OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11530949	The findings highlight the potential of engineered NPs in cancer therapy and the importance of further research in this area (75-79).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11295144	Together, our results point to a key role of the γ2 subunit in facilitating the NL2-induced synapse formation and functional maturation in this co-culture model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10547921	Microtubules are an important part of the cytoskeleton in eukaryotic cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Microtubules", "are", "an", "important", "part", "of", "the", "cytoskeleton", "in", "...
PMC11687167	PCSK9 might be an attractive regulator of T-cell activation and expansion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCSK9", "might", "be", "an", "attractive", "regulator", "of", "T-cell", "activation", ...
PMC11155445	Compound (36) was found 100 times more potent than standard acetohydroxamic acid (IC50 = 15.92 ± 0.035 μM) with IC50 value of 0.21 ± 0.2 μM, The activity of the compound was attributed to presence of 1,2,4-triazole moiety (Scheme 10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9220170	To prevent contamination of genomic DNA, RNA samples were treated with DNase I at 37 °C for 1 h, after which the enzyme was inactivated by adding 50 mM EDTA to the mixture and heating to 60 °C for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11507371	For datasets containing more than 20 data points, the normality of the distribution was assessed by employing the Kolmogorov–Smirnov test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...
PMC11574271	The isotype-matched IgG was used as the control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "isotype-matched", "IgG", "was", "used", "as", "the", "control", "." ] } ]
PMC10507284	Herein, we display that TROAP exhibits an augmented trend in STS, and its elevation correlates with a poor prognosis of STS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Herein"...
PMC11525028	ASNS is the enzyme responsible for Asn biosynthesis. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ASNS", "is", "the", "enzyme", "responsible", "for", "Asn", "biosynthesis", ".", "(" ] } ]
PMC10040136	MSC cells from tumor tissue or human bone marrow sources were cultured in a complete DMEM medium as described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MSC", "cells", "from", ...
PMC11412752	For infection, bacteria were washed in PBS and subsequently resuspended in DMEM at a multiplicity of infection (MOI) of 10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...
PMC2196094	The mature protein of 226 aa has a molecular mass of 25,392 and has one putative N-glycosylation site (Asn-X-Ser/Thr) at position 58 of the mature protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10759659	The primers used for qPCR are listed in Supplementary file S3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primers", "used", "for", "qPCR", "are", "listed", "in", "Supplementary", "file...
PMC11279598	In the absence of options to current treatments such as antiestrogens (tamoxifen, fulvestrant) or aromatase inhibitors (anastrazole, letrozole, exemestane) alone or combined with CDK4/6 inhibitors, cytotoxic chemotherapy is often the only alternative for clinical management.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11698348	For immunohistochemical and immunocytochemistry analysis, 4% paraformaldehyde-fixed cells or cryostat sections (10μm) were blocked with 0.2% Triton-X-100/PBS, 5% fetal calf serum, 2% bovine serum albumin and 10% normal goat and/or donkey serum (Merck, UK) and incubated with primary antibodies against Elf5, Krt14, Krt15...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	Bioinks are the building blocks of bioprinted constructs, which are generally composed of a suitable hydrogel, multiple types of cells, nutrients, and growth factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012012	In another study, EAT-2 mRNA and protein were expressed in normal peripheral B cells as well as in CLL cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "another", "...
PMC4270159	Medium for cell lines: RPMI 1640 supplemented with 10% FBS, 50 U/ml penicillin, and 50 µg/ml streptomycin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Medium", "for", "...
PMC11703896	Hence the intercellular organelles and molecules were recycled to maintain the cellular homeostasis (Wang et al.,2022: Fan et al.,2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", "the...
PMC7868205	β is the line broadening in radians and θ is the Bragg’s angle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β", "is", "the", "line", "broadening", "in", "radians", "and", ...
PMC6835428	An interesting molecule to target in OC is thymidylate synthase (TS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "interesting", "molecule", "to", "target", "in", "OC", "is", "th...
PMC9429973	Results: At data cutoff (August 27, 2020), 67 patients were enrolled (low PC, n=21; higher PC, n=46; median age 68 years).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727000	The expression of the constructs was verified by immunoblotting (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "the", "constructs", "was", "verified", "by", ...
