cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "fixation", ",", "cells", "were", "incubated", "with", "...
PMC10142392	The micelles with PVP chains with seven arms on the outside showed the lowest amount of protein adsorption and the best stability in media, demonstrating the effect of the number of arms on encapsulation parameters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11483468	Then, an Acx primer [5'-(CCCTTA) 3CCCTAA-3'] was added.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "an", "Acx", "primer", "[", "5'-(CCCTTA", ")", "3CCCTAA-3...
PMC11391695	Additionally, western blot analyses indicated a 50% reduction in the expression of the ACYP2 protein in HCC tissues relative to the neighboring normal tissues (Fig. 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721064	Total RNA was extracted using TRIzol Reagent (Thermo Fisher Scientific) and subsequently converted to cDNA using a reverse transcription kit (GeneCopoeia, Rockville, MD, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	Notably, the modest but significant changes in liver regeneration caused by the manipulation of Mecp2 in the first 2 d after PHx disappeared 5 d post-PHx (Figure 2—figure supplement 1H–J), indicating the involvement of Mecp2 in not only quiescence exit but also in later stages of cell proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5673060	Data were further analysed using Microsoft Office Excel 2010 and Perseus (version 1.5.5.3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "further", "analysed", "using", "Microsoft", ...
PMC10798140	As a result, this chemical is a good option for anticancer therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "result", ",", "this", "chemical", "is", "a", "good", ...
PMC5173112	Complementarily, forced expression of USP21 leads to increase of tumorigenic properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Complementarily", ",", "forced", "expression", "of", "USP21", "leads", "to", "in...
PMC11310713	Sections were then treated with peroxidase-blocking solution (DAKO, Carpinteria, CA, USA) and incubated with primary antibodies at 4°C overnight: anti-p53 (ab131442, Abcam, Cambridge, UK), anti-PTEN (ab267787, Abcam), and anti-KI67 (NB500-170, Novus Biologicals, Littleton, CO, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A total of 342 SAA patients were enrolled, with 183 patients receiving HID SCT and 159 receiving ISD SCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "34...
PMC9429973	Medical/surgical history (odds ratio[OR], 5.16; 95% CI, 1.91–13.92; P=0.001), splenectomy (OR, 2.86; 95% CI, 1.16–7.02; P=0.022), and >24 transfusion events in 48 weeks prior to enrollment (OR, 2.78; 95% CI, 1.15–6.74; P=0.023) were associated with increased odds for developing treatment-related complications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3931643	Nevertheless, the induced binding of 4EBP2 to eIF4E seemed to be ineffective at displacing eIF4G and was therefore unable to compensate for loss of 4EBP1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5963610	These facts combined to the low toxicity of anti-EGFR mAb, Nimotuzumab and the NGcGM3/VSSP vaccine , justify further exploration in clinical trials of the combination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9884169

Ferroptosis and autophagy have an important role in the occurrence and development of cancer, and lactate in cells and microenvironment is one of the influencing factors of ferroptosis and autophagy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8806312

Expression patterns of 29 immune-related genes (IRGs) in nonmetastatic and metastatic osteosarcoma samples.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "patterns", "of", "29", "immune-related", "genes", ...

PMC11473750

d Immunoblot analysis of RNF121 expression in human MYCN non-amplified neuroblastoma cell line, SH-SY5Y, following transfection with either RNF121 wild type or RNF121.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9712534

TOP2 poisons, such as etoposide, stabilize the covalent TOP2–DNA complex, which is readily converted into a DNA double-strand break in cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10747160

While the development of several COVID-19 vaccines has alleviated the severity of the pandemic, COVID-19 cases persist, with about 10,000 COVID-19 hospitalizations occurring weekly nationwide in the United States throughout the months of May to July of 2023 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10988555

Data normalized against the DMSO control and expressed as the mean ± SEM of two independent assays.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "normalized", "against", "the", "DMSO", ...

