OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC7171147	Culturing COL11A1-low cells in the presence of COL11A1 extract or CAFs did not induce COL11A1 expression in the cancer cells (Fig. S1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC5839394	Figure 8 reports the histograms of protein level variations following the AgNPs-EPS treatment, compared with the untreated cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "8", "reports", "the", ...
PMC9960565	In the spectra, a shoulder was detected around 260 nm (Figure S47a), which was more evident for the higher generations of the PAMAM dendrimers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5916734	DNA was fixed by heating the membrane to 80°C for 2 h. Prehybridization and hybridization were carried out according to the procedure described in in a solution containing 7% sodium dodecyl sulfate, 0.5 M sodium phosphate, and 1% bovine serum albumin (BSA), pH 7.2, for 16 h at 65°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3734024	Given that FasL B cells showed higher surface expression of the IL-5 receptor, we hypothesized that IL-5 could be a survival and/or growth factor for these cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11345828	Suzuki coupling to indole 39 afforded compound 55.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Suzuki", "coupling", "to", "indole", "39", "afforded", "compound", "55", "." ] } ]
PMC10094712	The sequences of all primers used in the real-time PCRs are presented in Table 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sequences", "of", "all", "primers", "used", "in", ...
PMC11536589	These findings indicate that cancer cells with KRAS mutations and increased glutaminolysis may exhibit heightened susceptibility to ferroptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "indicate", "that", ...
PMC11266100	As predicted, by the YP data (Figure 4) nanosecond duration (300 ns) 5 kV/cm protocol is not optimal since does not trigger saturated permeabilization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Eight (72.7%) pts had ≥1 adverse event of special interest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eight", "(", "72.7", "%", ")", "pts", "had", "≥1", "adverse", "...
PMC11675244	In colorectal cancer, histone deacetylase inhibitors have been shown to suppress the clonogenicity and proliferation of cancer cells, both stem and non-stem, potentially through the activation of non-canonical Wnt pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10890055	During the degradation process of alloy, silver is released into the surrounding tissue, where it fulfils the antibacterial effect and subsequently is gradually eliminated from the human body by the liver and kidneys .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8143558	Unlike the viruses and bacteria, fungi are eukaryotic, a factor which makes it difficult to have them treated because antifungal agents may also be toxic to mammalian cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11773391	The relationship between MAPK/ERK pathway activity and MGMT expression in MM tissue has not been clearly defined in the literature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relationship", "betwe...
PMC11754784	For samples incubated with DNP1 and DNP3, CEM cells showed obvious FITC fluorescence while erythrocytes showed no fluorescence, indicating the improved CD47 binding specificity of Nb and accurate target CEM identification with reduced off-target effect in clinic human blood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11632064	A molecular weight marker was added to each gel for reference (Precision Plus Protein Dual Color, #1610374; Bio-Rad).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...
PMC9596868	Protein estimation was done using 1X Bradford reagent (Sigma-Aldrich, Cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "estimation", "was", "done", "using", "1X", "Bradford", "reagent", "("...
PMC11593031	Even though there are some differences in chromosome numbers (Figure 3) that reflect the well-known chromosome instability of cancer cells , the overall composite karyotypes and aCGH profiles are only slightly to moderately different when comparing Neuro-2a with Neuro-2a TR-alpha and Neuro-2a TR-beta (Figure 4, Figure ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11587541	Fig. 3Mechanism of Telomere shortening in motor neuron degeneration Mechanism of Telomere shortening in motor neuron degeneration The study on telomere attrition in spinal muscular atrophy (SMA) conducted in highly inbred regions of Jammu and Kashmir with a sample size of 40 cases and 58 controls may face several poten...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Currently, the Revised International Staging System (R-ISS) is widely used to assess patients’ prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", ",", "the", "Revised", "In...
PMC11568601	In order to explore the potential target of TGT in osteosarcoma, RNA-seq was applied to identify the DEGs in 143B cells that treated with TGT, and the potential target genes including DDIT3 and ERN1 were ultimately screened.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC8316344	D TRIB2 regulated TFRC expression in a PSMB5-independent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "TRIB2", "regulated", "TFRC", "expression", "in", "a", "PSMB5-independent", "manner", "." ] } ]
PMC11049294	Therefore, the early diagnosis and assessment for disease specific therapy eligibility to significantly halt the progression rate of Fabry disease is of critical importance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11786767	For chromosome segregation in anaphase, the total chromosome area and difference in area between the two sister chromosomes were analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "chromosome", ...
