Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC10317042
P < 0.05; **, P < 0.01 (Student t test).
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PMC11476106
As the A673 cell line (established in 1973) has undergone numerous 2D culture passages, the cells have experienced several transformations, new mutations, and loss of their original flexibility.
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PMC3888431
The Isogroup object is used to group all splice variants of a gene or all transcripts of a cluster.
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PMC11627060
The shape and surface morphology of NPs, as observed through SEM, significantly influence their interaction with cells.
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PMC11738017
Figure created with BioRender.com. (
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PMC11301931
FSP1’s role in ChRCC is unexplored.
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PMC10571053
Asterisks denote significant differences from the DMSO control, where ***P < 0.001 or ****P < 0.0001.
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PMC10729469
Study cessation was mandated after active immunization due to the development of meningoencephalitis in a few of the treated patients .
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PMC10890055
Extracts of the aforementioned materials were more toxic for L929 than for hFOB 1.19 (Figure 5).
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PMC9429973
ctDNA was genotyped and quantified by phased variant-enhanced-LyV4.0 ctDNA CAPP-seq assay.
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PMC8978939
Values are expressed as ± SD of three independent experiments performed in triplicate.
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PMC11470999
We then established A375 cell lines with stable knockdown of each of these E3 ligases (Figure 6A) and treated them with varying concentrations of PF.
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PMC11173119
Despite the existing data on MEFV mutations, the exact mechanism of their effect on the development of the pathological processes leading to the spontaneous and recurrent autoinflammatory attacks observed in FMF, remains unclear.
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PMC11696659
In a large prospective study of heavy smokers who developed lung cancer, short telomere length determined before diagnosis was associated with increased risk of death in patients with small cell lung cancer (SCLC) .
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PMC11487720
B Endogenous TRAF2 (stained in green) in Wwox knockout MEF cells did not relocate to the nuclei (stained with DAPI) in response to UV/cold shock (~ 200 cells counted).
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PMC8481254
Next, Bel-7404 (5 × 10 cells) expressing GFP and subjected to different treatments were subcutaneously injected into 8-week-old athymic nude mice (SLAC) with or without STZ treatment.
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PMC11803918
ROS generation ability and cytolytic function of photosensitive hybrid γδ-T exosomes. (
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PMC9429973
The median age is 57.4years(47-72).
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PMC11805741
The name Paracoccus was developed from the words “Para” (Greek for alongside or like) and “coccus” (Latin for grain or fruit).
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PMC9622879
In the no-CEMS community, certain homes still require energy from the EP because they cannot buy it from other homes where the surplus energy has to be sold back to the EP.
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PMC9429973
Patients aged ≥18 years with a confirmed diagnosis of intermediate or high-risk primary MF (PMF), post-polycythemia vera MF (PPV-MF) or post-essential thrombocythemia MF (PET-MF) who had received or were currently receiving ruxolitinib treatment per clinical judgment according to China approved label were included.
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PMC6102174
Interferons and nucleoside analogs are the most common drugs for CHB in clinic.
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PMC9429973
No dose-limiting toxicities were observed at 200 mg and 300 mg BID.
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PMC11656380
Relative gene expression was then compared between the groups.
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PMC10387886
TGFβ1 (Transforming growth factor β1) has a key role in the induction of EMT .
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PMC11297139
Right: quantification of the spheroid formation assay.
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PMC11699178
900 μL of the ECMatrix™ solution was mixed with 100 μL of 10 × ECMatrix™ Dilution Buffer in a sterile microcentrifuge tube.
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PMC9429973
Aims: We aim at exploring the putative associations between germline and somatic molecular signatures found in a cohort of consecutive patients diagnosed with HMMS at Hospital La Fe, in Valencia (Spain).
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PMC11348300
injection.
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PMC10197932
The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Ethics Committee of NETWORK TELETHON DI BIOBANCHE GENETICHE (code GTB.12001 (GGDB).
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PMC11604015
Autologous T cells have no GvHD or rejection, but tumor contamination is a major problem for this kind of CAR-T cells.
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PMC9429973
Patients could be newly diagnosed during the patient identification window or could be diagnosed prior to their index date, allowing for the inclusion of patients with differing disease duration and organ involvement.