PMC11055510

The cells were incubated in a 37 °C, 5% CO2 incubator for 60 minutes.

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PMC9693627

GFP-positive cells were selected and genotyped for the desired deletions by PCR and Sanger sequencing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GFP-positive", "cells", "were", "selected", "and", "genotyped", ...

PMC6222726

Fruits are 1 to 1.3 cm long, 0.8 to 1.1 cm wide with a black pit, and partially covered by a red, orange, or pale pseudoaril.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8759873

The MTT test showed that the cell growth of the ultrasound microbubble group was significantly inhibited, the use of deep learning models is better for the research of this article , the flow cytometry test showed that the apoptosis rate of the ultrasound microbubble group increased , and the experiment was repeated ma...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11518702

In early studies, transgenic mice expressing HGAL from a Sca1-promoter demonstrated effects on polyclonal B-cell lymphoid hyperplasia, hypergammaglobinuria, and amyloid-A amyloidosis (13).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8414691

D left panel: normal telophase (mock); right panel: long intercellular bridge (RNAi).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "left", "panel", ":", "...

PMC9856122

The possible mechanism by which isoquinoline-related alkaloids could show antiviral activity is illustrated in Figure 2 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "possible", "mechanism", "by", "which", "isoquin...

PMC4695073

Platinum-based concurrent chemoradiotherapy is one of the standard treatment approaches for locally advanced NPC .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Platinum-based", "concurrent", "chemoradiotherapy", "is", "one", "of", ...

PMC6222635

Therefore, δ3.28 can be attributed to the C2 hydrogen of β-(1→4)-linked glucose.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "δ3.28", "can", "be", "attributed", "to", "the", "C2...

PMC8140214

Measurement of Cu, Zn-SOD activity We measured the activity of Cu, Zn-SOD in HepG-2 cell lysate based on the procedure that was described by Misra and Fridovich (Misra and Fridovich, 1972 ▶).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11787355

Cell type annotation is shown in Supplementary Fig. 1d.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "type", "annotation", "is", "shown", "in", "Supplementary", "Fig.", "1d", "." ] } ]

PMC10079526

One-way ANOVA, Tukey’s multiple comparisons with Graphpad prism Version 9.3.1.

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PMC11477621

The crude product was purified by silica gel chromatography to give the brown solid (28 mg, 62%).

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PMC3122064

Importantly, we have observed that the Fas/FasL system also has an important role in Nutlin-3-induced apoptosis of wild-type p53-expressing AML and Hodgkin cell lines.

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PMC6627640

Cisplatin adduct formation was similar in the parental and resistant cells after acute 3-hour exposure to cisplatin, suggesting that the resistance was not due to decreased cisplatin uptake (Figure 1F).

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PMC9429973

The average article processing charges among was $2,485 USD.

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PMC11686380

At nine years of age, her full-scale intelligence quotient was 48 according to the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV).

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PMC11803149

Cells were cultured in the presence of IL-7 and IL-15 for 6 days. (

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PMC6835428

Within relapsing patients, about 50% are still responsive to PTX, even though persistent side effects from previous treatment may become problematic.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11535726

This study has the following objectives: 1) to describe novel species associated with decaying wood through comprehensive morphological examinations and phylogenetic analyses of ITS, LSU and SSU rDNA sequence data; 2) to provide a checklist that includes host information, habitat preferences, availability of molecular ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11506670

To further assess the effect of the NRAS mutants, web-based prediction tools were used.

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PMC8839885

The chemical structure of RJY13 is also shown. (

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PMC6684588

Physiological cross-sectional area (pCSA) of ACE-083-injected and vehicle-injected TA muscles in wild-type and mdx mice.

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PMC11783017

TEM images of Lipo-IL11, MnO2, and Cis/Mn@Lipo-IL11. (

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PMC9429973

Aims: To report data from the ongoing long-term extension (LTE) period (≤Wk 72; data cutoff 27Mar2021).

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PMC11348300

With this goal, ALA was injected i.v.