PMC11792766	A NOAEC of 0.5% v/v ethanol was determined via MTT for Caco‐2 cell line, whereas a value of 0.25% was derived from the LDH assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11541241	Considering that TOR is a lethal gene in eukaryotes from plants to pathogens, we should make sure that the dsRNAs specifically target the pathogen TOR genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	However, GRM can also cause musculoskeletal, endocrine, and gastrointestinal side effects and other toxicities, limiting their therapeutic effects (especially in long-term use).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	With a median follow-up of 5 months, the median OS of our cohort was 5 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "a", "median", "follow-up", "of", "5...
PMC11627060	The fluorescence intensity of FITC-BSA in each treatment group was quantitatively analyzed based on the number of NPs per vesicle or cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fluor...
PMC11803149	To address this, we first investigated the effect of Epas1 deficiency on CD8 T cell activation and cytotoxicity on target tumor cells in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC5173112	ChIP-qPCR results were calculated as % input.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ChIP-qPCR", "results", "were", "calculated", "as", "%", "input", "." ] } ]
PMC8348645	The absorbance was measured at 510 nm using a semi-autoanalyzer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "absorbance", "was", "measured", "at", "510", "nm", "using", "a", "semi-autoanalyzer", ...
PMC9100622	The data were deposited at the Gene Expression Omnibus (GEO; GSE62090).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "were", "deposited", "at", "the", "Gene", "Express...
PMC11394730	In the irinotecan-resistant (CPT-11-R) LoVo colon cancer cell line, thymoquinone was also discovered to stimulate autophagic cell death and trigger mitochondrial outer membrane permeability .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11758416	L cell culturing: L cells grow robustly but daily observation and timely passaging are essential to maintaining healthy, assay-ready cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "L", "cell", ...
PMC11319300	Notably, we did not see any interaction between the CTCF site upstream of MYEOV and TPCN2 CTCF sites (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably...
PMC11209164	Following the observed enhancement of oncolytic virus activity by TPF, we sought to examine the influence of TPF on other viral vectors, particularly non-replicating vectors used in gene therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Immune restoration was evaluated in 79 previously untreated pts with CLL enrolled in the CAPTIVATE Minimal Residual Disease (MRD) cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immune", "re...
PMC8973085	Anal.	[ { "tags": [ "O", "O" ], "tokens": [ "Anal", "." ] } ]
PMC11764090	Chloroplast acclimation may be the limiting factor for cold adaptation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chloroplast", "acclimation", "may", "be", "the", "limiting", "factor", "for", "cold", "adaptatio...
PMC9429973	Other coagulation factor activity levels were unchanged, and the presence of an FV inhibitor was revealed by the Bethesda inhibitor assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "coa...
PMC11155445	New acetylphenol-based acyl thioureas (142a–j) were synthesized by reacting different isothiocyanates with 1-(5-amino-2-hydroxyphenyl)ethan-1-one and investigated for urease inhibitory activity by Zahra et al. In vitro evaluation of the series revealed better inhibitory activity against urease enzyme than simple thiour...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7868205	In this study, an eco-friendly method using Rhizophora apiculata aqueous leaf extract as a reductant-rich hydrosol was followed to synthesize AgNPs and test its cytotoxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11591052	For this purpose, we used both the mouse C2C12 myoblasts and the mouse NIH/3T3 embryonic fibroblast cell line to see how 20E changed the expression of important enzymes for glycolysis and one-carbon metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Rituximab, Cyclophosphamide, Adriamycin, Vincristine, and prednisolone (R-CHOP) is the standard of care in newly diagnosed DLBCL and has been covered by National Health Insurance Service (NHIS) of Korea since October 2004.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11395280	The coverslips were blocked/permeabilized with blocking buffer (2% bovine serum albumin/PBS/0.1%Triton X-100) for 1 h and stained with anti-ZO-1-Alexa Fluor 647 conjugate (Cell Signaling Technologies #98225 (Danvers, MA, USA) for 2 h at a 1:100 dilution in blocking buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10932641	However, the prognosis is very poor, with a 5-year survival rate of only 10% to 20%, mainly attributed to the complexity and heterogeneity of the tumor microenvironment (TME).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3122064	Similar to its effects in patients, cisplatin proved to be an extremely cytotoxic drug, inducing massive apoptosis in human TC cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11300639	We showed that CDK4 enhances the interaction between TSC1 and RNF26 and that RNF26 activates the mTOR signaling pathway in ccRCC, contributes to ccRCC progression and angiogenesis, and promotes tumorigenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10170482	Labeled cells were imaged by confocal microscopy, and the digital images were quantified using the ImageJ software (NIH).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Labeled", "cells", ...
