PMCID string | Sentences string | ner list |
|---|---|---|
PMC11706776 | GSE94278 contains Bigwig files of normalized ChIP-Seq values of MSCs transfected with a control plasmid, a FLI1 plasmid, and an EWS::FLI1 plasmid. | [
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PMC8584666 | However, it has been reported that GPI-80 mRNA expression was upregulated in androgen-deprived prostate cancer cells (PC3 cells) as well as in the metastatic human esophageal squamous cell carcinoma cell line (T.Tn-AT1 cells) . | [
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PMC11758416 | Be sure to plate excess wells of T cells if T cell death following stimulation is expected, see problem 2 below. | [
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PMC3203927 | Oxygen concentration in 3D tissues depends on the balance between oxygen delivery and consumption. | [
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PMC11721277 | Characteristic signals of protons from methylene groups, amide groups, and a tert-butoxycarbonyl protecting group were observed in the H NMR spectrum (Figure S3). | [
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PMC11424574 | The GoScript reverse transcription mix kit (Promega, Madison, WI, USA) was used to reverse transcribe the RNA (1 μg) into cDNA. | [
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PMC11222184 | The expressions of genes associated with cellular senescence, BMI1, ETS2, IGFBP7, MAP2K3, SOD1, changed after XL-888 treatment. | [
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PMC9100622 | Firstly, we demonstrate that, via the regulation of Ewing-susceptibility gene EGR2, EWSR1-FLI1 up-regulates various genes encoding enzymes of the pathway. | [
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PMC11422150 | The previous report showed that NO generated in the CNS during inflammation induced neuronal death through glutamate release, leading to excitotoxic cell death. | [
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PMC11740508 | Foci numbers per nucleus were analyzed using Prism® (GraphPad). | [
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PMC9429973 | 2-year overall survival (OS) rate was 87%. | [
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PMC11499381 | When co-expressed, these constructs created a receptor that was able to recruit β-arrestin in response to αCGRP stimulation, and a functional eYFP protein which could be detected by fluorescence microscopy. | [
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PMC6267596 | More specifically GO term related to MAPK cascade (GO:0000165, P = 4.72E-06, Count = 6), signal transduction (GO:0007165, P =0.00480611, Count = 6), positive regulation of PI3K signaling (GO:0014068, P = 4.69E-07, Count = 5) are identified with other related GO IDs (Table 1b). | [
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PMC6267596 | Top 20 enriched GO terms including negative regulation of apoptosis and positive regulation for cell proliferation respectively for U2932 and VAL cell lines. ( | [
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PMC8358176 | After treatment of rats with CNTs, no expression changes were observed in the mentioned genes. | [
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PMC10047551 | Programmed death-ligands 1 and 2 (PD-L1 and PD-L2) are ligands for PD-1, and the PD-1/PD-ligand axis is involved in maintaining peripheral and central immune cell tolerance . | [
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PMC11621565 | Further, a special emphasis falls on the microbiota and its metabolites. | [
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PMC11464609 | While the panel targets a broad range of viral species, bornaviruses are not specifically enriched. | [
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PMC10507284 | The results of GO enrichment analysis between the different TROAP expression cohorts (using c5.all.v5.1.symbols.gmt). ( | [
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PMC11269933 | The Glucose uptake assay (Fluorometric, Direct Glucose) (Abcam, USA) was used to perform the glucose uptake assay. | [
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PMC11334037 | This investigation further demonstrated the activation of IGF1R signaling by IGF2 in GIST cells. | [
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PMC11786767 | Left: Representative images. | [
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PMC11659921 | Construction and validation of prognostic models for angiogenesis and stemness. ( | [
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PMC8427838 | D Whole cell lysates from 786-0 cells expressing EV or TMIGD1 were incubated with anti-TMIGD1 antibody and immunoprecipitated proteins were detected via Western blot analysis using an anti-moesin antibody. | [
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PMC11806182 | Each cell represents the correlation between the expression of specific modules and distinct clinical parameters, with numerical values in brackets indicating the statistical significance of the correlation Gene co-expression analysis revealed four distinct gene co-expression modules (Fig. 4F). | [
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PMC9429973 | Pts on gilteritinib had longer EFS than pts on SC (median EFS 2.8 vs 0.6 mo; HR 0.551 [95% CI: 0.395, 0.769]; P=0.00004). | [
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PMC11474209 | It is a widely recognized algal toxin as it causes toxic effects on mitochondrial machinery, prompting DNA double-strand breaks, producing reactive oxygen species (ROS), impairment of DNA repair, and elevated inflammatory cytokine response leading to various diseases, including cancer . | [