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PMC11756514
The cells were collected by centrifugation at 200 x g and washed twice before incubation with 0.5 µg/mL streptavidin-BV241 (cat.
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PMC10778532
Expression of Vimentin and Twist were not significantly changed by the sunitinib treatment for the three cells lines (Figure 4F, Figures S3 and S9).
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PMC11723947
We generated mice homozygous for a LoxP-flanked Hp1a allele and crossed them with CMV-cre transgenic mice.
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PMC11509224
Compound (−)-agelasine D (42) inhibited the growth of planktonic forms of the biofilm-forming bacterium Staphylococcus epidermidis, with an MIC < 0.0877 µM. The compound spongionellol A (213) showed cytotoxicity against seven cancer cell lines, with IC50 values ranging from 0.94 to 2.64 µM. Kalihinols O–T (11–16) showed antifouling activity against Balanus amphitrite larvae, with EC50 values ranging from 0.53 to 1.48 µM. The diversity in chemical structure and biological activity exhibited by these sponge-derived diterpenoids demonstrates their great potential in the development of marine drugs.
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PMC9739791
Moreover, Coumaplatin 14 was found to trigger an immune response as three major ICD biomarkers (calreticulin exposure, release of high-mobility group box 1 protein, and ATP secretion) were activated in A549cisR cells upon exposure to Coumaplatin 14; activation of those biomarkers was not observed after incubation with oxaliplatin.
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PMC11489351
Replicate cells were also treated for 24 h with a gamma-secretase inhibitor (DAPT).
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PMC11680562
1Schematic presentation of preparation of green synthesized CuO NPs Schematic presentation of preparation of green synthesized CuO NPs Initially, the pectin (400 mg) and xanthan gum (Table 1) was slowly introduced into warm water (~ 50 °C) to dissolve completely, and the polymer mixture was brought back to room temperature.
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PMC11704834
Hence, it was examined whether reversing induced EMT in A549GR cells by ectopic expression of the TLE1 target E-cadherin gene restores their sensitivity to gefitinib.
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PMC7039683
Interestingly, SNP2 also had the strongest negative deltaSVM of all the OFC-risk-associated SNPs when the classifier was trained on mPEAEs or on hOEAEs, although in neither case were the deltaSVM values significant outliers in comparison to those of the 1000 randomly-selected SNPs (SNP2, Bonferroni corrected p values of 0.126 and 0.238, respectively) (Supplementary file 3b-e).
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PMC11656380
Effect of macropinocytosis inhibitor EIPA on the uptake of Tamra-Tat-Ram13 in CCRF-CEM cells. (
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PMC11461833
In addition, the percentage of SA--Gal-positive cells was lower when STXBP5 was knocked down (Fig. 4C).
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PMC11454015
Understanding the unique interactions between E-cadherin loss and ER in ILC could lead to novel therapeutic approaches for the prevention and treatment of ILC.
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PMC9895440
d Degranulation measured by CD107a surface exposure during re-stimulation of all cells after 13 days of culture.
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PMC10840195
Predicted EMT (A) and Wnt (B) signalling pathway interacting proteins in the STRING database.
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PMC8992508
The inhibitory activity against P-gp and MRP1 was studied by using the calcein AM assay on P-gp overexpressing A2780 adr and MRP1 overexpressing H69AR cells, respectively.
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PMC11544122
Similarly, the negative BRET observed when GRK2 was expressed (Fig. 6c), we hypothesize, similar to the 4A variant (Fig. 5c), is due to enhanced β-arrestin recruitment at high concentrations of CXCL12, although we have yet to confirm this.
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PMC4270159
Calculate cell viability by dividing the fluorescence from the drug-treated cells by the fluorescence from the control (vehicle) treated cells.
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PMC11678841
Originally recognized for its antimicrobial properties , other health-promoting activities have been documented for the different preparations obtained from this plant, including free radical scavenging , antioxidant , and anti-inflammatory effects.
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PMC7294030
Aurisin A-induced cell-cycle arrest in the G0/G1 phase The effect of aurisin A on cell-cycle distribution of the A549 cell line was determined by flow cytometry analysis.
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PMC11747467
Tumors with different treatments are shown. (
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PMC11267830
In summary, the findings show that indisulam exhibits profound antitumor activity in T-ALL in vitro models.
