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PMC9429973
Aims: We report two clinical cases.
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PMC9429973
Aims: Construct a computational model that enables BH3-mimetics to be tested in virtual DLBCL cell lines and accurately predicts cellular responses, as measured experimentally.
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PMC11462673
By conducting western blot and reverse transcription polymerase chain reaction (RT-PCR) analyses, we detected a substantial reduction in the expression of LDB1 at both the protein and RNA levels in cells transfected with LDB1 shRNAs in comparison to the control group (Fig. 2A, B, and C).
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PMC9318744
The purified RNA was then used for cDNA synthesis using the QuantiTect Reverse Transcription Kit (Qiagen, 205311).
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PMC11704135
Tumor cell proliferation, angiogenesis, and metastasis depend on these kinases.
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PMC11188874
G, Effect of sgRNA targeting HDAC6, HR23A, and HR23B on proteasome ChT-like activity in MMCLs.
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PMC11381192
Then, GO analysis revealed that CSI was involved in the enriched functions including mitotic nuclear division, sister chromosome segregation, organelle fission and spindle (Figure 2L).
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PMC9964654
The variations in LCs obtained using water or PBS were not as significant as those obtained with the change of the polymer and the gold-complex solubilization solvent.
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PMC9429973
Methods: We performed single-cell RNA sequencing (scRNA-seq) analysis of lineage-negative (Lin) CD34 hematopoietic stem and progenitor cells (HSPCs) and BM mononuclear cells (MNCs) isolated from RAS pathway mutant CMML pts (n=5 and 6, respectively) and age-matched healthy donors (HD; n=2 and 3, respectively).
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PMC9429973
Being a malignant transformation and proliferation of lymphoid progenitor cells in the bone marrow, blood and extra medullary sites, ALL represents a devastating disease when it occurs in adults.
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PMC9429973
AEs that were potentially immune-mediated, such as diarrhea, colitis, pneumonitis, and transaminitis, were observed at significantly lower incidences of occurrence.
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PMC11471157
The samples were hydrolyzed in hydrochloric acid containing 0.2 % phenol and 0.2 % sodium azide.
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PMC11544771
CPX treatment dose-dependently reduced the level of CDK4, which was apparently not altered by the addition of PRE.
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PMC11575040
In addition, the false-positive discovery rate was calculated using the FDR-corrected q value.
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PMC9592219
In the WGCNA analysis, TOP2A was mainly associated with DNA replication.
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PMC6643347
The ability to suppress the infection induced by the AZT-resistant strain was cell-dependent: judging from the 50% inhibitory concentration (IC50) values, SBF-HS was more efficient in PBMC than CEM-SS cells.
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PMC11519583
Scale bar: 25 μm.
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PMC8584666
Oxidative conditions are appropriate for tumorigenesis.
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PMC11471157
Dried fish, a product manufactured globally, is commonly consumed after undergoing a heating process .
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PMC11001582
In combination, these results show that COL6A1 is induced in neurons by neurodegenerative insults as a compensatory response, via TGF-β1.
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PMC11467964
The previous study and our results may explain the reason for the different prognoses of the different risk groups.
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PMC9429973
One-year overall survival (OS) and disease-free survival (DFS) were 77.8% and 61.2%.
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PMC9429973
Treatment is often challenging due to underlying organ dysfunction.
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PMC11629461
In the presence of Trolox‐C, miniSOG photodynamic action no longer induces any calcium increases in miniSOG‐NOX5‐CHO‐K1 cells.
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PMC6337547
Among them, salvianolic acid B was positively correlated with DPPH scavenging activity (correlation coefficient (r) = 0.693, P < 0.05), reducing ability (r = 0.748, P < 0.01), and inhibition of linoleic acid oxidation (r = 0.804, P < 0.01).
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PMC9429973
A single dose of KO7CAR-T cells was infused to patients at low dose (1.5~5x10 cells/kg, n=8), medium dose (1x10 cells/kg, n=6) or high dose (2x10 cells/kg, n=1).
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PMC10212663
The findings revealed significant prognostic differences between advanced KRAS‐mt LUAD patients with low or high levels of RANKL expression, whereas this difference was not significant between advanced KRAS‐wt ones, suggesting that RANKL plays a poor prognostic role mainly in the KRAS‐mt setting (Figure 2(c)–(e)).
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PMC11755624
Dysregulation of these molecules is frequently linked to a range of pathological conditions, including psoriasis.