PMC10507284	Moreover, we further verified the expression of TROAP in STS and its relationship using in vitro experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "we", "further", "veri...
PMC10898159	TAT-N24 and the emerging PI3K or P55PIK inhibitors, such as Copanlisib, both inhibit NF -κB. BGJ398, PD173074 and nintedanib are FGFR inhibitor targeting FGFR1-4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median overall survival was 18 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "overall", "survival", "was", "18", "months", "." ] } ]
PMC11705862	Additionally, we found that prolonged exposure to high glucose or cytokines markedly reduces the expression of IRIS-1 and 2 in SH-SY5Y cells, suggesting a link between AD pathology and metabolic stress through modulation of these isoforms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11269792	Metabolic reprogramming is the earliest known cancer hallmark, which achieves tumor cell proliferation and survival by altering bioenergetic and biosynthetic pathways, and tumor cells exhibit a high rate of glycolysis, also known as the Warburg effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394227	Compared with CHO-PAb cells, co-overexpression of EQK and survivin decreased the VCDmax of CHO-PAb-QS cells by about 20%, but the cell viability period was prolonged by two days, indicating a longer stable period and longevity.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Each DNA sample was analyzed in duplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "DNA", "sample", "was", "analyzed", "in", "duplicate", "." ] } ]
PMC9429973	Results: The analysis included 110 patients, with median follow-up duration of 7.8 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "The", "analysis", "included", "110", "patie...
PMC11731614	However, the specific role of keratinocytes in PDN has not been widely investigated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "specific", "role", "of", "keratinocytes", ...
PMC11767817	Two families of CDK inhibitors, INK4 and CIP/KIP, are categorized by their CDK specificity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "families", "of", "CDK", "inhibitors", ",", ...
PMC9429973	All cHL cases were positive to PD-L1 against a non-neoplastic inflammatory background, while only two patients with DLBCL revealed positivity in a high percentage of neoplastic cells Using Hans’s algorithm, all DLBCL cases showed a non-GBC subtype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10170482	The intensity of fluorescence was measured using the Tecan microplate reader SpectraFluor Plus (Tecan, Männedorf, Switzerland).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "intensity", "of", ...
PMC11365983	Other phenotypes were less prevalent, as illustrated by a 15% prevalence of cerebellar hypoplasia, compared to ~ 100% in Joubert Syndrome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11092418	The cells (approximately 5 × 10) suspended in 2% FBS medium were added to 1.5 mL Eppendorf, centrifuged (254 × g for 3 min), washed once with cold PBS and incubated with or without 10 µg/mL of the primary antibody by rotation at 4 °C for 1 h. Following that, the cells were washed thrice with 1 mL of cold PBS by centrif...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144200	P < 0.05, ****P < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", ",", "", "", "", "", "P", "<", "0.0001", "." ] ...
PMC10055960	The distinctive absorption maxima of both precursor compounds (3 and 7) were noted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "distinctive", "absorption", "maxima", "of", "both", ...
PMC9250505	Each group in in vivo experiments contained at least six mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "group", "in", "in", "vivo", "experiments", "contained", "at", "least", "six",...
PMC11754094	Before electroporation, TrypLE (Gibco, 12604013) was used to generate a suspension of single cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Before", "electroporation", ",", "TrypLE", ...
PMC8524093	Infection of synovial macrophages is important to keep high viremia during the acute phase (Her et al., 2010; Ruiz Silva et al., 2016; Haist et al., 2017), and viral RNA was detected in these cells in both humans and non-human primates during the chronic phase of the disease, suggesting that persistent viral replicatio...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: Determine the effect of mitapivat on the number of transfusion episodes and RBC units transfused in pts with PK deficiency who were not regularly transfused, and randomized in the ACTIVATE trial.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11701801	.	[ { "tags": [ "O" ], "tokens": [ "." ] } ]
PMC11572213	Treatment with metformin increased 5-hmC levels and suppressed tumor growth by maintaining AMPK-mediated TET2 phosphorylation, indicating the tumor suppressor role of TET2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatme...
PMC10142392	The higher the molecular weight, the longer the natural decomposition of PCL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "higher", "the", "molecular", "weight", ",", "the", "longer", "...
PMC11024707	Twenty-one of the control group composed of the subjects applied for a routine check before attending a sports team, and 9 of them were being followed for a benign murmur.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489351	C, quantification of Notch reporter activity from images collected as in (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ",", "quantification", "of", "Notch", "reporter", "acti...