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PMC11566417
The supernatants, enriched for epithelial cells in suspension were transferred to new wells of a 6-well plate for another 1 h (h).
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PMC8984067
On the other hand, no C-O stretching vibration peaks (strong and wide peak between 1000 and 1200 cm) were observed, indicating that hydroxyethyl cellulose is only used as a reaction medium during the synthesis process, whose role was to probably form a uniform dense gel inhibiting the growth of UCNPs particles.
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PMC11257203
Moreover, Maity et al. observed that the indomethacin treatment in an indomethacin-induced gastric damage model leads to the development of mitochondrial oxi dative stress as indicated by increased depletion of mitochondrial GSH content and augmentation of mitochondrial lipid peroxidation, indicated by increased MDA (24).
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PMC11585587
Mitochondria, as the central organelles of cells, coordinates the physiological processes such as apoptosis.
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PMC9429973
We could successfully implement an app (myTcell) guiding health workers in a disease- and product-specific step by step process through the clinical workflow of CAR and BiTE therapy.
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PMC11746948
n = 6.
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PMC6442998
Recently, Nazir et al. unraveled the correlation between high PDE3A expression level and sensibility to PDE3 inhibitors in various solid cancers.
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PMC5415764
The reversal indexes ranged from 3–8 when TET was used at different ratios with PTX.
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PMC11727062
Furthermore, it down-regulates the expression of matrix metalloproteinases MMP-2 and MMP-9, thereby attenuating the migration of drug-resistant cells both in vitro and in vivo.
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PMC11218145
Six-week-old female Non-Obese Diabetic Severe Combined Immunodeficient (NOD-SCID) mice were purchased from ENVIGO (San Pietro al Natisone, Udine, Italy).
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PMC11783017
D–F) Representative flow cytometry plots and positive percentage of M1-type macrophages (CD86) and M2-type macrophages (CD206). (
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PMC6133382
The full list and procedure are described in S1 and S2 Tables.
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PMC7887261
Basic characteristics of LC cases and controls in the discovery and validations sets.
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PMC11775197
It also exerted anti-angiogenic effects in vitro by inhibiting the VEGF/VEGFR2 signaling pathway.
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PMC11473750
For endogenous MYCN immunoprecipitation assays, cells were lysed in cold NP40 buffer (Sigma) supplemented with protease inhibitor (Sigma).
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PMC9429973
Monotherapy with cobimetinib was used as a second line therapy in all cases.
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PMC9219615
Despite its reputation as a proto-oncogene, elevated Hck activity may act as a tumor suppressor in some leukemias, including AML , which is relevant to our use of HL-60 cells herein.
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PMC11082662
The results from scratch experiments showed that decreased SMPDL3B expression significantly inhibited the migration of ovarian cancer cells, with SMPDL3B#2 demonstrating a notable inhibitory effect on the proliferation of SK-OV-3 and HEY (Figure 5A,5B; P<0.01).
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PMC8358006
a Kaplan–Meier estimates of overall survival of patients with low- or high-expression level of TBX20 in TCGA ESCC patients (left) and with mutated or not mutated TBX20 in TCGA Pan-Cancer (right).
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PMC11352746
Primary neuronal cells are obtained directly from an animal or human brain and plated for culture .
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PMC9874064
BRCA1 protein expression in BEL-7404DPP cells treated with different drugs for 48 ​h by WB.
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PMC11389534
In the progression of protein translocation, ribosome stalling triggers RPL26 UFMylation.
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PMC11683240
To explore whether the sequence of PT and α1AT application to cells influences the inhibition, we analyzed cell intoxication by PT after introducing PT and α1AT in varying orders (Fig. 8).
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PMC11092382
Furthermore, Wang discovered that Qingluoyin exerts anti-inflammatory effects in rats with rheumatoid arthritis by upregulating PPAR-γ expression, thereby modulating monocyte/macrophage polarization and adipocyte differentiation (Wang et al., 2021c).
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PMC6133382
Inactivation or deficiency of the MGAT1 limits N-linked glycosylation to early oligomannose glycans (Man5-9) and enhances the binding of bN-mAbs to glycan-dependent epitopes, as compared to earlier gp120 vaccines produced in normal CHO cells.