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PMC3765139
gp100 = melanosomal matrix protein gp100; tyrosinase = key enzyme in melanin biosynthesis; MART-1 = Melan-A/MART-1 = melanoma antigen recognized by T cells; MAGE-A3 = melanoma antigen-A3 family, NY-ESO = cancer/testis antigen (see text); (+) = moderate expression; (+ +) = strong expression; (-) = no expression detectab...
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PMC11633763
Therefore, a comprehensive understanding of the pathophysiology of osteosarcoma from a metabolic perspective may lead to the development of novel treatment approaches.
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PMC9436459
Wittiorumin G (127) obtained from M. wittiorum is the only type E MDAAs with cis–trans configuration .
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PMC11337594
Given that TER inhibited A375 cells primarily during the G2 and S phases, when the cells had already completed Ki67 accumulation, the expression of Ki67 detected under immunofluorescence was not affected and even exhibited a tendency to increase.
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PMC9429973
In the CML-LBP cohort, the 2-year EFS was 33% and the 2-year OS was 60%.
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PMC9429973
NX-1607 will be given orally once daily at doses ranging from 5 to 100 mg in up to 6 dose levels.
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PMC9429973
The initial daily dose of eltrombopag is 25 mg and could be adjusted to 75 mg as maximum to maintain platelet counts between 50 × 10/L and 150 × 10/L. Patients were assessed for platelet counts weekly in Stage1 and every 4 weeks in the Stage2.
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PMC11696576
c Gene set enrichment analysis based on a ranking of Pearson’s correlation with compound activities performed against the Oncogenic signatures collection (C6) in MSigDB.
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PMC11483468
GST-TAT-LPTS39 induced apoptosis of QGY-7701 cells in a time-dependent manner. (
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PMC10094712
In rare cases, it is possible to choose conditions for the synthesis of native forms of selenoproteins in preparative amounts, which is explained by the peculiarities of recognition of the selenocysteine codon and differences in cis- and trans-active factors in bacterial and eukaryotic systems .
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PMC5308810
Cells (5x10) were suspended in media containing 10% (w/v) FBS and 0.35% (w/v) agar and seeded in pre-solidified media containing 0.75% (w/v) agar containing 10% (w/v) FBS in on 6-well plates.
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PMC9777812
To identify the interactions between bta-miR-106b and target genes, 3′UTR fragments of the targets were amplified by PCR and ligated into the pmirGLO Dual-Luciferase microRNAs Target Expression Vector (Promega) using NheI and XhoI restriction enzymes.
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PMC5417661
Cell population growth curvatures were determined using the IncuCyte software based on the cell confluency.
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PMC11588085
As part of our investigation into the molecular mechanisms that lead to the phenotypic changes caused by XIST KD, we analyzed the transcriptomes of OVCAR3-KRAB clonal cells by RNA sequencing (RNA-seq).
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PMC11461874
After the digestion, an equal volume of ethyl acetate was added to the samples, and the mixture was acidified with 0.5% TFA and mixed well to transfer the detergents into the organic phase.
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PMC11543935
The fluorescence intensity was measured at 560 λ excitation and 590 λ emission using an Infinite 200 Pro microplate reader (Tecan Group Ltd., Switzerland).
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PMC10968586
Also, OLE and HT modulatory activity on immune cells deserves further investigation.
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PMC11237030
Characterization of CHO-K1/AQP5 clones.
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PMC11322866
The beads were then washed with lysis buffer, proteins were eluted by boiling for 5 min in SDS-PAGE sample loading buffer, and western blot analysis was performed.
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PMC11371747
l-LV showed a 2-fold modulation in WiDr, HT29, SW948 and SW1398 cells; however, as shown very clearly in Supplementary Figure S2 d-LV was ineffective in all cell lines in modulating 5FU sensitivity, while in WiDr-LF cells the IC50 value for 5FU even increased 1.5-fold by d-LV.
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PMC11359735
CSP was eluted with 1% SDS in 0.1 M glycine pH 1.8, neutralized with 1.5 M Tris-HCl pH 8.8, and run on a 7.5% SDS-polyacrylamide gel under nonreducing conditions.
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PMC9429973
Summary/Conclusion: This SLR synthesized real-world outcomes associated with complement C5 inhibition in patients with PNH and demonstrated consistent effectiveness of eculizumab beyond the clinical trial setting.
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PMC10969097
Cen et al. demonstrated that SBSGL was able to sensitise ovarian cancer to cisplatin, both in in vivo and in vitro experiments.