PMC10092581	Concerning GR activity, only complex [AgCl] was able to significantly reduce enzyme activity, concluding that all other derivatives were endowed with a preferential selectivity towards TrxR. The Trx system plays a fundamental role in cellular redox regulation, and inhibition of this redox regulatory system has been sho...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7136814	However, with solid tumors this strategy has shown limited results and it has therefore been proposed as a potential adjuvant to other therapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11742431	UMUC‐3 cells showed a similar trend, but none of the overall fluorescence intensities were as bright as 5637 cells (Figure 3B).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], ...
PMC8633974	Cell genomic DNA was isolated, and nested PCR was performed with HIV specific primers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "genomic", "DNA", "was", "isolated", ",", "and", ...
PMC10243817	Aberrant expression of TGF-β/TGF-βR family members has been reported in human airway diseases including CRS (25, 30, 38); however, our current understanding of the regulation of TGF-β/TGF-βR family members is very limited, particularly for TGF-βR3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7504302	Malignant pleural mesothelioma is a heterogeneous cancer with complex underlying molecular alterations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Malignant", "pleural", "mesothelioma", "is", "a", "heterogeneous", "cancer", "with", ...
PMC9856122	Researchers are also exploring natural products to find the potentiality against newly emerged SARS-CoV-2 viral infection .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Researchers", "are", "also", "exploring", "natural", "...
PMC11759543	Cytotoxicity of vorinostat for 24, 48 and 72 h treatment. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytotoxicity", "of", "vorinostat", "for", "24", ",", "48", "and", "72", "h...
PMC9024365	Graph depicts the mean cluster size of GluA1 alone (n = 10), GluA1 + SD4 (n = 12), GluA2 alone (n = 16), GluA2 + SD4 (n = 10), GluK2 alone (n = 13), or GluK2 + SD4 (n = 11) puncta. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11411131	After exposure to 6 µM MeHg for 24 h, the signals from both antibodies decreased. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "exposure", "to", "6", "µM", "MeHg"...
PMC10998613	Specifically, asymmetrical single-stranded oligos were designed to introduce an in-frame premature stop codon and phosphorothioate modifications were included near the 5′ and 3′ ends of the oligos.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The primary study endpoint was safety and tolerability; secondary endpoints included efficacy outcomes (ORR, DOR, PFS, and OS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9577200	This activity was enhanced >5 times when combined with curcumin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "activity", "was", "enhanced", ">", "5", "times", "when", "combined", "with", ...
PMC11185260	Zeta potential (surface charge) of nanocomplexes. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zeta", "potential", "(", "surface", "charge", ")", "of", "nanocomplexes", ".", "(" ] } ]
PMC11045125	As the transcription factor Myb is expressed at very high levels in the ΔEBNA2 + Myc lymphomas (Fig 5B), and Myb not only serves as a master regulator of GC B cell identity and survival [51,60–62] but is also expressed at very high levels in immature B cells [63–65], we next examined whether Myc activation of Myb is re...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11419566	These studies were published earlier and only performed cell experiments to test these conclusions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "studies", "were", "published", "earlier", "and", "only", ...
PMC10135767	Calcium signaling triggered by integrin LFA-1 binding with ICAM-1 occurs due to the influx of calcium in neutrophils and HL-60 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Calcium", "sig...
PMC11144200	Software called GraphPad Prism 9.0.0 has been employed to statistically analyze the data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Software", "called", "GraphPad", "Prism", "9.0.0", "has", "been", "employed...
PMC9878562	Confocal images of sections of a tumor generated by injecting a 1:1 mixture of VAL-wt and VAL-ko (CFP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Confocal", "images", "of", ...
PMC10362265	Two disulfide bridges (E35-R105, K34-D122) were spotted for both chains.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "disulfide", "bridges", "(", "E35-R105", ",", "K34-D122", ")", ...
PMC11186948	The same trend was observed for #249 compared to HD lysates for abundance of lysine 27 of histone 3 acetylated (H3ac) normalized on histone 3 (H3) (Fig. 5B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7081114	Thus, there is an urgent need to identify novel diagnostic and prognostic biomarkers for HCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "there", "is", "an", "urgent", "need...
PMC11695623	YU showed that knockdown of CENPA reduced the proliferation of lung adenocarcinoma cells and regulated the characteristics of tumor stem cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "YU", "showed", "t...
PMC11461833	Next, the sequence containing intron 11(I11) to E12 was amplified from human genomic DNA with the forward primer 5’-CTGCCAGCGGCTCAGGAGCCCAGGTGGGtGGACCCATCTC-3’ and R1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC3931643	From a panel of diffuse large B-cell lymphoma cell lines, we found that the VAL cell line is particularly resistant to apoptosis in the presence of active-site mTOR inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11686380	Finally, we did not evaluate the stability of human GAP43 mutant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "we", "did", "not", "evaluate", "the", "stability", "of", "...