PMC8913139	We transferred protein samples into PVDF membranes and blocked it with 5% nonfat milk.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "transferred", "protein", "samples", "into", "PVDF", "...
PMC9429973	We generated a rank for Progression Free Survival (PFS), Overall Response Rate (ORR), Minimal Residual Disease (MRD), assessed by flow cytometry on peripheral blood, and tolerability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11402217	TUNEL staining fluorescence intensity average. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TUNEL", "staining", "fluorescence", "intensity", "average", ".", "(" ] } ]
PMC10761218	After incubation, the cells were examined in a half-confluent monolayer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "incubation", ",", "the", "cells", "were", "examined", "in", "a", "half-confl...
PMC9429973	Advances in data analytic methods allow for the combination of physician notes and structured data, potentially providing a more accurate and complete picture of disease manifestation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8316344	These data excluded that βTrCP/TFRC axis manipulates ferroptosis via GPX4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "excluded", "that", "βTrCP/TFRC", "axis", "manipulates", "ferroptosis", "via", "...
PMC11352746	One of the additional software modules available is called NeuroTrack.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "of", "the", "additional", "software", "modules", "available", "is", "called", "NeuroTrack...
PMC10812665	Replicates from the highest tested concentration of DES (42 µM) were excluded during the filtering step due to their low library size, potentially indicating cytotoxic effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723947	e Euler diagram showing the relationship between cluster 2 genes and those associated with peaks more open in Treg-exposed HP1γ KO Tconv than WT Tconv.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11683240	Histograms show fluorescence intensity of cells for one representative experiment for higher (C) and lower (D) concentrations (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11547917	Therefore, the IC50 (μg/mL) value, defined as the concentration of extract required to scavenge the formation of 50% of free radicals, was calculated using Excel software Version 130.0.2849.52 (Microsoft Corporation, Redmond, WA, USA) and expressed as mean ± standard deviation (SD) of three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604015	The common complications of various CAR-T cells include CRS, ICANS, GvHD, insertional mutagenesis, and second tumor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "common", "complicatio...
PMC11764090	Cold stress activates OST1, which regulates CBF stability through the OST1-BTF3 complex (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cold", "stress", "activates", "OST1", ",", ...
PMC9429973	No patient with NR taking effect after 12 months, new options should be considered with caution for them.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "patient", "with", "NR", ...
PMC9429973	Z. Iqbal, M. Absar, T. Akhtar, N. Alanazi, M. Shammas, S. Basit, A. Mahmood College of Applied Medical Sciences (CoAMS-A), King Saud Bin Abdulaziz University for Health Sciences / KAIMRC/ SSBMT, Al-Ahsa, Saudi Arabia; Hematology, Oncology and Pharmaco-genetic Engineering Sciences (HOPES) Group, Health Sciences Laborato...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10926885	ACC, BLCA, COAD, GBM, HNSC, LGG, PAAD, SARC and UCEC all showed substantial positive associations, while CHOL, PCPG and THCA showed significant negative correlations (Figure 6G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10582049	Our work has several limitations.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "work", "has", "several", "limitations", "." ] } ]
PMC11618052	LC-MS (m/z) for: C24H19N5OS (exact mass = 425.13): calculated [M + H]: 426.13; found [M + H]: 426.10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794588	Cestrum aurantiacum was least investigated, β-amyrin, cedryl acetate, lupeol, and 2-pentadecanone, 6,10,14-trimethyl were isolated from this species.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cestrum", "a...
PMC11064533	This was consistent with the idea that during bacterial attachment to the host cell, strain 4972 may utilize similar processes of adhesion on different cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC5600151	This system was also modified with LHRH peptide to promote tumor targeting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "system", "was", "also", "modified", "with", "LHRH", "peptide", "to", ...
PMC9429973	However, limited data exist on safety and efficacy of anti-MM regimens in patients (pts) with severe renal impairment and those requiring hemodialysis as pts are mostly excluded from clinical trials and specific trials in this indication are rare.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11286266	Equal sample volumes were analysed by SDS–PAGE and immunoblotting, as described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Equal", "sample", "volumes", "were", "analysed", "by", "SDS...
PMC9429973	In the ongoing first-in-human Phase I GO39775 study, intravenous (IV) administration of cevostamab monotherapy continues to show clinically meaningful activity and durable responses in patients with heavily pre-treated R/R MM (Trudel et al. ASH 2021), and uses Cycle (C) 1 step-up dosing for the mitigation of cytokine r...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7802142	Thus, NV can be an alternative strategy for clinical-scale production.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "NV", "can", "be", "an", "alternative", "strategy", "for", "clinical-scal...