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PMC11587606
A, B) The Tyrosine phosphorylation of PKCζ (Tyr-p-PKCζ) and importin β1 protein expression in (A) MCF10A/GFP, MCF10A/RH and (B) Dox-treated TetON-RH cells/acini (n = 3). (
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PMC9454852
Currently, the standard therapy for MPM is based on the use of a combination strategy (platinum–pemetrexed chemotherapy ) where two different drugs are combined.
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PMC11615828
Here, a new method called RIVET (Rapid Immobilization of target Vesicles on Engaged Tracks) is presented.
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PMC11792766
The NRU assay (Figure 1a) showed no decrease in cell viability with increasing ethanol concentrations up to 2% v/v.
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PMC11792090
To activate IL-7 signaling independently of IL-7, we introduced a mutant form of the IL-7 receptor (IL-7R) transmembrane domain, which has been reported to drive constitutive signaling via JAK1 (36, 37), along with the intracellular domain of IL-7R into UCAR-T cells.
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PMC9429973
OFT were negative in 4 patients (17.3%), of which 50% were in SLC41 group and 50% in SPTB group, being one of the mutations known with uncertain clinical degree and novel mutations in the other 3 patients, with pathological significance in one patient and with probably pathological repercussion in the other two.
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PMC8345486
3-Amino-7-dimethylamino-2-methylphenazine hydrochloride (neutral red) was purchased from Abcam (Cambridge, UK).
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PMC9429973
6-year nonrelapse mortality was 35% (21-49%) for the TP53 group versus 27% (22-32%) for the non-TP53 group (P=0.16) and 6-year incidence of relapse was 26% (13-39%) for the TP53 group versus 18% (14-21%) for the non-TP53 group (P=0.09).
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PMC11590005
The MRS was validated in Brazil in 2006 to analyse local racial democracy .
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PMC9429973
K.-L. Koster, N.-M. Messerich, T. Volken, S. Cogliatti, T. Lehmann, A. Holbro, R. Benz, L. Graf, I. Demmer, W. Jochum, T. Silzle Clinic for Medical Oncology and Hematology; Departement of Intensive Care, Cantonal Hospital St. Gallen, St. Gallen; Institute of Public Health, ZHAW School of Health Sciences, Winterthur; In...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11474209
As a result, because of membrane potential, cation molecules are drawn to mitochondria and preferentially aggregate there.
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PMC9429973
F. de Arriba de la Fuente, M. T. Hernández Garcia, J. A. Soler Campos, H. R. Susana, M. J. Moreno Belmonte, M. González Pardo, M. Gironella Mesa, M. Casanova Espinosa Hematology, Hospital General Universitario Morales Meseguer, Murcia; Hematology, Complejo Hospitalario Universitario de Canarias, Santa Cruz de Tenerife;...
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PMC11687663
Once on the platform, we input the simplified molecular-input line-entry system (SMILES) notation of the compound of interest.
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PMC10976516
PAMPs, TAAs, DAMPs, and cytokines work synergistically to promote antigen-presenting cell (APC) maturation, which in turn primes CD4+ and CD8+ T lymphocytes for the adaptive host immune response through cross-presentation.
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PMC10823017
The flow cytometry based Annexin V APC assay kits (601410) were purchased from BioVision Inc (Milpitas, CA) and Cayman Chemicals (Ann Arbor, MI), respectively.
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PMC9454178
E Immunoblotting analysis showed that the expression of c-KIT and downstream ERK and AKT signalling pathway components was inhibited following THZ1 treatment at the indicated concentration in GIST-T1 and GIST-882 cells for 24 h. F Immunoblotting analysis indicated that combination treatment with imatinib and THZ1 enhan...
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PMC11612794
DNA was stained with DAPI.
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PMC11119602
Here, we show that the treatment of HepG2 cells with cisplatin causes a redistribution of TG2-S from a membrane-associated assembly to a cytoplasmic pool, an effect that was absent in cells that had been previously made chemoresistant to cisplatin.
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PMC10988555
The electronic absorption spectra of the four CoCp complexes (1–4) were acquired in dichloromethane solutions (1 × 10–1 × 10 M) at room temperature.
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PMC11190538
Anti-human liver and colon carcinomas that exceeded Doxorubicin with very low cytotoxicity against normal cell lines were detected.
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PMC11469524
This approach combines experimental quantitative perturbation data sets with a mechanistic computational modeling approach derived from MRA.