PMC11290772	Subsequent to transfection, the NK cells were cultured for an additional 24 h and sorted using flow cytometry with the Anti-CAR antibody (0799-R271-F, Sinobiological, Beijing, CN).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11764090	On the other hand, overexpression of MYB96 in plants can result in strong cold tolerance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "overexpression", ...
PMC11774747	In this study, Caruana et al., explored another way to enhance expansion and proliferation of CAR-VST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "Caruana", ...
PMC11269933	In Vivo PK activity assay (B–I) (n = 3; B), PEP content (n = 3; C) and PA content (n = 3; D) of C. gigas and C. angulata during heat stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3730428	Moreover, FLIP is the product of an NFκB target gene (CFLAR) and therefore is upregulated following TNFR1 ligation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...
PMC11653533	An evergreen tree with a crown that is both elongated and broad, Ficus auriculata can grow to a height of between 4 and 10 m. They have greyish-brown bark with an unpleasant texture, and their central stem branchlets are leafless, which can be 1–1.5 cm thick; they also have a rosy brown colour (El-Fishawy et al., 2012)...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: This post hoc analysis used a planned interim readout (June 15, 2020) of CANDOR (NCT03158688).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":...
PMC11705901	First, we will canvass possible reasons for the null results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "First", ",", "we", "will", "canvass", "possible", "reasons", "for", "the", "null", ...
PMC6379402	Annotations that are statistically significantly enriched in the overlapping network regions are combined into “functional domains”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Annotations", "that", "are", "statistically"...
PMC11687167	Vaccines targeting PCSK9 were also investigated in tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vaccines", "targeting", "PCSK9", "were", "also", "investigated", "in", "tumor", "cells", "." ] } ]
PMC10507284	The STS individuals were further divided into low and high‐risk groups based on the median risk score, which was convenient for subsequent analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11787651	Metaboanalyst 6.0 was used for this plot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Metaboanalyst", "6.0", "was", "used", "for", "this", "plot", "." ] } ]
PMC11791264	F, LC3B protein levels were determined by Western blot in HEK293T cells stably expressing pCDH or pCDH-SETD7 in the presence of 10 μM MG132 or 50 μM chloroquine (CQ) for 10 h. G and H, HEK293T (G) or SKOV3 cells (H) were co-transfected with FLAG-tagged ubiquitin (Ub), HA-tagged SETD7, or empty vector pCMV3-N-HA (HA), t...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	CD8 spike specific tetramer binding was also observed in seronegative patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD8", "spike", "specific", "tetramer", "binding", "was", "also", "observed", "in", "s...
PMC11522251	Fig. 5HOXB8 overexpression reduces cetuximab sensitivity in SW48 cell lines A–C Following HOXB8 overexpression in SW48 cells, mRNA and protein levels were assessed using qRT-PCR and protein blotting techniques. **	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Summary/Conclusion: Spatial analysis demonstrated that patients with AA and PGF exhibit similar patterns of protein expression likely resulting in a BM immune microenvironment of decreased immunoregulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	At database cutoff (Nov 1, 2021), 20 patients had discontinued treatment due to adverse events (n=7); disease progression or clinical progression (n=11); or withdrawal/physician decision (n=2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This is in contrast with 100% patients with an underlying malignancy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "in", "contrast", "with", "100", "%", "patients", "with", "an...
PMC11534035	On the other hand, treatment with GPER1 antagonist, G36, revealed a notable disparity in cell behavior between the two cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11756514	The illustrations are not to scale.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "illustrations", "are", "not", "to", "scale", "." ] } ]
PMC8358176	No changes were observed in the expression of CD40LG in MWCNT- (1.62 ± 0.27) and SWCNT-treated Jurkat cells (1.75 ± 0.08) in comparison to the control cells (1.37 ± 0.31; p = 0.241).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC5330095	Research grade CBD (Item No.: C-045) [Figure 1] was purchased from Cerilliant Reference Standards (www.cerilliant.com).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Research", "...
PMC10291556	Phagocytosis was classified by the occurrence of double-positive macrophages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phagocytosis", "was", "classified", "by", "the", "occurrence", "of", "double-positive", "macrophages", "." ...
PMC6461034	Pre‐wet the HLB sorbent with 6 ml acetonitrile and apply vacuum to achieve a flow rate of 1 drop per second (1–1.5 ml/min).Wash three times with 6 ml 0.1% TFA.Load the acidified and cleared digest in several portions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607321	Purple represents measured screens, while orange represents gaps, i.e., missing screens, which were synthetically generated with MOSA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Purple", "represents", ...
PMC10745221	Because they are more sensitive to PRMT inhibition, MTAP-deleted cancers can be selectively targeted .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Because", "they", "are", "more", "sensitive", "to", "PRMT",...