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PMC11607638
Low CCK at 1 nM had no effect, but at 10 nM and 100 nM CCK elicited clear calcium increases in the SKR‐CHO‐K1 cells (Figure 6B–D).
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PMC9454178
J Immunoblot analyses showed that OSR1 overexpression promoted c-KIT expression in GIST-T1 and GIST-882 cells.
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PMC6182045
A total of 1.5 × 10 transfected cells was serially diluted and grown on semi-solid media containing G418 and anti-gp120 polyclonal antibodies labeled with Alexa Fluor 488 (see Materials and Methods).
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PMC9429973
Pts receiving CB-010 do not require leukapheresis or bridging therapy.
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PMC7812570
Monoplex PCRs were set up in duplicate in 20-µl reaction volumes using Applied Biosystems TagMan Fast Advanced Master Mix in a 96-well plate on the Bio-Rad CFX96 real-time PCR platform.
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PMC11064533
It is important to note that the parameters of the MIC assay and adhesion assay with antibiotic stress are widely different and cannot be compared directly, but it is necessary to highlight the peculiar behavior of the clumpy adhesion phenotype, which allows the bacteria to survive an extremely high concentration of one antibiotic, i.e., ampicillin (16 mg/mL), while leaving them more susceptible to another, i.e., gentamicin (2 µg/mL) at a lower concentration.
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PMC11269933
Based on single site mutation, we constructed Flag-CgPk and its Ser11 mutants (Flag-CgPk [mimicking dephosphorylation] and Flag-CgPk [mimicking phosphorylation]).
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PMC9812014
These down-regulatory actions of Tetrandine on the anti-herpes immune response imply that this alkaloid can be used to control an early exuberant inflammatory response without compromising virus clearance from the eye.
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PMC9429973
Caspase 8 plays an important role in apoptosis and several studies have been performed to clarify the relationship between polymorphisms in Casp8 gene and different types of cancer.
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PMC11699178
6Molecular mechanisms of GEM treatment in breast cancer Molecular mechanisms of GEM treatment in breast cancer In this study, ovarian cancer scRNA-seq data were obtained from the TCGA public database for cell-specific gene analysis and GO/KEGG enrichment analysis.
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PMC11772449
The Bliss independent model assumes that the onset process of different drugs is independent and random, which is suitable for two drugs with different targets.
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PMC11025866
There are no published studies linking CHAC1 with the Epstein-Barr virus (EBV).
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PMC10452486
Inference: Dimerization of B2m-free HCs may involve cysteine–cysteine linkages between two heavy chains.
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PMC11711063
In Bex + Carv‐treated mice, immunostaining showed reduced Ki67 and abundant cleaved Caspase‐3 levels in the proliferative and the apoptotic zones (Figure 5E,F).
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PMC11641532
Therefore, increasing the clinical sample size and validating HSD3B7 as a therapeutic target in patient-derived xenografts and clinical specimens are essential next steps.
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PMC8164677
1mM solution of cisplatin was made (0.00150 g/5 mL) by dissolving powder in DMF followed by mQ water (1:4).
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PMC11307990
786-0 cells were cultured with DNA nanotapes, SUN, and DNA nanotape-SUN for 24 h, respectively.
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PMC11774251
Tan-I is a promising therapeutic candidate for psoriasis, effectively mitigating inflammation, normalizing keratinocyte differentiation, and inhibiting abnormal keratinocyte apoptosis.
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PMC11740508
Significance determined by two-way ANOVA with Tukey’s adjustment for multiple testing. ****,
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PMC10571053
Additionally, both P-gp and ABCG2 localize to the gastrointestinal tract as well as to other barrier sites, such as the blood-brain barrier (BBB).
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PMC7351993
Label-free sorting of fully differentiated adipocyte-like cells with unique spatial features (e.g., spatial distribution or localization of cytoplasmic lipid droplets, cell area, total lipid amount) is important since the differentiation and lipogenesis of adipocytes are a highly heterogeneous process and overcomes difficulties of fluorescence-based technologies in analyzing cytoplasmic lipid droplets in a quantitative manner.
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PMC10994876
Consequently, YAP can be restrained by spatial segregation from its nuclear target transcription factors, such as TEAD (left).
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