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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
In all cases it was grade 1-2 and manifested at the first administration of the drug, after 4, 32 and 10 hours respectively, from infusion initiation.
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PMC9429973
Summary/Conclusion: Continuous GATA3-R276Q has a detrimental effect on T cell development in vitro.
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PMC11724582
YAP/TAZ are two highly related transcriptional activators that are expressed in a variety of solid tumors; these activators do not contain DNA-binding domains and cannot bind to DNA; therefore, they regulate cell physiological functions by translocating from the cytoplasm to the nucleus and binding to DNA-binding trans...
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PMC9952933
The cell suspension (200 µL) was transferred in wells of a 24-well plate and treated with CAP or argon for 10 s. As a positive control, the cells were treated with 500 µM H2O2.
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PMC10607604
Compared with parental KURAMOCHI cells, the expression levels of SLUG, ZEB-1, SNAIL, and ZEB-2 were increased by 2.3 to 4.5 times, by 1.6 to 2.3 times, by 1.4 to 2.2 times, and by 1.4 to 1.8 times, respectively, in the Kura-A2, Kura-A3, and Kura-B1 clones.
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PMC9429973
In 2 events, pathogens were detected by conventional diagnostics but NGS-based was negative.
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PMC10578720
Data presented as the mean ± SD, n=3, ns=p>0.05, **p<0.01, ***p<0.001, ****p<0.0001 (1-way ANOVA with Tukey post hoc test).
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PMC11400680
The first group is semantic segmentation, which separates image pixels into foreground objects (i.e., regions of interest for example cells and nucleus in this study) and unwanted background.
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PMC11727145
The slides were then incubated overnight at 4 °C with the primary antibody corresponding to the different tested proteins (Table 2).
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PMC11087301
Various transcription factors and miRNAs have been involved in the molecular insights interlinking EMT to the acquisition of stem cell features, even though the accurate molecular streams remain largely undetermined.
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PMC9919300
Furthermore, this study improved our understanding of the antisteatosis and hepatoprotective properties of a curcumin and andrographolide combination.
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PMC10734950
Hoechst fluorescent dye is able to permeate both living and dead cells when exposed for 2 h before reading, providing the total number of cells .
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PMC11730320
Notably, cells lacking the TCRβ chain at the DN3 stage, instead expressing TCRγ and TCRδ genes, are exported to the periphery as γδ lineage T cells.
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PMC10891340
Therefore, we used DAPI staining to observe the changes in the nucleus, the expression of blue fluorescence increased under infection conditions.
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PMC11052306
No clear trends depending on the nature of the pyridine–imine substituent could be deduced from these results.
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PMC9429973
Confocal microscopy and transmission electron microscopy were used to observe the PPF and cytoskeleton structure of ITP MKs.
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PMC9429973
We then examined these patients in more detail to ascertain risk factors for mortality, and how this has changed over the course of the pandemic.
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PMC5916734
ELISA measurement of FIX concentration The FIX concentration was measured using rabbit anti-FIX polyclonal antibodies (LifeSpan BioSciences, USA) (50 ng/well) as an immobilized antibody according to the procedure described in .
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PMC9429973
Patients who achieve CR/CRu/PR and are eligible for autologous stem cell transplantation (ASCT) will undergo ASCT, while patients who are not eligible for ASCT will directly receive penpulimab and lenalidomide as maintenance treatment.
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PMC6181431
46% of the somatic variants identified were clonal in both the pre-treatment and post-treatment samples, while 25% of variants were not seen in the pre-treatment sample but were clonal in the post-treatment sample (S2 Table).
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PMC6835762
This was a significant improvement compared to previous reports of human serum albumin-MTX conjugates which were only one three hundredth the potency of free MTX.
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PMC11349530
Various types of immune cells are also capable of producing PD-L1, which is part of the autoregulation of the immune response, particularly during inflammation (81).
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PMC11144200
In addition to serve as an antitumor antibody drug, Nb has also been reported to have the potential to be used in the construction of trispecific and CAR T cells .
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PMC9817179
Consistent with simulations, live-cell single-molecule imaging experiments showed that a fast overall rate of fixation relative to protein–protein interaction dynamics can minimize fixation artifacts.
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PMC11468365
The maximum number of epochs for training is set at 500, with a batch size of 64.