PMC7171147

Culturing COL11A1-low cells in the presence of COL11A1 extract or CAFs did not induce COL11A1 expression in the cancer cells (Fig. S1C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC5839394

Figure 8 reports the histograms of protein level variations following the AgNPs-EPS treatment, compared with the untreated cells.

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PMC9960565

In the spectra, a shoulder was detected around 260 nm (Figure S47a), which was more evident for the higher generations of the PAMAM dendrimers.

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PMC5916734

DNA was fixed by heating the membrane to 80°C for 2 h. Prehybridization and hybridization were carried out according to the procedure described in in a solution containing 7% sodium dodecyl sulfate, 0.5 M sodium phosphate, and 1% bovine serum albumin (BSA), pH 7.2, for 16 h at 65°C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3734024

Given that FasL B cells showed higher surface expression of the IL-5 receptor, we hypothesized that IL-5 could be a survival and/or growth factor for these cells.

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PMC11345828

Suzuki coupling to indole 39 afforded compound 55.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Suzuki", "coupling", "to", "indole", "39", "afforded", "compound", "55", "." ] } ]

PMC10094712

The sequences of all primers used in the real-time PCRs are presented in Table 2.

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PMC11536589

These findings indicate that cancer cells with KRAS mutations and increased glutaminolysis may exhibit heightened susceptibility to ferroptosis.

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PMC11266100

As predicted, by the YP data (Figure 4) nanosecond duration (300 ns) 5 kV/cm protocol is not optimal since does not trigger saturated permeabilization.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Eight (72.7%) pts had ≥1 adverse event of special interest.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eight", "(", "72.7", "%", ")", "pts", "had", "≥1", "adverse", "...

PMC11675244

In colorectal cancer, histone deacetylase inhibitors have been shown to suppress the clonogenicity and proliferation of cancer cells, both stem and non-stem, potentially through the activation of non-canonical Wnt pathways .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10890055

During the degradation process of alloy, silver is released into the surrounding tissue, where it fulfils the antibacterial effect and subsequently is gradually eliminated from the human body by the liver and kidneys .

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PMC8143558

Unlike the viruses and bacteria, fungi are eukaryotic, a factor which makes it difficult to have them treated because antifungal agents may also be toxic to mammalian cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11773391

The relationship between MAPK/ERK pathway activity and MGMT expression in MM tissue has not been clearly defined in the literature.

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PMC11754784

For samples incubated with DNP1 and DNP3, CEM cells showed obvious FITC fluorescence while erythrocytes showed no fluorescence, indicating the improved CD47 binding specificity of Nb and accurate target CEM identification with reduced off-target effect in clinic human blood.

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PMC11632064

A molecular weight marker was added to each gel for reference (Precision Plus Protein Dual Color, #1610374; Bio-Rad).

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PMC9596868

Protein estimation was done using 1X Bradford reagent (Sigma-Aldrich, Cat.

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PMC11593031

Even though there are some differences in chromosome numbers (Figure 3) that reflect the well-known chromosome instability of cancer cells , the overall composite karyotypes and aCGH profiles are only slightly to moderately different when comparing Neuro-2a with Neuro-2a TR-alpha and Neuro-2a TR-beta (Figure 4, Figure ...

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PMC11587541

Fig. 3Mechanism of Telomere shortening in motor neuron degeneration Mechanism of Telomere shortening in motor neuron degeneration The study on telomere attrition in spinal muscular atrophy (SMA) conducted in highly inbred regions of Jammu and Kashmir with a sample size of 40 cases and 58 controls may face several poten...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Currently, the Revised International Staging System (R-ISS) is widely used to assess patients’ prognosis.