PMC10547921	BRD4 inhibitors 124 are conjugated to interchain Cys residues of mAb targeting HER2 using maleimide-based conjugation, resulting in ADC conjugates that reduce BRD4 levels in BT-474 (HER2-positive) cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC11457557	However, new data predict the likelihood of T2DM, and when paired with appropriate phenotypes, these are expected to shed light on the pathogenesis of T2DM subgroups in the near future making it an important part as both diagnostic and therapeutic tools.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11389534	UFMylation has emerged as a key regulator in tumour progression through modulating PD‐1/PD‐L1 signalling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "UFMylation", "has", "emerged", "as", "a", "key", "regulator...
PMC11499381	As such, the CLR/RAMP1 complex may occur more frequently than the CTR/RAMP1 complex, leading to a higher fluorescence output with CLR-based receptors; however, at this point, this conclusion is purely speculative.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10006224	Reads from calibrated ChIP-seq are plotted in a 5-kb window centered in the summits of cohesin positions with and without CTCF (24,912 and 14,607 positions, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Among them, 15 cases (34.1%) had simple abnormal blood image as chief complaint, and 17 cases (38.6%) had non-specific rash on physical examination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9398137	The efficacy and safety profile of several specific MCL1 inhibitors will be determined in near future in the currently running clinical trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effic...
PMC3164356	On the other hand, classes for which few genes were identified (that is, <1% of the instances in human and mouse and significantly depleted, P < 0.01) included behavior, embryo development and anatomical structure morphogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748335	This elucidates the increased enrichment of long LOCKs in common PMDs within tumor cell lines (Fig. 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "elucidates", "the", "incr...
PMC10482220	Cos cells were transiently transfected with GFP-BC, GFP-ABC, or GFP-BCD, treated with arsenite before fixation, and double stained with fluorescent oligo-dT probe (red).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10165258	The calibration curves for the drug concentration and its fluorescence signal when used in our microfluidic platforms are shown in Figure S3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "calib...
PMC11746948	h Immunoblots of GPX4 and ZDHHC20 in A375 cells infected with lentiviruses encoding empty vector or ZDHHC20.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "h", "Immunoblots", "of", "GPX4", "and", ...
PMC9429973	The effects on cell viability were assessed by XTT assay at 72 hours of treatment, while OPN expression and production were evaluated by qRT-PCR and ELISA, respectively, at 72 and 96 hours of treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	We measure the quality of factorization by relative square error (RSE) between the decomposed adjacency matrices and the corresponding decompositions:9[12pt] $$} = _i \, A_i - GS_iG^}}\, _}^2}}_i A_}}^2}}.$$=∑i∥Ai-GSiGT∥F2∑iAiF2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Inotuzumab ozogamicin (InO), a new antibody–drug conjugate, has shown significant activity in adult patients with r/r B-ALL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inotuzu...
PMC10198699	In 1951, she was diagnosed with cancer and was undergoing treatment at Johns Hopkins Hospital in the United States.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "1951", ",", "she...
PMC11699465	Transmembrane proteins participate in various vital biological processes such as signal transduction, transportation, membrane trafficking, and immune responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transmembrane", "protei...
PMC9429973	T. Vassilakopoulos, A. Piperidou, Z. Mellios, E. Verigou, C. Kalpadakis, E. Katodritou, S. Papageorgiou, C. Chatzidimitriou, C. Giatra, T. Leonidopoulou, V. Xanthopoulos, S. Karakatsanis, G. Gainaru, E. Vrakidou, A. Koumarianou, E. Hatzimichael, E. Verrou, M. Tsirogianni, I. Drandakis, M. A. Lefaki, A. Liaskas, A. Kops...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: Patients with trisomy 19 are very heterogeneous in particular with respect to cytogenetic and molecular abnormalities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Patients", "with"...
PMC11758416	Note: Counts should be adjusted based on desired ratio of Effector:Target cells as described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Note", ":", "Counts", "should", "be", ...
PMC6268318	Moreover, the MeOH extract also significantly lowered the serum GPT level in mice with D-GalN/lipopolysaccharide (LPS)-induced liver injury (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreove...
PMC9429973	Aims: To investigate the clinico-pathological and molecular features of a well characterized bicentric series of 54 patients (pts) with HCV positive DLBCL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11320834	The 20 ng of DNA was used as input in the CleanPlex BRCA1 & BRCA2 Panel v3 (Paragon Genomics Inc., CA, US).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11694066	Scatter plot shows the percentage of PD-L1–positive cells within the DAPI-negative population, normalized to the siCNTRL DMSO condition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scatter", "plot", "shows", "the",...