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PMC11697703
miR-193b and miR-365 cooperatively regulate spine density (A) Dendritic segments of neurons expressing single miR-scramble sequence (miR-Cnt), miR-365, miR-193b, miR-scramble sequences of miR-193b and miR-365 (miR-Cnt-double), or miR-193b-miR-365.
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PMC10253973
These are sometimes not available for Ru or made ad hoc without sufficient testing.
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PMC9847912
IC50 values for the HIV-1 isolates were calculated using a 4-factor regression model in GraphPad Prism version 6.0h.
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PMC5673955
C, D) Histograms of proportions of cells in different phases of cell cycle. (
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PMC10079526
In vivo experiments combining TAK981 (25 mg/kg) and 5-Aza-2’ (2.5 mg/kg) showed a significant reduction in outgrowth of Burkitt lymphoma in an orthotopic xenograft model.
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PMC11350568
By contrast, a certain amount of AptG-2 fell off from the cells, revealing that the AptG-2 was not able to form a stable TMPDS as AptG-1, thus indicating that AptG-1 possesses a superior binding ability over AptG-2.
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PMC11739484
By using HPA, we were able to validate the findings from mRNA expression analysis with protein-level data across SKCM and normal samples.
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PMC11687663
However, the compound having high binding affinity (B12) showed the optimal LogP value of 2.15.
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PMC11543853
Microfilaments and membranes were segmented manually.
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PMC11656048
Cells were fixed by 4% PFA and stained by 0.1% crystal violet (Solarbio, China).
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PMC11566417
PowerTrack SYBR Green MasterMix (Thermo Fisher) was used for the PCR reaction, which was performed using a QuantStudio3 thermal cycler (Thermo Fisher).
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PMC11754784
100 µl of 500 nM purified samples (DNA claws, DNA cages, DNPs) were prepared to measure the hydrodynamic diameter with Zetasizer Nano-ZS (Malvern Instruments).
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PMC11545737
Inhibition of several mediators of pyroptosis is attracting increasing interest in the treatment of inflammatory diseases, and the safety and efficacy of some pyroptosis inhibitors are being evaluated in clinical trials.
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PMC11747467
After exposing cells to different drug concentrations, we found that ART could dose-dependently inhibit cell viability effectively.
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PMC7022782
Subsequently, the pH of the mixture was adjusted to 7.4 with NaOH 0.2 M to ensure the end of the polymerization reaction.
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PMC9219615
Hence, to evaluate if Tpz-1 stimulates extrinsic apoptosis, we assessed the activation of caspase-8 via substrate assay kit following the manufacturer’s protocol (Abcam; Ab65614) to stain HL-60 cells after 4 h treatment with the 24 h CC50 or 2xCC50 of our compound.
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PMC11549612
For colony formation, transfected cells were seeded at 5×10 cells/well in 6-well plates.
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PMC11787381
Effects of bambuterol (green) after treatment with AβO (red) in a primary culture of hippocampal neurons.
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PMC9739791
However, the non-negligible dark toxicity led to the discontinuation of further development of this class of Pt(IV) complexes .
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PMC6889484
The results showed that, in the absence of Vif2 co-expression, the transduction efficiency with the A3G(DK) vector was nearly undetectable, while the transduction efficiency with the A33G(DK) and A3x3G(DK) viruses was increased to 28% and 49%, respectively (compare cells transduced with 20 ng p24 CA-containing virus).
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PMC9895440
Then cells were resuspended, the solution was transferred, the wells washed with FACS buffer and both fractions combined in one V-bottom well per condition.
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PMC9429973
The median HCT-CI score in the transplantable population was 2(range,0-12) and in the non-transplantable population was 1(range,0-5)(p=0.004); median CCI was respectively 1(range,1-9) and 0(range,0-3) (p<0.001).
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PMC11653533
Further, F. deltoidea leaves, stems and fruit extracts have shown moderate to weak antioxidant activity by drought stress, where the IC50 value of leaf extracts was 72.47 ± 0.050 μgmL, stem extracts were 157.71 ± 0.036 μgmL and fruit extracts was 401.20 ± 0.011 μgmL under 40 % water field capacity (Kusuma et al., 2019)...
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PMC11615218
Recently, increasing attention has been paid to TREG in CAR-T cell therapies, particularly their elevated levels in peripheral blood and infusion products, which are linked to inferior therapeutic responses [28, 49, 78–83].