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PMC11568601

In order to explore the potential target of TGT in osteosarcoma, RNA-seq was applied to identify the DEGs in 143B cells that treated with TGT, and the potential target genes including DDIT3 and ERN1 were ultimately screened.

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PMC8316344

D TRIB2 regulated TFRC expression in a PSMB5-independent manner.

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PMC11049294

Therefore, the early diagnosis and assessment for disease specific therapy eligibility to significantly halt the progression rate of Fabry disease is of critical importance .

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PMC11786767

For chromosome segregation in anaphase, the total chromosome area and difference in area between the two sister chromosomes were analyzed.

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PMC11792766

A NOAEC of 0.5% v/v ethanol was determined via MTT for Caco‐2 cell line, whereas a value of 0.25% was derived from the LDH assay.

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PMC11541241

Considering that TOR is a lethal gene in eukaryotes from plants to pathogens, we should make sure that the dsRNAs specifically target the pathogen TOR genes.

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PMC10547921

However, GRM can also cause musculoskeletal, endocrine, and gastrointestinal side effects and other toxicities, limiting their therapeutic effects (especially in long-term use).

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PMC9429973

With a median follow-up of 5 months, the median OS of our cohort was 5 months.

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PMC11627060

The fluorescence intensity of FITC-BSA in each treatment group was quantitatively analyzed based on the number of NPs per vesicle or cell.

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PMC11803149

To address this, we first investigated the effect of Epas1 deficiency on CD8 T cell activation and cytotoxicity on target tumor cells in vitro.

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PMC5173112

ChIP-qPCR results were calculated as % input.

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PMC8348645

The absorbance was measured at 510 nm using a semi-autoanalyzer.

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PMC9100622

The data were deposited at the Gene Expression Omnibus (GEO; GSE62090).

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PMC11394730

In the irinotecan-resistant (CPT-11-R) LoVo colon cancer cell line, thymoquinone was also discovered to stimulate autophagic cell death and trigger mitochondrial outer membrane permeability .

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PMC11758416

L cell culturing: L cells grow robustly but daily observation and timely passaging are essential to maintaining healthy, assay-ready cells.

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PMC11319300

Notably, we did not see any interaction between the CTCF site upstream of MYEOV and TPCN2 CTCF sites (Figure 2A).

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PMC11209164

Following the observed enhancement of oncolytic virus activity by TPF, we sought to examine the influence of TPF on other viral vectors, particularly non-replicating vectors used in gene therapy.

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PMC9429973

Immune restoration was evaluated in 79 previously untreated pts with CLL enrolled in the CAPTIVATE Minimal Residual Disease (MRD) cohort.

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PMC8973085

Anal.

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PMC11764090

Chloroplast acclimation may be the limiting factor for cold adaptation .

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PMC9429973

Other coagulation factor activity levels were unchanged, and the presence of an FV inhibitor was revealed by the Bethesda inhibitor assay.

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PMC11155445

New acetylphenol-based acyl thioureas (142a–j) were synthesized by reacting different isothiocyanates with 1-(5-amino-2-hydroxyphenyl)ethan-1-one and investigated for urease inhibitory activity by Zahra et al. In vitro evaluation of the series revealed better inhibitory activity against urease enzyme than simple thiour...

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PMC7868205

In this study, an eco-friendly method using Rhizophora apiculata aqueous leaf extract as a reductant-rich hydrosol was followed to synthesize AgNPs and test its cytotoxicity.

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PMC11591052

For this purpose, we used both the mouse C2C12 myoblasts and the mouse NIH/3T3 embryonic fibroblast cell line to see how 20E changed the expression of important enzymes for glycolysis and one-carbon metabolism.

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PMC9429973

Rituximab, Cyclophosphamide, Adriamycin, Vincristine, and prednisolone (R-CHOP) is the standard of care in newly diagnosed DLBCL and has been covered by National Health Insurance Service (NHIS) of Korea since October 2004.

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PMC11395280

The coverslips were blocked/permeabilized with blocking buffer (2% bovine serum albumin/PBS/0.1%Triton X-100) for 1 h and stained with anti-ZO-1-Alexa Fluor 647 conjugate (Cell Signaling Technologies #98225 (Danvers, MA, USA) for 2 h at a 1:100 dilution in blocking buffer.