PMC11530949

The findings highlight the potential of engineered NPs in cancer therapy and the importance of further research in this area (75-79).

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PMC11295144

Together, our results point to a key role of the γ2 subunit in facilitating the NL2-induced synapse formation and functional maturation in this co-culture model.

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PMC10547921

Microtubules are an important part of the cytoskeleton in eukaryotic cells.

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PMC11687167

PCSK9 might be an attractive regulator of T-cell activation and expansion.

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PMC11155445

Compound (36) was found 100 times more potent than standard acetohydroxamic acid (IC50 = 15.92 ± 0.035 μM) with IC50 value of 0.21 ± 0.2 μM, The activity of the compound was attributed to presence of 1,2,4-triazole moiety (Scheme 10).

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PMC9220170

To prevent contamination of genomic DNA, RNA samples were treated with DNase I at 37 °C for 1 h, after which the enzyme was inactivated by adding 50 mM EDTA to the mixture and heating to 60 °C for 10 min.

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PMC11507371

For datasets containing more than 20 data points, the normality of the distribution was assessed by employing the Kolmogorov–Smirnov test.

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PMC11574271

The isotype-matched IgG was used as the control.

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PMC10507284

Herein, we display that TROAP exhibits an augmented trend in STS, and its elevation correlates with a poor prognosis of STS.

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PMC11525028

ASNS is the enzyme responsible for Asn biosynthesis. (

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PMC10040136

MSC cells from tumor tissue or human bone marrow sources were cultured in a complete DMEM medium as described above.

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PMC11412752

For infection, bacteria were washed in PBS and subsequently resuspended in DMEM at a multiplicity of infection (MOI) of 10.

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PMC2196094

The mature protein of 226 aa has a molecular mass of 25,392 and has one putative N-glycosylation site (Asn-X-Ser/Thr) at position 58 of the mature protein.

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PMC10759659

The primers used for qPCR are listed in Supplementary file S3.

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PMC11279598

In the absence of options to current treatments such as antiestrogens (tamoxifen, fulvestrant) or aromatase inhibitors (anastrazole, letrozole, exemestane) alone or combined with CDK4/6 inhibitors, cytotoxic chemotherapy is often the only alternative for clinical management.

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PMC11698348

For immunohistochemical and immunocytochemistry analysis, 4% paraformaldehyde-fixed cells or cryostat sections (10μm) were blocked with 0.2% Triton-X-100/PBS, 5% fetal calf serum, 2% bovine serum albumin and 10% normal goat and/or donkey serum (Merck, UK) and incubated with primary antibodies against Elf5, Krt14, Krt15...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7823217

Bioinks are the building blocks of bioprinted constructs, which are generally composed of a suitable hydrogel, multiple types of cells, nutrients, and growth factors.

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PMC11012012

In another study, EAT-2 mRNA and protein were expressed in normal peripheral B cells as well as in CLL cells .

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PMC4270159

Medium for cell lines: RPMI 1640 supplemented with 10% FBS, 50 U/ml penicillin, and 50 µg/ml streptomycin.

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PMC11703896

Hence the intercellular organelles and molecules were recycled to maintain the cellular homeostasis (Wang et al.,2022: Fan et al.,2013).

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PMC7868205

β is the line broadening in radians and θ is the Bragg’s angle.