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PMC11519567

Binding to the H2AK119ub was shown by immunoblotting.

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PMC10222971

A gating strategy was used to distinguish the fluorescently labelled cell population from unstained populations.

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PMC5839394

This fluorescence method is specific, sensitive and reliable enough to characterise and distinguish even similar synthetic organic dyes .

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PMC9268620

The plasma membranes and cytoskeletons also showed marked morphological changes upon treatment with damnacanthal and nordamnacanthal, indicating apoptosis.

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PMC11699465

Data are represented as mean ± SEM.

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PMC9429973

B. E. Wahlin, J. Brody, T. Phillips, R. Costello, P. Lugtenburg, R. Cordoba, L. Wang, J. Wu, B. Elliott, A. Abbas, J. Jørgensen Karolinska Institutet, Stockholm, Sweden; Icahn School of Medicine at Mount Sinai, New York; University of Michigan Comprehensive Cancer Center, Ann Arbor, United States of America; Assistance...

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PMC11454387

The resulting interactome revealed a potential hit cluster of protein disulfide isomerase (PDI) family members, different ER-resident chaperones and luminal calcium binding proteins.

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PMC11021472

EZview protein G beads (Merck Life Science NV, Darmstadt, Germany) were pre-blocked using 5% BSA and 2 µg/µL of salmon sperm sonicated ssDNA (Merck Life Science NV), before they were incubated with 10 µg/mL anti-AGO2 antibody (clone 2E12-1C9, Abnova).

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PMC11686380

One of the limitations of our study is that we were unable to fully assess the impact of the variant due to its instability, which hindered stable expression in both in vitro and in vivo models.

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PMC9429973

This system aims at decreasing the interobserver variability associated with bone marrow DCC and improving the efficiency due to the increased speed of cell quantification.

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PMC11706297

Both media included 10% fetal bovine serum (FBS) (Sigma Aldrich, MO, USA) and 89 μg/mL streptomycin (Meiji Seika Pharma, Tokyo, Japan).

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PMC9429973

Aims: The primary objectives of this study are to characterize the pharmacokinetic (PK) profile of asciminib in pediatric pts and identify a pediatric formulation dose leading to an asciminib exposure comparable to the adult dose, 40 mg BID.

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PMC11509224

Furthermore, there are five diterpenoids that originate from sponges that have not yet been identified at the genus level.

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PMC11088135

There is growing evidences that dysregulation of lncRNA is closely associated with the development of glioma .

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PMC9429973

Can ctDNA identify molecular groups with phenotype- and outcome-associated signatures?

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PMC9429973

Clonogenic capacity was tested by clonogenic assays.

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PMC11228511

In the setting of progerin expression in Lmna mice, where progerin protein accumulates with age while lamin B1 levels fall, the progerin:lamin B1 ratio in the aorta rises to very high levels; the progerin:lamin B1 ratio in the aorta is ~25 to 30 (relative to the kidney set at 1), whereas it is only ~2.5 in left ventric...

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PMC9046263

In gliomas, HERV-K (HML-2) expression has been detected in specific tumor samples and cell lines through reverse transcriptase-qPCR; however, the extent and depth of HERV expression in gliomas has not been established to date.

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PMC10823017

Effect of a-PKC inhibitors, BYL719 and combination therapy on a-PKCs in 786-0 and Caki-1 cells. (

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PMC11695623

Down-regulation of DCUN1D5 can significantly affect the biological behavior of lung adenocarcinoma cells, which may be related to glycolysis and immune cell infiltration.

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PMC10218459

In the case of osseous malignancies, the bony environment plays an unfavorable role, acting as a barrier hindering the diffusion of therapeutic agents .

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PMC11545868

Yao, Z., X. Xu, and Y. Huang discussed how the daidzin treatment of cervical cancer HeLa cells at 20 μM increased mitochondrial membrane permeability and induced apoptosis due to an increase in caspase 8 and 9 (Table 1) .