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PMC10932641

However, the prognosis is very poor, with a 5-year survival rate of only 10% to 20%, mainly attributed to the complexity and heterogeneity of the tumor microenvironment (TME).

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PMC3122064

Similar to its effects in patients, cisplatin proved to be an extremely cytotoxic drug, inducing massive apoptosis in human TC cell lines.

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PMC11300639

We showed that CDK4 enhances the interaction between TSC1 and RNF26 and that RNF26 activates the mTOR signaling pathway in ccRCC, contributes to ccRCC progression and angiogenesis, and promotes tumorigenesis.

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PMC10170482

Labeled cells were imaged by confocal microscopy, and the digital images were quantified using the ImageJ software (NIH).

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PMC10507284

Moreover, we further verified the expression of TROAP in STS and its relationship using in vitro experiments.

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PMC10898159

TAT-N24 and the emerging PI3K or P55PIK inhibitors, such as Copanlisib, both inhibit NF -κB. BGJ398, PD173074 and nintedanib are FGFR inhibitor targeting FGFR1-4.

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PMC9429973

Median overall survival was 18 months.

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PMC11705862

Additionally, we found that prolonged exposure to high glucose or cytokines markedly reduces the expression of IRIS-1 and 2 in SH-SY5Y cells, suggesting a link between AD pathology and metabolic stress through modulation of these isoforms.

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PMC11269792

Metabolic reprogramming is the earliest known cancer hallmark, which achieves tumor cell proliferation and survival by altering bioenergetic and biosynthetic pathways, and tumor cells exhibit a high rate of glycolysis, also known as the Warburg effect.

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PMC11394227

Compared with CHO-PAb cells, co-overexpression of EQK and survivin decreased the VCDmax of CHO-PAb-QS cells by about 20%, but the cell viability period was prolonged by two days, indicating a longer stable period and longevity.

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PMC9429973

Each DNA sample was analyzed in duplicate.

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PMC9429973

Results: The analysis included 110 patients, with median follow-up duration of 7.8 months.

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PMC11731614

However, the specific role of keratinocytes in PDN has not been widely investigated.

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PMC11767817

Two families of CDK inhibitors, INK4 and CIP/KIP, are categorized by their CDK specificity.

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PMC9429973

All cHL cases were positive to PD-L1 against a non-neoplastic inflammatory background, while only two patients with DLBCL revealed positivity in a high percentage of neoplastic cells Using Hans’s algorithm, all DLBCL cases showed a non-GBC subtype.

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PMC10170482

The intensity of fluorescence was measured using the Tecan microplate reader SpectraFluor Plus (Tecan, Männedorf, Switzerland).

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PMC11365983

Other phenotypes were less prevalent, as illustrated by a 15% prevalence of cerebellar hypoplasia, compared to ~ 100% in Joubert Syndrome.

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PMC11092418

The cells (approximately 5 × 10) suspended in 2% FBS medium were added to 1.5 mL Eppendorf, centrifuged (254 × g for 3 min), washed once with cold PBS and incubated with or without 10 µg/mL of the primary antibody by rotation at 4 °C for 1 h. Following that, the cells were washed thrice with 1 mL of cold PBS by centrif...

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PMC11144200

P < 0.05, ****P < 0.0001.

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PMC10055960

The distinctive absorption maxima of both precursor compounds (3 and 7) were noted.

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PMC9250505

Each group in in vivo experiments contained at least six mice.

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PMC11754094

Before electroporation, TrypLE (Gibco, 12604013) was used to generate a suspension of single cells.

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PMC8524093

Infection of synovial macrophages is important to keep high viremia during the acute phase (Her et al., 2010; Ruiz Silva et al., 2016; Haist et al., 2017), and viral RNA was detected in these cells in both humans and non-human primates during the chronic phase of the disease, suggesting that persistent viral replicatio...

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PMC9429973

Aims: Determine the effect of mitapivat on the number of transfusion episodes and RBC units transfused in pts with PK deficiency who were not regularly transfused, and randomized in the ACTIVATE trial.

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PMC11701801

.

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PMC11572213

Treatment with metformin increased 5-hmC levels and suppressed tumor growth by maintaining AMPK-mediated TET2 phosphorylation, indicating the tumor suppressor role of TET2.