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PMC6835428

An interesting molecule to target in OC is thymidylate synthase (TS).

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PMC9429973

Results: At data cutoff (August 27, 2020), 67 patients were enrolled (low PC, n=21; higher PC, n=46; median age 68 years).

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PMC11727000

The expression of the constructs was verified by immunoblotting (Figure 1A).

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PMC10092581

Concerning GR activity, only complex [AgCl] was able to significantly reduce enzyme activity, concluding that all other derivatives were endowed with a preferential selectivity towards TrxR. The Trx system plays a fundamental role in cellular redox regulation, and inhibition of this redox regulatory system has been sho...

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PMC7136814

However, with solid tumors this strategy has shown limited results and it has therefore been proposed as a potential adjuvant to other therapies.

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PMC11742431

UMUC‐3 cells showed a similar trend, but none of the overall fluorescence intensities were as bright as 5637 cells (Figure 3B).

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PMC8633974

Cell genomic DNA was isolated, and nested PCR was performed with HIV specific primers.

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PMC10243817

Aberrant expression of TGF-β/TGF-βR family members has been reported in human airway diseases including CRS (25, 30, 38); however, our current understanding of the regulation of TGF-β/TGF-βR family members is very limited, particularly for TGF-βR3.

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PMC7504302

Malignant pleural mesothelioma is a heterogeneous cancer with complex underlying molecular alterations.

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PMC9856122

Researchers are also exploring natural products to find the potentiality against newly emerged SARS-CoV-2 viral infection .

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PMC11759543

Cytotoxicity of vorinostat for 24, 48 and 72 h treatment. (

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PMC9024365

Graph depicts the mean cluster size of GluA1 alone (n = 10), GluA1 + SD4 (n = 12), GluA2 alone (n = 16), GluA2 + SD4 (n = 10), GluK2 alone (n = 13), or GluK2 + SD4 (n = 11) puncta. (

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PMC11411131

After exposure to 6 µM MeHg for 24 h, the signals from both antibodies decreased. (

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PMC10998613

Specifically, asymmetrical single-stranded oligos were designed to introduce an in-frame premature stop codon and phosphorothioate modifications were included near the 5′ and 3′ ends of the oligos.

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PMC9429973

The primary study endpoint was safety and tolerability; secondary endpoints included efficacy outcomes (ORR, DOR, PFS, and OS).

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PMC9577200

This activity was enhanced >5 times when combined with curcumin.

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PMC11185260

Zeta potential (surface charge) of nanocomplexes. (

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PMC11045125

As the transcription factor Myb is expressed at very high levels in the ΔEBNA2 + Myc lymphomas (Fig 5B), and Myb not only serves as a master regulator of GC B cell identity and survival [51,60–62] but is also expressed at very high levels in immature B cells [63–65], we next examined whether Myc activation of Myb is re...

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PMC11419566

These studies were published earlier and only performed cell experiments to test these conclusions.

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PMC10135767

Calcium signaling triggered by integrin LFA-1 binding with ICAM-1 occurs due to the influx of calcium in neutrophils and HL-60 cells .

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PMC11144200

Software called GraphPad Prism 9.0.0 has been employed to statistically analyze the data.

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PMC9878562

Confocal images of sections of a tumor generated by injecting a 1:1 mixture of VAL-wt and VAL-ko (CFP).

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PMC10362265

Two disulfide bridges (E35-R105, K34-D122) were spotted for both chains.

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PMC11186948

The same trend was observed for #249 compared to HD lysates for abundance of lysine 27 of histone 3 acetylated (H3ac) normalized on histone 3 (H3) (Fig. 5B).

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PMC7081114

Thus, there is an urgent need to identify novel diagnostic and prognostic biomarkers for HCC.

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PMC11695623

YU showed that knockdown of CENPA reduced the proliferation of lung adenocarcinoma cells and regulated the characteristics of tumor stem cells.

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PMC11461833

Next, the sequence containing intron 11(I11) to E12 was amplified from human genomic DNA with the forward primer 5’-CTGCCAGCGGCTCAGGAGCCCAGGTGGGtGGACCCATCTC-3’ and R1.

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PMC3931643

From a panel of diffuse large B-cell lymphoma cell lines, we found that the VAL cell line is particularly resistant to apoptosis in the presence of active-site mTOR inhibitors.

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PMC11686380

Finally, we did not evaluate the stability of human GAP43 mutant.