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PMC11469524

This indicates that a common model of BL and DLBCL would perform poorly and local adjustments are still required but that a common conserved core network of BCR downstream signaling exists.

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PMC9046263

The potential role of HML-6 as a driver of GBM oncogenesis may center on its unique gene product, ERVK3-1.

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PMC11746942

Additionally, activated STAT3 binds to the S1PR3 promoter and upregulates its expression, creating a positive feedback loop to perpetuate the hyperproliferation and inflammatory state in psoriasis.

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PMC11607638

Male Sprague–Dawley (RRID:RGD‐70508) rats (250–450 g in body weight) were killed by asphyxia in 100% CO2.

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PMC6803987

3TC was obtained from Yuanye Bio-Technology & Co Ltd. (Shanghai, China).

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PMC9429973

A prior history of MDS or MDS/MPN was documented in 20% (8/41) of SF3B1 patients.

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PMC10222971

In Spain, this disease constitutes the second leading cause of death (25.2%) after those caused by diseases of the circulatory system (26.4%) in 2021 .

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PMC11731161

The detailed information of patients is listed in supplementary Table S1.

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PMC11753949

Hippocampal neurons were transfected on DIV11–13 using the CalPhos Mammalian Transfection kit (Takara) according to manufacturer’s instructions, and imaged at DIV16–28 either live or after fixation.

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PMC9370419

The integrated genes included the controllable TCE (tetracycline response element and minimal CMV-promoter enhanced) promoter, which enhanced the expression of HiBiT-HBx in a tetracycline-inducible manner, whereas the rTetR sequence expressed the rtTA protein and the hygromycin gene.

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PMC10565698

This work was financially supported by 10.13039/501100018557Nantong Science and Technology Project (MS22021001), 10.13039/100016086Suzhou Special project of diagnosis and treatment technology for key clinical diseases (LCZX202204).

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PMC5941560

Overlaps between the duplications, long insertions, and long deletions from Jurkat and DGV/1000Genomes were counted if there was greater than 25% reciprocal overlap.

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PMC11047729

In this study, we will discuss the natural inhibitors of telomerase, which are included in Table 1 and Table 2, and show their potential as novel mono- and multitherapy ingredients.

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PMC11345828

The resultant diastereomers are separable by high-performance liquid chromatography (HPLC), thermally stable (no interconversion observed at 120 °C for 72 h), and can be used to access either atropisomer of the final compounds.

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PMC9429973

The mutational signature was performed with SignatureAnalyzer software.

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PMC11711063

In contrast, colony formation was moderately inhibited by Bex or Carv, and more pronounced by the combination of Bex + Carv in all cell lines (Figure 5A–C, second graphs).

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PMC11773391

The authors have nothing to report.

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PMC8494202

Subsequently, the membrane was incubated with primary specific antibodies for cell cycle-related proteins, including CDK4 (1 : 1000, Proteintech, Chicago, IL, USA), CCNB1 (1 : 1000, Proteintech), CCND1 (1 : 1000, Proteintech), CCNE1 (1 : 1000, Proteintech), and GAPDH (1 : 1000, Proteintech), followed by three washes wi...

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PMC9429973

The majority of these patients is unfit for aggressive treatment protocols and the lack of randomized trials in this category makes it difficult to choose the best regimen.

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PMC9429973

Efflux activity was examined using combination of mitoxantrone (ABCB1 substrate) and midostaurin (ABCB1/FLT3 inhibitor).

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PMC9429973

Enteral nutritional support was associated with a reduced frequency of nasogastric tube insertion when adjusted for age, sex, and baseline BMI: OR=0.16, 95%CI 0.03-0.83, p=0.029.

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PMC10723784

The cytotoxic effect of 30 μM of CBD alone and in combination with tocopherol (1 nM to 100 μM) on the A2780 and A2780/CP70 cell line after 24 and 48 h contact time.

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PMC8557138

In contrast, dopamine has been shown to inhibit the expression of VEGF and MMP9 (Chakroborty et al. 2009).