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PMC8427838 | A Amino acid sequence homology of human and mouse TMIGD1 and sequence of the known moesin binding receptors. | [
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PMC11781181 | The RNA-Seq analysis was performed to identify differentially expressed genes (DEGs) in the keratinocyte of the exosome-treated group to investigate better the effect of plasma-derived exosome from patients with SJS/TEN. | [
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PMC11752767 | Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to metastasis and drug resistance. | [
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PMC11525028 | Thus, ATF4 promoted the transcription of asparagine synthetase (ASNS), which catalyzes asparagine (Asn) biosynthesis. | [
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PMC9429973 | As of the data cut-off, 5 of 6 pts completed the 28-day DLT period. | [
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PMC11547917 | Caco-2 cells were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA) and expanded in DMEM cell culture media. | [
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PMC11599565 | The transcriptome results were analysed using different bioinformatic tools like: Dr. Tom, the Ensembl BioMart tool and gene expression clustering analysis were performed using the Enrichr platform. | [
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PMC11621565 | The impedance measurements presented in the images are from the moment of treatment addition, while the dopaminergic differentiation was not shown here. | [
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PMC11472569 | Meanwhile, the TMDs form a flexible channel with 12 transmembrane helices responsible for substrate recognition and transportation. | [
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PMC11694625 | After cells were incubated continuously for 48 h, MTT solution (20 μL, 5 mg mL) was added into each well for another 4 h. Finally, DMSO (150 μL) was added into each well, and the absorbance of the converted dye in living cells was measured at a wavelength of 570 nm (ref. | [
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PMC9429973 | Mean (standard deviation [SD]) BL Hb, total bilirubin and lactate dehydrogenase (LDH) were 8.1 (1.2) g/dL, 40.1 (26.2) μmol/L, and 272.4 (121.7) U/L, respectively. | [
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PMC11565047 | None. | [
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PMC11441402 | The propidium iodide (PI) flow cytometric assay has been widely used for the evaluation of cell death in different experimental models (Riccardi and Nicoletti 2006). | [
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PMC9429973 | Image: Summary/Conclusion: 1. | [
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PMC11791432 | Subsequently, the stably U87 cell lines were selected for following experiments according to a previous study . | [
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PMC11754784 | A set of differential equations following the kinetic profile was formulated and provided in Supplementary Note 3. | [
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PMC11670954 | Furthermore, numerous studies have indicated that BA effectively enhances intestinal barrier integrity by promoting the expression of Claudin 2 and reducing intestinal permeability through an IL-10 receptor-dependent mechanism . | [
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PMC11551844 | The cytotoxicity of AuNPs-JDE decreased in A172 and HaCaT cells but increased in TERA1, HeLa and HepG2 cells compared to JDE. | [
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PMC11402217 | ns = no significance. | [
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] |
PMC11577421 | The uptake of NP_BSA, NP_BSA+, and NP_FBS was also investigated in HeLa cells. | [
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PMC9532503 | The routinely used feed additives are Uridine (U), Manganese chloride (M), and Galactose (G) in various strengths. | [
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PMC11700247 | CD45.2/CD3 T cells isolated from treated mice stimulated with AH1 peptide and incubated with A20 tumor cells. ( | [
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PMC9429973 | The median duration of Ruxo exposure was 7months [0-37]. | [
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PMC11770199 | Cells were imaged with a fluorescence microscope after incubating at 37 °C for 16 h, and nuclei were stained with Hoechst 33342. | [
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PMC11391695 | The telomerase activity expressed via TERT influences the length of telomeres and can serve as a valuable marker for the diagnosis and prognosis of diverse types of cancer [44–46]. | [
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PMC6461034 | Spectral counts are multiplied by the number of phosphomodifications of the pertinent peptide so as to account linearly for all phosphorylation activity impinging on the substrate protein. | [
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PMC11252553 | Various methods have been used to detect apoptosis based on morphological changes or dysfunction of different cell parts . | [
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PMC10976516 | Seyed-Khorrami et al.Measles virusAttenuated measles virus (MV) HU-191 strainIntratumoralIntratumoral injection with MV Hu-191 in a syngeneic model with subcutaneously transplanted A549 and LLC tumor cell lines caused clear tumor cell death and regression with increased T cell infiltration of TME.Zhao et al.Attenuated ... | [