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PMC11290772

Subsequent to transfection, the NK cells were cultured for an additional 24 h and sorted using flow cytometry with the Anti-CAR antibody (0799-R271-F, Sinobiological, Beijing, CN).

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PMC11764090

On the other hand, overexpression of MYB96 in plants can result in strong cold tolerance .

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PMC11774747

In this study, Caruana et al., explored another way to enhance expansion and proliferation of CAR-VST.

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PMC11269933

In Vivo PK activity assay (B–I) (n = 3; B), PEP content (n = 3; C) and PA content (n = 3; D) of C. gigas and C. angulata during heat stress.

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PMC3730428

Moreover, FLIP is the product of an NFκB target gene (CFLAR) and therefore is upregulated following TNFR1 ligation.

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PMC11653533

An evergreen tree with a crown that is both elongated and broad, Ficus auriculata can grow to a height of between 4 and 10 m. They have greyish-brown bark with an unpleasant texture, and their central stem branchlets are leafless, which can be 1–1.5 cm thick; they also have a rosy brown colour (El-Fishawy et al., 2012)...

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PMC9429973

Methods: This post hoc analysis used a planned interim readout (June 15, 2020) of CANDOR (NCT03158688).

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PMC11705901

First, we will canvass possible reasons for the null results.

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PMC6379402

Annotations that are statistically significantly enriched in the overlapping network regions are combined into “functional domains”.

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PMC11687167

Vaccines targeting PCSK9 were also investigated in tumor cells.

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PMC10507284

The STS individuals were further divided into low and high‐risk groups based on the median risk score, which was convenient for subsequent analysis.

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PMC11787651

Metaboanalyst 6.0 was used for this plot.

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PMC11791264

F, LC3B protein levels were determined by Western blot in HEK293T cells stably expressing pCDH or pCDH-SETD7 in the presence of 10 μM MG132 or 50 μM chloroquine (CQ) for 10 h. G and H, HEK293T (G) or SKOV3 cells (H) were co-transfected with FLAG-tagged ubiquitin (Ub), HA-tagged SETD7, or empty vector pCMV3-N-HA (HA), t...

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PMC9429973

CD8 spike specific tetramer binding was also observed in seronegative patients.

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PMC11522251

Fig. 5HOXB8 overexpression reduces cetuximab sensitivity in SW48 cell lines A–C Following HOXB8 overexpression in SW48 cells, mRNA and protein levels were assessed using qRT-PCR and protein blotting techniques. **

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PMC9429973

Summary/Conclusion: Spatial analysis demonstrated that patients with AA and PGF exhibit similar patterns of protein expression likely resulting in a BM immune microenvironment of decreased immunoregulation.

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PMC9429973

At database cutoff (Nov 1, 2021), 20 patients had discontinued treatment due to adverse events (n=7); disease progression or clinical progression (n=11); or withdrawal/physician decision (n=2).

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PMC9429973

This is in contrast with 100% patients with an underlying malignancy.

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PMC11534035

On the other hand, treatment with GPER1 antagonist, G36, revealed a notable disparity in cell behavior between the two cell lines.

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PMC11756514

The illustrations are not to scale.

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PMC8358176

No changes were observed in the expression of CD40LG in MWCNT- (1.62 ± 0.27) and SWCNT-treated Jurkat cells (1.75 ± 0.08) in comparison to the control cells (1.37 ± 0.31; p = 0.241).

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PMC5330095

Research grade CBD (Item No.: C-045) [Figure 1] was purchased from Cerilliant Reference Standards (www.cerilliant.com).

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PMC10291556

Phagocytosis was classified by the occurrence of double-positive macrophages.

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PMC6461034

Pre‐wet the HLB sorbent with 6 ml acetonitrile and apply vacuum to achieve a flow rate of 1 drop per second (1–1.5 ml/min).Wash three times with 6 ml 0.1% TFA.Load the acidified and cleared digest in several portions.

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PMC11607321

Purple represents measured screens, while orange represents gaps, i.e., missing screens, which were synthetically generated with MOSA.

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PMC10745221

Because they are more sensitive to PRMT inhibition, MTAP-deleted cancers can be selectively targeted .

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PMC10547921

BRD4 inhibitors 124 are conjugated to interchain Cys residues of mAb targeting HER2 using maleimide-based conjugation, resulting in ADC conjugates that reduce BRD4 levels in BT-474 (HER2-positive) cell lines.