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PMC11519077

IL-1β-induced Caco-2 cells 3.

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PMC9429973

Health-state utility weights and disutilities of bleeds were obtained from published literature.

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PMC10654497

In addition, we calculated the best risk score cutoff value using the R software package “maxstat” and adjusted the minimum and maximum numbers of grouped samples to be larger than 25% and less than 75%, respectively.

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PMC6450504

Following the monolayer studies, penetration of PEIPOS in the spheroid model was evaluated (Figure 3).

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PMC9429973

Dynamic BH3 profiling using synthetic BH3-peptides was performed to determine the dependency of ALL cells on BCL-2 family proteins.

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PMC9412887

Selenium can promote the generation of CD8+ T cells and increase the secretion of perforin and granulation enzyme .

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PMC11774747

Recombinant human interleukine-2 (IL-2) is the most common cytokine promoting T cell survival and proliferation.

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PMC11126803

Not all of these noncoding RNAs can regulate ERβ expression.

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PMC11753435

We also simultaneously cotransfected 10 individual peptides designed with PepPrCLIP (table S3), which were fused to CHIPΔTPR-IRES-TagBFP, and monitored the expression of the SS18-SSX1 fusion via the linked mCherry reporter (see schematic in Fig. 5B).

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PMC10196713

After fixation, cells were incubated with antibodies against Fdx1 (1:100; cat.

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PMC10142392

The micelles with PVP chains with seven arms on the outside showed the lowest amount of protein adsorption and the best stability in media, demonstrating the effect of the number of arms on encapsulation parameters.

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PMC11483468

Then, an Acx primer [5'-(CCCTTA) 3CCCTAA-3'] was added.

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PMC11391695

Additionally, western blot analyses indicated a 50% reduction in the expression of the ACYP2 protein in HCC tissues relative to the neighboring normal tissues (Fig. 1C).

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PMC11721064

Total RNA was extracted using TRIzol Reagent (Thermo Fisher Scientific) and subsequently converted to cDNA using a reverse transcription kit (GeneCopoeia, Rockville, MD, USA).

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PMC11095939

Notably, the modest but significant changes in liver regeneration caused by the manipulation of Mecp2 in the first 2 d after PHx disappeared 5 d post-PHx (Figure 2—figure supplement 1H–J), indicating the involvement of Mecp2 in not only quiescence exit but also in later stages of cell proliferation.

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PMC5673060

Data were further analysed using Microsoft Office Excel 2010 and Perseus (version 1.5.5.3).

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PMC10798140

As a result, this chemical is a good option for anticancer therapy.

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PMC5173112

Complementarily, forced expression of USP21 leads to increase of tumorigenic properties.

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PMC11310713

Sections were then treated with peroxidase-blocking solution (DAKO, Carpinteria, CA, USA) and incubated with primary antibodies at 4°C overnight: anti-p53 (ab131442, Abcam, Cambridge, UK), anti-PTEN (ab267787, Abcam), and anti-KI67 (NB500-170, Novus Biologicals, Littleton, CO, USA).

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PMC9429973

A total of 342 SAA patients were enrolled, with 183 patients receiving HID SCT and 159 receiving ISD SCT.

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PMC9429973

Medical/surgical history (odds ratio[OR], 5.16; 95% CI, 1.91–13.92; P=0.001), splenectomy (OR, 2.86; 95% CI, 1.16–7.02; P=0.022), and >24 transfusion events in 48 weeks prior to enrollment (OR, 2.78; 95% CI, 1.15–6.74; P=0.023) were associated with increased odds for developing treatment-related complications.

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PMC3931643

Nevertheless, the induced binding of 4EBP2 to eIF4E seemed to be ineffective at displacing eIF4G and was therefore unable to compensate for loss of 4EBP1.

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PMC5963610

These facts combined to the low toxicity of anti-EGFR mAb, Nimotuzumab and the NGcGM3/VSSP vaccine , justify further exploration in clinical trials of the combination.

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