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PMC11240571
In addition, data were analyzed with C6 software ver1.0.264.21 (BD Biosciences, Franklin Lakes, NJ, USA).
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PMC2196094
To study the specificity of these probes, the insert fragments were purified, labeled and used in a dot blot analysis.
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PMC10243817
The TGF-β/TGF-βR signaling pathway plays a vital role in the regulation of cell proliferation, differentiation, migration, ECM production, and cell metabolism (31, 33, 37).
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PMC11748363
Figure 2 demonstrates the influence of different substituents at positions R and R on antimycobacterial activity (Mtb H37Ra) with corresponding selectivity indices.
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PMC10165258
Etoposide is an anti-tumor drug that targets DNA topoisomerase II activities, thus leading to the production of DNA breaks and eliciting a response that affects several aspects of cell metabolisms; cisplatin is a platinum-based alkylating agent able to disrupt DNA repair mechanisms, causing DNA damage, and subsequently...
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PMC9080589
The absorbance was measured at 490 nm using an ELX-800 spectrometer reader (Bio-Tek Instruments, Winooski, USA).
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PMC8922418
Pietro et al. further demonstrated that disease in SIV-infected rhesus monkeys intravenously injected with AAV9-CRISPR/SaCas9 was alleviated by removing the integrated proviral DNA fragments in the genome of blood cells and tissues including the lymph nodes, spleen, bone marrow and brain (Mancuso et al., 2020).
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PMC11599565
ICC results from n = 6 experiments, FACS results from n = 3 experiments.
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PMC9672323
The effect of dexamethasone and piroxicam was measured on the TGF-β levels of T cells in PBMCs alone (a, d), U-87 MG cell line (b), A-172 cells (e), and in the co-culture with U-87 MG (c) and A-172 cells (f) (n = 4).
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PMC9429973
We analyzed cell proliferation and cell cycle changes using flow cytometry.
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PMC11731161
As mentioned above, although several previous studies have reported that SEL can induce XPO1 degradation, the underlying molecular mechanisms remain incompletely explored.
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PMC10998613
Addition of epinephrine reduced the mobility of CXCR4 and β2AR by an even larger amount (about 30%), indicating a relative increase in multimerization compared to CXCL12 addition.
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PMC7081114
However, no previous studies have focused on the function and mechanisms of KIF21B in cancer, particularly in HCC.
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PMC8358006
TBX20 expression was low in normal esophageal epithelial cells, but TBX20 was highly expressed in KYSE450 and KYSE510 cells and TCGA patients’ samples (Fig. 5b, Supplementary Fig. 11).
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PMC11770130
P < 0.05; ***P < 0.001; ns, not significant.
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PMC9429973
OMOP CDM maps commonly used coding systems and vocabularies, eg ICD-10, SNOMED-CT into standard concepts permitting raw data entering the registry to be standardised into a research ready format that is person-centric, disease agnostic and syntactically and semantically defined.
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PMC11684269
The functional integrity of T cells is tightly coupled to metabolic reprogramming.
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PMC11774112
The cells were then treated with Blank-PHRD, DTIC, miRNA 34a plasmid, PHRD/DTIC, PHRD/miRNA 34a and Co-PHRD for 72 h with 6 replicates per group.
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PMC9429973
Having MM or B-CLL was significantly associated with risk of humoral non-response.
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PMC8978939
Inhibiting the proteasome with MG132 (proteasome inhibitor) significantly increased both variants’ protein levels, achieving quantities comparable to WT pVHL levels after MG132 treatment for the case of P138R and slightly lower for L163R ( Figure 1D ).
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PMC11442172
A CoC is a micro-fluidic-based device that usually hosts multiple cell types in a more in vivo-like microenvironment where mechanical stimuli, flow, and rate of chemical release can be controlled (82, 83).
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PMC11271800
Low expression of secreted protein acidic and rich in cysteine 1 in gastrointestinal stromal tumor promotes the proliferation of blood vessels and tumor cells.
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PMC9429973
Disease progression was also significantly associated with patients who received Ruxolitinib compared to those who did not (p.value 0.000), and patients who needed cytoreduction therapy (p. 0.029) Regarding DIPPS-Plus, 39(63.9%) patients were encountered in low to Intermediate-1, while 22(36.1%) in Intermediate-2 to hi...