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PMC11360263 | Early evidence has documented HCMV’s ability to induce the in vitro transformation of human embryonic lung fibroblasts and rodent fibroblasts . | [
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PMC11349530 | Conditioned media from pancreatic cancer cells and pancreatic stellate cells induced differentiation of myeloid-derived suppressor cells (MDSCs) and suppression of lymphocytes (14). | [
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... |
PMC9429973 | Methods: The analysis of the clinical course of primary myelofibrosis in a 28-year-old patient with high-risk thrombophilia was carried out: double heterozygous: Leiden mutation and mutation of the prothrombin G20210A gene. | [
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... |
PMC11762280 | H Representative images of H&E, TUNEL, MPO, MMP9, and F4/80 staining in DSF or vehicle treated mice after UVB irradiation. | [
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... |
PMC11377827 | For cell-surface staining, cells were washed in ice-cold PBS, incubated at 4 °C for 30 min with the primary antibody, washed with PBS and incubated with the appropriate secondary antibody at 4 °C for 30 min. | [
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... |
PMC11805741 | Their health benefits are mainly attributed to their immune system enhancement, antioxidant and anti-inflammatory activities (Bhatt and Patel 2020). | [
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PMC11301095 | An increase in IL-6 levels, concurrent with a decrease in IFN-γ production, is indicative of a dominant Th2 response . | [
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... |
PMC9370419 | HBx plays a momentous role in the HBV life cycle, which is essential for virus replication and cccDNA transactivation. | [
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"tokens": [
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PMC11637276 | Vectashield mounting medium with DAPI allowed the visualisation of the nuclei. | [
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PMC10914904 | This activation also triggers NF-kB, promoting the expression of proinflammatory cytokines such as interleukin 1 (IL-1) and TNFα [26–29]. | [
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"tokens": [
... |
PMC2118063 | Numbers indicate the fold change represented by the closed bars. | [
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PMC11706776 | Regarding the role of KCNN1 in a key function of tumor development, our results have shown that the silencing of KCNN1 expression decreases the ability of ES cells to form colonies and slows down the cell cycle. | [
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... |
PMC9429973 | These findings agree with previous reports that evidenced TH17/Treg ratio was higher in low risk MDS patients when compared with high risk. | [
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"tokens": [
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PMC11126803 | In this study, we aimed to elucidate whether the formation of VMs in RCC is related to the activation of ERβ, and to identify the signaling pathway associated with the ERβ-regulated VM formation. | [
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... |
PMC8041314 | Following the “clear positive hit” search, we defined “clear negative hits” (“Negative Pattern”) that did not account for multitarget inhibition: (i) the respective substructure must have occurred at least five times in the 1049 molecules of the dataset; (ii) the respective substructure did not account for one single t... | [
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... |
PMC11697703 | •The DOIs of key resources are listed in the key resources table. | [
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PMC11377827 | n = 3 biologically independent samples, mean ± sd. | [
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... |
PMC11638255 | Data are presented as mean, n = 2 biological replicates (healthy donors), one independent experiment. | [
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... |
PMC9429973 | A. Reiter, J. Gotlib, I. Álvarez-Twose, D. H. Radia, J. Luebke, P. J. Bobbili, A. Wang, C. Norregaard, S. Dimitrijević, E. Sullivan, M. Louie-Gao, J. Schwaab, I. A. Galinsky, C. Perkins, W. R. Sperr, P. Sriskandarajah, A. Chin, S. R. Sendhil, M. S. Duh, P. Valent, D. J. DeAngelo Department of Hematology and Oncology, U... | [
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"O",
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"O",
"O",
"O",
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... |
PMC10747139 | Although many studies have described the anticancer activity of Ru complexes, there are very few reports on their antiviral activity . | [
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"tokens": [
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... |
PMC11803149 | D-F) On day 8, OT-I T cells were co-cultured with B16-OVA cells at a ratio of 1 to 3. ( | [
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"tokens": [
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... |
PMC6684588 | SPR assays were carried out for ACE-083 more than three times, and these data represent means of two experiments performed on separate flow cells. | [
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"O",
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"tok... |
PMC9429973 | Image: Summary/Conclusion: The NIHR HIC Myeloma registry represents a research ready platform to integrate and analyse UK wide real word data. | [