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PMC10142392

The higher the molecular weight, the longer the natural decomposition of PCL.

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PMC11024707

Twenty-one of the control group composed of the subjects applied for a routine check before attending a sports team, and 9 of them were being followed for a benign murmur.

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PMC11489351

C, quantification of Notch reporter activity from images collected as in (B).

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PMC8913139

We transferred protein samples into PVDF membranes and blocked it with 5% nonfat milk.

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PMC9429973

We generated a rank for Progression Free Survival (PFS), Overall Response Rate (ORR), Minimal Residual Disease (MRD), assessed by flow cytometry on peripheral blood, and tolerability.

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PMC11402217

TUNEL staining fluorescence intensity average. (

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PMC10761218

After incubation, the cells were examined in a half-confluent monolayer.

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PMC9429973

Advances in data analytic methods allow for the combination of physician notes and structured data, potentially providing a more accurate and complete picture of disease manifestation.

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PMC8316344

These data excluded that βTrCP/TFRC axis manipulates ferroptosis via GPX4.

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PMC11352746

One of the additional software modules available is called NeuroTrack.

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PMC10812665

Replicates from the highest tested concentration of DES (42 µM) were excluded during the filtering step due to their low library size, potentially indicating cytotoxic effects.

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PMC11723947

e Euler diagram showing the relationship between cluster 2 genes and those associated with peaks more open in Treg-exposed HP1γ KO Tconv than WT Tconv.

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PMC11683240

Histograms show fluorescence intensity of cells for one representative experiment for higher (C) and lower (D) concentrations (n = 3).

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PMC11547917

Therefore, the IC50 (μg/mL) value, defined as the concentration of extract required to scavenge the formation of 50% of free radicals, was calculated using Excel software Version 130.0.2849.52 (Microsoft Corporation, Redmond, WA, USA) and expressed as mean ± standard deviation (SD) of three independent experiments.

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PMC11604015

The common complications of various CAR-T cells include CRS, ICANS, GvHD, insertional mutagenesis, and second tumor.

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PMC11764090

Cold stress activates OST1, which regulates CBF stability through the OST1-BTF3 complex (Figure 2).

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PMC9429973

No patient with NR taking effect after 12 months, new options should be considered with caution for them.

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PMC9429973

Z. Iqbal, M. Absar, T. Akhtar, N. Alanazi, M. Shammas, S. Basit, A. Mahmood College of Applied Medical Sciences (CoAMS-A), King Saud Bin Abdulaziz University for Health Sciences / KAIMRC/ SSBMT, Al-Ahsa, Saudi Arabia; Hematology, Oncology and Pharmaco-genetic Engineering Sciences (HOPES) Group, Health Sciences Laborato...

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PMC10926885

ACC, BLCA, COAD, GBM, HNSC, LGG, PAAD, SARC and UCEC all showed substantial positive associations, while CHOL, PCPG and THCA showed significant negative correlations (Figure 6G).

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PMC10582049

Our work has several limitations.

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PMC11618052

LC-MS (m/z) for: C24H19N5OS (exact mass = 425.13): calculated [M + H]: 426.13; found [M + H]: 426.10.

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PMC11794588

Cestrum aurantiacum was least investigated, β-amyrin, cedryl acetate, lupeol, and 2-pentadecanone, 6,10,14-trimethyl were isolated from this species.

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PMC11064533

This was consistent with the idea that during bacterial attachment to the host cell, strain 4972 may utilize similar processes of adhesion on different cells.

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PMC5600151

This system was also modified with LHRH peptide to promote tumor targeting.

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PMC9429973

However, limited data exist on safety and efficacy of anti-MM regimens in patients (pts) with severe renal impairment and those requiring hemodialysis as pts are mostly excluded from clinical trials and specific trials in this indication are rare.

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PMC11286266

Equal sample volumes were analysed by SDS–PAGE and immunoblotting, as described above.

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PMC9429973

In the ongoing first-in-human Phase I GO39775 study, intravenous (IV) administration of cevostamab monotherapy continues to show clinically meaningful activity and durable responses in patients with heavily pre-treated R/R MM (Trudel et al. ASH 2021), and uses Cycle (C) 1 step-up dosing for the mitigation of cytokine r...

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PMC7802142

Thus, NV can be an alternative strategy for clinical-scale production.

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