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PMC11194678
Though the K86,87E mutation on RBD2 or K266-268E mutation on RBD3 only partially weakened the level of STAU1 LLPS, combinational mutation of these two sites (referred to as 5KE hereafter) dramatically impaired droplet formation and reduced the condense phase fraction of STAU1 (Fig. 2 G and Fig. S1 L).
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PMC11756514
All cells were gated using forward and side scatter height, whereas single cells were gated using forward scatter area and forward scatter height; see the gating strategy in Supplementary Figure S3A .
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PMC11750161
The 7 potential phosphorylation sites (serine and threonine residues) are shown.
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PMC11610461
The specific information is summarized in Table 1.
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PMC10040136
The findings above suggest a novel mechanism of drug resistance involving the activation of paracrine pathways by interaction with MSC in the tumor microenvironment.
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PMC10747160
Moreover, N is not expressed on the viral surface, and E protein is only sparsely expressed on the surface of coronaviral particles, meaning that the addition of these structural proteins did not confer a significant number of glycan epitopes for Griffithsin to bind to .
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PMC10421378
Probiotic bacteria can promote the production of tight junction proteins, strengthen cell–cell junctions, and enhance the integrity of the gut barrier.
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PMC7823217
In another important study, 3D human skin equivalents (HSE) and melanoma skin equivalent (MSE) from human de‐epidermized dermis (DED), keratinocytes and fibroblasts were utilized for the study of vertical migration and invasion of myeloma cells.
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PMC11794847
Subsequent experiments confirmed that HVEM’s influence on T cell activation and metabolism is potentially mediated through its regulation of GPT2.
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PMC4112127
Panels of novel target genes which are regulated by DNA hypermethylation and have potential utility as biomarkers have been identified.
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PMC11733919
Afterward, the excess STV was removed using ultracentrifugal filters (Amicon, 100 kDa cutoff).
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PMC9424261
P < 0.05; **P < 0.01; ***P < 0.001 indicates statistical significance.
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PMC11066331
TUSC3 expression was downregulated by short hairpin RNA (shRNA) encoded in the lentiviral plasmid pLKO.1 and transduced into SKOV3 cells as described previously .
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PMC11297139
g Representative confocal images of 293T cells transfected with recombinant ARID1A and immunostained with anti-SMARCD and anti-SMARCC1 antibodies.
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PMC10772747
In the in vitro cytotoxicity assay, doxorubicin, EBE, and 1,4-naphthoquinone could exhibit varying activities from moderate to highly potent in T47D cells.
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PMC9429973
Conditioning regimen was myeloablative in 19 (38%) patients and reduced-intensity in 31 (62%).
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PMC6160470
The cell growth rate was evaluated after 72 hours of incubation, using MTT assay.
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PMC11279397
Its efficacy in combating viral infections extends beyond humans and encompasses other species as well.
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PMC11411004
The blots were developed using a Biotronik chemiluminescent HRP substrate.
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PMC9429973
Ruxolitinib (RUX), a JAK1/2 inhibitor, demonstrated superior efficacy over best available therapy (BAT) in the phase 3 REACH3 study (NCT03112603) in pts with SR/D cGVHD (Zeiser NEJM 2021).
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PMC10237474
After mixing with formic acid to a final concentration of 0.05%, 2 μg of protein was injected.
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PMC11267830
Peptides were separated on a reversed-phase column using a solvent gradient and then analyzed with a timsTOF™ Pro mass spectrometer in dia-PASEF mode.
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PMC11543853
This resulted in separate maps of positioned maps of ribosomes, microtubules, and rhinovirus 2 virions and empty particles.
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PMC5839394
At the end of the incubation period, medium was replaced with fresh medium and cells were incubated for 10 days.
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PMC10669128
However, these models present significant limitations, including high management costs, lengthy experimental processes, and the variable adherence of the animal model to human pathology.
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PMC5443223
In conclusion, the present study demonstrated that CEP164 deletion is involved in the IR-induced cellular response and enhances the radiosensitivity of rhabdomyosarcoma cells.
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PMC9412887
Nanomedicines in between this range are more easily captured in the spleen and liver than in the lungs .
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PMC11265931
Cancer has become an increasing problem worldwide, and numerous methods have been improved for the development of cancer therapy strategies (Nenclares and Harrington, 2020).
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