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PMC11457557

However, new data predict the likelihood of T2DM, and when paired with appropriate phenotypes, these are expected to shed light on the pathogenesis of T2DM subgroups in the near future making it an important part as both diagnostic and therapeutic tools.

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PMC11389534

UFMylation has emerged as a key regulator in tumour progression through modulating PD‐1/PD‐L1 signalling pathway.

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PMC11499381

As such, the CLR/RAMP1 complex may occur more frequently than the CTR/RAMP1 complex, leading to a higher fluorescence output with CLR-based receptors; however, at this point, this conclusion is purely speculative.

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PMC10006224

Reads from calibrated ChIP-seq are plotted in a 5-kb window centered in the summits of cohesin positions with and without CTCF (24,912 and 14,607 positions, respectively).

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PMC9429973

Among them, 15 cases (34.1%) had simple abnormal blood image as chief complaint, and 17 cases (38.6%) had non-specific rash on physical examination.

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PMC9398137

The efficacy and safety profile of several specific MCL1 inhibitors will be determined in near future in the currently running clinical trials.

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PMC3164356

On the other hand, classes for which few genes were identified (that is, <1% of the instances in human and mouse and significantly depleted, P < 0.01) included behavior, embryo development and anatomical structure morphogenesis.

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PMC11748335

This elucidates the increased enrichment of long LOCKs in common PMDs within tumor cell lines (Fig. 3A).

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PMC10482220

Cos cells were transiently transfected with GFP-BC, GFP-ABC, or GFP-BCD, treated with arsenite before fixation, and double stained with fluorescent oligo-dT probe (red).

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PMC10165258

The calibration curves for the drug concentration and its fluorescence signal when used in our microfluidic platforms are shown in Figure S3.

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PMC11746948

h Immunoblots of GPX4 and ZDHHC20 in A375 cells infected with lentiviruses encoding empty vector or ZDHHC20.

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PMC9429973

The effects on cell viability were assessed by XTT assay at 72 hours of treatment, while OPN expression and production were evaluated by qRT-PCR and ELISA, respectively, at 72 and 96 hours of treatment.

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PMC6379402

We measure the quality of factorization by relative square error (RSE) between the decomposed adjacency matrices and the corresponding decompositions:9[12pt] $$} = _i \, A_i - GS_iG^}}\, _}^2}}_i A_}}^2}}.$$=∑i∥Ai-GSiGT∥F2∑iAiF2.

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PMC9429973

Inotuzumab ozogamicin (InO), a new antibody–drug conjugate, has shown significant activity in adult patients with r/r B-ALL.

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PMC10198699

In 1951, she was diagnosed with cancer and was undergoing treatment at Johns Hopkins Hospital in the United States.

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PMC11699465

Transmembrane proteins participate in various vital biological processes such as signal transduction, transportation, membrane trafficking, and immune responses.

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PMC9429973

T. Vassilakopoulos, A. Piperidou, Z. Mellios, E. Verigou, C. Kalpadakis, E. Katodritou, S. Papageorgiou, C. Chatzidimitriou, C. Giatra, T. Leonidopoulou, V. Xanthopoulos, S. Karakatsanis, G. Gainaru, E. Vrakidou, A. Koumarianou, E. Hatzimichael, E. Verrou, M. Tsirogianni, I. Drandakis, M. A. Lefaki, A. Liaskas, A. Kops...

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PMC9429973

Summary/Conclusion: Patients with trisomy 19 are very heterogeneous in particular with respect to cytogenetic and molecular abnormalities.

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PMC11758416

Note: Counts should be adjusted based on desired ratio of Effector:Target cells as described above.

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PMC6268318

Moreover, the MeOH extract also significantly lowered the serum GPT level in mice with D-GalN/lipopolysaccharide (LPS)-induced liver injury (Table 1).

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PMC9429973

Aims: To investigate the clinico-pathological and molecular features of a well characterized bicentric series of 54 patients (pts) with HCV positive DLBCL.

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PMC11320834

The 20 ng of DNA was used as input in the CleanPlex BRCA1 & BRCA2 Panel v3 (Paragon Genomics Inc., CA, US).

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PMC11694066

Scatter plot shows the percentage of PD-L1–positive cells within the DAPI-negative population, normalized to the siCNTRL DMSO condition.

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