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"O",
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"O",
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PMC9429973 | Real-world studies in several countries have shown increases in OS in recent years for patients with MM; up-to-date real-world data on MM survival in France are limited. | [
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... |
PMC10329237 | Statistical analysis One-way analysis of variance (ANOVA) was used to assess the statistical analyses after Tukey’s multiple comparisons, then Dunnett’s test for selected pairs if appropriate with Prism 8.0 (GraphPad Software, La Jolla, CA, USA). | [
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PMC10994876 | We observed that the overexpression of YAP5SA facilitates the progression of the cell cycle by inducing the transition from the G1 to S phase (Fig. 6). | [
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... |
PMC9429973 | Four patients were males and all of the patients were from Asian ethnicity. | [
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PMC7759933 | The surface area of at least 10 spheroids with the initial density of 3000 cells/spheroid and 6000 cells/spheroid was monitored during the time of cultivation (up to 12 and 4 days, respectively). | [
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"tags": [
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"O",
"O",
"O",
"O",
"O",
"O",
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... |
PMC11307990 | The results showed that the DNA nanotape-SUN exhibited a novel absorption peak at 430 nm compared with 6HB-DONs, which was consistent with the SUN absorption peak reported in the literature, indicating that DNA nanotapes successfully adsorb SUN. | [
{
"tags": [
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... |
PMC9429973 | Median OS was 15.7 (12.9-15.9, K-M) and 16.9 (11.9-46.6) months, respectively. | [
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"tokens": [
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PMC10123657 | Protein concentration was determined by turbidity measurement at 360 nm and then adjusted to 1 μg/μL with 0.2 M Tris pH 8. | [
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"O",
"O",
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"tokens": [
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PMC9243326 | We performed functional annotations on all the obtained transcripts in the four major databases, of which 91.86% of unigenes were successfully annotated and only 8.14% were unannotated. | [
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... |
PMC8740518 | The top 25 pathways with P-value <0.05 were selected based on enrichment ratio (i.e., observed hits/expected hits). | [
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PMC11588008 | The decrease in GSH can modulate cell death in many ways such as apoptosis and fragmentation DNA cleavage . | [
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"O",
"O",
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PMC11098378 | However, the wild-type arboviruses used in our study are already well-adapted for robust replication in mammalian host cells. | [
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PMC10222971 | Ali and co-workers evaluated the effect of antileishmanial activity of a series of naphthoquinones, including simple, oxygenated in the aromatic or quinonoid ring, dimeric and furanonaphthoquinones. | [
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PMC11656380 | PCR was performed using a StepOnePlus Real-Time PCR system (Thermo Fisher Scientific, Waltham, MA). | [
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PMC9780037 | Attaining these two critical goals demands the detailed characterization of the biochemical alterations of cancer cells. | [
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PMC6889484 | To test whether the A3 and 3G portions of A3G-D128K retained any antiviral activity, virions produced from eYFPip, A3dr(DK), and 3Gdr(DK) vectors were normalized for p24 capsid protein (CA) amounts and used to transduce 293T cells (Figure 1D). | [
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... |
PMC10094712 | First, it was found that TRAF2 (a factor associated with the TNF receptor) interacts with pro-caspase-12 under ER stress , which activates caspase-9, which forms apoptosomes that are necessary for the activation of effector caspase-3 . | [
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... |
PMC11769522 | Other assays, such as the Luminex multiplex assay, can usually detect lower concentrations of cytokines. | [
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PMC10969097 | The team of Gou et al. used polysaccharides of Trametes robiniophila Murr obtained commercially . | [
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PMC9000591 | In the case of SE3, Mino cells exhibited a similar reaction to SE2, while U266 cells were surprisingly sensitive, with this fraction increasing to 53.0%. | [
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PMC11371627 | Genetic analysis of blood was performed using a customised myopathy multi-gene panel [Twist Version one analysed with varvis (version 1.19)] covering candidate genes for myopathy and muscular dystrophy. | [
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"tags": [
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... |
PMC11794588 | Its cytotoxicity is linked to its ability to disrupt cellular membranes or induce apoptosis. | [
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