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PMC10502403
For metabolic inhibition experiments, RPMI 1640 (glucose-free) medium, 2-DG (Sigma–Aldrich Co. LLC, St. Louis, MO), etomoxir, CB-839 (Cayman Chemical, Ann Arbor, MI), and oligomycin (Abcam, Cambridge, UK) were used.
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PMC11092418
These plates were then fixed as mentioned above, stained with 0.04% (w/v) SRB in 1% acetic acid for 1 h, washed thoroughly with 1% acetic acid and left to air dry overnight.
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PMC11473843
A549 (CCL-185), HEK293T (CRL-11268) and Phoenix-Ampho cells (CRL-3213) cell lines were purchased from ATCC.
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PMC6312945
P<0.05 was considered to indicate a statistically significant difference.
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PMC10165258
Time lapse of a spheroid, showing its growth and cell death (stained with PI dye) over days.
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PMC11674834
CHO cells expressing NAT1*4 exhibited significantly (p < 0.001) higher 3,4-DMA N-acetylation rates than CHO cells expressing NAT1*14B both in vitro and in situ.
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PMC11725127
The ligand GA was prepared by LigPrep (Schrödinger LLC, 2020) and USP2 was prepared by Protein Prepare Wizard (Schrödinger LLC, 2020).
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PMC11802855
However, no significant correlation was found between CXCL7 and MYC gene expression.
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PMC11377827
The coverslips were stained with 1:100 of anti-USP43, or anti-HIF-1α primary antibodies at 4 °C overnight, then washed five times with 1x DPBS and counterstained with 1:400 anti-mouse 647 nm, or anti-rabbit 488 nm Alexa-Fluor™ secondary antibodies for 1.5 h at room temperature.
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PMC11655536
Approximately 588,000 people worldwide are diagnosed in MM every year [1–3].
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PMC10578720
The results showed that expression of major histocompatibility complex class II by macrophages was elevated after HBV stimulation, a further increase under DCA administration (Figure 7H, upper).
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PMC11740508
A–F Xenografts recieved 0.1 mg/kg talazoparib (Cat. #
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PMC9429973
However, the overall QoL of Chinese thalassemia patients and its affecting factors remain unclear.
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PMC11762280
The statistic of epidermal thickness and average optical density of TUNEL positive staining were analyzed (n = 8).
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PMC11628904
Therefore, we supplemented normal E3 medium with NaCl to an osmolarity of 135 mOsm in order to reduce, but not eliminate, keratinocyte motility.
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PMC11297139
As in the case of ΔDD-rescued mutant, this substitution-based phase separation failed to rescue proliferative and invasive phenotypes (Supplementary Fig. 8a, b).
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PMC11806818
The structure of MIL-101(Fe) gives MoS2 a large specific surface area, which is conducive to modifying probes on the outside of the hybridized nanozymes.
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PMC8170755
Our results showed that epigenetic regulation of CD44v6, Nm23-H1, MMP-2, and MMP-9 might be involved in the pathogenesis and metastasis of lung cancer.
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PMC11612794
Quantification data of GFP-Dsn1 signals at kinetochores in mitotic cells shown in (B).
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PMC11786704
All reagents and materials were used without further purification.
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PMC11740207
In continuously growing cell lines, for the first time, our team’s follow-up research on leukemia, lung cancer, and healthy embryonic kidney cells revealed stages that resembles very small precursor stem cells.
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PMC11240571
In addition, exosomal PD-L1 has been associated with poor prognosis in patients with pancreatic ductal adenocarcinoma .
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PMC11670407
Subsequently, sgRNA and Cas9 protein complexes were electro-transfected into 143B cells for knockout (KO).
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PMC11092382
In conclusion, sophocarpine represents a promising drug candidate that can serve as a key monomer or fundamental framework for developing novel antiparasitic drugs; hence, further investigations are necessary to elucidate its relevant pharmacological effects and mechanisms of action.
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PMC11696576
P-values were determined using RM-one way ANOVA with Dunnett’s correction for multiple comparisons.
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PMC10578720
Relative mRNA levels are presented as the mean ± SD, n=6, *=p<0.05, **p<0.01, ****p<0.0001 (1-way ANOVA with Tukey post hoc test). (
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PMC7802142
The uptake of 293-NV by DPCs was confirmed by fluorescence images (Additional file 3: Fig. S3a, b).
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PMC11461874
Briefly, mouse livers were collected every 4 h from 26 h after the beginning of the DD condition (expressed as projected CT).
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